TY  - CONF
AU  - Pešić, Nikola
AU  - Krkobabić, Mirjana
AU  - Adamov, Ivana
AU  - Ivković, Branka
AU  - Ibrić, Svetlana
AU  - Mirković, Dušica
AU  - Medarević, Đorđe
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5069
AB  - The adjustment of the dose according to the individual
needs of the patient is a unique advantage of 3D printing
technology, which is of particular importance for the
pediatric and geriatric population, due to the diverse needs
and characteristics of these groups of patients (Kotta et al.,
2018).
Selective laser sintering (SLS) is one of the newest 3D
printing techniques that uses powder materials, where the
powder particles are connected under the influence of laser
beams. The main disadvantage of SLS 3D printing is the
high process temperature, which can lead to the
degradation of active substances. On the other hand, this
technique has many advantages, such as high resolution,
the possibility of powder recycling and the absence of pre-
processing (Fina et al., 2018; Thakkar et al., 2021).
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - 3D printing of carvedilol oral dosage forms using selective laser sintering technique
VL  - 69
IS  - Suppl 1
SP  - 169
EP  - 170
DO  - 10.33320/maced.pharm.bull.2023.69.03.083
ER  - 

@conference{
author = "Pešić, Nikola and Krkobabić, Mirjana and Adamov, Ivana and Ivković, Branka and Ibrić, Svetlana and Mirković, Dušica and Medarević, Đorđe",
year = "2023",
abstract = "The adjustment of the dose according to the individual
needs of the patient is a unique advantage of 3D printing
technology, which is of particular importance for the
pediatric and geriatric population, due to the diverse needs
and characteristics of these groups of patients (Kotta et al.,
2018).
Selective laser sintering (SLS) is one of the newest 3D
printing techniques that uses powder materials, where the
powder particles are connected under the influence of laser
beams. The main disadvantage of SLS 3D printing is the
high process temperature, which can lead to the
degradation of active substances. On the other hand, this
technique has many advantages, such as high resolution,
the possibility of powder recycling and the absence of pre-
processing (Fina et al., 2018; Thakkar et al., 2021).",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "3D printing of carvedilol oral dosage forms using selective laser sintering technique",
volume = "69",
number = "Suppl 1",
pages = "169-170",
doi = "10.33320/maced.pharm.bull.2023.69.03.083"
}

Pešić, N., Krkobabić, M., Adamov, I., Ivković, B., Ibrić, S., Mirković, D.,& Medarević, Đ.. (2023). 3D printing of carvedilol oral dosage forms using selective laser sintering technique. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 169-170.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.083

Pešić N, Krkobabić M, Adamov I, Ivković B, Ibrić S, Mirković D, Medarević Đ. 3D printing of carvedilol oral dosage forms using selective laser sintering technique. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):169-170.
doi:10.33320/maced.pharm.bull.2023.69.03.083 .

Pešić, Nikola, Krkobabić, Mirjana, Adamov, Ivana, Ivković, Branka, Ibrić, Svetlana, Mirković, Dušica, Medarević, Đorđe, "3D printing of carvedilol oral dosage forms using selective laser sintering technique" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):169-170,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.083 . .

TY  - CONF
AU  - Krstevska, Aleksandra
AU  - Nedelkov, Ivana
AU  - Petrović, Maša
AU  - Ibrić, Svetlana
AU  - Mirković, Dušica
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5053
AB  - Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound
VL  - 69
IS  - Suppl 1
SP  - 127
EP  - 128
DO  - 10.33320/maced.pharm.bull.2023.69.03.062
ER  - 

@conference{
author = "Krstevska, Aleksandra and Nedelkov, Ivana and Petrović, Maša and Ibrić, Svetlana and Mirković, Dušica and Cvijić, Sandra",
year = "2023",
abstract = "Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound",
volume = "69",
number = "Suppl 1",
pages = "127-128",
doi = "10.33320/maced.pharm.bull.2023.69.03.062"
}

Krstevska, A., Nedelkov, I., Petrović, M., Ibrić, S., Mirković, D.,& Cvijić, S.. (2023). In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 127-128.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.062

Krstevska A, Nedelkov I, Petrović M, Ibrić S, Mirković D, Cvijić S. In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):127-128.
doi:10.33320/maced.pharm.bull.2023.69.03.062 .

