TY  - CONF
AU  - Glišić, Teodora
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5337
AB  - Raspadanje tableta u gastrointestinalnim tečnostima i posledično rastvaranje lekovite supstance u korelaciji su sa kvašenjem i prodiranjem vode u tabletu, što je najčešće povezano sa fizičko-hemijskim osobinama ekscipijenasa. Pokazalo se da tečna faza prisutna u tečno-čvrstim (TČ) sistemima poboljšava njihovo kvašenje i posledično povećava bioraspoloživost. Cilj ovog rada bio je da se ispita sposobnost kvašenja TČ sistema pripremljenih sa četiri porozna nosača, korišćenjem različitih metoda ispitivanja. ..
AB  - Tablet disintegration in gastrointestinal fluids and subsequent drug dissolution correlate with
wettability and water penetration into the tablet which are usually related to the physicochemical
properties of excipients. Liquid phase present within Liquisolid (LS) system was shown to
improve wettability and consequently increase bioavailability. The aim of this study was to
examine the wetting properties of LS systems prepared with four porous carriers, by using
different testing methods. ...
PB  - Farmaceutska komora Crne Gore
PB  - Univerzitet Crne Gore, Medicinski fakultet, studijski program-farmacija
C3  - 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka
T1  - Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima
T1  - An investigation into the wetting properties of liquisolid systems with different carriers
VL  - PP-30
SP  - 140
EP  - 141
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5337
ER  - 

@conference{
author = "Glišić, Teodora and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2023",
abstract = "Raspadanje tableta u gastrointestinalnim tečnostima i posledično rastvaranje lekovite supstance u korelaciji su sa kvašenjem i prodiranjem vode u tabletu, što je najčešće povezano sa fizičko-hemijskim osobinama ekscipijenasa. Pokazalo se da tečna faza prisutna u tečno-čvrstim (TČ) sistemima poboljšava njihovo kvašenje i posledično povećava bioraspoloživost. Cilj ovog rada bio je da se ispita sposobnost kvašenja TČ sistema pripremljenih sa četiri porozna nosača, korišćenjem različitih metoda ispitivanja. .., Tablet disintegration in gastrointestinal fluids and subsequent drug dissolution correlate with
wettability and water penetration into the tablet which are usually related to the physicochemical
properties of excipients. Liquid phase present within Liquisolid (LS) system was shown to
improve wettability and consequently increase bioavailability. The aim of this study was to
examine the wetting properties of LS systems prepared with four porous carriers, by using
different testing methods. ...",
publisher = "Farmaceutska komora Crne Gore, Univerzitet Crne Gore, Medicinski fakultet, studijski program-farmacija",
journal = "4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka",
title = "Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima, An investigation into the wetting properties of liquisolid systems with different carriers",
volume = "PP-30",
pages = "140-141",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5337"
}

Glišić, T., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2023). Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima. in 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka
Farmaceutska komora Crne Gore., PP-30, 140-141.
https://hdl.handle.net/21.15107/rcub_farfar_5337

Glišić T, Vasiljević I, Parojčić J, Aleksić I. Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima. in 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka. 2023;PP-30:140-141.
https://hdl.handle.net/21.15107/rcub_farfar_5337 .

Glišić, Teodora, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "Ispitivanje sposobnosti kvašenja tečno-čvrstih sistema sa različitim nosačima" in 4. kongres farmaceuta Crne Gore sa međunarodnim učešćem, 11-14. maj 2023. Budva, Bečići, Crna Gora, Zbornik sažetaka, PP-30 (2023):140-141,
https://hdl.handle.net/21.15107/rcub_farfar_5337 .

TY  - CONF
AU  - Adamov, Ivana
AU  - Glišić, Teodora
AU  - Medarević, Đorđe
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5331
AB  - 3D štampa lekova, kao aditivna tehnologija, predstavlja jednostavnu i ekonomski prihvatljivu
alternativu konvencionalnim metodama, pružajući mogućnost dobijanja inovativnih farmaceutskih
oblika i prilagođavanje terapije individualnim potrebama pacijenata (1). Cilj istraživanja bio je da se
formulišu i izrade mini tablete desloratadinа (DSL) primenom 3D tehnike digitalne obrade svetlosti
(engl. Digital light processing, DLP) mehanizmom nanošenja materijala “sloj po sloj”. Mini tablete DSL
(10%, m/m) odabrane su kao farmaceutski oblik leka koji je pogodan za primenu u pedijatrijskoj
populaciji, pre svega sa aspekta fleksibilnosti doziranja. Pripremljena je formulacija sa 1%
fotoinicijatora i 10% vode, dok su polietilenglikol-diakrilat i polietilenglikol 400 bili prisutni u
masenom odnosu 1:1. Kreirani 3D modeli (4,00 × 3,00 mm) uspešno su odštampani primenom
WanhaoD8 štampača. Dobijene su žuto-narandžaste mini tablete uniformnog oblika, debljine i mase
(4,16 ± 0,06 × 2,24 ± 0,04 mm; 42,61 ± 1,15 mg). Nepotpuna ekstrakcija DSL iz unakrsno umreženog
polimernog matriksa rezultovala je relativno niskim sadržajem lekovite supstance u mini tabletama
u odnosu na teorijski sadržaj (72,14 ± 1,04%) (2). Prilikom ispitivanja brzine rastvaranja, nakon 45
min oslobođeno je 50,29 ± 0,14% DSL u 0,1M hlorovodoničnoj kiselini, kao medijumu, uz postizanje
platoa nakon 4 sata (81,19 ± 0,63%). Rezultati DSC analize pokazali su da je došlo do amorfizacije
lekovite supstance, dok je posmatranjem poprečnih preseka odštampanih mini tableta pod
polarizacionim svetlosnim mikroskopom uočeno prisustvo slojevite strukture. DLP tehnika 3D
štampe lekova ima potencijal da obezbedi brzu izradu mini tableta odgovarajućih fizičko-hemijskih
karakteristika, uz mogućnost postizanja modifikovanog oslobađanja lekovite supstance.
AB  - 3D printing as an additive technology represents a simple and economically acceptable
alternative to conventional methods and offers the possibility of obtaining innovative dosage forms
and individualizing therapy according to the specific needs of patients. (1). The aim of the research
was to formulate and manufacture desloratadine mini-tablets (DSL) using digital light processing
(DLP) 3D technique based on a successive layering mechanism. Mini-tablets of DSL (10%,w/w) were
selected as a dosage form suitable for the pediatric population, particularly because of its flexible
dosing. The formulation was prepared with 1% photoinitiator and 10% water, while poly(ethylene
glycol) diacrylate and poly(ethylene glycol) 400 were present in a mass ratio of 1:1. The created 3D
models (4.00×3.00 mm) were successfully printed using WanhaoD8 printer. Yellow-orange mini-
tablets with uniform shape, thickness and mass (4.16±0.06×2.24±0.04 mm; 42.61±1.15 mg) were
produced. Incomplete extraction of DSL from the cross-linked polymer matrix resulted in a relatively
low content of the drug in the mini-tablets compared to the theoretical content (72.14±1.04%) (2).
The dissolution test showed that 50.29±0.14% of DSL was released after 45 minutes in 0.1M
hydrochloric acid medium and reached a plateau after 4 hours (81.19±0.63%). The results of DSC
analysis showed amorphisation of the drug, while observation of the cross-sections of printed mini-
tablets under a polarizing microscope indicated the presence of a layered structure. The DLP
technique has the potential to ensure the rapid production of mini-tablets with suitable
physicochemical properties and to enable modified release of the drug.
PB  - Savez farmaceutskih udruženja Srbije
C3  - Arhiv za farmaciju
T1  - Formulacija i karakterizacija mini tableta desloratadina dobijenih  fotopolimerizacionom tehnikom 3D štampe lekova
T1  - Formulation and characterization of desloratadine mini-tablets obtained by photopolimerization 3D printing technique
VL  - 73
IS  - Suppl. 4
SP  - S59
EP  - S60
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5331
ER  - 

@conference{
author = "Adamov, Ivana and Glišić, Teodora and Medarević, Đorđe and Aleksić, Ivana and Ibrić, Svetlana",
year = "2023",
abstract = "3D štampa lekova, kao aditivna tehnologija, predstavlja jednostavnu i ekonomski prihvatljivu
alternativu konvencionalnim metodama, pružajući mogućnost dobijanja inovativnih farmaceutskih
oblika i prilagođavanje terapije individualnim potrebama pacijenata (1). Cilj istraživanja bio je da se
formulišu i izrade mini tablete desloratadinа (DSL) primenom 3D tehnike digitalne obrade svetlosti
(engl. Digital light processing, DLP) mehanizmom nanošenja materijala “sloj po sloj”. Mini tablete DSL
(10%, m/m) odabrane su kao farmaceutski oblik leka koji je pogodan za primenu u pedijatrijskoj
populaciji, pre svega sa aspekta fleksibilnosti doziranja. Pripremljena je formulacija sa 1%
fotoinicijatora i 10% vode, dok su polietilenglikol-diakrilat i polietilenglikol 400 bili prisutni u
masenom odnosu 1:1. Kreirani 3D modeli (4,00 × 3,00 mm) uspešno su odštampani primenom
WanhaoD8 štampača. Dobijene su žuto-narandžaste mini tablete uniformnog oblika, debljine i mase
(4,16 ± 0,06 × 2,24 ± 0,04 mm; 42,61 ± 1,15 mg). Nepotpuna ekstrakcija DSL iz unakrsno umreženog
polimernog matriksa rezultovala je relativno niskim sadržajem lekovite supstance u mini tabletama
u odnosu na teorijski sadržaj (72,14 ± 1,04%) (2). Prilikom ispitivanja brzine rastvaranja, nakon 45
min oslobođeno je 50,29 ± 0,14% DSL u 0,1M hlorovodoničnoj kiselini, kao medijumu, uz postizanje
platoa nakon 4 sata (81,19 ± 0,63%). Rezultati DSC analize pokazali su da je došlo do amorfizacije
lekovite supstance, dok je posmatranjem poprečnih preseka odštampanih mini tableta pod
polarizacionim svetlosnim mikroskopom uočeno prisustvo slojevite strukture. DLP tehnika 3D
štampe lekova ima potencijal da obezbedi brzu izradu mini tableta odgovarajućih fizičko-hemijskih
karakteristika, uz mogućnost postizanja modifikovanog oslobađanja lekovite supstance., 3D printing as an additive technology represents a simple and economically acceptable
alternative to conventional methods and offers the possibility of obtaining innovative dosage forms
and individualizing therapy according to the specific needs of patients. (1). The aim of the research
was to formulate and manufacture desloratadine mini-tablets (DSL) using digital light processing
(DLP) 3D technique based on a successive layering mechanism. Mini-tablets of DSL (10%,w/w) were
selected as a dosage form suitable for the pediatric population, particularly because of its flexible
dosing. The formulation was prepared with 1% photoinitiator and 10% water, while poly(ethylene
glycol) diacrylate and poly(ethylene glycol) 400 were present in a mass ratio of 1:1. The created 3D
models (4.00×3.00 mm) were successfully printed using WanhaoD8 printer. Yellow-orange mini-
tablets with uniform shape, thickness and mass (4.16±0.06×2.24±0.04 mm; 42.61±1.15 mg) were
produced. Incomplete extraction of DSL from the cross-linked polymer matrix resulted in a relatively
low content of the drug in the mini-tablets compared to the theoretical content (72.14±1.04%) (2).
The dissolution test showed that 50.29±0.14% of DSL was released after 45 minutes in 0.1M
hydrochloric acid medium and reached a plateau after 4 hours (81.19±0.63%). The results of DSC
analysis showed amorphisation of the drug, while observation of the cross-sections of printed mini-
tablets under a polarizing microscope indicated the presence of a layered structure. The DLP
technique has the potential to ensure the rapid production of mini-tablets with suitable
physicochemical properties and to enable modified release of the drug.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Formulacija i karakterizacija mini tableta desloratadina dobijenih  fotopolimerizacionom tehnikom 3D štampe lekova, Formulation and characterization of desloratadine mini-tablets obtained by photopolimerization 3D printing technique",
volume = "73",
number = "Suppl. 4",
pages = "S59-S60",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5331"
}

Adamov, I., Glišić, T., Medarević, Đ., Aleksić, I.,& Ibrić, S.. (2023). Formulacija i karakterizacija mini tableta desloratadina dobijenih  fotopolimerizacionom tehnikom 3D štampe lekova. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije., 73(Suppl. 4), S59-S60.
https://hdl.handle.net/21.15107/rcub_farfar_5331

Adamov I, Glišić T, Medarević Đ, Aleksić I, Ibrić S. Formulacija i karakterizacija mini tableta desloratadina dobijenih  fotopolimerizacionom tehnikom 3D štampe lekova. in Arhiv za farmaciju. 2023;73(Suppl. 4):S59-S60.
https://hdl.handle.net/21.15107/rcub_farfar_5331 .

Adamov, Ivana, Glišić, Teodora, Medarević, Đorđe, Aleksić, Ivana, Ibrić, Svetlana, "Formulacija i karakterizacija mini tableta desloratadina dobijenih  fotopolimerizacionom tehnikom 3D štampe lekova" in Arhiv za farmaciju, 73, no. Suppl. 4 (2023):S59-S60,
https://hdl.handle.net/21.15107/rcub_farfar_5331 .

TY  - CONF
AU  - Aleksić, Ivana
AU  - Ćirin-Varađan, Slobodanka
AU  - Glišić, Teodora
AU  - Petrović, Nađa
AU  - Đuriš, Jelena
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5067
AB  - Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression is particularly challenging when high API
loading is required. The use of co-processed excipients can
result in a robust directly compressible formulation, while
melt granulation has emerged as an environmentally
friendly co-processing method that can result in highly
functional co-processed excipients (Ćirin-Varađan et al,
2022).
The aim of the present study was to investigate the
suitability of lactose co-processed with glyceryl
palmitostearate for the preparation of a directly
compressible formulation of ibuprofen, a challenging high-
dose API. The influence of initial particle size of glyceryl
palmitostearate, ibuprofen content and compression
parameters on compaction behavior of tableting mixtures
was investigated.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations
VL  - 69
IS  - Suppl 1
SP  - 139
EP  - 140
DO  - 10.33320/maced.pharm.bull.2023.69.03.068
ER  - 

@conference{
author = "Aleksić, Ivana and Ćirin-Varađan, Slobodanka and Glišić, Teodora and Petrović, Nađa and Đuriš, Jelena and Parojčić, Jelena",
year = "2023",
abstract = "Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression is particularly challenging when high API
loading is required. The use of co-processed excipients can
result in a robust directly compressible formulation, while
melt granulation has emerged as an environmentally
friendly co-processing method that can result in highly
functional co-processed excipients (Ćirin-Varađan et al,
2022).
The aim of the present study was to investigate the
suitability of lactose co-processed with glyceryl
palmitostearate for the preparation of a directly
compressible formulation of ibuprofen, a challenging high-
dose API. The influence of initial particle size of glyceryl
palmitostearate, ibuprofen content and compression
parameters on compaction behavior of tableting mixtures
was investigated.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations",
volume = "69",
number = "Suppl 1",
pages = "139-140",
doi = "10.33320/maced.pharm.bull.2023.69.03.068"
}

Aleksić, I., Ćirin-Varađan, S., Glišić, T., Petrović, N., Đuriš, J.,& Parojčić, J.. (2023). From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 139-140.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.068

Aleksić I, Ćirin-Varađan S, Glišić T, Petrović N, Đuriš J, Parojčić J. From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):139-140.
doi:10.33320/maced.pharm.bull.2023.69.03.068 .

Aleksić, Ivana, Ćirin-Varađan, Slobodanka, Glišić, Teodora, Petrović, Nađa, Đuriš, Jelena, Parojčić, Jelena, "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):139-140,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.068 . .

TY  - JOUR
AU  - Glišić, Teodora
AU  - Đuriš, Jelena
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4581
AB  - The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.
PB  - MDPI
T2  - Pharmaceutics
T1  - Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers
VL  - 15
IS  - 3
SP  - 741
EP  - 761
DO  - 10.3390/pharmaceutics15030741
ER  - 

@article{
author = "Glišić, Teodora and Đuriš, Jelena and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2023",
abstract = "The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers",
volume = "15",
number = "3",
pages = "741-761",
doi = "10.3390/pharmaceutics15030741"
}

Glišić, T., Đuriš, J., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2023). Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics
MDPI., 15(3), 741-761.
https://doi.org/10.3390/pharmaceutics15030741

Glišić T, Đuriš J, Vasiljević I, Parojčić J, Aleksić I. Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics. 2023;15(3):741-761.
doi:10.3390/pharmaceutics15030741 .

Glišić, Teodora, Đuriš, Jelena, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers" in Pharmaceutics, 15, no. 3 (2023):741-761,
https://doi.org/10.3390/pharmaceutics15030741 . .

