TY  - JOUR
AU  - Mudrić, Jelena
AU  - Janković, Teodora
AU  - Šavikin, Katarina
AU  - Bigović, Dubravka
AU  - Đukić-Ćosić, Danijela
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3636
AB  - Perennial plant Gentiana lutea L. is used worldwide for the preparation of pharmaceutical and food products. Health benefits of G. lutea roots are associated with the presence of major bitter-tasting secoiridoid gentiopicroside and xanthone isogentisin. The aim was to optimize the heat-assisted extraction of gentipicroside (GP), isogentisin (ISG) and total phenolics (TP) from G. lutea roots and develop models with high accuracy and prediction capacity by response surface methodology (RSM) and artificial neural networks (ANN). Extracts were prepared according to central composite design. Significant independent variables which were previously identified by Plackett-Burman screening design were varied at five levels - temperature (20−80 °C), time (8−180 min), solid-to-solvent ratio (1:10−1:50) and ethanol concentration (10–70 %). Contents of GP, ISG (by HPLC-DAD) and TP (by Folin–Ciocalteu method) were analyzed. The optimal conditions for the extraction were temperature of 65 °C, time of 129.08 min, solid-to-solvent ratio of 1:40, and ethanol concentration 49.33 %. Under these conditions, experimentally obtained results for GP (18.03 mg/g dw), ISG (8.15 mg/g dw) and TP (17.46 mg of gallic acid equivalents/g dw) content were in agreement with the values predicted by RSM and ANN. Comparison of models through the coefficient of determination (R2) and the root mean square error (RMSE) showed that ANN approach was superior to RSM in predicting and modelling GP, ISG and TP content, simultaneously. Effective heat-assisted extraction method for the extraction of GP, ISG and TP from the roots of G. lutea was designed, and models with high accuracy and good prediction capacity were developed.
PB  - Elsevier B.V.
T2  - Industrial Crops and Products
T1  - Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots
VL  - 155
DO  - 10.1016/j.indcrop.2020.112767
ER  - 

@article{
author = "Mudrić, Jelena and Janković, Teodora and Šavikin, Katarina and Bigović, Dubravka and Đukić-Ćosić, Danijela and Ibrić, Svetlana and Đuriš, Jelena",
year = "2020",
abstract = "Perennial plant Gentiana lutea L. is used worldwide for the preparation of pharmaceutical and food products. Health benefits of G. lutea roots are associated with the presence of major bitter-tasting secoiridoid gentiopicroside and xanthone isogentisin. The aim was to optimize the heat-assisted extraction of gentipicroside (GP), isogentisin (ISG) and total phenolics (TP) from G. lutea roots and develop models with high accuracy and prediction capacity by response surface methodology (RSM) and artificial neural networks (ANN). Extracts were prepared according to central composite design. Significant independent variables which were previously identified by Plackett-Burman screening design were varied at five levels - temperature (20−80 °C), time (8−180 min), solid-to-solvent ratio (1:10−1:50) and ethanol concentration (10–70 %). Contents of GP, ISG (by HPLC-DAD) and TP (by Folin–Ciocalteu method) were analyzed. The optimal conditions for the extraction were temperature of 65 °C, time of 129.08 min, solid-to-solvent ratio of 1:40, and ethanol concentration 49.33 %. Under these conditions, experimentally obtained results for GP (18.03 mg/g dw), ISG (8.15 mg/g dw) and TP (17.46 mg of gallic acid equivalents/g dw) content were in agreement with the values predicted by RSM and ANN. Comparison of models through the coefficient of determination (R2) and the root mean square error (RMSE) showed that ANN approach was superior to RSM in predicting and modelling GP, ISG and TP content, simultaneously. Effective heat-assisted extraction method for the extraction of GP, ISG and TP from the roots of G. lutea was designed, and models with high accuracy and good prediction capacity were developed.",
publisher = "Elsevier B.V.",
journal = "Industrial Crops and Products",
title = "Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots",
volume = "155",
doi = "10.1016/j.indcrop.2020.112767"
}

Mudrić, J., Janković, T., Šavikin, K., Bigović, D., Đukić-Ćosić, D., Ibrić, S.,& Đuriš, J.. (2020). Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots. in Industrial Crops and Products
Elsevier B.V.., 155.
https://doi.org/10.1016/j.indcrop.2020.112767

Mudrić J, Janković T, Šavikin K, Bigović D, Đukić-Ćosić D, Ibrić S, Đuriš J. Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots. in Industrial Crops and Products. 2020;155.
doi:10.1016/j.indcrop.2020.112767 .