Krstevska, Aleksandra, Nedelkov, Ivana, Petrović, Maša, Ibrić, Svetlana, Mirković, Dušica, Cvijić, Sandra, "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):127-128,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.062 . .

TY  - JOUR
AU  - Adamov, Ivana
AU  - Stanojević, Gordana
AU  - Medarević, Đorđe
AU  - Ivković, Branka
AU  - Kočović, David
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4275
AB  - The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.
PB  - Elsevier
T2  - International journal of pharmaceutics
T1  - Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique
VL  - 624
DO  - 10.1016/j.ijpharm.2022.122046
ER  - 

@article{
author = "Adamov, Ivana and Stanojević, Gordana and Medarević, Đorđe and Ivković, Branka and Kočović, David and Mirković, Dušica and Ibrić, Svetlana",
year = "2022",
abstract = "The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.",
publisher = "Elsevier",
journal = "International journal of pharmaceutics",
title = "Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique",
volume = "624",
doi = "10.1016/j.ijpharm.2022.122046"
}

Adamov, I., Stanojević, G., Medarević, Đ., Ivković, B., Kočović, D., Mirković, D.,& Ibrić, S.. (2022). Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique. in International journal of pharmaceutics
Elsevier., 624.
https://doi.org/10.1016/j.ijpharm.2022.122046

Adamov I, Stanojević G, Medarević Đ, Ivković B, Kočović D, Mirković D, Ibrić S. Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique. in International journal of pharmaceutics. 2022;624.
doi:10.1016/j.ijpharm.2022.122046 .

Adamov, Ivana, Stanojević, Gordana, Medarević, Đorđe, Ivković, Branka, Kočović, David, Mirković, Dušica, Ibrić, Svetlana, "Formulation and characterization of immediate-release oral dosage forms with zolpidem tartrate fabricated by digital light processing (DLP) 3D printing technique" in International journal of pharmaceutics, 624 (2022),
https://doi.org/10.1016/j.ijpharm.2022.122046 . .

TY  - JOUR
AU  - Cvijić, Sandra
AU  - Mirković, Dušica
AU  - Krajišnik, Danina
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4260
AB  - The treatment of respiratory infections in children requires special attention, since the
paediatric population has rather specific characteristics and consists of heterogenous subgroups.
In this context, the choice of a suitable drug dosage form is of particular importance, depending
on the active substance properties, along with the age and general condition of a paediatric patient.
Тhe most commonly used pharmaceutical products for respiratory infections in children include
oral, parenteral and inhalation dosage forms, although a large number of drugs are not available
in a suitable dosage form and/or strength for paediatric age, leading to the frequent use of
unauthorized drugs (i.e., unlicensed use). Other important issues that should be considered when
choosing the appropriate paediatric dosage form and/or compounding procedure are related to the
careful considerations of the pharmaceutical product composition (safety of excipients) and the
choice of administration/dosing device in relation to a child’s age.
This paper provides an overview of paediatric dosage forms used in the treatment of
respiratory infections in children, their benefits and limitations. The review includes examples of
various pharmaceutical products, along with the considerations regarding administration/dosing
devices. Specific characteristics of paediatric populations affecting the decision on the choice of
age-appropriate paediatric formulation are also addressed.
AB  - Terapija respiratornih infekcija kod dece zahteva posebnu pažnju, jer ovu populaciju čini specifična i izuzetno heterogena grupa pacijenata. Veoma je važno odabrati odgovarajući farmaceutski oblik leka, u skladu sa karakteristikama aktivne supstance, kao i stanjem i uzrastom deteta. U praksi se, u terapiji respiratornih infekcija kod dece, najviše koriste preparati za oralnu primenu, za parenteralnu primenu i za inhalaciju. Međutim, veliki broj lekova nije dostupan u odgovarajućem farmaceutskom obliku i/ili jačini za pedijatrijski uzrast, usled čega je česta neodobrena upotreba lekova. Prilikom izbora/izrade preparata za decu potrebno je pažljivo razmotriti i sastav preparata (bezbednost pomoćnih supstanci), kao i izbor aplikatora, u skladu sa uzrastom deteta. U ovom radu je dat prikaz farmaceutskih oblika lekova koji se koriste u terapiji respiratornih infekcija kod dece, njihovih prednosti i izvesnih nedostataka. Navedeni su različiti primeri farmaceutskih preparata, uz poseban osvrt na izbor aplikatora za primenu/doziranje lekova. Takođe, diskutovane su specifičnosti pedijatrijske populacije koje utiču na izbor odgovarajuće formulacije leka prilagođene uzrastu deteta.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips
T1  - Stavovi i saveti vezani za izbor farmaceutskih oblika lekova za lečenje respiratornih infekcija kod dece
VL  - 72
IS  - 3
SP  - 353
EP  - 372
DO  - 10.5937/arhfarm72-37643
ER  - 

