TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Marković, Bojan
AU  - Lusiana
AU  - Hoffmann, Christine
AU  - Mueller-Goymann, Christel
AU  - Milić, Jela
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2194
AB  - Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance
VL  - 40
IS  - 7
SP  - 960
EP  - 971
DO  - 10.3109/03639045.2013.794827
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Marković, Bojan and Lusiana and Hoffmann, Christine and Mueller-Goymann, Christel and Milić, Jela and Daniels, Rolf and Savić, Snežana",
year = "2014",
abstract = "Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ones. In that context, alkyl polyglucosides (APG) emerge as prominent natural-origin emulsifiers with numerous favorable features (biodegradability, dermatological acceptability, desirable sensory properties). Objective: To evaluate APG-stabilized bases (alone and upon addition of isopropyl alcohol) and their impact on skin performance. A simultaneous in vitro/in vivo skin absorption study was conducted to evaluate whether the tape stripping technique could be recommended as an in vivo tool for skin penetration assessment during formulation optimization process. Materials and methods: After a comprehensive physicochemical characterization, biopharmaceutical properties of APG-bases versus reference ones were assessed through a combined in vitro (release/permeation) and in vivo approach. Results and discussion: Physicochemical characterization revealed substantial difference in structural ordering due to the formation of various mesomorphic phases. The enhancer-loaded APG base resulted in significantly higher drug levels at all depths into the stratum corneum, indicating that the selected enhancer along with specific colloidal structure has increased the extent of drug delivery. Conclusion: Results recommend the investigated emulsifier for stabilization of topical drug delivery systems, not only for their ability to sustain the addition of isopropyl alcohol which proved to be a valuable enhancer, but also satisfactory skin absorption and tolerability when compared to samples stabilized by conventional emulsifier. Tape stripping proved to be a useful and yet inexpensive tool for in vivo trials, able to discriminate subtle differences in dermal availability.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance",
volume = "40",
number = "7",
pages = "960-971",
doi = "10.3109/03639045.2013.794827"
}

Pantelić, I., Lukić, M., Marković, B., Lusiana, Hoffmann, C., Mueller-Goymann, C., Milić, J., Daniels, R.,& Savić, S.. (2014). Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 40(7), 960-971.
https://doi.org/10.3109/03639045.2013.794827

Pantelić I, Lukić M, Marković B, Lusiana, Hoffmann C, Mueller-Goymann C, Milić J, Daniels R, Savić S. Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance. in Drug Development and Industrial Pharmacy. 2014;40(7):960-971.
doi:10.3109/03639045.2013.794827 .

Pantelić, Ivana, Lukić, Milica, Marković, Bojan, Lusiana, Hoffmann, Christine, Mueller-Goymann, Christel, Milić, Jela, Daniels, Rolf, Savić, Snežana, "Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance" in Drug Development and Industrial Pharmacy, 40, no. 7 (2014):960-971,
https://doi.org/10.3109/03639045.2013.794827 . .

TY  - JOUR
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Daniels, Rolf
AU  - Mueller-Goymann, Christel
AU  - Savić, Miroslav
AU  - Savić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1956
AB  - Mesomorphic behavior of the novel long-chain alkyl polyglucoside emulsifier comprising arachidyl alcohol (C-20), behenyl alcohol (C-22), and arachidyl glucoside was investigated in order to determine the prevalent stabilization mechanism and moisturizing capacity of emulsion systems based on it. For this to be accomplished thermoanalytical methods (differential scanning calorimetry and thermogravimetric analysis) coupled with microscopy, rheological, X-ray diffraction methods and a short-term in vivo study of skin hydration level were performed. Obtained results have proved that C-20/C-22 alkyl polyglucoside mixed emulsifier is able to provide the synergism between the two main types of lamellar phases, the liquid-crystalline (L alpha), and the gel crystalline (L beta) one, building the emulsion systems of different stability and performance. Formation of lamellar structures influenced for more than one half of water within the system to be entrapped. Conducted investigation of hydration potential in real-time conditions provided valuable information on the investigated emulsion vehicles' moisturizing potential as well as their contribution to the skin barrier improvement. Therefore, it could be expected that emulsions based on this alkyl polyglucoside emulsifier could influence the delivery of active ingredients of both the lipophilic and hydrophilic type. The employment of thermoanalytical methods in our work suggests the possibility for thermal methods to be used more frequently in the characterization of both the novel raw materials and the belonging emulsion systems.
PB  - Springer, Dordrecht
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development
VL  - 111
IS  - 3
SP  - 2045
EP  - 2057
DO  - 10.1007/s10973-012-2263-0
ER  - 