Mudrić, Jelena, Janković, Teodora, Šavikin, Katarina, Bigović, Dubravka, Đukić-Ćosić, Danijela, Ibrić, Svetlana, Đuriš, Jelena, "Optimization and modelling of gentiopicroside, isogentisin and total phenolics extraction from Gentiana lutea L. roots" in Industrial Crops and Products, 155 (2020),
https://doi.org/10.1016/j.indcrop.2020.112767 . .

TY  - JOUR
AU  - Cujić, Nada
AU  - Šavikin, Katarina
AU  - Janković, Teodora
AU  - Pljevljakusić, Dejan
AU  - Zdunić, Gordana
AU  - Ibrić, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2582
AB  - Traditional maceration method was used for the extraction of polyphenols from chokeberry (Aronia melanocarpa) dried fruit, and the effects of several extraction parameters on the total phenolics and anthocyanins contents were studied. Various solvents, particle size, solid solvent ratio and extraction time have been investigated as independent variables in two level factorial design. Among examined variables, time was not statistically important factor for the extraction of polyphenols. The optimal extraction conditions were maceration of 0.75 mm size berries by 50% ethanol, with solid solvent ratio of 1:20, and predicted values were 27.7 mg GAE/g for total phenolics and 0.27% for total anthocyanins. Under selected conditions, the experimental total phenolics were 27.8 mg GAE/g, and total anthocyanins were 0.27%, which is in agreement with the predicted values. In addition, a complementary quantitative analysis of individual phenolic compounds was performed using HPLC method. The study indicated that maceration was effective and simple technique for the extraction of bioactive compounds from chokeberry fruit.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique
VL  - 194
SP  - 135
EP  - 142
DO  - 10.1016/j.foodchem.2015.08.008
ER  - 

@article{
author = "Cujić, Nada and Šavikin, Katarina and Janković, Teodora and Pljevljakusić, Dejan and Zdunić, Gordana and Ibrić, Svetlana",
year = "2016",
abstract = "Traditional maceration method was used for the extraction of polyphenols from chokeberry (Aronia melanocarpa) dried fruit, and the effects of several extraction parameters on the total phenolics and anthocyanins contents were studied. Various solvents, particle size, solid solvent ratio and extraction time have been investigated as independent variables in two level factorial design. Among examined variables, time was not statistically important factor for the extraction of polyphenols. The optimal extraction conditions were maceration of 0.75 mm size berries by 50% ethanol, with solid solvent ratio of 1:20, and predicted values were 27.7 mg GAE/g for total phenolics and 0.27% for total anthocyanins. Under selected conditions, the experimental total phenolics were 27.8 mg GAE/g, and total anthocyanins were 0.27%, which is in agreement with the predicted values. In addition, a complementary quantitative analysis of individual phenolic compounds was performed using HPLC method. The study indicated that maceration was effective and simple technique for the extraction of bioactive compounds from chokeberry fruit.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique",
volume = "194",
pages = "135-142",
doi = "10.1016/j.foodchem.2015.08.008"
}

Cujić, N., Šavikin, K., Janković, T., Pljevljakusić, D., Zdunić, G.,& Ibrić, S.. (2016). Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. in Food Chemistry
Elsevier Sci Ltd, Oxford., 194, 135-142.
https://doi.org/10.1016/j.foodchem.2015.08.008

Cujić N, Šavikin K, Janković T, Pljevljakusić D, Zdunić G, Ibrić S. Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique. in Food Chemistry. 2016;194:135-142.
doi:10.1016/j.foodchem.2015.08.008 .

Cujić, Nada, Šavikin, Katarina, Janković, Teodora, Pljevljakusić, Dejan, Zdunić, Gordana, Ibrić, Svetlana, "Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique" in Food Chemistry, 194 (2016):135-142,
https://doi.org/10.1016/j.foodchem.2015.08.008 . .

