TY  - CONF
AU  - Medarević, Đorđe
AU  - Turković, Erna
AU  - Čežek, Maša
AU  - Ibrić, Svetlana
AU  - Maksimović, Zoran
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5606
AB  - INTRODUCTION
Crop residues (CRs) represent a resource that is available in
virtually unlimited quantities, but still the largest part
remains unused. Unfortunately, CRs are usually burned in
the field, which causes air pollution, contributes to global
warming by emitting greenhouse gasses, hinders nutrient
recycling, and negatively affects soil microbes through
overheating and carbon loss [1]. One of the most important
value-added components that can be isolated from CRs is
microcrystalline cellulose (MCC), a common excipient in
tablet formulation. In this study, a comparative evaluation
of tableting properties of MCC obtained from wheat and
corn CRs by different chemical treatment was performed. ...
PB  - International Association for Pharmaceutical Technology (APV), Mainz, Germany
PB  - International Society of Drug Delivery Sciences and Technology (APGI), Lille, France
PB  - Italian Society of Technology and Legislation (S.I.T.E.L.F), Milan, Italy
C3  - 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria
T1  - Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5606
ER  - 

@conference{
author = "Medarević, Đorđe and Turković, Erna and Čežek, Maša and Ibrić, Svetlana and Maksimović, Zoran",
year = "2024",
abstract = "INTRODUCTION
Crop residues (CRs) represent a resource that is available in
virtually unlimited quantities, but still the largest part
remains unused. Unfortunately, CRs are usually burned in
the field, which causes air pollution, contributes to global
warming by emitting greenhouse gasses, hinders nutrient
recycling, and negatively affects soil microbes through
overheating and carbon loss [1]. One of the most important
value-added components that can be isolated from CRs is
microcrystalline cellulose (MCC), a common excipient in
tablet formulation. In this study, a comparative evaluation
of tableting properties of MCC obtained from wheat and
corn CRs by different chemical treatment was performed. ...",
publisher = "International Association for Pharmaceutical Technology (APV), Mainz, Germany, International Society of Drug Delivery Sciences and Technology (APGI), Lille, France, Italian Society of Technology and Legislation (S.I.T.E.L.F), Milan, Italy",
journal = "14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria",
title = "Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5606"
}

Medarević, Đ., Turković, E., Čežek, M., Ibrić, S.,& Maksimović, Z.. (2024). Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria
International Association for Pharmaceutical Technology (APV), Mainz, Germany..
https://hdl.handle.net/21.15107/rcub_farfar_5606

Medarević Đ, Turković E, Čežek M, Ibrić S, Maksimović Z. Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues. in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria. 2024;.
https://hdl.handle.net/21.15107/rcub_farfar_5606 .

Medarević, Đorđe, Turković, Erna, Čežek, Maša, Ibrić, Svetlana, Maksimović, Zoran, "Comparative evaluation of tableting properties of microcrystalline cellulose obtained from wheat and corn crop residues" in 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 18 - 21 March 2024, Vienna, Austria (2024),
https://hdl.handle.net/21.15107/rcub_farfar_5606 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5319
AB  - Oralno-disperzibilne tablete (ODT) predstavljaju relativno nove čvrste farmaceutske oblike koji  se  brzo  raspadaju  u  usnoj  duplji,  bez  dodatkavode (1). Cilj ovog istraživanja bio je da se analiziraju ODT preparati dostupni na tržištu evropskih zemalja (Nemačka, SŠpanija, Slovenija, Hrvatska, Srbija). Istraživanje je zasnovano na pretrazi komercijalno dostupnih ODT-a  i  njihovog  sastava. Utvrđeno je da je u Nemačkoj dostupno 563 preparata tipa ODT (28 različitih lekovitih supstanci),  dok  je  u  Srbiji  prisutno  samo  19  ODT-a (8 različitih lekovitih supstanci). Većina ODT preparata sadrži lekovite supstance iz grupe antipsihotika (26,6–54,2%), najčešće olanzapin, što se može objasniti boljim prihvatanjem terapije. Izuzetak je SŠpanija, gde su ODT  sa  antimigrenicima  najčešće (22,3%), verovatno usled lakše primene i gutanja ODT preparata (1,2). Analizom sastava ODT-a primećeno je da se kombinacija manitol-mikrokristalna celuloza najčešće dodaje kao sredstvo za dopunjavanje (69,1%). Brza dezintegracija, kao kritično svojstvo kvaliteta ODT-a, postiže se različitim pristupima. Većina preparata (66,0%) sadrži krospovidon kao superdezintegrator. Prijatan ukus ODT obezbeđen je kombinovanjem zaslađivača i aroma. Aspartam je veoma zastupljen u preparatima (74,2%), i do devet puta češće od ostalih zaslađivača. Veća razlika među preparatima uočena je u slučaju aroma: komercijalno dostupne ODT sadržale su aromu peperminta (39,2%), pomorandže (20,6%), itd. Međutim, 17,5% ODT nije sadržalo aromu, što ukazuje da je prijatan ukus postignut pomoću sredstva za dopunjavanje i zaslađivača (npr. manitol, saharoza). Veliki broj komercijalno  dostupnih  ODT  preparata  ukazuje  na  prednosti  za  pacijente,  posebno  u  slučaju psihijatrijskih bolesti i migrene. Tipičan predstavnik ODT preparata na tržištu sadrži manitol-mikrokristalnu celulozu, krospovidon, aspartam i aromu.
AB  - Orodispersible tablets (ODTs) are relatively new solid dosage forms that disintegrate rapidly in the oral cavity, without the addition of water (1). The aim of this research was to analyze ODTs available  on  the  market  in  representative  European  countries  (Germany, Spain, Slovenia, Croatia, Serbia).  The  research  was  based  on  investigation  of  commercially  available  ODTs  and  their composition. In Germany, 563 ODT products are available (28 different active ingredients), while only 19  ODTs  are  present  in  Serbia(8 different active ingredients). The majority of ODTs contain antipsychotic  drugs  (26.6–54.2%),  particularly olanzapine,  presumably  due  to  better  patient compliance. The only exception is Spain, where antimigraine ODTs are the most frequent (22.3%), which may be attributed to easier administration and swallowing (1,2). Regarding ODT composition, the mannitol-microcrystalline cellulose combination was mostly used as a filler/diluent (69.1%). Fast disintegration, as ODT critical quality attribute, is achieved by different approaches. Crospovidone was found in the majority of formulations (66.0%). In order to ensure apleasant taste, sweeteners and flavors are combined. Aspartame was present up to nine times more than other sweeteners (74.2%). More flexibility was observed regarding flavoring and ODTs contained peppermint (39.2%), orange (20.6%), etc. However, 17.5% of products contained no flavoring, indicating that pleasant taste was achieved by fillers and sweeteners, e.g., mannitol and sucrose. The high number  of  ODTs  available on the market indicates the advantages for patients, particularly in the case of psychiatric diseases  and  migraine.  A  typical  ODT  product  contains  mannitol-microcrystalline  cellulose, crospovidone, aspartame and a flavor.
PB  - Savez farmaceutskih udruženja Srbije
C3  - Arhiv za farmaciju
T1  - Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope
T1  - An investigation into representation and composition of commercially available orodispersible tablets on the market of European countries
VL  - 73
IS  - Suppl. 4
SP  - S61
EP  - S62
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5319
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena",
year = "2023",
abstract = "Oralno-disperzibilne tablete (ODT) predstavljaju relativno nove čvrste farmaceutske oblike koji  se  brzo  raspadaju  u  usnoj  duplji,  bez  dodatkavode (1). Cilj ovog istraživanja bio je da se analiziraju ODT preparati dostupni na tržištu evropskih zemalja (Nemačka, SŠpanija, Slovenija, Hrvatska, Srbija). Istraživanje je zasnovano na pretrazi komercijalno dostupnih ODT-a  i  njihovog  sastava. Utvrđeno je da je u Nemačkoj dostupno 563 preparata tipa ODT (28 različitih lekovitih supstanci),  dok  je  u  Srbiji  prisutno  samo  19  ODT-a (8 različitih lekovitih supstanci). Većina ODT preparata sadrži lekovite supstance iz grupe antipsihotika (26,6–54,2%), najčešće olanzapin, što se može objasniti boljim prihvatanjem terapije. Izuzetak je SŠpanija, gde su ODT  sa  antimigrenicima  najčešće (22,3%), verovatno usled lakše primene i gutanja ODT preparata (1,2). Analizom sastava ODT-a primećeno je da se kombinacija manitol-mikrokristalna celuloza najčešće dodaje kao sredstvo za dopunjavanje (69,1%). Brza dezintegracija, kao kritično svojstvo kvaliteta ODT-a, postiže se različitim pristupima. Većina preparata (66,0%) sadrži krospovidon kao superdezintegrator. Prijatan ukus ODT obezbeđen je kombinovanjem zaslađivača i aroma. Aspartam je veoma zastupljen u preparatima (74,2%), i do devet puta češće od ostalih zaslađivača. Veća razlika među preparatima uočena je u slučaju aroma: komercijalno dostupne ODT sadržale su aromu peperminta (39,2%), pomorandže (20,6%), itd. Međutim, 17,5% ODT nije sadržalo aromu, što ukazuje da je prijatan ukus postignut pomoću sredstva za dopunjavanje i zaslađivača (npr. manitol, saharoza). Veliki broj komercijalno  dostupnih  ODT  preparata  ukazuje  na  prednosti  za  pacijente,  posebno  u  slučaju psihijatrijskih bolesti i migrene. Tipičan predstavnik ODT preparata na tržištu sadrži manitol-mikrokristalnu celulozu, krospovidon, aspartam i aromu., Orodispersible tablets (ODTs) are relatively new solid dosage forms that disintegrate rapidly in the oral cavity, without the addition of water (1). The aim of this research was to analyze ODTs available  on  the  market  in  representative  European  countries  (Germany, Spain, Slovenia, Croatia, Serbia).  The  research  was  based  on  investigation  of  commercially  available  ODTs  and  their composition. In Germany, 563 ODT products are available (28 different active ingredients), while only 19  ODTs  are  present  in  Serbia(8 different active ingredients). The majority of ODTs contain antipsychotic  drugs  (26.6–54.2%),  particularly olanzapine,  presumably  due  to  better  patient compliance. The only exception is Spain, where antimigraine ODTs are the most frequent (22.3%), which may be attributed to easier administration and swallowing (1,2). Regarding ODT composition, the mannitol-microcrystalline cellulose combination was mostly used as a filler/diluent (69.1%). Fast disintegration, as ODT critical quality attribute, is achieved by different approaches. Crospovidone was found in the majority of formulations (66.0%). In order to ensure apleasant taste, sweeteners and flavors are combined. Aspartame was present up to nine times more than other sweeteners (74.2%). More flexibility was observed regarding flavoring and ODTs contained peppermint (39.2%), orange (20.6%), etc. However, 17.5% of products contained no flavoring, indicating that pleasant taste was achieved by fillers and sweeteners, e.g., mannitol and sucrose. The high number  of  ODTs  available on the market indicates the advantages for patients, particularly in the case of psychiatric diseases  and  migraine.  A  typical  ODT  product  contains  mannitol-microcrystalline  cellulose, crospovidone, aspartame and a flavor.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope, An investigation into representation and composition of commercially available orodispersible tablets on the market of European countries",
volume = "73",
number = "Suppl. 4",
pages = "S61-S62",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5319"
}

Vasiljević, I., Turković, E.,& Parojčić, J.. (2023). Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije., 73(Suppl. 4), S61-S62.
https://hdl.handle.net/21.15107/rcub_farfar_5319

Vasiljević I, Turković E, Parojčić J. Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope. in Arhiv za farmaciju. 2023;73(Suppl. 4):S61-S62.
https://hdl.handle.net/21.15107/rcub_farfar_5319 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, "Analiza zastupljenosti i sastava oralno-disperzibilnih tableta dostupnih na tržištu zemalja evrope" in Arhiv za farmaciju, 73, no. Suppl. 4 (2023):S61-S62,
https://hdl.handle.net/21.15107/rcub_farfar_5319 .