TY  - CONF
AU  - Glišić, Teodora
AU  - German Ilić, Ilija
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4750
AB  - 1. INTRODUCTION
Maintaining good compaction properties of
liquisolid systems (LSS) is particularly
challenging in the case of high-dose drugs [1].
High amount of liquid phase within LSS,
required to dissolve/suspend higher amount of
drug substance, while necessary for
improvement of bioavailability, can cause
difficulties during the tableting process,
resulting in low tablet hardness or even inability
of admixtures to be directly compressed. This
has led to the development of new highly porous
carriers, specifically designed for LSS, that can
adsorb/absorb very high amount of liquid phase.
The aim of this study was to investigate the
compaction properties of LSS, prepared with
three types of novel silica-based mesoporous
carriers, using dynamic compaction analysis as
a tool, with the focus on compressibility,
compactibility and tabletability of these systems
[2].
2. MATERIALS AND METHODS
2.1. Materials
Amorphous magnesium aluminometasilicate
(Neusilin® US2, Fuji Chemical Industry Co,
Ltd., Japan) and two types of amorphous
mesoporous silicon dioxide (Syloid® XDP 3050
and Syloid® XDP 3150, Grace GmbH,
Germany) were used as carriers. Colloidal
silicon dioxide (Aerosil 200, Evonik Industries
AG, Germany) was used as coating material and
polyethylene glycol 400 (PEG 400, Fagron,
Netherlands) was used as liquid phase.
2.2. Liquisolid Admixture Preparation
LS admixtures (Table 1) were prepared using
Mycrolab fluid bed processor (OYSTAR
Hüttlin, Germany), with the operating
temperature of 30°C, inlet air flow rate of 20
m3/h, and liquid feed rate of 12 g/min.
Table 1. Composition of prepared LS
admixtures
Liquisolid
admixturesa Rb Liquid
load
PEG
400 (%)
S1 10 0.7 38.9
S2 30 0.7 40.4
S3 10 0.6 35.3
S4 30 0.6 36.7
N1 10 1.1 49.8
N2 30 1.2 54.7
a type of carrier used: S1, S2 - Syloid® XDP
3050, S3, S4 - Syloid® XDP 3150, N1, N2 -
Neusilin® US2; bcarrier to coating material ratio
2.3. Powder density
LS admixtures’ true densities were determined
by helium pycnometer (AccuPyc 1330,
Micromeritics, GA) while bulk and tapped
densities were measured using a graduated
cylinder and a volumeter (STAV 2003, J.
Engelsmann AG, Germany).
2.4. Powder morphology
The morphology of LS particles was examined
using a scanning electron microscope (SEM,
Supra 35VP, Carl Zeiss, Germany).
2.5. Dynamic compaction analysis
Dynamic compaction analysis was performed
on an instrumented tablet press (GTP D series,
Gamlen Tableting Ltd, UK). 6 mm flat faced
punches were used at a compaction speed of 60
mm/min, with compression load ranging from
250 to 500 kg, with a 50 kg increment.
3. RESULTS AND DISCUSSION
3.1. Compressibility of LS admixtures
Regardless of the compaction pressure applied
and differences in liquid load, very high values
of solid fraction were observed in LS compacts
with Neusilin® US2 (0.90-0.94). On the other
hand, LS compacts with both Syloid® XDP
carriers exhibited lower relative density (0.59-
0.89) that was affected by changes in the
applied compaction pressure. Compressibility
profiles suggest that carrier particle size and the
amount of coating material used, had an effect
on relative density. An increase in the amount
of coating material used had a negative impact
on compressibility and lower values of solid
fraction were achieved.
3.2. Compactibility of LS admixtures
Admixtures N1 and N2 could be considered as
having good compactibility [3]. Compacts with
Neusilin® US2 achieved higher tensile strength
values compared to compacts with Syloid®
XDP, even at low compaction pressures.
Particle geometry and shape (Fig. 1) can affect
the way particles interact during tableting and
therefore may affect their mechanical
characteristics. Differences in particle size
could be a reason for lower values of solid
fraction and tensile strength observed in
compacts prepared with Syloid® XDP 3150
compared to compacts with Syloid® XDP 3050
as carrier.
Figure 1. SEM micrographies of LS particles:
admixture N1 (left) and S1 (right)
3.3. Tabletability of LS admixtures
Despite the significantly higher liquid load,
better tabletability was observed in LSS with
Neusilin® US2 as carrier with tensile strength
ranging from 1,68 to 2,55 and 1,61 to 2,11 for
formulations N1 and N2, respectively.
Although relatively similar values of tensile
strength were achieved, tabletability profiles
indicate that there are differences in compaction
behavior between formulations N1 and N2.
Higher values of tensile strength observed at the
same compression pressure indicate better
tabletability of LS admixtures with Syloid®
XDP 3050 compared to those with Syloid®
XDP 3150 as carrier. Interestingly,
formulations with Syloid® XDP 3050 had
higher liquid load which implies that this
formulation factor had lesser influence on
tabletability compared to the properties of the
carrier itself (such as particle size and specific
surface area). The lowest tabletability was
observed in LS admixtures S3 and S4 with
compact tensile strength lower than 1 MPa at all
but highest compaction pressure applied.
4. CONCLUSION
Out of the three investigated carriers, Neusilin®
US2 showed the best compaction properties
despite its high liquid load. LS admixtures with
this carrier exhibited the highest values of
tensile strength and solid fraction at relatively
low compression pressures. Pronounced
differences have been noticed between the two
Syloid carriers, which indicates the effect of
carrier particle size on compaction properties of
LS admixtures.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - Comparative compression characterization of liquisolid systems prepared with mesoporous carriers
SP  - 180
EP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4750
ER  - 

@conference{
author = "Glišić, Teodora and German Ilić, Ilija and Parojčić, Jelena and Aleksić, Ivana",
year = "2022",
abstract = "1. INTRODUCTION
Maintaining good compaction properties of
liquisolid systems (LSS) is particularly
challenging in the case of high-dose drugs [1].
High amount of liquid phase within LSS,
required to dissolve/suspend higher amount of
drug substance, while necessary for
improvement of bioavailability, can cause
difficulties during the tableting process,
resulting in low tablet hardness or even inability
of admixtures to be directly compressed. This
has led to the development of new highly porous
carriers, specifically designed for LSS, that can
adsorb/absorb very high amount of liquid phase.
The aim of this study was to investigate the
compaction properties of LSS, prepared with
three types of novel silica-based mesoporous
carriers, using dynamic compaction analysis as
a tool, with the focus on compressibility,
compactibility and tabletability of these systems
[2].
2. MATERIALS AND METHODS
2.1. Materials
Amorphous magnesium aluminometasilicate
(Neusilin® US2, Fuji Chemical Industry Co,
Ltd., Japan) and two types of amorphous
mesoporous silicon dioxide (Syloid® XDP 3050
and Syloid® XDP 3150, Grace GmbH,
Germany) were used as carriers. Colloidal
silicon dioxide (Aerosil 200, Evonik Industries
AG, Germany) was used as coating material and
polyethylene glycol 400 (PEG 400, Fagron,
Netherlands) was used as liquid phase.
2.2. Liquisolid Admixture Preparation
LS admixtures (Table 1) were prepared using
Mycrolab fluid bed processor (OYSTAR
Hüttlin, Germany), with the operating
temperature of 30°C, inlet air flow rate of 20
m3/h, and liquid feed rate of 12 g/min.
Table 1. Composition of prepared LS
admixtures
Liquisolid
admixturesa Rb Liquid
load
PEG
400 (%)
S1 10 0.7 38.9
S2 30 0.7 40.4
S3 10 0.6 35.3
S4 30 0.6 36.7
N1 10 1.1 49.8
N2 30 1.2 54.7
a type of carrier used: S1, S2 - Syloid® XDP
3050, S3, S4 - Syloid® XDP 3150, N1, N2 -
Neusilin® US2; bcarrier to coating material ratio
2.3. Powder density
LS admixtures’ true densities were determined
by helium pycnometer (AccuPyc 1330,
Micromeritics, GA) while bulk and tapped
densities were measured using a graduated
cylinder and a volumeter (STAV 2003, J.
Engelsmann AG, Germany).
2.4. Powder morphology
The morphology of LS particles was examined
using a scanning electron microscope (SEM,
Supra 35VP, Carl Zeiss, Germany).
2.5. Dynamic compaction analysis
Dynamic compaction analysis was performed
on an instrumented tablet press (GTP D series,
Gamlen Tableting Ltd, UK). 6 mm flat faced
punches were used at a compaction speed of 60
mm/min, with compression load ranging from
250 to 500 kg, with a 50 kg increment.
3. RESULTS AND DISCUSSION
3.1. Compressibility of LS admixtures
Regardless of the compaction pressure applied
and differences in liquid load, very high values
of solid fraction were observed in LS compacts
with Neusilin® US2 (0.90-0.94). On the other
hand, LS compacts with both Syloid® XDP
carriers exhibited lower relative density (0.59-
0.89) that was affected by changes in the
applied compaction pressure. Compressibility
profiles suggest that carrier particle size and the
amount of coating material used, had an effect
on relative density. An increase in the amount
of coating material used had a negative impact
on compressibility and lower values of solid
fraction were achieved.
3.2. Compactibility of LS admixtures
Admixtures N1 and N2 could be considered as
having good compactibility [3]. Compacts with
Neusilin® US2 achieved higher tensile strength
values compared to compacts with Syloid®
XDP, even at low compaction pressures.
Particle geometry and shape (Fig. 1) can affect
the way particles interact during tableting and
therefore may affect their mechanical
characteristics. Differences in particle size
could be a reason for lower values of solid
fraction and tensile strength observed in
compacts prepared with Syloid® XDP 3150
compared to compacts with Syloid® XDP 3050
as carrier.
Figure 1. SEM micrographies of LS particles:
admixture N1 (left) and S1 (right)
3.3. Tabletability of LS admixtures
Despite the significantly higher liquid load,
better tabletability was observed in LSS with
Neusilin® US2 as carrier with tensile strength
ranging from 1,68 to 2,55 and 1,61 to 2,11 for
formulations N1 and N2, respectively.
Although relatively similar values of tensile
strength were achieved, tabletability profiles
indicate that there are differences in compaction
behavior between formulations N1 and N2.
Higher values of tensile strength observed at the
same compression pressure indicate better
tabletability of LS admixtures with Syloid®
XDP 3050 compared to those with Syloid®
XDP 3150 as carrier. Interestingly,
formulations with Syloid® XDP 3050 had
higher liquid load which implies that this
formulation factor had lesser influence on
tabletability compared to the properties of the
carrier itself (such as particle size and specific
surface area). The lowest tabletability was
observed in LS admixtures S3 and S4 with
compact tensile strength lower than 1 MPa at all
but highest compaction pressure applied.
4. CONCLUSION
Out of the three investigated carriers, Neusilin®
US2 showed the best compaction properties
despite its high liquid load. LS admixtures with
this carrier exhibited the highest values of
tensile strength and solid fraction at relatively
low compression pressures. Pronounced
differences have been noticed between the two
Syloid carriers, which indicates the effect of
carrier particle size on compaction properties of
LS admixtures.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "Comparative compression characterization of liquisolid systems prepared with mesoporous carriers",
pages = "180-181",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4750"
}

Glišić, T., German Ilić, I., Parojčić, J.,& Aleksić, I.. (2022). Comparative compression characterization of liquisolid systems prepared with mesoporous carriers. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 180-181.
https://hdl.handle.net/21.15107/rcub_farfar_4750

Glišić T, German Ilić I, Parojčić J, Aleksić I. Comparative compression characterization of liquisolid systems prepared with mesoporous carriers. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:180-181.
https://hdl.handle.net/21.15107/rcub_farfar_4750 .

Glišić, Teodora, German Ilić, Ilija, Parojčić, Jelena, Aleksić, Ivana, "Comparative compression characterization of liquisolid systems prepared with mesoporous carriers" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):180-181,
https://hdl.handle.net/21.15107/rcub_farfar_4750 .

TY  - CONF
AU  - Aleksić, Ivana
AU  - Ćirin-Varađan, Slobodanka
AU  - Glišić, Teodora
AU  - Đuriš, Mihal
AU  - Đuriš, Jelena
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4735
AB  - 1. INTRODUCTION
Co-processing has emerged as a suitable
approach to meet the increasing demands for
excipients with improved tableting
performance. Apart from the most commonly
used energy-consuming co-processing methods
(e.g. spray-drying and wet granulation), melt
granulation as a solvent-free and more
environmentally friendly technique has recently
gained more attention [1].
The aim of the present study was to investigate
the influence of meltable binder particle size
and compaction parameters on dilution capacity
and compaction behaviour of lactose-based coprocessed
excipients.
2. MATERIALS AND METHODS
2.1. Materials
Paracetamol (Acros Organics, Belgium) was
used as the model drug. Lactose monohydrate
(Carlo Erba Reagents, Italy) was used as filler
and glyceryl palmitostearate (Precirol® ATO 5
Gattefossé S.A.S, France) as meltable binder.
2.2. Preparation of co-processed excipients
Co-processed excipients were prepared by in
situ melt granulation in Mycrolab fluid bed
processor (OYSTAR Hüttlin, Germany).
Precirol® particles (15%) from the 125–180 μm
(≈ 150 μm) or 600–710 μm sieve fraction (≈ 655
μm) were used for granulation of lactose (85%).
The inlet air flow rate was 30 m3/h, and product
temperature during agglomeration was 65 °C.
2.3. Particle size and shape analysis
Granule size distribution was evaluated by sieve
analysis, and median particle diameter (d50) was
calculated by linear interpolation of the
cumulative percentage frequency curve.
Granule shape was examined by 2D scanned
image (4800 dpi resolution) analysis using
ImageJ software. The aspect ratio (AR) and
circularity (C) were calculated for granule shape
evaluation.
2.3. Determination of the Carr index
The bulk and tapped (1250 taps) densities of coprocessed
excipients and their mixtures with 30,
40 or 50% paracetamol were determined using
tap density tester STAV 2003 (J. Engelsmann
AG, Germany), and Carr index was calculated.
2.4. Dynamic compaction analysis
Co-processed excipients and their mixtures with
paracetamol were compressed on a single punch
instrumented tablet press (GTP D series,
Gamlen Tableting Ltd, UK). Compacts (100
mg) were compressed under compression load
of 200 kg (≈ 70 MPa) or 500 kg (≈ 173MPa),
and compression speed of 60 or 120 mm/min. 6
mm flat faced punches were used. The obtained
force-displacement curves were used to
calculate: net work of compression (NW),
detachment stress (DS), ejection stress (ES).
Tablet crushing force was determined using
tablet hardness tester Erweka TBH 125D
(Erweka GmbH, Germany), and the values
obtained were used to calculate tensile strength
(TS). Elastic recovery (24 h after compression)
was calculated, as well.
2.4. Experimental Design
In order to investigate the influence of binder
particle size, paracetamol content and
compression speed on the abovementioned
compaction properties, compacts were
prepared, at compression load of 500 kg,
according to 23 full factorial design.
3. RESULTS AND DISCUSSION
3.1. Particle size and shape
Larger initial binder particle size led to
formation of larger and more spherical granules
(Table 1).
147
Table 1. The size and shape of the co-processed
excipients’ particles.
Binder PS (μm) d50 AR C
150 564.9 1.33 0.81
655 846.2 1.14 0.86
3.2. Flowability
The Carr index values obtained indicated
considerably better flowability of the coprocessed
excipient prepared by using larger
binder particles (P655) in comparison with the
excipient prepared with smaller binder particles
(P150). This might be ascribed to more
spherical and larger particles of P655. However,
the addition of paracetamol led to an increase in
Carr index values and less pronounced
differences between two excipients (Fig. 1).
Figure 1. The influence of paracetamol loading
on flowability of co-processed excipients.
3.3. Compaction behaviour
The results obtained revealed better mechanical
properties of P150 in comparison with P655
compacts, irrespective of the compression
pressure applied. The addition of paracetamol,
as the model API with poor compaction
properties, led to decrease in tensile strength of
the compacts prepared with both excipients, and
paracetamol content showed statistically
significant influence on TS (p < 0.0001).
Acceptable tensile strength (> 1 MPa) could be
achieved for compacts with 30% paracetamol
compressed at higher compression pressure (≈
173 MPa).
Paracetamol content, compression speed and
interaction between binder particle size and
paracetamol content were found to significantly
affect NW. The influence of binder particle size
was more pronounced at higher paracetamol
content, with lower NW observed in the case of
P655. Higher compression speed led to higher
NW.
Relatively low values of detachment and
ejection stress (< 3.5 MPa) indicate good
antiadhesive and lubricating properties of the
investigated excipients. Lower values of both
parameters were observed in the case of P655
which could be related to different
agglomeration mechanisms involved. Besides
binder particle size, compression speed and
paracetamol content were found to significantly
influence these properties.
Elastic recovery values of the investigated
samples ranged between 12 and 28%. In the
case of both excipients, higher elastic recovery
values were obtained at higher compression
pressure. ER values of the compacts prepared at
higher compression pressure were significantly
affected by compression speed and interactions
of the investigated variables.
4. CONCLUSION
The results obtained show that meltable binder
particle size affects granule size and shape, and
consequently may influence flowability and
compaction behaviour of the co-processed
excipients. Interactions between binder particle
size and compaction variables were also found
to affect compaction properties of the
investigated excipients.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation
SP  - 146
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4735
ER  - 

@conference{
author = "Aleksić, Ivana and Ćirin-Varađan, Slobodanka and Glišić, Teodora and Đuriš, Mihal and Đuriš, Jelena and Parojčić, Jelena",
year = "2022",
abstract = "1. INTRODUCTION
Co-processing has emerged as a suitable
approach to meet the increasing demands for
excipients with improved tableting
performance. Apart from the most commonly
used energy-consuming co-processing methods
(e.g. spray-drying and wet granulation), melt
granulation as a solvent-free and more
environmentally friendly technique has recently
gained more attention [1].
The aim of the present study was to investigate
the influence of meltable binder particle size
and compaction parameters on dilution capacity
and compaction behaviour of lactose-based coprocessed
excipients.
2. MATERIALS AND METHODS
2.1. Materials
Paracetamol (Acros Organics, Belgium) was
used as the model drug. Lactose monohydrate
(Carlo Erba Reagents, Italy) was used as filler
and glyceryl palmitostearate (Precirol® ATO 5
Gattefossé S.A.S, France) as meltable binder.
2.2. Preparation of co-processed excipients
Co-processed excipients were prepared by in
situ melt granulation in Mycrolab fluid bed
processor (OYSTAR Hüttlin, Germany).
Precirol® particles (15%) from the 125–180 μm
(≈ 150 μm) or 600–710 μm sieve fraction (≈ 655
μm) were used for granulation of lactose (85%).
The inlet air flow rate was 30 m3/h, and product
temperature during agglomeration was 65 °C.
2.3. Particle size and shape analysis
Granule size distribution was evaluated by sieve
analysis, and median particle diameter (d50) was
calculated by linear interpolation of the
cumulative percentage frequency curve.
Granule shape was examined by 2D scanned
image (4800 dpi resolution) analysis using
ImageJ software. The aspect ratio (AR) and
circularity (C) were calculated for granule shape
evaluation.
2.3. Determination of the Carr index
The bulk and tapped (1250 taps) densities of coprocessed
excipients and their mixtures with 30,
40 or 50% paracetamol were determined using
tap density tester STAV 2003 (J. Engelsmann
AG, Germany), and Carr index was calculated.
2.4. Dynamic compaction analysis
Co-processed excipients and their mixtures with
paracetamol were compressed on a single punch
instrumented tablet press (GTP D series,
Gamlen Tableting Ltd, UK). Compacts (100
mg) were compressed under compression load
of 200 kg (≈ 70 MPa) or 500 kg (≈ 173MPa),
and compression speed of 60 or 120 mm/min. 6
mm flat faced punches were used. The obtained
force-displacement curves were used to
calculate: net work of compression (NW),
detachment stress (DS), ejection stress (ES).
Tablet crushing force was determined using
tablet hardness tester Erweka TBH 125D
(Erweka GmbH, Germany), and the values
obtained were used to calculate tensile strength
(TS). Elastic recovery (24 h after compression)
was calculated, as well.
2.4. Experimental Design
In order to investigate the influence of binder
particle size, paracetamol content and
compression speed on the abovementioned
compaction properties, compacts were
prepared, at compression load of 500 kg,
according to 23 full factorial design.
3. RESULTS AND DISCUSSION
3.1. Particle size and shape
Larger initial binder particle size led to
formation of larger and more spherical granules
(Table 1).
147
Table 1. The size and shape of the co-processed
excipients’ particles.
Binder PS (μm) d50 AR C
150 564.9 1.33 0.81
655 846.2 1.14 0.86
3.2. Flowability
The Carr index values obtained indicated
considerably better flowability of the coprocessed
excipient prepared by using larger
binder particles (P655) in comparison with the
excipient prepared with smaller binder particles
(P150). This might be ascribed to more
spherical and larger particles of P655. However,
the addition of paracetamol led to an increase in
Carr index values and less pronounced
differences between two excipients (Fig. 1).
Figure 1. The influence of paracetamol loading
on flowability of co-processed excipients.
3.3. Compaction behaviour
The results obtained revealed better mechanical
properties of P150 in comparison with P655
compacts, irrespective of the compression
pressure applied. The addition of paracetamol,
as the model API with poor compaction
properties, led to decrease in tensile strength of
the compacts prepared with both excipients, and
paracetamol content showed statistically
significant influence on TS (p < 0.0001).
Acceptable tensile strength (> 1 MPa) could be
achieved for compacts with 30% paracetamol
compressed at higher compression pressure (≈
173 MPa).
Paracetamol content, compression speed and
interaction between binder particle size and
paracetamol content were found to significantly
affect NW. The influence of binder particle size
was more pronounced at higher paracetamol
content, with lower NW observed in the case of
P655. Higher compression speed led to higher
NW.
Relatively low values of detachment and
ejection stress (< 3.5 MPa) indicate good
antiadhesive and lubricating properties of the
investigated excipients. Lower values of both
parameters were observed in the case of P655
which could be related to different
agglomeration mechanisms involved. Besides
binder particle size, compression speed and
paracetamol content were found to significantly
influence these properties.
Elastic recovery values of the investigated
samples ranged between 12 and 28%. In the
case of both excipients, higher elastic recovery
values were obtained at higher compression
pressure. ER values of the compacts prepared at
higher compression pressure were significantly
affected by compression speed and interactions
of the investigated variables.
4. CONCLUSION
The results obtained show that meltable binder
particle size affects granule size and shape, and
consequently may influence flowability and
compaction behaviour of the co-processed
excipients. Interactions between binder particle
size and compaction variables were also found
to affect compaction properties of the
investigated excipients.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation",
pages = "146-147",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4735"
}

Aleksić, I., Ćirin-Varađan, S., Glišić, T., Đuriš, M., Đuriš, J.,& Parojčić, J.. (2022). Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 146-147.
https://hdl.handle.net/21.15107/rcub_farfar_4735

Aleksić I, Ćirin-Varađan S, Glišić T, Đuriš M, Đuriš J, Parojčić J. Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:146-147.
https://hdl.handle.net/21.15107/rcub_farfar_4735 .

