TY  - JOUR
AU  - Sopić, Miron
AU  - Karaduzovic-Hadziabdic, Kanita
AU  - Kardassis, Dimitris
AU  - Maegdefessel, Lars
AU  - Martelli, Fabio
AU  - Meerson, Ari
AU  - Munjas, Jelena
AU  - Niculescu, Loredan S.
AU  - Stoll, Monika
AU  - Magni, Paolo
AU  - Devaux, Yvan
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5616
AB  - Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research.
PB  - Elsevier Ltd.
T2  - Journal of Molecular and Cellular Cardiology Plus
T1  - Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges
VL  - 6
SP  - 100048
DO  - 10.1016/j.jmccpl.2023.100048
ER  - 

@article{
author = "Sopić, Miron and Karaduzovic-Hadziabdic, Kanita and Kardassis, Dimitris and Maegdefessel, Lars and Martelli, Fabio and Meerson, Ari and Munjas, Jelena and Niculescu, Loredan S. and Stoll, Monika and Magni, Paolo and Devaux, Yvan",
year = "2023",
abstract = "Atherosclerotic disease is a major cause of acute cardiovascular events. A deeper understanding of its underlying mechanisms will allow advancing personalized and patient-centered healthcare. Transcriptomic research has proven to be a powerful tool for unravelling the complex molecular pathways that drive atherosclerosis. However, low reproducibility of research findings and lack of standardization of procedures pose significant challenges in this field. In this review, we discuss how transcriptomic research can help in understanding the different phenotypes of the atherosclerotic plaque that contribute to the development and progression of atherosclerosis. We highlight the methodological challenges that need to be addressed to improve research outputs, and emphasize the importance of research protocols harmonization. We also discuss recent advances in transcriptomic research, including bulk or single-cell sequencing, and their added value in plaque phenotyping. Finally, we explore how integrated multiomics data and machine learning improve understanding of atherosclerosis and provide directions for future research.",
publisher = "Elsevier Ltd.",
journal = "Journal of Molecular and Cellular Cardiology Plus",
title = "Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges",
volume = "6",
pages = "100048",
doi = "10.1016/j.jmccpl.2023.100048"
}

Sopić, M., Karaduzovic-Hadziabdic, K., Kardassis, D., Maegdefessel, L., Martelli, F., Meerson, A., Munjas, J., Niculescu, L. S., Stoll, M., Magni, P.,& Devaux, Y.. (2023). Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges. in Journal of Molecular and Cellular Cardiology Plus
Elsevier Ltd.., 6, 100048.
https://doi.org/10.1016/j.jmccpl.2023.100048

Sopić M, Karaduzovic-Hadziabdic K, Kardassis D, Maegdefessel L, Martelli F, Meerson A, Munjas J, Niculescu LS, Stoll M, Magni P, Devaux Y. Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges. in Journal of Molecular and Cellular Cardiology Plus. 2023;6:100048.
doi:10.1016/j.jmccpl.2023.100048 .

Sopić, Miron, Karaduzovic-Hadziabdic, Kanita, Kardassis, Dimitris, Maegdefessel, Lars, Martelli, Fabio, Meerson, Ari, Munjas, Jelena, Niculescu, Loredan S., Stoll, Monika, Magni, Paolo, Devaux, Yvan, "Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges" in Journal of Molecular and Cellular Cardiology Plus, 6 (2023):100048,
https://doi.org/10.1016/j.jmccpl.2023.100048 . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Robinson, Emma L.
AU  - Emanueli, Costanza
AU  - Srivastava, Prashant
AU  - Angione, Claudio
AU  - Gaetano, Carlo
AU  - Condorelli, Gianluigi
AU  - Martelli, Fabio
AU  - Pedrazzini, Thierry
AU  - Devaux, Yvan
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4746
AB  - The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Basic Research in Cardiology
T1  - Integration of epigenetic regulatory mechanisms in heart failure
VL  - 118
IS  - 1
DO  - 10.1007/s00395-023-00986-3
ER  - 

@article{
author = "Sopić, Miron and Robinson, Emma L. and Emanueli, Costanza and Srivastava, Prashant and Angione, Claudio and Gaetano, Carlo and Condorelli, Gianluigi and Martelli, Fabio and Pedrazzini, Thierry and Devaux, Yvan",
year = "2023",
abstract = "The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Basic Research in Cardiology",
title = "Integration of epigenetic regulatory mechanisms in heart failure",
volume = "118",
number = "1",
doi = "10.1007/s00395-023-00986-3"
}

Sopić, M., Robinson, E. L., Emanueli, C., Srivastava, P., Angione, C., Gaetano, C., Condorelli, G., Martelli, F., Pedrazzini, T.,& Devaux, Y.. (2023). Integration of epigenetic regulatory mechanisms in heart failure. in Basic Research in Cardiology
Springer Science and Business Media Deutschland GmbH., 118(1).
https://doi.org/10.1007/s00395-023-00986-3

Sopić M, Robinson EL, Emanueli C, Srivastava P, Angione C, Gaetano C, Condorelli G, Martelli F, Pedrazzini T, Devaux Y. Integration of epigenetic regulatory mechanisms in heart failure. in Basic Research in Cardiology. 2023;118(1).
doi:10.1007/s00395-023-00986-3 .

Sopić, Miron, Robinson, Emma L., Emanueli, Costanza, Srivastava, Prashant, Angione, Claudio, Gaetano, Carlo, Condorelli, Gianluigi, Martelli, Fabio, Pedrazzini, Thierry, Devaux, Yvan, "Integration of epigenetic regulatory mechanisms in heart failure" in Basic Research in Cardiology, 118, no. 1 (2023),
https://doi.org/10.1007/s00395-023-00986-3 . .