TY  - CONF
AU  - Turković, Erna
AU  - Velkoska, Elena
AU  - Nančeva, Ana Marija
AU  - Vasiljević, Ivana
AU  - Goračinova, Katerina
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5073
AB  - Semi-solid 3D printing technology has gained
increased interest in the pharmaceutical field as it enables
on-demand fabrication of personalized dosage forms.
Orodispersible films (ODFs) are good candidates for 3D
printing because of their relatively simple formulation,
flexible dosing, and suitability for administration in
different populations. The aim of this work was to
investigate the applicability of sodium carboxymethyl
cellulose and sodium alginate as film-forming agents for
3D printed ODFs incorporating amlodipine or warfarin as
selected model active pharmaceutical ingredients (API).
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing
VL  - 69
IS  - Suppl 1
SP  - 291
EP  - 292
DO  - 10.33320/maced.pharm.bull.2023.69.03.141
ER  - 

@conference{
author = "Turković, Erna and Velkoska, Elena and Nančeva, Ana Marija and Vasiljević, Ivana and Goračinova, Katerina and Parojčić, Jelena",
year = "2023",
abstract = "Semi-solid 3D printing technology has gained
increased interest in the pharmaceutical field as it enables
on-demand fabrication of personalized dosage forms.
Orodispersible films (ODFs) are good candidates for 3D
printing because of their relatively simple formulation,
flexible dosing, and suitability for administration in
different populations. The aim of this work was to
investigate the applicability of sodium carboxymethyl
cellulose and sodium alginate as film-forming agents for
3D printed ODFs incorporating amlodipine or warfarin as
selected model active pharmaceutical ingredients (API).",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing",
volume = "69",
number = "Suppl 1",
pages = "291-292",
doi = "10.33320/maced.pharm.bull.2023.69.03.141"
}

Turković, E., Velkoska, E., Nančeva, A. M., Vasiljević, I., Goračinova, K.,& Parojčić, J.. (2023). An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 291-292.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.141

Turković E, Velkoska E, Nančeva AM, Vasiljević I, Goračinova K, Parojčić J. An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):291-292.
doi:10.33320/maced.pharm.bull.2023.69.03.141 .

Turković, Erna, Velkoska, Elena, Nančeva, Ana Marija, Vasiljević, Ivana, Goračinova, Katerina, Parojčić, Jelena, "An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):291-292,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.141 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Pasik, Paulina
AU  - Turković, Erna
AU  - Ivković, Branka
AU  - Hejduk, Arkadiusz
AU  - Lulek, Janina
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5072
AB  - Direct compression represents a favorable tablet
manufacturing method. However, obtaining satisfactory
mechanical properties of the compacts and drug dissolution
remains a challenge in formulation development,
particularly in the case of challenging model drugs.
Rivaroxaban is classified as a class II model drug
according to the Biopharmaceutical Classification System
and exhibits prominent cohesiveness and low aqueous
solubility (Choi et al., 2022). The aim of this work was to
evaluate the influence of different directly compressible
fillers/diluents on selected compact properties (namely,
tensile strength, friability, and disintegration) and the
dissolution of rivaroxaban from the prepared compacts.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban
VL  - 69
IS  - Suppl 1
SP  - 289
EP  - 290
DO  - 10.33320/maced.pharm.bull.2023.69.03.140
ER  - 

@conference{
author = "Vasiljević, Ivana and Pasik, Paulina and Turković, Erna and Ivković, Branka and Hejduk, Arkadiusz and Lulek, Janina and Parojčić, Jelena",
year = "2023",
abstract = "Direct compression represents a favorable tablet
manufacturing method. However, obtaining satisfactory
mechanical properties of the compacts and drug dissolution
remains a challenge in formulation development,
particularly in the case of challenging model drugs.
Rivaroxaban is classified as a class II model drug
according to the Biopharmaceutical Classification System
and exhibits prominent cohesiveness and low aqueous
solubility (Choi et al., 2022). The aim of this work was to
evaluate the influence of different directly compressible
fillers/diluents on selected compact properties (namely,
tensile strength, friability, and disintegration) and the
dissolution of rivaroxaban from the prepared compacts.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban",
volume = "69",
number = "Suppl 1",
pages = "289-290",
doi = "10.33320/maced.pharm.bull.2023.69.03.140"
}

Vasiljević, I., Pasik, P., Turković, E., Ivković, B., Hejduk, A., Lulek, J.,& Parojčić, J.. (2023). The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 289-290.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.140

Vasiljević I, Pasik P, Turković E, Ivković B, Hejduk A, Lulek J, Parojčić J. The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):289-290.
doi:10.33320/maced.pharm.bull.2023.69.03.140 .

Vasiljević, Ivana, Pasik, Paulina, Turković, Erna, Ivković, Branka, Hejduk, Arkadiusz, Lulek, Janina, Parojčić, Jelena, "The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):289-290,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.140 . .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5064
AB  - Thin films are polymeric strips that disintegrate in the
oral cavity and consist of a film-forming agent and an
active pharmaceutical ingredient (API). Generally, thin
films disintegrate within seconds, but their composition
can be modified to allow slower disintegration and release
of the loaded API, depending on the properties of the film.
Research into various aspects of oral thin films is
progressing rapidly, but thin films are also being discussed
in the context of a broader range of other dosage forms,
such as carrier for multiparticulates or nano-based dosage
forms and for the fixed-dose combinations (Turković et al.,
2022). Large amounts of data are being generated over the
years, so integrating machine learning algorithms can be
beneficial to gain more in-depth knowledge about the thin
film properties and interactions between film constituents.
Gradient boosted tree is one of machine learning tools that
perform regression or classification by combining the
outputs from individual decision trees. This work is aimed
to explore the possibility of integrating a machine learning
approach in evaluation of experimental data obtained by
films characterization. Potential application of Gradient
boosted trees for thin films characterization based on their
disintegration properties as film critical quality attribute
was investigated.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Application of the Gradient boosted tree approach for thin film classification based on disintegration time
VL  - 69
IS  - Suppl 1
SP  - 113
EP  - 114
DO  - 10.33320/maced.pharm.bull.2023.69.03.055
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Parojčić, Jelena",
year = "2023",
abstract = "Thin films are polymeric strips that disintegrate in the
oral cavity and consist of a film-forming agent and an
active pharmaceutical ingredient (API). Generally, thin
films disintegrate within seconds, but their composition
can be modified to allow slower disintegration and release
of the loaded API, depending on the properties of the film.
Research into various aspects of oral thin films is
progressing rapidly, but thin films are also being discussed
in the context of a broader range of other dosage forms,
such as carrier for multiparticulates or nano-based dosage
forms and for the fixed-dose combinations (Turković et al.,
2022). Large amounts of data are being generated over the
years, so integrating machine learning algorithms can be
beneficial to gain more in-depth knowledge about the thin
film properties and interactions between film constituents.
Gradient boosted tree is one of machine learning tools that
perform regression or classification by combining the
outputs from individual decision trees. This work is aimed
to explore the possibility of integrating a machine learning
approach in evaluation of experimental data obtained by
films characterization. Potential application of Gradient
boosted trees for thin films characterization based on their
disintegration properties as film critical quality attribute
was investigated.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Application of the Gradient boosted tree approach for thin film classification based on disintegration time",
volume = "69",
number = "Suppl 1",
pages = "113-114",
doi = "10.33320/maced.pharm.bull.2023.69.03.055"
}

Turković, E., Vasiljević, I.,& Parojčić, J.. (2023). Application of the Gradient boosted tree approach for thin film classification based on disintegration time. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 113-114.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.055

Turković E, Vasiljević I, Parojčić J. Application of the Gradient boosted tree approach for thin film classification based on disintegration time. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):113-114.
doi:10.33320/maced.pharm.bull.2023.69.03.055 .

Turković, Erna, Vasiljević, Ivana, Parojčić, Jelena, "Application of the Gradient boosted tree approach for thin film classification based on disintegration time" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):113-114,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.055 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5052
AB  - Multiparticulate unit systems (MPUs) represent
versatile drug delivery systems which provide flexible
dosing and reproducible drug release profile (Al-Hashimi
et al., 2018). They are usually filled in capsules/sachets or
compressed into tablets, and, in order to ensure good
processability, thorough MPU characterization is required.
The aim of this work was to explore the impact of
composition and preparation method on MPU
characteristics and identify potential patterns between the
data using advanced computational analysis. ...
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Data mining implementation in multiparticulate unit systems characterization
VL  - 69
IS  - Suppl 1
SP  - 103
EP  - 104
DO  - 10.33320/maced.pharm.bull.2023.69.03.050
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena",
year = "2023",
abstract = "Multiparticulate unit systems (MPUs) represent
versatile drug delivery systems which provide flexible
dosing and reproducible drug release profile (Al-Hashimi
et al., 2018). They are usually filled in capsules/sachets or
compressed into tablets, and, in order to ensure good
processability, thorough MPU characterization is required.
The aim of this work was to explore the impact of
composition and preparation method on MPU
characteristics and identify potential patterns between the
data using advanced computational analysis. ...",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Data mining implementation in multiparticulate unit systems characterization",
volume = "69",
number = "Suppl 1",
pages = "103-104",
doi = "10.33320/maced.pharm.bull.2023.69.03.050"
}

Vasiljević, I., Turković, E.,& Parojčić, J.. (2023). Data mining implementation in multiparticulate unit systems characterization. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 103-104.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.050