@article{
author = "Lukić, Milica and Pantelić, Ivana and Daniels, Rolf and Mueller-Goymann, Christel and Savić, Miroslav and Savić, Snežana",
year = "2013",
abstract = "Mesomorphic behavior of the novel long-chain alkyl polyglucoside emulsifier comprising arachidyl alcohol (C-20), behenyl alcohol (C-22), and arachidyl glucoside was investigated in order to determine the prevalent stabilization mechanism and moisturizing capacity of emulsion systems based on it. For this to be accomplished thermoanalytical methods (differential scanning calorimetry and thermogravimetric analysis) coupled with microscopy, rheological, X-ray diffraction methods and a short-term in vivo study of skin hydration level were performed. Obtained results have proved that C-20/C-22 alkyl polyglucoside mixed emulsifier is able to provide the synergism between the two main types of lamellar phases, the liquid-crystalline (L alpha), and the gel crystalline (L beta) one, building the emulsion systems of different stability and performance. Formation of lamellar structures influenced for more than one half of water within the system to be entrapped. Conducted investigation of hydration potential in real-time conditions provided valuable information on the investigated emulsion vehicles' moisturizing potential as well as their contribution to the skin barrier improvement. Therefore, it could be expected that emulsions based on this alkyl polyglucoside emulsifier could influence the delivery of active ingredients of both the lipophilic and hydrophilic type. The employment of thermoanalytical methods in our work suggests the possibility for thermal methods to be used more frequently in the characterization of both the novel raw materials and the belonging emulsion systems.",
publisher = "Springer, Dordrecht",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development",
volume = "111",
number = "3",
pages = "2045-2057",
doi = "10.1007/s10973-012-2263-0"
}

Lukić, M., Pantelić, I., Daniels, R., Mueller-Goymann, C., Savić, M.,& Savić, S.. (2013). Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development. in Journal of Thermal Analysis and Calorimetry
Springer, Dordrecht., 111(3), 2045-2057.
https://doi.org/10.1007/s10973-012-2263-0

Lukić M, Pantelić I, Daniels R, Mueller-Goymann C, Savić M, Savić S. Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development. in Journal of Thermal Analysis and Calorimetry. 2013;111(3):2045-2057.
doi:10.1007/s10973-012-2263-0 .

Lukić, Milica, Pantelić, Ivana, Daniels, Rolf, Mueller-Goymann, Christel, Savić, Miroslav, Savić, Snežana, "Moisturizing emulsion systems based on the novel long-chain alkyl polyglucoside emulsifier The contribution of thermoanalytical methods to the formulation development" in Journal of Thermal Analysis and Calorimetry, 111, no. 3 (2013):2045-2057,
https://doi.org/10.1007/s10973-012-2263-0 . .

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Malenović, Anđelija
AU  - Reichl, Stephan
AU  - Hoffmann, Christine
AU  - Mueller-Goymann, Christel
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1721
AB  - Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutics and Biopharmaceutics
T1  - Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study
VL  - 80
IS  - 1
SP  - 164
EP  - 175
DO  - 10.1016/j.ejpb.2011.09.001
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Malenović, Anđelija and Reichl, Stephan and Hoffmann, Christine and Mueller-Goymann, Christel and Daniels, Rolf and Savić, Snežana",
year = "2012",
abstract = "Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
title = "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study",
volume = "80",
number = "1",
pages = "164-175",
doi = "10.1016/j.ejpb.2011.09.001"
}

Pantelić, I., Lukić, M., Malenović, A., Reichl, S., Hoffmann, C., Mueller-Goymann, C., Daniels, R.,& Savić, S.. (2012). Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics
Elsevier Science BV, Amsterdam., 80(1), 164-175.
https://doi.org/10.1016/j.ejpb.2011.09.001

Pantelić I, Lukić M, Malenović A, Reichl S, Hoffmann C, Mueller-Goymann C, Daniels R, Savić S. Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics. 2012;80(1):164-175.
doi:10.1016/j.ejpb.2011.09.001 .

