TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Ibrić, Svetlana
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5318
AB  - Expert System for Drug Development, i.e. SeDeM
Expert System (Span. Sistema Experto para DEsarrollo
de Medicamentos) represents a method intended for
evaluation of powder properties affecting processability,
particularly compression behavior (Pérez et al., 2006).
Additionally, it is recognized as useful formulation tool,
since it provides identification of impaired powder
properties and facilitates formulation development
suitable for direct compression, based on mathematical
equations. Relevant parameters described in SeDeM
Expert System are divided into 5 groups and denoted as
“incidence factors”, namely: Density, Compression,
Flowability, Particle Size and Stability (Aguilar-Díaz et
al., 2014).
The aim of this work was to investigate mannitol-
and lactose-based co-processed excipients, based on
SeDeM Expert System methodology, and assess its
suitability for compressible formulation development. ...
PB  - Macedonian Pharmaceutical Association
PB  - Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje
C3  - Macedonian Pharmaceutical Bulletin
T1  - Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development
VL  - 68
IS  - Suppl 1
SP  - 223
EP  - 224
DO  - 10.33320/maced.pharm.bull.2022.68.03.106
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Ibrić, Svetlana and Vasiljević, Dragana and Parojčić, Jelena",
year = "2022",
abstract = "Expert System for Drug Development, i.e. SeDeM
Expert System (Span. Sistema Experto para DEsarrollo
de Medicamentos) represents a method intended for
evaluation of powder properties affecting processability,
particularly compression behavior (Pérez et al., 2006).
Additionally, it is recognized as useful formulation tool,
since it provides identification of impaired powder
properties and facilitates formulation development
suitable for direct compression, based on mathematical
equations. Relevant parameters described in SeDeM
Expert System are divided into 5 groups and denoted as
“incidence factors”, namely: Density, Compression,
Flowability, Particle Size and Stability (Aguilar-Díaz et
al., 2014).
The aim of this work was to investigate mannitol-
and lactose-based co-processed excipients, based on
SeDeM Expert System methodology, and assess its
suitability for compressible formulation development. ...",
publisher = "Macedonian Pharmaceutical Association, Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development",
volume = "68",
number = "Suppl 1",
pages = "223-224",
doi = "10.33320/maced.pharm.bull.2022.68.03.106"
}

Vasiljević, I., Turković, E., Ibrić, S., Vasiljević, D.,& Parojčić, J.. (2022). Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 68(Suppl 1), 223-224.
https://doi.org/10.33320/maced.pharm.bull.2022.68.03.106

Vasiljević I, Turković E, Ibrić S, Vasiljević D, Parojčić J. Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development. in Macedonian Pharmaceutical Bulletin. 2022;68(Suppl 1):223-224.
doi:10.33320/maced.pharm.bull.2022.68.03.106 .

Vasiljević, Ivana, Turković, Erna, Ibrić, Svetlana, Vasiljević, Dragana, Parojčić, Jelena, "Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development" in Macedonian Pharmaceutical Bulletin, 68, no. Suppl 1 (2022):223-224,
https://doi.org/10.33320/maced.pharm.bull.2022.68.03.106 . .

TY  - JOUR
AU  - Osmanović Omerdić, Ehlimana
AU  - Alagić-Džambić, Larisa
AU  - Krstić, Marko
AU  - Pašić-Kulenović, Maja
AU  - Medarević, Đorđe
AU  - Ivković, Branka
AU  - Vasiljević, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4085
AB  - Formulation of solid dispersions (SDs), in which the drug substance is dissolved or dispersed inside a polymer matrix, is one of the modern approaches to increase the solubility and dissolution rate of poorly soluble active pharmaceutical ingredients (APIs), such as clopidogrel. In the form of a free base, clopidogrel is unstable under increased both high moisture and temperature, so it is most often used as its salt form, clopidogrel hydrogen sulfate (CHS).The aim of this study was the formulation, characterization, and long-term stability investigation of CHS solid dispersions, prepared with four different hydrophilic polymers (poloxamer 407, macrogol 6000, povidone, copovidone) in five API/polymer ratios (1:1, 1:2, 1:3, 1:5, 1:9). SDs were prepared by the solvent evaporation method, employing ethanol (96% v/v) as a solvent. Initial results of the in vitro dissolution test showed an increase in the amount of dissolved CHS from all prepared SD samples compared to pure CHS, corresponding physical mixtures (PMs), and commercial tablets. SDs, prepared with poloxamer 407, macrogol 6000, and copovidone, at CHS/polymer ratios 1:5 and 1:9, notably increased the amount of dissolved CHS (> 80%, after 60 min), thus they were selected for further characterization. To assess the SDs long-term stability, in vitro dissolution studies, clopidogrel content determination, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FT-IR) were performed initially and after 12 months of long-term stability studies under controlled conditions (25°C, 60% RH) meeting the ICH guideline Q1A (R2) requirements. The clopidogrel content in the selected samples was very similar at the beginning (96.13% to 99.93%) and at the end (95.98% to 99.86%) of the conducted test. DSC curves and FT-IR spectra of all SD samples after 12 months of stability study, showed the absence of CHS crystallization, which is an indication of good stability. However, the in vitro dissolution test showed a considerable reduction in CHS released from SDs with macrogol 6000. The amount of dissolved CHS from SDs with macrogol 6000 was initially 94.02% and 92.01%, and after 12 months of stability study, only 65.13% and 49.62%. In contrast, the amount of dissolved CHS from SDs prepared with poloxamer 407 and copovidone was very similar after 12 months of the stability study compared to the initial values. Results obtained indicated the great importance of the in vitro dissolution test in determining the long-term stability and quality of SDs.
PB  - NLM (Medline)
T2  - PloS one
T1  - Long-term stability of clopidogrel solid dispersions-Importance of in vitro dissolution test
VL  - 17
IS  - 4
DO  - 10.1371/journal.pone.0266237
ER  - 

@article{
author = "Osmanović Omerdić, Ehlimana and Alagić-Džambić, Larisa and Krstić, Marko and Pašić-Kulenović, Maja and Medarević, Đorđe and Ivković, Branka and Vasiljević, Dragana",
year = "2022",
abstract = "Formulation of solid dispersions (SDs), in which the drug substance is dissolved or dispersed inside a polymer matrix, is one of the modern approaches to increase the solubility and dissolution rate of poorly soluble active pharmaceutical ingredients (APIs), such as clopidogrel. In the form of a free base, clopidogrel is unstable under increased both high moisture and temperature, so it is most often used as its salt form, clopidogrel hydrogen sulfate (CHS).The aim of this study was the formulation, characterization, and long-term stability investigation of CHS solid dispersions, prepared with four different hydrophilic polymers (poloxamer 407, macrogol 6000, povidone, copovidone) in five API/polymer ratios (1:1, 1:2, 1:3, 1:5, 1:9). SDs were prepared by the solvent evaporation method, employing ethanol (96% v/v) as a solvent. Initial results of the in vitro dissolution test showed an increase in the amount of dissolved CHS from all prepared SD samples compared to pure CHS, corresponding physical mixtures (PMs), and commercial tablets. SDs, prepared with poloxamer 407, macrogol 6000, and copovidone, at CHS/polymer ratios 1:5 and 1:9, notably increased the amount of dissolved CHS (> 80%, after 60 min), thus they were selected for further characterization. To assess the SDs long-term stability, in vitro dissolution studies, clopidogrel content determination, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FT-IR) were performed initially and after 12 months of long-term stability studies under controlled conditions (25°C, 60% RH) meeting the ICH guideline Q1A (R2) requirements. The clopidogrel content in the selected samples was very similar at the beginning (96.13% to 99.93%) and at the end (95.98% to 99.86%) of the conducted test. DSC curves and FT-IR spectra of all SD samples after 12 months of stability study, showed the absence of CHS crystallization, which is an indication of good stability. However, the in vitro dissolution test showed a considerable reduction in CHS released from SDs with macrogol 6000. The amount of dissolved CHS from SDs with macrogol 6000 was initially 94.02% and 92.01%, and after 12 months of stability study, only 65.13% and 49.62%. In contrast, the amount of dissolved CHS from SDs prepared with poloxamer 407 and copovidone was very similar after 12 months of the stability study compared to the initial values. Results obtained indicated the great importance of the in vitro dissolution test in determining the long-term stability and quality of SDs.",
publisher = "NLM (Medline)",
journal = "PloS one",
title = "Long-term stability of clopidogrel solid dispersions-Importance of in vitro dissolution test",
volume = "17",
number = "4",
doi = "10.1371/journal.pone.0266237"
}

Osmanović Omerdić, E., Alagić-Džambić, L., Krstić, M., Pašić-Kulenović, M., Medarević, Đ., Ivković, B.,& Vasiljević, D.. (2022). Long-term stability of clopidogrel solid dispersions-Importance of in vitro dissolution test. in PloS one
NLM (Medline)., 17(4).
https://doi.org/10.1371/journal.pone.0266237

Osmanović Omerdić E, Alagić-Džambić L, Krstić M, Pašić-Kulenović M, Medarević Đ, Ivković B, Vasiljević D. Long-term stability of clopidogrel solid dispersions-Importance of in vitro dissolution test. in PloS one. 2022;17(4).
doi:10.1371/journal.pone.0266237 .

Osmanović Omerdić, Ehlimana, Alagić-Džambić, Larisa, Krstić, Marko, Pašić-Kulenović, Maja, Medarević, Đorđe, Ivković, Branka, Vasiljević, Dragana, "Long-term stability of clopidogrel solid dispersions-Importance of in vitro dissolution test" in PloS one, 17, no. 4 (2022),
https://doi.org/10.1371/journal.pone.0266237 . .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Vasiljević, Dragana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4758
AB  - 1. INTRODUCTION
Orodispersible films (ODF) have emerged as innovative dosage forms that provide wide variety of advantages for patients and manufacturers over conventional dosage forms. The prominent characteristic of ODFs is fast disintegration followed by good patients acceptability [1]. Therefore, relevant disintegration time (DT) is usually considered as ODF critical quality attribute. Extensive research on ODFs is generating a lot of data, but lack of standardization is the main obstacle that limits their comparative evaluation. The following work aims to explore literature data on ODFs characteristics using the predictive data-classification algorithm Support vector machine (SVM) and assess its applicability in pharmaceutical development based on the set of experimentally obtained data.
2. MATERIALS AND METHODS
2.1. Materials
Hydroxypropyl cellulose (Klucel GF, Ashland, USA), ethanol (≥99.8%, Honeywell, Charlotte, NC, USA) and glycerol, 85% (w/w) (Ph. Eur.) were used for preparation of printing and casting dispersion.
2.2. Data pre-processing
Comprehensive data exploration has been conducted in the PubMed database using most common synonyms for ODFs with fifteen synonyms in singular and plural. Built database had following attributes: manufacturing approach, polymer selection, polymer molecular weight (KDa), polymer load (%), mechanical properties (tensile strength (MPa), Young's modulus (MPa), elongation at break (%)), disintegration method and disintegration time (DT) (s).
2.3. ODF preparation and characterisation
Polymer dispersions for solvent casting and semi-solid extrusion 3D printing were prepared by dispersing HPC in ethanol:glicerol solution followed by continuous stirring on the magnetic stirrer. Prepared dispersions were: (i) casted on a unit-dose plexiglas plates, or (ii) printed using Ultimaker 2+ (Ultimaker, , Netherlands). ODFs were characterized in terms of mechanical properties using Z-LX Table-Top Testing Machine (Shimadzu, Japan) and DT using adapted compendial tester (Erweka ZT52, Germany) with a weight.
3. RESULTS AND DISCUSSION
3.1. Data pre-processing
274 papers (without reviews) were identified via search, of which 112 were included in the database. Nominal data from literature was transformed into numerical, using coding operator so that each nominal data had corresponding numerical value. Critical attributes for films fast disintegration were derived. 18 polymers were included as categorical data and were further differentiated on the basis of molecular weight. Values for most commonly evaluated mechanical properties were included as numerical data. Different DT methods were classified in seven classes (Table 1), while the manufacturing methods were classified in five classes. RapidMiner Studio 9.10 (RapidMiner, Dortmund, Germany) was used to transform data and employ SMV algorithm.
3.2. SVM model prediction
Attributes with the highest weight were polymer load and DT method employed (Figure 1). The polymer type and characteristic did have conclusive effects on DT as their weight varied during data mining. This can be attributed to inconclusive data provided in papers and lot of missing values for those attributes. Mechanical properties had low weight, which can be explained with the broad value range for those attributes. Different research groups had different approach to disintegration testing, which lowered model precision as it was reported that SVM does not have high accuracy when data is imbalanced [3]. Relative error value was 20%, which can be considered as high, but, having in mind great diversity in presented data and methodology, obtained value is still acceptable for the pilot study.
3.3. Experimental validation
HPC-based films prepared by 3D printing had tensile strength, elongation at break and Young’s modulus of 3.5 MPa, 137% and 5 MPa, respectively. Average DT was 69 s. For casted films, relevant values were 3.4 MPa, 105% and 3 MPa, and DT was 27 s. Experimentally obtained results were entered into model simulator (Figure 2) to simulate situation reflecting the experimental set up in which HPC-based films were prepared by 3D printing and solvent casting, and relevant attribute values obtained by samples characterization. In the case were manufacturing method was set to be 3D printing (coded as 1) predicted DT value was close to experimentally obtained value, i.e. 71.7 and 69 s, respectively. When solvent casting method was considered, predicted DT value was remarkedly higher than the experimentally obtained one, indicating bad predictability. It might be assumed that good predictability obtained in the case of 3D printed films is associated with lower data variability due to more simple sample composition and robust preparation method. In the case of casted films, data was much more complex due to a higher number of research papers and approaches to characterisation.
4. CONCLUSION
The obtained results indicate that SVM algorithm can be employed to predict ODF DT value based on the dataset created using literature data. However, in order to obtain meaningful predictions, larger dataset, with fewer inconsistences and less missing values would be advantageous.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - Application of support vector machine learning for orodispersible films disintegration time prediction
SP  - 239
EP  - 240
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4758
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Vasiljević, Dragana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "1. INTRODUCTION
Orodispersible films (ODF) have emerged as innovative dosage forms that provide wide variety of advantages for patients and manufacturers over conventional dosage forms. The prominent characteristic of ODFs is fast disintegration followed by good patients acceptability [1]. Therefore, relevant disintegration time (DT) is usually considered as ODF critical quality attribute. Extensive research on ODFs is generating a lot of data, but lack of standardization is the main obstacle that limits their comparative evaluation. The following work aims to explore literature data on ODFs characteristics using the predictive data-classification algorithm Support vector machine (SVM) and assess its applicability in pharmaceutical development based on the set of experimentally obtained data.
2. MATERIALS AND METHODS
2.1. Materials
Hydroxypropyl cellulose (Klucel GF, Ashland, USA), ethanol (≥99.8%, Honeywell, Charlotte, NC, USA) and glycerol, 85% (w/w) (Ph. Eur.) were used for preparation of printing and casting dispersion.
2.2. Data pre-processing
Comprehensive data exploration has been conducted in the PubMed database using most common synonyms for ODFs with fifteen synonyms in singular and plural. Built database had following attributes: manufacturing approach, polymer selection, polymer molecular weight (KDa), polymer load (%), mechanical properties (tensile strength (MPa), Young's modulus (MPa), elongation at break (%)), disintegration method and disintegration time (DT) (s).
2.3. ODF preparation and characterisation
Polymer dispersions for solvent casting and semi-solid extrusion 3D printing were prepared by dispersing HPC in ethanol:glicerol solution followed by continuous stirring on the magnetic stirrer. Prepared dispersions were: (i) casted on a unit-dose plexiglas plates, or (ii) printed using Ultimaker 2+ (Ultimaker, , Netherlands). ODFs were characterized in terms of mechanical properties using Z-LX Table-Top Testing Machine (Shimadzu, Japan) and DT using adapted compendial tester (Erweka ZT52, Germany) with a weight.
3. RESULTS AND DISCUSSION
3.1. Data pre-processing
274 papers (without reviews) were identified via search, of which 112 were included in the database. Nominal data from literature was transformed into numerical, using coding operator so that each nominal data had corresponding numerical value. Critical attributes for films fast disintegration were derived. 18 polymers were included as categorical data and were further differentiated on the basis of molecular weight. Values for most commonly evaluated mechanical properties were included as numerical data. Different DT methods were classified in seven classes (Table 1), while the manufacturing methods were classified in five classes. RapidMiner Studio 9.10 (RapidMiner, Dortmund, Germany) was used to transform data and employ SMV algorithm.
3.2. SVM model prediction
Attributes with the highest weight were polymer load and DT method employed (Figure 1). The polymer type and characteristic did have conclusive effects on DT as their weight varied during data mining. This can be attributed to inconclusive data provided in papers and lot of missing values for those attributes. Mechanical properties had low weight, which can be explained with the broad value range for those attributes. Different research groups had different approach to disintegration testing, which lowered model precision as it was reported that SVM does not have high accuracy when data is imbalanced [3]. Relative error value was 20%, which can be considered as high, but, having in mind great diversity in presented data and methodology, obtained value is still acceptable for the pilot study.
3.3. Experimental validation
HPC-based films prepared by 3D printing had tensile strength, elongation at break and Young’s modulus of 3.5 MPa, 137% and 5 MPa, respectively. Average DT was 69 s. For casted films, relevant values were 3.4 MPa, 105% and 3 MPa, and DT was 27 s. Experimentally obtained results were entered into model simulator (Figure 2) to simulate situation reflecting the experimental set up in which HPC-based films were prepared by 3D printing and solvent casting, and relevant attribute values obtained by samples characterization. In the case were manufacturing method was set to be 3D printing (coded as 1) predicted DT value was close to experimentally obtained value, i.e. 71.7 and 69 s, respectively. When solvent casting method was considered, predicted DT value was remarkedly higher than the experimentally obtained one, indicating bad predictability. It might be assumed that good predictability obtained in the case of 3D printed films is associated with lower data variability due to more simple sample composition and robust preparation method. In the case of casted films, data was much more complex due to a higher number of research papers and approaches to characterisation.
4. CONCLUSION
The obtained results indicate that SVM algorithm can be employed to predict ODF DT value based on the dataset created using literature data. However, in order to obtain meaningful predictions, larger dataset, with fewer inconsistences and less missing values would be advantageous.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "Application of support vector machine learning for orodispersible films disintegration time prediction",
pages = "239-240",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4758"
}

Turković, E., Vasiljević, I., Vasiljević, D., Ibrić, S.,& Parojčić, J.. (2022). Application of support vector machine learning for orodispersible films disintegration time prediction. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 239-240.
https://hdl.handle.net/21.15107/rcub_farfar_4758

Turković E, Vasiljević I, Vasiljević D, Ibrić S, Parojčić J. Application of support vector machine learning for orodispersible films disintegration time prediction. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:239-240.
https://hdl.handle.net/21.15107/rcub_farfar_4758 .

Turković, Erna, Vasiljević, Ivana, Vasiljević, Dragana, Ibrić, Svetlana, Parojčić, Jelena, "Application of support vector machine learning for orodispersible films disintegration time prediction" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):239-240,
https://hdl.handle.net/21.15107/rcub_farfar_4758 .