@article{
author = "Cvijić, Sandra and Mirković, Dušica and Krajišnik, Danina",
year = "2022",
abstract = "The treatment of respiratory infections in children requires special attention, since the
paediatric population has rather specific characteristics and consists of heterogenous subgroups.
In this context, the choice of a suitable drug dosage form is of particular importance, depending
on the active substance properties, along with the age and general condition of a paediatric patient.
Тhe most commonly used pharmaceutical products for respiratory infections in children include
oral, parenteral and inhalation dosage forms, although a large number of drugs are not available
in a suitable dosage form and/or strength for paediatric age, leading to the frequent use of
unauthorized drugs (i.e., unlicensed use). Other important issues that should be considered when
choosing the appropriate paediatric dosage form and/or compounding procedure are related to the
careful considerations of the pharmaceutical product composition (safety of excipients) and the
choice of administration/dosing device in relation to a child’s age.
This paper provides an overview of paediatric dosage forms used in the treatment of
respiratory infections in children, their benefits and limitations. The review includes examples of
various pharmaceutical products, along with the considerations regarding administration/dosing
devices. Specific characteristics of paediatric populations affecting the decision on the choice of
age-appropriate paediatric formulation are also addressed., Terapija respiratornih infekcija kod dece zahteva posebnu pažnju, jer ovu populaciju čini specifična i izuzetno heterogena grupa pacijenata. Veoma je važno odabrati odgovarajući farmaceutski oblik leka, u skladu sa karakteristikama aktivne supstance, kao i stanjem i uzrastom deteta. U praksi se, u terapiji respiratornih infekcija kod dece, najviše koriste preparati za oralnu primenu, za parenteralnu primenu i za inhalaciju. Međutim, veliki broj lekova nije dostupan u odgovarajućem farmaceutskom obliku i/ili jačini za pedijatrijski uzrast, usled čega je česta neodobrena upotreba lekova. Prilikom izbora/izrade preparata za decu potrebno je pažljivo razmotriti i sastav preparata (bezbednost pomoćnih supstanci), kao i izbor aplikatora, u skladu sa uzrastom deteta. U ovom radu je dat prikaz farmaceutskih oblika lekova koji se koriste u terapiji respiratornih infekcija kod dece, njihovih prednosti i izvesnih nedostataka. Navedeni su različiti primeri farmaceutskih preparata, uz poseban osvrt na izbor aplikatora za primenu/doziranje lekova. Takođe, diskutovane su specifičnosti pedijatrijske populacije koje utiču na izbor odgovarajuće formulacije leka prilagođene uzrastu deteta.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips, Stavovi i saveti vezani za izbor farmaceutskih oblika lekova za lečenje respiratornih infekcija kod dece",
volume = "72",
number = "3",
pages = "353-372",
doi = "10.5937/arhfarm72-37643"
}

Cvijić, S., Mirković, D.,& Krajišnik, D.. (2022). How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 72(3), 353-372.
https://doi.org/10.5937/arhfarm72-37643

Cvijić S, Mirković D, Krajišnik D. How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips. in Arhiv za farmaciju. 2022;72(3):353-372.
doi:10.5937/arhfarm72-37643 .