Pantelić, Ivana, Lukić, Milica, Malenović, Anđelija, Reichl, Stephan, Hoffmann, Christine, Mueller-Goymann, Christel, Daniels, Rolf, Savić, Snežana, "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study" in European Journal of Pharmaceutics and Biopharmaceutics, 80, no. 1 (2012):164-175,
https://doi.org/10.1016/j.ejpb.2011.09.001 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Reichl, Stephan
AU  - Tamburić, Slobodanka
AU  - Mueller-Goymann, Christel
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1533
AB  - To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Colloid and Interface Science
T1  - An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential
VL  - 358
IS  - 1
SP  - 182
EP  - 191
DO  - 10.1016/j.jcis.2011.02.049
ER  - 

@article{
author = "Savić, Snežana and Lukić, Milica and Pantelić, Ivana and Reichl, Stephan and Tamburić, Slobodanka and Mueller-Goymann, Christel",
year = "2011",
abstract = "To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Colloid and Interface Science",
title = "An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential",
volume = "358",
number = "1",
pages = "182-191",
doi = "10.1016/j.jcis.2011.02.049"
}

Savić, S., Lukić, M., Pantelić, I., Reichl, S., Tamburić, S.,& Mueller-Goymann, C.. (2011). An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. in Journal of Colloid and Interface Science
Academic Press Inc Elsevier Science, San Diego., 358(1), 182-191.
https://doi.org/10.1016/j.jcis.2011.02.049

Savić S, Lukić M, Pantelić I, Reichl S, Tamburić S, Mueller-Goymann C. An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. in Journal of Colloid and Interface Science. 2011;358(1):182-191.
doi:10.1016/j.jcis.2011.02.049 .

Savić, Snežana, Lukić, Milica, Pantelić, Ivana, Reichl, Stephan, Tamburić, Slobodanka, Mueller-Goymann, Christel, "An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential" in Journal of Colloid and Interface Science, 358, no. 1 (2011):182-191,
https://doi.org/10.1016/j.jcis.2011.02.049 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Weber, Christian
AU  - Tamburić, Slobodanka
AU  - Savić, Miroslav
AU  - Mueller-Goymann, Christel
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1272
AB  - There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.
PB  - Elsevier Science Inc, New York
T2  - Journal of Pharmaceutical Sciences
T1  - Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance
VL  - 98
IS  - 6
SP  - 2073
EP  - 2090
DO  - 10.1002/jps.21591
ER  - 

@article{
author = "Savić, Snežana and Weber, Christian and Tamburić, Slobodanka and Savić, Miroslav and Mueller-Goymann, Christel",
year = "2009",
abstract = "There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the Colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. Furthermore, the study was concerned with the effect of these changes on in vitro permeation profiles of two model drugs (diclofenac sodium and caffeine) and in vivo skin performance of the test samples. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. PG addition produced a stronger hydrophilic lamellar gel phase than GL, which was independent on the model drug used. PG-containing vehicles have revealed a considerable amount of interlamellar PG/water mixture, with incorporated drug. In vitro permeation data obtained using artificial skill constructs (ASC) confirmed the relationship between rheological profiles of vehicles and the extent of skill delivery. Higher permeation profiles of both drugs from PG-containing formulations coincided with a higher increase in transepidermal water loss observed in in vivo study on human volunteers, which confirms the penetration/permeation enhancer effect of PG. It also indicates the existence of the vehicle/ASC interactions analogous to those between the vehicle and the skin, thus affirming the use of ASC as a reliable tool for permeation studies. Contrary to the effect of PG, the results obtained with GL suggest that it may have a permeation-retarding rather than a permeation-enhancing effect ill topical vehicles of this type.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Pharmaceutical Sciences",
title = "Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance",
volume = "98",
number = "6",
pages = "2073-2090",
doi = "10.1002/jps.21591"
}

Savić, S., Weber, C., Tamburić, S., Savić, M.,& Mueller-Goymann, C.. (2009). Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance. in Journal of Pharmaceutical Sciences
Elsevier Science Inc, New York., 98(6), 2073-2090.
https://doi.org/10.1002/jps.21591

Savić S, Weber C, Tamburić S, Savić M, Mueller-Goymann C. Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance. in Journal of Pharmaceutical Sciences. 2009;98(6):2073-2090.
doi:10.1002/jps.21591 .