Aleksić, Ivana, Ćirin-Varađan, Slobodanka, Glišić, Teodora, Đuriš, Mihal, Đuriš, Jelena, Parojčić, Jelena, "Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):146-147,
https://hdl.handle.net/21.15107/rcub_farfar_4735 .

TY  - CONF
AU  - Glišić, Teodora
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4570
AB  - Tablet disintegration in gastrointestinal fluids and the resulting increase in surface
area available for drug dissolution is one of the preconditions for achieving acceptable
bioavailability (1). Disintegrant addition shortens the disintegration time, but it can also
affect flowability and mechanical properties of liquisolid systems (2). The aim of this study
was to examine the influence of superdisintegrant type and concentration on flowability,
tensile strength and disintegration time of liquisolid systems prepared using three different
carriers.
The admixtures were prepared in a fluid bed processor. Syloid ® XDP3050, Neusilin®
US2 and Fujicalin ® were used as carriers, with liquid phase (macrogol 400) content of
40.4%, 54.8% and 14.8%, respectively, and carrier to coating material (colloidal silicon
dioxide) ratio R=30. Superdisintegrant (croscarmellose sodium, crospovidone, sodium starch
glycolate) concentration ranged from 2 to 5%. Admixtures’ flowability and compacts’ tensile
strength and disintegration time were determined. Admixtures with Fujicalin® showed the
best flowability. Superdisintegrant addition decreased flowability, except for Syloid®
XDP3050 admixtures where flowability improved with increase in disintegrant
concentration. Sodium starch glycolate had the most pronounced influence on the compact
tensile strength. Regardless of the carrier used, the increase in its concentration led to
decrease in tensile strength. Notable differences in the disintegration time were observed,
depending on the type of carrier and superdisintegrant. Compacts with Fujicalin®
disintegrated within the required time without the superdisintegrant addition. The shortest
disintegration time, for compacts with Syloid ® XDP3050 and Neusilin® US2, as well as the
highest tensile strength, for compacts with Syloid ® XDP3050, were achieved with
croscarmellose sodium.
AB  - Raspadanje tablete u kontaktu sa gastrointestinalnim tečnostima i posledično
povećanje površine dostupne za rastvaranje lekovite supstance jedan je od preduslova za
postizanje željene biološke raspoloživosti (1). Dodatak dezintegratora u tečno-čvrste
formulacije skraćuje vreme raspadanja, ali može uticati na protočna i mehanička svojstva
pripremljenih smeša, odnosno tableta (2). Cilj ovog istraživanja bio je ispitati uticaj vrste i
koncentracije tri tipa superdezintegratora na protočnost, zateznu čvrstinu i raspadljivost
tečno-čvrstih sistema pripremljenih upotrebom tri različita nosača. Smeše su pripremljene u
uređaju tipa fluidizirajućeg sistema. Syloid ® XDP3050, Neusilin® US2 i Fujicalin® su korišćeni
kao nosači, uz udeo tečne faze (makrogol 400) od 40,4%, 54,8% i 14,8%, redom, pri odnosu
nosača i sredstva za oblaganje (koloidni silicijum-dioksid) R=30. Udeo superdezintegratora
(kroskarmeloza-natrijum, krospovidon, natrijum-skrobglikolat) variran je u opsegu 2-5%.
Ispitana je protočnost, a nakon komprimovanja na ekscentar tablet mašini, kompaktima
određene zatezna čvrstina i raspadljivost. Najbolja protočnost primećena je kod smeša sa
Fujicalin®‐om. Dodatak superdezintegratora je snižavao protočnost, osim kod smeša sa
Syloid ® XDP3050 gde se povećanjem koncentracije superdezintegratora protočnost
poboljšavala. Najizraženiji uticaj na zateznu čvrstinu kompakata, bez obzira na vrstu nosača,
pokazao je natrijum-skrobglikolat. Povećanje udela ovog superdezintegratora dovelo je do
sniženja zatezne čvrstine kod ispitivanih kompakata. Uočene su znatne razlike u vremenu
raspadanja kompakata u zavisnosti od vrste nosača i superdezintegratora, a kompakti sa
Fujicalin®‐om su se raspadali za predviđeno vreme i bez dodatka superdezintegratora.
Kroskarmeloza-natrijum je superdezintegrator sa kojim je postignuto najkraće vreme
raspadanja tečno-čvrstih kompakata sa nosačima Syloid ® XDP3050 i Neusilin® US2, kao i
najveća zatezna čvrstina za kompakte sa Syloid ® XDP3050.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers
T1  - Ispitivanje uticaja vrste superdezintegratora na svojstva tečno‐ čvrstih sistema sa različitim nosačima
VL  - 72
IS  - 4 suplement
SP  - S402
EP  - S403
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4570
ER  - 

@conference{
author = "Glišić, Teodora and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2022",
abstract = "Tablet disintegration in gastrointestinal fluids and the resulting increase in surface
area available for drug dissolution is one of the preconditions for achieving acceptable
bioavailability (1). Disintegrant addition shortens the disintegration time, but it can also
affect flowability and mechanical properties of liquisolid systems (2). The aim of this study
was to examine the influence of superdisintegrant type and concentration on flowability,
tensile strength and disintegration time of liquisolid systems prepared using three different
carriers.
The admixtures were prepared in a fluid bed processor. Syloid ® XDP3050, Neusilin®
US2 and Fujicalin ® were used as carriers, with liquid phase (macrogol 400) content of
40.4%, 54.8% and 14.8%, respectively, and carrier to coating material (colloidal silicon
dioxide) ratio R=30. Superdisintegrant (croscarmellose sodium, crospovidone, sodium starch
glycolate) concentration ranged from 2 to 5%. Admixtures’ flowability and compacts’ tensile
strength and disintegration time were determined. Admixtures with Fujicalin® showed the
best flowability. Superdisintegrant addition decreased flowability, except for Syloid®
XDP3050 admixtures where flowability improved with increase in disintegrant
concentration. Sodium starch glycolate had the most pronounced influence on the compact
tensile strength. Regardless of the carrier used, the increase in its concentration led to
decrease in tensile strength. Notable differences in the disintegration time were observed,
depending on the type of carrier and superdisintegrant. Compacts with Fujicalin®
disintegrated within the required time without the superdisintegrant addition. The shortest
disintegration time, for compacts with Syloid ® XDP3050 and Neusilin® US2, as well as the
highest tensile strength, for compacts with Syloid ® XDP3050, were achieved with
croscarmellose sodium., Raspadanje tablete u kontaktu sa gastrointestinalnim tečnostima i posledično
povećanje površine dostupne za rastvaranje lekovite supstance jedan je od preduslova za
postizanje željene biološke raspoloživosti (1). Dodatak dezintegratora u tečno-čvrste
formulacije skraćuje vreme raspadanja, ali može uticati na protočna i mehanička svojstva
pripremljenih smeša, odnosno tableta (2). Cilj ovog istraživanja bio je ispitati uticaj vrste i
koncentracije tri tipa superdezintegratora na protočnost, zateznu čvrstinu i raspadljivost
tečno-čvrstih sistema pripremljenih upotrebom tri različita nosača. Smeše su pripremljene u
uređaju tipa fluidizirajućeg sistema. Syloid ® XDP3050, Neusilin® US2 i Fujicalin® su korišćeni
kao nosači, uz udeo tečne faze (makrogol 400) od 40,4%, 54,8% i 14,8%, redom, pri odnosu
nosača i sredstva za oblaganje (koloidni silicijum-dioksid) R=30. Udeo superdezintegratora
(kroskarmeloza-natrijum, krospovidon, natrijum-skrobglikolat) variran je u opsegu 2-5%.
Ispitana je protočnost, a nakon komprimovanja na ekscentar tablet mašini, kompaktima
određene zatezna čvrstina i raspadljivost. Najbolja protočnost primećena je kod smeša sa
Fujicalin®‐om. Dodatak superdezintegratora je snižavao protočnost, osim kod smeša sa
Syloid ® XDP3050 gde se povećanjem koncentracije superdezintegratora protočnost
poboljšavala. Najizraženiji uticaj na zateznu čvrstinu kompakata, bez obzira na vrstu nosača,
pokazao je natrijum-skrobglikolat. Povećanje udela ovog superdezintegratora dovelo je do
sniženja zatezne čvrstine kod ispitivanih kompakata. Uočene su znatne razlike u vremenu
raspadanja kompakata u zavisnosti od vrste nosača i superdezintegratora, a kompakti sa
Fujicalin®‐om su se raspadali za predviđeno vreme i bez dodatka superdezintegratora.
Kroskarmeloza-natrijum je superdezintegrator sa kojim je postignuto najkraće vreme
raspadanja tečno-čvrstih kompakata sa nosačima Syloid ® XDP3050 i Neusilin® US2, kao i
najveća zatezna čvrstina za kompakte sa Syloid ® XDP3050.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers, Ispitivanje uticaja vrste superdezintegratora na svojstva tečno‐ čvrstih sistema sa različitim nosačima",
volume = "72",
number = "4 suplement",
pages = "S402-S403",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4570"
}

Glišić, T., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2022). An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S402-S403.
https://hdl.handle.net/21.15107/rcub_farfar_4570

Glišić T, Vasiljević I, Parojčić J, Aleksić I. An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers. in Arhiv za farmaciju. 2022;72(4 suplement):S402-S403.
https://hdl.handle.net/21.15107/rcub_farfar_4570 .

Glišić, Teodora, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "An investigation into the influence of superdisintegrant type on properties of liquisolid systems with different carriers" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S402-S403,
https://hdl.handle.net/21.15107/rcub_farfar_4570 .

TY  - JOUR
AU  - Aleksić, Ivana
AU  - Glišić, Teodora
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4406
AB  - Liquisolid systems are a novel, promising platform for the production of solid dosage forms
with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid
vehicle or liquid drug. This technology requires conventional, but highly porous excipients
(carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication,
resulting in both good flowability and acceptable compression properties. This approach has
shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs,
and has been recognized as a good alternative to common, more complex and expensive
techniques. A variety of applications of this simple technique have been investigated recently,
including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage
forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and
the most important are: simplicity, cost-effectiveness, applicability in large scale production and
environmental friendliness. However, it is accompanied by certain challenges as well, such as
limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive
overview of recent progress regarding the potential applications of this technology, as well as to
give an insight into the new liquisolid-based techniques intending to further support its
commercial applicability.
AB  - Tečno-čvrsti sistemi su nova, obećavajuća platforma za proizvodnju čvrstih farmaceutskih oblika sa visokim sadržajem tečnosti, odnosno disperzije lekovite supstance u pogodnom, hidrofilnom i neisparljivom tečnom vehikulumu ili same lekovite supstance u tečnom agregatnom stanju. Ova tehnologija podrazumeva upotrebu konvencionalnih, ali visoko poroznih ekscipijenasa (nosača i sredstva za oblaganje u odgovarajućem odnosu) koji mogu da absorbuju/adsorbuju tečnost uz zadržavanje dobre protočnosti i prihvatljivih svojstava pri kompresiji. Ovaj pristup je pokazao značajan potencijal da poboljša brzinu rastvaranja i bioraspoloživost slabo rastvorljivih lekovitih supstanci, a prepoznat je kao dobra alternativa uobičajeno primenjivanim, znatno složenijim i skupljim tehnikama. Pored toga, nedavno su istraživane brojne mogućnosti za primenu ove jednostavne tehnike, uključujući izradu: tableta sa modifikovanim oslobađanjem lekovite supstance, oralno disperzibilnih tableta, čvrstih farmaceutskih oblika sa tečnim biljnim ekstraktima, itd. Ova nova tehnologija pruža brojne prednosti, među kojima su najvažnije njena jednostavnost, ekonomičnost, primenljivost u industrijskoj proizvodnji i ekološka prihvatljivost. Međutim, prate je i izvesni izazovi, kao što je ograničena primenljivost u slučaju visoko doziranih lekovitih supstanci. Ovaj rad ima za cilj da pruži sveobuhvatan pregled nedavnog napretka u pogledu potencijalne primene ove tehnologije, kao i da pruži uvid u nove tehnike zasnovane na konceptu tečno-čvrstih sistema koje teže da dalje prošire njenu komercijalnu primenu.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives
T1  - Tečno-čvrsti sistemi kao novi pristup razvoju formulacija i proizvodnji čvrstih farmaceutskih oblika lekova - izazovi i perspektive
VL  - 72
IS  - 6
SP  - 521
EP  - 545
DO  - 10.5937/arhfarm72-40329
ER  - 

@article{
author = "Aleksić, Ivana and Glišić, Teodora and Parojčić, Jelena",
year = "2022",
abstract = "Liquisolid systems are a novel, promising platform for the production of solid dosage forms
with a high liquid content, i.e. dispersion of the drug in a suitable, hydrophilic, non-volatile liquid
vehicle or liquid drug. This technology requires conventional, but highly porous excipients
(carrier and coating material in the appropriate ratio) able to absorb/adsorb liquid medication,
resulting in both good flowability and acceptable compression properties. This approach has
shown great potential to improve the dissolution rate and bioavailability of poorly soluble drugs,
and has been recognized as a good alternative to common, more complex and expensive
techniques. A variety of applications of this simple technique have been investigated recently,
including the preparation of: modified release tablets, orally disintegrating tablets, solid dosage
forms with liquid herbal extracts, etc. This emerging technology has numerous advantages, and
the most important are: simplicity, cost-effectiveness, applicability in large scale production and
environmental friendliness. However, it is accompanied by certain challenges as well, such as
limited applicability in the case of highly dosed drugs. This article aims to give a comprehensive
overview of recent progress regarding the potential applications of this technology, as well as to
give an insight into the new liquisolid-based techniques intending to further support its
commercial applicability., Tečno-čvrsti sistemi su nova, obećavajuća platforma za proizvodnju čvrstih farmaceutskih oblika sa visokim sadržajem tečnosti, odnosno disperzije lekovite supstance u pogodnom, hidrofilnom i neisparljivom tečnom vehikulumu ili same lekovite supstance u tečnom agregatnom stanju. Ova tehnologija podrazumeva upotrebu konvencionalnih, ali visoko poroznih ekscipijenasa (nosača i sredstva za oblaganje u odgovarajućem odnosu) koji mogu da absorbuju/adsorbuju tečnost uz zadržavanje dobre protočnosti i prihvatljivih svojstava pri kompresiji. Ovaj pristup je pokazao značajan potencijal da poboljša brzinu rastvaranja i bioraspoloživost slabo rastvorljivih lekovitih supstanci, a prepoznat je kao dobra alternativa uobičajeno primenjivanim, znatno složenijim i skupljim tehnikama. Pored toga, nedavno su istraživane brojne mogućnosti za primenu ove jednostavne tehnike, uključujući izradu: tableta sa modifikovanim oslobađanjem lekovite supstance, oralno disperzibilnih tableta, čvrstih farmaceutskih oblika sa tečnim biljnim ekstraktima, itd. Ova nova tehnologija pruža brojne prednosti, među kojima su najvažnije njena jednostavnost, ekonomičnost, primenljivost u industrijskoj proizvodnji i ekološka prihvatljivost. Međutim, prate je i izvesni izazovi, kao što je ograničena primenljivost u slučaju visoko doziranih lekovitih supstanci. Ovaj rad ima za cilj da pruži sveobuhvatan pregled nedavnog napretka u pogledu potencijalne primene ove tehnologije, kao i da pruži uvid u nove tehnike zasnovane na konceptu tečno-čvrstih sistema koje teže da dalje prošire njenu komercijalnu primenu.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives, Tečno-čvrsti sistemi kao novi pristup razvoju formulacija i proizvodnji čvrstih farmaceutskih oblika lekova - izazovi i perspektive",
volume = "72",
number = "6",
pages = "521-545",
doi = "10.5937/arhfarm72-40329"
}

Aleksić, I., Glišić, T.,& Parojčić, J.. (2022). Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 521-545.
https://doi.org/10.5937/arhfarm72-40329

Aleksić I, Glišić T, Parojčić J. Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives. in Arhiv za farmaciju. 2022;72(6):521-545.
doi:10.5937/arhfarm72-40329 .

Aleksić, Ivana, Glišić, Teodora, Parojčić, Jelena, "Liquisolid systems as a novel approach in formulation and manufacturing of solid dosage forms: Challenges and perspectives" in Arhiv za farmaciju, 72, no. 6 (2022):521-545,
https://doi.org/10.5937/arhfarm72-40329 . .

