TY  - CONF
AU  - Adamov, Ivana
AU  - Stanojević, Gordana
AU  - Kočović, David
AU  - Mugoša, Snežana
AU  - Grujić, Branka
AU  - Ibrić, Svetlana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5066
AB  - Three-dimensional printing (3DP) is an innovative
additive manufacturing technology in the field of
pharmaceuticals that has the potential to provide small
batches of patient-tailored medicines (Wang et al., 2021).
One of the newest and most advanced 3DP techniques is
selective laser sintering (SLS), a one-step manufacturing
process that uses a laser to selectively sinter powder
particles into layers and create a 3D structure of a solid
dosage form. Depending on the 3D design of the object, the
laser is focused to draw specific patterns on the surface of
the powder. Once the first layer is sintered, a fresh layer of
powder is sprinkled on top so that a new layer can be
sintered (Allahham et al., 2020). The aim of this study was
to formulate and investigate the influence of the model
design on the properties of zolpidem tartrate (ZT) tablets
produced by the SLS 3DP process.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets
VL  - 69
IS  - Suppl 1
SP  - 133
EP  - 134
DO  - 10.33320/maced.pharm.bull.2023.69.03.065
ER  - 

@conference{
author = "Adamov, Ivana and Stanojević, Gordana and Kočović, David and Mugoša, Snežana and Grujić, Branka and Ibrić, Svetlana",
year = "2023",
abstract = "Three-dimensional printing (3DP) is an innovative
additive manufacturing technology in the field of
pharmaceuticals that has the potential to provide small
batches of patient-tailored medicines (Wang et al., 2021).
One of the newest and most advanced 3DP techniques is
selective laser sintering (SLS), a one-step manufacturing
process that uses a laser to selectively sinter powder
particles into layers and create a 3D structure of a solid
dosage form. Depending on the 3D design of the object, the
laser is focused to draw specific patterns on the surface of
the powder. Once the first layer is sintered, a fresh layer of
powder is sprinkled on top so that a new layer can be
sintered (Allahham et al., 2020). The aim of this study was
to formulate and investigate the influence of the model
design on the properties of zolpidem tartrate (ZT) tablets
produced by the SLS 3DP process.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets",
volume = "69",
number = "Suppl 1",
pages = "133-134",
doi = "10.33320/maced.pharm.bull.2023.69.03.065"
}

Adamov, I., Stanojević, G., Kočović, D., Mugoša, S., Grujić, B.,& Ibrić, S.. (2023). Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 133-134.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.065

Adamov I, Stanojević G, Kočović D, Mugoša S, Grujić B, Ibrić S. Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):133-134.
doi:10.33320/maced.pharm.bull.2023.69.03.065 .

Adamov, Ivana, Stanojević, Gordana, Kočović, David, Mugoša, Snežana, Grujić, Branka, Ibrić, Svetlana, "Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):133-134,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.065 . .

TY  - JOUR
AU  - Adamov, Ivana
AU  - Stanojević, Gordana
AU  - Medarević, Đorđe
AU  - Ivković, Branka
AU  - Kočović, David
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4275
AB  - The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.
PB  - Elsevier
T2  - International journal of pharmaceutics
T1  - Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique
VL  - 624
DO  - 10.1016/j.ijpharm.2022.122046
ER  - 

@article{
author = "Adamov, Ivana and Stanojević, Gordana and Medarević, Đorđe and Ivković, Branka and Kočović, David and Mirković, Dušica and Ibrić, Svetlana",
year = "2022",
abstract = "The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.",
publisher = "Elsevier",
journal = "International journal of pharmaceutics",
title = "Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique",
volume = "624",
doi = "10.1016/j.ijpharm.2022.122046"
}

Adamov, I., Stanojević, G., Medarević, Đ., Ivković, B., Kočović, D., Mirković, D.,& Ibrić, S.. (2022). Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique. in International journal of pharmaceutics
Elsevier., 624.
https://doi.org/10.1016/j.ijpharm.2022.122046

Adamov I, Stanojević G, Medarević Đ, Ivković B, Kočović D, Mirković D, Ibrić S. Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique. in International journal of pharmaceutics. 2022;624.
doi:10.1016/j.ijpharm.2022.122046 .

Adamov, Ivana, Stanojević, Gordana, Medarević, Đorđe, Ivković, Branka, Kočović, David, Mirković, Dušica, Ibrić, Svetlana, "Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique" in International journal of pharmaceutics, 624 (2022),
https://doi.org/10.1016/j.ijpharm.2022.122046 . .

TY  - JOUR
AU  - Stanojević, Gordana
AU  - Medarević, Đorđe
AU  - Adamov, Ivana
AU  - Pešić, Nikola
AU  - Kovačević, Jovana
AU  - Ibrić, Svetlana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3771
AB  - Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.
PB  - MDPI
T2  - Molecules (Basel, Switzerland)
T1  - Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading
VL  - 26
IS  - 1
DO  - 10.3390/molecules26010111
ER  - 

@article{
author = "Stanojević, Gordana and Medarević, Đorđe and Adamov, Ivana and Pešić, Nikola and Kovačević, Jovana and Ibrić, Svetlana",
year = "2020",
abstract = "Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.",
publisher = "MDPI",
journal = "Molecules (Basel, Switzerland)",
title = "Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading",
volume = "26",
number = "1",
doi = "10.3390/molecules26010111"
}

Stanojević, G., Medarević, Đ., Adamov, I., Pešić, N., Kovačević, J.,& Ibrić, S.. (2020). Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading. in Molecules (Basel, Switzerland)
MDPI., 26(1).
https://doi.org/10.3390/molecules26010111

Stanojević G, Medarević Đ, Adamov I, Pešić N, Kovačević J, Ibrić S. Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading. in Molecules (Basel, Switzerland). 2020;26(1).
doi:10.3390/molecules26010111 .

Stanojević, Gordana, Medarević, Đorđe, Adamov, Ivana, Pešić, Nikola, Kovačević, Jovana, Ibrić, Svetlana, "Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading" in Molecules (Basel, Switzerland), 26, no. 1 (2020),
https://doi.org/10.3390/molecules26010111 . .