TY  - JOUR
AU  - Knežević, A
AU  - Živković, Lada
AU  - Stajić, Mirjana
AU  - Vukojević, Jelena
AU  - Milovanović, I
AU  - Potparević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2495
AB  - Trametes species have been used for thousands of years in traditional and conventional medicine for the treatment of various types of diseases. The goal was to evaluate possible antigenotoxic effects of mycelium and basidiocarp extracts of selected Trametes species and to assess dependence on their antioxidant potential. Trametes versicolor, T. hirsuta, and T. gibbosa were the species studied. Antigenotoxic potentials of extracts were assessed on human peripheral white blood cells with basidiocarp and mycelium extracts of the species. The alkaline comet test was used for detection of DNA strand breaks and alkali-labile sites, as well as the extent of DNA migration. DPPH assay was used to estimate antioxidative properties of extracts. Fruiting body extracts of T. versicolor and T. gibbosa as well as T. hirsuta extracts, except that at 20.0 mg/mL, were not genotoxic agents. T. versicolor extract had at 5.0 mg/mL the greatest antigenotoxic effect in both pre-and posttreatment of leukocytes. The mycelium extracts of the three species had no genotoxic activity and significant antigenotoxic effect against H lt inf>2 lt /inf>O lt inf>2 lt /inf>-induced DNA damage, both in pre-and posttreatment. The results suggest that extracts of these three species could be considered as strong antigenotoxic agents able to stimulate genoprotective response of cells.
PB  - Hindawi Publishing Corporation
T2  - Scientific World Journal
T1  - Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells
VL  - 2015
DO  - 10.1155/2015/146378
ER  - 

@article{
author = "Knežević, A and Živković, Lada and Stajić, Mirjana and Vukojević, Jelena and Milovanović, I and Potparević, Biljana",
year = "2015",
abstract = "Trametes species have been used for thousands of years in traditional and conventional medicine for the treatment of various types of diseases. The goal was to evaluate possible antigenotoxic effects of mycelium and basidiocarp extracts of selected Trametes species and to assess dependence on their antioxidant potential. Trametes versicolor, T. hirsuta, and T. gibbosa were the species studied. Antigenotoxic potentials of extracts were assessed on human peripheral white blood cells with basidiocarp and mycelium extracts of the species. The alkaline comet test was used for detection of DNA strand breaks and alkali-labile sites, as well as the extent of DNA migration. DPPH assay was used to estimate antioxidative properties of extracts. Fruiting body extracts of T. versicolor and T. gibbosa as well as T. hirsuta extracts, except that at 20.0 mg/mL, were not genotoxic agents. T. versicolor extract had at 5.0 mg/mL the greatest antigenotoxic effect in both pre-and posttreatment of leukocytes. The mycelium extracts of the three species had no genotoxic activity and significant antigenotoxic effect against H lt inf>2 lt /inf>O lt inf>2 lt /inf>-induced DNA damage, both in pre-and posttreatment. The results suggest that extracts of these three species could be considered as strong antigenotoxic agents able to stimulate genoprotective response of cells.",
publisher = "Hindawi Publishing Corporation",
journal = "Scientific World Journal",
title = "Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells",
volume = "2015",
doi = "10.1155/2015/146378"
}

Knežević, A., Živković, L., Stajić, M., Vukojević, J., Milovanović, I.,& Potparević, B.. (2015). Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells. in Scientific World Journal
Hindawi Publishing Corporation., 2015.
https://doi.org/10.1155/2015/146378

Knežević A, Živković L, Stajić M, Vukojević J, Milovanović I, Potparević B. Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells. in Scientific World Journal. 2015;2015.
doi:10.1155/2015/146378 .

Knežević, A, Živković, Lada, Stajić, Mirjana, Vukojević, Jelena, Milovanović, I, Potparević, Biljana, "Antigenotoxic Effect of Trametes spp. Extracts against DNA Damage on Human Peripheral White Blood Cells" in Scientific World Journal, 2015 (2015),
https://doi.org/10.1155/2015/146378 . .