TY  - JOUR
AU  - Aleksić, Ivana
AU  - Glišić, Teodora
AU  - Cvijić, Sandra
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4244
AB  - Liquisolid systems represent an emerging approach in the preparation of solid dosage forms with liquid lipophilic drug or poorly water-soluble drug solution/suspension in suitable liquid vehicle. This study addresses the lack of data regarding the compaction behavior of liquisolid systems, with the aim to investigate the influence of liquid load, carrier to coating ratio, carrier type (microcrystalline cellulose vs. spray dried calcium hydrogen phosphate, anhydrous (Fujicalin ® )) on flowability and compaction properties of liquisolid systems and to determine the optimum liquid loads. Liquisolid admixtures with Fujicalin® showed notably better flowability than those with microcrystalline cellulose. An increase in carrier to coating ratio led to enhanced flowability of the admixtures. Compacts with Fujicalin® had good mechanical properties up to 24.7% liquid, while those with microcrystalline cellulose had acceptable mechanical strength up to 16.2% liquid. Liquisolid systems with Fujicalin® showed similar tabletability profiles as those with microcrystalline cellulose, despite having higher liquid content. The ejection stress values indicated that the addition of lubricant might be needed in the case of liquisolid systems with Fujicalin ® . Superior properties of Fujicalin ® as a carrier for liquisolid tablets were revealed, and dynamic compaction analysis was found to be a valuable tool for the assessment of compaction behavior of liquisolid systems.
AB  - Tečno-čvrsti sistemi predstavljaju novi pristup izradi čvrstih farmaceutskih oblika koji sadrže tečnu lipofilnu lekovitu supstancu ili rastvor/suspenziju slabo rastvorljive lekovite supstance u pogodnom vehikulumu. Imajući u vidu nedostatak literaturnih podataka o ponašanju tečno-čvrstih sistema pri kompresiji, cilj ovog istraživanja je ispitivanje uticaja opterećenja tečnošću, odnosa nosača i sredstva za oblaganje, kao i vrste nosača (mikrokristalna celuloza i bezvodni kalcijum-hidrogenfosfat sušen raspršivanjem (Fujicalin ® )) na protočnost i svojstva tečno-čvrstih sistema pri kompresiji, kao i određivanje optimalnog opterećenja tečnošću. Tečno- čvrste smeše sa Fujicalin ® -om su pokazale znatno bolju protočnost nego smeše sa mikrokristalnom celulozom. Uočeno je da se sa povećanjem odnosa nosača i sredstva za oblaganje poboljšava protočnost smeša. Kompakti sa Fujicalin ® -om su imali dobra mehanička svojstva do udela od 24,7% tečnosti, a kompakti sa mikrokristalnom celulozom do udela od 16,2% tečnosti. Tečno-čvrsti sistemi sa Fujicalin ® -om su pokazali slične profile tabletabilnosti onim sa mikrokristalnom celulozom, uprkos tome što sadrže znatno veći udeo tečnosti. Vrednosti pritiska potrebnog za izbacivanje kompakta iz matrice ukazuju da bi dodatak lubrikansa mogao biti potreban u slučaju tečno-čvrstih sistema sa Fujicalin ® -om. Dobijeni rezultati ukazuju na superiorna svojstva Fujicalin ® -a kao nosača u tečno-čvrstim tabletama, a dinamička analiza kompakcije može predstavljati koristan alat za procenu ponašanja tečno-čvrstih sistema pri kompresiji.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load
T1  - Tečno-čvrsti sistemi: Ispitivanje uticaja faktora formulacije na optimalno opterećenje tečnošću
VL  - 72
IS  - 1
SP  - 61
EP  - 76
DO  - 10.5937/arhfarm72-33130
ER  - 

@article{
author = "Aleksić, Ivana and Glišić, Teodora and Cvijić, Sandra and Parojčić, Jelena",
year = "2022",
abstract = "Liquisolid systems represent an emerging approach in the preparation of solid dosage forms with liquid lipophilic drug or poorly water-soluble drug solution/suspension in suitable liquid vehicle. This study addresses the lack of data regarding the compaction behavior of liquisolid systems, with the aim to investigate the influence of liquid load, carrier to coating ratio, carrier type (microcrystalline cellulose vs. spray dried calcium hydrogen phosphate, anhydrous (Fujicalin ® )) on flowability and compaction properties of liquisolid systems and to determine the optimum liquid loads. Liquisolid admixtures with Fujicalin® showed notably better flowability than those with microcrystalline cellulose. An increase in carrier to coating ratio led to enhanced flowability of the admixtures. Compacts with Fujicalin® had good mechanical properties up to 24.7% liquid, while those with microcrystalline cellulose had acceptable mechanical strength up to 16.2% liquid. Liquisolid systems with Fujicalin® showed similar tabletability profiles as those with microcrystalline cellulose, despite having higher liquid content. The ejection stress values indicated that the addition of lubricant might be needed in the case of liquisolid systems with Fujicalin ® . Superior properties of Fujicalin ® as a carrier for liquisolid tablets were revealed, and dynamic compaction analysis was found to be a valuable tool for the assessment of compaction behavior of liquisolid systems., Tečno-čvrsti sistemi predstavljaju novi pristup izradi čvrstih farmaceutskih oblika koji sadrže tečnu lipofilnu lekovitu supstancu ili rastvor/suspenziju slabo rastvorljive lekovite supstance u pogodnom vehikulumu. Imajući u vidu nedostatak literaturnih podataka o ponašanju tečno-čvrstih sistema pri kompresiji, cilj ovog istraživanja je ispitivanje uticaja opterećenja tečnošću, odnosa nosača i sredstva za oblaganje, kao i vrste nosača (mikrokristalna celuloza i bezvodni kalcijum-hidrogenfosfat sušen raspršivanjem (Fujicalin ® )) na protočnost i svojstva tečno-čvrstih sistema pri kompresiji, kao i određivanje optimalnog opterećenja tečnošću. Tečno- čvrste smeše sa Fujicalin ® -om su pokazale znatno bolju protočnost nego smeše sa mikrokristalnom celulozom. Uočeno je da se sa povećanjem odnosa nosača i sredstva za oblaganje poboljšava protočnost smeša. Kompakti sa Fujicalin ® -om su imali dobra mehanička svojstva do udela od 24,7% tečnosti, a kompakti sa mikrokristalnom celulozom do udela od 16,2% tečnosti. Tečno-čvrsti sistemi sa Fujicalin ® -om su pokazali slične profile tabletabilnosti onim sa mikrokristalnom celulozom, uprkos tome što sadrže znatno veći udeo tečnosti. Vrednosti pritiska potrebnog za izbacivanje kompakta iz matrice ukazuju da bi dodatak lubrikansa mogao biti potreban u slučaju tečno-čvrstih sistema sa Fujicalin ® -om. Dobijeni rezultati ukazuju na superiorna svojstva Fujicalin ® -a kao nosača u tečno-čvrstim tabletama, a dinamička analiza kompakcije može predstavljati koristan alat za procenu ponašanja tečno-čvrstih sistema pri kompresiji.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load, Tečno-čvrsti sistemi: Ispitivanje uticaja faktora formulacije na optimalno opterećenje tečnošću",
volume = "72",
number = "1",
pages = "61-76",
doi = "10.5937/arhfarm72-33130"
}

Aleksić, I., Glišić, T., Cvijić, S.,& Parojčić, J.. (2022). Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(1), 61-76.
https://doi.org/10.5937/arhfarm72-33130

Aleksić I, Glišić T, Cvijić S, Parojčić J. Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load. in Arhiv za farmaciju. 2022;72(1):61-76.
doi:10.5937/arhfarm72-33130 .

Aleksić, Ivana, Glišić, Teodora, Cvijić, Sandra, Parojčić, Jelena, "Liquisolid systems: Evaluation of the influence of formulation variables on the optimum liquid load" in Arhiv za farmaciju, 72, no. 1 (2022):61-76,
https://doi.org/10.5937/arhfarm72-33130 . .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Piller, Michael
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4318
AB  - 3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), using different polymers, and investigate their processability based on the SeDeM Expert System approach. MPUs (1- or 2-mm size) were prepared with model drug (ibuprofen or caffeine), polymer (poly(ethylene)oxide (PEO), ethyl cellulose (EC) or methacrylic acid-ethyl acrylate copolymer (MA-EA)) and printing aid. Comprehensive sample characterization was performed and experimentally obtained parameters were mathematically transformed and evaluated using the SeDeM Expert System framework. The obtained samples exhibited irregular shape, despite the spherical printing object design. Polymer incorporated notably affected MPUs properties. The obtained samples exhibited low bulk density, good flowability-, as well as stability-related parameters, which indicated their suitability for filling into capsules or sachets. Low density values implied that compressibility enhancing excipients may be required for MPUs incorporation in tablets. Samples containing EC and MA-EA were found suitable for compression, due to high compacts tensile strength. The obtained results indicate that SeDeM Expert System may extended from powder compressibility evaluation tool to framework facilitating powders/multiparticulate units processing.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach
VL  - 629
DO  - 10.1016/j.ijpharm.2022.122337
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Piller, Michael and Mirković, Miljana and Zimmer, Andreas and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), using different polymers, and investigate their processability based on the SeDeM Expert System approach. MPUs (1- or 2-mm size) were prepared with model drug (ibuprofen or caffeine), polymer (poly(ethylene)oxide (PEO), ethyl cellulose (EC) or methacrylic acid-ethyl acrylate copolymer (MA-EA)) and printing aid. Comprehensive sample characterization was performed and experimentally obtained parameters were mathematically transformed and evaluated using the SeDeM Expert System framework. The obtained samples exhibited irregular shape, despite the spherical printing object design. Polymer incorporated notably affected MPUs properties. The obtained samples exhibited low bulk density, good flowability-, as well as stability-related parameters, which indicated their suitability for filling into capsules or sachets. Low density values implied that compressibility enhancing excipients may be required for MPUs incorporation in tablets. Samples containing EC and MA-EA were found suitable for compression, due to high compacts tensile strength. The obtained results indicate that SeDeM Expert System may extended from powder compressibility evaluation tool to framework facilitating powders/multiparticulate units processing.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach",
volume = "629",
doi = "10.1016/j.ijpharm.2022.122337"
}

Vasiljević, I., Turković, E., Piller, M., Mirković, M., Zimmer, A., Aleksić, I., Ibrić, S.,& Parojčić, J.. (2022). Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 629.
https://doi.org/10.1016/j.ijpharm.2022.122337

Vasiljević I, Turković E, Piller M, Mirković M, Zimmer A, Aleksić I, Ibrić S, Parojčić J. Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2022;629.
doi:10.1016/j.ijpharm.2022.122337 .

Vasiljević, Ivana, Turković, Erna, Piller, Michael, Mirković, Miljana, Zimmer, Andreas, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, "Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach" in International Journal of Pharmaceutics, 629 (2022),
https://doi.org/10.1016/j.ijpharm.2022.122337 . .

TY  - JOUR
AU  - Ćirin-Varađan, Slobodanka
AU  - Đuriš, Jelena
AU  - Mirković, Miljana
AU  - Ivanović, Marija
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4001
AB  - The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of coprocessed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as a promising co-processing technique. The aim of the present study was to prepare lipid-based co-processed excipients by in situ fluidized bed melt granulation and to investigated their suitability for direct compression process. Lactose monohydrate was co-processed with glyceryl dibehenate (Compritol® 888 ATO) or glyceryl palmitostearate (Precirol® ATO 5), as lipophilic meltable binders. Besides the flowability testing, dynamic compaction analysis was applied for thorough investigation into the tableting properties of developed coprocessed excipients. Solid state characterization, performed by means of XRPD and DRIFT, confirmed the absence of chemical changes of the single components of co-processed excipients. Co-processed excipients showed improved flowability in comparison with single ingredients and corresponding physical mixtures. Novel co-processed excipients were found to have better tabletability profiles than physical mixtures of the ingredients, and were able to retain acceptable tensile strength values at high content of paracetamol in tableting mixture. Tablets with high tensile strength could be obtained with less work of compression needed in comparison with the commercial lactose-based excipients. Furthermore, novel lipid-based co-processed excipients were found to be highly superior regarding the antiadhesive and lubricating properties, with no additional lubricants required.
PB  - Elsevier B.V.
T2  - Journal of Drug Delivery Science and Technology
T1  - Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders
VL  - 67
DO  - 10.1016/j.jddst.2021.102981
ER  - 

@article{
author = "Ćirin-Varađan, Slobodanka and Đuriš, Jelena and Mirković, Miljana and Ivanović, Marija and Parojčić, Jelena and Aleksić, Ivana",
year = "2022",
abstract = "The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of coprocessed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as a promising co-processing technique. The aim of the present study was to prepare lipid-based co-processed excipients by in situ fluidized bed melt granulation and to investigated their suitability for direct compression process. Lactose monohydrate was co-processed with glyceryl dibehenate (Compritol® 888 ATO) or glyceryl palmitostearate (Precirol® ATO 5), as lipophilic meltable binders. Besides the flowability testing, dynamic compaction analysis was applied for thorough investigation into the tableting properties of developed coprocessed excipients. Solid state characterization, performed by means of XRPD and DRIFT, confirmed the absence of chemical changes of the single components of co-processed excipients. Co-processed excipients showed improved flowability in comparison with single ingredients and corresponding physical mixtures. Novel co-processed excipients were found to have better tabletability profiles than physical mixtures of the ingredients, and were able to retain acceptable tensile strength values at high content of paracetamol in tableting mixture. Tablets with high tensile strength could be obtained with less work of compression needed in comparison with the commercial lactose-based excipients. Furthermore, novel lipid-based co-processed excipients were found to be highly superior regarding the antiadhesive and lubricating properties, with no additional lubricants required.",
publisher = "Elsevier B.V.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders",
volume = "67",
doi = "10.1016/j.jddst.2021.102981"
}

Ćirin-Varađan, S., Đuriš, J., Mirković, M., Ivanović, M., Parojčić, J.,& Aleksić, I.. (2022). Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. in Journal of Drug Delivery Science and Technology
Elsevier B.V.., 67.
https://doi.org/10.1016/j.jddst.2021.102981

Ćirin-Varađan S, Đuriš J, Mirković M, Ivanović M, Parojčić J, Aleksić I. Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. in Journal of Drug Delivery Science and Technology. 2022;67.
doi:10.1016/j.jddst.2021.102981 .

Ćirin-Varađan, Slobodanka, Đuriš, Jelena, Mirković, Miljana, Ivanović, Marija, Parojčić, Jelena, Aleksić, Ivana, "Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders" in Journal of Drug Delivery Science and Technology, 67 (2022),
https://doi.org/10.1016/j.jddst.2021.102981 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5317
AB  - Additive manufacturing represents an emerging shift in the
pharmaceutical research, due to the opportunity for dosage
form individualization to the patient’s needs. Selective laser
sintering (SLS) is a novel 3D printing technology recently
introduced as the drug preparation method (1). Its potential
in the different dosage forms preparation, mainly tablets,
e.g. orodispersible tablets, was described in the literature
(2). However, the attempts in 3D printing of
multiparticulate dosage forms are scarce (3) and no SLS
printed granules were described in the literature.
The aim of this work was to prepare granules by SLS
printing and investigate the effect of formulation factors
(polymer type, model drug and particle size) on the critical
quality attributes of the obtained granules. ...
C3  - 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands
T1  - An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5317
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "Additive manufacturing represents an emerging shift in the
pharmaceutical research, due to the opportunity for dosage
form individualization to the patient’s needs. Selective laser
sintering (SLS) is a novel 3D printing technology recently
introduced as the drug preparation method (1). Its potential
in the different dosage forms preparation, mainly tablets,
e.g. orodispersible tablets, was described in the literature
(2). However, the attempts in 3D printing of
multiparticulate dosage forms are scarce (3) and no SLS
printed granules were described in the literature.
The aim of this work was to prepare granules by SLS
printing and investigate the effect of formulation factors
(polymer type, model drug and particle size) on the critical
quality attributes of the obtained granules. ...",
journal = "13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands",
title = "An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5317"
}

Vasiljević, I., Turković, E., Aleksić, I., Ibrić, S.,& Parojčić, J.. (2022). An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering. in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands.
https://hdl.handle.net/21.15107/rcub_farfar_5317

Vasiljević I, Turković E, Aleksić I, Ibrić S, Parojčić J. An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering. in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands. 2022;.
https://hdl.handle.net/21.15107/rcub_farfar_5317 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, "An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering" in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands (2022),
https://hdl.handle.net/21.15107/rcub_farfar_5317 .