TY  - CONF
AU  - Ćetković, Zora
AU  - Vasiljević, Ivana
AU  - Cvijić, Sandra
AU  - Vasiljević, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4567
AB  - Mixing selected liquid SMEDDS with polymethacrylate polymers (Eudragit ®) led to
solidification of the samples to form solid, ductile, transparent systems (1). The purpose of
this study was to define mechanical properties and long-term stability of novel simvastatin-
loaded SMEDDS-based drug delivery systems. SMEDDS-based formulations were prepared
by adding liquid SMEDDS (10% oleoyl macrogol-6 glycerides and 90% caprylocaproyl
macrogol-8 glycerides/macrogol-15-hydroxystearate, in 3 ratios: 1:1, 2:1 and 3:1) to
Eudragit ® S100 or Eudragit ® S100/Eudragit ® L100 combination (in 1:1 ratio), until
SMEDDS/polymer ratio 2:1 w/w was reached. SMEDDS-based formulations with simvastatin
(SV) were prepared by dissolving SV (5%) into liquid SMEDDS and mixing with
polymethacrylate polymers in the same ratio. Prepared formulations were evaluated in
terms of their mechanical properties and long-term stability. The results indicated that the
increase in the caprylocaproyl macrogol-8 glycerides concentration resulted in higher
penetration force (F1 S100–F3 S100 = 5.83-7.22 N and F1 SL100-F3 SL100 = 4.20-5.99 N).
However, addition of SV was negatively correlated with the hardness, i.e. samples with SV
were softer in comparison to unloaded samples. Moreover, it was noticeable that
formulations with Eudragit ® S100 had greater penetration force values compared to
formulations containing Eudragit ® S100/Eudragit ® L100. After six months of storage at
room and elevated temperature, only slight decrease in SV content (less than 5%) was
observed in these samples. This study demonstrated that novel SMEDDS-based formulations
with higher concentration of caprylocaproyl macrogol-8 glycerides and those with Eudragit ®
S100 were more robust, which may further serve as a guide for formulating tailor-made
formulations.
AB  - Mešanje odabranih tečnih samomikroemulgujućih sistema (SMEDDS) sa
kopolimerima metakrilne kiseline (Eudragit ® ) dovodi do očvršćavanja uzoraka i formiranja
čvrstih, rastegljivih, transparentnih sistema (1). Cilj ovog rada je bio ispitivanje mehaničkih
svojstva i dugotrajne stabilnosti novih lipidnih sistema sa simvastatinom (SV). Lipidne
formulacije su izrađene mešanjem tečnih SMEDDS (10% oleoil makrogol-6 glicerida i 90%
kaprilokaproil makrogol-8 glicerida/makrogol-15-hidroksistearat, u 3 odnosa: 1:1, 2:1 i 3:1)
i Eudragit ® S100 ili kombinacije Eudragit ® S100/Eudragit ® L100 (u odnosu 1:1). Odnos
SMEDDS/polimer bio je 2:1, m/m. Uzorci sa SV su izrađeni rastvaranjem SV (5%) u tečnim
SMEDDS i mešanjem sa kopolimerima metakrilne kiseline u navedenom odnosu. Sprovedena
su ispitivanja mehaničkih osobina i dugotrajne stabilnosti izrađenih lipidnih formulacija.
Rezultati su pokazali da povećanje koncentracije kaprilokaproil makrogol-8 glicerida dovodi
do povećanja vrednosti sile penetracije (F1 S100–F3 S100 = 5,83-7,22 N i F1 SL100-F3
SL100 = 4,20-5,99 N). Uzorci sa SV su bili mekši, u poređenju sa uzorcima bez lekovite
supstance. Takođe, uočeno je da uzorci sa polimerom Eudragit ® S100 imaju već e vrednosti
sile penetracije, u poređenju sa formulacijama koje sadrže kombinaciju Eudragit ®
S100/Eudragit ® L100. Posle šest meseci skladištenja uzoraka na sobnoj i povišenoj
temperaturi, sadržaj SV je neznatno smanjen (manje od 5%). Ova studija je pokazala da nove
lipidne formulacije izrađene sa većom koncentracijom kaprilokaproil makrogol-8 glicerida i
sa Eudragit ® S100 polimerom imaju veće vrednosti sile penetracije i prihvatljivu dugotrajnu
stabilnost, što je od značaja za razvoj lipidnih formulacija željenih karakteristika.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Mechanical properties and long-term stability of novel lipid formulations with simvastatin
T1  - Mehanička svojstva i dugotrajna stabilnost novih lipidnih formulacija sa simvastatinom
VL  - 72
IS  - 4 suplement
SP  - S396
EP  - S397
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4567
ER  - 

@conference{
author = "Ćetković, Zora and Vasiljević, Ivana and Cvijić, Sandra and Vasiljević, Dragana",
year = "2022",
abstract = "Mixing selected liquid SMEDDS with polymethacrylate polymers (Eudragit ®) led to
solidification of the samples to form solid, ductile, transparent systems (1). The purpose of
this study was to define mechanical properties and long-term stability of novel simvastatin-
loaded SMEDDS-based drug delivery systems. SMEDDS-based formulations were prepared
by adding liquid SMEDDS (10% oleoyl macrogol-6 glycerides and 90% caprylocaproyl
macrogol-8 glycerides/macrogol-15-hydroxystearate, in 3 ratios: 1:1, 2:1 and 3:1) to
Eudragit ® S100 or Eudragit ® S100/Eudragit ® L100 combination (in 1:1 ratio), until
SMEDDS/polymer ratio 2:1 w/w was reached. SMEDDS-based formulations with simvastatin
(SV) were prepared by dissolving SV (5%) into liquid SMEDDS and mixing with
polymethacrylate polymers in the same ratio. Prepared formulations were evaluated in
terms of their mechanical properties and long-term stability. The results indicated that the
increase in the caprylocaproyl macrogol-8 glycerides concentration resulted in higher
penetration force (F1 S100–F3 S100 = 5.83-7.22 N and F1 SL100-F3 SL100 = 4.20-5.99 N).
However, addition of SV was negatively correlated with the hardness, i.e. samples with SV
were softer in comparison to unloaded samples. Moreover, it was noticeable that
formulations with Eudragit ® S100 had greater penetration force values compared to
formulations containing Eudragit ® S100/Eudragit ® L100. After six months of storage at
room and elevated temperature, only slight decrease in SV content (less than 5%) was
observed in these samples. This study demonstrated that novel SMEDDS-based formulations
with higher concentration of caprylocaproyl macrogol-8 glycerides and those with Eudragit ®
S100 were more robust, which may further serve as a guide for formulating tailor-made
formulations., Mešanje odabranih tečnih samomikroemulgujućih sistema (SMEDDS) sa
kopolimerima metakrilne kiseline (Eudragit ® ) dovodi do očvršćavanja uzoraka i formiranja
čvrstih, rastegljivih, transparentnih sistema (1). Cilj ovog rada je bio ispitivanje mehaničkih
svojstva i dugotrajne stabilnosti novih lipidnih sistema sa simvastatinom (SV). Lipidne
formulacije su izrađene mešanjem tečnih SMEDDS (10% oleoil makrogol-6 glicerida i 90%
kaprilokaproil makrogol-8 glicerida/makrogol-15-hidroksistearat, u 3 odnosa: 1:1, 2:1 i 3:1)
i Eudragit ® S100 ili kombinacije Eudragit ® S100/Eudragit ® L100 (u odnosu 1:1). Odnos
SMEDDS/polimer bio je 2:1, m/m. Uzorci sa SV su izrađeni rastvaranjem SV (5%) u tečnim
SMEDDS i mešanjem sa kopolimerima metakrilne kiseline u navedenom odnosu. Sprovedena
su ispitivanja mehaničkih osobina i dugotrajne stabilnosti izrađenih lipidnih formulacija.
Rezultati su pokazali da povećanje koncentracije kaprilokaproil makrogol-8 glicerida dovodi
do povećanja vrednosti sile penetracije (F1 S100–F3 S100 = 5,83-7,22 N i F1 SL100-F3
SL100 = 4,20-5,99 N). Uzorci sa SV su bili mekši, u poređenju sa uzorcima bez lekovite
supstance. Takođe, uočeno je da uzorci sa polimerom Eudragit ® S100 imaju već e vrednosti
sile penetracije, u poređenju sa formulacijama koje sadrže kombinaciju Eudragit ®
S100/Eudragit ® L100. Posle šest meseci skladištenja uzoraka na sobnoj i povišenoj
temperaturi, sadržaj SV je neznatno smanjen (manje od 5%). Ova studija je pokazala da nove
lipidne formulacije izrađene sa većom koncentracijom kaprilokaproil makrogol-8 glicerida i
sa Eudragit ® S100 polimerom imaju veće vrednosti sile penetracije i prihvatljivu dugotrajnu
stabilnost, što je od značaja za razvoj lipidnih formulacija željenih karakteristika.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Mechanical properties and long-term stability of novel lipid formulations with simvastatin, Mehanička svojstva i dugotrajna stabilnost novih lipidnih formulacija sa simvastatinom",
volume = "72",
number = "4 suplement",
pages = "S396-S397",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4567"
}

Ćetković, Z., Vasiljević, I., Cvijić, S.,& Vasiljević, D.. (2022). Mechanical properties and long-term stability of novel lipid formulations with simvastatin. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S396-S397.
https://hdl.handle.net/21.15107/rcub_farfar_4567

Ćetković Z, Vasiljević I, Cvijić S, Vasiljević D. Mechanical properties and long-term stability of novel lipid formulations with simvastatin. in Arhiv za farmaciju. 2022;72(4 suplement):S396-S397.
https://hdl.handle.net/21.15107/rcub_farfar_4567 .

Ćetković, Zora, Vasiljević, Ivana, Cvijić, Sandra, Vasiljević, Dragana, "Mechanical properties and long-term stability of novel lipid formulations with simvastatin" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S396-S397,
https://hdl.handle.net/21.15107/rcub_farfar_4567 .

TY  - JOUR
AU  - Kovačević, Milena
AU  - Odalović, Marina
AU  - Đukić-Ćosić, Danijela
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
AU  - Tasić, Ljiljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4377
AB  - Background/Aim. Health professions education is facing
emerging issues. A comprehensive situation analysis was
performed among academic staff, healthcare practitioners,
and healthcare science students to address and respond to
new trends. The aim of the study was to investigate the
attitude, perception, and the recognized needs towards
experiential education (EE), interprofessional education
(IPE), and teaching competencies development (TCD). The
critical evaluation of the existing quality standards for
further quality improvement in health professions education
in Serbia was provided. Methods. The survey on EE, IPE,
and TCD was conducted within the Reinforcement of the
Framework for Experiential Education in Serbia
(ReFEEHS) project, co-funded by the Erasmus+ program
of the European Comission at four Serbian universities (the
University of Belgrade, the University of Kragujevac, the
University of Niš, and the University of Novi Sad). Four
task groups were appointed to perform a desk review of the
existing curricula, recommendations, and practices within
each of the four health professions education (Medicine,
Pharmacy, Dentistry, and Nursing) in Serbia and assess the
level of compliance with relevant educational policies and
practices in the European Union . Results. A total of 1,507
respondents completed the survey. A highly expressed
positive attitude was found towards EE, IPE, and TCD
among all the respondents. The majority of the respondents 
(> 70%) shared that EE should be organized in real-life
practice and involve students’ work under the supervision
of a qualified supervisor, as well as interactions with patients
and healthcare professionals. About 90% of the
respondents supported the inclusion of IPE teaching
activities into EE, with 77% of students expressing high
motivation to attend those classes, whereas 93% of
academic staff was eager to deliver and teach joint IPE
subjects. Only 20% of academic staff has already attended
some TCD program, while 75% recognized the need for its
organization. Moreover, 90% of healthcare practitioners
have recognized that mentors/clinical supervisors also need
additional skills for effective mentoring work within health
science education. Based on the survey results,
recommendations for improvement were given within three
educational fields, healthcare science curricula, professional
practice (traineeship), teaching staff, and regulations.
Conclusion. The results derived from the survey served as
a starting but also a vital point for higher education
improvement in Serbia. All interested parties – academia,
students, healthcare professionals, and regulatory bodies
should collaborate on achieving improved, contemporary,
and transformative health professions education.
AB  - Uvod/Cilj. Obrazovanje u oblasti zdravstva suočava se sa novim pitanjima. Da bi se odgovorilo na savremene zahteve obrazovanja zdravstvenih radnika, sprovedena je sveobuhvatna situaciona analiza. Cilj istraživanja bio je da se istraže stavovi, percepcije i prepoznaju potrebe akademske zajednice, zdravstvenih radnika i studenata zdravstvenih profesija, u odnosu prema učenju u realnom radnom okruženju, tj. nastavi u praksi (experiential education - EE), interprofesionalnom obrazovanju (interprofessional education - IPE) i unapređenju nastavničkih kompetencija (teaching competencies development - TCD). Radi daljeg unapređenja u oblasti obrazovanja, za zdravstvene radnike u Srbiji obezbeđeno je kritičko vrednovanje postojećih standarda kvaliteta. Metode. Istraživanje je sprovedeno u okviru projekta Reinforcement of the Framework for Experiential Education in Serbia (ReFEEHS), ko-finansiranog od strane Erasmus+ programa Evropske komisije na četiri univerziteta u Republici Srbiji (Univerzitet u Beogradu, Univerzitet u Kragujevcu, Univerzitet u Nišu i Univerzitet u Novom Sadu). Određene su četiri radne grupe, sa zadatkom razmatranja trenutnih kurikuluma, preporuka i prakse u okviru svake zdravstvene profesije (medicina, farmacija, stomatologija, sestrinstvo), kao i procene njihove usklađenosti sa relevantnim preporukama i praksom u obrazovanju u Evropskoj uniji. Rezultati. U istraživanju je učestvovalo 1 507 ispitanika. Pozitivan stav prema EE, IPE i TCD zabeležen je među svim ispitanicima. Više od 70% ispitanika iskazalo je stav o tome da je potrebno organizovati EE, tj. nastavu u praksi u realnom radnom okruženju, što bi podrazumevalo stručni rad studenata pod nadzorom kompetentnog mentora, ali i interakciju sa bolesnicima, kao i interakciju sa zdravstvenim radnicima. Oko 90% ispitanika podržalo je uključivanje IPE nastavnih aktivnosti u kurikulume; 77% studenata izrazilo je motivisanost da prisustvuju zajedničkim predmetima, dok je čak 93% nastavnika i saradnika iskazalo volju da učestvuju u kreiranju i podučavanju nastavnih jedinica u okviru IPE. Prethodno je samo 20% nastavnika/saradnika pohađalo neki TCD program, dok je čak 75% prepoznalo potrebu za organizacijom tih programa; 90% zdravstvenih radnika smatralo je da su za efikasan mentorski rad u obrazovanju u oblasti zdravstvene nauke potrebne dodatne veštine mentora/kliničkih supervizora. Na osnovu sagledanih rezultata upitnika, date su preporuke za unapređenje visokog obrazovanja u okviru tri obrazovne oblasti budućih zdravstvenih radnika, koje se odnose na kurikulum, studentsku stručnu praksu/klinički staž, nastavno osoblje i regulatorne aspekte. Zaključak. Dobijeni rezultati korišćeni su kao polazna, ali veoma značajna tačka za unapređenje visokog obrazovanja u Srbiji. Sve zainteresovane strane - akademska zajednica, studenti, zdravstveni radnici i regulatorna tela, treba da sarađuju u cilju postizanja unapređenog i savremenog obrazovanja zdravstvenih radnika.
PB  - Belgrade : Military Medical Academy
T2  - Vojnosanitetski pregled
T1  - Health professions education in Serbia: Evaluation and measures for quality improvement through experiential education, interprofessional education and teaching competencies development
T1  - Obrazovanje zdravstvenih radnika u Srbiji: procena i mere za unapređenje kvaliteta kroz praksu, interprofesionalno obrazovanje i razvoj nastavničkih kompetencija
VL  - 79
IS  - 11
SP  - 1119
EP  - 1129
DO  - 10.2298/VSP201005089K
ER  - 

@article{
author = "Kovačević, Milena and Odalović, Marina and Đukić-Ćosić, Danijela and Vasiljević, Dragana and Parojčić, Jelena and Tasić, Ljiljana",
year = "2022",
abstract = "Background/Aim. Health professions education is facing
emerging issues. A comprehensive situation analysis was
performed among academic staff, healthcare practitioners,
and healthcare science students to address and respond to
new trends. The aim of the study was to investigate the
attitude, perception, and the recognized needs towards
experiential education (EE), interprofessional education
(IPE), and teaching competencies development (TCD). The
critical evaluation of the existing quality standards for
further quality improvement in health professions education
in Serbia was provided. Methods. The survey on EE, IPE,
and TCD was conducted within the Reinforcement of the
Framework for Experiential Education in Serbia
(ReFEEHS) project, co-funded by the Erasmus+ program
of the European Comission at four Serbian universities (the
University of Belgrade, the University of Kragujevac, the
University of Niš, and the University of Novi Sad). Four
task groups were appointed to perform a desk review of the
existing curricula, recommendations, and practices within
each of the four health professions education (Medicine,
Pharmacy, Dentistry, and Nursing) in Serbia and assess the
level of compliance with relevant educational policies and
practices in the European Union . Results. A total of 1,507
respondents completed the survey. A highly expressed
positive attitude was found towards EE, IPE, and TCD
among all the respondents. The majority of the respondents 
(> 70%) shared that EE should be organized in real-life
practice and involve students’ work under the supervision
of a qualified supervisor, as well as interactions with patients
and healthcare professionals. About 90% of the
respondents supported the inclusion of IPE teaching
activities into EE, with 77% of students expressing high
motivation to attend those classes, whereas 93% of
academic staff was eager to deliver and teach joint IPE
subjects. Only 20% of academic staff has already attended
some TCD program, while 75% recognized the need for its
organization. Moreover, 90% of healthcare practitioners
have recognized that mentors/clinical supervisors also need
additional skills for effective mentoring work within health
science education. Based on the survey results,
recommendations for improvement were given within three
educational fields, healthcare science curricula, professional
practice (traineeship), teaching staff, and regulations.
Conclusion. The results derived from the survey served as
a starting but also a vital point for higher education
improvement in Serbia. All interested parties – academia,
students, healthcare professionals, and regulatory bodies
should collaborate on achieving improved, contemporary,
and transformative health professions education., Uvod/Cilj. Obrazovanje u oblasti zdravstva suočava se sa novim pitanjima. Da bi se odgovorilo na savremene zahteve obrazovanja zdravstvenih radnika, sprovedena je sveobuhvatna situaciona analiza. Cilj istraživanja bio je da se istraže stavovi, percepcije i prepoznaju potrebe akademske zajednice, zdravstvenih radnika i studenata zdravstvenih profesija, u odnosu prema učenju u realnom radnom okruženju, tj. nastavi u praksi (experiential education - EE), interprofesionalnom obrazovanju (interprofessional education - IPE) i unapređenju nastavničkih kompetencija (teaching competencies development - TCD). Radi daljeg unapređenja u oblasti obrazovanja, za zdravstvene radnike u Srbiji obezbeđeno je kritičko vrednovanje postojećih standarda kvaliteta. Metode. Istraživanje je sprovedeno u okviru projekta Reinforcement of the Framework for Experiential Education in Serbia (ReFEEHS), ko-finansiranog od strane Erasmus+ programa Evropske komisije na četiri univerziteta u Republici Srbiji (Univerzitet u Beogradu, Univerzitet u Kragujevcu, Univerzitet u Nišu i Univerzitet u Novom Sadu). Određene su četiri radne grupe, sa zadatkom razmatranja trenutnih kurikuluma, preporuka i prakse u okviru svake zdravstvene profesije (medicina, farmacija, stomatologija, sestrinstvo), kao i procene njihove usklađenosti sa relevantnim preporukama i praksom u obrazovanju u Evropskoj uniji. Rezultati. U istraživanju je učestvovalo 1 507 ispitanika. Pozitivan stav prema EE, IPE i TCD zabeležen je među svim ispitanicima. Više od 70% ispitanika iskazalo je stav o tome da je potrebno organizovati EE, tj. nastavu u praksi u realnom radnom okruženju, što bi podrazumevalo stručni rad studenata pod nadzorom kompetentnog mentora, ali i interakciju sa bolesnicima, kao i interakciju sa zdravstvenim radnicima. Oko 90% ispitanika podržalo je uključivanje IPE nastavnih aktivnosti u kurikulume; 77% studenata izrazilo je motivisanost da prisustvuju zajedničkim predmetima, dok je čak 93% nastavnika i saradnika iskazalo volju da učestvuju u kreiranju i podučavanju nastavnih jedinica u okviru IPE. Prethodno je samo 20% nastavnika/saradnika pohađalo neki TCD program, dok je čak 75% prepoznalo potrebu za organizacijom tih programa; 90% zdravstvenih radnika smatralo je da su za efikasan mentorski rad u obrazovanju u oblasti zdravstvene nauke potrebne dodatne veštine mentora/kliničkih supervizora. Na osnovu sagledanih rezultata upitnika, date su preporuke za unapređenje visokog obrazovanja u okviru tri obrazovne oblasti budućih zdravstvenih radnika, koje se odnose na kurikulum, studentsku stručnu praksu/klinički staž, nastavno osoblje i regulatorne aspekte. Zaključak. Dobijeni rezultati korišćeni su kao polazna, ali veoma značajna tačka za unapređenje visokog obrazovanja u Srbiji. Sve zainteresovane strane - akademska zajednica, studenti, zdravstveni radnici i regulatorna tela, treba da sarađuju u cilju postizanja unapređenog i savremenog obrazovanja zdravstvenih radnika.",
publisher = "Belgrade : Military Medical Academy",
journal = "Vojnosanitetski pregled",
title = "Health professions education in Serbia: Evaluation and measures for quality improvement through experiential education, interprofessional education and teaching competencies development, Obrazovanje zdravstvenih radnika u Srbiji: procena i mere za unapređenje kvaliteta kroz praksu, interprofesionalno obrazovanje i razvoj nastavničkih kompetencija",
volume = "79",
number = "11",
pages = "1119-1129",
doi = "10.2298/VSP201005089K"
}