Savić, Snežana, Weber, Christian, Tamburić, Slobodanka, Savić, Miroslav, Mueller-Goymann, Christel, "Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance" in Journal of Pharmaceutical Sciences, 98, no. 6 (2009):2073-2090,
https://doi.org/10.1002/jps.21591 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Weber, Christian
AU  - Savić, Miroslav
AU  - Mueller-Goymann, Christel
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1207
AB  - This study focuses on the properties of topical vehicles based on alkylpolyglucoside natural surfactant-mixed emulsifier, cetearyl glucoside and cetearyl alcohol, in order to propose their use as "ready to use" pharmaceutical bases for a number of model drugs. We were interested to investigate how the alternative use of three lipophilic excipients (Ph. Eur. 6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water. Finally, we aimed to evaluate the safety profile of such vehicles in vitro (acute skin irritation test using a cytotoxicity assay), comparing it with in vivo data obtained by the methods of skin bioengineering. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. Varying of lipophilic excipient influenced noteworthy variations in the colloidal structure demonstrated as different theological profiles accompanied to the certain degree by different water distribution modes, but notably provoked by drug nature (an amphiphilic electrolyte drug vs. nonelectrolyte). In vitro permeation data obtained using ASC membranes in an infinite dose-type of experiment stressed the importance of the vehicle/solute interactions in case of small variation in formulation composition, asserting the drug properties in the first hours of permeation and theological profile of the vehicles in the later phase of experiment as decisive factors. In vitro skin irritation test demonstrated a mild nature of the emulsifying wax and the absence of negative effects of used oil phases on cell viability in formulation concentrations correspondent to the therapeutic need. This result alongside with data obtained from in vivo study, could additionally promote investigated topical vehicles as prospective "ready to use" pharmaceutical bases.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance
VL  - 381
IS  - 2
SP  - 220
EP  - 230
DO  - 10.1016/j.ijpharm.2009.07.007
ER  - 

@article{
author = "Savić, Snežana and Weber, Christian and Savić, Miroslav and Mueller-Goymann, Christel",
year = "2009",
abstract = "This study focuses on the properties of topical vehicles based on alkylpolyglucoside natural surfactant-mixed emulsifier, cetearyl glucoside and cetearyl alcohol, in order to propose their use as "ready to use" pharmaceutical bases for a number of model drugs. We were interested to investigate how the alternative use of three lipophilic excipients (Ph. Eur. 6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water. Finally, we aimed to evaluate the safety profile of such vehicles in vitro (acute skin irritation test using a cytotoxicity assay), comparing it with in vivo data obtained by the methods of skin bioengineering. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type. Varying of lipophilic excipient influenced noteworthy variations in the colloidal structure demonstrated as different theological profiles accompanied to the certain degree by different water distribution modes, but notably provoked by drug nature (an amphiphilic electrolyte drug vs. nonelectrolyte). In vitro permeation data obtained using ASC membranes in an infinite dose-type of experiment stressed the importance of the vehicle/solute interactions in case of small variation in formulation composition, asserting the drug properties in the first hours of permeation and theological profile of the vehicles in the later phase of experiment as decisive factors. In vitro skin irritation test demonstrated a mild nature of the emulsifying wax and the absence of negative effects of used oil phases on cell viability in formulation concentrations correspondent to the therapeutic need. This result alongside with data obtained from in vivo study, could additionally promote investigated topical vehicles as prospective "ready to use" pharmaceutical bases.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance",
volume = "381",
number = "2",
pages = "220-230",
doi = "10.1016/j.ijpharm.2009.07.007"
}

Savić, S., Weber, C., Savić, M.,& Mueller-Goymann, C.. (2009). Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 381(2), 220-230.
https://doi.org/10.1016/j.ijpharm.2009.07.007

Savić S, Weber C, Savić M, Mueller-Goymann C. Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. in International Journal of Pharmaceutics. 2009;381(2):220-230.
doi:10.1016/j.ijpharm.2009.07.007 .