Vasiljević I, Turković E, Parojčić J. Data mining implementation in multiparticulate unit systems characterization. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):103-104.
doi:10.33320/maced.pharm.bull.2023.69.03.050 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, "Data mining implementation in multiparticulate unit systems characterization" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):103-104,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.050 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Ibrić, Svetlana
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5318
AB  - Expert System for Drug Development, i.e. SeDeM
Expert System (Span. Sistema Experto para DEsarrollo
de Medicamentos) represents a method intended for
evaluation of powder properties affecting processability,
particularly compression behavior (Pérez et al., 2006).
Additionally, it is recognized as useful formulation tool,
since it provides identification of impaired powder
properties and facilitates formulation development
suitable for direct compression, based on mathematical
equations. Relevant parameters described in SeDeM
Expert System are divided into 5 groups and denoted as
“incidence factors”, namely: Density, Compression,
Flowability, Particle Size and Stability (Aguilar-Díaz et
al., 2014).
The aim of this work was to investigate mannitol-
and lactose-based co-processed excipients, based on
SeDeM Expert System methodology, and assess its
suitability for compressible formulation development. ...
PB  - Macedonian Pharmaceutical Association
PB  - Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje
C3  - Macedonian Pharmaceutical Bulletin
T1  - Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development
VL  - 68
IS  - Suppl 1
SP  - 223
EP  - 224
DO  - 10.33320/maced.pharm.bull.2022.68.03.106
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Ibrić, Svetlana and Vasiljević, Dragana and Parojčić, Jelena",
year = "2022",
abstract = "Expert System for Drug Development, i.e. SeDeM
Expert System (Span. Sistema Experto para DEsarrollo
de Medicamentos) represents a method intended for
evaluation of powder properties affecting processability,
particularly compression behavior (Pérez et al., 2006).
Additionally, it is recognized as useful formulation tool,
since it provides identification of impaired powder
properties and facilitates formulation development
suitable for direct compression, based on mathematical
equations. Relevant parameters described in SeDeM
Expert System are divided into 5 groups and denoted as
“incidence factors”, namely: Density, Compression,
Flowability, Particle Size and Stability (Aguilar-Díaz et
al., 2014).
The aim of this work was to investigate mannitol-
and lactose-based co-processed excipients, based on
SeDeM Expert System methodology, and assess its
suitability for compressible formulation development. ...",
publisher = "Macedonian Pharmaceutical Association, Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development",
volume = "68",
number = "Suppl 1",
pages = "223-224",
doi = "10.33320/maced.pharm.bull.2022.68.03.106"
}

Vasiljević, I., Turković, E., Ibrić, S., Vasiljević, D.,& Parojčić, J.. (2022). Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 68(Suppl 1), 223-224.
https://doi.org/10.33320/maced.pharm.bull.2022.68.03.106

Vasiljević I, Turković E, Ibrić S, Vasiljević D, Parojčić J. Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development. in Macedonian Pharmaceutical Bulletin. 2022;68(Suppl 1):223-224.
doi:10.33320/maced.pharm.bull.2022.68.03.106 .

Vasiljević, Ivana, Turković, Erna, Ibrić, Svetlana, Vasiljević, Dragana, Parojčić, Jelena, "Applicability of Expert System for Drug Development as a tool for co-processed excipients formulation development" in Macedonian Pharmaceutical Bulletin, 68, no. Suppl 1 (2022):223-224,
https://doi.org/10.33320/maced.pharm.bull.2022.68.03.106 . .

TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4336
AB  - Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.
PB  - Elsevier B.V.
T2  - Journal of Drug Delivery Science and Technology
T1  - Orodispersible films — Pharmaceutical development for improved performance: A review
VL  - 75
DO  - 10.1016/j.jddst.2022.103708
ER  - 

@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Parojčić, Jelena",
year = "2022",
abstract = "Orodispersible films (ODFs) have recently emerged as innovative dosage form which provides distinct advantages in the patient centric pharmaceutical drug product design due to inherent dosing flexibility and improved patient acceptability. Although their potential advantages in pharmacotherapy are well recognized, there is still a lot of research work to be done in order to explore and understand complex relationships among different formulation factors, film mechanical properties, and their bioperformance. Lack of standardized characterization methods and relevant specifications pose additional limitation for their wider application. In the present study, in-depth review of the available body of data published on ODF development and characterization was performed. In total, 112 papers published between November 2008 and April 2022 were taken into consideration for dataset building. Data collected have been critically evaluated and compiled into the representative dataset formed around three domains, namely: (A) Manufacturing method and composition; (B) ODF characteristics; and (C) ODF sensory attributes. Based on the investigated dataset, an attempt was made to identify the acceptable range of Critical Quality Attributes (CQA) values and propose ODF specific Quality Targeted Product Profile (QTPP) as a foundation which should guide and facilitate pharmaceutical development.",
publisher = "Elsevier B.V.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Orodispersible films — Pharmaceutical development for improved performance: A review",
volume = "75",
doi = "10.1016/j.jddst.2022.103708"
}

Turković, E., Vasiljević, I., Drašković, M.,& Parojčić, J.. (2022). Orodispersible films — Pharmaceutical development for improved performance: A review. in Journal of Drug Delivery Science and Technology
Elsevier B.V.., 75.
https://doi.org/10.1016/j.jddst.2022.103708

Turković E, Vasiljević I, Drašković M, Parojčić J. Orodispersible films — Pharmaceutical development for improved performance: A review. in Journal of Drug Delivery Science and Technology. 2022;75.
doi:10.1016/j.jddst.2022.103708 .

Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Parojčić, Jelena, "Orodispersible films — Pharmaceutical development for improved performance: A review" in Journal of Drug Delivery Science and Technology, 75 (2022),
https://doi.org/10.1016/j.jddst.2022.103708 . .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Piller, Michael
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4318
AB  - 3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), using different polymers, and investigate their processability based on the SeDeM Expert System approach. MPUs (1- or 2-mm size) were prepared with model drug (ibuprofen or caffeine), polymer (poly(ethylene)oxide (PEO), ethyl cellulose (EC) or methacrylic acid-ethyl acrylate copolymer (MA-EA)) and printing aid. Comprehensive sample characterization was performed and experimentally obtained parameters were mathematically transformed and evaluated using the SeDeM Expert System framework. The obtained samples exhibited irregular shape, despite the spherical printing object design. Polymer incorporated notably affected MPUs properties. The obtained samples exhibited low bulk density, good flowability-, as well as stability-related parameters, which indicated their suitability for filling into capsules or sachets. Low density values implied that compressibility enhancing excipients may be required for MPUs incorporation in tablets. Samples containing EC and MA-EA were found suitable for compression, due to high compacts tensile strength. The obtained results indicate that SeDeM Expert System may extended from powder compressibility evaluation tool to framework facilitating powders/multiparticulate units processing.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach
VL  - 629
DO  - 10.1016/j.ijpharm.2022.122337
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Piller, Michael and Mirković, Miljana and Zimmer, Andreas and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), using different polymers, and investigate their processability based on the SeDeM Expert System approach. MPUs (1- or 2-mm size) were prepared with model drug (ibuprofen or caffeine), polymer (poly(ethylene)oxide (PEO), ethyl cellulose (EC) or methacrylic acid-ethyl acrylate copolymer (MA-EA)) and printing aid. Comprehensive sample characterization was performed and experimentally obtained parameters were mathematically transformed and evaluated using the SeDeM Expert System framework. The obtained samples exhibited irregular shape, despite the spherical printing object design. Polymer incorporated notably affected MPUs properties. The obtained samples exhibited low bulk density, good flowability-, as well as stability-related parameters, which indicated their suitability for filling into capsules or sachets. Low density values implied that compressibility enhancing excipients may be required for MPUs incorporation in tablets. Samples containing EC and MA-EA were found suitable for compression, due to high compacts tensile strength. The obtained results indicate that SeDeM Expert System may extended from powder compressibility evaluation tool to framework facilitating powders/multiparticulate units processing.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach",
volume = "629",
doi = "10.1016/j.ijpharm.2022.122337"
}

Vasiljević, I., Turković, E., Piller, M., Mirković, M., Zimmer, A., Aleksić, I., Ibrić, S.,& Parojčić, J.. (2022). Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 629.
https://doi.org/10.1016/j.ijpharm.2022.122337

Vasiljević I, Turković E, Piller M, Mirković M, Zimmer A, Aleksić I, Ibrić S, Parojčić J. Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2022;629.
doi:10.1016/j.ijpharm.2022.122337 .

Vasiljević, Ivana, Turković, Erna, Piller, Michael, Mirković, Miljana, Zimmer, Andreas, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, "Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach" in International Journal of Pharmaceutics, 629 (2022),
https://doi.org/10.1016/j.ijpharm.2022.122337 . .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5317
AB  - Additive manufacturing represents an emerging shift in the
pharmaceutical research, due to the opportunity for dosage
form individualization to the patient’s needs. Selective laser
sintering (SLS) is a novel 3D printing technology recently
introduced as the drug preparation method (1). Its potential
in the different dosage forms preparation, mainly tablets,
e.g. orodispersible tablets, was described in the literature
(2). However, the attempts in 3D printing of
multiparticulate dosage forms are scarce (3) and no SLS
printed granules were described in the literature.
The aim of this work was to prepare granules by SLS
printing and investigate the effect of formulation factors
(polymer type, model drug and particle size) on the critical
quality attributes of the obtained granules. ...
C3  - 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands
T1  - An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5317
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "Additive manufacturing represents an emerging shift in the
pharmaceutical research, due to the opportunity for dosage
form individualization to the patient’s needs. Selective laser
sintering (SLS) is a novel 3D printing technology recently
introduced as the drug preparation method (1). Its potential
in the different dosage forms preparation, mainly tablets,
e.g. orodispersible tablets, was described in the literature
(2). However, the attempts in 3D printing of
multiparticulate dosage forms are scarce (3) and no SLS
printed granules were described in the literature.
The aim of this work was to prepare granules by SLS
printing and investigate the effect of formulation factors
(polymer type, model drug and particle size) on the critical
quality attributes of the obtained granules. ...",
journal = "13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands",
title = "An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5317"
}

Vasiljević, I., Turković, E., Aleksić, I., Ibrić, S.,& Parojčić, J.. (2022). An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering. in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands.
https://hdl.handle.net/21.15107/rcub_farfar_5317