Cvijić, Sandra, Mirković, Dušica, Krajišnik, Danina, "How to choose an appropriate drug dosage form for the treatment of respiratory infections in children: Facts and tips" in Arhiv za farmaciju, 72, no. 3 (2022):353-372,
https://doi.org/10.5937/arhfarm72-37643 . .

TY  - JOUR
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3663
AB  - Primena nanoemulzija (NE) za parenteralnu is-hranu predstavlja izuzetno značajno dostignuće koje je obe-ležilo medicinu i farmaciju dvadesetog veka. Tokom godina, tehnologija izrade NE i smeša za totalnu parenteralnu ishra-nu  (TPN)  stalno  se  usavršavala.  Ovaj  rad  predstavlja  nasta-vak prethodnog istraživanja i odnosi se na problematiku na-noemulzija (NE) koncentracije 20%, izrađenih u laboratorij-skim  uslovima.  Osnovni  akcenat  stavljen  je  na  mogućnost detektovanja  eventualnog  prisustva  većih  kapi  ili  njihovih  aglomerata  koji  bi  mogli  da  izazovu  fatalne  efekte.  Pored  toga,  izvršena  je  i  procena  kvaliteta  smeše  za  TPN  sa  NE.  Rezultati  su  upoređeni  sa  rezultatima  dobijenim  praćenjem smeše  za  TPN  izrađene  od  fabrički  proizvedene  emulzije  (Lipofundin MCT/LCT 20%®). Metode. Primenom meto-de laserske difrakcije, praćenjem  u periodu od 30 dana, do-bijeni su rezultati koji se odnose na širinu raspodele veličina kapi   NE,   izraženu   kao   volumenski   prečnik.   Fizičko-hemijske karakteristike smeša za TPN određivane su tokom 72 sata i obuhvatale su: merenje srednjeg prečnika kapi, vo-lumenskog  prečnika,  distribucije  veličina  kapi  (PDI)  i  ζ-potencijala, kao i pH-vrednosti. Rezultati. Dobijeni rezulta-ti bili su u skladu sa literaturnim podacima o kvalitetu paren-teralnih  NE  (vrednosti  volumenskih  prečnika  kretale  su  se  između 50 i 490 nm). Tokom 72 h praćenja, TPN su ostale stabilne  (i  smeša  za  TPN  sa  NE  izrađenom  u  laboratoriji,  kao  i  TPN  sa  fabrički  izrađenom  NE).
PB  - Belgrade : Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions
T1  - Ispitivanje kratkotrajne stabilnosti nanoemulzija za parenteralnu ishranu izrađenih u laboratorijskim uslovima
VL  - 77
IS  - 7
SP  - 688
EP  - 696
DO  - 10.2298/VSP180115140M
DO  - 2-s2.0-85090469547
ER  - 