Savić, Snežana, Weber, Christian, Savić, Miroslav, Mueller-Goymann, Christel, "Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance" in International Journal of Pharmaceutics, 381, no. 2 (2009):220-230,
https://doi.org/10.1016/j.ijpharm.2009.07.007 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Tamburić, Slobodanka
AU  - Kovacević, Anđelka
AU  - Daniels, Rolf
AU  - Mueller-Goymann, Christel
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1034
AB  - There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-crystalline (L alpha) and complex lamellar gel (L beta) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Dispersion Science and Technology
T1  - Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability
VL  - 29
IS  - 9
SP  - 1276
EP  - 1287
DO  - 10.1080/01932690701857558
ER  - 

@article{
author = "Savić, Snežana and Tamburić, Slobodanka and Kovacević, Anđelka and Daniels, Rolf and Mueller-Goymann, Christel",
year = "2008",
abstract = "There is a growing need for research into new skin- and environment-friendly surfactants. The aim of the study was to find out whether a combination of an alkylpolyglucoside natural surfactant with established pharmaceutical excipients could provide a solid pharmaceutical base with satisfied physical stability. The study was carried out in two phases: the first one focused on the colloidal structure of vehicles formulated with oils of different polarity and/or different costabilizer (lipophilic versus hydrophilic) and the second one evaluated vehicles' physical stability. A number of techniques were used (polarization, light, and transmission electron microscopy, pH, conductivity and thermogravimetric measurements, rheological analysis and cyclic temperature stress test). Natural surfactant's interaction with used excipients resulted in the formation of semisolid emulsion systems of different rheological profiles, stabilized predominantly by synergistic effects of lamellar liquid-crystalline (L alpha) and complex lamellar gel (L beta) phases. The type of used oil and costabilizer significantly influenced the colloidal structure of the vehicles, particularly in terms of water distribution mode and initial rheological performance as well as their physical stability. It was recommended that medium polar oils of ester type and lipophilic costabilizers, particularly long chain fatty alcohols, should be used in the formulation of stable alkylpolyglucoside-based topical vehicles.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Dispersion Science and Technology",
title = "Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability",
volume = "29",
number = "9",
pages = "1276-1287",
doi = "10.1080/01932690701857558"
}

Savić, S., Tamburić, S., Kovacević, A., Daniels, R.,& Mueller-Goymann, C.. (2008). Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability. in Journal of Dispersion Science and Technology
Taylor & Francis Inc, Philadelphia., 29(9), 1276-1287.
https://doi.org/10.1080/01932690701857558

Savić S, Tamburić S, Kovacević A, Daniels R, Mueller-Goymann C. Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability. in Journal of Dispersion Science and Technology. 2008;29(9):1276-1287.
doi:10.1080/01932690701857558 .

Savić, Snežana, Tamburić, Slobodanka, Kovacević, Anđelka, Daniels, Rolf, Mueller-Goymann, Christel, "Natural Surfactant-Based Emulsion Systems: The Influence of Common Pharmaceutical Excipients on Colloidal Structure and Physical Stability" in Journal of Dispersion Science and Technology, 29, no. 9 (2008):1276-1287,
https://doi.org/10.1080/01932690701857558 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Savić, M.
AU  - Tamburić, Slobodanka
AU  - Vuleta, G.
AU  - Vesić, Sonja
AU  - Mueller-Goymann, Christel
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/939
AB  - There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation
VL  - 30
IS  - 5
SP  - 441
EP  - 450
DO  - 10.1016/j.ejps.2007.01.006
ER  - 

@article{
author = "Savić, Snežana and Savić, M. and Tamburić, Slobodanka and Vuleta, G. and Vesić, Sonja and Mueller-Goymann, Christel",
year = "2007",
abstract = "There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum. hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration. There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation",
volume = "30",
number = "5",
pages = "441-450",
doi = "10.1016/j.ejps.2007.01.006"
}