TY  - JOUR
AU  - Ignjatović, Đurđica
AU  - Živković, Jelena
AU  - Tovilović, Gordana
AU  - Šavikin, Katarina
AU  - Tomić, Mirko
AU  - Maksimović, Zoran
AU  - Janković, Teodora
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2393
AB  - Methanol and 70% acetone extracts from Veronica jacquinii, Veronica urticifolia and Veronica teucrium were evaluated regarding their neuroprotective/antioxidant effects on the human neuroblastoma SH-SY5Y cell line. All extracts exhibited modest protective activity by increasing cell survival in cells stressed with sodium nitroprusside (9-12%) and hydrogen peroxide (16-21%) compared to non-treated cells. These activities were accompanied by reductions in the amount of superoxide radicals and index of lipid peroxidation. Extracts were further analysed for the content of total phenolics, phenylpropanoid glycosides and iridoids, and the major compounds acteoside and aucubin. The highest amount of total phenolics was observed in V. jacquinii, while V. teucrium was richest in total iridoids, acteoside and aucubin. Angiogenic properties on EA.hy926 human endothelial cells were also examined. At the highest non-toxic concentration (25 mu g/ml), the tested extracts inhibited spontaneous tube formation of endothelial cells on the extracellular matrix, implying their possible antiangiogenic activity. The most potent inhibitory effects were shown by methanol extract of V. jacquinii and aqueous acetone extract of V. teucrium. The extracts did not significantly change the adhesive or migratory capacity of EA.hy926 cells. Considering the traditional use of Veronica species, these results suggest a need for further assessment of their supposed wound-healing properties.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Frontiers in Life Science
T1  - Evaluation of angiogenic and neuroprotective potential of different extracts from three Veronica species
VL  - 8
IS  - 2
SP  - 107
EP  - 116
DO  - 10.1080/21553769.2014.998297
ER  - 

@article{
author = "Ignjatović, Đurđica and Živković, Jelena and Tovilović, Gordana and Šavikin, Katarina and Tomić, Mirko and Maksimović, Zoran and Janković, Teodora",
year = "2015",
abstract = "Methanol and 70% acetone extracts from Veronica jacquinii, Veronica urticifolia and Veronica teucrium were evaluated regarding their neuroprotective/antioxidant effects on the human neuroblastoma SH-SY5Y cell line. All extracts exhibited modest protective activity by increasing cell survival in cells stressed with sodium nitroprusside (9-12%) and hydrogen peroxide (16-21%) compared to non-treated cells. These activities were accompanied by reductions in the amount of superoxide radicals and index of lipid peroxidation. Extracts were further analysed for the content of total phenolics, phenylpropanoid glycosides and iridoids, and the major compounds acteoside and aucubin. The highest amount of total phenolics was observed in V. jacquinii, while V. teucrium was richest in total iridoids, acteoside and aucubin. Angiogenic properties on EA.hy926 human endothelial cells were also examined. At the highest non-toxic concentration (25 mu g/ml), the tested extracts inhibited spontaneous tube formation of endothelial cells on the extracellular matrix, implying their possible antiangiogenic activity. The most potent inhibitory effects were shown by methanol extract of V. jacquinii and aqueous acetone extract of V. teucrium. The extracts did not significantly change the adhesive or migratory capacity of EA.hy926 cells. Considering the traditional use of Veronica species, these results suggest a need for further assessment of their supposed wound-healing properties.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Frontiers in Life Science",
title = "Evaluation of angiogenic and neuroprotective potential of different extracts from three Veronica species",
volume = "8",
number = "2",
pages = "107-116",
doi = "10.1080/21553769.2014.998297"
}

Ignjatović, Đ., Živković, J., Tovilović, G., Šavikin, K., Tomić, M., Maksimović, Z.,& Janković, T.. (2015). Evaluation of angiogenic and neuroprotective potential of different extracts from three Veronica species. in Frontiers in Life Science
Taylor & Francis Ltd, Abingdon., 8(2), 107-116.
https://doi.org/10.1080/21553769.2014.998297

Ignjatović Đ, Živković J, Tovilović G, Šavikin K, Tomić M, Maksimović Z, Janković T. Evaluation of angiogenic and neuroprotective potential of different extracts from three Veronica species. in Frontiers in Life Science. 2015;8(2):107-116.
doi:10.1080/21553769.2014.998297 .

Ignjatović, Đurđica, Živković, Jelena, Tovilović, Gordana, Šavikin, Katarina, Tomić, Mirko, Maksimović, Zoran, Janković, Teodora, "Evaluation of angiogenic and neuroprotective potential of different extracts from three Veronica species" in Frontiers in Life Science, 8, no. 2 (2015):107-116,
https://doi.org/10.1080/21553769.2014.998297 . .

