TY  - JOUR
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Stojanović, Dušica
AU  - Ibrić, Svetlana
AU  - Uskoković, Petar
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4410
AB  - In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for
semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the
obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by
lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug
kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has
shown good thermal stability, mechanical properties, and prolonged release of IBU following the
Fickian diffusion process.
AB  - Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery
T1  - 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu
VL  - 72
IS  - 6
SP  - 661
EP  - 673
DO  - 10.5937/arhfarm72-40262
ER  - 

@article{
author = "Jovanović, Marija and Petrović, Miloš and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2022",
abstract = "In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for
semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the
obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by
lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug
kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has
shown good thermal stability, mechanical properties, and prolonged release of IBU following the
Fickian diffusion process., Nosač za dostavu ibuprofena (IBU) u koštanom tkivu dobijen je metodom 3D štampe ekstruzijom iz paste uz korišćenje smeše polimera želatina A (GA) i polivinilpirolidona (PVP K30). Dobijeni nosač je umrežen sa 1% rastvorom glutaraldehida (GTA), nakon čega je usledio proces liofilizacije uzoraka. Ispitivana su mehanička i termička svojstva, profili i kinetika oslobađanja ibuprofena iz dobijenih nosača. Umrežen i liofilizovan nosač pokazao je dobru termičku stabilnost i mehanička svojstva, kao i produženo oslobađanje IBU-a koje prati kinetiku po Fikovom zakonu difuzije.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery, 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu",
volume = "72",
number = "6",
pages = "661-673",
doi = "10.5937/arhfarm72-40262"
}

Jovanović, M., Petrović, M., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2022). Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 661-673.
https://doi.org/10.5937/arhfarm72-40262

Jovanović M, Petrović M, Stojanović D, Ibrić S, Uskoković P. Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za farmaciju. 2022;72(6):661-673.
doi:10.5937/arhfarm72-40262 .

Jovanović, Marija, Petrović, Miloš, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery" in Arhiv za farmaciju, 72, no. 6 (2022):661-673,
https://doi.org/10.5937/arhfarm72-40262 . .

TY  - JOUR
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Cvijić, Sandra
AU  - Tomić, Nataša
AU  - Stojanović, Dušica
AU  - Ibrić, Svetlana
AU  - Uskoković, Petar
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4016
AB  - Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.
PB  - MDPI
T2  - Pharmaceutics
T1  - 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction
VL  - 13
IS  - 12
DO  - 10.3390/pharmaceutics13122143
ER  - 

@article{
author = "Jovanović, Marija and Petrović, Miloš and Cvijić, Sandra and Tomić, Nataša and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2021",
abstract = "Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction",
volume = "13",
number = "12",
doi = "10.3390/pharmaceutics13122143"
}

Jovanović, M., Petrović, M., Cvijić, S., Tomić, N., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2021). 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. in Pharmaceutics
MDPI., 13(12).
https://doi.org/10.3390/pharmaceutics13122143

Jovanović M, Petrović M, Cvijić S, Tomić N, Stojanović D, Ibrić S, Uskoković P. 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. in Pharmaceutics. 2021;13(12).
doi:10.3390/pharmaceutics13122143 .

Jovanović, Marija, Petrović, Miloš, Cvijić, Sandra, Tomić, Nataša, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction" in Pharmaceutics, 13, no. 12 (2021),
https://doi.org/10.3390/pharmaceutics13122143 . .