TY  - JOUR
AU  - Micić, Sava
AU  - Lalić, Nataša
AU  - Đorđević, Dejan
AU  - Bojanić, Nebojša
AU  - Bogavac-Stanojević, Nataša
AU  - Busetto, Gian Maria
AU  - Virmani, Ashraf
AU  - Agarwal, Ashok
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3347
AB  - Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p  lt  0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p  lt  0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and alpha-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p  lt  0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility.
PB  - Wiley, Hoboken
T2  - Andrologia
T1  - Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia
VL  - 51
IS  - 6
DO  - 10.1111/and.13267
ER  - 

@article{
author = "Micić, Sava and Lalić, Nataša and Đorđević, Dejan and Bojanić, Nebojša and Bogavac-Stanojević, Nataša and Busetto, Gian Maria and Virmani, Ashraf and Agarwal, Ashok",
year = "2019",
abstract = "Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p  lt  0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p  lt  0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and alpha-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p  lt  0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility.",
publisher = "Wiley, Hoboken",
journal = "Andrologia",
title = "Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia",
volume = "51",
number = "6",
doi = "10.1111/and.13267"
}

Micić, S., Lalić, N., Đorđević, D., Bojanić, N., Bogavac-Stanojević, N., Busetto, G. M., Virmani, A.,& Agarwal, A.. (2019). Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. in Andrologia
Wiley, Hoboken., 51(6).
https://doi.org/10.1111/and.13267

Micić S, Lalić N, Đorđević D, Bojanić N, Bogavac-Stanojević N, Busetto GM, Virmani A, Agarwal A. Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. in Andrologia. 2019;51(6).
doi:10.1111/and.13267 .

Micić, Sava, Lalić, Nataša, Đorđević, Dejan, Bojanić, Nebojša, Bogavac-Stanojević, Nataša, Busetto, Gian Maria, Virmani, Ashraf, Agarwal, Ashok, "Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia" in Andrologia, 51, no. 6 (2019),
https://doi.org/10.1111/and.13267 . .