TY  - JOUR
AU  - Beara, Ivana
AU  - Živković, Jelena
AU  - Lesjak, Marija
AU  - Ristić, Jelena
AU  - Šavikin, Katarina
AU  - Maksimović, Zoran
AU  - Janković, Teodora
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2377
AB  - Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae), Veronica jacquinii Baumg., Veronica teucrium L. and Veronica urticifolia Jacq was studied. The identification and quantification of 30 phenolic compounds in aqueous-acetone extracts were performed using LC-MS/MS technique, and the main components were baicalin, hyperoside, isoquercetine, chlorogenic acid and quinic acid. Genistein and baicalein were detected for the first time in Plantaginaceae family and Veronica genus, respectively. The anti-inflammatory potential of tested extracts was determined using calcium ionophore-stimulated human platelets as a source of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) enzymes, and highly sensitive and specific LC-MS/MS technique was performed for detection of the main arachidonic acid metabolites formed by them. V. urticifolia extract exerted the strongest COX-1 inhibition (IC50  lt  0.4 mg/mL), while V. jacquinii extract exhibited the highest ability to inhibit 12-LOX activity (IC50 = 1.072 mg/mL). The results obtained in this study may be used to promote better use of the genus Veronica as anti-inflammatory agents.
PB  - Elsevier Science BV, Amsterdam
T2  - Industrial Crops and Products
T1  - Phenolic profile and anti-inflammatory activity of three Veronica species
VL  - 63
SP  - 276
EP  - 280
DO  - 10.1016/j.indcrop.2014.09.034
ER  - 

@article{
author = "Beara, Ivana and Živković, Jelena and Lesjak, Marija and Ristić, Jelena and Šavikin, Katarina and Maksimović, Zoran and Janković, Teodora",
year = "2015",
abstract = "Aerial parts of some Veronica species are used as traditional medicine for treatment of various inflammatory conditions, including rheumatism. In the present study, phenolic content and anti-inflammatory activity of three Veronica species (Plantaginaceae), Veronica jacquinii Baumg., Veronica teucrium L. and Veronica urticifolia Jacq was studied. The identification and quantification of 30 phenolic compounds in aqueous-acetone extracts were performed using LC-MS/MS technique, and the main components were baicalin, hyperoside, isoquercetine, chlorogenic acid and quinic acid. Genistein and baicalein were detected for the first time in Plantaginaceae family and Veronica genus, respectively. The anti-inflammatory potential of tested extracts was determined using calcium ionophore-stimulated human platelets as a source of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) enzymes, and highly sensitive and specific LC-MS/MS technique was performed for detection of the main arachidonic acid metabolites formed by them. V. urticifolia extract exerted the strongest COX-1 inhibition (IC50  lt  0.4 mg/mL), while V. jacquinii extract exhibited the highest ability to inhibit 12-LOX activity (IC50 = 1.072 mg/mL). The results obtained in this study may be used to promote better use of the genus Veronica as anti-inflammatory agents.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Industrial Crops and Products",
title = "Phenolic profile and anti-inflammatory activity of three Veronica species",
volume = "63",
pages = "276-280",
doi = "10.1016/j.indcrop.2014.09.034"
}

Beara, I., Živković, J., Lesjak, M., Ristić, J., Šavikin, K., Maksimović, Z.,& Janković, T.. (2015). Phenolic profile and anti-inflammatory activity of three Veronica species. in Industrial Crops and Products
Elsevier Science BV, Amsterdam., 63, 276-280.
https://doi.org/10.1016/j.indcrop.2014.09.034

Beara I, Živković J, Lesjak M, Ristić J, Šavikin K, Maksimović Z, Janković T. Phenolic profile and anti-inflammatory activity of three Veronica species. in Industrial Crops and Products. 2015;63:276-280.
doi:10.1016/j.indcrop.2014.09.034 .