Savić, S., Savić, M., Tamburić, S., Vuleta, G., Vesić, S.,& Mueller-Goymann, C.. (2007). An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 30(5), 441-450.
https://doi.org/10.1016/j.ejps.2007.01.006

Savić S, Savić M, Tamburić S, Vuleta G, Vesić S, Mueller-Goymann C. An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation. in European Journal of Pharmaceutical Sciences. 2007;30(5):441-450.
doi:10.1016/j.ejps.2007.01.006 .

Savić, Snežana, Savić, M., Tamburić, Slobodanka, Vuleta, G., Vesić, Sonja, Mueller-Goymann, Christel, "An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation" in European Journal of Pharmaceutical Sciences, 30, no. 5 (2007):441-450,
https://doi.org/10.1016/j.ejps.2007.01.006 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Savić, Miroslav
AU  - Vesić, Sonja
AU  - Vuleta, Gordana
AU  - Mueller-Goymann, Christel
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/691
AB  - An emerging class of natural surfactants, named alkylpolyglucosides, which can form both, the thermotropic and the lyotropic, liquid crystalline phases, were focused. The aim of the study was to integrate some physicochemical properties (characterised through the polarization and transmission electron microscopy, wide-angle X-ray diffraction, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, with the in vitro (the artificial skin constructs) and in vivo bioavailability of hydrocortisone (HQ, in comparison with a standard pharmacopoeial vehicle. The parameters measured in vivo were erythema index (an instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum hydration. A complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type was deduced for sugar surfactant-based vehicles. In dependence on surfactant/water/oil ratio, several thermodinamically variable fractions of water were predicted. Rheological profile of the vehicle appeared to influence the in vitro profile of permeation. A surplus of total amount of drug permeated in vitro from the alkylpolyglucoside-based vehicles coincided with the more pronounced increase of TEWL and less marked blanching action of HC from the selected alkylpolyglucoside-based vehicle tested in vivo, related to the pharmacopoeial one. These findings imply an enhanced delivery of HC from this vehicle and its putative penetration enhancing effect, probably dependent on specific distribution of the vehicle's inherent water.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation
VL  - 320
IS  - 1-2
SP  - 86
EP  - 95
DO  - 10.1016/j.ijpharm.2006.04.019
ER  - 

@article{
author = "Savić, Snežana and Savić, Miroslav and Vesić, Sonja and Vuleta, Gordana and Mueller-Goymann, Christel",
year = "2006",
abstract = "An emerging class of natural surfactants, named alkylpolyglucosides, which can form both, the thermotropic and the lyotropic, liquid crystalline phases, were focused. The aim of the study was to integrate some physicochemical properties (characterised through the polarization and transmission electron microscopy, wide-angle X-ray diffraction, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, with the in vitro (the artificial skin constructs) and in vivo bioavailability of hydrocortisone (HQ, in comparison with a standard pharmacopoeial vehicle. The parameters measured in vivo were erythema index (an instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum hydration. A complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type was deduced for sugar surfactant-based vehicles. In dependence on surfactant/water/oil ratio, several thermodinamically variable fractions of water were predicted. Rheological profile of the vehicle appeared to influence the in vitro profile of permeation. A surplus of total amount of drug permeated in vitro from the alkylpolyglucoside-based vehicles coincided with the more pronounced increase of TEWL and less marked blanching action of HC from the selected alkylpolyglucoside-based vehicle tested in vivo, related to the pharmacopoeial one. These findings imply an enhanced delivery of HC from this vehicle and its putative penetration enhancing effect, probably dependent on specific distribution of the vehicle's inherent water.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation",
volume = "320",
number = "1-2",
pages = "86-95",
doi = "10.1016/j.ijpharm.2006.04.019"
}

Savić, S., Savić, M., Vesić, S., Vuleta, G.,& Mueller-Goymann, C.. (2006). Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 320(1-2), 86-95.
https://doi.org/10.1016/j.ijpharm.2006.04.019

Savić S, Savić M, Vesić S, Vuleta G, Mueller-Goymann C. Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation. in International Journal of Pharmaceutics. 2006;320(1-2):86-95.
doi:10.1016/j.ijpharm.2006.04.019 .