TY  - JOUR
AU  - Nežić, D.
AU  - Milojević, Predrag
AU  - Ćirković, M.
AU  - Knežević, A.
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Jović, M.
AU  - Đukanović, B.
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/630
AB  - Coronary artery bypass grafting (CABG) is the standard surgical procedure for the treatment of advanced coronary artery disease. CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life. Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used. Previous long-term studies have shown unsatisfactory patency of saphenous vein grafts used for myocardial revascularisation, compared with internal mammary artery grafts. Recently, the use of radial artery for CABG has enjoyed a revival, on the basis of the belief that it will help improving long-term results of coronary operations. The recent reports of encouraging mid-term and long-term patency rates of the radial artery, supports its continued use as a bypass conduit. In this paper, we review the current knowledge about the radial artery as a bypass graft, with special emphasis on the clinical results.
AB  - Hirurška revaskularizacija miokarda je standardna procedura u tretmanu uznapredovale koronarne bolesti. Dokazano je da koronarna hirurgija uklanja simptome i produžava život određenih kategorija koronarnih bolesnika. Dugotrajni rezultati hirurške revaskularizacije miokarda u velikoj meri ovise o promenama koje se vremenom javljaju na upotrebljenom graftu. Studije dugoročnog praćenja operisanih bolesnika potvrdile su izuzetan kvalitet i prednost grafta unutarnje torakalne arterije u odnosu na venski graft. U skorije vreme obnovljeno je interesovanje za graft radijalne arterije, sa uverenjem da će njegova primena omogućiti bolje dugoročne rezultate. U poslednje vreme prikazani su radovi koji potvrđuju izuzetnu kratkoročnu i dugoročnu prohodnost grafta radijalne arterije i govore u prilog intenzivnije primene toga grafta u hirurškoj revaskularizaciji miokarda. Na prikaz je pregled sadanjih saznanja o radijalnoj arteriji kao graftu u kardiohirurgiji, sa posebnim osvrtom na kliničke rezultate.
PB  - Udruženje hirurga Jugoslavije, Beograd
T2  - Acta chirurgica iugoslavica
T1  - The radial artery for coronary artery bypass grafting
VL  - 52
IS  - 3
SP  - 11
EP  - 19
DO  - 10.2298/ACI0503011N
ER  - 

@article{
author = "Nežić, D. and Milojević, Predrag and Ćirković, M. and Knežević, A. and Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Jović, M. and Đukanović, B.",
year = "2005",
abstract = "Coronary artery bypass grafting (CABG) is the standard surgical procedure for the treatment of advanced coronary artery disease. CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life. Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used. Previous long-term studies have shown unsatisfactory patency of saphenous vein grafts used for myocardial revascularisation, compared with internal mammary artery grafts. Recently, the use of radial artery for CABG has enjoyed a revival, on the basis of the belief that it will help improving long-term results of coronary operations. The recent reports of encouraging mid-term and long-term patency rates of the radial artery, supports its continued use as a bypass conduit. In this paper, we review the current knowledge about the radial artery as a bypass graft, with special emphasis on the clinical results., Hirurška revaskularizacija miokarda je standardna procedura u tretmanu uznapredovale koronarne bolesti. Dokazano je da koronarna hirurgija uklanja simptome i produžava život određenih kategorija koronarnih bolesnika. Dugotrajni rezultati hirurške revaskularizacije miokarda u velikoj meri ovise o promenama koje se vremenom javljaju na upotrebljenom graftu. Studije dugoročnog praćenja operisanih bolesnika potvrdile su izuzetan kvalitet i prednost grafta unutarnje torakalne arterije u odnosu na venski graft. U skorije vreme obnovljeno je interesovanje za graft radijalne arterije, sa uverenjem da će njegova primena omogućiti bolje dugoročne rezultate. U poslednje vreme prikazani su radovi koji potvrđuju izuzetnu kratkoročnu i dugoročnu prohodnost grafta radijalne arterije i govore u prilog intenzivnije primene toga grafta u hirurškoj revaskularizaciji miokarda. Na prikaz je pregled sadanjih saznanja o radijalnoj arteriji kao graftu u kardiohirurgiji, sa posebnim osvrtom na kliničke rezultate.",
publisher = "Udruženje hirurga Jugoslavije, Beograd",
journal = "Acta chirurgica iugoslavica",
title = "The radial artery for coronary artery bypass grafting",
volume = "52",
number = "3",
pages = "11-19",
doi = "10.2298/ACI0503011N"
}

Nežić, D., Milojević, P., Ćirković, M., Knežević, A., Novaković, A., Gojković-Bukarica, L., Jović, M.,& Đukanović, B.. (2005). The radial artery for coronary artery bypass grafting. in Acta chirurgica iugoslavica
Udruženje hirurga Jugoslavije, Beograd., 52(3), 11-19.
https://doi.org/10.2298/ACI0503011N

Nežić D, Milojević P, Ćirković M, Knežević A, Novaković A, Gojković-Bukarica L, Jović M, Đukanović B. The radial artery for coronary artery bypass grafting. in Acta chirurgica iugoslavica. 2005;52(3):11-19.
doi:10.2298/ACI0503011N .

Nežić, D., Milojević, Predrag, Ćirković, M., Knežević, A., Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Jović, M., Đukanović, B., "The radial artery for coronary artery bypass grafting" in Acta chirurgica iugoslavica, 52, no. 3 (2005):11-19,
https://doi.org/10.2298/ACI0503011N . .