Beara, Ivana, Živković, Jelena, Lesjak, Marija, Ristić, Jelena, Šavikin, Katarina, Maksimović, Zoran, Janković, Teodora, "Phenolic profile and anti-inflammatory activity of three Veronica species" in Industrial Crops and Products, 63 (2015):276-280,
https://doi.org/10.1016/j.indcrop.2014.09.034 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Janković, Teodora
AU  - Maksimović, Zoran
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2011
AB  - In the present study, methanolic extracts of three Veronica species, namely Veronica montana, Veronica beccabunga and Veronica polita, were analyzed for the total iridoids, total phenylethanoids and total phenolics contents. The results showed that iridoid glycosides are the major class of tested secondary metabolites in selected Veronica species. The highest iridoid content (467.33 mg/g d.w.) was recorded in extract of V. polita, while the richest source of total phenolics and total phenylethanoids was the extract of V. montana (105.24 mg GAE/g d.w. and 16.03 mg acteoside/g d.w., respectively). Additionally, aucubin determination in tested extracts was performed by high-performance liquid chromatography (HPLC) and high-performance thin layer chromatography (HPTLC). The aucubin content in investigated samples determined by HPLC varied between 5.66 in extract of V. beccabunga and 69.96 mg/g d.w. in extract of V. polita. No significant differences were observed between the aucubin content in plant extracts obtained by HPLC and HPTLC techniques. The proposed HPTLC method is simple, rapid and more economical as compared to HPLC method, and thus it may be suitable for routine identification and quantification of aucubin in Veronica species.
AB  - U ovom radu, primenom spektrofotometrijskih metoda, određen je sadržaj ukupnih fenola, fenilpropanoida i iridoida u metanolnim ekstraktima herbi Veronica montana, V. beccabunga i V. polita. Rezultati spektofotometrijske analize pokazuju da su iridoidni glukozidi dominantna grupa sekundarnih metabolita u odabranim vrstama. Njihov sadržaj bio je najveći u herbi V. polita, dok je V. montana bila najbogatija ukupnim fenolima i ukupnim fenilpropanoidima. Dodatno, u ispitivanim ekstraktima kvantifikovan je aukubin primenom tehnika visoko-efikasne tečne hromatografije (HPLC) i visoko-efikasne tankoslojne hromatografije (HPTLC). Sadržaj aukubina određen primenom HPLC tehnike kretao se od 5,66 u ekstraktu V. beccabunga do 69,96 mg/g suve mase u ekstraktu V. polita. Iz rezultata dobijenih u ovom radu uočava se da nema statistički značajnih razlika između vrednosti za sadržaj aukubina dobijenih primenom HPLC i HPTLC tehnika. Predložena HPTLC metoda kao jednostavnija, ekonomičnija, sa mogućnošću analize više uzoraka istovremeno, može biti pogodna za rutinsku identifikaciju i kvantifikaciju aukubina u Veronica vrstama, kao i sastavni deo protokola za procenu autentičnosti biljnog materijala.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Determination of aucubin by HPLC and HPTLC methods in methanolic extracts of Veronica montana, Veronica beccabunga and Veronica polita
T1  - Određivanje aukubina primenom HPLC i HPTLC tehnika u metanolnim ekstraktima vrsta Veronica montana, Veronica beccabunga i Veronica polita
IS  - 33
SP  - 53
EP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2011
ER  - 

@article{
author = "Živković, Jelena and Janković, Teodora and Maksimović, Zoran",
year = "2013",
abstract = "In the present study, methanolic extracts of three Veronica species, namely Veronica montana, Veronica beccabunga and Veronica polita, were analyzed for the total iridoids, total phenylethanoids and total phenolics contents. The results showed that iridoid glycosides are the major class of tested secondary metabolites in selected Veronica species. The highest iridoid content (467.33 mg/g d.w.) was recorded in extract of V. polita, while the richest source of total phenolics and total phenylethanoids was the extract of V. montana (105.24 mg GAE/g d.w. and 16.03 mg acteoside/g d.w., respectively). Additionally, aucubin determination in tested extracts was performed by high-performance liquid chromatography (HPLC) and high-performance thin layer chromatography (HPTLC). The aucubin content in investigated samples determined by HPLC varied between 5.66 in extract of V. beccabunga and 69.96 mg/g d.w. in extract of V. polita. No significant differences were observed between the aucubin content in plant extracts obtained by HPLC and HPTLC techniques. The proposed HPTLC method is simple, rapid and more economical as compared to HPLC method, and thus it may be suitable for routine identification and quantification of aucubin in Veronica species., U ovom radu, primenom spektrofotometrijskih metoda, određen je sadržaj ukupnih fenola, fenilpropanoida i iridoida u metanolnim ekstraktima herbi Veronica montana, V. beccabunga i V. polita. Rezultati spektofotometrijske analize pokazuju da su iridoidni glukozidi dominantna grupa sekundarnih metabolita u odabranim vrstama. Njihov sadržaj bio je najveći u herbi V. polita, dok je V. montana bila najbogatija ukupnim fenolima i ukupnim fenilpropanoidima. Dodatno, u ispitivanim ekstraktima kvantifikovan je aukubin primenom tehnika visoko-efikasne tečne hromatografije (HPLC) i visoko-efikasne tankoslojne hromatografije (HPTLC). Sadržaj aukubina određen primenom HPLC tehnike kretao se od 5,66 u ekstraktu V. beccabunga do 69,96 mg/g suve mase u ekstraktu V. polita. Iz rezultata dobijenih u ovom radu uočava se da nema statistički značajnih razlika između vrednosti za sadržaj aukubina dobijenih primenom HPLC i HPTLC tehnika. Predložena HPTLC metoda kao jednostavnija, ekonomičnija, sa mogućnošću analize više uzoraka istovremeno, može biti pogodna za rutinsku identifikaciju i kvantifikaciju aukubina u Veronica vrstama, kao i sastavni deo protokola za procenu autentičnosti biljnog materijala.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Determination of aucubin by HPLC and HPTLC methods in methanolic extracts of Veronica montana, Veronica beccabunga and Veronica polita, Određivanje aukubina primenom HPLC i HPTLC tehnika u metanolnim ekstraktima vrsta Veronica montana, Veronica beccabunga i Veronica polita",
number = "33",
pages = "53-61",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2011"
}