@article{
author = "Mirković, Dušica and Ibrić, Svetlana",
year = "2020",
abstract = "Primena nanoemulzija (NE) za parenteralnu is-hranu predstavlja izuzetno značajno dostignuće koje je obe-ležilo medicinu i farmaciju dvadesetog veka. Tokom godina, tehnologija izrade NE i smeša za totalnu parenteralnu ishra-nu  (TPN)  stalno  se  usavršavala.  Ovaj  rad  predstavlja  nasta-vak prethodnog istraživanja i odnosi se na problematiku na-noemulzija (NE) koncentracije 20%, izrađenih u laboratorij-skim  uslovima.  Osnovni  akcenat  stavljen  je  na  mogućnost detektovanja  eventualnog  prisustva  većih  kapi  ili  njihovih  aglomerata  koji  bi  mogli  da  izazovu  fatalne  efekte.  Pored  toga,  izvršena  je  i  procena  kvaliteta  smeše  za  TPN  sa  NE.  Rezultati  su  upoređeni  sa  rezultatima  dobijenim  praćenjem smeše  za  TPN  izrađene  od  fabrički  proizvedene  emulzije  (Lipofundin MCT/LCT 20%®). Metode. Primenom meto-de laserske difrakcije, praćenjem  u periodu od 30 dana, do-bijeni su rezultati koji se odnose na širinu raspodele veličina kapi   NE,   izraženu   kao   volumenski   prečnik.   Fizičko-hemijske karakteristike smeša za TPN određivane su tokom 72 sata i obuhvatale su: merenje srednjeg prečnika kapi, vo-lumenskog  prečnika,  distribucije  veličina  kapi  (PDI)  i  ζ-potencijala, kao i pH-vrednosti. Rezultati. Dobijeni rezulta-ti bili su u skladu sa literaturnim podacima o kvalitetu paren-teralnih  NE  (vrednosti  volumenskih  prečnika  kretale  su  se  između 50 i 490 nm). Tokom 72 h praćenja, TPN su ostale stabilne  (i  smeša  za  TPN  sa  NE  izrađenom  u  laboratoriji,  kao  i  TPN  sa  fabrički  izrađenom  NE).",
publisher = "Belgrade : Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions, Ispitivanje kratkotrajne stabilnosti nanoemulzija za parenteralnu ishranu izrađenih u laboratorijskim uslovima",
volume = "77",
number = "7",
pages = "688-696",
doi = "10.2298/VSP180115140M, 2-s2.0-85090469547"
}

Mirković, D.,& Ibrić, S.. (2020). Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions. in Vojnosanitetski pregled
Belgrade : Military Medical Academy, INI., 77(7), 688-696.
https://doi.org/10.2298/VSP180115140M

Mirković D, Ibrić S. Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions. in Vojnosanitetski pregled. 2020;77(7):688-696.
doi:10.2298/VSP180115140M .

Mirković, Dušica, Ibrić, Svetlana, "Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions" in Vojnosanitetski pregled, 77, no. 7 (2020):688-696,
https://doi.org/10.2298/VSP180115140M . .

TY  - JOUR
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
AU  - Balanc, Bojana
AU  - Knez, Željko
AU  - Bugarski, Branko
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2996
AB  - The aim of this study was to develop, characterize and evaluate concentrated nanoemulsions (20%) for parenteral nutrition. Those systems were developed by the high-pressure homogenization method. Optimal conditions for the nanoemulsion production were identified using 2(4-1) fractional factorial design. The characterization of physicochemical parameters was carried out immediately after the nanoemulsion production, and after 10 and 30 days. The biological control was conducted 30 days after their preparation as well. The oil phase contained the combination of the soybean (SO) and fish oil (FO) as well as the fish oil and medium-chain triglycerides (MCT), while the aqueous phase was composed of water for injections. The egg yolk phospholipids (EP) were used as surfactants alone, or in combination with Poloxamer 188 (PI). The obtained results were in accordance with the literature date e.i. quality requirements for parenteral emulsions (the droplet diameter  lt = 500 nm, PDI  lt = 0.25, absolute value of zeta-potential >= 25 mV, pH-value in the range of 6-9). It was shown that the combination of two surfactants (the egg yolk phospholipids that provides the electrostatic stabilization and Poloxamer 188-steric stabilizer) used as emulsifiers ensures the optimal quality of the obtained nanoemulsions for parenteral nutrition.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions
VL  - 39
SP  - 341
EP  - 347
DO  - 10.1016/j.jddst.2017.04.004
ER  - 

