@conference{
author = "Adamov, Ivana and Tenić, Milica and Pešić, Nikola and Medarević, Đorđe and Ivković, Branka and Ibrić, Svetlana",
year = "2022",
abstract = "In recent years, introduction of modern technologies, such as 3D printing, has
opened a new chapter and caused a paradigm shift from manufacturing of large-scale to
small batches of medicines tailored accordingly to the specific needs of patients (1). The aim
of this study was to formulate and fabricate two-layered tablets using digital light processing
(DLP) technique, which utilizes light irradiation to create solid objects from photoreactive
liquid resin in a layer-by-layer manner. Hydrochlorothiazide (HHT, 5%,w/w) and warfarin
sodium (VRN, 5%,w/w) were selected as model drugs, commonly used together in the
treatment of cardiovascular diseases. 3D printing process was initiated with 0.10% of
photoinitiator, at a constant ratio of poly(ethylene glycol)diacrylate and poly(ethylene
glycol) 400, 1:1, with the addition of water (10%,w/w). 3D tablets, with each of the active
substances in a separate layer, 8.00 mm in diameter and 1.50 mm thick, as well as combined
two-layered tablets with HHT and VRN in individual layers, were successfully printed with
Wanhao D8 printer. Dissolution test results showed immediate, but incomplete release of
VRN (81.47 ± 1.47%, after 45 min) from individual layers, while the release of HHT was
prolonged and complete (98.17 ± 3.11%, after 8 h). Significantly slower and incomplete
release of VRN and HHT from combined tablets was observed. The absence of interactions
and the presence of a layered structure were confirmed. DLP technique has a potential to
provide fast fabrication of combined tablets, while further optimization of formulation
factors is necessary in order to achieve complete drug release., Poslednjih godina, uvođenjem savremenih tehnologija, poput 3D štampe, otvorilo se
novo poglavlje u načinu proizvodnje lekova i uslovilo razvoj fundamentalnih promena, pri
čemu serijska proizvodnja velikih šarži pretenduje da bude zamenjena malim serijama
lekova prilagođenih specifičnim potrebama pacijenata (1). Cilj ovog istraživanja bio je da se
formulišu i izrade dvoslojne tablete primenom tehnike digitalne obrade svetlosti (DLP) koja
omogućava dobijanje objekata mehanizmom nanošenja materijala “sloj po sloj” iz tečne
fotopolimerizacione smole pod uticajem svetlosti. Hidrohlortiazid (HHT, 5%, m/m) i
varfarin-natrijum (VRN, 5%, m/m) odabrani su kao model lekovite supstance, koje se obično
primenjuju zajedno u lečenju kardiovaskularnih bolesti. Proces 3D štampanja sproveden je u
prisustvu 0,10% fotoinicijatora, pri konstantnom masenom odnosu poli(etilen
glikol)diakrilata i poli(etilen glikola) 400, 1:1, uz dodatak 10% vode. 3D tablete, sa svakom
od aktivnih supstanci u posebnom sloju, prečnika 8,00 mm i debljine 1,50 mm, kao i
kombinovane dvoslojne tablete sa HHT i VRN u pojedinačnim slojevima, uspešno su
odštampane u Wanhao D8 štampaču. Prilikom ispitivanja brzine rastvaranja lekovite
supstance iz pojedinačnih slojeva, došlo je do trenutnog (81,47 ± 1,47% nakon 45 min), ali
nepotpunog oslobađanja VRN, dok je HHT u potpunosti oslobođen, prateći kinetiku
produženog oslobađanja (98,17 ± 3,11%, nakon 8 h). Zapaženo je znatno sporije i nepotpuno
oslobađanje VRN i HHT iz kombinovanih dvoslojnih tableta, nakon 8 h. Potvrđeno je
odsustvo interakcija i prisustvo slojevite strukture. DLP tehnika ima potencijal da obezbedi
brzu izradu kombinovanih tableta, pri čemu je neophodna dalja optimizacija formulacionih
faktora u cilju postizanja potpunog oslobađanja lekovite supstance.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Application of 3D printing photopolymerization technique in the fabrication of two-layered tablets, Primena fotopolimerizacione tehnike 3D štampe lekova u izradi dvoslojnih tableta",
volume = "72",
number = "4 suplement",
pages = "S410-S411",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4573"
}