Živković, J., Janković, T.,& Maksimović, Z.. (2013). Determination of aucubin by HPLC and HPTLC methods in methanolic extracts of Veronica montana, Veronica beccabunga and Veronica polita. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(33), 53-61.
https://hdl.handle.net/21.15107/rcub_farfar_2011

Živković J, Janković T, Maksimović Z. Determination of aucubin by HPLC and HPTLC methods in methanolic extracts of Veronica montana, Veronica beccabunga and Veronica polita. in Lekovite sirovine. 2013;(33):53-61.
https://hdl.handle.net/21.15107/rcub_farfar_2011 .

Živković, Jelena, Janković, Teodora, Maksimović, Zoran, "Determination of aucubin by HPLC and HPTLC methods in methanolic extracts of Veronica montana, Veronica beccabunga and Veronica polita" in Lekovite sirovine, no. 33 (2013):53-61,
https://hdl.handle.net/21.15107/rcub_farfar_2011 .

TY  - JOUR
AU  - Stojković, Dejan
AU  - Živković, Jelena
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ferreira, Isabel C. F. R.
AU  - Janković, Teodora
AU  - Maksimović, Zoran
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1935
AB  - This study was designed to evaluate the antibacterial activity of the Veronica montana L. water extract and its main phenolic compound, protocatechuic acid. The antibacterial activity was determined by microdilution assay against six strains of Gram-positive and Gram-negative bacteria. Listeria monocytogenes was the most sensitive of the tested bacterial species. Antibacterial preserving properties of protocatechuic acid were also evaluated after its incorporation in cream cheese, using L. monocytogenes as commonly cheese contaminant. The compound successfully inhibited L monocytogenes development in cream cheese, at room temperature and in refrigerator (25 degrees C and 4 degrees C, respectively), after 3 days of inoculation. Sensory evaluation was carried out in order to validate the mentioned food system. A possible mode of action of the tested compound towards bacterial cells was assessed and appears to be direct lysis of pathogenic cytoplasmic membrane. Prediction of pharmacokinetic properties was also performed using computational analyzes. The obtained results can serve as an important platform for the development of effective natural preservatives.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system
VL  - 55
SP  - 209
EP  - 213
DO  - 10.1016/j.fct.2013.01.005
ER  - 

@article{
author = "Stojković, Dejan and Živković, Jelena and Soković, Marina and Glamočlija, Jasmina and Ferreira, Isabel C. F. R. and Janković, Teodora and Maksimović, Zoran",
year = "2013",
abstract = "This study was designed to evaluate the antibacterial activity of the Veronica montana L. water extract and its main phenolic compound, protocatechuic acid. The antibacterial activity was determined by microdilution assay against six strains of Gram-positive and Gram-negative bacteria. Listeria monocytogenes was the most sensitive of the tested bacterial species. Antibacterial preserving properties of protocatechuic acid were also evaluated after its incorporation in cream cheese, using L. monocytogenes as commonly cheese contaminant. The compound successfully inhibited L monocytogenes development in cream cheese, at room temperature and in refrigerator (25 degrees C and 4 degrees C, respectively), after 3 days of inoculation. Sensory evaluation was carried out in order to validate the mentioned food system. A possible mode of action of the tested compound towards bacterial cells was assessed and appears to be direct lysis of pathogenic cytoplasmic membrane. Prediction of pharmacokinetic properties was also performed using computational analyzes. The obtained results can serve as an important platform for the development of effective natural preservatives.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system",
volume = "55",
pages = "209-213",
doi = "10.1016/j.fct.2013.01.005"
}

Stojković, D., Živković, J., Soković, M., Glamočlija, J., Ferreira, I. C. F. R., Janković, T.,& Maksimović, Z.. (2013). Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 55, 209-213.
https://doi.org/10.1016/j.fct.2013.01.005

Stojković D, Živković J, Soković M, Glamočlija J, Ferreira ICFR, Janković T, Maksimović Z. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. in Food and Chemical Toxicology. 2013;55:209-213.
doi:10.1016/j.fct.2013.01.005 .

