TY  - CONF
AU  - Ivković, Branka
AU  - Soković, Marina
AU  - Marković, Bojan
AU  - Vladimirova, S.
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1195
PB  - Medimond S R L, 40128 Bologna
C3  - Joint Meeting on Medical Chemistry
T1  - Synthesis and Evaluation of Derivatives of Phenylpropiophenone as potential antibacterial and antifungal agents
SP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1195
ER  - 

@conference{
author = "Ivković, Branka and Soković, Marina and Marković, Bojan and Vladimirova, S.",
year = "2009",
publisher = "Medimond S R L, 40128 Bologna",
journal = "Joint Meeting on Medical Chemistry",
title = "Synthesis and Evaluation of Derivatives of Phenylpropiophenone as potential antibacterial and antifungal agents",
pages = "61",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1195"
}

Ivković, B., Soković, M., Marković, B.,& Vladimirova, S.. (2009). Synthesis and Evaluation of Derivatives of Phenylpropiophenone as potential antibacterial and antifungal agents. in Joint Meeting on Medical Chemistry
Medimond S R L, 40128 Bologna., 61.
https://hdl.handle.net/21.15107/rcub_farfar_1195

Ivković B, Soković M, Marković B, Vladimirova S. Synthesis and Evaluation of Derivatives of Phenylpropiophenone as potential antibacterial and antifungal agents. in Joint Meeting on Medical Chemistry. 2009;:61.
https://hdl.handle.net/21.15107/rcub_farfar_1195 .

Ivković, Branka, Soković, Marina, Marković, Bojan, Vladimirova, S., "Synthesis and Evaluation of Derivatives of Phenylpropiophenone as potential antibacterial and antifungal agents" in Joint Meeting on Medical Chemistry (2009):61,
https://hdl.handle.net/21.15107/rcub_farfar_1195 .

TY  - JOUR
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Janković, I.
AU  - Karljiković-Rajić, Katarina
AU  - Vladimirova, S.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1090
AB  - In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Study of valsartan interaction with micelles as a model system for biomembranes
VL  - 65
IS  - 1
SP  - 80
EP  - 84
DO  - 10.1016/j.colsurfb.2008.03.002
ER  - 

@article{
author = "Čudina, Olivera and Brborić, Jasmina and Janković, I. and Karljiković-Rajić, Katarina and Vladimirova, S.",
year = "2008",
abstract = "In this study, the interaction of valsartan (VAL), an angiotensin II receptor antagonist, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on spectroscopic and acid-base properties of VAL was carried out using UV spectrophotometry at physiological conditions (pH 7.4). The binding of VAL to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) = 1.69) proving the great affinity of VAL dianion for the positively charged CTAB micelle surface. To quantify the degree of VAL/CTAB interaction, two constants were calculated by using mathematical models: micelle/water partition coefficient (K-x) and drug/micelle binding constant (K-b). The decrease of K-x with VAL concentration, obtained by using pseudo-phase model, is consistent with an adsorption-like phenomenon. From the dependence of differential absorbance at lambda = 295 nm on CTAB concentration, by using mathematical model that treats the solubilization of VAL dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant (K-b = (2.50 +/- 10.49) x 10(4) M-1) was obtained. Binding constant VAL/CTAB was also calculated using micellar liquid chromatography (MLC).",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Study of valsartan interaction with micelles as a model system for biomembranes",
volume = "65",
number = "1",
pages = "80-84",
doi = "10.1016/j.colsurfb.2008.03.002"
}

Čudina, O., Brborić, J., Janković, I., Karljiković-Rajić, K.,& Vladimirova, S.. (2008). Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces B: Biointerfaces
Elsevier Science BV, Amsterdam., 65(1), 80-84.
https://doi.org/10.1016/j.colsurfb.2008.03.002

Čudina O, Brborić J, Janković I, Karljiković-Rajić K, Vladimirova S. Study of valsartan interaction with micelles as a model system for biomembranes. in Colloids and Surfaces B: Biointerfaces. 2008;65(1):80-84.
doi:10.1016/j.colsurfb.2008.03.002 .

Čudina, Olivera, Brborić, Jasmina, Janković, I., Karljiković-Rajić, Katarina, Vladimirova, S., "Study of valsartan interaction with micelles as a model system for biomembranes" in Colloids and Surfaces B: Biointerfaces, 65, no. 1 (2008):80-84,
https://doi.org/10.1016/j.colsurfb.2008.03.002 . .