Kovačević, M., Odalović, M., Đukić-Ćosić, D., Vasiljević, D., Parojčić, J.,& Tasić, L.. (2022). Health professions education in Serbia: Evaluation and measures for quality improvement through experiential education, interprofessional education and teaching competencies development. in Vojnosanitetski pregled
Belgrade : Military Medical Academy., 79(11), 1119-1129.
https://doi.org/10.2298/VSP201005089K

Kovačević M, Odalović M, Đukić-Ćosić D, Vasiljević D, Parojčić J, Tasić L. Health professions education in Serbia: Evaluation and measures for quality improvement through experiential education, interprofessional education and teaching competencies development. in Vojnosanitetski pregled. 2022;79(11):1119-1129.
doi:10.2298/VSP201005089K .

Kovačević, Milena, Odalović, Marina, Đukić-Ćosić, Danijela, Vasiljević, Dragana, Parojčić, Jelena, Tasić, Ljiljana, "Health professions education in Serbia: Evaluation and measures for quality improvement through experiential education, interprofessional education and teaching competencies development" in Vojnosanitetski pregled, 79, no. 11 (2022):1119-1129,
https://doi.org/10.2298/VSP201005089K . .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4575
AB  - Thin films are relatively new drug forms, which contain one or more active
substances, dispersed or adsorbed on a polymeric carrier (1). The aim of this work was to
evaluate the effects of the preparation and formulation factors on film critical quality
attributes. Films were prepared by solvent-casting and 3D printing of dispersion on a
Ultimaker 2+. Dispersion consisted of hydroxypropylcellulose with or without the addition
of sodium-alginate. Caffeine and ibuprofen were used as model drugs. The films were
characterized in terms of mass, thickness, moisture content (LJ16-Moisture Analizer) and
mechanical characteristics (EZ-LKS-Table-TopMachine). Obtained results indicate that 3D
films had higher mass and thickness compared to casted films, except for
hydroxypropylcellulose/sodium alginate/caffeine sample (37.6 and 59.0 mg/cm2 ; 526 and
642 μm). High content of dispersed substances can cause a change in polymer drying
behavior, which is reflected in film characteristics. Dissolving ibuprofen in the initial
dispersion, led to film increased elasticity and decreased tensile strength, negatively
affecting handling and stickiness of the films prepared by either method. Differences
between methods were most pronounced in films with dispersed caffeine or sodium-
alginate. Sodium-alginate generally decreased, and caffeine increased flexibility. The
preparation process did not affect the moisture content in samples, although the polymer
drying differed between two preparation methods. Increased moisture content was
generally accompanied by decreased flexibility, except for samples with ibuprofen. Obtained
results indicate significant effects of the formulation process and composition on the film
characteristics. Dissolved or dispersed substance content in formulation should be adapted
to the chosen preparation method.
AB  - Tanki oralni filmovi predstavljaju noviji farmaceutski oblik leka, koji sadrži jednu ili
više aktivnih supstanci dispergovanih ili adsorbovanih na polimernom nosaču (1). Cilj ovog
rada bio je ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva
kvaliteta filmova. Filmovi su izrađivani izlivanjem disperzije u kalupe ili metodom 3D štampe
(Ultimaker 2+). Disperzija se sastojala od hidroksipropilceluloze, sa ili bez dodatka natrijum-
alginata. Model aktivne supstance bile su kofein i ibuprofen. Karakterizacija filmova
obuhvatila je određivanje mase, debljine, udela vlage (LJ16-MoistureAnalyzer) i mehaničkih
karakteristika (EZ-LX-Table-TopMachine). Dobijeni rezultati su pokazali da su 3D štampani
filmovi imali veću masu i debljinu u odnosu na izlivene filmove, osim u slučaju uzorka
hidroksipropilceluloza/natrijum-alginat/kofein (37,6 i 59,0 mg/cm 2; 526 i 642 μm). Visok
udeo dispergovanih supstanci u uzorku može uzrokovati promenu u ponašanju polimera
prilikom sušenja što se odražava na karakteristike filmova. Rastvaranje ibuprofena dovelo je
do povećanja elastičnosti i smanjenja zatezne čvrstine filmova u slučaju oba postupka izrade,
što je imalo negativan efekat na lakoću rukovanja i lepljivost. Postupak izrade imao je najveći
uticaj na karakteristike filmova sa natrijum-alginatom i filmova koji su sadržali kofein.
Natrijum-alginat je generalno smanjivao, a kofein povećavao fleksibilnost filmova. Postupak
izrade nije imao uticaj na udeo vlage, iako je sušenje filmova bilo značajno različito kod ova
dva postupka. Povećanje udela vlage uglavnom je pratilo smanjenje fleksibilnosti filmova,
osim kod uzoraka sa ibuprofenom. Dobijeni rezultati ukazuju na značajan uticaj postupka
izrade i sastava formulacije na karakteristike tankih filmova. Udeo rastvorenih ili
dispergovanih supstanci u formulaciji moraju biti prilagođeni odabranom postupku izrade.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into the effects of preparation methods and composition on thin film critical quality attributes
T1  - Ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva kvaliteta tankih oralnih filmova
VL  - 72
IS  - 4 suplement
SP  - S422
EP  - S423
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4575
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Vasiljević, Dragana and Parojčić, Jelena",
year = "2022",
abstract = "Thin films are relatively new drug forms, which contain one or more active
substances, dispersed or adsorbed on a polymeric carrier (1). The aim of this work was to
evaluate the effects of the preparation and formulation factors on film critical quality
attributes. Films were prepared by solvent-casting and 3D printing of dispersion on a
Ultimaker 2+. Dispersion consisted of hydroxypropylcellulose with or without the addition
of sodium-alginate. Caffeine and ibuprofen were used as model drugs. The films were
characterized in terms of mass, thickness, moisture content (LJ16-Moisture Analizer) and
mechanical characteristics (EZ-LKS-Table-TopMachine). Obtained results indicate that 3D
films had higher mass and thickness compared to casted films, except for
hydroxypropylcellulose/sodium alginate/caffeine sample (37.6 and 59.0 mg/cm2 ; 526 and
642 μm). High content of dispersed substances can cause a change in polymer drying
behavior, which is reflected in film characteristics. Dissolving ibuprofen in the initial
dispersion, led to film increased elasticity and decreased tensile strength, negatively
affecting handling and stickiness of the films prepared by either method. Differences
between methods were most pronounced in films with dispersed caffeine or sodium-
alginate. Sodium-alginate generally decreased, and caffeine increased flexibility. The
preparation process did not affect the moisture content in samples, although the polymer
drying differed between two preparation methods. Increased moisture content was
generally accompanied by decreased flexibility, except for samples with ibuprofen. Obtained
results indicate significant effects of the formulation process and composition on the film
characteristics. Dissolved or dispersed substance content in formulation should be adapted
to the chosen preparation method., Tanki oralni filmovi predstavljaju noviji farmaceutski oblik leka, koji sadrži jednu ili
više aktivnih supstanci dispergovanih ili adsorbovanih na polimernom nosaču (1). Cilj ovog
rada bio je ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva
kvaliteta filmova. Filmovi su izrađivani izlivanjem disperzije u kalupe ili metodom 3D štampe
(Ultimaker 2+). Disperzija se sastojala od hidroksipropilceluloze, sa ili bez dodatka natrijum-
alginata. Model aktivne supstance bile su kofein i ibuprofen. Karakterizacija filmova
obuhvatila je određivanje mase, debljine, udela vlage (LJ16-MoistureAnalyzer) i mehaničkih
karakteristika (EZ-LX-Table-TopMachine). Dobijeni rezultati su pokazali da su 3D štampani
filmovi imali veću masu i debljinu u odnosu na izlivene filmove, osim u slučaju uzorka
hidroksipropilceluloza/natrijum-alginat/kofein (37,6 i 59,0 mg/cm 2; 526 i 642 μm). Visok
udeo dispergovanih supstanci u uzorku može uzrokovati promenu u ponašanju polimera
prilikom sušenja što se odražava na karakteristike filmova. Rastvaranje ibuprofena dovelo je
do povećanja elastičnosti i smanjenja zatezne čvrstine filmova u slučaju oba postupka izrade,
što je imalo negativan efekat na lakoću rukovanja i lepljivost. Postupak izrade imao je najveći
uticaj na karakteristike filmova sa natrijum-alginatom i filmova koji su sadržali kofein.
Natrijum-alginat je generalno smanjivao, a kofein povećavao fleksibilnost filmova. Postupak
izrade nije imao uticaj na udeo vlage, iako je sušenje filmova bilo značajno različito kod ova
dva postupka. Povećanje udela vlage uglavnom je pratilo smanjenje fleksibilnosti filmova,
osim kod uzoraka sa ibuprofenom. Dobijeni rezultati ukazuju na značajan uticaj postupka
izrade i sastava formulacije na karakteristike tankih filmova. Udeo rastvorenih ili
dispergovanih supstanci u formulaciji moraju biti prilagođeni odabranom postupku izrade.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into the effects of preparation methods and composition on thin film critical quality attributes, Ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva kvaliteta tankih oralnih filmova",
volume = "72",
number = "4 suplement",
pages = "S422-S423",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4575"
}

Turković, E., Vasiljević, I., Vasiljević, D.,& Parojčić, J.. (2022). An investigation into the effects of preparation methods and composition on thin film critical quality attributes. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S422-S423.
https://hdl.handle.net/21.15107/rcub_farfar_4575

Turković E, Vasiljević I, Vasiljević D, Parojčić J. An investigation into the effects of preparation methods and composition on thin film critical quality attributes. in Arhiv za farmaciju. 2022;72(4 suplement):S422-S423.
https://hdl.handle.net/21.15107/rcub_farfar_4575 .

Turković, Erna, Vasiljević, Ivana, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into the effects of preparation methods and composition on thin film critical quality attributes" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S422-S423,
https://hdl.handle.net/21.15107/rcub_farfar_4575 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
AU  - Vasiljević, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4521
AB  - The estimated prevalence of swallowing problems and dysphagia is 22%, particularly
among pediatric and geriatric population. The drug administration for these individuals is
challenging and efforts are being made to enhance solid dosage forms swallowing. The aim of
this work was to characterize inulin-based puddings as potential vehicula for solid dosage
forms administration. Three marketed instant puddings were prepared according to
instructions provided by the manufacturer (mixing with the appropriate amount of cold
milk, without cooking) and characterized regarding pH value, rheological characteristics and
textural properties (hardness and adhesiveness). The investigated samples differed in terms
of inulin content, as gelling agent (3.3-8%), and aroma (vanilla, chocolate, coco). Generally,
samples exhibited comparable characteristics. pH values of prepared puddings ranged from
6.57 to 6.90. Apparent viscosity values, measured at 50 s -1 , were 4850-16800 mPas,
indicating that puddings belong to class 4 (extremely thick drinks), according to
International Dysphagia Diet Standardization Initiative Framework (1), suitable for patients
suffering from advanced dysphagia. Samples’ hardness values ranged from 54.6 mN (coco
pudding) to 63.9 mN (chocolate pudding), whereas adhesiveness ranged from 30.26 gs (coco
pudding) to 40.64 gs (chocolate pudding), indicating the soft structure and swallowing
suitability, without the need for intense chewing (2). The investigated puddings exhibited
suitable characteristics in terms of viscosity and textural properties for patients with
advanced dysphagia and represent promising approach as vehicula for solid dosage forms
administration in the case of this population.
AB  - Procenjuje se da oko 22% stanovništva ima probleme sa gutanjem i disfagijom, pri
čemu je problem naročito izražen u pedijatrijskoj i gerijatrijskoj populaciji. Primena lekova
kod ovih osoba je otežana i potrebno je razviti odgovarajuće pristupe koji olakšavaju gutanje
čvrstih farmaceutskih oblika. Cilj ovog rada bio je karakterizacija komercijalno dostupnih
instant pudinga, kao potencijalnih vehikuluma za primenu čvrstih farmaceutskih oblika
lekova. Tri komercijalno dostupna instant pudinga su pripremljena prema uputstvu
proizvođača (mešanje sa propisanom zapreminom hladnog mleka, bez kuvanja) i
okarakterisana u pogledu pH vrednosti, reoloških karakteristika i teksture (čvrstina i
adhezivnost). Sastav ispitivanih uzoraka se razlikovao u pogledu udela inulina kao sredstva
za geliranje (3,3-8%) i arome (vanila, čokolada, kokos). Generalno, svojstva ispitivanih
proizvoda bila su uporediva. pH vrednost pripremljenih pudinga bila je 6,57-6,90. Svi uzorci
pokazali su tiksotropno ponašanje. Vrednosti prividnog viskoziteta, izmerene na 50 s -1 , bile
su 4850-16800 mPas, ukazujući da pudinzi spadaju u klasu 4 (veoma guste tečnosti) prema
Smernicama Inicijative za međunarodnu standardizaciju ishrane u disfagiji (1) i da su pogodni
za pacijente sa uznapredovalom disfagijom. Čvrstina uzoraka bila je u rasponu od 54,6 mN
(puding od kokosa) do 63,9 mN (puding od čokolade), a adhezivnost od 30,26 gs (puding od
kokosa) do 40,64 gs (puding od čokolade), ukazujući na meku strukturu i pogodnost za
gutanje bez intenzivnog žvakanja (2). Ispitivani pudinzi pokazali su pogodni viskozitet i
teksturu za primenu kod pacijenata sa uznapredovalom disfagijom i predstavljaju
obećavajući pristup za primenu čvrstih farmaceutskih oblika kod ove populacije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia
T1  - Ispitivanje instant pudinga kao potencijalnih vehikuluma za primenu lekova kod pacijenata sa disfagijom
VL  - 72
IS  - 4 suplement
SP  - S237
EP  - S238
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4521
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena and Vasiljević, Dragana",
year = "2022",
abstract = "The estimated prevalence of swallowing problems and dysphagia is 22%, particularly
among pediatric and geriatric population. The drug administration for these individuals is
challenging and efforts are being made to enhance solid dosage forms swallowing. The aim of
this work was to characterize inulin-based puddings as potential vehicula for solid dosage
forms administration. Three marketed instant puddings were prepared according to
instructions provided by the manufacturer (mixing with the appropriate amount of cold
milk, without cooking) and characterized regarding pH value, rheological characteristics and
textural properties (hardness and adhesiveness). The investigated samples differed in terms
of inulin content, as gelling agent (3.3-8%), and aroma (vanilla, chocolate, coco). Generally,
samples exhibited comparable characteristics. pH values of prepared puddings ranged from
6.57 to 6.90. Apparent viscosity values, measured at 50 s -1 , were 4850-16800 mPas,
indicating that puddings belong to class 4 (extremely thick drinks), according to
International Dysphagia Diet Standardization Initiative Framework (1), suitable for patients
suffering from advanced dysphagia. Samples’ hardness values ranged from 54.6 mN (coco
pudding) to 63.9 mN (chocolate pudding), whereas adhesiveness ranged from 30.26 gs (coco
pudding) to 40.64 gs (chocolate pudding), indicating the soft structure and swallowing
suitability, without the need for intense chewing (2). The investigated puddings exhibited
suitable characteristics in terms of viscosity and textural properties for patients with
advanced dysphagia and represent promising approach as vehicula for solid dosage forms
administration in the case of this population., Procenjuje se da oko 22% stanovništva ima probleme sa gutanjem i disfagijom, pri
čemu je problem naročito izražen u pedijatrijskoj i gerijatrijskoj populaciji. Primena lekova
kod ovih osoba je otežana i potrebno je razviti odgovarajuće pristupe koji olakšavaju gutanje
čvrstih farmaceutskih oblika. Cilj ovog rada bio je karakterizacija komercijalno dostupnih
instant pudinga, kao potencijalnih vehikuluma za primenu čvrstih farmaceutskih oblika
lekova. Tri komercijalno dostupna instant pudinga su pripremljena prema uputstvu
proizvođača (mešanje sa propisanom zapreminom hladnog mleka, bez kuvanja) i
okarakterisana u pogledu pH vrednosti, reoloških karakteristika i teksture (čvrstina i
adhezivnost). Sastav ispitivanih uzoraka se razlikovao u pogledu udela inulina kao sredstva
za geliranje (3,3-8%) i arome (vanila, čokolada, kokos). Generalno, svojstva ispitivanih
proizvoda bila su uporediva. pH vrednost pripremljenih pudinga bila je 6,57-6,90. Svi uzorci
pokazali su tiksotropno ponašanje. Vrednosti prividnog viskoziteta, izmerene na 50 s -1 , bile
su 4850-16800 mPas, ukazujući da pudinzi spadaju u klasu 4 (veoma guste tečnosti) prema
Smernicama Inicijative za međunarodnu standardizaciju ishrane u disfagiji (1) i da su pogodni
za pacijente sa uznapredovalom disfagijom. Čvrstina uzoraka bila je u rasponu od 54,6 mN
(puding od kokosa) do 63,9 mN (puding od čokolade), a adhezivnost od 30,26 gs (puding od
kokosa) do 40,64 gs (puding od čokolade), ukazujući na meku strukturu i pogodnost za
gutanje bez intenzivnog žvakanja (2). Ispitivani pudinzi pokazali su pogodni viskozitet i
teksturu za primenu kod pacijenata sa uznapredovalom disfagijom i predstavljaju
obećavajući pristup za primenu čvrstih farmaceutskih oblika kod ove populacije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia, Ispitivanje instant pudinga kao potencijalnih vehikuluma za primenu lekova kod pacijenata sa disfagijom",
volume = "72",
number = "4 suplement",
pages = "S237-S238",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4521"
}

Vasiljević, I., Turković, E., Parojčić, J.,& Vasiljević, D.. (2022). An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S237-S238.
https://hdl.handle.net/21.15107/rcub_farfar_4521

Vasiljević I, Turković E, Parojčić J, Vasiljević D. An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia. in Arhiv za farmaciju. 2022;72(4 suplement):S237-S238.
https://hdl.handle.net/21.15107/rcub_farfar_4521 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, Vasiljević, Dragana, "An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S237-S238,
https://hdl.handle.net/21.15107/rcub_farfar_4521 .