Stojković, Dejan, Živković, Jelena, Soković, Marina, Glamočlija, Jasmina, Ferreira, Isabel C. F. R., Janković, Teodora, Maksimović, Zoran, "Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system" in Food and Chemical Toxicology, 55 (2013):209-213,
https://doi.org/10.1016/j.fct.2013.01.005 . .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Janković, Teodora
AU  - Juranić, Zorica
AU  - Menković, Nebojša
AU  - Stanković, Ivan
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1497
AB  - Total phenolics total anthocyanins mineral content radical scavenging activity and antiproliferative activity against human cancer cell lines were evaluated in fresh pressed juices of five different berries Total phenolic content ranged from 133 0 to 260 3 mg of gallic acid equivalents/100 g of fresh weight for red currant and black currant respectively Bilberry Juice contained the highest amount of total anthocyanins (0 18%) Significant correlation between total phenolics content and radical scavenging activity was observed (r = -0980 p  lt  0 01) All examined juices showed antiproliferative activity in dose-dependent manner with IC50 ranging from 10 2 to 70 5 mu l/ml Black currant juice was the most effective inhibitor of proliferation in all cell lines tested (HeLa Fem X LS 174 MCF-7 and PC-3) Significant correlations of acidity and total anthocyanin content with antiproliferative activity of berry juices on HeLa cells Fem X cells and MCF-7 cells were noticed Berry juices are good sources of some minerals and contribute significantly to daily intake of these micronutrients
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Biological activity and chemical composition of different berry juices
VL  - 125
IS  - 4
SP  - 1412
EP  - 1417
DO  - 10.1016/j.foodchem.2010.10.018
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Šavikin, Katarina and Zdunić, Gordana and Janković, Teodora and Juranić, Zorica and Menković, Nebojša and Stanković, Ivan",
year = "2011",
abstract = "Total phenolics total anthocyanins mineral content radical scavenging activity and antiproliferative activity against human cancer cell lines were evaluated in fresh pressed juices of five different berries Total phenolic content ranged from 133 0 to 260 3 mg of gallic acid equivalents/100 g of fresh weight for red currant and black currant respectively Bilberry Juice contained the highest amount of total anthocyanins (0 18%) Significant correlation between total phenolics content and radical scavenging activity was observed (r = -0980 p  lt  0 01) All examined juices showed antiproliferative activity in dose-dependent manner with IC50 ranging from 10 2 to 70 5 mu l/ml Black currant juice was the most effective inhibitor of proliferation in all cell lines tested (HeLa Fem X LS 174 MCF-7 and PC-3) Significant correlations of acidity and total anthocyanin content with antiproliferative activity of berry juices on HeLa cells Fem X cells and MCF-7 cells were noticed Berry juices are good sources of some minerals and contribute significantly to daily intake of these micronutrients",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Biological activity and chemical composition of different berry juices",
volume = "125",
number = "4",
pages = "1412-1417",
doi = "10.1016/j.foodchem.2010.10.018"
}

Konić-Ristić, A., Šavikin, K., Zdunić, G., Janković, T., Juranić, Z., Menković, N.,& Stanković, I.. (2011). Biological activity and chemical composition of different berry juices. in Food Chemistry
Elsevier Sci Ltd, Oxford., 125(4), 1412-1417.
https://doi.org/10.1016/j.foodchem.2010.10.018

Konić-Ristić A, Šavikin K, Zdunić G, Janković T, Juranić Z, Menković N, Stanković I. Biological activity and chemical composition of different berry juices. in Food Chemistry. 2011;125(4):1412-1417.
doi:10.1016/j.foodchem.2010.10.018 .

Konić-Ristić, Aleksandra, Šavikin, Katarina, Zdunić, Gordana, Janković, Teodora, Juranić, Zorica, Menković, Nebojša, Stanković, Ivan, "Biological activity and chemical composition of different berry juices" in Food Chemistry, 125, no. 4 (2011):1412-1417,
https://doi.org/10.1016/j.foodchem.2010.10.018 . .

