TY  - JOUR
AU  - Krstevska, Aleksandra
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4420
AB  - In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to its application in various research topics and model validation was conducted by text mining tools. Orange 3.32.0, an open-source data mining program was used for text mining. PubMed was used for data retrieval, and the collected articles were analyzed by several widgets. A total of 2699 articles related to PBPK modeling met the predefined criteria. The number of publications per year has been rising steadily. Regarding the application areas, the results revealed that 26% of the publications described the use of PBPK modeling in early drug development, risk assessment and toxicity assessment, followed by absorption/formulation modeling (25%), prediction of drug-disease interactions (20%), drug-drug interactions (DDIs) (17%) and pediatric drug development (12%). Furthermore, the analysis showed that only 12% of the publications mentioned model validation, of which 51% referred to literature-based validation and 26% to experimentally validated models. The obtained results present a valuable review of the state-of-the-art regarding PBPK modeling applications in drug discovery and development and related fields.
PB  - MDPI
T2  - Pharmaceutics
T1  - In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools
VL  - 15
IS  - 1
DO  - 10.3390/pharmaceutics15010107
ER  - 

@article{
author = "Krstevska, Aleksandra and Đuriš, Jelena and Ibrić, Svetlana and Cvijić, Sandra",
year = "2023",
abstract = "In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to its application in various research topics and model validation was conducted by text mining tools. Orange 3.32.0, an open-source data mining program was used for text mining. PubMed was used for data retrieval, and the collected articles were analyzed by several widgets. A total of 2699 articles related to PBPK modeling met the predefined criteria. The number of publications per year has been rising steadily. Regarding the application areas, the results revealed that 26% of the publications described the use of PBPK modeling in early drug development, risk assessment and toxicity assessment, followed by absorption/formulation modeling (25%), prediction of drug-disease interactions (20%), drug-drug interactions (DDIs) (17%) and pediatric drug development (12%). Furthermore, the analysis showed that only 12% of the publications mentioned model validation, of which 51% referred to literature-based validation and 26% to experimentally validated models. The obtained results present a valuable review of the state-of-the-art regarding PBPK modeling applications in drug discovery and development and related fields.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools",
volume = "15",
number = "1",
doi = "10.3390/pharmaceutics15010107"
}

Krstevska, A., Đuriš, J., Ibrić, S.,& Cvijić, S.. (2023). In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools. in Pharmaceutics
MDPI., 15(1).
https://doi.org/10.3390/pharmaceutics15010107

Krstevska A, Đuriš J, Ibrić S, Cvijić S. In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools. in Pharmaceutics. 2023;15(1).
doi:10.3390/pharmaceutics15010107 .

Krstevska, Aleksandra, Đuriš, Jelena, Ibrić, Svetlana, Cvijić, Sandra, "In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools" in Pharmaceutics, 15, no. 1 (2023),
https://doi.org/10.3390/pharmaceutics15010107 . .

TY  - CONF
AU  - Krstevska, Aleksandra
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5068
AB  - Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability to mechanistically explain how drug properties,
product quality attributes and physiological factors
influence the in vivo drug performance. To better specify
the application field of these models and highlight the link
between in vitro dissolution and drug’s in vivo behavior, a
novel term, physiologically based biopharmaceutics
modeling (PBBM), was recently introduced.
The versatility of application of these models is
perceived through the growth in the number of scientific
publications that include the use of PBPK/PBBM
(Krstevska et al, 2022). In the present study, the use of
PBPK/PBBM across the publications from the past decade
was analyzed, with the focus on the application of these
models in pharmaceutical/formulation development.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development
VL  - 69
IS  - Suppl 1
SP  - 145
EP  - 146
DO  - 10.33320/maced.pharm.bull.2023.69.03.071
ER  - 

@conference{
author = "Krstevska, Aleksandra and Đuriš, Jelena and Ibrić, Svetlana and Cvijić, Sandra",
year = "2023",
abstract = "Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability to mechanistically explain how drug properties,
product quality attributes and physiological factors
influence the in vivo drug performance. To better specify
the application field of these models and highlight the link
between in vitro dissolution and drug’s in vivo behavior, a
novel term, physiologically based biopharmaceutics
modeling (PBBM), was recently introduced.
The versatility of application of these models is
perceived through the growth in the number of scientific
publications that include the use of PBPK/PBBM
(Krstevska et al, 2022). In the present study, the use of
PBPK/PBBM across the publications from the past decade
was analyzed, with the focus on the application of these
models in pharmaceutical/formulation development.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development",
volume = "69",
number = "Suppl 1",
pages = "145-146",
doi = "10.33320/maced.pharm.bull.2023.69.03.071"
}

Krstevska, A., Đuriš, J., Ibrić, S.,& Cvijić, S.. (2023). A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 145-146.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.071

Krstevska A, Đuriš J, Ibrić S, Cvijić S. A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):145-146.
doi:10.33320/maced.pharm.bull.2023.69.03.071 .

Krstevska, Aleksandra, Đuriš, Jelena, Ibrić, Svetlana, Cvijić, Sandra, "A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):145-146,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.071 . .

TY  - CONF
AU  - Krstevska, Aleksandra
AU  - Nedelkov, Ivana
AU  - Petrović, Maša
AU  - Ibrić, Svetlana
AU  - Mirković, Dušica
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5053
AB  - Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound
VL  - 69
IS  - Suppl 1
SP  - 127
EP  - 128
DO  - 10.33320/maced.pharm.bull.2023.69.03.062
ER  - 

@conference{
author = "Krstevska, Aleksandra and Nedelkov, Ivana and Petrović, Maša and Ibrić, Svetlana and Mirković, Dušica and Cvijić, Sandra",
year = "2023",
abstract = "Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a weak base
may get into a supersaturated state, which is
thermodynamically unstable and tends to precipitate
(Makitalo, 2019). Consequently, precipitation in the
gastrointestinal (GI) tract may significantly limit oral
bioavailability (BA) of poorly soluble, weak bases.
Several in vitro and in silico tools are available for
assessing the precipitation kinetics of weakly basic
compounds (Kou et al., 2018). The dynamic nature of
physiologically based in silico models and their ability to
treat drug dissolution and precipitation as variables
affecting concomitant drug bioperformance make in silico
models a powerful tool to assess the impact of these
variables on drug absorption.
The aim of this work was to in silico evaluate the
influence of possible variations in the values of GI
physiological parameters on the potential precipitation and
absorption of a weakly basic, poorly soluble and highly
permeable compound. ...",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound",
volume = "69",
number = "Suppl 1",
pages = "127-128",
doi = "10.33320/maced.pharm.bull.2023.69.03.062"
}

Krstevska, A., Nedelkov, I., Petrović, M., Ibrić, S., Mirković, D.,& Cvijić, S.. (2023). In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 127-128.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.062

Krstevska A, Nedelkov I, Petrović M, Ibrić S, Mirković D, Cvijić S. In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):127-128.
doi:10.33320/maced.pharm.bull.2023.69.03.062 .

Krstevska, Aleksandra, Nedelkov, Ivana, Petrović, Maša, Ibrić, Svetlana, Mirković, Dušica, Cvijić, Sandra, "In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):127-128,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.062 . .