TY  - CONF
AU  - Vasiljević, Dragana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4668
AB  - A demand for natural cosmetic products is increasing, especially in the EU countries
and the rest of the world, as the consumer awareness has increased for the preservation of
the environment and natural resources, but above all with the belief that these products are
safe and “healthy”. The current regulations on cosmetic products in the EU and the Republic
of Serbia do not recognize organic and natural cosmetic products as a special category, so
these products must meet all the requirements of these regulations in terms of quality,
efficacy and safety. However, due to the great interest of consumers and manufacturers,
there is a need to adopt special (additional) requirements for organic and natural cosmetic
products. Although, for now, there are no mandatory international regulations in this area,
the most important standards are: COSMOS, NATRUE and ISO 16128 (1-3). Despite certain
differences, these standards stand out in terms of their main objectives: promoting the use of
organic agriculture products, and respecting biodiversity, responsible use of natural
resources and respecting the environment, using processing and manufacturing that are
clean and respectful of human health and the environment, and integrating and developing
the concept of "Green Chemistry" (3).
Organic and natural cosmetic products are made from selected raw materials, most
often of plant origin, that are allowed for their production and processed with permitted
physical and chemical processes. The use of ingredients of animal origin is also allowed, if
that ingredient is produced by an animal naturally (it must not be part of an animal), such as
lanolin, beeswax, honey. The use of the ingredient from petrochemical origin (liquid and
solid paraffin, petrolatum/ white soft paraffin), silicone oils, nanomaterials, ingredients that
are GMOs, synthetic fragrances, dyes and preservatives are forbidden (1).
Great attention is paid to the packaging of organic and natural cosmetic products. The
amount of packaging material should be reduced to the minimum necessary, and the amount
of packaging material that can be reused or recycled should be increased. The use of plastic
materials (PVC, polystyrene, etc.), which are not biodegradable is forbidden (3).
Today, the quality, efficacy and safety of all cosmetic products are taken for granted.
However, the use of organic and natural cosmetic products has a great impact on the
preservation of the environment and natural resources. The adoption of binding
international legal regulations in this area is very important.
AB  - Povećana potražnja za prirodnim i organskim kozmetičkim proizvodima, u zemljama
EU i u svetu, posledica je porasta svesti potrošača za očuvanjem životne sredine i prirodnih
resursa, ali i verovanjem da su ti proizvodi „zdraviji“ i bezbedniji u poređenju sa
konvencionalnim kozmetičkim proizvodima. Važeći zakonski propisi o kozmetičkim
proizvodima u zemljama EU i Republici Srbiji ne prepoznaju organske i prirodne kozmetičke
proizvode kao posebnu kategoriju, pa i ovi proizvodi moraju zadovoljiti sve zahteve
zakonskih propisa u pogledu kvaliteta, efikasnosti i bezbednosti. Međutim, zbog velike
zainteresovanosti potrošača i proizvođača nametnula se potreba za usvajanjem posebnih
(dodatnih) zahteva za organske i prirodne kozmetičke proizvode. Iako, za sada, ne postoje
obavezujući međunarodni zakonski propisi u ovoj oblasti, najznačajnijim se mogu smatrati
standardi: COSMOS (od 2010. godine), NATRUE (od 2007. godine) i ISO 16128 (1-3). Prvi
deo ISO standarda 16128 (Definicije sastojaka) usvojen je 2016. godine, a drugi (Kriterijumi
za sastojke i proizvode) 2017. godine. Iako se očekivalo da će usvajanje ISO standarda bliže
urediti ovu oblast, predstavnici vodećih evropskih udruženja za prirodne i organske
kozmetičke proizvode navode da ISO standard 16128 ima brojne nedostatke (1). I pored
određenih razlika, navedeni standardi kao svoje glavne ciljeve ističu odgovorno korišćenje
prirodnih resursa i poštovanje životne sredine, korišćenje postupaka koji su „čisti“ i koji
poštuju zdravlje ljudi i životnu sredinu, kao i integrisanje i razvoj koncepta "Zelene hemije"
(3).
Organski i prirodni kozmetički proizvodi se izrađuju od odabranih sirovina, najčešće
biljnog porekla (npr. biljni ekstrakti, biljna ulja, masti i voskovi, masne kiseline i masni
alkoholi, etarska ulja i dr.) koje su dozvoljene za njihovu izradu i obrađene dozvoljenim
fizičkim i hemijskim postupcima. Dozvoljena je i upotreba sastojaka životinjskog porekla,
ukoliko je taj sastojak proizvod životinje (npr. lanolin, pčelinji vosak, med), a ne sme biti deo
životinje. Zabranjena je upotreba sirovina dobijenih iz nafte (tečni i čvrsti parafin,
petrolatum/vazelin), silikonskih ulja, nanomaterijala, genetski modifikovanih sirovina,
sintetičkih mirisa, boja i konzervanasa (1).
Pakovanju organskih i prirodnih kozmetičkih proizvoda se posvećuje velika pažnja.
Količinu pakovnog materijala treba svesti na neophodni minimum, a treba povećati količinu
materijala za pakovanje koji se može ponovo upotrebiti ili reciklirati. Zabranjena je upotreba
plastičnih materijala (PVC, polistiren i dr.), koji nisu biodegradabilni (3).
Danas se kvalitet, efikasnost i bezbednost svih kozmetičkih proizvoda podrazumeva.
Ali, upotreba organskih i prirodnih kozmetičkih proizvoda ima veliki uticaj na očuvanje
životne sredine i prirodnih resursa. Zato je usvajanje obavezujućih međunarodnih zakonskih
propisa u ovoj oblasti od izuzetnog značaja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Organic and natural cosmetic products ‐ who benefits the most?
T1  - Organski i prirodni kozmetički proizvodi ‐ ko ima najviše koristi od njih?
VL  - 71
IS  - 5 suplement
SP  - S26
EP  - S27
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4668
ER  - 

@conference{
author = "Vasiljević, Dragana",
year = "2021",
abstract = "A demand for natural cosmetic products is increasing, especially in the EU countries
and the rest of the world, as the consumer awareness has increased for the preservation of
the environment and natural resources, but above all with the belief that these products are
safe and “healthy”. The current regulations on cosmetic products in the EU and the Republic
of Serbia do not recognize organic and natural cosmetic products as a special category, so
these products must meet all the requirements of these regulations in terms of quality,
efficacy and safety. However, due to the great interest of consumers and manufacturers,
there is a need to adopt special (additional) requirements for organic and natural cosmetic
products. Although, for now, there are no mandatory international regulations in this area,
the most important standards are: COSMOS, NATRUE and ISO 16128 (1-3). Despite certain
differences, these standards stand out in terms of their main objectives: promoting the use of
organic agriculture products, and respecting biodiversity, responsible use of natural
resources and respecting the environment, using processing and manufacturing that are
clean and respectful of human health and the environment, and integrating and developing
the concept of "Green Chemistry" (3).
Organic and natural cosmetic products are made from selected raw materials, most
often of plant origin, that are allowed for their production and processed with permitted
physical and chemical processes. The use of ingredients of animal origin is also allowed, if
that ingredient is produced by an animal naturally (it must not be part of an animal), such as
lanolin, beeswax, honey. The use of the ingredient from petrochemical origin (liquid and
solid paraffin, petrolatum/ white soft paraffin), silicone oils, nanomaterials, ingredients that
are GMOs, synthetic fragrances, dyes and preservatives are forbidden (1).
Great attention is paid to the packaging of organic and natural cosmetic products. The
amount of packaging material should be reduced to the minimum necessary, and the amount
of packaging material that can be reused or recycled should be increased. The use of plastic
materials (PVC, polystyrene, etc.), which are not biodegradable is forbidden (3).
Today, the quality, efficacy and safety of all cosmetic products are taken for granted.
However, the use of organic and natural cosmetic products has a great impact on the
preservation of the environment and natural resources. The adoption of binding
international legal regulations in this area is very important., Povećana potražnja za prirodnim i organskim kozmetičkim proizvodima, u zemljama
EU i u svetu, posledica je porasta svesti potrošača za očuvanjem životne sredine i prirodnih
resursa, ali i verovanjem da su ti proizvodi „zdraviji“ i bezbedniji u poređenju sa
konvencionalnim kozmetičkim proizvodima. Važeći zakonski propisi o kozmetičkim
proizvodima u zemljama EU i Republici Srbiji ne prepoznaju organske i prirodne kozmetičke
proizvode kao posebnu kategoriju, pa i ovi proizvodi moraju zadovoljiti sve zahteve
zakonskih propisa u pogledu kvaliteta, efikasnosti i bezbednosti. Međutim, zbog velike
zainteresovanosti potrošača i proizvođača nametnula se potreba za usvajanjem posebnih
(dodatnih) zahteva za organske i prirodne kozmetičke proizvode. Iako, za sada, ne postoje
obavezujući međunarodni zakonski propisi u ovoj oblasti, najznačajnijim se mogu smatrati
standardi: COSMOS (od 2010. godine), NATRUE (od 2007. godine) i ISO 16128 (1-3). Prvi
deo ISO standarda 16128 (Definicije sastojaka) usvojen je 2016. godine, a drugi (Kriterijumi
za sastojke i proizvode) 2017. godine. Iako se očekivalo da će usvajanje ISO standarda bliže
urediti ovu oblast, predstavnici vodećih evropskih udruženja za prirodne i organske
kozmetičke proizvode navode da ISO standard 16128 ima brojne nedostatke (1). I pored
određenih razlika, navedeni standardi kao svoje glavne ciljeve ističu odgovorno korišćenje
prirodnih resursa i poštovanje životne sredine, korišćenje postupaka koji su „čisti“ i koji
poštuju zdravlje ljudi i životnu sredinu, kao i integrisanje i razvoj koncepta "Zelene hemije"
(3).
Organski i prirodni kozmetički proizvodi se izrađuju od odabranih sirovina, najčešće
biljnog porekla (npr. biljni ekstrakti, biljna ulja, masti i voskovi, masne kiseline i masni
alkoholi, etarska ulja i dr.) koje su dozvoljene za njihovu izradu i obrađene dozvoljenim
fizičkim i hemijskim postupcima. Dozvoljena je i upotreba sastojaka životinjskog porekla,
ukoliko je taj sastojak proizvod životinje (npr. lanolin, pčelinji vosak, med), a ne sme biti deo
životinje. Zabranjena je upotreba sirovina dobijenih iz nafte (tečni i čvrsti parafin,
petrolatum/vazelin), silikonskih ulja, nanomaterijala, genetski modifikovanih sirovina,
sintetičkih mirisa, boja i konzervanasa (1).
Pakovanju organskih i prirodnih kozmetičkih proizvoda se posvećuje velika pažnja.
Količinu pakovnog materijala treba svesti na neophodni minimum, a treba povećati količinu
materijala za pakovanje koji se može ponovo upotrebiti ili reciklirati. Zabranjena je upotreba
plastičnih materijala (PVC, polistiren i dr.), koji nisu biodegradabilni (3).
Danas se kvalitet, efikasnost i bezbednost svih kozmetičkih proizvoda podrazumeva.
Ali, upotreba organskih i prirodnih kozmetičkih proizvoda ima veliki uticaj na očuvanje
životne sredine i prirodnih resursa. Zato je usvajanje obavezujućih međunarodnih zakonskih
propisa u ovoj oblasti od izuzetnog značaja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Organic and natural cosmetic products ‐ who benefits the most?, Organski i prirodni kozmetički proizvodi ‐ ko ima najviše koristi od njih?",
volume = "71",
number = "5 suplement",
pages = "S26-S27",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4668"
}

Vasiljević, D.. (2021). Organic and natural cosmetic products ‐ who benefits the most?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S26-S27.
https://hdl.handle.net/21.15107/rcub_farfar_4668

Vasiljević D. Organic and natural cosmetic products ‐ who benefits the most?. in Arhiv za farmaciju. 2021;71(5 suplement):S26-S27.
https://hdl.handle.net/21.15107/rcub_farfar_4668 .

Vasiljević, Dragana, "Organic and natural cosmetic products ‐ who benefits the most?" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S26-S27,
https://hdl.handle.net/21.15107/rcub_farfar_4668 .

TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Obradović, Nataša
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3819
AB  - Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.
PB  - MDPI
T2  - Pharmaceutics
T1  - An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
VL  - 13
IS  - 4
DO  - 10.3390/pharmaceutics13040468
ER  - 

@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Obradović, Nataša and Vasiljević, Dragana and Parojčić, Jelena",
year = "2021",
abstract = "Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films",
volume = "13",
number = "4",
doi = "10.3390/pharmaceutics13040468"
}

Turković, E., Vasiljević, I., Drašković, M., Obradović, N., Vasiljević, D.,& Parojčić, J.. (2021). An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics
MDPI., 13(4).
https://doi.org/10.3390/pharmaceutics13040468

Turković E, Vasiljević I, Drašković M, Obradović N, Vasiljević D, Parojčić J. An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics. 2021;13(4).
doi:10.3390/pharmaceutics13040468 .

Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Obradović, Nataša, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films" in Pharmaceutics, 13, no. 4 (2021),
https://doi.org/10.3390/pharmaceutics13040468 . .

TY  - JOUR
AU  - Krkobabić, Mirjana
AU  - Medarević, Đorđe
AU  - Pešić, Nikola
AU  - Vasiljević, Dragana
AU  - Ivković, Branka
AU  - Ibrić, Svetlana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3710
AB  - Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.
PB  - MDPI AG
T2  - Pharmaceutics
T1  - Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions
VL  - 12
IS  - 9
SP  - 1
EP  - 17
DO  - 10.3390/pharmaceutics12090833
ER  - 

@article{
author = "Krkobabić, Mirjana and Medarević, Đorđe and Pešić, Nikola and Vasiljević, Dragana and Ivković, Branka and Ibrić, Svetlana",
year = "2020",
abstract = "Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.",
publisher = "MDPI AG",
journal = "Pharmaceutics",
title = "Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions",
volume = "12",
number = "9",
pages = "1-17",
doi = "10.3390/pharmaceutics12090833"
}

Krkobabić, M., Medarević, Đ., Pešić, N., Vasiljević, D., Ivković, B.,& Ibrić, S.. (2020). Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions. in Pharmaceutics
MDPI AG., 12(9), 1-17.
https://doi.org/10.3390/pharmaceutics12090833

Krkobabić M, Medarević Đ, Pešić N, Vasiljević D, Ivković B, Ibrić S. Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions. in Pharmaceutics. 2020;12(9):1-17.
doi:10.3390/pharmaceutics12090833 .

Krkobabić, Mirjana, Medarević, Đorđe, Pešić, Nikola, Vasiljević, Dragana, Ivković, Branka, Ibrić, Svetlana, "Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions" in Pharmaceutics, 12, no. 9 (2020):1-17,
https://doi.org/10.3390/pharmaceutics12090833 . .

TY  - JOUR
AU  - Osmanović Omerdić, Ehlimana
AU  - Alagić-Džambić, Larisa
AU  - Krstić, Marko
AU  - Pašić-Kulenović, Maja
AU  - Odović, Jadranka
AU  - Vasiljević, Dragana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3637
AB  - Solid dispersions were prepared via a solvent evaporation method, employing ethanol (96%, v/v) as solvent, with three different polymers as carrier: povidone, copovidone, and poloxamer 407. Previously developed reversed-phase HPLC (RP-HPLC) methods were modified and used for the simultaneous determination of acetylsalicylic acid and clopidogrel bisulfate and after release from solid dispersions. Chromatography was carried out on a C-18 column, with a mobile phase of acetonitrile-methanol-phosphate buffer pH 3.0, UV detection at 240 nm, and a run time of 6 min. The method was validated according to International Conference of Harmonisation guidelines and validation included specificity, accuracy, precision, linearity, robustness, limit of detection (LOD), and limit of quantification (LOQ). The method is specific for determination of acetylsalicylic acid and clopidogrel bisulfate. The linearity was provided in the concentration range 0.0275-0.1375 mg/mL for acetylsalicylic acid and 0.0200-0.1000 mg/mL for clopidogrel bisulfate, with a correlation coefficient (R2 value) of 0.9999 for both active pharmaceutical ingredients (APIs). Accuracy was confirmed by calculated recoveries for acetylsalicylic acid (98.6-101.0%) and clopidogrel bisulfate (100.0-101.6%). The intra-day and the inter-day precision-calculated relative standard deviations are less than 1%, which indicates high precision of the method. The limits of detection and quantification for acetylsalicylic acid were 0.0004 and 0.0012 mg/mL, and for clopidogrel bisulfate 0.0002 mg/mL and 0.0007 mg/mL, respectively. Small variations in chromatographic conditions did not significantly affect qualitative and quantitative system responses, which proved robustness of method. The proposed RP-HPLC method was applied for simultaneous determination of clopidogrel bisulfate and acetylsalicylic acid from solid dispersions.
PB  - MDPI AG
T2  - Applied Sciences (Switzerland)
T1  - In vitro dissolution study of acetylsalicylic acid and clopidogrel bisulfate solid dispersions: Validation of the RP-HPLC method for simultaneous analysis
VL  - 10
IS  - 14
DO  - 10.3390/app10144792
ER  - 

@article{
author = "Osmanović Omerdić, Ehlimana and Alagić-Džambić, Larisa and Krstić, Marko and Pašić-Kulenović, Maja and Odović, Jadranka and Vasiljević, Dragana",
year = "2020",
abstract = "Solid dispersions were prepared via a solvent evaporation method, employing ethanol (96%, v/v) as solvent, with three different polymers as carrier: povidone, copovidone, and poloxamer 407. Previously developed reversed-phase HPLC (RP-HPLC) methods were modified and used for the simultaneous determination of acetylsalicylic acid and clopidogrel bisulfate and after release from solid dispersions. Chromatography was carried out on a C-18 column, with a mobile phase of acetonitrile-methanol-phosphate buffer pH 3.0, UV detection at 240 nm, and a run time of 6 min. The method was validated according to International Conference of Harmonisation guidelines and validation included specificity, accuracy, precision, linearity, robustness, limit of detection (LOD), and limit of quantification (LOQ). The method is specific for determination of acetylsalicylic acid and clopidogrel bisulfate. The linearity was provided in the concentration range 0.0275-0.1375 mg/mL for acetylsalicylic acid and 0.0200-0.1000 mg/mL for clopidogrel bisulfate, with a correlation coefficient (R2 value) of 0.9999 for both active pharmaceutical ingredients (APIs). Accuracy was confirmed by calculated recoveries for acetylsalicylic acid (98.6-101.0%) and clopidogrel bisulfate (100.0-101.6%). The intra-day and the inter-day precision-calculated relative standard deviations are less than 1%, which indicates high precision of the method. The limits of detection and quantification for acetylsalicylic acid were 0.0004 and 0.0012 mg/mL, and for clopidogrel bisulfate 0.0002 mg/mL and 0.0007 mg/mL, respectively. Small variations in chromatographic conditions did not significantly affect qualitative and quantitative system responses, which proved robustness of method. The proposed RP-HPLC method was applied for simultaneous determination of clopidogrel bisulfate and acetylsalicylic acid from solid dispersions.",
publisher = "MDPI AG",
journal = "Applied Sciences (Switzerland)",
title = "In vitro dissolution study of acetylsalicylic acid and clopidogrel bisulfate solid dispersions: Validation of the RP-HPLC method for simultaneous analysis",
volume = "10",
number = "14",
doi = "10.3390/app10144792"
}

Osmanović Omerdić, E., Alagić-Džambić, L., Krstić, M., Pašić-Kulenović, M., Odović, J.,& Vasiljević, D.. (2020). In vitro dissolution study of acetylsalicylic acid and clopidogrel bisulfate solid dispersions: Validation of the RP-HPLC method for simultaneous analysis. in Applied Sciences (Switzerland)
MDPI AG., 10(14).
https://doi.org/10.3390/app10144792

Osmanović Omerdić E, Alagić-Džambić L, Krstić M, Pašić-Kulenović M, Odović J, Vasiljević D. In vitro dissolution study of acetylsalicylic acid and clopidogrel bisulfate solid dispersions: Validation of the RP-HPLC method for simultaneous analysis. in Applied Sciences (Switzerland). 2020;10(14).
doi:10.3390/app10144792 .