Vasiljević I, Turković E, Aleksić I, Ibrić S, Parojčić J. An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering. in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands. 2022;.
https://hdl.handle.net/21.15107/rcub_farfar_5317 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Ibrić, Svetlana, Parojčić, Jelena, "An investigation into the effect of formulation factors on the critical quality attributes of granules prepared by selective laser sintering" in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 28 - 31 March 2022, Rotterdam, The Netherlands (2022),
https://hdl.handle.net/21.15107/rcub_farfar_5317 .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Vasiljević, Dragana
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4758
AB  - 1. INTRODUCTION
Orodispersible films (ODF) have emerged as innovative dosage forms that provide wide variety of advantages for patients and manufacturers over conventional dosage forms. The prominent characteristic of ODFs is fast disintegration followed by good patients acceptability [1]. Therefore, relevant disintegration time (DT) is usually considered as ODF critical quality attribute. Extensive research on ODFs is generating a lot of data, but lack of standardization is the main obstacle that limits their comparative evaluation. The following work aims to explore literature data on ODFs characteristics using the predictive data-classification algorithm Support vector machine (SVM) and assess its applicability in pharmaceutical development based on the set of experimentally obtained data.
2. MATERIALS AND METHODS
2.1. Materials
Hydroxypropyl cellulose (Klucel GF, Ashland, USA), ethanol (≥99.8%, Honeywell, Charlotte, NC, USA) and glycerol, 85% (w/w) (Ph. Eur.) were used for preparation of printing and casting dispersion.
2.2. Data pre-processing
Comprehensive data exploration has been conducted in the PubMed database using most common synonyms for ODFs with fifteen synonyms in singular and plural. Built database had following attributes: manufacturing approach, polymer selection, polymer molecular weight (KDa), polymer load (%), mechanical properties (tensile strength (MPa), Young's modulus (MPa), elongation at break (%)), disintegration method and disintegration time (DT) (s).
2.3. ODF preparation and characterisation
Polymer dispersions for solvent casting and semi-solid extrusion 3D printing were prepared by dispersing HPC in ethanol:glicerol solution followed by continuous stirring on the magnetic stirrer. Prepared dispersions were: (i) casted on a unit-dose plexiglas plates, or (ii) printed using Ultimaker 2+ (Ultimaker, , Netherlands). ODFs were characterized in terms of mechanical properties using Z-LX Table-Top Testing Machine (Shimadzu, Japan) and DT using adapted compendial tester (Erweka ZT52, Germany) with a weight.
3. RESULTS AND DISCUSSION
3.1. Data pre-processing
274 papers (without reviews) were identified via search, of which 112 were included in the database. Nominal data from literature was transformed into numerical, using coding operator so that each nominal data had corresponding numerical value. Critical attributes for films fast disintegration were derived. 18 polymers were included as categorical data and were further differentiated on the basis of molecular weight. Values for most commonly evaluated mechanical properties were included as numerical data. Different DT methods were classified in seven classes (Table 1), while the manufacturing methods were classified in five classes. RapidMiner Studio 9.10 (RapidMiner, Dortmund, Germany) was used to transform data and employ SMV algorithm.
3.2. SVM model prediction
Attributes with the highest weight were polymer load and DT method employed (Figure 1). The polymer type and characteristic did have conclusive effects on DT as their weight varied during data mining. This can be attributed to inconclusive data provided in papers and lot of missing values for those attributes. Mechanical properties had low weight, which can be explained with the broad value range for those attributes. Different research groups had different approach to disintegration testing, which lowered model precision as it was reported that SVM does not have high accuracy when data is imbalanced [3]. Relative error value was 20%, which can be considered as high, but, having in mind great diversity in presented data and methodology, obtained value is still acceptable for the pilot study.
3.3. Experimental validation
HPC-based films prepared by 3D printing had tensile strength, elongation at break and Young’s modulus of 3.5 MPa, 137% and 5 MPa, respectively. Average DT was 69 s. For casted films, relevant values were 3.4 MPa, 105% and 3 MPa, and DT was 27 s. Experimentally obtained results were entered into model simulator (Figure 2) to simulate situation reflecting the experimental set up in which HPC-based films were prepared by 3D printing and solvent casting, and relevant attribute values obtained by samples characterization. In the case were manufacturing method was set to be 3D printing (coded as 1) predicted DT value was close to experimentally obtained value, i.e. 71.7 and 69 s, respectively. When solvent casting method was considered, predicted DT value was remarkedly higher than the experimentally obtained one, indicating bad predictability. It might be assumed that good predictability obtained in the case of 3D printed films is associated with lower data variability due to more simple sample composition and robust preparation method. In the case of casted films, data was much more complex due to a higher number of research papers and approaches to characterisation.
4. CONCLUSION
The obtained results indicate that SVM algorithm can be employed to predict ODF DT value based on the dataset created using literature data. However, in order to obtain meaningful predictions, larger dataset, with fewer inconsistences and less missing values would be advantageous.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - Application of support vector machine learning for orodispersible films disintegration time prediction
SP  - 239
EP  - 240
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4758
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Vasiljević, Dragana and Ibrić, Svetlana and Parojčić, Jelena",
year = "2022",
abstract = "1. INTRODUCTION
Orodispersible films (ODF) have emerged as innovative dosage forms that provide wide variety of advantages for patients and manufacturers over conventional dosage forms. The prominent characteristic of ODFs is fast disintegration followed by good patients acceptability [1]. Therefore, relevant disintegration time (DT) is usually considered as ODF critical quality attribute. Extensive research on ODFs is generating a lot of data, but lack of standardization is the main obstacle that limits their comparative evaluation. The following work aims to explore literature data on ODFs characteristics using the predictive data-classification algorithm Support vector machine (SVM) and assess its applicability in pharmaceutical development based on the set of experimentally obtained data.
2. MATERIALS AND METHODS
2.1. Materials
Hydroxypropyl cellulose (Klucel GF, Ashland, USA), ethanol (≥99.8%, Honeywell, Charlotte, NC, USA) and glycerol, 85% (w/w) (Ph. Eur.) were used for preparation of printing and casting dispersion.
2.2. Data pre-processing
Comprehensive data exploration has been conducted in the PubMed database using most common synonyms for ODFs with fifteen synonyms in singular and plural. Built database had following attributes: manufacturing approach, polymer selection, polymer molecular weight (KDa), polymer load (%), mechanical properties (tensile strength (MPa), Young's modulus (MPa), elongation at break (%)), disintegration method and disintegration time (DT) (s).
2.3. ODF preparation and characterisation
Polymer dispersions for solvent casting and semi-solid extrusion 3D printing were prepared by dispersing HPC in ethanol:glicerol solution followed by continuous stirring on the magnetic stirrer. Prepared dispersions were: (i) casted on a unit-dose plexiglas plates, or (ii) printed using Ultimaker 2+ (Ultimaker, , Netherlands). ODFs were characterized in terms of mechanical properties using Z-LX Table-Top Testing Machine (Shimadzu, Japan) and DT using adapted compendial tester (Erweka ZT52, Germany) with a weight.
3. RESULTS AND DISCUSSION
3.1. Data pre-processing
274 papers (without reviews) were identified via search, of which 112 were included in the database. Nominal data from literature was transformed into numerical, using coding operator so that each nominal data had corresponding numerical value. Critical attributes for films fast disintegration were derived. 18 polymers were included as categorical data and were further differentiated on the basis of molecular weight. Values for most commonly evaluated mechanical properties were included as numerical data. Different DT methods were classified in seven classes (Table 1), while the manufacturing methods were classified in five classes. RapidMiner Studio 9.10 (RapidMiner, Dortmund, Germany) was used to transform data and employ SMV algorithm.
3.2. SVM model prediction
Attributes with the highest weight were polymer load and DT method employed (Figure 1). The polymer type and characteristic did have conclusive effects on DT as their weight varied during data mining. This can be attributed to inconclusive data provided in papers and lot of missing values for those attributes. Mechanical properties had low weight, which can be explained with the broad value range for those attributes. Different research groups had different approach to disintegration testing, which lowered model precision as it was reported that SVM does not have high accuracy when data is imbalanced [3]. Relative error value was 20%, which can be considered as high, but, having in mind great diversity in presented data and methodology, obtained value is still acceptable for the pilot study.
3.3. Experimental validation
HPC-based films prepared by 3D printing had tensile strength, elongation at break and Young’s modulus of 3.5 MPa, 137% and 5 MPa, respectively. Average DT was 69 s. For casted films, relevant values were 3.4 MPa, 105% and 3 MPa, and DT was 27 s. Experimentally obtained results were entered into model simulator (Figure 2) to simulate situation reflecting the experimental set up in which HPC-based films were prepared by 3D printing and solvent casting, and relevant attribute values obtained by samples characterization. In the case were manufacturing method was set to be 3D printing (coded as 1) predicted DT value was close to experimentally obtained value, i.e. 71.7 and 69 s, respectively. When solvent casting method was considered, predicted DT value was remarkedly higher than the experimentally obtained one, indicating bad predictability. It might be assumed that good predictability obtained in the case of 3D printed films is associated with lower data variability due to more simple sample composition and robust preparation method. In the case of casted films, data was much more complex due to a higher number of research papers and approaches to characterisation.
4. CONCLUSION
The obtained results indicate that SVM algorithm can be employed to predict ODF DT value based on the dataset created using literature data. However, in order to obtain meaningful predictions, larger dataset, with fewer inconsistences and less missing values would be advantageous.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "Application of support vector machine learning for orodispersible films disintegration time prediction",
pages = "239-240",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4758"
}

Turković, E., Vasiljević, I., Vasiljević, D., Ibrić, S.,& Parojčić, J.. (2022). Application of support vector machine learning for orodispersible films disintegration time prediction. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 239-240.
https://hdl.handle.net/21.15107/rcub_farfar_4758

Turković E, Vasiljević I, Vasiljević D, Ibrić S, Parojčić J. Application of support vector machine learning for orodispersible films disintegration time prediction. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:239-240.
https://hdl.handle.net/21.15107/rcub_farfar_4758 .