@article{
author = "Mirković, Dušica and Ibrić, Svetlana and Balanc, Bojana and Knez, Željko and Bugarski, Branko",
year = "2017",
abstract = "The aim of this study was to develop, characterize and evaluate concentrated nanoemulsions (20%) for parenteral nutrition. Those systems were developed by the high-pressure homogenization method. Optimal conditions for the nanoemulsion production were identified using 2(4-1) fractional factorial design. The characterization of physicochemical parameters was carried out immediately after the nanoemulsion production, and after 10 and 30 days. The biological control was conducted 30 days after their preparation as well. The oil phase contained the combination of the soybean (SO) and fish oil (FO) as well as the fish oil and medium-chain triglycerides (MCT), while the aqueous phase was composed of water for injections. The egg yolk phospholipids (EP) were used as surfactants alone, or in combination with Poloxamer 188 (PI). The obtained results were in accordance with the literature date e.i. quality requirements for parenteral emulsions (the droplet diameter  lt = 500 nm, PDI  lt = 0.25, absolute value of zeta-potential >= 25 mV, pH-value in the range of 6-9). It was shown that the combination of two surfactants (the egg yolk phospholipids that provides the electrostatic stabilization and Poloxamer 188-steric stabilizer) used as emulsifiers ensures the optimal quality of the obtained nanoemulsions for parenteral nutrition.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions",
volume = "39",
pages = "341-347",
doi = "10.1016/j.jddst.2017.04.004"
}

Mirković, D., Ibrić, S., Balanc, B., Knez, Ž.,& Bugarski, B.. (2017). Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 39, 341-347.
https://doi.org/10.1016/j.jddst.2017.04.004

Mirković D, Ibrić S, Balanc B, Knez Ž, Bugarski B. Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions. in Journal of Drug Delivery Science and Technology. 2017;39:341-347.
doi:10.1016/j.jddst.2017.04.004 .

Mirković, Dušica, Ibrić, Svetlana, Balanc, Bojana, Knez, Željko, Bugarski, Branko, "Evaluation of the impact of critical quality attributes and critical process parameters on quality and stability of parenteral nutrition nanoemulsions" in Journal of Drug Delivery Science and Technology, 39 (2017):341-347,
https://doi.org/10.1016/j.jddst.2017.04.004 . .