Osmanović Omerdić, Ehlimana, Alagić-Džambić, Larisa, Krstić, Marko, Pašić-Kulenović, Maja, Odović, Jadranka, Vasiljević, Dragana, "In vitro dissolution study of acetylsalicylic acid and clopidogrel bisulfate solid dispersions: Validation of the RP-HPLC method for simultaneous analysis" in Applied Sciences (Switzerland), 10, no. 14 (2020),
https://doi.org/10.3390/app10144792 . .

TY  - JOUR
AU  - Ćetković, Zora
AU  - Cvijić, Sandra
AU  - Vasiljević, Dragana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3457
AB  - Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV). The purpose of this study was to formulate advantageous lipid-based drug delivery systems for pH-controlled release of SV using polymethacrylate polymers (Eudragit®) as carriers. Liquid SV-loaded self-microemulsifying drug delivery systems (SMEDDS), composed of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, or propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (PEG-15 hydroxystearate), were characterized in terms of emulsification time, robustness to dilution, and droplet size. To enable targeted SV release at desired pH, the liquid SMEDDS were mixed with solid carriers, Eudragit® L100 and/or Eudragit® S100. The resulting gel-like lipid-based drug delivery systems were transparent and ductile, and exhibited viscoelastic rheological properties. In vitro dissolution data indicated sustained SV release in pH medium corresponding to distal ileum. The simulation results revealed that sustained SV release from the designed systems is expected to increase SV bioavailability. Overall, our results demonstrate that sustained-release drug delivery systems, composed of liquid SMEDDS and polymethacrylate carriers (Eudragit® polymers), have the potential to enhance oral bioavailability of drugs with preferred absorption site in the pH medium corresponding to distal ileum.
PB  - Elsevier
T2  - Journal of Drug Delivery Science and Technology
T1  - Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin
VL  - 53
SP  - 1
EP  - 9
DO  - 10.1016/j.jddst.2019.101222
ER  - 

@article{
author = "Ćetković, Zora and Cvijić, Sandra and Vasiljević, Dragana",
year = "2019",
abstract = "Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV). The purpose of this study was to formulate advantageous lipid-based drug delivery systems for pH-controlled release of SV using polymethacrylate polymers (Eudragit®) as carriers. Liquid SV-loaded self-microemulsifying drug delivery systems (SMEDDS), composed of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, or propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (PEG-15 hydroxystearate), were characterized in terms of emulsification time, robustness to dilution, and droplet size. To enable targeted SV release at desired pH, the liquid SMEDDS were mixed with solid carriers, Eudragit® L100 and/or Eudragit® S100. The resulting gel-like lipid-based drug delivery systems were transparent and ductile, and exhibited viscoelastic rheological properties. In vitro dissolution data indicated sustained SV release in pH medium corresponding to distal ileum. The simulation results revealed that sustained SV release from the designed systems is expected to increase SV bioavailability. Overall, our results demonstrate that sustained-release drug delivery systems, composed of liquid SMEDDS and polymethacrylate carriers (Eudragit® polymers), have the potential to enhance oral bioavailability of drugs with preferred absorption site in the pH medium corresponding to distal ileum.",
publisher = "Elsevier",
journal = "Journal of Drug Delivery Science and Technology",
title = "Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin",
volume = "53",
pages = "1-9",
doi = "10.1016/j.jddst.2019.101222"
}

Ćetković, Z., Cvijić, S.,& Vasiljević, D.. (2019). Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin. in Journal of Drug Delivery Science and Technology
Elsevier., 53, 1-9.
https://doi.org/10.1016/j.jddst.2019.101222

Ćetković Z, Cvijić S, Vasiljević D. Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin. in Journal of Drug Delivery Science and Technology. 2019;53:1-9.
doi:10.1016/j.jddst.2019.101222 .

Ćetković, Zora, Cvijić, Sandra, Vasiljević, Dragana, "Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin" in Journal of Drug Delivery Science and Technology, 53 (2019):1-9,
https://doi.org/10.1016/j.jddst.2019.101222 . .

TY  - JOUR
AU  - Cetković, Zora
AU  - Cvijić, Sandra
AU  - Vasiljević, Dragana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3178
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3430
AB  - Objective: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also to identify the optimal place in the gastrointestinal (GI) tract for the release of SV using coupled in vitro/in silico approach. Significance: In comparison to other published results, this study considered the extensive pre-systemic clearance of SV, which could significantly decrease its systemic and hepatic bioavailability if SV is delivered into the small intestine. Methods: SV-loaded SMEDDS were formulated using various proportions of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (polysorbate 80) and subjected to characterization, and physiologically-based pharmacokinetic (PBPK) modeling. Results: According to the in vitro results, the selected SMEDDS consisted of 10.0% PEG 300 oleic glycerides, 67.5% PEG 400 caprylic/capric glycerides, and 22.5% polysorbate 80. The use of acid-resistant capsules filled with SV-loaded SMEDDS was found helpful in protecting the drug against early degradation in proximal parts of the GI tract, however, in silico simulations indicated that pH-controlled drug release system that dissolve in the distal parts of the intestine might further improve SV bioavailability (up to 7.20%). Conclusion: The obtained results suggested that combined strategy for the improvement of SV bioavailability should comprise solubility enhancement and delayed drug release. The developed SV-specific PBPK model could potentially be used to assess the influence of formulation factors on drug absorption and disposition when developing SV oral dosage forms.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems
VL  - 44
IS  - 5
SP  - 849
EP  - 860
DO  - 10.1080/03639045.2017.1414835
ER  - 

@article{
author = "Cetković, Zora and Cvijić, Sandra and Vasiljević, Dragana",
year = "2018",
abstract = "Objective: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also to identify the optimal place in the gastrointestinal (GI) tract for the release of SV using coupled in vitro/in silico approach. Significance: In comparison to other published results, this study considered the extensive pre-systemic clearance of SV, which could significantly decrease its systemic and hepatic bioavailability if SV is delivered into the small intestine. Methods: SV-loaded SMEDDS were formulated using various proportions of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (polysorbate 80) and subjected to characterization, and physiologically-based pharmacokinetic (PBPK) modeling. Results: According to the in vitro results, the selected SMEDDS consisted of 10.0% PEG 300 oleic glycerides, 67.5% PEG 400 caprylic/capric glycerides, and 22.5% polysorbate 80. The use of acid-resistant capsules filled with SV-loaded SMEDDS was found helpful in protecting the drug against early degradation in proximal parts of the GI tract, however, in silico simulations indicated that pH-controlled drug release system that dissolve in the distal parts of the intestine might further improve SV bioavailability (up to 7.20%). Conclusion: The obtained results suggested that combined strategy for the improvement of SV bioavailability should comprise solubility enhancement and delayed drug release. The developed SV-specific PBPK model could potentially be used to assess the influence of formulation factors on drug absorption and disposition when developing SV oral dosage forms.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems",
volume = "44",
number = "5",
pages = "849-860",
doi = "10.1080/03639045.2017.1414835"
}

Cetković, Z., Cvijić, S.,& Vasiljević, D.. (2018). In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 44(5), 849-860.
https://doi.org/10.1080/03639045.2017.1414835

Cetković Z, Cvijić S, Vasiljević D. In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems. in Drug Development and Industrial Pharmacy. 2018;44(5):849-860.
doi:10.1080/03639045.2017.1414835 .

Cetković, Zora, Cvijić, Sandra, Vasiljević, Dragana, "In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems" in Drug Development and Industrial Pharmacy, 44, no. 5 (2018):849-860,
https://doi.org/10.1080/03639045.2017.1414835 . .

TY  - JOUR
AU  - Cetković, Zora
AU  - Cvijić, Sandra
AU  - Vasiljević, Dragana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3178
AB  - Objective: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also to identify the optimal place in the gastrointestinal (GI) tract for the release of SV using coupled in vitro/in silico approach. Significance: In comparison to other published results, this study considered the extensive pre-systemic clearance of SV, which could significantly decrease its systemic and hepatic bioavailability if SV is delivered into the small intestine. Methods: SV-loaded SMEDDS were formulated using various proportions of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (polysorbate 80) and subjected to characterization, and physiologically-based pharmacokinetic (PBPK) modeling. Results: According to the in vitro results, the selected SMEDDS consisted of 10.0% PEG 300 oleic glycerides, 67.5% PEG 400 caprylic/capric glycerides, and 22.5% polysorbate 80. The use of acid-resistant capsules filled with SV-loaded SMEDDS was found helpful in protecting the drug against early degradation in proximal parts of the GI tract, however, in silico simulations indicated that pH-controlled drug release system that dissolve in the distal parts of the intestine might further improve SV bioavailability (up to 7.20%). Conclusion: The obtained results suggested that combined strategy for the improvement of SV bioavailability should comprise solubility enhancement and delayed drug release. The developed SV-specific PBPK model could potentially be used to assess the influence of formulation factors on drug absorption and disposition when developing SV oral dosage forms.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems
VL  - 44
IS  - 5
SP  - 849
EP  - 860
DO  - 10.1080/03639045.2017.1414835
ER  - 

@article{
author = "Cetković, Zora and Cvijić, Sandra and Vasiljević, Dragana",
year = "2018",
abstract = "Objective: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also to identify the optimal place in the gastrointestinal (GI) tract for the release of SV using coupled in vitro/in silico approach. Significance: In comparison to other published results, this study considered the extensive pre-systemic clearance of SV, which could significantly decrease its systemic and hepatic bioavailability if SV is delivered into the small intestine. Methods: SV-loaded SMEDDS were formulated using various proportions of oils (PEG 300 oleic glycerides, propylene glycol monocaprylate, propylene glycol monolaurate), surfactant (PEG 400 caprylic/capric glycerides) and cosurfactant (polysorbate 80) and subjected to characterization, and physiologically-based pharmacokinetic (PBPK) modeling. Results: According to the in vitro results, the selected SMEDDS consisted of 10.0% PEG 300 oleic glycerides, 67.5% PEG 400 caprylic/capric glycerides, and 22.5% polysorbate 80. The use of acid-resistant capsules filled with SV-loaded SMEDDS was found helpful in protecting the drug against early degradation in proximal parts of the GI tract, however, in silico simulations indicated that pH-controlled drug release system that dissolve in the distal parts of the intestine might further improve SV bioavailability (up to 7.20%). Conclusion: The obtained results suggested that combined strategy for the improvement of SV bioavailability should comprise solubility enhancement and delayed drug release. The developed SV-specific PBPK model could potentially be used to assess the influence of formulation factors on drug absorption and disposition when developing SV oral dosage forms.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems",
volume = "44",
number = "5",
pages = "849-860",
doi = "10.1080/03639045.2017.1414835"
}

Cetković, Z., Cvijić, S.,& Vasiljević, D.. (2018). In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 44(5), 849-860.
https://doi.org/10.1080/03639045.2017.1414835

Cetković Z, Cvijić S, Vasiljević D. In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems. in Drug Development and Industrial Pharmacy. 2018;44(5):849-860.
doi:10.1080/03639045.2017.1414835 .

Cetković, Zora, Cvijić, Sandra, Vasiljević, Dragana, "In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems" in Drug Development and Industrial Pharmacy, 44, no. 5 (2018):849-860,
https://doi.org/10.1080/03639045.2017.1414835 . .

TY  - JOUR
AU  - Krstić, Marko
AU  - Lukić, I
AU  - Bušatlić, A
AU  - Lazarević, N
AU  - Vasiljević, Dragana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3130
AB  - Solid dispersions are defined as dispersions of one or more active pharmaceutical ingredients in inert solid-state carriers. They are made with the aim to increase solubility and the dissolution rate of low solubility active pharmaceutical ingredients, with the subsequent increase in their bioavailability. The aim of this study was the development and optimization of solid dispersion formulations with carbamazepine, using D-optimal experimental design, in order to increase the dissolution rate of the selected model drug. By using the method of experimental mixture design, solid dispersions were formulated by varying the ratio of carbamazepine (30-50 %), Gelucire® 44/14 (20-40 %) and Soluplus® polymer (30-50 %) (input parameters). Sixteen formulations were made and used for in vitro testing of the carbamazepine dissolution rate. The observed output parameters were the percentages of carbamazepine released after 10, 20, 30, 45, and 60 minutes. After the data analysis, three test formulations were chosen from different parts of the optimization area. They were prepared and the carbamazepine dissolution rate was determined, followed by stability assessment for 24 months under ambient conditions (25 °C, 40 % RH). The highest dissolution rate of carbamazepine from solid dispersions (more than 80 % in 30 minutes) was achieved at the carbamazepine mass fraction of about 40 %, Soluplus® of about 45 % and Gelucire® 44/14 of about 25 %. Comparing the predicted and the experimental obtained release rate profiles of carbamazepine from the three prepared optimized formulations, a significant compliance of the results was observed (f1<15; f2 >50). The application of the PAMPA (Parallel Artificial-Membrane Permeability Assay) test has shown that carbamazepine premeability was maintained and mildly increased in two out of the three tested optimzed solid state formulations. Raman spectroscopy, FT-IR and DSC analyes showed that in the three optimized solid dispersions, after preparation and 24 months of storage, interactions between carbamazepine and the excipients were not present and that carbamazepine remained in the single pharmacologically active crystal polymorph form III. Proper selection of solid dispersion proportions of carbamazepine, Gelucire® 44/14 and Soluplus® may significantly increase the dissolution rate of the active substance, and the method of experimental mixture design can be successfully used for optimization of these formulations.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability
T1  - Čvrste disperzije sa karbamazepinom: Optimizacija formulacija, karakterizacija i ispitivanje dugoročne stabilnosti
VL  - 72
IS  - 4
SP  - 191
EP  - 204
DO  - 10.2298/HEMIND171025013K
ER  - 

@article{
author = "Krstić, Marko and Lukić, I and Bušatlić, A and Lazarević, N and Vasiljević, Dragana",
year = "2018",
abstract = "Solid dispersions are defined as dispersions of one or more active pharmaceutical ingredients in inert solid-state carriers. They are made with the aim to increase solubility and the dissolution rate of low solubility active pharmaceutical ingredients, with the subsequent increase in their bioavailability. The aim of this study was the development and optimization of solid dispersion formulations with carbamazepine, using D-optimal experimental design, in order to increase the dissolution rate of the selected model drug. By using the method of experimental mixture design, solid dispersions were formulated by varying the ratio of carbamazepine (30-50 %), Gelucire® 44/14 (20-40 %) and Soluplus® polymer (30-50 %) (input parameters). Sixteen formulations were made and used for in vitro testing of the carbamazepine dissolution rate. The observed output parameters were the percentages of carbamazepine released after 10, 20, 30, 45, and 60 minutes. After the data analysis, three test formulations were chosen from different parts of the optimization area. They were prepared and the carbamazepine dissolution rate was determined, followed by stability assessment for 24 months under ambient conditions (25 °C, 40 % RH). The highest dissolution rate of carbamazepine from solid dispersions (more than 80 % in 30 minutes) was achieved at the carbamazepine mass fraction of about 40 %, Soluplus® of about 45 % and Gelucire® 44/14 of about 25 %. Comparing the predicted and the experimental obtained release rate profiles of carbamazepine from the three prepared optimized formulations, a significant compliance of the results was observed (f1<15; f2 >50). The application of the PAMPA (Parallel Artificial-Membrane Permeability Assay) test has shown that carbamazepine premeability was maintained and mildly increased in two out of the three tested optimzed solid state formulations. Raman spectroscopy, FT-IR and DSC analyes showed that in the three optimized solid dispersions, after preparation and 24 months of storage, interactions between carbamazepine and the excipients were not present and that carbamazepine remained in the single pharmacologically active crystal polymorph form III. Proper selection of solid dispersion proportions of carbamazepine, Gelucire® 44/14 and Soluplus® may significantly increase the dissolution rate of the active substance, and the method of experimental mixture design can be successfully used for optimization of these formulations.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability, Čvrste disperzije sa karbamazepinom: Optimizacija formulacija, karakterizacija i ispitivanje dugoročne stabilnosti",
volume = "72",
number = "4",
pages = "191-204",
doi = "10.2298/HEMIND171025013K"
}

Krstić, M., Lukić, I., Bušatlić, A., Lazarević, N.,& Vasiljević, D.. (2018). Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 72(4), 191-204.
https://doi.org/10.2298/HEMIND171025013K

Krstić M, Lukić I, Bušatlić A, Lazarević N, Vasiljević D. Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability. in Hemijska industrija. 2018;72(4):191-204.
doi:10.2298/HEMIND171025013K .

Krstić, Marko, Lukić, I, Bušatlić, A, Lazarević, N, Vasiljević, Dragana, "Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability" in Hemijska industrija, 72, no. 4 (2018):191-204,
https://doi.org/10.2298/HEMIND171025013K . .

TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Bojović, Lidija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3107
AB  - There is a growing demand for organic and natural cosmetic products, especially in the EU countries and the rest of the world, as the consumer awareness for the preservation of the environment and natural resources has increased, but above all with the belief that these products are safe. All cosmetic products, even organic and natural, that are placed on the market of EU countries must comply with the Cosmetics Regulation 1223/2009 EC requirements in terms of quality, safety and efficacy. However, there is no harmonized European regulation today, that sets out the criteria for natural and organic cosmetic products. The most important standards for natural and organic cosmetics in the EU countries are COSMOS and NATRUE standard. According to the requirements of these standards, selected raw materials, mainly of plant origin, which are processed by approved procedures, are allowed for organic and natural cosmetic products manufacturing. Numerous studies indicate that toxicological properties of natural substances deserve much more attention, in order to determine their safety. The safety, efficacy and quality of cosmetic products are prerequisites. That is why it is necessary to create a regulatory framework for natural and organic cosmetic products, which will not mislead the consumers and which will be more binding for manufacturers. Also, it is necessary to create a precise guideline for the safety assessment of organic and natural cosmetic products.
AB  - Povećana potražnja organskih i prirodnih kozmetičkih proizvoda, u zemljama EU i u svetu, posledica je porasta svesti potrošača za očuvanjem životne sredine i prirodnih resursa, ali pre svega verovanjem da su ti proizvodi bezbedni. Svi kozmetički proizvodi, pa i organski i prirodni, koji se plasiraju na tržište zemalja EU moraju biti u skladu sa zahtevima Uredbe 1223/2009 EC o kozmetičkim proizvodima, u pogledu kvaliteta, efikasnosti i bezbednosti. Danas ne postoji usklađeni evropski zakonski propis, koji određuje kriterijume za prirodne i organske kozmetičke proizvode. Najznačajniji dobrovoljni standardi za prirodne i organske kozmetičke proizvode u zemljama EU su COSMOS i NATRUE standard. Prema zahtevima ovih standarda, organski i prirodni kozmetički proizvodi se izrađuju od odabranih sastojaka/sirovina, uglavnom biljnog porekla, koje su obrađene dozvoljenim postupcima. Brojna istraživanja ukazuju da prirodne sirovine zaslužuju mnogo više pažnje u toksikološkom smislu, da bi se utvrdilo da li su bezbedne. Bezbednost, efikasnost i kvalitet kozmetičkih proizvoda su na prvom mestu. Upravo zato je neophodno usvajanje zakonskih propisa za prirodne i organske kozmetičke proizvode, koji neće dati prostora za obmanjivanje potrošača i koji će biti obavezujući za proizvođače. Takođe, potrebno je usvajanje preciznih smernica za procenu bezbednosti organskih i prirodnih kozmetičkih proizvoda.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Organic and natural cosmetic products : How safe are they?
T1  - Organski i prirodni kozmetički proizvodi - koliko su zaista bezbedni?
VL  - 68
IS  - 5
SP  - 990
EP  - 1007
DO  - 10.5937/ArhFarm1805990V
ER  - 

@article{
author = "Vasiljević, Dragana and Bojović, Lidija",
year = "2018",
abstract = "There is a growing demand for organic and natural cosmetic products, especially in the EU countries and the rest of the world, as the consumer awareness for the preservation of the environment and natural resources has increased, but above all with the belief that these products are safe. All cosmetic products, even organic and natural, that are placed on the market of EU countries must comply with the Cosmetics Regulation 1223/2009 EC requirements in terms of quality, safety and efficacy. However, there is no harmonized European regulation today, that sets out the criteria for natural and organic cosmetic products. The most important standards for natural and organic cosmetics in the EU countries are COSMOS and NATRUE standard. According to the requirements of these standards, selected raw materials, mainly of plant origin, which are processed by approved procedures, are allowed for organic and natural cosmetic products manufacturing. Numerous studies indicate that toxicological properties of natural substances deserve much more attention, in order to determine their safety. The safety, efficacy and quality of cosmetic products are prerequisites. That is why it is necessary to create a regulatory framework for natural and organic cosmetic products, which will not mislead the consumers and which will be more binding for manufacturers. Also, it is necessary to create a precise guideline for the safety assessment of organic and natural cosmetic products., Povećana potražnja organskih i prirodnih kozmetičkih proizvoda, u zemljama EU i u svetu, posledica je porasta svesti potrošača za očuvanjem životne sredine i prirodnih resursa, ali pre svega verovanjem da su ti proizvodi bezbedni. Svi kozmetički proizvodi, pa i organski i prirodni, koji se plasiraju na tržište zemalja EU moraju biti u skladu sa zahtevima Uredbe 1223/2009 EC o kozmetičkim proizvodima, u pogledu kvaliteta, efikasnosti i bezbednosti. Danas ne postoji usklađeni evropski zakonski propis, koji određuje kriterijume za prirodne i organske kozmetičke proizvode. Najznačajniji dobrovoljni standardi za prirodne i organske kozmetičke proizvode u zemljama EU su COSMOS i NATRUE standard. Prema zahtevima ovih standarda, organski i prirodni kozmetički proizvodi se izrađuju od odabranih sastojaka/sirovina, uglavnom biljnog porekla, koje su obrađene dozvoljenim postupcima. Brojna istraživanja ukazuju da prirodne sirovine zaslužuju mnogo više pažnje u toksikološkom smislu, da bi se utvrdilo da li su bezbedne. Bezbednost, efikasnost i kvalitet kozmetičkih proizvoda su na prvom mestu. Upravo zato je neophodno usvajanje zakonskih propisa za prirodne i organske kozmetičke proizvode, koji neće dati prostora za obmanjivanje potrošača i koji će biti obavezujući za proizvođače. Takođe, potrebno je usvajanje preciznih smernica za procenu bezbednosti organskih i prirodnih kozmetičkih proizvoda.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Organic and natural cosmetic products : How safe are they?, Organski i prirodni kozmetički proizvodi - koliko su zaista bezbedni?",
volume = "68",
number = "5",
pages = "990-1007",
doi = "10.5937/ArhFarm1805990V"
}

Vasiljević, D.,& Bojović, L.. (2018). Organic and natural cosmetic products : How safe are they?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(5), 990-1007.
https://doi.org/10.5937/ArhFarm1805990V

Vasiljević D, Bojović L. Organic and natural cosmetic products : How safe are they?. in Arhiv za farmaciju. 2018;68(5):990-1007.
doi:10.5937/ArhFarm1805990V .

Vasiljević, Dragana, Bojović, Lidija, "Organic and natural cosmetic products : How safe are they?" in Arhiv za farmaciju, 68, no. 5 (2018):990-1007,
https://doi.org/10.5937/ArhFarm1805990V . .

TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Đuriš, Jelena
AU  - Jakimenko, Sergej
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2862
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3445
AB  - In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Dispersion Science and Technology
T1  - Application of the fractional factorial design in multiple W/O/W emulsions
VL  - 38
IS  - 12
SP  - 1732
EP  - 1737
DO  - 10.1080/01932691.2016.1278551
ER  - 

@article{
author = "Vasiljević, Dragana and Đuriš, Jelena and Jakimenko, Sergej and Ibrić, Svetlana",
year = "2017",
abstract = "In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Dispersion Science and Technology",
title = "Application of the fractional factorial design in multiple W/O/W emulsions",
volume = "38",
number = "12",
pages = "1732-1737",
doi = "10.1080/01932691.2016.1278551"
}

Vasiljević, D., Đuriš, J., Jakimenko, S.,& Ibrić, S.. (2017). Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology
Taylor & Francis Inc, Philadelphia., 38(12), 1732-1737.
https://doi.org/10.1080/01932691.2016.1278551

Vasiljević D, Đuriš J, Jakimenko S, Ibrić S. Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology. 2017;38(12):1732-1737.
doi:10.1080/01932691.2016.1278551 .

Vasiljević, Dragana, Đuriš, Jelena, Jakimenko, Sergej, Ibrić, Svetlana, "Application of the fractional factorial design in multiple W/O/W emulsions" in Journal of Dispersion Science and Technology, 38, no. 12 (2017):1732-1737,
https://doi.org/10.1080/01932691.2016.1278551 . .

TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Đuriš, Jelena
AU  - Jakimenko, Sergej
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2862
AB  - In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Dispersion Science and Technology
T1  - Application of the fractional factorial design in multiple W/O/W emulsions
VL  - 38
IS  - 12
SP  - 1732
EP  - 1737
DO  - 10.1080/01932691.2016.1278551
ER  - 

@article{
author = "Vasiljević, Dragana and Đuriš, Jelena and Jakimenko, Sergej and Ibrić, Svetlana",
year = "2017",
abstract = "In presented research, multiple W/O/W emulsions were developed by using experimental design method. A 24-1 fractional factorial design was performed by varying the following input parameters: primary polymeric emulsifier (PEG 30-dipolyhydroxystearate) concentration (0.8% and 2.4%), secondary polymeric emulsifier (Poloxamer 407) concentration (0.8% and 1.2%), electrolyte magnesium sulfate heptahydrate (0.08% and 0.4%) and electrolyte sodium chloride (0.08% and 0.4%). Multiple emulsions were prepared by a two-step emulsification process. Obtained emulsions were characterized with rheological measurements, conductivity and centrifugation tests. Factorial analysis revealed that the concentration of the primary emulsifier was the predominant factor influencing the phase separation, conductivity and maximal apparent viscosity. Additionally, electrolyte magnesium sulfate heptahydrate was more efficient in stabilizing these systems, compared to sodium chloride. The applied fractional factorial design method enabled determination of the optimal concentrations of the primary and secondary emulsifier, as well as the concentration of electrolytes, in order to obtain W/O/W emulsions with desired maximal apparent viscosities, low values of conductivity and without phase separation after centrifugation. [GRAPHICS] .",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Dispersion Science and Technology",
title = "Application of the fractional factorial design in multiple W/O/W emulsions",
volume = "38",
number = "12",
pages = "1732-1737",
doi = "10.1080/01932691.2016.1278551"
}

Vasiljević, D., Đuriš, J., Jakimenko, S.,& Ibrić, S.. (2017). Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology
Taylor & Francis Inc, Philadelphia., 38(12), 1732-1737.
https://doi.org/10.1080/01932691.2016.1278551

Vasiljević D, Đuriš J, Jakimenko S, Ibrić S. Application of the fractional factorial design in multiple W/O/W emulsions. in Journal of Dispersion Science and Technology. 2017;38(12):1732-1737.
doi:10.1080/01932691.2016.1278551 .

Vasiljević, Dragana, Đuriš, Jelena, Jakimenko, Sergej, Ibrić, Svetlana, "Application of the fractional factorial design in multiple W/O/W emulsions" in Journal of Dispersion Science and Technology, 38, no. 12 (2017):1732-1737,
https://doi.org/10.1080/01932691.2016.1278551 . .

TY  - JOUR
AU  - Vasiljević, Dragana
AU  - Radonjić, Nataša
AU  - Vuleta, Gordana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2980
AB  - Vitamins A, E, C, B3 and provitamin B5 (panthenol), and their numerous derivatives are most widely used in cosmetic products. Cosmetic retinoids (retinol, retinaldehyde, and retinyl esters) have been used for years in cosmetic treatments of (photo)aged skin - brightened hyperpigmentation, reducing roughness of the skin and fine lines and wrinkles. Using the new vitamin A derivative, retinyl retinoate, is considered to overcome the problems associated with instability and undesirable effects of retinol. Hydroxypinacolone retinoate is a new anti-aging ingredient with the efficacy of retinol, but with significantly less irritant potential. Vitamin E (tocopherol) slows down the formation of wrinkles and alleviates the existing ones. Because of the pronounced instability, vitamin E is used in the form of esters, usually as tocopheryl acetate. The novelty on the market is a water-soluble derivative of vitamin E - sodium tocopheryl phosphate. Vitamin C also has positive effects on the skin. However, free vitamin C (ascorbic acid) is very unstable and easily loses its activity. Newer derivatives of vitamin C, which may be water-soluble, amphiphilic or liposoluble, have improved stability compared to the ascorbic acid. They are used in skin care and skin lightening products. Panthenol, which is a very good moisturizer, has been used in various cosmetic products for skin and hair for many years. Vitamin B3 (niacinamide) is commonly used in facial day creams, as skin conditioner. Vitamins in cosmetic products can be considered as safe cosmetic active ingredients, when used in appropriate chemical forms and in allowed concentrations.
AB  - U savremenim kozmetičkim proizvodima najviše se koriste vitamini A, E, C, B3 i provitamin B5 (pantenol), kao i njihovi brojni derivati. Kozmetički retinoidi (retinol, retinaldehid i retinil estri) se godinama koriste u kozmetičkom tretmanu znakova (foto)ostarele kože jer posvetljuju hiperpigmentacije, smanjuju grubost kože i fine linije i bore. Noviji derivati vitamina A, retinil retinoat i hidroksipinakolon retinoat su anti-age sastojci povećane stabilnosti i smanjenog iritacionog potencijala, u poređenju sa retinolom. Vitamin E (tokoferol), dovodi do usporavanja nastanka i prividnog smanjenja postojećih bora. Zbog izražene nestabilnosti, vitamin E se koristi u obliku estara, najčešće kao tokoferil acetat. Novina na tržištu je hidrosolubilni derivat vitamina E - natrijum tokoferil fosfat. Vitamin C (askorbinska kiselina) takođe ima pozitivne efekte na koži, ali je veoma nestabilan. Noviji derivati vitamina C, koji mogu biti hidrosolubilni, amfifilni ili liposolubilni su poboljšane stabilnosti u odnosu na askorbinsku kiselinu. Koriste se u proizvodima za negu i posvetljivanje kože. Pantenol je izuzetno dobar ovlaživač kože i kose. Vitamin B3 (niacinamid) se uobičajeno koristi u dnevnim kremovima za negu lica, kao kondicioner kože. Vitamini u kozmetičkim proizvodima se mogu smatrati bezbednim KAS, kada se koriste u odgovarajućim hemijskim oblicima i u odobrenim koncentracijama.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Vitamins in cosmetic products: Current opinions and practice
T1  - Vitamini u kozmetičkim proizvodima - savremeni stavovi i praksa
VL  - 67
IS  - 4
SP  - 248
EP  - 264
DO  - 10.5937/arhfarm1704248V
ER  - 

@article{
author = "Vasiljević, Dragana and Radonjić, Nataša and Vuleta, Gordana",
year = "2017",
abstract = "Vitamins A, E, C, B3 and provitamin B5 (panthenol), and their numerous derivatives are most widely used in cosmetic products. Cosmetic retinoids (retinol, retinaldehyde, and retinyl esters) have been used for years in cosmetic treatments of (photo)aged skin - brightened hyperpigmentation, reducing roughness of the skin and fine lines and wrinkles. Using the new vitamin A derivative, retinyl retinoate, is considered to overcome the problems associated with instability and undesirable effects of retinol. Hydroxypinacolone retinoate is a new anti-aging ingredient with the efficacy of retinol, but with significantly less irritant potential. Vitamin E (tocopherol) slows down the formation of wrinkles and alleviates the existing ones. Because of the pronounced instability, vitamin E is used in the form of esters, usually as tocopheryl acetate. The novelty on the market is a water-soluble derivative of vitamin E - sodium tocopheryl phosphate. Vitamin C also has positive effects on the skin. However, free vitamin C (ascorbic acid) is very unstable and easily loses its activity. Newer derivatives of vitamin C, which may be water-soluble, amphiphilic or liposoluble, have improved stability compared to the ascorbic acid. They are used in skin care and skin lightening products. Panthenol, which is a very good moisturizer, has been used in various cosmetic products for skin and hair for many years. Vitamin B3 (niacinamide) is commonly used in facial day creams, as skin conditioner. Vitamins in cosmetic products can be considered as safe cosmetic active ingredients, when used in appropriate chemical forms and in allowed concentrations., U savremenim kozmetičkim proizvodima najviše se koriste vitamini A, E, C, B3 i provitamin B5 (pantenol), kao i njihovi brojni derivati. Kozmetički retinoidi (retinol, retinaldehid i retinil estri) se godinama koriste u kozmetičkom tretmanu znakova (foto)ostarele kože jer posvetljuju hiperpigmentacije, smanjuju grubost kože i fine linije i bore. Noviji derivati vitamina A, retinil retinoat i hidroksipinakolon retinoat su anti-age sastojci povećane stabilnosti i smanjenog iritacionog potencijala, u poređenju sa retinolom. Vitamin E (tokoferol), dovodi do usporavanja nastanka i prividnog smanjenja postojećih bora. Zbog izražene nestabilnosti, vitamin E se koristi u obliku estara, najčešće kao tokoferil acetat. Novina na tržištu je hidrosolubilni derivat vitamina E - natrijum tokoferil fosfat. Vitamin C (askorbinska kiselina) takođe ima pozitivne efekte na koži, ali je veoma nestabilan. Noviji derivati vitamina C, koji mogu biti hidrosolubilni, amfifilni ili liposolubilni su poboljšane stabilnosti u odnosu na askorbinsku kiselinu. Koriste se u proizvodima za negu i posvetljivanje kože. Pantenol je izuzetno dobar ovlaživač kože i kose. Vitamin B3 (niacinamid) se uobičajeno koristi u dnevnim kremovima za negu lica, kao kondicioner kože. Vitamini u kozmetičkim proizvodima se mogu smatrati bezbednim KAS, kada se koriste u odgovarajućim hemijskim oblicima i u odobrenim koncentracijama.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Vitamins in cosmetic products: Current opinions and practice, Vitamini u kozmetičkim proizvodima - savremeni stavovi i praksa",
volume = "67",
number = "4",
pages = "248-264",
doi = "10.5937/arhfarm1704248V"
}

Vasiljević, D., Radonjić, N.,& Vuleta, G.. (2017). Vitamins in cosmetic products: Current opinions and practice. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(4), 248-264.
https://doi.org/10.5937/arhfarm1704248V

Vasiljević D, Radonjić N, Vuleta G. Vitamins in cosmetic products: Current opinions and practice. in Arhiv za farmaciju. 2017;67(4):248-264.
doi:10.5937/arhfarm1704248V .

Vasiljević, Dragana, Radonjić, Nataša, Vuleta, Gordana, "Vitamins in cosmetic products: Current opinions and practice" in Arhiv za farmaciju, 67, no. 4 (2017):248-264,
https://doi.org/10.5937/arhfarm1704248V . .

