TY  - JOUR
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Cvijić, Sandra
AU  - Tomić, Nataša
AU  - Stojanović, Dušica
AU  - Ibrić, Svetlana
AU  - Uskoković, Petar
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4016
AB  - Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.
PB  - MDPI
T2  - Pharmaceutics
T1  - 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction
VL  - 13
IS  - 12
DO  - 10.3390/pharmaceutics13122143
ER  - 

@article{
author = "Jovanović, Marija and Petrović, Miloš and Cvijić, Sandra and Tomić, Nataša and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2021",
abstract = "Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction",
volume = "13",
number = "12",
doi = "10.3390/pharmaceutics13122143"
}

Jovanović, M., Petrović, M., Cvijić, S., Tomić, N., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2021). 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. in Pharmaceutics
MDPI., 13(12).
https://doi.org/10.3390/pharmaceutics13122143

Jovanović M, Petrović M, Cvijić S, Tomić N, Stojanović D, Ibrić S, Uskoković P. 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. in Pharmaceutics. 2021;13(12).
doi:10.3390/pharmaceutics13122143 .

Jovanović, Marija, Petrović, Miloš, Cvijić, Sandra, Tomić, Nataša, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction" in Pharmaceutics, 13, no. 12 (2021),
https://doi.org/10.3390/pharmaceutics13122143 . .

TY  - JOUR
AU  - Jovanović, Marija
AU  - Tomić, Nataša
AU  - Cvijić, Sandra
AU  - Stojanović, Dušica
AU  - Ibrić, Svetlana
AU  - Uskoković, Petar
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3804
AB  - This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films.  Two types of gelatin are used:  Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness.  A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.
PB  - MDPI AG
T2  - Pharmaceutics
T1  - Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties
VL  - 13
IS  - 2
SP  - 1
EP  - 19
DO  - 10.3390/pharmaceutics13020273
ER  - 

@article{
author = "Jovanović, Marija and Tomić, Nataša and Cvijić, Sandra and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2021",
abstract = "This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films.  Two types of gelatin are used:  Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness.  A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.",
publisher = "MDPI AG",
journal = "Pharmaceutics",
title = "Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties",
volume = "13",
number = "2",
pages = "1-19",
doi = "10.3390/pharmaceutics13020273"
}

Jovanović, M., Tomić, N., Cvijić, S., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2021). Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties. in Pharmaceutics
MDPI AG., 13(2), 1-19.
https://doi.org/10.3390/pharmaceutics13020273

Jovanović M, Tomić N, Cvijić S, Stojanović D, Ibrić S, Uskoković P. Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties. in Pharmaceutics. 2021;13(2):1-19.
doi:10.3390/pharmaceutics13020273 .

Jovanović, Marija, Tomić, Nataša, Cvijić, Sandra, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties" in Pharmaceutics, 13, no. 2 (2021):1-19,
https://doi.org/10.3390/pharmaceutics13020273 . .