Turković, Erna, Vasiljević, Ivana, Vasiljević, Dragana, Ibrić, Svetlana, Parojčić, Jelena, "Application of support vector machine learning for orodispersible films disintegration time prediction" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):239-240,
https://hdl.handle.net/21.15107/rcub_farfar_4758 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4760
AB  - 1. INTRODUCTION
Selective laser sintering (SLS) represents novel 3D printing technology recently introduced in drug fabrication. It is applicable in different dosage forms preparation, including multiparticulate units (MPUs) (1). The characteristics of the obtained MPUs remain to be described, particularly their compression behaviour and mechanical properties of the obtained compacts. The aim of this work was to investigate compaction suitability of MPUs prepared by SLS printing and investigate the effect of model drug type, polymer type and MPU size as well as compression pressure on the compression related parameters (detachment and ejection stress, nett work of compression) and the obtained compacts characteristics (out-of-die elastic recovery, solid fraction and tensile strength).
2. MATERIALS AND METHODS
2.1. Materials
The MPUs were prepared using either ethyl cellulose (EC, Ethocel, Fluka, Switzerland) or methacrylic acid-ethyl acrylate copolymer (1:1) (MA-EA, Eudragit L 100-55, Evonik, Germany) as polymer forming matrices. Ibuprofen (IBU) and caffeine (CAF) were used as model drugs and Candurin® Gold Sheen (CGS, Merck KGaA, Germany) was added as pharmaceutical grade colorant.
2.2. Multiparticulate units preparation
Spherical 3D models were designed and imported as print job file (.stec) to desktop SLS printer Sintratec Kit (Sintratec AG, Switzerland). Samples composition is presented in Table 1 (C-samples contain CAF, while I samples contain IBU).
2.3. Multiparticulate units compression
MPU compacts (100 mg) were prepared on an instrumented tablet press GTP series D (Gamlen Tableting Ltd, UK) in the single compression mode, under the compression loads of 250 and 500 kg, using 6 mm diameter flat punch, at the compaction speed 30 mm/min. The supporting software enabled complete visualization of the upper punch position and force in real time. The measured forcedisplacement curves were used to calculate net work of compression, friction force between lower punch and tablet during detachment phase (detachment stress) and friction force between die and tablet in the ejection phase (ejection stress). Compact dimensions were determined 24 hours after compression. Caliper was used to measure the out-of-die compact thickness (t), while compact diameter (R) and hardness (F) were measured using the hardness tester Erweka TBH 125D (Erweka GmbH, Germany). The obtained values were used to calculate compact tensile strength, solid fraction and out-of-die elastic recovery. In order to statistically investigate the input parameter effects (polymer type, model drug type and MPU size), experimental design was applied, using software Design-Expert v.7.0 (Stat-Ease Inc, USA).
3. RESULTS AND DISCUSSION
3.1. Multiparticulate units compression
The prepared compact tensile strength was generally higher than 1 MPa and acceptable (2), as represented in Fig. 1, while solid fraction ranged from 67.67 (C4) to 89.46% (C1 and I1). MPUs containing CAF and MPUs with MA-EA exhibited higher increase in solid fraction and tensile strength when compression load was increased, in comparison to samples prepared with IBU or EC, respectively. This indicates better tabletability and compressibility. MPU samples with MA-EA or 1 mm size exhibited higher nett work of compression, but also higher values of elastic recovery. Higher energy input corresponds to higher compressibility and susceptibility to particle consolidation. Ejection stress values did not exceed 3 MPa, which is associated with compact defect propensity (3), while detachment stress was lower than 4 MPa. This indicates that the prepared samples do not stick to punch and die and may be easily detached. All of the investigated factors (model drug type, polymer type, MPU size and compression pressure), as well as model drug-polymer type and model drug-compression pressure interaction significantly affected compact tensile strength (p<0.0001). In the case of MPUs containing CAF as model drug and EC as polymer, higher compression pressure increased tensile strength more notably. In the case of detachment stress, model drug type, polymer type and compression pressure were found as relevant factors (p=0.0013), while ejection stress was affected by polymer type, compression pressure and their interaction (p=0.0097). Elastic recovery was impacted by all the investigated parameters, as well as model drug type-polymer type and model drug type compression pressure interaction (p<0.0001). Higher compression pressure increased the elastic recovery values more notably in the case of IBU or EC samples. Model drug type, polymer type and compression pressure affected nett work (p<0.001), as well as model drug-compression pressure and polymer typecompression pressure interaction. Based on the investigated MPU samples, software-aided prediction recognized IBU, MA-EA and 1 mm-MPUs size as desirable for obtaining compacts with high tensile strength, but also low elastic recovery, low detachment and ejection stress and high nett work values.
4. CONCLUSION
The multiparticulate units were successfully compressed into compacts with good tensile strength values (higher than 1 MPa, generally), low detachment and ejection stress (lower than 3 and 4 MPa, respectively). MPUs containing CAF and MPUs with MA-EA exhibited higher tabletability and compressibility in comparison to samples prepared with IBU or EC, respectively. Polymer type and compression pressure affected all the investigated compact characteristics (tensile strength, detachment and ejection stress, out-of-die elastic recovery and nett work of compression), while MPU size impact on the observed parameters was the lowest. MPUs containing IBU and MA-EA, with 1 mm size were recognized as preferable for obtaining compacts with favourable characteristics.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - How formulation parameters affect compression behaviour of multiparticulate units prepared by selective laser sintering?
SP  - 249
EP  - 250
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4760
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena",
year = "2022",
abstract = "1. INTRODUCTION
Selective laser sintering (SLS) represents novel 3D printing technology recently introduced in drug fabrication. It is applicable in different dosage forms preparation, including multiparticulate units (MPUs) (1). The characteristics of the obtained MPUs remain to be described, particularly their compression behaviour and mechanical properties of the obtained compacts. The aim of this work was to investigate compaction suitability of MPUs prepared by SLS printing and investigate the effect of model drug type, polymer type and MPU size as well as compression pressure on the compression related parameters (detachment and ejection stress, nett work of compression) and the obtained compacts characteristics (out-of-die elastic recovery, solid fraction and tensile strength).
2. MATERIALS AND METHODS
2.1. Materials
The MPUs were prepared using either ethyl cellulose (EC, Ethocel, Fluka, Switzerland) or methacrylic acid-ethyl acrylate copolymer (1:1) (MA-EA, Eudragit L 100-55, Evonik, Germany) as polymer forming matrices. Ibuprofen (IBU) and caffeine (CAF) were used as model drugs and Candurin® Gold Sheen (CGS, Merck KGaA, Germany) was added as pharmaceutical grade colorant.
2.2. Multiparticulate units preparation
Spherical 3D models were designed and imported as print job file (.stec) to desktop SLS printer Sintratec Kit (Sintratec AG, Switzerland). Samples composition is presented in Table 1 (C-samples contain CAF, while I samples contain IBU).
2.3. Multiparticulate units compression
MPU compacts (100 mg) were prepared on an instrumented tablet press GTP series D (Gamlen Tableting Ltd, UK) in the single compression mode, under the compression loads of 250 and 500 kg, using 6 mm diameter flat punch, at the compaction speed 30 mm/min. The supporting software enabled complete visualization of the upper punch position and force in real time. The measured forcedisplacement curves were used to calculate net work of compression, friction force between lower punch and tablet during detachment phase (detachment stress) and friction force between die and tablet in the ejection phase (ejection stress). Compact dimensions were determined 24 hours after compression. Caliper was used to measure the out-of-die compact thickness (t), while compact diameter (R) and hardness (F) were measured using the hardness tester Erweka TBH 125D (Erweka GmbH, Germany). The obtained values were used to calculate compact tensile strength, solid fraction and out-of-die elastic recovery. In order to statistically investigate the input parameter effects (polymer type, model drug type and MPU size), experimental design was applied, using software Design-Expert v.7.0 (Stat-Ease Inc, USA).
3. RESULTS AND DISCUSSION
3.1. Multiparticulate units compression
The prepared compact tensile strength was generally higher than 1 MPa and acceptable (2), as represented in Fig. 1, while solid fraction ranged from 67.67 (C4) to 89.46% (C1 and I1). MPUs containing CAF and MPUs with MA-EA exhibited higher increase in solid fraction and tensile strength when compression load was increased, in comparison to samples prepared with IBU or EC, respectively. This indicates better tabletability and compressibility. MPU samples with MA-EA or 1 mm size exhibited higher nett work of compression, but also higher values of elastic recovery. Higher energy input corresponds to higher compressibility and susceptibility to particle consolidation. Ejection stress values did not exceed 3 MPa, which is associated with compact defect propensity (3), while detachment stress was lower than 4 MPa. This indicates that the prepared samples do not stick to punch and die and may be easily detached. All of the investigated factors (model drug type, polymer type, MPU size and compression pressure), as well as model drug-polymer type and model drug-compression pressure interaction significantly affected compact tensile strength (p<0.0001). In the case of MPUs containing CAF as model drug and EC as polymer, higher compression pressure increased tensile strength more notably. In the case of detachment stress, model drug type, polymer type and compression pressure were found as relevant factors (p=0.0013), while ejection stress was affected by polymer type, compression pressure and their interaction (p=0.0097). Elastic recovery was impacted by all the investigated parameters, as well as model drug type-polymer type and model drug type compression pressure interaction (p<0.0001). Higher compression pressure increased the elastic recovery values more notably in the case of IBU or EC samples. Model drug type, polymer type and compression pressure affected nett work (p<0.001), as well as model drug-compression pressure and polymer typecompression pressure interaction. Based on the investigated MPU samples, software-aided prediction recognized IBU, MA-EA and 1 mm-MPUs size as desirable for obtaining compacts with high tensile strength, but also low elastic recovery, low detachment and ejection stress and high nett work values.
4. CONCLUSION
The multiparticulate units were successfully compressed into compacts with good tensile strength values (higher than 1 MPa, generally), low detachment and ejection stress (lower than 3 and 4 MPa, respectively). MPUs containing CAF and MPUs with MA-EA exhibited higher tabletability and compressibility in comparison to samples prepared with IBU or EC, respectively. Polymer type and compression pressure affected all the investigated compact characteristics (tensile strength, detachment and ejection stress, out-of-die elastic recovery and nett work of compression), while MPU size impact on the observed parameters was the lowest. MPUs containing IBU and MA-EA, with 1 mm size were recognized as preferable for obtaining compacts with favourable characteristics.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "How formulation parameters affect compression behaviour of multiparticulate units prepared by selective laser sintering?",
pages = "249-250",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4760"
}

Vasiljević, I., Turković, E.,& Parojčić, J.. (2022). How formulation parameters affect compression behaviour of multiparticulate units prepared by selective laser sintering?. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 249-250.
https://hdl.handle.net/21.15107/rcub_farfar_4760

Vasiljević I, Turković E, Parojčić J. How formulation parameters affect compression behaviour of multiparticulate units prepared by selective laser sintering?. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:249-250.
https://hdl.handle.net/21.15107/rcub_farfar_4760 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, "How formulation parameters affect compression behaviour of multiparticulate units prepared by selective laser sintering?" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):249-250,
https://hdl.handle.net/21.15107/rcub_farfar_4760 .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4409
AB  - An understanding of material properties and processing effects on solid dosage forms
performance is required within the Quality-by-design approach to pharmaceutical development.
Several research groups have developed mathematical approaches aiming to facilitate the
selection of formulation composition and the manufacturing technology. These approaches are
based on material particulate, bulk and compression-related properties. This paper provides
theoretical assumptions and a critical review of different mathematical approaches for
processability characterization of powders and multiparticulate units.
Mathematical approaches have mainly been developed for directly compressible materials,
but sometimes other manufacturing technologies, such as roller compaction and wet granulation,
are also considered. The obtained compact tensile strength has been implemented in the majority
of approaches, as an important characteristic describing compact mechanical properties.
Flowability should be also evaluated, since it affects sample processability. Additionally, particle
size and shape, material density and compressibility, compactibility and tabletability profiles have
been also distinguished as relevant properties for solid dosage form development.
The application of mathematical approaches may contribute to the mechanistic
understanding of critical material attributes and facilitate dosage form development and
optimization. However, it is essential to select the appropriate one, based on the intended dosage
form characteristics, in order to ensure that all relevant powder/multiparticulate units
characteristics are implemented and critically evaluated.
AB  - Poznavanje uticaja svojstava materijala i procesnih parametara na karakteristike čvrstih farmaceutskih oblika predstavlja osnovu Quality-by-design pristupa razvoju lekova. Kako bi bio olakšan razvoj formulacije i izbor proizvodne tehnologije, više istraživačkih grupa opisalo je matematičke pristupe, koji se zasnivaju na čestičnim karakteristikama čestica, osobinama praška i ponašanju materijala pri kompresiji. U ovom radu prikazana su teorijska razmatranja i kritički pregled matematičkih pristupa razvijenih za karakterizaciju praškova i višečestičnih sistema. Ovi matematički pristupi su, generalno, razvijeni za karakterizaciju materijala pogodnih za direktnu kompresiju. Međutim, u nekim slučajevima se razmatraju i druge tehnologije, kao što su suva i vlažna granulacija. Među opisanim karakteristikama materijala, zatezna čvrstina se izdvaja kao jedna od najznačajnijih za procenu mehaničkih svojstava kompakta. Potrebno je ispitati i protočnost materijala. Takođe, veličina i oblik čestica, gustina materijala i profili koji opisuju kompresibilnost, kompaktibilnost i tabletabilnost materijala prepoznati su kao karakteristike koje značajno utiču na razvoj čvrstih farmaceutskih oblika. Primena matematičkih pristupa u karakterizaciji praškova i višečestičnih sistema može doprineti mehanističkom razumevanju svojstava materijala i olakšati razvoj i optimizaciju čvrstih farmaceutskih oblika lekova. Međutim, ključno je odabrati odgovarajući pristup, zavisno od željenih karakteristika finalnog preparata, kako bi sva kritična svojstva materijala bila ispitana i kritički razmotrena.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development
T1  - Pregled i kritička analiza matematičkih pristupa za karakterizaciju praškova i višečestičnih sistema u razvoju lekova
VL  - 72
IS  - 6
SP  - 637
EP  - 660
DO  - 10.5937/arhfarm72-40961
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Parojčić, Jelena",
year = "2022",
abstract = "An understanding of material properties and processing effects on solid dosage forms
performance is required within the Quality-by-design approach to pharmaceutical development.
Several research groups have developed mathematical approaches aiming to facilitate the
selection of formulation composition and the manufacturing technology. These approaches are
based on material particulate, bulk and compression-related properties. This paper provides
theoretical assumptions and a critical review of different mathematical approaches for
processability characterization of powders and multiparticulate units.
Mathematical approaches have mainly been developed for directly compressible materials,
but sometimes other manufacturing technologies, such as roller compaction and wet granulation,
are also considered. The obtained compact tensile strength has been implemented in the majority
of approaches, as an important characteristic describing compact mechanical properties.
Flowability should be also evaluated, since it affects sample processability. Additionally, particle
size and shape, material density and compressibility, compactibility and tabletability profiles have
been also distinguished as relevant properties for solid dosage form development.
The application of mathematical approaches may contribute to the mechanistic
understanding of critical material attributes and facilitate dosage form development and
optimization. However, it is essential to select the appropriate one, based on the intended dosage
form characteristics, in order to ensure that all relevant powder/multiparticulate units
characteristics are implemented and critically evaluated., Poznavanje uticaja svojstava materijala i procesnih parametara na karakteristike čvrstih farmaceutskih oblika predstavlja osnovu Quality-by-design pristupa razvoju lekova. Kako bi bio olakšan razvoj formulacije i izbor proizvodne tehnologije, više istraživačkih grupa opisalo je matematičke pristupe, koji se zasnivaju na čestičnim karakteristikama čestica, osobinama praška i ponašanju materijala pri kompresiji. U ovom radu prikazana su teorijska razmatranja i kritički pregled matematičkih pristupa razvijenih za karakterizaciju praškova i višečestičnih sistema. Ovi matematički pristupi su, generalno, razvijeni za karakterizaciju materijala pogodnih za direktnu kompresiju. Međutim, u nekim slučajevima se razmatraju i druge tehnologije, kao što su suva i vlažna granulacija. Među opisanim karakteristikama materijala, zatezna čvrstina se izdvaja kao jedna od najznačajnijih za procenu mehaničkih svojstava kompakta. Potrebno je ispitati i protočnost materijala. Takođe, veličina i oblik čestica, gustina materijala i profili koji opisuju kompresibilnost, kompaktibilnost i tabletabilnost materijala prepoznati su kao karakteristike koje značajno utiču na razvoj čvrstih farmaceutskih oblika. Primena matematičkih pristupa u karakterizaciji praškova i višečestičnih sistema može doprineti mehanističkom razumevanju svojstava materijala i olakšati razvoj i optimizaciju čvrstih farmaceutskih oblika lekova. Međutim, ključno je odabrati odgovarajući pristup, zavisno od željenih karakteristika finalnog preparata, kako bi sva kritična svojstva materijala bila ispitana i kritički razmotrena.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development, Pregled i kritička analiza matematičkih pristupa za karakterizaciju praškova i višečestičnih sistema u razvoju lekova",
volume = "72",
number = "6",
pages = "637-660",
doi = "10.5937/arhfarm72-40961"
}