TY  - CONF
AU  - Lazić, Irina
AU  - Kučević, Sabina
AU  - Ćirin-Varađan, Slobodanka
AU  - Aleksić, Ivana
AU  - Đuriš, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4569
AB  - Formulation of modified-release ibuprofen tablets presents a challenge due to its high
dose, limited compressibility and compactibility. The potential for preparing ibuprofen
modified release matrix tablets, by direct compression procedure using co-processed
excipients (1, 2), was evaluated. Co-processed excipients of hydrophilic and lipid properties
were used. Commercially available co-processed excipient based on
hydroxypropylmethylcellulose and lactose (RetaLac ®), as well as co-processed excipient
made in-house, using lipid matrix forming agent based on glyceryl palmitostearate
(Precirol® ) and lactose were used. The influence of co-processed excipient type, ibuprofen
ammount in tablets (25% and 50%) and the compression load (100 and 500 kg) on the
mechanical properties of the hydrophilic or lipid matrix tablets was evaluated. Also,
ibuprofen release rate was investigated in a rotating paddle apparatus with medium change
(0.1M HCl and phosphate buffer pH 6.8). The tensile strength of formulations was in the
range of 0.5-2 MPa. The compression load and the co-processed excipient type showed a
significant effect on tensile strength. Ibuprofen was released in a sustained manner from all
formulations, with the amount released after 8 hours varying from 35 to 80%, depending on
the matrix forming material type. The release of ibuprofen from lipid matrix tablets was
slower compared to hydrophilic tablets, with neither the compression load nor the ibuprofen
content showing a significant effect. Zero-order kinetics was achieved from both types of
matrix tablets. Based on the obtained results, it can be concluded that co-processed
excipients enable direct compression of ibuprofen modified release hydrophilic and lipid
matrix tablets.
AB  - Formulacija tableta sa modifikovanim oslobađanjem ibuprofena predstavlja izazov
zbog visoke doze lekovite supstance ograničene kompresibilnosti i kompaktibilnosti. U ovom
radu procenjena je mogućnost izrade matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije uz primenu koprocesovanih ekscipijenasa (1, 2).
Upotrebljeni su koprocesovani ekscipijensi hidrofilnih i lipidnih karakteristika. Korišćeni su
komercijalno dostupan koprocesovani ekscipijens na bazi hidroksipropilmetilceluloze i
laktoze (RetaLac® ), kao i koprocesovani ekscipijens izrađen u laboratorijskim uslovima, kao
lipidno matriks formirajuće sredstvo na bazi glicerilpalmitostearata (Precirol ®) i laktoze.
Praćen je uticaj vrste koprocesovanog ekscipijensa, udela ibuprofena u tabletama (25%,
odnosno 50%) i opterećenja pri kompresiji (100, odnosno 500 kg) na mehaničke
karakteristike izrađenih hidrofilnih, odnosno lipidnih matriks tableta. Takođe, ispitivana je
brzina oslobađanja ibuprofena iz pripremljenih matriks tableta u aparaturi sa rotirajućim
lopaticama uz izmenu medijuma (0,1M HCl i fosfatni pufer pH 6,8). Zatezna čvrstoća
ispitivanih formulacija je bila u opsegu ~ 0.5-2 MPa. Opterećenje pri kompresiji i tip
koprocesovanog ekscipijensa su pokazali značajan uticaj na zateznu čvrstoću. Ibuprofen se iz
svih formulacija oslobađao usporeno, pri čemu je količina oslobođena nakon 8 sati
ispitivanja varirala od 35 do 80%, u zavisnosti od prirode matriks formirajućeg materijala.
Oslobađanje ibuprofena iz lipidnih matriks tableta je bilo sporije u poređenju sa hidrofilnim
tabletama, pri čemu ni opterećenje pri kompresiji ni udeo ibuprofena nisu pokazali značajan
uticaj. Iz oba tipa matriks tableta postignuto je oslobađanje ibuprofena kinetikom nultog
reda. Na osnovu dobijenih rezultata može se zaključiti da koprocesovani ekscipijensi
omogućavaju izradu hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients
T1  - Formulacija hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem ibuprofena primenom koprocesovanih ekscipijenasa
VL  - 72
IS  - 4 suplement
SP  - S3400
EP  - S401
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4569
ER  - 

@conference{
author = "Lazić, Irina and Kučević, Sabina and Ćirin-Varađan, Slobodanka and Aleksić, Ivana and Đuriš, Jelena",
year = "2022",
abstract = "Formulation of modified-release ibuprofen tablets presents a challenge due to its high
dose, limited compressibility and compactibility. The potential for preparing ibuprofen
modified release matrix tablets, by direct compression procedure using co-processed
excipients (1, 2), was evaluated. Co-processed excipients of hydrophilic and lipid properties
were used. Commercially available co-processed excipient based on
hydroxypropylmethylcellulose and lactose (RetaLac ®), as well as co-processed excipient
made in-house, using lipid matrix forming agent based on glyceryl palmitostearate
(Precirol® ) and lactose were used. The influence of co-processed excipient type, ibuprofen
ammount in tablets (25% and 50%) and the compression load (100 and 500 kg) on the
mechanical properties of the hydrophilic or lipid matrix tablets was evaluated. Also,
ibuprofen release rate was investigated in a rotating paddle apparatus with medium change
(0.1M HCl and phosphate buffer pH 6.8). The tensile strength of formulations was in the
range of 0.5-2 MPa. The compression load and the co-processed excipient type showed a
significant effect on tensile strength. Ibuprofen was released in a sustained manner from all
formulations, with the amount released after 8 hours varying from 35 to 80%, depending on
the matrix forming material type. The release of ibuprofen from lipid matrix tablets was
slower compared to hydrophilic tablets, with neither the compression load nor the ibuprofen
content showing a significant effect. Zero-order kinetics was achieved from both types of
matrix tablets. Based on the obtained results, it can be concluded that co-processed
excipients enable direct compression of ibuprofen modified release hydrophilic and lipid
matrix tablets., Formulacija tableta sa modifikovanim oslobađanjem ibuprofena predstavlja izazov
zbog visoke doze lekovite supstance ograničene kompresibilnosti i kompaktibilnosti. U ovom
radu procenjena je mogućnost izrade matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije uz primenu koprocesovanih ekscipijenasa (1, 2).
Upotrebljeni su koprocesovani ekscipijensi hidrofilnih i lipidnih karakteristika. Korišćeni su
komercijalno dostupan koprocesovani ekscipijens na bazi hidroksipropilmetilceluloze i
laktoze (RetaLac® ), kao i koprocesovani ekscipijens izrađen u laboratorijskim uslovima, kao
lipidno matriks formirajuće sredstvo na bazi glicerilpalmitostearata (Precirol ®) i laktoze.
Praćen je uticaj vrste koprocesovanog ekscipijensa, udela ibuprofena u tabletama (25%,
odnosno 50%) i opterećenja pri kompresiji (100, odnosno 500 kg) na mehaničke
karakteristike izrađenih hidrofilnih, odnosno lipidnih matriks tableta. Takođe, ispitivana je
brzina oslobađanja ibuprofena iz pripremljenih matriks tableta u aparaturi sa rotirajućim
lopaticama uz izmenu medijuma (0,1M HCl i fosfatni pufer pH 6,8). Zatezna čvrstoća
ispitivanih formulacija je bila u opsegu ~ 0.5-2 MPa. Opterećenje pri kompresiji i tip
koprocesovanog ekscipijensa su pokazali značajan uticaj na zateznu čvrstoću. Ibuprofen se iz
svih formulacija oslobađao usporeno, pri čemu je količina oslobođena nakon 8 sati
ispitivanja varirala od 35 do 80%, u zavisnosti od prirode matriks formirajućeg materijala.
Oslobađanje ibuprofena iz lipidnih matriks tableta je bilo sporije u poređenju sa hidrofilnim
tabletama, pri čemu ni opterećenje pri kompresiji ni udeo ibuprofena nisu pokazali značajan
uticaj. Iz oba tipa matriks tableta postignuto je oslobađanje ibuprofena kinetikom nultog
reda. Na osnovu dobijenih rezultata može se zaključiti da koprocesovani ekscipijensi
omogućavaju izradu hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients, Formulacija hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem ibuprofena primenom koprocesovanih ekscipijenasa",
volume = "72",
number = "4 suplement",
pages = "S3400-S401",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4569"
}

Lazić, I., Kučević, S., Ćirin-Varađan, S., Aleksić, I.,& Đuriš, J.. (2022). Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S3400-S401.
https://hdl.handle.net/21.15107/rcub_farfar_4569

Lazić I, Kučević S, Ćirin-Varađan S, Aleksić I, Đuriš J. Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients. in Arhiv za farmaciju. 2022;72(4 suplement):S3400-S401.
https://hdl.handle.net/21.15107/rcub_farfar_4569 .

Lazić, Irina, Kučević, Sabina, Ćirin-Varađan, Slobodanka, Aleksić, Ivana, Đuriš, Jelena, "Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S3400-S401,
https://hdl.handle.net/21.15107/rcub_farfar_4569 .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4409
AB  - An understanding of material properties and processing effects on solid dosage forms
performance is required within the Quality-by-design approach to pharmaceutical development.
Several research groups have developed mathematical approaches aiming to facilitate the
selection of formulation composition and the manufacturing technology. These approaches are
based on material particulate, bulk and compression-related properties. This paper provides
theoretical assumptions and a critical review of different mathematical approaches for
processability characterization of powders and multiparticulate units.
Mathematical approaches have mainly been developed for directly compressible materials,
but sometimes other manufacturing technologies, such as roller compaction and wet granulation,
are also considered. The obtained compact tensile strength has been implemented in the majority
of approaches, as an important characteristic describing compact mechanical properties.
Flowability should be also evaluated, since it affects sample processability. Additionally, particle
size and shape, material density and compressibility, compactibility and tabletability profiles have
been also distinguished as relevant properties for solid dosage form development.
The application of mathematical approaches may contribute to the mechanistic
understanding of critical material attributes and facilitate dosage form development and
optimization. However, it is essential to select the appropriate one, based on the intended dosage
form characteristics, in order to ensure that all relevant powder/multiparticulate units
characteristics are implemented and critically evaluated.
AB  - Poznavanje uticaja svojstava materijala i procesnih parametara na karakteristike čvrstih farmaceutskih oblika predstavlja osnovu Quality-by-design pristupa razvoju lekova. Kako bi bio olakšan razvoj formulacije i izbor proizvodne tehnologije, više istraživačkih grupa opisalo je matematičke pristupe, koji se zasnivaju na čestičnim karakteristikama čestica, osobinama praška i ponašanju materijala pri kompresiji. U ovom radu prikazana su teorijska razmatranja i kritički pregled matematičkih pristupa razvijenih za karakterizaciju praškova i višečestičnih sistema. Ovi matematički pristupi su, generalno, razvijeni za karakterizaciju materijala pogodnih za direktnu kompresiju. Međutim, u nekim slučajevima se razmatraju i druge tehnologije, kao što su suva i vlažna granulacija. Među opisanim karakteristikama materijala, zatezna čvrstina se izdvaja kao jedna od najznačajnijih za procenu mehaničkih svojstava kompakta. Potrebno je ispitati i protočnost materijala. Takođe, veličina i oblik čestica, gustina materijala i profili koji opisuju kompresibilnost, kompaktibilnost i tabletabilnost materijala prepoznati su kao karakteristike koje značajno utiču na razvoj čvrstih farmaceutskih oblika. Primena matematičkih pristupa u karakterizaciji praškova i višečestičnih sistema može doprineti mehanističkom razumevanju svojstava materijala i olakšati razvoj i optimizaciju čvrstih farmaceutskih oblika lekova. Međutim, ključno je odabrati odgovarajući pristup, zavisno od željenih karakteristika finalnog preparata, kako bi sva kritična svojstva materijala bila ispitana i kritički razmotrena.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development
T1  - Pregled i kritička analiza matematičkih pristupa za karakterizaciju praškova i višečestičnih sistema u razvoju lekova
VL  - 72
IS  - 6
SP  - 637
EP  - 660
DO  - 10.5937/arhfarm72-40961
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Parojčić, Jelena",
year = "2022",
abstract = "An understanding of material properties and processing effects on solid dosage forms
performance is required within the Quality-by-design approach to pharmaceutical development.
Several research groups have developed mathematical approaches aiming to facilitate the
selection of formulation composition and the manufacturing technology. These approaches are
based on material particulate, bulk and compression-related properties. This paper provides
theoretical assumptions and a critical review of different mathematical approaches for
processability characterization of powders and multiparticulate units.
Mathematical approaches have mainly been developed for directly compressible materials,
but sometimes other manufacturing technologies, such as roller compaction and wet granulation,
are also considered. The obtained compact tensile strength has been implemented in the majority
of approaches, as an important characteristic describing compact mechanical properties.
Flowability should be also evaluated, since it affects sample processability. Additionally, particle
size and shape, material density and compressibility, compactibility and tabletability profiles have
been also distinguished as relevant properties for solid dosage form development.
The application of mathematical approaches may contribute to the mechanistic
understanding of critical material attributes and facilitate dosage form development and
optimization. However, it is essential to select the appropriate one, based on the intended dosage
form characteristics, in order to ensure that all relevant powder/multiparticulate units
characteristics are implemented and critically evaluated., Poznavanje uticaja svojstava materijala i procesnih parametara na karakteristike čvrstih farmaceutskih oblika predstavlja osnovu Quality-by-design pristupa razvoju lekova. Kako bi bio olakšan razvoj formulacije i izbor proizvodne tehnologije, više istraživačkih grupa opisalo je matematičke pristupe, koji se zasnivaju na čestičnim karakteristikama čestica, osobinama praška i ponašanju materijala pri kompresiji. U ovom radu prikazana su teorijska razmatranja i kritički pregled matematičkih pristupa razvijenih za karakterizaciju praškova i višečestičnih sistema. Ovi matematički pristupi su, generalno, razvijeni za karakterizaciju materijala pogodnih za direktnu kompresiju. Međutim, u nekim slučajevima se razmatraju i druge tehnologije, kao što su suva i vlažna granulacija. Među opisanim karakteristikama materijala, zatezna čvrstina se izdvaja kao jedna od najznačajnijih za procenu mehaničkih svojstava kompakta. Potrebno je ispitati i protočnost materijala. Takođe, veličina i oblik čestica, gustina materijala i profili koji opisuju kompresibilnost, kompaktibilnost i tabletabilnost materijala prepoznati su kao karakteristike koje značajno utiču na razvoj čvrstih farmaceutskih oblika. Primena matematičkih pristupa u karakterizaciji praškova i višečestičnih sistema može doprineti mehanističkom razumevanju svojstava materijala i olakšati razvoj i optimizaciju čvrstih farmaceutskih oblika lekova. Međutim, ključno je odabrati odgovarajući pristup, zavisno od željenih karakteristika finalnog preparata, kako bi sva kritična svojstva materijala bila ispitana i kritički razmotrena.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development, Pregled i kritička analiza matematičkih pristupa za karakterizaciju praškova i višečestičnih sistema u razvoju lekova",
volume = "72",
number = "6",
pages = "637-660",
doi = "10.5937/arhfarm72-40961"
}

Vasiljević, I., Turković, E., Aleksić, I.,& Parojčić, J.. (2022). Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 637-660.
https://doi.org/10.5937/arhfarm72-40961

Vasiljević I, Turković E, Aleksić I, Parojčić J. Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development. in Arhiv za farmaciju. 2022;72(6):637-660.
doi:10.5937/arhfarm72-40961 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Parojčić, Jelena, "Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development" in Arhiv za farmaciju, 72, no. 6 (2022):637-660,
https://doi.org/10.5937/arhfarm72-40961 . .

TY  - CONF
AU  - Aleksić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4465
AB  - Increasing number of poorly water-soluble drugs poses the great challenges in
formulation development of solid dosage forms. To overcome bioavailability issues
numerous approaches have been developed during last decades. Most of the commonly
applied methods are associated with the use of complex and/or energy consuming
technological processes (e.g. different techniques for preparation of solid dispersions). From
the late 1990s the idea of converting drug solution/suspension into dry-looking powder has
evolved from “powdered solution technology” to liquisolid systems as a simpler, greener
process requiring lower production costs in comparison with commonly used approaches
for bioavailability enhancement (1). Liquisolid technology considers conversion of drug
dispersion (preferably solution) in non-volatile, hydrophilic liquid vehicle into the powder
that is not only free flowing, but also possess acceptable compaction properties required for
tableting or capsule filling. Development of novel, highly porous excipients has further
increased research interest and possibility for wider use of this technique. Numerous studies
have demonstrated the potential of this emerging technique to enhance in vitro dissolution
rate, and some studies have also confirmed improved bioavailability of various poorly water-
soluble drugs from liquisolid formulations. Furthermore, this promising technique has been
investigated as an approach to prepare orally disintegrating tablets, modified release
preparations, as well as solid dosage forms with liquid herbal extracts. Recent studies
address the lack of knowledge regarding compaction behavior of these systems and the need
for new solutions to overcome limitations related to application of this technology in the
case of high-dose drugs.
AB  - Sve je više lekovitih supstanci koje su slabo rastvorljive u vodi što predstavlja veliki
izazov u razvoju formulacija čvrstih farmaceutskih oblika lekova. U cilju prevazilaženja
problema vezanih za nisku biološku raspoloživost, tokom poslednjih decenija razvijeni su
brojni pristupi. Većina ovih metoda podrazumeva primenu složenih i/ili energetski
zahtevnih tehnoloških procesa (npr. različite tehnike za izradu čvrstih disperzija). Od kraja
1990-tih godina ideja o prevođenju rastvora/suspenzije lekovite supstance u prašak suvog
izgleda razvijana је od pristupa pod nazivom “powdered solution technology” do tečno-
čvrstih sistema (engl. liquisolid systems) kao jednostavnijeg, ekonomičnijeg i ekološki
prihvatljivijeg postupka u poređenju sa uobičajeno primenjivanim metodama za poboljšanje
biološke raspoloživosti (1). Izrada tečno-čvrstih sistema podrazumeva prevođenje disperzije
lekovite supstance (poželjno rastvora) u neisparljivom, hidrofilnom, tečnom vehikulumu u
prašak koji, pored dobre protočnosti, ima i prihvatljiva svojstva pri kompresiji, koja su
neophodna za izradu tableta ili kapsula. Razvoj novih, visokoporoznih ekscipijenasa je
dodatno povećao interesovanje istraživača i mogućnost za širu primenu ove tehnike. Brojna
istraživanja su pokazala potencijal ove nove metode da poveća in vitro brzinu rastvaranja, a
neke studije su potvrdile i poboljšanu biološku raspoloživost različitih slabo rastvorljivih
lekovitih supstanci iz tečno-čvrstih formulacija. Dodatno, ispitivana je mogućnost primene
ove metode kao pristupa za izradu oralno-disperzibilnih tableta, preparata sa modifikovanim
oslobađanjem, kao i čvrstih farmaceutskih oblika sa tečnim biljnim ekstraktima. Nedavna
istraživanja se odnose na ispitivanje ponašanja ovih sistema pri kompresiji o čemu do sada
nema dovoljno znanja, kao i na pronalaženje novih rešenja kako bi se prevazišla ograničenja
vezana za primenu ove tehnologije u slučaju visokodoziranih lekovitih supstanci.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Liquisolid systems: From formulation development challenges to improved bioavailability
T1  - Tečno‐čvrsti sistemi: od izazova u razvoju formulacije do poboljšane biološke raspoloživosti
VL  - 72
IS  - 4 suplement
SP  - S117
EP  - S118
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4465
ER  - 

@conference{
author = "Aleksić, Ivana",
year = "2022",
abstract = "Increasing number of poorly water-soluble drugs poses the great challenges in
formulation development of solid dosage forms. To overcome bioavailability issues
numerous approaches have been developed during last decades. Most of the commonly
applied methods are associated with the use of complex and/or energy consuming
technological processes (e.g. different techniques for preparation of solid dispersions). From
the late 1990s the idea of converting drug solution/suspension into dry-looking powder has
evolved from “powdered solution technology” to liquisolid systems as a simpler, greener
process requiring lower production costs in comparison with commonly used approaches
for bioavailability enhancement (1). Liquisolid technology considers conversion of drug
dispersion (preferably solution) in non-volatile, hydrophilic liquid vehicle into the powder
that is not only free flowing, but also possess acceptable compaction properties required for
tableting or capsule filling. Development of novel, highly porous excipients has further
increased research interest and possibility for wider use of this technique. Numerous studies
have demonstrated the potential of this emerging technique to enhance in vitro dissolution
rate, and some studies have also confirmed improved bioavailability of various poorly water-
soluble drugs from liquisolid formulations. Furthermore, this promising technique has been
investigated as an approach to prepare orally disintegrating tablets, modified release
preparations, as well as solid dosage forms with liquid herbal extracts. Recent studies
address the lack of knowledge regarding compaction behavior of these systems and the need
for new solutions to overcome limitations related to application of this technology in the
case of high-dose drugs., Sve je više lekovitih supstanci koje su slabo rastvorljive u vodi što predstavlja veliki
izazov u razvoju formulacija čvrstih farmaceutskih oblika lekova. U cilju prevazilaženja
problema vezanih za nisku biološku raspoloživost, tokom poslednjih decenija razvijeni su
brojni pristupi. Većina ovih metoda podrazumeva primenu složenih i/ili energetski
zahtevnih tehnoloških procesa (npr. različite tehnike za izradu čvrstih disperzija). Od kraja
1990-tih godina ideja o prevođenju rastvora/suspenzije lekovite supstance u prašak suvog
izgleda razvijana је od pristupa pod nazivom “powdered solution technology” do tečno-
čvrstih sistema (engl. liquisolid systems) kao jednostavnijeg, ekonomičnijeg i ekološki
prihvatljivijeg postupka u poređenju sa uobičajeno primenjivanim metodama za poboljšanje
biološke raspoloživosti (1). Izrada tečno-čvrstih sistema podrazumeva prevođenje disperzije
lekovite supstance (poželjno rastvora) u neisparljivom, hidrofilnom, tečnom vehikulumu u
prašak koji, pored dobre protočnosti, ima i prihvatljiva svojstva pri kompresiji, koja su
neophodna za izradu tableta ili kapsula. Razvoj novih, visokoporoznih ekscipijenasa je
dodatno povećao interesovanje istraživača i mogućnost za širu primenu ove tehnike. Brojna
istraživanja su pokazala potencijal ove nove metode da poveća in vitro brzinu rastvaranja, a
neke studije su potvrdile i poboljšanu biološku raspoloživost različitih slabo rastvorljivih
lekovitih supstanci iz tečno-čvrstih formulacija. Dodatno, ispitivana je mogućnost primene
ove metode kao pristupa za izradu oralno-disperzibilnih tableta, preparata sa modifikovanim
oslobađanjem, kao i čvrstih farmaceutskih oblika sa tečnim biljnim ekstraktima. Nedavna
istraživanja se odnose na ispitivanje ponašanja ovih sistema pri kompresiji o čemu do sada
nema dovoljno znanja, kao i na pronalaženje novih rešenja kako bi se prevazišla ograničenja
vezana za primenu ove tehnologije u slučaju visokodoziranih lekovitih supstanci.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Liquisolid systems: From formulation development challenges to improved bioavailability, Tečno‐čvrsti sistemi: od izazova u razvoju formulacije do poboljšane biološke raspoloživosti",
volume = "72",
number = "4 suplement",
pages = "S117-S118",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4465"
}

Aleksić, I.. (2022). Liquisolid systems: From formulation development challenges to improved bioavailability. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S117-S118.
https://hdl.handle.net/21.15107/rcub_farfar_4465

Aleksić I. Liquisolid systems: From formulation development challenges to improved bioavailability. in Arhiv za farmaciju. 2022;72(4 suplement):S117-S118.
https://hdl.handle.net/21.15107/rcub_farfar_4465 .