TY  - JOUR
AU  - Mirković, Dušica
AU  - Ibrić, Svetlana
AU  - Antunović, Mirjana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2052
AB  - Background/Aim. Parenteral nutrition as a specific aspect of providing nutritients still remains a permanent topic of both theoretical and experimental research. Total parenteral nutrition (TPN) admixtures have complex contents making difficult to maintain their stability. The most critical parameter is the diameter of a lipid droplet, i.e. droplet size distribution. It is recommended that droplet size should not be more than 5 􀆬m and that the presence of greater droplets should not exceed the value of 0.05%. Lipid droplets size is affected particularly by electrolyte addition, especially polyvalent cations. There is a danger of the added electrolytes interaction with lipid droplets which leads to their aggregation and negative effects upon the admixtures stability. The aim of this study was to assess the effect of added electrolyte and lipid phase quantity on the admixture stability. Methods. Electrolytes were added to the studied admixture of a defined basic formulation contents in accordance with recommendations from the literature. Droplets size measurements were performed using the method of laser diffraction with a laser particles analyzer. Effects of independent variables were calculated and evaluated using commercial software. Na+, K+, Ca2+ and Mg2+ concentrations, as well as the quantity of fat phase were chosen as studied factors, i.e. independent variables. The system response, or dependent variable was the median of droplets size. Each of the factors was varied at two levels, higher (+1) and lower (-1), according to the 25-2 fractional factorial design. Results. The study suggested the presence of relative uniformity of the results of all the measurements regardless of the quantity of added electrolytes and lipid phase. It was shown that undoubtedly there is the influence of 2-valent cations (calcium and magnesium) upon lipid droplets size, which is in a direct correlation with theoretical assumption. Conclusion. Within a 72-hour testing period there was no significant increase in droplet size, i.e. the studied admixtures remained stable considering droplet size median as the criterion of stability.
AB  - Uvod/Cilj. Parenteralna ishrana, kao specifičan vid nadoknade hranljivih materija, i dalje predstavlja stalnu temu teorijskog i eksperimentalnog izučavanja. Složeni sastav smeše za totalnu parenteralnu ishranu (TPI) otežava održanje njihove stabilnosti. Najkritičniji parameter je dijametar lipidnih kapi, odnosno raspodela veličina kapi. Postoji preporuka da veličina kapi ne bi trebalo da prelazi 5 μm i da zastupljenost većih kapi ne prelazi vrednost od 0,05%. Na veličinu lipidnih kapi poseban uticaj ima dodavanje elektrolita, naročito viševalentnih katjona. Postoji opasnost da dodati elektroliti interreaguju sa lipidnim kapima, što dovodi do njihovog spajanja i ima negativan uticaj na stabilnost smeša. Cilj ovog rada bio je da se istraži kako dodati elektroliti i količina lipidne faze utiču na stabilnost ovih smeša. Metode. Ispitivanoj smeši sa definisanim sastavom osnovne formulacije izrađenoj u bolničkoj apoteci, dodavani su elektroliti na osnovu preporuka iz literature. Merenje veličine kapi vršeno je metodom laserske difrakcije pomoću laserskog analizatora čestica. Uticaj nezavisno promenljivih je procenjen i izračunat primenom komercijalnog softvera. Kao nezavisno promenljive, u svojstvu ispitivanih faktora izabrani su koncentracije Na+, K+, Ca2+ i Mg2+, kao i količina masne faze. Odgovor sistema, ili zavisno promenljiva veličina, bila je medijana veličine kapi. Svaki od faktora variran je na dva nivoa, gornji (+1) i donji (-1), odnosno primenjen je 25-2 frakcioni faktorijalni dizajn. Rezultati. Istraživanje je pokazalo da nezavisno od količine dodatih elektrolita i količine lipidne faze postoji relativna ujednačenost rezultata za sva merenja. Analiza pojedinačnih faktora ukazuje na nesumnjiv uticaj dvovalentnih katjona (kalcijuma i magnezijuma) na veličinu lipidnih kapi, što je u direktnoj korelaciji sa teoretskim postavkama. Zaključak: Tokom ispitivanog 72-časovnog perioda nije bilo značajnog povećanja veličine kapi, odnosno ispitivana smeša ostala je stabilna sa stanovišta medijane veličine kapi kao kriterijuma stabilnosti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design
T1  - Analiza kvaliteta smeša za totalnu parenteralnu ishranu primenom delimičnog faktorijalnog dizajna
VL  - 70
IS  - 4
SP  - 374
EP  - 379
DO  - 10.2298/VSP1304374M
ER  - 