TY  - JOUR
AU  - Crevar-Sakač, Milkica
AU  - Vujić, Zorica
AU  - Vujčić, Zoran
AU  - Marković, Bojan
AU  - Vasiljević, Dragana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2623
AB  - A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed for the quantification of atorvastatin, ortho-hydroxyatorvastatin, para-hydroxyatorvastatin, and atorvastatin lactone in rat plasma. Solid-phase extraction was used for preparation of samples. Rosuvastatin was chosen as an internal standard. Chromatographic separation was achieved on ZORBAX Eclipse C-18 Analytical, 4.6 x 100 mm (3.5 mu m) column with a gradient mobile phase composed of acetonitrile and 0.1% acetic acid, at a flow rate of 400 mu L min(-1). The column was kept at constant temperature (25 degrees C), and autosampler tray temperature was set at 4 degrees C. The following selected reaction monitoring (SRM) transitions were selected: (m/z, Q1 -> Q3, collision energy) atorvastatin (559.47 -> 440.03, 22 eV), atorvastatin lactone (541.36 -> 448.02, 19 eV), orthohydroxyatorvastatin (575.20 -> 440.18, 20 eV), para-hydroxyatorvastatin (575.54 -> 440.18, 20 eV), and rosuvastatin (482.25 with selected combination of two fragments 257.77, 31 eV, and 299.81, 35 eV) in positive ion mode. The method was validated over a concentration range of 0.5-20 ng mL(-1) for ortho-hydroxyatorvastatin and para-hydroxyatorvastatin and 0.1-20 ng mL(-1) for atorvastatin and atorvastatin lactone with excellent linearity (r(2) >= 0.99). This method demonstrated acceptable precision and accuracy at four quality control concentration levels. The detection limits were 0.1 and 0.13 ng mL(-1) for orthohydroxyatorvastatin and para-hydroxyatorvastatin, respectively, and 0.05 ng mL(-1) for atorvastatin and atorvastatin lactone. All analytes were found to be stable at examined conditions. Validated method was applied for determination of atorvastatin and its metabolites in plasma of experimental animals.
PB  - Akademiai Kiado Rt, Budapest
T2  - Acta Chromatographica
T1  - LC-MS/MS Method for Quantification of Atorvastatin, o-Hydroxyatorvastatin, p-Hydroxyatorvastatin, and Atorvastatin Lactone in Rat Plasma
VL  - 28
IS  - 3
SP  - 281
EP  - 298
DO  - 10.1556/1326.2016.28.3.1
ER  - 

@article{
author = "Crevar-Sakač, Milkica and Vujić, Zorica and Vujčić, Zoran and Marković, Bojan and Vasiljević, Dragana",
year = "2016",
abstract = "A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed for the quantification of atorvastatin, ortho-hydroxyatorvastatin, para-hydroxyatorvastatin, and atorvastatin lactone in rat plasma. Solid-phase extraction was used for preparation of samples. Rosuvastatin was chosen as an internal standard. Chromatographic separation was achieved on ZORBAX Eclipse C-18 Analytical, 4.6 x 100 mm (3.5 mu m) column with a gradient mobile phase composed of acetonitrile and 0.1% acetic acid, at a flow rate of 400 mu L min(-1). The column was kept at constant temperature (25 degrees C), and autosampler tray temperature was set at 4 degrees C. The following selected reaction monitoring (SRM) transitions were selected: (m/z, Q1 -> Q3, collision energy) atorvastatin (559.47 -> 440.03, 22 eV), atorvastatin lactone (541.36 -> 448.02, 19 eV), orthohydroxyatorvastatin (575.20 -> 440.18, 20 eV), para-hydroxyatorvastatin (575.54 -> 440.18, 20 eV), and rosuvastatin (482.25 with selected combination of two fragments 257.77, 31 eV, and 299.81, 35 eV) in positive ion mode. The method was validated over a concentration range of 0.5-20 ng mL(-1) for ortho-hydroxyatorvastatin and para-hydroxyatorvastatin and 0.1-20 ng mL(-1) for atorvastatin and atorvastatin lactone with excellent linearity (r(2) >= 0.99). This method demonstrated acceptable precision and accuracy at four quality control concentration levels. The detection limits were 0.1 and 0.13 ng mL(-1) for orthohydroxyatorvastatin and para-hydroxyatorvastatin, respectively, and 0.05 ng mL(-1) for atorvastatin and atorvastatin lactone. All analytes were found to be stable at examined conditions. Validated method was applied for determination of atorvastatin and its metabolites in plasma of experimental animals.",
publisher = "Akademiai Kiado Rt, Budapest",
journal = "Acta Chromatographica",
title = "LC-MS/MS Method for Quantification of Atorvastatin, o-Hydroxyatorvastatin, p-Hydroxyatorvastatin, and Atorvastatin Lactone in Rat Plasma",
volume = "28",
number = "3",
pages = "281-298",
doi = "10.1556/1326.2016.28.3.1"
}

Crevar-Sakač, M., Vujić, Z., Vujčić, Z., Marković, B.,& Vasiljević, D.. (2016). LC-MS/MS Method for Quantification of Atorvastatin, o-Hydroxyatorvastatin, p-Hydroxyatorvastatin, and Atorvastatin Lactone in Rat Plasma. in Acta Chromatographica
Akademiai Kiado Rt, Budapest., 28(3), 281-298.
https://doi.org/10.1556/1326.2016.28.3.1

Crevar-Sakač M, Vujić Z, Vujčić Z, Marković B, Vasiljević D. LC-MS/MS Method for Quantification of Atorvastatin, o-Hydroxyatorvastatin, p-Hydroxyatorvastatin, and Atorvastatin Lactone in Rat Plasma. in Acta Chromatographica. 2016;28(3):281-298.
doi:10.1556/1326.2016.28.3.1 .

Crevar-Sakač, Milkica, Vujić, Zorica, Vujčić, Zoran, Marković, Bojan, Vasiljević, Dragana, "LC-MS/MS Method for Quantification of Atorvastatin, o-Hydroxyatorvastatin, p-Hydroxyatorvastatin, and Atorvastatin Lactone in Rat Plasma" in Acta Chromatographica, 28, no. 3 (2016):281-298,
https://doi.org/10.1556/1326.2016.28.3.1 . .

TY  - JOUR
AU  - Krstić, Marko
AU  - Ražić, Slavica
AU  - Đekić, Ljiljana
AU  - Dobričić, Vladimir
AU  - Momcilović, Milica A.
AU  - Vasiljević, Dragana
AU  - Ibrić, Svetlana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2433
AB  - The purpose of this study was to investigate the solid self-emulsifying drug delivery system (SSEDDS), as a potential delivery system for poorly water soluble carbamazepine by application of mixture design. The self-emulsifying drug delivery system (SEDDS) was formulated using Polysorbate 80, Transcutol (R) HP and Mygliol (R) 812. The input parameters for mixture design (components of SSEDDS) were: appropriate SEDDS, carbamazepine and adsorbent, Neusilin (R) UFL2, with appropriate ranges 10-30%, 30-50% and 40-60%, respectively. The output parameters were the percentages of carbamazepine released after 10 and 30 min. The aim was to formulate SSEDDS with very fast drug release, i.e. more than 80% of carbamazepine has to be released in 30 min. Optimal formulations were examined through the dissolution test, parallel artificial membrane permeability assay (PAMPA), differential scanning calorimetry and thermal gravimetric analysis. With the obtained mixture design models, for any combination of factors ratios, it is possible to predict the profile of carbamazepine release. Optimal formulations exhibited significantly improved drug release and permeability.
PB  - Colegio Farmaceuticos Provincia De Buenos Aires, La Plata
T2  - Latin American Journal of Pharmacy
T1  - Application of a Mixture Experimental Design in the Optimization of the Formulation of Solid Self-Emulsifying Drug Delivery Systems Containing Carbamazepine
VL  - 34
IS  - 5
SP  - 885
EP  - 894
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2433
ER  - 

@article{
author = "Krstić, Marko and Ražić, Slavica and Đekić, Ljiljana and Dobričić, Vladimir and Momcilović, Milica A. and Vasiljević, Dragana and Ibrić, Svetlana",
year = "2015",
abstract = "The purpose of this study was to investigate the solid self-emulsifying drug delivery system (SSEDDS), as a potential delivery system for poorly water soluble carbamazepine by application of mixture design. The self-emulsifying drug delivery system (SEDDS) was formulated using Polysorbate 80, Transcutol (R) HP and Mygliol (R) 812. The input parameters for mixture design (components of SSEDDS) were: appropriate SEDDS, carbamazepine and adsorbent, Neusilin (R) UFL2, with appropriate ranges 10-30%, 30-50% and 40-60%, respectively. The output parameters were the percentages of carbamazepine released after 10 and 30 min. The aim was to formulate SSEDDS with very fast drug release, i.e. more than 80% of carbamazepine has to be released in 30 min. Optimal formulations were examined through the dissolution test, parallel artificial membrane permeability assay (PAMPA), differential scanning calorimetry and thermal gravimetric analysis. With the obtained mixture design models, for any combination of factors ratios, it is possible to predict the profile of carbamazepine release. Optimal formulations exhibited significantly improved drug release and permeability.",
publisher = "Colegio Farmaceuticos Provincia De Buenos Aires, La Plata",
journal = "Latin American Journal of Pharmacy",
title = "Application of a Mixture Experimental Design in the Optimization of the Formulation of Solid Self-Emulsifying Drug Delivery Systems Containing Carbamazepine",
volume = "34",
number = "5",
pages = "885-894",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2433"
}

Krstić, M., Ražić, S., Đekić, L., Dobričić, V., Momcilović, M. A., Vasiljević, D.,& Ibrić, S.. (2015). Application of a Mixture Experimental Design in the Optimization of the Formulation of Solid Self-Emulsifying Drug Delivery Systems Containing Carbamazepine. in Latin American Journal of Pharmacy
Colegio Farmaceuticos Provincia De Buenos Aires, La Plata., 34(5), 885-894.
https://hdl.handle.net/21.15107/rcub_farfar_2433

Krstić M, Ražić S, Đekić L, Dobričić V, Momcilović MA, Vasiljević D, Ibrić S. Application of a Mixture Experimental Design in the Optimization of the Formulation of Solid Self-Emulsifying Drug Delivery Systems Containing Carbamazepine. in Latin American Journal of Pharmacy. 2015;34(5):885-894.
https://hdl.handle.net/21.15107/rcub_farfar_2433 .

Krstić, Marko, Ražić, Slavica, Đekić, Ljiljana, Dobričić, Vladimir, Momcilović, Milica A., Vasiljević, Dragana, Ibrić, Svetlana, "Application of a Mixture Experimental Design in the Optimization of the Formulation of Solid Self-Emulsifying Drug Delivery Systems Containing Carbamazepine" in Latin American Journal of Pharmacy, 34, no. 5 (2015):885-894,
https://hdl.handle.net/21.15107/rcub_farfar_2433 .

TY  - JOUR
AU  - Nikolić, Nenad D.
AU  - Medarević, Đorđe
AU  - Đuriš, Jelena
AU  - Vasiljević, Dragana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2352
AB  - This study investigates the use of high molecular weight hydrophilic polymers, hypromellose and hydroxypropylcellulose, for the preparation of sustained release matrix tablets containing a high-dose highly soluble drug, tramadol HCl. The proportion of polymer, type of insoluble filler, proportion of tramadol HCl, amount of drug in the tablet and compression pressure were recognized as critical formulation and process parameters and their influence on drug release and tablet mechanical properties was evaluated. Tensile strength was used as an indicator of the mechanical properties of the tablets. Experiments were performed with utilization of a compaction simulator, a device that simulates compaction profiles of large scale rotary tablet presses. In formulations with both polymers, the proportion of tramadol HCl was the most critical formulation parameter, wherein increasing the proportion of tramadol HCl increased its release rate in the early stages of drug release. Regarding the tablet mechanical characteristics, the filler type had the most pronounced effect in formulations with both polymers. Higher tensile strengths were obtained with Avicel PH 102 as the filler in formulations with both HPMC and HPC.
AB  - U ovom radu ispitivana je mogućnost primene hipromeloze i hidroksipropilceluloze, kao hidrofilnih polimera velike molekulske mase, za izradu matriks tableta sa produženim oslobađanjem, sa visoko rastvorljivom, visoko doziranom lekovitom supstancom tramadol-hidrohloridom. Udeo hidrofilnog polimera, vrsta nerastvorljivog sredstva za dopunjavanje, udeo tramadol-hidrohlorida, količina lekovite supstance u pojedinačnoj tableti i pritisak kompresije su prepoznati kao kritični parametri formulacije i procesa i u radu je ispitivan njihov uticaj na oslobađanje lekovite supstance i mehaničke karakteristike izrađenih tableta. Zatezna čvrstina tableta je korišćena kao indikator mehaničkih karakteristika tableta. Svi eksperimenti su vršeni korišćenjem simulatora kompakcije, koji omogućava simuliranje profila kompakcije rotacionih tablet mašina velikog kapaciteta. Kod formulacija izrađenih sa obe vrste polimera, udeo tramadol-hidrohlorida se pokazao kao najkritičniji faktor formulacije, pri čemu je povećanje udela tramadol-hidrohlorida dovelo do povećanja brzine oslobađanja ove lekovite supstance u početnim fazama oslobađanja lekovite supstance. Vrsta sredstva za dopunjavanje je pokazala najveći uticaj na mehaničke karakteristike izrađenih tableta, kod formulacija izrađenih sa oba tipa hidrofilnih polimera. Više vrednosti zatezne čvrstine tableta su postignute kod formulacija izrađenih korišćenjem Avicel PH 102 kao sredstva za dopunjavanje, bez obzira da li je u sastav tableta kao matriks polimer ulazila hipromeloza ili hidroksipropilceluloza.
PB  - Savez hemijskih inženjera, Beograd
T2  - CICEQ - Chemical Industry and Chemical Engineering Quarterly
T1  - Comparison of drug release and mechanical properties of tramadol hydrochloride matrix tablets prepared with selected hydrophilic polymers
T1  - Poređenje oslobađanja tramadol-hidrohlorida i mehaničkih karakteristika matriks tableta izrađenih sa odabranim hidrofilnim polimerima
VL  - 21
IS  - 3
SP  - 369
EP  - 378
DO  - 10.2298/CICEQ140613040N
ER  - 

@article{
author = "Nikolić, Nenad D. and Medarević, Đorđe and Đuriš, Jelena and Vasiljević, Dragana",
year = "2015",
abstract = "This study investigates the use of high molecular weight hydrophilic polymers, hypromellose and hydroxypropylcellulose, for the preparation of sustained release matrix tablets containing a high-dose highly soluble drug, tramadol HCl. The proportion of polymer, type of insoluble filler, proportion of tramadol HCl, amount of drug in the tablet and compression pressure were recognized as critical formulation and process parameters and their influence on drug release and tablet mechanical properties was evaluated. Tensile strength was used as an indicator of the mechanical properties of the tablets. Experiments were performed with utilization of a compaction simulator, a device that simulates compaction profiles of large scale rotary tablet presses. In formulations with both polymers, the proportion of tramadol HCl was the most critical formulation parameter, wherein increasing the proportion of tramadol HCl increased its release rate in the early stages of drug release. Regarding the tablet mechanical characteristics, the filler type had the most pronounced effect in formulations with both polymers. Higher tensile strengths were obtained with Avicel PH 102 as the filler in formulations with both HPMC and HPC., U ovom radu ispitivana je mogućnost primene hipromeloze i hidroksipropilceluloze, kao hidrofilnih polimera velike molekulske mase, za izradu matriks tableta sa produženim oslobađanjem, sa visoko rastvorljivom, visoko doziranom lekovitom supstancom tramadol-hidrohloridom. Udeo hidrofilnog polimera, vrsta nerastvorljivog sredstva za dopunjavanje, udeo tramadol-hidrohlorida, količina lekovite supstance u pojedinačnoj tableti i pritisak kompresije su prepoznati kao kritični parametri formulacije i procesa i u radu je ispitivan njihov uticaj na oslobađanje lekovite supstance i mehaničke karakteristike izrađenih tableta. Zatezna čvrstina tableta je korišćena kao indikator mehaničkih karakteristika tableta. Svi eksperimenti su vršeni korišćenjem simulatora kompakcije, koji omogućava simuliranje profila kompakcije rotacionih tablet mašina velikog kapaciteta. Kod formulacija izrađenih sa obe vrste polimera, udeo tramadol-hidrohlorida se pokazao kao najkritičniji faktor formulacije, pri čemu je povećanje udela tramadol-hidrohlorida dovelo do povećanja brzine oslobađanja ove lekovite supstance u početnim fazama oslobađanja lekovite supstance. Vrsta sredstva za dopunjavanje je pokazala najveći uticaj na mehaničke karakteristike izrađenih tableta, kod formulacija izrađenih sa oba tipa hidrofilnih polimera. Više vrednosti zatezne čvrstine tableta su postignute kod formulacija izrađenih korišćenjem Avicel PH 102 kao sredstva za dopunjavanje, bez obzira da li je u sastav tableta kao matriks polimer ulazila hipromeloza ili hidroksipropilceluloza.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "CICEQ - Chemical Industry and Chemical Engineering Quarterly",
title = "Comparison of drug release and mechanical properties of tramadol hydrochloride matrix tablets prepared with selected hydrophilic polymers, Poređenje oslobađanja tramadol-hidrohlorida i mehaničkih karakteristika matriks tableta izrađenih sa odabranim hidrofilnim polimerima",
volume = "21",
number = "3",
pages = "369-378",
doi = "10.2298/CICEQ140613040N"
}

Nikolić, N. D., Medarević, Đ., Đuriš, J.,& Vasiljević, D.. (2015). Comparison of drug release and mechanical properties of tramadol hydrochloride matrix tablets prepared with selected hydrophilic polymers. in CICEQ - Chemical Industry and Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 21(3), 369-378.
https://doi.org/10.2298/CICEQ140613040N

Nikolić ND, Medarević Đ, Đuriš J, Vasiljević D. Comparison of drug release and mechanical properties of tramadol hydrochloride matrix tablets prepared with selected hydrophilic polymers. in CICEQ - Chemical Industry and Chemical Engineering Quarterly. 2015;21(3):369-378.
doi:10.2298/CICEQ140613040N .

Nikolić, Nenad D., Medarević, Đorđe, Đuriš, Jelena, Vasiljević, Dragana, "Comparison of drug release and mechanical properties of tramadol hydrochloride matrix tablets prepared with selected hydrophilic polymers" in CICEQ - Chemical Industry and Chemical Engineering Quarterly, 21, no. 3 (2015):369-378,
https://doi.org/10.2298/CICEQ140613040N . .