TY  - JOUR
AU  - Šavikin-Fodulović, Katarina
AU  - Stojanović, Danilo
AU  - Menković, Nebojša
AU  - Krstić, Dijana
AU  - Janković, Teodora
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/306
AB  - Gentiana dinarica Beck. (Gentianaceae) is a rare plant species growing at carbonate soils in subalpine and alpine regions. Acording to the Flora of Serbia G. dinarica is only distributed in Kosovo. In course of our recent pharmacognostic investigations G. dinarica was found at two localities on the mountain Tara, locality Zvezda (1230 m) and Veliki Kraj (1330 m). Plant material (aerial parts and roots) was collected from June to August 2000-2001. Anatomic and phytochemical analyses were carried out. Preliminary screening of the extracts of the roots and aerial parts of G. dinarica showed the presence of secoiridoids, flavonoids and xanthone compounds. From both extracts three secoiridoids were isolated (swertiamarin, gentiopicrin and sweroside).
AB  - Vrsta Gentiana dinarica Beck. (Gentianaceae) je retka biljna vrsta koja je u Srbiji, prema Flori Srbije, do sada konstatovana samo na Kosovu. U toku terenskih istraživanja, ovu vrstu smo zabeležili na dva lokaliteta na planini Tari i to lokalitet Zvezda (1230 m) i lokalitet Veliki Kraj (1330 m).Specifičnost anatomske građe korena G. dinarica je slabo odrveneo kislem, i tzv. unutarksilemski floem, odnosno grupice floemskih elemenata u centralnom delu sekundarnog drveta.Preliminarno ispitivanje ekstrakata korena i nadzemnog dela G. dinarica pokazao je prisustvo sekoiridoida, flavonoida i ksantona. Od sekoiridoida, izolovani su svercijamarin, genciopikrin i sverozid.
PB  - Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd
T2  - Lekovite sirovine
T1  - Phytochemical and anatomic study of plant species Gentiana dinarica Beck
T1  - Fitohemijska i anatomska analiza vrste Gentiana dinarica Beck., Gentianaceae
IS  - 21
SP  - 31
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_farfar_306
ER  - 

@article{
author = "Šavikin-Fodulović, Katarina and Stojanović, Danilo and Menković, Nebojša and Krstić, Dijana and Janković, Teodora",
year = "2001",
abstract = "Gentiana dinarica Beck. (Gentianaceae) is a rare plant species growing at carbonate soils in subalpine and alpine regions. Acording to the Flora of Serbia G. dinarica is only distributed in Kosovo. In course of our recent pharmacognostic investigations G. dinarica was found at two localities on the mountain Tara, locality Zvezda (1230 m) and Veliki Kraj (1330 m). Plant material (aerial parts and roots) was collected from June to August 2000-2001. Anatomic and phytochemical analyses were carried out. Preliminary screening of the extracts of the roots and aerial parts of G. dinarica showed the presence of secoiridoids, flavonoids and xanthone compounds. From both extracts three secoiridoids were isolated (swertiamarin, gentiopicrin and sweroside)., Vrsta Gentiana dinarica Beck. (Gentianaceae) je retka biljna vrsta koja je u Srbiji, prema Flori Srbije, do sada konstatovana samo na Kosovu. U toku terenskih istraživanja, ovu vrstu smo zabeležili na dva lokaliteta na planini Tari i to lokalitet Zvezda (1230 m) i lokalitet Veliki Kraj (1330 m).Specifičnost anatomske građe korena G. dinarica je slabo odrveneo kislem, i tzv. unutarksilemski floem, odnosno grupice floemskih elemenata u centralnom delu sekundarnog drveta.Preliminarno ispitivanje ekstrakata korena i nadzemnog dela G. dinarica pokazao je prisustvo sekoiridoida, flavonoida i ksantona. Od sekoiridoida, izolovani su svercijamarin, genciopikrin i sverozid.",
publisher = "Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd",
journal = "Lekovite sirovine",
title = "Phytochemical and anatomic study of plant species Gentiana dinarica Beck, Fitohemijska i anatomska analiza vrste Gentiana dinarica Beck., Gentianaceae",
number = "21",
pages = "31-36",
url = "https://hdl.handle.net/21.15107/rcub_farfar_306"
}

Šavikin-Fodulović, K., Stojanović, D., Menković, N., Krstić, D.,& Janković, T.. (2001). Phytochemical and anatomic study of plant species Gentiana dinarica Beck. in Lekovite sirovine
Institut za proučavanje lekovitog bilja Dr Josif Pančić, Beograd.(21), 31-36.
https://hdl.handle.net/21.15107/rcub_farfar_306

Šavikin-Fodulović K, Stojanović D, Menković N, Krstić D, Janković T. Phytochemical and anatomic study of plant species Gentiana dinarica Beck. in Lekovite sirovine. 2001;(21):31-36.
https://hdl.handle.net/21.15107/rcub_farfar_306 .

Šavikin-Fodulović, Katarina, Stojanović, Danilo, Menković, Nebojša, Krstić, Dijana, Janković, Teodora, "Phytochemical and anatomic study of plant species Gentiana dinarica Beck" in Lekovite sirovine, no. 21 (2001):31-36,
https://hdl.handle.net/21.15107/rcub_farfar_306 .