@article{
author = "Mirković, Dušica and Ibrić, Svetlana and Antunović, Mirjana",
year = "2013",
abstract = "Background/Aim. Parenteral nutrition as a specific aspect of providing nutritients still remains a permanent topic of both theoretical and experimental research. Total parenteral nutrition (TPN) admixtures have complex contents making difficult to maintain their stability. The most critical parameter is the diameter of a lipid droplet, i.e. droplet size distribution. It is recommended that droplet size should not be more than 5 􀆬m and that the presence of greater droplets should not exceed the value of 0.05%. Lipid droplets size is affected particularly by electrolyte addition, especially polyvalent cations. There is a danger of the added electrolytes interaction with lipid droplets which leads to their aggregation and negative effects upon the admixtures stability. The aim of this study was to assess the effect of added electrolyte and lipid phase quantity on the admixture stability. Methods. Electrolytes were added to the studied admixture of a defined basic formulation contents in accordance with recommendations from the literature. Droplets size measurements were performed using the method of laser diffraction with a laser particles analyzer. Effects of independent variables were calculated and evaluated using commercial software. Na+, K+, Ca2+ and Mg2+ concentrations, as well as the quantity of fat phase were chosen as studied factors, i.e. independent variables. The system response, or dependent variable was the median of droplets size. Each of the factors was varied at two levels, higher (+1) and lower (-1), according to the 25-2 fractional factorial design. Results. The study suggested the presence of relative uniformity of the results of all the measurements regardless of the quantity of added electrolytes and lipid phase. It was shown that undoubtedly there is the influence of 2-valent cations (calcium and magnesium) upon lipid droplets size, which is in a direct correlation with theoretical assumption. Conclusion. Within a 72-hour testing period there was no significant increase in droplet size, i.e. the studied admixtures remained stable considering droplet size median as the criterion of stability., Uvod/Cilj. Parenteralna ishrana, kao specifičan vid nadoknade hranljivih materija, i dalje predstavlja stalnu temu teorijskog i eksperimentalnog izučavanja. Složeni sastav smeše za totalnu parenteralnu ishranu (TPI) otežava održanje njihove stabilnosti. Najkritičniji parameter je dijametar lipidnih kapi, odnosno raspodela veličina kapi. Postoji preporuka da veličina kapi ne bi trebalo da prelazi 5 μm i da zastupljenost većih kapi ne prelazi vrednost od 0,05%. Na veličinu lipidnih kapi poseban uticaj ima dodavanje elektrolita, naročito viševalentnih katjona. Postoji opasnost da dodati elektroliti interreaguju sa lipidnim kapima, što dovodi do njihovog spajanja i ima negativan uticaj na stabilnost smeša. Cilj ovog rada bio je da se istraži kako dodati elektroliti i količina lipidne faze utiču na stabilnost ovih smeša. Metode. Ispitivanoj smeši sa definisanim sastavom osnovne formulacije izrađenoj u bolničkoj apoteci, dodavani su elektroliti na osnovu preporuka iz literature. Merenje veličine kapi vršeno je metodom laserske difrakcije pomoću laserskog analizatora čestica. Uticaj nezavisno promenljivih je procenjen i izračunat primenom komercijalnog softvera. Kao nezavisno promenljive, u svojstvu ispitivanih faktora izabrani su koncentracije Na+, K+, Ca2+ i Mg2+, kao i količina masne faze. Odgovor sistema, ili zavisno promenljiva veličina, bila je medijana veličine kapi. Svaki od faktora variran je na dva nivoa, gornji (+1) i donji (-1), odnosno primenjen je 25-2 frakcioni faktorijalni dizajn. Rezultati. Istraživanje je pokazalo da nezavisno od količine dodatih elektrolita i količine lipidne faze postoji relativna ujednačenost rezultata za sva merenja. Analiza pojedinačnih faktora ukazuje na nesumnjiv uticaj dvovalentnih katjona (kalcijuma i magnezijuma) na veličinu lipidnih kapi, što je u direktnoj korelaciji sa teoretskim postavkama. Zaključak: Tokom ispitivanog 72-časovnog perioda nije bilo značajnog povećanja veličine kapi, odnosno ispitivana smeša ostala je stabilna sa stanovišta medijane veličine kapi kao kriterijuma stabilnosti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design, Analiza kvaliteta smeša za totalnu parenteralnu ishranu primenom delimičnog faktorijalnog dizajna",
volume = "70",
number = "4",
pages = "374-379",
doi = "10.2298/VSP1304374M"
}

Mirković, D., Ibrić, S.,& Antunović, M.. (2013). Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 374-379.
https://doi.org/10.2298/VSP1304374M

Mirković D, Ibrić S, Antunović M. Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design. in Vojnosanitetski pregled. 2013;70(4):374-379.
doi:10.2298/VSP1304374M .

Mirković, Dušica, Ibrić, Svetlana, Antunović, Mirjana, "Quality assessment of total parenteral nutrition admixtures by the use of fractional factorial design" in Vojnosanitetski pregled, 70, no. 4 (2013):374-379,
https://doi.org/10.2298/VSP1304374M . .