Savić, Snežana, Savić, Miroslav, Vesić, Sonja, Vuleta, Gordana, Mueller-Goymann, Christel, "Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation" in International Journal of Pharmaceutics, 320, no. 1-2 (2006):86-95,
https://doi.org/10.1016/j.ijpharm.2006.04.019 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Vuleta, G
AU  - Daniels, Rolf
AU  - Mueller-Goymann, Christel
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/625
AB  - The aim of this study was to examine the lyotropic potential of an alkylpolyglucoside mixed emulsifier (Cetearyl glucoside&Cetearyl alcohol), which belongs to the new generation of natural (sugar) surfactants, and to elaborate the potential stabilization mechanism and relation between the colloid microstructure and water distribution within the systems. Polarization and ordinary light as well as transmission electron microscopy, wide and small-angle X-ray diffraction, thermal analysis and rheological measurement were employed for the systems characterization. It was suggested that Cetearyl glucoside&Cetearyl alcohol stabilizes the o/w creams by synergistic effects of viscoelastic hydrophilic gel of lamellar type and lipophilic gel network built up from cetostearyl alcohol semi-hydrates as well as by lamellar liquid crystalline bilayers surrounding the oil droplets. The hydrophilic gel consists of mixed cetearyl glucoside/cetearyl alcohol crystalline bilayers entrapping the water interlamellarly by hydrogen bonding. It is also showed that oil addition into the chosen binary system influences the creams microstructure significantly, which particularly reflects onto the mode of water distribution within the creams and consequently their potential of skin hydration.
PB  - Springer, New York
T2  - Colloid and Polymer Science
T1  - Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier
VL  - 283
IS  - 4
SP  - 439
EP  - 451
DO  - 10.1007/s00396-004-1174-4
ER  - 

@article{
author = "Savić, Snežana and Vuleta, G and Daniels, Rolf and Mueller-Goymann, Christel",
year = "2005",
abstract = "The aim of this study was to examine the lyotropic potential of an alkylpolyglucoside mixed emulsifier (Cetearyl glucoside&Cetearyl alcohol), which belongs to the new generation of natural (sugar) surfactants, and to elaborate the potential stabilization mechanism and relation between the colloid microstructure and water distribution within the systems. Polarization and ordinary light as well as transmission electron microscopy, wide and small-angle X-ray diffraction, thermal analysis and rheological measurement were employed for the systems characterization. It was suggested that Cetearyl glucoside&Cetearyl alcohol stabilizes the o/w creams by synergistic effects of viscoelastic hydrophilic gel of lamellar type and lipophilic gel network built up from cetostearyl alcohol semi-hydrates as well as by lamellar liquid crystalline bilayers surrounding the oil droplets. The hydrophilic gel consists of mixed cetearyl glucoside/cetearyl alcohol crystalline bilayers entrapping the water interlamellarly by hydrogen bonding. It is also showed that oil addition into the chosen binary system influences the creams microstructure significantly, which particularly reflects onto the mode of water distribution within the creams and consequently their potential of skin hydration.",
publisher = "Springer, New York",
journal = "Colloid and Polymer Science",
title = "Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier",
volume = "283",
number = "4",
pages = "439-451",
doi = "10.1007/s00396-004-1174-4"
}

Savić, S., Vuleta, G., Daniels, R.,& Mueller-Goymann, C.. (2005). Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier. in Colloid and Polymer Science
Springer, New York., 283(4), 439-451.
https://doi.org/10.1007/s00396-004-1174-4

Savić S, Vuleta G, Daniels R, Mueller-Goymann C. Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier. in Colloid and Polymer Science. 2005;283(4):439-451.
doi:10.1007/s00396-004-1174-4 .

Savić, Snežana, Vuleta, G, Daniels, Rolf, Mueller-Goymann, Christel, "Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier" in Colloid and Polymer Science, 283, no. 4 (2005):439-451,
https://doi.org/10.1007/s00396-004-1174-4 . .