Aleksić, Ivana, "Liquisolid systems: From formulation development challenges to improved bioavailability" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S117-S118,
https://hdl.handle.net/21.15107/rcub_farfar_4465 .

TY  - CONF
AU  - Glišić, Teodora
AU  - Petrović, Jovana
AU  - Cvijić, Sandra
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5525
AB  - Development of novel porous excipients with high specific surface area enabled formulation of
liquisolid systems with considerably increased content of liquid drug (or drug solution/suspension)
in comparison to those prepared with commonly used carriers, such as microcrystalline cellulose,
while ensuring good flowability.  ...
PB  - Medical University of Gdansk
PB  - Polskie Towarzystwo Farmaceutyczne
C3  - Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
T1  - Dynamic compaction analysis of liquisolid systems with magnesium aluminometasilicate as carrier
SP  - 114
EP  - 115
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5525
ER  - 

@conference{
author = "Glišić, Teodora and Petrović, Jovana and Cvijić, Sandra and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Development of novel porous excipients with high specific surface area enabled formulation of
liquisolid systems with considerably increased content of liquid drug (or drug solution/suspension)
in comparison to those prepared with commonly used carriers, such as microcrystalline cellulose,
while ensuring good flowability.  ...",
publisher = "Medical University of Gdansk, Polskie Towarzystwo Farmaceutyczne",
journal = "Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland",
title = "Dynamic compaction analysis of liquisolid systems with magnesium aluminometasilicate as carrier",
pages = "114-115",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5525"
}

Glišić, T., Petrović, J., Cvijić, S., Parojčić, J.,& Aleksić, I.. (2021). Dynamic compaction analysis of liquisolid systems with magnesium aluminometasilicate as carrier. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
Medical University of Gdansk., 114-115.
https://hdl.handle.net/21.15107/rcub_farfar_5525

Glišić T, Petrović J, Cvijić S, Parojčić J, Aleksić I. Dynamic compaction analysis of liquisolid systems with magnesium aluminometasilicate as carrier. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland. 2021;:114-115.
https://hdl.handle.net/21.15107/rcub_farfar_5525 .

Glišić, Teodora, Petrović, Jovana, Cvijić, Sandra, Parojčić, Jelena, Aleksić, Ivana, "Dynamic compaction analysis of liquisolid systems with magnesium aluminometasilicate as carrier" in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland (2021):114-115,
https://hdl.handle.net/21.15107/rcub_farfar_5525 .

TY  - CONF
AU  - Glišić, Teodora
AU  - Vlatković, Milica
AU  - Boričić, Anica
AU  - Bjelobrk, Jelena
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4672
AB  - The use of herbal preparations and preparations based on bee products is
increasingly present in modern therapy, but the number of solid dosage forms with these
active principles present on the market is relatively small (1). Liquisolid systems are
formulations where liquid medication is converted into powder with good flowability,
compressibility and compactibility, using selected excipients. This simple and energy
efficient process could find application in the production of solid dosage forms with liquid
extracts, which would contribute to overcoming some of the challenges associated with the
use of these preparations, such as imprecise dosing, unpleasant taste and ease of application
for patients (2). The aim of this study was to examine the influence of carrier type on
flowability, tabletability, disintegration and wettability of liquisolid compacts prepared with
natural liquid extracts.
Syloid ® XDP 3050, Neusilin® US2, Fujicalin® and Vivapur® type 101 were used as
carriers, and colloidal silicon dioxide as a coating agent. St. John's wort oil extract and
propylene glycol extract of propolis were used as the liquid phase. The admixtures were
prepared using mortar and pestle, concentration of liquid phase ranged between 15.4% and
49.8%. Flowability was examined by three different methods. Compaction properties were
tested after compression on an eccentric tablet machine and compaction analyser.
Disintegration time and wetting properties were investigated, as well.
The admixtures containing St. John's wort oil extract showed good flowability
regardless of the carrier used. Admixtures containing propolis extract showed fair
flowability, except the admixture with Neusilin ® US2 as a carrier which, despite the high
liquid load, showed good flowability. Acceptable tensile strength was achieved in all
compacts compressed using compaction analyser. The influence of formulation factors (type
of carrier, type and concentration of liquid phase) on wettability of liquisolid compacts was
observed. The shortest wetting time was achieved with microcrystalline cellulose, in
compacts with St. John's wort oil extract, and Fujicalin® , in compacts with propylene glycol
extract of propolis, respectively. In both cases, the highest water absorption ratio was
achieved with microcrystalline cellulose as a carrier. Liquisolid compacts with propylene
glycol extract of propolis and Fujicalin® showed satisfactory disintegration time, while the
addition of a superdisintegrant would be necessary for all the other formulations.
The obtained results indicate a significant potential for the application of highly
porous carriers and liquisolid technology as an approach to convert liquid preparations with
natural active principles into tablets, a dosage form widely accepted by patients.
AB  - Primena biljnih preparata i preparata na bazi pčelinjih proizvoda sve je više
zastupljena u savremenoj terapiji, ali je na tržištu prisutan mali broj čvrstih farmaceutskih
oblika sa ovim aktivnim principima (1). Tečno-čvrsti sistemi (engl. liquisolid systems)
predstavljaju formulacije kod kojih se primenom odabranih ekscipijenasa aktivna supstanca
u tečnom obliku ili njen rastvor/disperzija prevodi u prašak dobre protočnosti,
kompresibilnosti i kompaktibilnosti. Ovaj jednostavan i energetski efikasan postupak bi
mogao naći primenu u proizvodnji čvrstih farmaceutskih oblika sa tečnim ekstraktima, što bi
doprinelo prevazilaženju nekih od izazova povezanih sa primenom ovih preparata kao što su
neprecizno doziranje, neprijatan ukus i jednostavnost primene za pacijente (2). Cilj ovog
rada bio je da se ispita uticaj vrste nosača na protočnost, tabletabilnost, raspadljivost i
sposobnost kvašenja tečno-čvrstih kompakata pripremljenih sa tečnim ekstraktima
prirodnog porekla.
Porozni ekscipijensi Syloid® XDP 3050, Neusilin® US2, Fujicalin® i Vivapur ® type 101
korišćeni su kao nosači, a koloidni silicijum-dioksid kao sredstvo za oblaganje. Kao tečna faza
korišćeni su biljni preparat na bazi uljanog ekstrakta kantariona i propilenglikolni ekstrakt
propolisa. Smeše su pripremljene pomoću tarionika i pistila, udeo tečne faze kretao se od
15,4% до 49,8%. Protočnost pripremljenih smeša ispitana je primenom tri različite metode.
Svojstva pri kompresiji ispitana su nakon komprimovanja na ekscentar tablet mašini i
simulatoru kompakcije, a zatim su ispitane raspadljivost i sposobnost kvašenja kompakata.
Sve smeše pripremljene sa uljanim ekstraktom kantariona pokazale su dobru
protočnost nezavisno od primenjenog nosača. Smeše pripremljene sa ekstraktom propolisa
pokazale su umerenu protočnost, osim smeše sa Neusilin® US2 kao nosačem koja je i pored
visokog udela tečne faze pokazala dobru protočnost. Zadovoljavajuća zatezna čvrstina
postignuta je kod svih kompakata izrađenih na simulatoru kompakcije. Uočen je uticaj
faktora formulacije (vrsta nosača, vrsta i udeo tečne faze) na sposobnost kvašenja tečno-
čvrstih kompakata. Najkraće vreme kvašenja postignuto je kada je kao nosač korišćena
mikrokristalna celuloza, kod kompakata sa uljanim ekstraktom kantariona, odnosno
Fujicalin® , kod kompakata sa propilenglikolnim ekstraktom propolisa. U oba slučaja najveći
stepen apsorpcije vode postignut je sa mikrokristalnom celulozom kao nosačem.
Ispitivanjem raspadljivosti utvrđeno je da tečno-čvrsti kompakti sa propilenglikolnim
ekstraktom propolisa i Fujicalin®-om kao nosačem pokazuju zadovoljavajuću raspadljivost,
dok je za sve druge formulacije neophodan dodatak superdezintegratora.
Dobijeni rezultati ukazuju na značajan potencijal primene visoko poroznih nosača i
tehnologije tečno-čvrstih sistema kao pristupa za prevođenje tečnih preparata sa aktivnim
principima prirodnog porekla u tablete, kao farmaceutski oblik koji je široko prihvaćen od
strane pacijenata.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Investigation into the influence of carrier type on characteristics of liquisolid compacts prepared with natural active principles
T1  - Ispitivanje uticaja vrste nosača na svojstva tečno‐čvrstih kompakata sa aktivnim principima prirodnog porekla
VL  - 71
IS  - 5 suplement
SP  - S82
EP  - S85
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4672
ER  - 

@conference{
author = "Glišić, Teodora and Vlatković, Milica and Boričić, Anica and Bjelobrk, Jelena and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "The use of herbal preparations and preparations based on bee products is
increasingly present in modern therapy, but the number of solid dosage forms with these
active principles present on the market is relatively small (1). Liquisolid systems are
formulations where liquid medication is converted into powder with good flowability,
compressibility and compactibility, using selected excipients. This simple and energy
efficient process could find application in the production of solid dosage forms with liquid
extracts, which would contribute to overcoming some of the challenges associated with the
use of these preparations, such as imprecise dosing, unpleasant taste and ease of application
for patients (2). The aim of this study was to examine the influence of carrier type on
flowability, tabletability, disintegration and wettability of liquisolid compacts prepared with
natural liquid extracts.
Syloid ® XDP 3050, Neusilin® US2, Fujicalin® and Vivapur® type 101 were used as
carriers, and colloidal silicon dioxide as a coating agent. St. John's wort oil extract and
propylene glycol extract of propolis were used as the liquid phase. The admixtures were
prepared using mortar and pestle, concentration of liquid phase ranged between 15.4% and
49.8%. Flowability was examined by three different methods. Compaction properties were
tested after compression on an eccentric tablet machine and compaction analyser.
Disintegration time and wetting properties were investigated, as well.
The admixtures containing St. John's wort oil extract showed good flowability
regardless of the carrier used. Admixtures containing propolis extract showed fair
flowability, except the admixture with Neusilin ® US2 as a carrier which, despite the high
liquid load, showed good flowability. Acceptable tensile strength was achieved in all
compacts compressed using compaction analyser. The influence of formulation factors (type
of carrier, type and concentration of liquid phase) on wettability of liquisolid compacts was
observed. The shortest wetting time was achieved with microcrystalline cellulose, in
compacts with St. John's wort oil extract, and Fujicalin® , in compacts with propylene glycol
extract of propolis, respectively. In both cases, the highest water absorption ratio was
achieved with microcrystalline cellulose as a carrier. Liquisolid compacts with propylene
glycol extract of propolis and Fujicalin® showed satisfactory disintegration time, while the
addition of a superdisintegrant would be necessary for all the other formulations.
The obtained results indicate a significant potential for the application of highly
porous carriers and liquisolid technology as an approach to convert liquid preparations with
natural active principles into tablets, a dosage form widely accepted by patients., Primena biljnih preparata i preparata na bazi pčelinjih proizvoda sve je više
zastupljena u savremenoj terapiji, ali je na tržištu prisutan mali broj čvrstih farmaceutskih
oblika sa ovim aktivnim principima (1). Tečno-čvrsti sistemi (engl. liquisolid systems)
predstavljaju formulacije kod kojih se primenom odabranih ekscipijenasa aktivna supstanca
u tečnom obliku ili njen rastvor/disperzija prevodi u prašak dobre protočnosti,
kompresibilnosti i kompaktibilnosti. Ovaj jednostavan i energetski efikasan postupak bi
mogao naći primenu u proizvodnji čvrstih farmaceutskih oblika sa tečnim ekstraktima, što bi
doprinelo prevazilaženju nekih od izazova povezanih sa primenom ovih preparata kao što su
neprecizno doziranje, neprijatan ukus i jednostavnost primene za pacijente (2). Cilj ovog
rada bio je da se ispita uticaj vrste nosača na protočnost, tabletabilnost, raspadljivost i
sposobnost kvašenja tečno-čvrstih kompakata pripremljenih sa tečnim ekstraktima
prirodnog porekla.
Porozni ekscipijensi Syloid® XDP 3050, Neusilin® US2, Fujicalin® i Vivapur ® type 101
korišćeni su kao nosači, a koloidni silicijum-dioksid kao sredstvo za oblaganje. Kao tečna faza
korišćeni su biljni preparat na bazi uljanog ekstrakta kantariona i propilenglikolni ekstrakt
propolisa. Smeše su pripremljene pomoću tarionika i pistila, udeo tečne faze kretao se od
15,4% до 49,8%. Protočnost pripremljenih smeša ispitana je primenom tri različite metode.
Svojstva pri kompresiji ispitana su nakon komprimovanja na ekscentar tablet mašini i
simulatoru kompakcije, a zatim su ispitane raspadljivost i sposobnost kvašenja kompakata.
Sve smeše pripremljene sa uljanim ekstraktom kantariona pokazale su dobru
protočnost nezavisno od primenjenog nosača. Smeše pripremljene sa ekstraktom propolisa
pokazale su umerenu protočnost, osim smeše sa Neusilin® US2 kao nosačem koja je i pored
visokog udela tečne faze pokazala dobru protočnost. Zadovoljavajuća zatezna čvrstina
postignuta je kod svih kompakata izrađenih na simulatoru kompakcije. Uočen je uticaj
faktora formulacije (vrsta nosača, vrsta i udeo tečne faze) na sposobnost kvašenja tečno-
čvrstih kompakata. Najkraće vreme kvašenja postignuto je kada je kao nosač korišćena
mikrokristalna celuloza, kod kompakata sa uljanim ekstraktom kantariona, odnosno
Fujicalin® , kod kompakata sa propilenglikolnim ekstraktom propolisa. U oba slučaja najveći
stepen apsorpcije vode postignut je sa mikrokristalnom celulozom kao nosačem.
Ispitivanjem raspadljivosti utvrđeno je da tečno-čvrsti kompakti sa propilenglikolnim
ekstraktom propolisa i Fujicalin®-om kao nosačem pokazuju zadovoljavajuću raspadljivost,
dok je za sve druge formulacije neophodan dodatak superdezintegratora.
Dobijeni rezultati ukazuju na značajan potencijal primene visoko poroznih nosača i
tehnologije tečno-čvrstih sistema kao pristupa za prevođenje tečnih preparata sa aktivnim
principima prirodnog porekla u tablete, kao farmaceutski oblik koji je široko prihvaćen od
strane pacijenata.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Investigation into the influence of carrier type on characteristics of liquisolid compacts prepared with natural active principles, Ispitivanje uticaja vrste nosača na svojstva tečno‐čvrstih kompakata sa aktivnim principima prirodnog porekla",
volume = "71",
number = "5 suplement",
pages = "S82-S85",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4672"
}

Glišić, T., Vlatković, M., Boričić, A., Bjelobrk, J., Parojčić, J.,& Aleksić, I.. (2021). Investigation into the influence of carrier type on characteristics of liquisolid compacts prepared with natural active principles. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S82-S85.
https://hdl.handle.net/21.15107/rcub_farfar_4672

Glišić T, Vlatković M, Boričić A, Bjelobrk J, Parojčić J, Aleksić I. Investigation into the influence of carrier type on characteristics of liquisolid compacts prepared with natural active principles. in Arhiv za farmaciju. 2021;71(5 suplement):S82-S85.
https://hdl.handle.net/21.15107/rcub_farfar_4672 .

Glišić, Teodora, Vlatković, Milica, Boričić, Anica, Bjelobrk, Jelena, Parojčić, Jelena, Aleksić, Ivana, "Investigation into the influence of carrier type on characteristics of liquisolid compacts prepared with natural active principles" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S82-S85,
https://hdl.handle.net/21.15107/rcub_farfar_4672 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - German Ilić, Ilija
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5315
AB  - Software assisted image analysis represents emerging approach, which may provide useful insight
into sample properties [1]. However, its application in the pharmaceutical field is scarce. The aim of
this work was to investigate the applicability of software assisted porosity evaluation in liquisolid
pellets characterization. ...
PB  - Medical University of Gdansk
PB  - Polskie Towarzystwo Farmaceutyczne
C3  - Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
T1  - Applicability of software assisted porosity evaluation in liquisolid pellets characterization
SP  - 75
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5315
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and German Ilić, Ilija and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Software assisted image analysis represents emerging approach, which may provide useful insight
into sample properties [1]. However, its application in the pharmaceutical field is scarce. The aim of
this work was to investigate the applicability of software assisted porosity evaluation in liquisolid
pellets characterization. ...",
publisher = "Medical University of Gdansk, Polskie Towarzystwo Farmaceutyczne",
journal = "Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland",
title = "Applicability of software assisted porosity evaluation in liquisolid pellets characterization",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5315"
}

Vasiljević, I., Turković, E., German Ilić, I., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Applicability of software assisted porosity evaluation in liquisolid pellets characterization. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
Medical University of Gdansk., 75-75.
https://hdl.handle.net/21.15107/rcub_farfar_5315

Vasiljević I, Turković E, German Ilić I, Zimmer A, Parojčić J, Aleksić I. Applicability of software assisted porosity evaluation in liquisolid pellets characterization. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland. 2021;:75-75.
https://hdl.handle.net/21.15107/rcub_farfar_5315 .