Vasiljević, I., Turković, E., Aleksić, I.,& Parojčić, J.. (2022). Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 637-660.
https://doi.org/10.5937/arhfarm72-40961

Vasiljević I, Turković E, Aleksić I, Parojčić J. Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development. in Arhiv za farmaciju. 2022;72(6):637-660.
doi:10.5937/arhfarm72-40961 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Parojčić, Jelena, "Mathematical approaches for powders and multiparticulate units processability characterization in pharmaceutical development" in Arhiv za farmaciju, 72, no. 6 (2022):637-660,
https://doi.org/10.5937/arhfarm72-40961 . .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4575
AB  - Thin films are relatively new drug forms, which contain one or more active
substances, dispersed or adsorbed on a polymeric carrier (1). The aim of this work was to
evaluate the effects of the preparation and formulation factors on film critical quality
attributes. Films were prepared by solvent-casting and 3D printing of dispersion on a
Ultimaker 2+. Dispersion consisted of hydroxypropylcellulose with or without the addition
of sodium-alginate. Caffeine and ibuprofen were used as model drugs. The films were
characterized in terms of mass, thickness, moisture content (LJ16-Moisture Analizer) and
mechanical characteristics (EZ-LKS-Table-TopMachine). Obtained results indicate that 3D
films had higher mass and thickness compared to casted films, except for
hydroxypropylcellulose/sodium alginate/caffeine sample (37.6 and 59.0 mg/cm2 ; 526 and
642 μm). High content of dispersed substances can cause a change in polymer drying
behavior, which is reflected in film characteristics. Dissolving ibuprofen in the initial
dispersion, led to film increased elasticity and decreased tensile strength, negatively
affecting handling and stickiness of the films prepared by either method. Differences
between methods were most pronounced in films with dispersed caffeine or sodium-
alginate. Sodium-alginate generally decreased, and caffeine increased flexibility. The
preparation process did not affect the moisture content in samples, although the polymer
drying differed between two preparation methods. Increased moisture content was
generally accompanied by decreased flexibility, except for samples with ibuprofen. Obtained
results indicate significant effects of the formulation process and composition on the film
characteristics. Dissolved or dispersed substance content in formulation should be adapted
to the chosen preparation method.
AB  - Tanki oralni filmovi predstavljaju noviji farmaceutski oblik leka, koji sadrži jednu ili
više aktivnih supstanci dispergovanih ili adsorbovanih na polimernom nosaču (1). Cilj ovog
rada bio je ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva
kvaliteta filmova. Filmovi su izrađivani izlivanjem disperzije u kalupe ili metodom 3D štampe
(Ultimaker 2+). Disperzija se sastojala od hidroksipropilceluloze, sa ili bez dodatka natrijum-
alginata. Model aktivne supstance bile su kofein i ibuprofen. Karakterizacija filmova
obuhvatila je određivanje mase, debljine, udela vlage (LJ16-MoistureAnalyzer) i mehaničkih
karakteristika (EZ-LX-Table-TopMachine). Dobijeni rezultati su pokazali da su 3D štampani
filmovi imali veću masu i debljinu u odnosu na izlivene filmove, osim u slučaju uzorka
hidroksipropilceluloza/natrijum-alginat/kofein (37,6 i 59,0 mg/cm 2; 526 i 642 μm). Visok
udeo dispergovanih supstanci u uzorku može uzrokovati promenu u ponašanju polimera
prilikom sušenja što se odražava na karakteristike filmova. Rastvaranje ibuprofena dovelo je
do povećanja elastičnosti i smanjenja zatezne čvrstine filmova u slučaju oba postupka izrade,
što je imalo negativan efekat na lakoću rukovanja i lepljivost. Postupak izrade imao je najveći
uticaj na karakteristike filmova sa natrijum-alginatom i filmova koji su sadržali kofein.
Natrijum-alginat je generalno smanjivao, a kofein povećavao fleksibilnost filmova. Postupak
izrade nije imao uticaj na udeo vlage, iako je sušenje filmova bilo značajno različito kod ova
dva postupka. Povećanje udela vlage uglavnom je pratilo smanjenje fleksibilnosti filmova,
osim kod uzoraka sa ibuprofenom. Dobijeni rezultati ukazuju na značajan uticaj postupka
izrade i sastava formulacije na karakteristike tankih filmova. Udeo rastvorenih ili
dispergovanih supstanci u formulaciji moraju biti prilagođeni odabranom postupku izrade.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into the effects of preparation methods and composition on thin film critical quality attributes
T1  - Ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva kvaliteta tankih oralnih filmova
VL  - 72
IS  - 4 suplement
SP  - S422
EP  - S423
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4575
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Vasiljević, Dragana and Parojčić, Jelena",
year = "2022",
abstract = "Thin films are relatively new drug forms, which contain one or more active
substances, dispersed or adsorbed on a polymeric carrier (1). The aim of this work was to
evaluate the effects of the preparation and formulation factors on film critical quality
attributes. Films were prepared by solvent-casting and 3D printing of dispersion on a
Ultimaker 2+. Dispersion consisted of hydroxypropylcellulose with or without the addition
of sodium-alginate. Caffeine and ibuprofen were used as model drugs. The films were
characterized in terms of mass, thickness, moisture content (LJ16-Moisture Analizer) and
mechanical characteristics (EZ-LKS-Table-TopMachine). Obtained results indicate that 3D
films had higher mass and thickness compared to casted films, except for
hydroxypropylcellulose/sodium alginate/caffeine sample (37.6 and 59.0 mg/cm2 ; 526 and
642 μm). High content of dispersed substances can cause a change in polymer drying
behavior, which is reflected in film characteristics. Dissolving ibuprofen in the initial
dispersion, led to film increased elasticity and decreased tensile strength, negatively
affecting handling and stickiness of the films prepared by either method. Differences
between methods were most pronounced in films with dispersed caffeine or sodium-
alginate. Sodium-alginate generally decreased, and caffeine increased flexibility. The
preparation process did not affect the moisture content in samples, although the polymer
drying differed between two preparation methods. Increased moisture content was
generally accompanied by decreased flexibility, except for samples with ibuprofen. Obtained
results indicate significant effects of the formulation process and composition on the film
characteristics. Dissolved or dispersed substance content in formulation should be adapted
to the chosen preparation method., Tanki oralni filmovi predstavljaju noviji farmaceutski oblik leka, koji sadrži jednu ili
više aktivnih supstanci dispergovanih ili adsorbovanih na polimernom nosaču (1). Cilj ovog
rada bio je ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva
kvaliteta filmova. Filmovi su izrađivani izlivanjem disperzije u kalupe ili metodom 3D štampe
(Ultimaker 2+). Disperzija se sastojala od hidroksipropilceluloze, sa ili bez dodatka natrijum-
alginata. Model aktivne supstance bile su kofein i ibuprofen. Karakterizacija filmova
obuhvatila je određivanje mase, debljine, udela vlage (LJ16-MoistureAnalyzer) i mehaničkih
karakteristika (EZ-LX-Table-TopMachine). Dobijeni rezultati su pokazali da su 3D štampani
filmovi imali veću masu i debljinu u odnosu na izlivene filmove, osim u slučaju uzorka
hidroksipropilceluloza/natrijum-alginat/kofein (37,6 i 59,0 mg/cm 2; 526 i 642 μm). Visok
udeo dispergovanih supstanci u uzorku može uzrokovati promenu u ponašanju polimera
prilikom sušenja što se odražava na karakteristike filmova. Rastvaranje ibuprofena dovelo je
do povećanja elastičnosti i smanjenja zatezne čvrstine filmova u slučaju oba postupka izrade,
što je imalo negativan efekat na lakoću rukovanja i lepljivost. Postupak izrade imao je najveći
uticaj na karakteristike filmova sa natrijum-alginatom i filmova koji su sadržali kofein.
Natrijum-alginat je generalno smanjivao, a kofein povećavao fleksibilnost filmova. Postupak
izrade nije imao uticaj na udeo vlage, iako je sušenje filmova bilo značajno različito kod ova
dva postupka. Povećanje udela vlage uglavnom je pratilo smanjenje fleksibilnosti filmova,
osim kod uzoraka sa ibuprofenom. Dobijeni rezultati ukazuju na značajan uticaj postupka
izrade i sastava formulacije na karakteristike tankih filmova. Udeo rastvorenih ili
dispergovanih supstanci u formulaciji moraju biti prilagođeni odabranom postupku izrade.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into the effects of preparation methods and composition on thin film critical quality attributes, Ispitivanje uticaja postupka izrade i faktora formulacije na kritična svojstva kvaliteta tankih oralnih filmova",
volume = "72",
number = "4 suplement",
pages = "S422-S423",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4575"
}

Turković, E., Vasiljević, I., Vasiljević, D.,& Parojčić, J.. (2022). An investigation into the effects of preparation methods and composition on thin film critical quality attributes. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S422-S423.
https://hdl.handle.net/21.15107/rcub_farfar_4575

Turković E, Vasiljević I, Vasiljević D, Parojčić J. An investigation into the effects of preparation methods and composition on thin film critical quality attributes. in Arhiv za farmaciju. 2022;72(4 suplement):S422-S423.
https://hdl.handle.net/21.15107/rcub_farfar_4575 .