TY  - JOUR
AU  - Emeti, Ana
AU  - Vasiljević, Dragana
AU  - Primorac, Marija
AU  - Vuleta, Gordana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2500
AB  - Sea water, salt and mud have been used for centuries in beautification treatments, but their active ingredients have become a recent challenge in formulating new cosmetic products. Cosmetic ingredients which originate from the sea, are mostly obtained from algae, microalgae, marine sponges, corals and microorganisms. Exopolysaccharides (EPS) are new cosmetic ingredients produced by marine micro-organisms. They are used to protect skin from harmful external influences, give it softness and minimize fine lines. Pseudopterosins, present in the extracts of corals, are used to soothe the skin, while marine sponges are one of the major alternative to animal-derived collagen. Algae have been the most researched group, with the greatest potential among different sources of marine ingredients. Carrageenan, agar, and alginates from algae act as humectants, thickeners and gelling agents. The active ingredients of algae extracts (polysaccharides, proteins, vitamins, minerals) could hydrate, minimize fine lines, protect the skin from UV radiation, decrease redness and cellulite.
AB  - Morska voda, so i mulj koriste se od davnina u tretmanima za ulepšavanje, ali se njihovi aktivni sastojci tek od nedavno koriste za izradu kozmetičkih proizvoda. Kozmetičke sirovine poreklom iz mora najviše se dobijaju iz algi i mikroalgi, mikroorganizama, sunđera i korala. Egzopolisaharidi su novije kozmetičke sirovine koje proizvode morski mikroorganizmi. Navodi se da oni štite kožu od štetnih spoljašnjih uticaja, daju joj mekoću i smanjuju fine linije. Ekstrakti mikroalgi deluju antioksidantno i podstiču sintezu kolagena tipa I. Ekstrakt korala sa pseudopterozinima se koristi za umirivanje kože, dok su morski sunđeri jedan od najvećih alternativnih izvora za dobijanje kolagena. Od svih sirovina poreklom iz mora, alge su najviše istražene i imaju najveći potencijal. Iz algi se dobijaju karagen, agar i alginati, koji se koriste kao humektansi, ugušćivači i gelirajuća sredstva. Aktivni sastojci ekstrakata algi (polisaharidi, proteini, vitamini, minerali) hidriraju kožu, smanjuju fine linije, štite kožu od UV zraka, smanjuju crvenilo kože, a koriste se i u kozmetičkim proizvodima za smanjenje celulita.
AB  - Although some widespread, native cow parsnips (Heracleum L. spp., Apiaceae) had broad medicinal and culinary applications throughout history, the knowledge about their volatile constituents is insufficient. This work investigates the composition and bioactivities of H. sphondylium L. (HSPH), H. sibiricum L. (HSIB) and H. montanum Schleich. ex Gaudin (HMON) essential oils. The composition was tested by GC and GC-MS. (Z)-β-Ocimene was the most abundant in HSPH (28.9%) and HMON (20.4%) root oils, while in HSIB root oil, β-pinene (26.2%), methyl eugenol (22.3%) and elemicin (25.6%) prevailed. Leaf and flower oils were dominated by various sesquiterpenes (germacrene D, β-sesquiphellandrene, (E)-β-farnesene and/or (E)-caryophyllene) and/or phenylpropanoids (apiole, methyl eugenol, elemicin and/or (Z)-isoelemicin). Octyl acetate (57.5-67.1%) was the main constituent of all fruit oils. The antimicrobial activity was screened by a microdilution method against eight bacteria and eight fungi. The strongest antimicrobial effect, in several cases better than the activity of antibiotics, was shown by HSPH (MICs = 0.12-3.30 mg mL-1) and HMON (MICs = 0.10-1.30 mg mL-1) flower oils against bacteria, and HSIB fruit oil against fungi (MICs = 0.15-0.40 mg mL-1). The MTT test revealed that the oils were not or weakly cytotoxic against human malignant HeLa, LS174 and/or A549 cells (except HSPH root oil; IC50 = 5.72-24.31 μg mL-1) and that tested oils were not toxic against human normal MRC-5 cells (at 200.00 μg mL-1). Significant activity observed against microorganisms that are the common cause of foodborne diseases, food contamination and/or hospital-acquired infections justifies certain traditional uses of the investigated plants and represents a good basis for further research of these Heracleum oils.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Cosmetic ingredients from the sea in skin care products
T1  - Kozmetičke sirovine poreklom iz mora u proizvodima za negu kože
VL  - 65
IS  - 5
SP  - 316
EP  - 325
DO  - 10.5937/arhfarm1505316E
ER  - 

@article{
author = "Emeti, Ana and Vasiljević, Dragana and Primorac, Marija and Vuleta, Gordana",
year = "2015",
abstract = "Sea water, salt and mud have been used for centuries in beautification treatments, but their active ingredients have become a recent challenge in formulating new cosmetic products. Cosmetic ingredients which originate from the sea, are mostly obtained from algae, microalgae, marine sponges, corals and microorganisms. Exopolysaccharides (EPS) are new cosmetic ingredients produced by marine micro-organisms. They are used to protect skin from harmful external influences, give it softness and minimize fine lines. Pseudopterosins, present in the extracts of corals, are used to soothe the skin, while marine sponges are one of the major alternative to animal-derived collagen. Algae have been the most researched group, with the greatest potential among different sources of marine ingredients. Carrageenan, agar, and alginates from algae act as humectants, thickeners and gelling agents. The active ingredients of algae extracts (polysaccharides, proteins, vitamins, minerals) could hydrate, minimize fine lines, protect the skin from UV radiation, decrease redness and cellulite., Morska voda, so i mulj koriste se od davnina u tretmanima za ulepšavanje, ali se njihovi aktivni sastojci tek od nedavno koriste za izradu kozmetičkih proizvoda. Kozmetičke sirovine poreklom iz mora najviše se dobijaju iz algi i mikroalgi, mikroorganizama, sunđera i korala. Egzopolisaharidi su novije kozmetičke sirovine koje proizvode morski mikroorganizmi. Navodi se da oni štite kožu od štetnih spoljašnjih uticaja, daju joj mekoću i smanjuju fine linije. Ekstrakti mikroalgi deluju antioksidantno i podstiču sintezu kolagena tipa I. Ekstrakt korala sa pseudopterozinima se koristi za umirivanje kože, dok su morski sunđeri jedan od najvećih alternativnih izvora za dobijanje kolagena. Od svih sirovina poreklom iz mora, alge su najviše istražene i imaju najveći potencijal. Iz algi se dobijaju karagen, agar i alginati, koji se koriste kao humektansi, ugušćivači i gelirajuća sredstva. Aktivni sastojci ekstrakata algi (polisaharidi, proteini, vitamini, minerali) hidriraju kožu, smanjuju fine linije, štite kožu od UV zraka, smanjuju crvenilo kože, a koriste se i u kozmetičkim proizvodima za smanjenje celulita., Although some widespread, native cow parsnips (Heracleum L. spp., Apiaceae) had broad medicinal and culinary applications throughout history, the knowledge about their volatile constituents is insufficient. This work investigates the composition and bioactivities of H. sphondylium L. (HSPH), H. sibiricum L. (HSIB) and H. montanum Schleich. ex Gaudin (HMON) essential oils. The composition was tested by GC and GC-MS. (Z)-β-Ocimene was the most abundant in HSPH (28.9%) and HMON (20.4%) root oils, while in HSIB root oil, β-pinene (26.2%), methyl eugenol (22.3%) and elemicin (25.6%) prevailed. Leaf and flower oils were dominated by various sesquiterpenes (germacrene D, β-sesquiphellandrene, (E)-β-farnesene and/or (E)-caryophyllene) and/or phenylpropanoids (apiole, methyl eugenol, elemicin and/or (Z)-isoelemicin). Octyl acetate (57.5-67.1%) was the main constituent of all fruit oils. The antimicrobial activity was screened by a microdilution method against eight bacteria and eight fungi. The strongest antimicrobial effect, in several cases better than the activity of antibiotics, was shown by HSPH (MICs = 0.12-3.30 mg mL-1) and HMON (MICs = 0.10-1.30 mg mL-1) flower oils against bacteria, and HSIB fruit oil against fungi (MICs = 0.15-0.40 mg mL-1). The MTT test revealed that the oils were not or weakly cytotoxic against human malignant HeLa, LS174 and/or A549 cells (except HSPH root oil; IC50 = 5.72-24.31 μg mL-1) and that tested oils were not toxic against human normal MRC-5 cells (at 200.00 μg mL-1). Significant activity observed against microorganisms that are the common cause of foodborne diseases, food contamination and/or hospital-acquired infections justifies certain traditional uses of the investigated plants and represents a good basis for further research of these Heracleum oils.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Cosmetic ingredients from the sea in skin care products, Kozmetičke sirovine poreklom iz mora u proizvodima za negu kože",
volume = "65",
number = "5",
pages = "316-325",
doi = "10.5937/arhfarm1505316E"
}

Emeti, A., Vasiljević, D., Primorac, M.,& Vuleta, G.. (2015). Cosmetic ingredients from the sea in skin care products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 65(5), 316-325.
https://doi.org/10.5937/arhfarm1505316E

Emeti A, Vasiljević D, Primorac M, Vuleta G. Cosmetic ingredients from the sea in skin care products. in Arhiv za farmaciju. 2015;65(5):316-325.
doi:10.5937/arhfarm1505316E .

Emeti, Ana, Vasiljević, Dragana, Primorac, Marija, Vuleta, Gordana, "Cosmetic ingredients from the sea in skin care products" in Arhiv za farmaciju, 65, no. 5 (2015):316-325,
https://doi.org/10.5937/arhfarm1505316E . .

TY  - JOUR
AU  - Krstić, Marko
AU  - Ražić, Slavica
AU  - Vasiljević, Dragana
AU  - Spasojević, Durdija
AU  - Ibrić, Svetlana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2406
AB  - Poor solubility is one of the key reasons for the poor bioavailability of carbamazepine drugs. This study considers formulation of solid surfactant systems with carbamazepine, in order to increase its dissolution rate. Solid-state surfactant systems were formed by application of fractional experimental design. Poloxamer 237 and Poloxamer 338 were used as the surfactants and Brij (R) 35 was used as the co-surfactant. The ratios of the excipients and carbamazepine were varied and their effects on the dissolution rate of carbamazepine were examined. Moreover, the effects of the addition of natural (diatomite) and a synthetic adsorbent carrier (Neusilin (R) UFL2) on the dissolution rate of carbamazepine were also tested. The prepared surfactant systems were characterized and the influences of the excipients on possible changes of the polymorphous form of carbamazepine examined by application of analytical techniques (DSC, TGA, FT-IR and PXRD). It was determined that an appropriate selection of the excipient type and ratio could provide a significant increase in the carbamazepine dissolution rate. By application of analytical techniques, it was found that the employed excipients induce a transition of carbamazepine into the amorphous form and that the selected sample was stable for three months, when kept under ambient conditions.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis
VL  - 80
IS  - 2
SP  - 209
EP  - 222
DO  - 10.2298/JSC030814114K
ER  - 

@article{
author = "Krstić, Marko and Ražić, Slavica and Vasiljević, Dragana and Spasojević, Durdija and Ibrić, Svetlana",
year = "2015",
abstract = "Poor solubility is one of the key reasons for the poor bioavailability of carbamazepine drugs. This study considers formulation of solid surfactant systems with carbamazepine, in order to increase its dissolution rate. Solid-state surfactant systems were formed by application of fractional experimental design. Poloxamer 237 and Poloxamer 338 were used as the surfactants and Brij (R) 35 was used as the co-surfactant. The ratios of the excipients and carbamazepine were varied and their effects on the dissolution rate of carbamazepine were examined. Moreover, the effects of the addition of natural (diatomite) and a synthetic adsorbent carrier (Neusilin (R) UFL2) on the dissolution rate of carbamazepine were also tested. The prepared surfactant systems were characterized and the influences of the excipients on possible changes of the polymorphous form of carbamazepine examined by application of analytical techniques (DSC, TGA, FT-IR and PXRD). It was determined that an appropriate selection of the excipient type and ratio could provide a significant increase in the carbamazepine dissolution rate. By application of analytical techniques, it was found that the employed excipients induce a transition of carbamazepine into the amorphous form and that the selected sample was stable for three months, when kept under ambient conditions.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis",
volume = "80",
number = "2",
pages = "209-222",
doi = "10.2298/JSC030814114K"
}

Krstić, M., Ražić, S., Vasiljević, D., Spasojević, D.,& Ibrić, S.. (2015). Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 80(2), 209-222.
https://doi.org/10.2298/JSC030814114K

Krstić M, Ražić S, Vasiljević D, Spasojević D, Ibrić S. Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis. in Journal of the Serbian Chemical Society. 2015;80(2):209-222.
doi:10.2298/JSC030814114K .

Krstić, Marko, Ražić, Slavica, Vasiljević, Dragana, Spasojević, Durdija, Ibrić, Svetlana, "Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis" in Journal of the Serbian Chemical Society, 80, no. 2 (2015):209-222,
https://doi.org/10.2298/JSC030814114K . .

TY  - JOUR
AU  - Drakul, Dragana
AU  - Matić, Predrag
AU  - Drobac, Milica
AU  - Kostić, Nađa
AU  - Vemić, Ana
AU  - Vasiljević, Dragana
AU  - Malenović, Anđelija
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2291
AB  - Vascular stents are general medical devices of class III or IIb, which are placed along the walls of the constricted coronary and peripheral blood vessels thus keeping them viable. According to the mechanism of expansion, stents may be balloon-expandable or self-expanding. Depending on the geometry they can be classified into: coil stents, open-cell modular stents and multi-cell closed cell stents. The most important characteristic of vascular stents is their flexibility, but a number of additional requirements must also be met: high radial strength, low elastic deformation, small diameter, the possibility of monitoring through the bloodstream, minimum subsequent shortening, minimum elastic longitudinal deformation, and the optimal retention at target site. Materials for production of stents must be biologically inert, visible by radiological techniques, biocompatible, corrosion-resistant and resistant to stress due to blood flow. The most significant adverse event after stent implantation is the occurrence of restenosis, which is most efficiently overcome by the application of drug releasing stents. These stents are composed of three parts: stent platform, drug carrier and a drug that inhibits neointimal hyperplasia - paclitaxel and limuses (sirolimus, everolimus, zotarolimus, tacrolimus, pimecrolimus, etc.). In recent years, stents with surfaces coated with substances that accelerate endothelialisation and thus reduce thrombosis have been developed. The latest approach is represented by a stent with the lumen coated with CD34 antibody, and the outer side coated with sirolimus. By using these devices a double effect is achieved: acceleration of endothelialisation and inhibition of neointimal hyperplasia.
AB  - Vaskularni stentovi su opšta medicinska sredstva klase III ili IIb, koja se postavljaju uz zidove koronarnih i perifernih krvnih sudova kada postoji suženje i na taj način ih održavaju prohodnim. Prema mehanizmu ekspanzije, stentovi mogu biti balon-ekspandirajući ili samoekspandirajući, a u zavisnosti od geometrijskog oblika dele se na: stentove u obliku spirale, modularne stentove sa otvorenim ćelijama i multićelijske stentove sa zatvorenim ćelijama. Najznačajnija karakteristika vaskularnih stentova je fleksibilnost, ali moraju da ispunjavaju i čitav niz dodatnih zahteva, kao što su: velika radijalna snaga, nizak stepen elastične deformacije, mali prečnik, mogućnost praćenja kroz krvotok, minimalno naknadno skraćivanje, minimalna elastična longitudinalna deformacija i optimalno zadržavanje na ciljnom mestu. Materijali za proizvodnju stentova moraju biti biološki inertni, vidljivi radiološkim tehnikama, biokompatibilni, otporni na koroziju i otporni na stres zbog protoka krvi. Najznačajniji neželjeni događaj nakon ugradnje stentova je pojava restenoze, koja se najefikasnije prevazilazi primenom stentova koji oslobađaju lek. Ovi stentovi se sastoje iz tri dela: platforme stenta, nosača leka i leka koji inhibira neointimalnu hiperplaziju, paklitaksel i limusi (sirolimus, everolimus, zotarolimus, takrolimus, pimekrolimus i dr). Poslednjih godina razvijeni su i stentovi kod kojih se površine oblažu supstancama koje ubrzavaju endotelizaciju i tako smanjuju trombozu. Najnoviji pristup predstavlja stent kod koga se lumen stenta oblaže CD34 antitelom, a spoljašnja strana sirolimusom. Primenom ovih stentova postiže se dvostruki efekat: ubrzavanje endotelizacije i inhibicija neointimalne hiperplazije.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Vascular stents: The most important types and characteristics
T1  - Vaskularni stentovi - najznačajnije vrste i osobine
VL  - 64
IS  - 5
SP  - 421
EP  - 437
DO  - 10.5937/arhfarm1405421D
ER  - 

@article{
author = "Drakul, Dragana and Matić, Predrag and Drobac, Milica and Kostić, Nađa and Vemić, Ana and Vasiljević, Dragana and Malenović, Anđelija",
year = "2014",
abstract = "Vascular stents are general medical devices of class III or IIb, which are placed along the walls of the constricted coronary and peripheral blood vessels thus keeping them viable. According to the mechanism of expansion, stents may be balloon-expandable or self-expanding. Depending on the geometry they can be classified into: coil stents, open-cell modular stents and multi-cell closed cell stents. The most important characteristic of vascular stents is their flexibility, but a number of additional requirements must also be met: high radial strength, low elastic deformation, small diameter, the possibility of monitoring through the bloodstream, minimum subsequent shortening, minimum elastic longitudinal deformation, and the optimal retention at target site. Materials for production of stents must be biologically inert, visible by radiological techniques, biocompatible, corrosion-resistant and resistant to stress due to blood flow. The most significant adverse event after stent implantation is the occurrence of restenosis, which is most efficiently overcome by the application of drug releasing stents. These stents are composed of three parts: stent platform, drug carrier and a drug that inhibits neointimal hyperplasia - paclitaxel and limuses (sirolimus, everolimus, zotarolimus, tacrolimus, pimecrolimus, etc.). In recent years, stents with surfaces coated with substances that accelerate endothelialisation and thus reduce thrombosis have been developed. The latest approach is represented by a stent with the lumen coated with CD34 antibody, and the outer side coated with sirolimus. By using these devices a double effect is achieved: acceleration of endothelialisation and inhibition of neointimal hyperplasia., Vaskularni stentovi su opšta medicinska sredstva klase III ili IIb, koja se postavljaju uz zidove koronarnih i perifernih krvnih sudova kada postoji suženje i na taj način ih održavaju prohodnim. Prema mehanizmu ekspanzije, stentovi mogu biti balon-ekspandirajući ili samoekspandirajući, a u zavisnosti od geometrijskog oblika dele se na: stentove u obliku spirale, modularne stentove sa otvorenim ćelijama i multićelijske stentove sa zatvorenim ćelijama. Najznačajnija karakteristika vaskularnih stentova je fleksibilnost, ali moraju da ispunjavaju i čitav niz dodatnih zahteva, kao što su: velika radijalna snaga, nizak stepen elastične deformacije, mali prečnik, mogućnost praćenja kroz krvotok, minimalno naknadno skraćivanje, minimalna elastična longitudinalna deformacija i optimalno zadržavanje na ciljnom mestu. Materijali za proizvodnju stentova moraju biti biološki inertni, vidljivi radiološkim tehnikama, biokompatibilni, otporni na koroziju i otporni na stres zbog protoka krvi. Najznačajniji neželjeni događaj nakon ugradnje stentova je pojava restenoze, koja se najefikasnije prevazilazi primenom stentova koji oslobađaju lek. Ovi stentovi se sastoje iz tri dela: platforme stenta, nosača leka i leka koji inhibira neointimalnu hiperplaziju, paklitaksel i limusi (sirolimus, everolimus, zotarolimus, takrolimus, pimekrolimus i dr). Poslednjih godina razvijeni su i stentovi kod kojih se površine oblažu supstancama koje ubrzavaju endotelizaciju i tako smanjuju trombozu. Najnoviji pristup predstavlja stent kod koga se lumen stenta oblaže CD34 antitelom, a spoljašnja strana sirolimusom. Primenom ovih stentova postiže se dvostruki efekat: ubrzavanje endotelizacije i inhibicija neointimalne hiperplazije.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Vascular stents: The most important types and characteristics, Vaskularni stentovi - najznačajnije vrste i osobine",
volume = "64",
number = "5",
pages = "421-437",
doi = "10.5937/arhfarm1405421D"
}

Drakul, D., Matić, P., Drobac, M., Kostić, N., Vemić, A., Vasiljević, D.,& Malenović, A.. (2014). Vascular stents: The most important types and characteristics. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(5), 421-437.
https://doi.org/10.5937/arhfarm1405421D

Drakul D, Matić P, Drobac M, Kostić N, Vemić A, Vasiljević D, Malenović A. Vascular stents: The most important types and characteristics. in Arhiv za farmaciju. 2014;64(5):421-437.
doi:10.5937/arhfarm1405421D .

Drakul, Dragana, Matić, Predrag, Drobac, Milica, Kostić, Nađa, Vemić, Ana, Vasiljević, Dragana, Malenović, Anđelija, "Vascular stents: The most important types and characteristics" in Arhiv za farmaciju, 64, no. 5 (2014):421-437,
https://doi.org/10.5937/arhfarm1405421D . .