Vasiljević, Ivana, Turković, Erna, German Ilić, Ilija, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Applicability of software assisted porosity evaluation in liquisolid pellets characterization" in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland (2021):75-75,
https://hdl.handle.net/21.15107/rcub_farfar_5315 .

TY  - CONF
AU  - Ćirin-Varađan, Slobodanka
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4671
AB  - The lack of directly compressible excipients and the introduction of the high-speed
manufacturing machines have further increased the interest in the development of co-processed
excipients. In the present study, in situ fluidized bed melt granulation (FBMG) as an environmental
friendly and cost-effective method, was applied to co-process the most common filler, lactose
monohydrate, with lipid excipients glyceryl dibehenate (Compritol ® 888 ATO) or glyceryl
palmitostearate (Precirol ® ATO 5) known for their antiadhesive, lubricant and flowing aid properties
(1, 2). The goal of this study was to develop the lipid-based co-processed excipients and to investigate
their flowability and tableting properties using a solvent-free and eco-friendly, FBMG method.
The flow properties of the tested samples (the single-component excipients, their physical
mixtures, lactose (85% (w/w)) co-processed with Precirol® or Compritol ® (15% (w/w)), and
commercially available lactose-based co-processed excipients (Retalac ® and Ludipress®) were
evaluated by Carr index and Hausner ratio. Dynamic compaction analysis of the investigated excipients
was performed on a single punch instrumented tablet press (GTP D series, Gamlen Tableting Ltd, UK).
Comparable or even better flowability of co-processed excipients obtained via in situ FBMG, in
comparison to commercial co-processed excipients indicate their suitability for direct compression. Co-
processed excipients with Precirol ® and Compritol ®, as well as the corresponding physical mixtures,
showed two to almost three times lower values of total work of compression than those obtained for
commercial lactose-based excipients. Furthermore, co-processed excipients prepared with lipid
excipients showed up to 50-fold lower detachment work and up to 20-fold lower ejection work than
those obtained for Retalac ® and Ludipress®. Superior antiadhesive and lubricating properties of the
excipients prepared by in situ FBMG can be attributed to the properties of lipid excipients. Both
commercially available and the investigated co-processed excipients, prepared with lipid excipients,
showed relatively high tensile strength values (>1.7 MPa).
The results presented in this study indicate that in situ fluidized bed melt granulation can be
used as suitable co-processing technique, as a time and energy less consuming method in comparison
with commonly applied techniques such as spray drying and wet granulation. According to the results
obtained, by co-processing lactose with selected lipid excipients excellent flowability, as well as
improved tableting properties can be achieved. Novel co-processed excipients were even found to be
highly superior regarding their antiadhesive and lubricating properties in comparison to commercial
lactose-based co-processed excipients.
AB  - Nedostatak direktno kompresibilnih ekscipijenasa i uvođenje proizvodne opreme velike brzine
rada dodatno su povećali interesovanje za razvoj koprocesovanih ekscipijenasa. U ovoj studiji, in situ
granulacija topljenjem u uređaju tipa fluidizirajućeg sistema (eng. fluidized bed melt granulation,
FBMG), kao ekološki prihvatljiva i ekonomična metoda, primenjena je za koprocesovanje najčešće
korišćenog sredstva za dopunjavanje, laktoze, monohidrata, sa lipidnim ekscipijensima,
glicerildibehenatom (Compritol® 888 ATO) ili glicerilpalmitostearatom (Precirol® ATO 5), koji su
poznati po svojim antiadhezivnim, lubrikatnim i protočnim osobinama (1, 2). Cilj ovog ispitivanja je bio
razvoj novih koprocesovanih ekscipijenasa na bazi lipida primenom ekološki prihvatljive metode, koja
ne zahteva upotrebu rastvarača, i ispitivanje njihove protočnosti i tabletabilnosti.
Protočne karakteristike ispitivanih uzoraka (pojedinačni ekscipijensi, njihove fizičke smeše,
laktoza ((85% (m/m)) koprocesovana sa Precirol ®-om ili Compritol®-om (15% (m/m)), i komercijalno
dostupni koprocesovani ekscipijensi na bazi laktoze (Retalac ® i Ludipress® )) procenjene su na osnovu
vrednosti Carr-ovog indeksa i Hausner‐ovog odnosa. Laboratorijski simulator kompakcije (GTP D serija,
Gamlen Tableting Ltd, UK) korišćen je za dinamičku analizu kompakcije.
Uporedive ili čak bolje protočne karakteristike koprocesovanih ekscipijensa dobijenih metodom
in situ FBMG, u poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima, ukazuju na
njihovu podobnost za direktnu kompresiju. Koprocesovani ekscipijensi sa Precirol®-om i Compritol ®-
om, kao i odgovarajuće fizičke smeše, pokazale su dva do skoro tri puta niže vrednosti ukupnog rada
kompresije od komercijalno dostupnih ekscipijenasa na bazi laktoze. Dodatno, koprocesovani
ekscipijensi na bazi lipida pokazali su do 50 puta manji rad odvajanja i do 20 puta manji rad izbacivanja
od Retalac ®-a i Ludipress® -a. Superiorna antiadhezivna i lubrikatna svojstva koprocesovanih
ekscipijenasa pripremljenih in situ FBMG mogu se pripisati lipidnim ekscipijensima. Komercijalno
dostupni kao i ispitivani koprocesovani ekscipijensi, na bazi lipidnih ekscipijenasa, pokazali su
relativno visoke vrednosti zatezne čvrstine (> 1,7 MPa).
Predstavljeni rezultati ukazuju na to da se granulacija topljenjem u uređaju tipa fluidizirajućeg
sistema može koristiti kao pogodna metoda za koprocesovanje, koja zahteva manji utrošak energije i
vremena u poređenju sa uobičajenim tehnikama, poput sušenja raspršivanjem ili vlažne granulacije.
Dobijeni rezultati pokazuju da se koprocesovanjem laktoze sa odabranim lipidnim ekscipijensima može
postići odlična protočnost, kao i poboljšana tabletabilnost. Novi koprocesovani ekscipijensi su čak
pokazali superiornije karakteristike u pogledu svojih antiadhezivnih i lubrikatnih karakteristika u
poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima na bazi laktoze.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Application of solventless granulation method for developent of novel co‐processed excipeints
T1  - Primena metode granulacije bez upotrebe rastvarača u razvoju novih koprocesovanih ekscipijenasa
VL  - 71
IS  - 5 suplement
SP  - S80
EP  - S81
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4671
ER  - 

@conference{
author = "Ćirin-Varađan, Slobodanka and Đuriš, Jelena and Ibrić, Svetlana and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "The lack of directly compressible excipients and the introduction of the high-speed
manufacturing machines have further increased the interest in the development of co-processed
excipients. In the present study, in situ fluidized bed melt granulation (FBMG) as an environmental
friendly and cost-effective method, was applied to co-process the most common filler, lactose
monohydrate, with lipid excipients glyceryl dibehenate (Compritol ® 888 ATO) or glyceryl
palmitostearate (Precirol ® ATO 5) known for their antiadhesive, lubricant and flowing aid properties
(1, 2). The goal of this study was to develop the lipid-based co-processed excipients and to investigate
their flowability and tableting properties using a solvent-free and eco-friendly, FBMG method.
The flow properties of the tested samples (the single-component excipients, their physical
mixtures, lactose (85% (w/w)) co-processed with Precirol® or Compritol ® (15% (w/w)), and
commercially available lactose-based co-processed excipients (Retalac ® and Ludipress®) were
evaluated by Carr index and Hausner ratio. Dynamic compaction analysis of the investigated excipients
was performed on a single punch instrumented tablet press (GTP D series, Gamlen Tableting Ltd, UK).
Comparable or even better flowability of co-processed excipients obtained via in situ FBMG, in
comparison to commercial co-processed excipients indicate their suitability for direct compression. Co-
processed excipients with Precirol ® and Compritol ®, as well as the corresponding physical mixtures,
showed two to almost three times lower values of total work of compression than those obtained for
commercial lactose-based excipients. Furthermore, co-processed excipients prepared with lipid
excipients showed up to 50-fold lower detachment work and up to 20-fold lower ejection work than
those obtained for Retalac ® and Ludipress®. Superior antiadhesive and lubricating properties of the
excipients prepared by in situ FBMG can be attributed to the properties of lipid excipients. Both
commercially available and the investigated co-processed excipients, prepared with lipid excipients,
showed relatively high tensile strength values (>1.7 MPa).
The results presented in this study indicate that in situ fluidized bed melt granulation can be
used as suitable co-processing technique, as a time and energy less consuming method in comparison
with commonly applied techniques such as spray drying and wet granulation. According to the results
obtained, by co-processing lactose with selected lipid excipients excellent flowability, as well as
improved tableting properties can be achieved. Novel co-processed excipients were even found to be
highly superior regarding their antiadhesive and lubricating properties in comparison to commercial
lactose-based co-processed excipients., Nedostatak direktno kompresibilnih ekscipijenasa i uvođenje proizvodne opreme velike brzine
rada dodatno su povećali interesovanje za razvoj koprocesovanih ekscipijenasa. U ovoj studiji, in situ
granulacija topljenjem u uređaju tipa fluidizirajućeg sistema (eng. fluidized bed melt granulation,
FBMG), kao ekološki prihvatljiva i ekonomična metoda, primenjena je za koprocesovanje najčešće
korišćenog sredstva za dopunjavanje, laktoze, monohidrata, sa lipidnim ekscipijensima,
glicerildibehenatom (Compritol® 888 ATO) ili glicerilpalmitostearatom (Precirol® ATO 5), koji su
poznati po svojim antiadhezivnim, lubrikatnim i protočnim osobinama (1, 2). Cilj ovog ispitivanja je bio
razvoj novih koprocesovanih ekscipijenasa na bazi lipida primenom ekološki prihvatljive metode, koja
ne zahteva upotrebu rastvarača, i ispitivanje njihove protočnosti i tabletabilnosti.
Protočne karakteristike ispitivanih uzoraka (pojedinačni ekscipijensi, njihove fizičke smeše,
laktoza ((85% (m/m)) koprocesovana sa Precirol ®-om ili Compritol®-om (15% (m/m)), i komercijalno
dostupni koprocesovani ekscipijensi na bazi laktoze (Retalac ® i Ludipress® )) procenjene su na osnovu
vrednosti Carr-ovog indeksa i Hausner‐ovog odnosa. Laboratorijski simulator kompakcije (GTP D serija,
Gamlen Tableting Ltd, UK) korišćen je za dinamičku analizu kompakcije.
Uporedive ili čak bolje protočne karakteristike koprocesovanih ekscipijensa dobijenih metodom
in situ FBMG, u poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima, ukazuju na
njihovu podobnost za direktnu kompresiju. Koprocesovani ekscipijensi sa Precirol®-om i Compritol ®-
om, kao i odgovarajuće fizičke smeše, pokazale su dva do skoro tri puta niže vrednosti ukupnog rada
kompresije od komercijalno dostupnih ekscipijenasa na bazi laktoze. Dodatno, koprocesovani
ekscipijensi na bazi lipida pokazali su do 50 puta manji rad odvajanja i do 20 puta manji rad izbacivanja
od Retalac ®-a i Ludipress® -a. Superiorna antiadhezivna i lubrikatna svojstva koprocesovanih
ekscipijenasa pripremljenih in situ FBMG mogu se pripisati lipidnim ekscipijensima. Komercijalno
dostupni kao i ispitivani koprocesovani ekscipijensi, na bazi lipidnih ekscipijenasa, pokazali su
relativno visoke vrednosti zatezne čvrstine (> 1,7 MPa).
Predstavljeni rezultati ukazuju na to da se granulacija topljenjem u uređaju tipa fluidizirajućeg
sistema može koristiti kao pogodna metoda za koprocesovanje, koja zahteva manji utrošak energije i
vremena u poređenju sa uobičajenim tehnikama, poput sušenja raspršivanjem ili vlažne granulacije.
Dobijeni rezultati pokazuju da se koprocesovanjem laktoze sa odabranim lipidnim ekscipijensima može
postići odlična protočnost, kao i poboljšana tabletabilnost. Novi koprocesovani ekscipijensi su čak
pokazali superiornije karakteristike u pogledu svojih antiadhezivnih i lubrikatnih karakteristika u
poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima na bazi laktoze.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Application of solventless granulation method for developent of novel co‐processed excipeints, Primena metode granulacije bez upotrebe rastvarača u razvoju novih koprocesovanih ekscipijenasa",
volume = "71",
number = "5 suplement",
pages = "S80-S81",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4671"
}

Ćirin-Varađan, S., Đuriš, J., Ibrić, S., Parojčić, J.,& Aleksić, I.. (2021). Application of solventless granulation method for developent of novel co‐processed excipeints. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S80-S81.
https://hdl.handle.net/21.15107/rcub_farfar_4671

Ćirin-Varađan S, Đuriš J, Ibrić S, Parojčić J, Aleksić I. Application of solventless granulation method for developent of novel co‐processed excipeints. in Arhiv za farmaciju. 2021;71(5 suplement):S80-S81.
https://hdl.handle.net/21.15107/rcub_farfar_4671 .

Ćirin-Varađan, Slobodanka, Đuriš, Jelena, Ibrić, Svetlana, Parojčić, Jelena, Aleksić, Ivana, "Application of solventless granulation method for developent of novel co‐processed excipeints" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S80-S81,
https://hdl.handle.net/21.15107/rcub_farfar_4671 .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Cirin-Varađan, Slobodanka
AU  - Aleksić, Ivana
AU  - Đuriš, Mihal
AU  - Cvijić, Sandra
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3905
AB  - Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.
PB  - MDPI AG
T2  - Pharmaceutics
T1  - Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
VL  - 13
IS  - 5
DO  - 10.3390/pharmaceutics13050663
ER  - 

@article{
author = "Đuriš, Jelena and Cirin-Varađan, Slobodanka and Aleksić, Ivana and Đuriš, Mihal and Cvijić, Sandra and Ibrić, Svetlana",
year = "2021",
abstract = "Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.",
publisher = "MDPI AG",
journal = "Pharmaceutics",
title = "Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients",
volume = "13",
number = "5",
doi = "10.3390/pharmaceutics13050663"
}

Đuriš, J., Cirin-Varađan, S., Aleksić, I., Đuriš, M., Cvijić, S.,& Ibrić, S.. (2021). Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients. in Pharmaceutics
MDPI AG., 13(5).
https://doi.org/10.3390/pharmaceutics13050663

Đuriš J, Cirin-Varađan S, Aleksić I, Đuriš M, Cvijić S, Ibrić S. Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients. in Pharmaceutics. 2021;13(5).
doi:10.3390/pharmaceutics13050663 .

Đuriš, Jelena, Cirin-Varađan, Slobodanka, Aleksić, Ivana, Đuriš, Mihal, Cvijić, Sandra, Ibrić, Svetlana, "Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients" in Pharmaceutics, 13, no. 5 (2021),
https://doi.org/10.3390/pharmaceutics13050663 . .

TY  - JOUR
AU  - Ignjatović, Jelisaveta
AU  - Đuriš, Jelena
AU  - Đuriš, Mihal
AU  - Bočarski, Teodora
AU  - Vasilijević, Vanja
AU  - Aleksić, Ivana
AU  - Cvijić, Sandra
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3808
AB  - Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated  material.  The  selected  substrates  included  highly  soluble  sodium  chloride  (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin.  Experiments  with  sodium  chloride  revealed  that  pan-coating  yielded  particles  of  more regular  shape,  while  mortar-coating  yielded  samples  of  more  uniform  coating  layer.  The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield  in  the  coated  samples  was  high  (99%),  the  material  showed  satisfactory  mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest  that  both  pan-  and  mortar-coating  can  be  used  to  sustain  the  release  of  drugs  with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies.
AB  - Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating
T1  - Procena metoda za oblaganje višečestičnih supstrata topljenjem - oblaganje u pateni vs. oblaganje u bubnju
VL  - 71
IS  - 1
SP  - 35
EP  - 54
DO  - 10.5937/arhfarm71-30266
ER  - 

@article{
author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Đuriš, Mihal and Bočarski, Teodora and Vasilijević, Vanja and Aleksić, Ivana and Cvijić, Sandra",
year = "2021",
abstract = "Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated  material.  The  selected  substrates  included  highly  soluble  sodium  chloride  (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin.  Experiments  with  sodium  chloride  revealed  that  pan-coating  yielded  particles  of  more regular  shape,  while  mortar-coating  yielded  samples  of  more  uniform  coating  layer.  The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield  in  the  coated  samples  was  high  (99%),  the  material  showed  satisfactory  mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest  that  both  pan-  and  mortar-coating  can  be  used  to  sustain  the  release  of  drugs  with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies., Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating, Procena metoda za oblaganje višečestičnih supstrata topljenjem - oblaganje u pateni vs. oblaganje u bubnju",
volume = "71",
number = "1",
pages = "35-54",
doi = "10.5937/arhfarm71-30266"
}

Ignjatović, J., Đuriš, J., Đuriš, M., Bočarski, T., Vasilijević, V., Aleksić, I.,& Cvijić, S.. (2021). Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(1), 35-54.
https://doi.org/10.5937/arhfarm71-30266

Ignjatović J, Đuriš J, Đuriš M, Bočarski T, Vasilijević V, Aleksić I, Cvijić S. Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating. in Arhiv za farmaciju. 2021;71(1):35-54.
doi:10.5937/arhfarm71-30266 .

Ignjatović, Jelisaveta, Đuriš, Jelena, Đuriš, Mihal, Bočarski, Teodora, Vasilijević, Vanja, Aleksić, Ivana, Cvijić, Sandra, "Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating" in Arhiv za farmaciju, 71, no. 1 (2021):35-54,
https://doi.org/10.5937/arhfarm71-30266 . .