Turković, Erna, Vasiljević, Ivana, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into the effects of preparation methods and composition on thin film critical quality attributes" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S422-S423,
https://hdl.handle.net/21.15107/rcub_farfar_4575 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Parojčić, Jelena
AU  - Vasiljević, Dragana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4521
AB  - The estimated prevalence of swallowing problems and dysphagia is 22%, particularly
among pediatric and geriatric population. The drug administration for these individuals is
challenging and efforts are being made to enhance solid dosage forms swallowing. The aim of
this work was to characterize inulin-based puddings as potential vehicula for solid dosage
forms administration. Three marketed instant puddings were prepared according to
instructions provided by the manufacturer (mixing with the appropriate amount of cold
milk, without cooking) and characterized regarding pH value, rheological characteristics and
textural properties (hardness and adhesiveness). The investigated samples differed in terms
of inulin content, as gelling agent (3.3-8%), and aroma (vanilla, chocolate, coco). Generally,
samples exhibited comparable characteristics. pH values of prepared puddings ranged from
6.57 to 6.90. Apparent viscosity values, measured at 50 s -1 , were 4850-16800 mPas,
indicating that puddings belong to class 4 (extremely thick drinks), according to
International Dysphagia Diet Standardization Initiative Framework (1), suitable for patients
suffering from advanced dysphagia. Samples’ hardness values ranged from 54.6 mN (coco
pudding) to 63.9 mN (chocolate pudding), whereas adhesiveness ranged from 30.26 gs (coco
pudding) to 40.64 gs (chocolate pudding), indicating the soft structure and swallowing
suitability, without the need for intense chewing (2). The investigated puddings exhibited
suitable characteristics in terms of viscosity and textural properties for patients with
advanced dysphagia and represent promising approach as vehicula for solid dosage forms
administration in the case of this population.
AB  - Procenjuje se da oko 22% stanovništva ima probleme sa gutanjem i disfagijom, pri
čemu je problem naročito izražen u pedijatrijskoj i gerijatrijskoj populaciji. Primena lekova
kod ovih osoba je otežana i potrebno je razviti odgovarajuće pristupe koji olakšavaju gutanje
čvrstih farmaceutskih oblika. Cilj ovog rada bio je karakterizacija komercijalno dostupnih
instant pudinga, kao potencijalnih vehikuluma za primenu čvrstih farmaceutskih oblika
lekova. Tri komercijalno dostupna instant pudinga su pripremljena prema uputstvu
proizvođača (mešanje sa propisanom zapreminom hladnog mleka, bez kuvanja) i
okarakterisana u pogledu pH vrednosti, reoloških karakteristika i teksture (čvrstina i
adhezivnost). Sastav ispitivanih uzoraka se razlikovao u pogledu udela inulina kao sredstva
za geliranje (3,3-8%) i arome (vanila, čokolada, kokos). Generalno, svojstva ispitivanih
proizvoda bila su uporediva. pH vrednost pripremljenih pudinga bila je 6,57-6,90. Svi uzorci
pokazali su tiksotropno ponašanje. Vrednosti prividnog viskoziteta, izmerene na 50 s -1 , bile
su 4850-16800 mPas, ukazujući da pudinzi spadaju u klasu 4 (veoma guste tečnosti) prema
Smernicama Inicijative za međunarodnu standardizaciju ishrane u disfagiji (1) i da su pogodni
za pacijente sa uznapredovalom disfagijom. Čvrstina uzoraka bila je u rasponu od 54,6 mN
(puding od kokosa) do 63,9 mN (puding od čokolade), a adhezivnost od 30,26 gs (puding od
kokosa) do 40,64 gs (puding od čokolade), ukazujući na meku strukturu i pogodnost za
gutanje bez intenzivnog žvakanja (2). Ispitivani pudinzi pokazali su pogodni viskozitet i
teksturu za primenu kod pacijenata sa uznapredovalom disfagijom i predstavljaju
obećavajući pristup za primenu čvrstih farmaceutskih oblika kod ove populacije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia
T1  - Ispitivanje instant pudinga kao potencijalnih vehikuluma za primenu lekova kod pacijenata sa disfagijom
VL  - 72
IS  - 4 suplement
SP  - S237
EP  - S238
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4521
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Parojčić, Jelena and Vasiljević, Dragana",
year = "2022",
abstract = "The estimated prevalence of swallowing problems and dysphagia is 22%, particularly
among pediatric and geriatric population. The drug administration for these individuals is
challenging and efforts are being made to enhance solid dosage forms swallowing. The aim of
this work was to characterize inulin-based puddings as potential vehicula for solid dosage
forms administration. Three marketed instant puddings were prepared according to
instructions provided by the manufacturer (mixing with the appropriate amount of cold
milk, without cooking) and characterized regarding pH value, rheological characteristics and
textural properties (hardness and adhesiveness). The investigated samples differed in terms
of inulin content, as gelling agent (3.3-8%), and aroma (vanilla, chocolate, coco). Generally,
samples exhibited comparable characteristics. pH values of prepared puddings ranged from
6.57 to 6.90. Apparent viscosity values, measured at 50 s -1 , were 4850-16800 mPas,
indicating that puddings belong to class 4 (extremely thick drinks), according to
International Dysphagia Diet Standardization Initiative Framework (1), suitable for patients
suffering from advanced dysphagia. Samples’ hardness values ranged from 54.6 mN (coco
pudding) to 63.9 mN (chocolate pudding), whereas adhesiveness ranged from 30.26 gs (coco
pudding) to 40.64 gs (chocolate pudding), indicating the soft structure and swallowing
suitability, without the need for intense chewing (2). The investigated puddings exhibited
suitable characteristics in terms of viscosity and textural properties for patients with
advanced dysphagia and represent promising approach as vehicula for solid dosage forms
administration in the case of this population., Procenjuje se da oko 22% stanovništva ima probleme sa gutanjem i disfagijom, pri
čemu je problem naročito izražen u pedijatrijskoj i gerijatrijskoj populaciji. Primena lekova
kod ovih osoba je otežana i potrebno je razviti odgovarajuće pristupe koji olakšavaju gutanje
čvrstih farmaceutskih oblika. Cilj ovog rada bio je karakterizacija komercijalno dostupnih
instant pudinga, kao potencijalnih vehikuluma za primenu čvrstih farmaceutskih oblika
lekova. Tri komercijalno dostupna instant pudinga su pripremljena prema uputstvu
proizvođača (mešanje sa propisanom zapreminom hladnog mleka, bez kuvanja) i
okarakterisana u pogledu pH vrednosti, reoloških karakteristika i teksture (čvrstina i
adhezivnost). Sastav ispitivanih uzoraka se razlikovao u pogledu udela inulina kao sredstva
za geliranje (3,3-8%) i arome (vanila, čokolada, kokos). Generalno, svojstva ispitivanih
proizvoda bila su uporediva. pH vrednost pripremljenih pudinga bila je 6,57-6,90. Svi uzorci
pokazali su tiksotropno ponašanje. Vrednosti prividnog viskoziteta, izmerene na 50 s -1 , bile
su 4850-16800 mPas, ukazujući da pudinzi spadaju u klasu 4 (veoma guste tečnosti) prema
Smernicama Inicijative za međunarodnu standardizaciju ishrane u disfagiji (1) i da su pogodni
za pacijente sa uznapredovalom disfagijom. Čvrstina uzoraka bila je u rasponu od 54,6 mN
(puding od kokosa) do 63,9 mN (puding od čokolade), a adhezivnost od 30,26 gs (puding od
kokosa) do 40,64 gs (puding od čokolade), ukazujući na meku strukturu i pogodnost za
gutanje bez intenzivnog žvakanja (2). Ispitivani pudinzi pokazali su pogodni viskozitet i
teksturu za primenu kod pacijenata sa uznapredovalom disfagijom i predstavljaju
obećavajući pristup za primenu čvrstih farmaceutskih oblika kod ove populacije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia, Ispitivanje instant pudinga kao potencijalnih vehikuluma za primenu lekova kod pacijenata sa disfagijom",
volume = "72",
number = "4 suplement",
pages = "S237-S238",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4521"
}

Vasiljević, I., Turković, E., Parojčić, J.,& Vasiljević, D.. (2022). An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S237-S238.
https://hdl.handle.net/21.15107/rcub_farfar_4521

Vasiljević I, Turković E, Parojčić J, Vasiljević D. An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia. in Arhiv za farmaciju. 2022;72(4 suplement):S237-S238.
https://hdl.handle.net/21.15107/rcub_farfar_4521 .

Vasiljević, Ivana, Turković, Erna, Parojčić, Jelena, Vasiljević, Dragana, "An investigation into instant puddings as potential vehicula for drug administration in patients with dysphagia" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S237-S238,
https://hdl.handle.net/21.15107/rcub_farfar_4521 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Aleksić, Ivana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5526
AB  - Introduction: Expert System for Drug Development (SeDeM) was introduced as a method intended for powder processability assessment (1). Its applicability was extended to multiparticulate materials (2-3), but the contribution to liquisolid admixtures/pellets characterization remains to be explored. The aim of this work was to investigate the applicability of SeDeM on liquisolid admixtures/pellets. Methods: Liquisolid admixtures (A) were prepared by manual kneading and subsequently extruded/spheronized into liquisolid pellets (P). ...
C3  - Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting
T1  - Investigation into applicability of Expert System for Drug Development on the model liquisolid systems
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5526
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and Aleksić, Ivana and Parojčić, Jelena",
year = "2021",
abstract = "Introduction: Expert System for Drug Development (SeDeM) was introduced as a method intended for powder processability assessment (1). Its applicability was extended to multiparticulate materials (2-3), but the contribution to liquisolid admixtures/pellets characterization remains to be explored. The aim of this work was to investigate the applicability of SeDeM on liquisolid admixtures/pellets. Methods: Liquisolid admixtures (A) were prepared by manual kneading and subsequently extruded/spheronized into liquisolid pellets (P). ...",
journal = "Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting",
title = "Investigation into applicability of Expert System for Drug Development on the model liquisolid systems",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5526"
}

Vasiljević, I., Turković, E., Aleksić, I.,& Parojčić, J.. (2021). Investigation into applicability of Expert System for Drug Development on the model liquisolid systems. in Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting.
https://hdl.handle.net/21.15107/rcub_farfar_5526

Vasiljević I, Turković E, Aleksić I, Parojčić J. Investigation into applicability of Expert System for Drug Development on the model liquisolid systems. in Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_5526 .

