TY  - JOUR
AU  - Velikinac, I
AU  - Čudina, Olivera
AU  - Janković, I
AU  - Agbaba, Danica
AU  - Vladimirov, S
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/554
AB  - A capillary zone electrophoresis (CZE) and a high-performance liquid chromatography (HPLC) method have been developed for identification and determination of ketoconazole, an imidazole antifungal, in pharmaceutical preparations. The suitabilities of both methods for quantitative determination of ketoconazole were approved through validation specification such as linearity, precision, accuracy, limit of detection and quantification. The proposed methods were used for determination of ketoconazole in commercial pharmaceutical dosage forms (tablets and creams). Under described conditions, CZE method is more selective, while the HPLC method is more sensitive. Both methods are rapid (t R (CZE)=5.14 min and t R (HPLC)=2.66 min), which is important for routine application. However, the HPLC method provides a repeatability of the quantitative analysis of ketoconazole in drug formulations below 1.5% relative standard deviation (R.S.D), while the repeatability of the CZE method is in the order of 2-3% R.S.D.
PB  - Elsevier Masson SAS
T2  - Farmaco
T1  - Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations
VL  - 59
IS  - 5
SP  - 419
EP  - 424
DO  - 10.1016/j.farmac.2003.11.019
ER  - 

@article{
author = "Velikinac, I and Čudina, Olivera and Janković, I and Agbaba, Danica and Vladimirov, S",
year = "2004",
abstract = "A capillary zone electrophoresis (CZE) and a high-performance liquid chromatography (HPLC) method have been developed for identification and determination of ketoconazole, an imidazole antifungal, in pharmaceutical preparations. The suitabilities of both methods for quantitative determination of ketoconazole were approved through validation specification such as linearity, precision, accuracy, limit of detection and quantification. The proposed methods were used for determination of ketoconazole in commercial pharmaceutical dosage forms (tablets and creams). Under described conditions, CZE method is more selective, while the HPLC method is more sensitive. Both methods are rapid (t R (CZE)=5.14 min and t R (HPLC)=2.66 min), which is important for routine application. However, the HPLC method provides a repeatability of the quantitative analysis of ketoconazole in drug formulations below 1.5% relative standard deviation (R.S.D), while the repeatability of the CZE method is in the order of 2-3% R.S.D.",
publisher = "Elsevier Masson SAS",
journal = "Farmaco",
title = "Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations",
volume = "59",
number = "5",
pages = "419-424",
doi = "10.1016/j.farmac.2003.11.019"
}

Velikinac, I., Čudina, O., Janković, I., Agbaba, D.,& Vladimirov, S.. (2004). Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations. in Farmaco
Elsevier Masson SAS., 59(5), 419-424.
https://doi.org/10.1016/j.farmac.2003.11.019

Velikinac I, Čudina O, Janković I, Agbaba D, Vladimirov S. Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations. in Farmaco. 2004;59(5):419-424.
doi:10.1016/j.farmac.2003.11.019 .

Velikinac, I, Čudina, Olivera, Janković, I, Agbaba, Danica, Vladimirov, S, "Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations" in Farmaco, 59, no. 5 (2004):419-424,
https://doi.org/10.1016/j.farmac.2003.11.019 . .