TY  - CONF
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4661
AB  - Pharmaceutical industry is highly competitive, but tightly regulated industry which
makes the introduction of changes and innovations quite challenging. Therefore, while being
among the first industries to recognize the importance of moving towards sustainable, green
manufacturing, changes are still being implemented slowly, mostly by some leading
pharmaceutical companies. The reduction in energy consumption, carbon footprint and
waste discharge has been recognized as the core of the pharmaceutical industry
sustainability efforts. Particular attention has been given to implementation of green
chemistry principles into development and production of active pharmaceutical ingredients,
considering the significant environmental impacts of these processes (1). However, thorough
environmental considerations are needed, from the introduction of more energy efficient
approach in manufacturing sites design and logistic operations, replacement of traditional
technological processes with new, more environmentally friendly manufacturing concepts
and operations in medicines production, to reduction of waste and/or its reuse for energy
generation. Pharmaceutical companies have already started with transformation of its
production sites into smart, green factories using renewable energy sources such as
geothermal, wind, water and solar energy. Some of them have targeted its environmental
goals to minimised or even zero carbon footprint in the near future, as well as significantly
reduced water usage. To achieve such goals further changes are expected, including the
replacement of commonly used technological processes (associated with high energy
consumption and usage of organic solvents) with innovative technologies. Conventional
granulation and tablet coating methods, involved in production of solid dosage forms, are
example of methods that considerably contribute to overall greenhouse gas emissions from
pharmaceutical manufacturing plants. The variety of solvent-free and environmentally
friendly granulation and coating methods have been developed and intensively investigated
(2, 3), but strict and high regulatory demands usually lead to a reluctance of pharmaceutical
industry to implement the novel technologies. The introduction of automation and
continuous manufacturing is also expected to reduce the environmental impact of
pharmaceutical manufacturing due to the decreased waste generation, improved operational
and energy efficiency.
AB  - Farmaceutska industrija je visoko konkurentna, ali strogo regulisana zbog čega je
uvođenje promena i inovacija u proizvodnji lekova prilično izazovno. Upravo iz tih razloga, u
farmaceutskoj industriji, koja je među prvima prepoznala važnost prelaska na održivu,
zelenu proizvodnju, promene se i dalje uvode relativno sporo, uglavnom od strane vodećih
farmaceutskih kompanija. Kao ključni elementi u težnji farmaceutske industrije ka održivosti
prepoznati su smanjena potrošnja energije, smanjenje ugljeničnog otiska i ispuštenog
otpada. Posebna pažnja je posvećena primeni principa zelene hemije u razvoju i proizvodnji
lekovitih supstanci, imajući u vidu značajan uticaj ovih procesa na životnu sredinu (1).
Međutim, potrebna su temeljnija ekološka razmatranja, počev od primene energetski
efikasnijih pristupa u dizajnu proizvodnih pogona i logističkih operacija, preko zamene
tradicionalnih tehnoloških postupaka u proizvodnji lekova novim, ekološki prihvatljivijim
proizvodnim konceptima i postupcima, do smanjenog generisanja otpada i/ili upotrebe
otpada za proizvodnju energije. Neke farmaceutske kompanije su već počele sa
preuređenjem svojih proizvodnih pogona u pametne, zelene fabrike koje koriste obnovljive
izvore energije, kao što su geotermalna, solarna energija, energija vetra ili vode. Neke od
kompanija su postavile kao svoje ekološke ciljeve za blisku budućnost minimalan ili čak
ugljenični otisak jednak nuli, kao i znatno smanjenu potrošnju vode. Kako bi se ovakvi ciljevi
mogli dostići biće potrebne dalje promene, uključujući zamenu uobičajeno primenjivanih
tehnoloških postupaka (koje prati visoka potrošnja energije i upotreba organskih rastvarača)
inovativnim tehnologijama. Konvencionalne metode granulacije i oblaganja, koje se
primenjuju u proizvodnji čvrstih farmaceutskih oblika, predstavljaju primer postupaka u
proizvodnji lekova koji znatno doprinose emisiji gasova koji izazivaju efekat staklene bašte.
Razvijene su i intenzivno se istražuju različite, ekološki prihvatljive metode granulacije i
oblaganja, odnosno metode koje ne podrazumevaju upotrebu rastvarača (2, 3). Međutim, u
farmaceutskoj industriji je, usled strogih regulatornih zahteva, često prisutno izvesno
oklevanje kada je u pitanju uvođenju novih tehnologija. Očekuje se da će i uvođenje
automatizacije i kontinuirane proizvodnje doprineti manjem uticaju proizvodnje lekova na
životnu sredinu, usled manje količine otpada i poboljšane operativne i energetske
efikasnosti.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Green pharmaceutical manufacturing: approaches and perspectives
T1  - „Zelena” proizvodnja lekova: pristupi i perspektive
VL  - 71
IS  - 5 suplement
SP  - S14
EP  - S15
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4661
ER  - 

@conference{
author = "Aleksić, Ivana",
year = "2021",
abstract = "Pharmaceutical industry is highly competitive, but tightly regulated industry which
makes the introduction of changes and innovations quite challenging. Therefore, while being
among the first industries to recognize the importance of moving towards sustainable, green
manufacturing, changes are still being implemented slowly, mostly by some leading
pharmaceutical companies. The reduction in energy consumption, carbon footprint and
waste discharge has been recognized as the core of the pharmaceutical industry
sustainability efforts. Particular attention has been given to implementation of green
chemistry principles into development and production of active pharmaceutical ingredients,
considering the significant environmental impacts of these processes (1). However, thorough
environmental considerations are needed, from the introduction of more energy efficient
approach in manufacturing sites design and logistic operations, replacement of traditional
technological processes with new, more environmentally friendly manufacturing concepts
and operations in medicines production, to reduction of waste and/or its reuse for energy
generation. Pharmaceutical companies have already started with transformation of its
production sites into smart, green factories using renewable energy sources such as
geothermal, wind, water and solar energy. Some of them have targeted its environmental
goals to minimised or even zero carbon footprint in the near future, as well as significantly
reduced water usage. To achieve such goals further changes are expected, including the
replacement of commonly used technological processes (associated with high energy
consumption and usage of organic solvents) with innovative technologies. Conventional
granulation and tablet coating methods, involved in production of solid dosage forms, are
example of methods that considerably contribute to overall greenhouse gas emissions from
pharmaceutical manufacturing plants. The variety of solvent-free and environmentally
friendly granulation and coating methods have been developed and intensively investigated
(2, 3), but strict and high regulatory demands usually lead to a reluctance of pharmaceutical
industry to implement the novel technologies. The introduction of automation and
continuous manufacturing is also expected to reduce the environmental impact of
pharmaceutical manufacturing due to the decreased waste generation, improved operational
and energy efficiency., Farmaceutska industrija je visoko konkurentna, ali strogo regulisana zbog čega je
uvođenje promena i inovacija u proizvodnji lekova prilično izazovno. Upravo iz tih razloga, u
farmaceutskoj industriji, koja je među prvima prepoznala važnost prelaska na održivu,
zelenu proizvodnju, promene se i dalje uvode relativno sporo, uglavnom od strane vodećih
farmaceutskih kompanija. Kao ključni elementi u težnji farmaceutske industrije ka održivosti
prepoznati su smanjena potrošnja energije, smanjenje ugljeničnog otiska i ispuštenog
otpada. Posebna pažnja je posvećena primeni principa zelene hemije u razvoju i proizvodnji
lekovitih supstanci, imajući u vidu značajan uticaj ovih procesa na životnu sredinu (1).
Međutim, potrebna su temeljnija ekološka razmatranja, počev od primene energetski
efikasnijih pristupa u dizajnu proizvodnih pogona i logističkih operacija, preko zamene
tradicionalnih tehnoloških postupaka u proizvodnji lekova novim, ekološki prihvatljivijim
proizvodnim konceptima i postupcima, do smanjenog generisanja otpada i/ili upotrebe
otpada za proizvodnju energije. Neke farmaceutske kompanije su već počele sa
preuređenjem svojih proizvodnih pogona u pametne, zelene fabrike koje koriste obnovljive
izvore energije, kao što su geotermalna, solarna energija, energija vetra ili vode. Neke od
kompanija su postavile kao svoje ekološke ciljeve za blisku budućnost minimalan ili čak
ugljenični otisak jednak nuli, kao i znatno smanjenu potrošnju vode. Kako bi se ovakvi ciljevi
mogli dostići biće potrebne dalje promene, uključujući zamenu uobičajeno primenjivanih
tehnoloških postupaka (koje prati visoka potrošnja energije i upotreba organskih rastvarača)
inovativnim tehnologijama. Konvencionalne metode granulacije i oblaganja, koje se
primenjuju u proizvodnji čvrstih farmaceutskih oblika, predstavljaju primer postupaka u
proizvodnji lekova koji znatno doprinose emisiji gasova koji izazivaju efekat staklene bašte.
Razvijene su i intenzivno se istražuju različite, ekološki prihvatljive metode granulacije i
oblaganja, odnosno metode koje ne podrazumevaju upotrebu rastvarača (2, 3). Međutim, u
farmaceutskoj industriji je, usled strogih regulatornih zahteva, često prisutno izvesno
oklevanje kada je u pitanju uvođenju novih tehnologija. Očekuje se da će i uvođenje
automatizacije i kontinuirane proizvodnje doprineti manjem uticaju proizvodnje lekova na
životnu sredinu, usled manje količine otpada i poboljšane operativne i energetske
efikasnosti.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Green pharmaceutical manufacturing: approaches and perspectives, „Zelena” proizvodnja lekova: pristupi i perspektive",
volume = "71",
number = "5 suplement",
pages = "S14-S15",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4661"
}

Aleksić, I.. (2021). Green pharmaceutical manufacturing: approaches and perspectives. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S14-S15.
https://hdl.handle.net/21.15107/rcub_farfar_4661

Aleksić I. Green pharmaceutical manufacturing: approaches and perspectives. in Arhiv za farmaciju. 2021;71(5 suplement):S14-S15.
https://hdl.handle.net/21.15107/rcub_farfar_4661 .

Aleksić, Ivana, "Green pharmaceutical manufacturing: approaches and perspectives" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S14-S15,
https://hdl.handle.net/21.15107/rcub_farfar_4661 .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Nenadović, Snežana
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3921
AB  - Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Investigation into liquisolid system processability based on the SeDeM Expert System approach
VL  - 605
DO  - 10.1016/j.ijpharm.2021.120847
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Nenadović, Snežana and Mirković, Miljana and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Investigation into liquisolid system processability based on the SeDeM Expert System approach",
volume = "605",
doi = "10.1016/j.ijpharm.2021.120847"
}

Vasiljević, I., Turković, E., Nenadović, S., Mirković, M., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 605.
https://doi.org/10.1016/j.ijpharm.2021.120847

Vasiljević I, Turković E, Nenadović S, Mirković M, Zimmer A, Parojčić J, Aleksić I. Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2021;605.
doi:10.1016/j.ijpharm.2021.120847 .

Vasiljević, Ivana, Turković, Erna, Nenadović, Snežana, Mirković, Miljana, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Investigation into liquisolid system processability based on the SeDeM Expert System approach" in International Journal of Pharmaceutics, 605 (2021),
https://doi.org/10.1016/j.ijpharm.2021.120847 . .

TY  - JOUR
AU  - Aleksić, Ivana
AU  - German Ilić, Ilija
AU  - Cvijić, Sandra
AU  - Parojčić, Jelena
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3652
AB  - Liquisolid technology, as a promising approach for bioavailability enhancement, has received increasing attention in recent years. However, literature reports addressing the challenges for its industrial application, particularly those related to compaction behavior of liquisolid systems, are scarce. The aim of this study was to investigate the influence of process parameters and formulation variables on the flowability, wetting, and compaction properties of the liquisolid systems prepared in a fluid bed processor. The experiments with microcrystalline cellulose, as a carrier, were performed according to 23 full factorial design. The effects of liquid content, spray air pressure, and liquid feed rate on the properties of liquisolid systems were investigated. Liquisolid admixtures with microcrystalline cellulose were compared with those prepared with novel carriers, Fujicalin® and Neusilin® US2. “Out-die” Heckel, modified Walker, and Kuentz-Leuenberger models were used to analyze the compressibility of liquisolid admixtures. The results obtained showed that an increase in liquid content (in the range of 10 to 15%) led to a decrease in flowability of liquisolid admixtures with microcrystalline cellulose, as well as more pronounced influence of spraying conditions. On the other hand, higher liquid content led to higher compressibility. Fujicalin® and Neusilin® US2 liquisolid admixtures were found to have superior flowability and compressibility in comparison with those with microcrystalline cellulose, despite the considerably higher liquid load (50–55% liquid content in Neusilin® US2 compacts). Acceptable compactibility of the investigated liquisolid systems was observed. The fluid bed processor was shown to be suitable equipment for production of liquisolid systems, but with careful adjustment of process parameters.
PB  - Springer
T2  - AAPS PharmSciTech
T1  - An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems
VL  - 21
IS  - 7
DO  - 10.1208/s12249-020-01781-2
ER  - 

@article{
author = "Aleksić, Ivana and German Ilić, Ilija and Cvijić, Sandra and Parojčić, Jelena",
year = "2020",
abstract = "Liquisolid technology, as a promising approach for bioavailability enhancement, has received increasing attention in recent years. However, literature reports addressing the challenges for its industrial application, particularly those related to compaction behavior of liquisolid systems, are scarce. The aim of this study was to investigate the influence of process parameters and formulation variables on the flowability, wetting, and compaction properties of the liquisolid systems prepared in a fluid bed processor. The experiments with microcrystalline cellulose, as a carrier, were performed according to 23 full factorial design. The effects of liquid content, spray air pressure, and liquid feed rate on the properties of liquisolid systems were investigated. Liquisolid admixtures with microcrystalline cellulose were compared with those prepared with novel carriers, Fujicalin® and Neusilin® US2. “Out-die” Heckel, modified Walker, and Kuentz-Leuenberger models were used to analyze the compressibility of liquisolid admixtures. The results obtained showed that an increase in liquid content (in the range of 10 to 15%) led to a decrease in flowability of liquisolid admixtures with microcrystalline cellulose, as well as more pronounced influence of spraying conditions. On the other hand, higher liquid content led to higher compressibility. Fujicalin® and Neusilin® US2 liquisolid admixtures were found to have superior flowability and compressibility in comparison with those with microcrystalline cellulose, despite the considerably higher liquid load (50–55% liquid content in Neusilin® US2 compacts). Acceptable compactibility of the investigated liquisolid systems was observed. The fluid bed processor was shown to be suitable equipment for production of liquisolid systems, but with careful adjustment of process parameters.",
publisher = "Springer",
journal = "AAPS PharmSciTech",
title = "An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems",
volume = "21",
number = "7",
doi = "10.1208/s12249-020-01781-2"
}

Aleksić, I., German Ilić, I., Cvijić, S.,& Parojčić, J.. (2020). An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems. in AAPS PharmSciTech
Springer., 21(7).
https://doi.org/10.1208/s12249-020-01781-2

Aleksić I, German Ilić I, Cvijić S, Parojčić J. An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems. in AAPS PharmSciTech. 2020;21(7).
doi:10.1208/s12249-020-01781-2 .

Aleksić, Ivana, German Ilić, Ilija, Cvijić, Sandra, Parojčić, Jelena, "An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction Properties of Liquisolid Systems" in AAPS PharmSciTech, 21, no. 7 (2020),
https://doi.org/10.1208/s12249-020-01781-2 . .

TY  - JOUR
AU  - Milanović, Ana
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Cvijić, Sandra
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3508
AB  - Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. However, tableting properties of HMC granules have not been studied yet. In this work, we explored the influence of the lipid coating on granules tableting properties, and assessed quality attributes of the obtained tablets. Paracetamol granules, previously coated with the lipid excipient Precirol® ATO 5 using a hot-melt coating technique in modified fluidized-bed system, were evaluated in terms of work of compression, elastic recovery, tablets tensile strength, detachment stress and ejection stress. Regarding the product quality, tablets content uniformity, friability, disintegration time and drug release properties were tested. Our results demonstrated that tablets made of coated granules exhibited more pronounced elastic behaviour, and increased tensile strength in comparison to tablets made of uncoated granules, suggesting that lipid coating promotes elastic deformation and forms lipid matrix within the tablets. Additionally, low detachment and ejection stresses for tablets made of HMC granules indicated no need to add lubricant prior to tableting process. Evaluation of tablets properties revealed that tablets friability was not influenced by the presence of lipid coating on the compressed granules. However, formation of lipid matrix within the tablets made of HMC granules resulted in prolonged tablet disintegration time, and sustained drug release. Moreover, the performance of lipid matrix tablets, in terms of drug dissolution rate, was relatively insensitive to compression pressure variations in 104–173 MPa range. The obtained results indicate that tableting of HMC granules is a promising technique to obtain sustained release lipid matrix tablets of suitable pharmaceutical-technical properties.
PB  - Elsevier B.V.
T2  - European Journal of Pharmaceutical Sciences
T1  - Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets
VL  - 142
DO  - 10.1016/j.ejps.2019.105121
ER  - 

@article{
author = "Milanović, Ana and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena and Cvijić, Sandra",
year = "2020",
abstract = "Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. However, tableting properties of HMC granules have not been studied yet. In this work, we explored the influence of the lipid coating on granules tableting properties, and assessed quality attributes of the obtained tablets. Paracetamol granules, previously coated with the lipid excipient Precirol® ATO 5 using a hot-melt coating technique in modified fluidized-bed system, were evaluated in terms of work of compression, elastic recovery, tablets tensile strength, detachment stress and ejection stress. Regarding the product quality, tablets content uniformity, friability, disintegration time and drug release properties were tested. Our results demonstrated that tablets made of coated granules exhibited more pronounced elastic behaviour, and increased tensile strength in comparison to tablets made of uncoated granules, suggesting that lipid coating promotes elastic deformation and forms lipid matrix within the tablets. Additionally, low detachment and ejection stresses for tablets made of HMC granules indicated no need to add lubricant prior to tableting process. Evaluation of tablets properties revealed that tablets friability was not influenced by the presence of lipid coating on the compressed granules. However, formation of lipid matrix within the tablets made of HMC granules resulted in prolonged tablet disintegration time, and sustained drug release. Moreover, the performance of lipid matrix tablets, in terms of drug dissolution rate, was relatively insensitive to compression pressure variations in 104–173 MPa range. The obtained results indicate that tableting of HMC granules is a promising technique to obtain sustained release lipid matrix tablets of suitable pharmaceutical-technical properties.",
publisher = "Elsevier B.V.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets",
volume = "142",
doi = "10.1016/j.ejps.2019.105121"
}

Milanović, A., Aleksić, I., Ibrić, S., Parojčić, J.,& Cvijić, S.. (2020). Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets. in European Journal of Pharmaceutical Sciences
Elsevier B.V.., 142.
https://doi.org/10.1016/j.ejps.2019.105121

Milanović A, Aleksić I, Ibrić S, Parojčić J, Cvijić S. Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets. in European Journal of Pharmaceutical Sciences. 2020;142.
doi:10.1016/j.ejps.2019.105121 .

Milanović, Ana, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, Cvijić, Sandra, "Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality characteristics of the obtained tablets" in European Journal of Pharmaceutical Sciences, 142 (2020),
https://doi.org/10.1016/j.ejps.2019.105121 . .