Vasiljević, Ivana, Turković, Erna, Aleksić, Ivana, Parojčić, Jelena, "Investigation into applicability of Expert System for Drug Development on the model liquisolid systems" in Controlled Release Society: “Breakthrough Delivery Science”, 2021 July 25-29, Virtual Annual Meeting (2021),
https://hdl.handle.net/21.15107/rcub_farfar_5526 .

TY  - CONF
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - German Ilić, Ilija
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5315
AB  - Software assisted image analysis represents emerging approach, which may provide useful insight
into sample properties [1]. However, its application in the pharmaceutical field is scarce. The aim of
this work was to investigate the applicability of software assisted porosity evaluation in liquisolid
pellets characterization. ...
PB  - Medical University of Gdansk
PB  - Polskie Towarzystwo Farmaceutyczne
C3  - Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
T1  - Applicability of software assisted porosity evaluation in liquisolid pellets characterization
SP  - 75
EP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5315
ER  - 

@conference{
author = "Vasiljević, Ivana and Turković, Erna and German Ilić, Ilija and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Software assisted image analysis represents emerging approach, which may provide useful insight
into sample properties [1]. However, its application in the pharmaceutical field is scarce. The aim of
this work was to investigate the applicability of software assisted porosity evaluation in liquisolid
pellets characterization. ...",
publisher = "Medical University of Gdansk, Polskie Towarzystwo Farmaceutyczne",
journal = "Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland",
title = "Applicability of software assisted porosity evaluation in liquisolid pellets characterization",
pages = "75-75",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5315"
}

Vasiljević, I., Turković, E., German Ilić, I., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Applicability of software assisted porosity evaluation in liquisolid pellets characterization. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland
Medical University of Gdansk., 75-75.
https://hdl.handle.net/21.15107/rcub_farfar_5315

Vasiljević I, Turković E, German Ilić I, Zimmer A, Parojčić J, Aleksić I. Applicability of software assisted porosity evaluation in liquisolid pellets characterization. in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland. 2021;:75-75.
https://hdl.handle.net/21.15107/rcub_farfar_5315 .

Vasiljević, Ivana, Turković, Erna, German Ilić, Ilija, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Applicability of software assisted porosity evaluation in liquisolid pellets characterization" in Proceedings CESPT 2021: 13th Central European Symposium on Pharmaceutical Technology: Contemporary pharmaceutical technology - addressing challenges of innovative and generic medicinal products, 16th-18th September 2021, Gdansk, Poland (2021):75-75,
https://hdl.handle.net/21.15107/rcub_farfar_5315 .

TY  - CONF
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4670
AB  - Growing demands for environmental sustainability and responsible exploitation of
natural resources has led to increased research on the potential use and reprocessing of
different waste materials as primary source of starting materials for different industries.
Rigorous quality requirements for pharmaceutical active and auxiliary substances is
hindering wider use of reprocessed waste materials in pharmaceutical industry. However,
certain advances have been recently introduced in the field of natural polymers
(biopolymers) production (1).
Biocompatible, biodegradable and, generally, non-toxic biopolymers offer numerous
advantages in different drug delivery systems development. In this review, focus is on
biopolymers used as potential film-forming agents (FFA) for pharmaceutical oral films. An
overview of the most commonly used biopolymers produced from different waste materials,
resources used, and their application in pharmaceutical oral films manufacture is
schematically presented in Figure 1.
AB  - Održiva životna sredina i odgovorno korišćenje prirodnih resursa postali su značajan
zadatak za moderno društvo, što je dovelo do povećanja aktivnosti na polju istraživanja o
mogućnosti korišćenja i obradi različitih otpadnih materijala kao primarnog izvora polaznih
supstanci za različite grane industrije. Rigorozni zahtevi za kvalitet aktivnih i pomoćnih
supstanci ograničavaju širu upotrebu prerađenih materijala u farmaceutskoj industriji. Ipak,
određeni pomaci postoje na polju dobijanja prirodnih polimera (biopolimera) (1).
Biokompatibilni, biorazgradivi i netoksični biopolimeri nude brojne prednosti. Ovaj pregled
usmeren je na biopolimere koji potencijalno mogu da se koriste kao sredstva za formiranje
filma prilikom razvoja oralnih filmova kao farmaceutskog oblika leka. Pregled najčešće
korišćenih biopolimera koji se proizvode iz različitih otpadnih materijala, korišćeni izvori za
proizvodnju i njihova primena u izradi farmaceutskih oralnih filmova je shematski prikazana
na Slici 1.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review
T1  - Pregled polimera za izradu farmaceutskih oralnih filmova dobijenih preradom različitih otpadnih materijala
VL  - 71
IS  - 5 suplement
SP  - S76
EP  - S79
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4670
ER  - 

@conference{
author = "Turković, Erna and Vasiljević, Ivana and Parojčić, Jelena",
year = "2021",
abstract = "Growing demands for environmental sustainability and responsible exploitation of
natural resources has led to increased research on the potential use and reprocessing of
different waste materials as primary source of starting materials for different industries.
Rigorous quality requirements for pharmaceutical active and auxiliary substances is
hindering wider use of reprocessed waste materials in pharmaceutical industry. However,
certain advances have been recently introduced in the field of natural polymers
(biopolymers) production (1).
Biocompatible, biodegradable and, generally, non-toxic biopolymers offer numerous
advantages in different drug delivery systems development. In this review, focus is on
biopolymers used as potential film-forming agents (FFA) for pharmaceutical oral films. An
overview of the most commonly used biopolymers produced from different waste materials,
resources used, and their application in pharmaceutical oral films manufacture is
schematically presented in Figure 1., Održiva životna sredina i odgovorno korišćenje prirodnih resursa postali su značajan
zadatak za moderno društvo, što je dovelo do povećanja aktivnosti na polju istraživanja o
mogućnosti korišćenja i obradi različitih otpadnih materijala kao primarnog izvora polaznih
supstanci za različite grane industrije. Rigorozni zahtevi za kvalitet aktivnih i pomoćnih
supstanci ograničavaju širu upotrebu prerađenih materijala u farmaceutskoj industriji. Ipak,
određeni pomaci postoje na polju dobijanja prirodnih polimera (biopolimera) (1).
Biokompatibilni, biorazgradivi i netoksični biopolimeri nude brojne prednosti. Ovaj pregled
usmeren je na biopolimere koji potencijalno mogu da se koriste kao sredstva za formiranje
filma prilikom razvoja oralnih filmova kao farmaceutskog oblika leka. Pregled najčešće
korišćenih biopolimera koji se proizvode iz različitih otpadnih materijala, korišćeni izvori za
proizvodnju i njihova primena u izradi farmaceutskih oralnih filmova je shematski prikazana
na Slici 1.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review, Pregled polimera za izradu farmaceutskih oralnih filmova dobijenih preradom različitih otpadnih materijala",
volume = "71",
number = "5 suplement",
pages = "S76-S79",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4670"
}

Turković, E., Vasiljević, I.,& Parojčić, J.. (2021). Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S76-S79.
https://hdl.handle.net/21.15107/rcub_farfar_4670

Turković E, Vasiljević I, Parojčić J. Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review. in Arhiv za farmaciju. 2021;71(5 suplement):S76-S79.
https://hdl.handle.net/21.15107/rcub_farfar_4670 .

Turković, Erna, Vasiljević, Ivana, Parojčić, Jelena, "Reprocessing waste materials to produce film‐forming polymers for pharmaceutical oral films – review" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S76-S79,
https://hdl.handle.net/21.15107/rcub_farfar_4670 .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Nenadović, Snežana
AU  - Mirković, Miljana
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3921
AB  - Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Investigation into liquisolid system processability based on the SeDeM Expert System approach
VL  - 605
DO  - 10.1016/j.ijpharm.2021.120847
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Nenadović, Snežana and Mirković, Miljana and Zimmer, Andreas and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Investigation into liquisolid system processability based on the SeDeM Expert System approach",
volume = "605",
doi = "10.1016/j.ijpharm.2021.120847"
}

Vasiljević, I., Turković, E., Nenadović, S., Mirković, M., Zimmer, A., Parojčić, J.,& Aleksić, I.. (2021). Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics
Elsevier B.V.., 605.
https://doi.org/10.1016/j.ijpharm.2021.120847

Vasiljević I, Turković E, Nenadović S, Mirković M, Zimmer A, Parojčić J, Aleksić I. Investigation into liquisolid system processability based on the SeDeM Expert System approach. in International Journal of Pharmaceutics. 2021;605.
doi:10.1016/j.ijpharm.2021.120847 .

Vasiljević, Ivana, Turković, Erna, Nenadović, Snežana, Mirković, Miljana, Zimmer, Andreas, Parojčić, Jelena, Aleksić, Ivana, "Investigation into liquisolid system processability based on the SeDeM Expert System approach" in International Journal of Pharmaceutics, 605 (2021),
https://doi.org/10.1016/j.ijpharm.2021.120847 . .

TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Obradović, Nataša
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3819
AB  - Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.
PB  - MDPI
T2  - Pharmaceutics
T1  - An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
VL  - 13
IS  - 4
DO  - 10.3390/pharmaceutics13040468
ER  - 

@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Obradović, Nataša and Vasiljević, Dragana and Parojčić, Jelena",
year = "2021",
abstract = "Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films",
volume = "13",
number = "4",
doi = "10.3390/pharmaceutics13040468"
}

Turković, E., Vasiljević, I., Drašković, M., Obradović, N., Vasiljević, D.,& Parojčić, J.. (2021). An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics
MDPI., 13(4).
https://doi.org/10.3390/pharmaceutics13040468

Turković E, Vasiljević I, Drašković M, Obradović N, Vasiljević D, Parojčić J. An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics. 2021;13(4).
doi:10.3390/pharmaceutics13040468 .

Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Obradović, Nataša, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films" in Pharmaceutics, 13, no. 4 (2021),
https://doi.org/10.3390/pharmaceutics13040468 . .

TY  - JOUR
AU  - Vasiljević, Ivana
AU  - Turković, Erna
AU  - Piller, Michael
AU  - Zimmer, Andreas
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3763
AB  - Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.
PB  - Elsevier B.V.
T2  - Powder Technology
T1  - An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization
VL  - 379
SP  - 526
EP  - 536
DO  - 10.1016/j.powtec.2020.10.085
ER  - 

@article{
author = "Vasiljević, Ivana and Turković, Erna and Piller, Michael and Zimmer, Andreas and Parojčić, Jelena",
year = "2021",
abstract = "Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.",
publisher = "Elsevier B.V.",
journal = "Powder Technology",
title = "An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization",
volume = "379",
pages = "526-536",
doi = "10.1016/j.powtec.2020.10.085"
}

Vasiljević, I., Turković, E., Piller, M., Zimmer, A.,& Parojčić, J.. (2021). An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization. in Powder Technology
Elsevier B.V.., 379, 526-536.
https://doi.org/10.1016/j.powtec.2020.10.085

Vasiljević I, Turković E, Piller M, Zimmer A, Parojčić J. An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization. in Powder Technology. 2021;379:526-536.
doi:10.1016/j.powtec.2020.10.085 .

Vasiljević, Ivana, Turković, Erna, Piller, Michael, Zimmer, Andreas, Parojčić, Jelena, "An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization" in Powder Technology, 379 (2021):526-536,
https://doi.org/10.1016/j.powtec.2020.10.085 . .