TY  - JOUR
AU  - Sopić, Miron
AU  - Robinson, Emma L.
AU  - Emanueli, Costanza
AU  - Srivastava, Prashant
AU  - Angione, Claudio
AU  - Gaetano, Carlo
AU  - Condorelli, Gianluigi
AU  - Martelli, Fabio
AU  - Pedrazzini, Thierry
AU  - Devaux, Yvan
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4746
AB  - The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Basic Research in Cardiology
T1  - Integration of epigenetic regulatory mechanisms in heart failure
VL  - 118
IS  - 1
DO  - 10.1007/s00395-023-00986-3
ER  - 

@article{
author = "Sopić, Miron and Robinson, Emma L. and Emanueli, Costanza and Srivastava, Prashant and Angione, Claudio and Gaetano, Carlo and Condorelli, Gianluigi and Martelli, Fabio and Pedrazzini, Thierry and Devaux, Yvan",
year = "2023",
abstract = "The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Basic Research in Cardiology",
title = "Integration of epigenetic regulatory mechanisms in heart failure",
volume = "118",
number = "1",
doi = "10.1007/s00395-023-00986-3"
}

Sopić, M., Robinson, E. L., Emanueli, C., Srivastava, P., Angione, C., Gaetano, C., Condorelli, G., Martelli, F., Pedrazzini, T.,& Devaux, Y.. (2023). Integration of epigenetic regulatory mechanisms in heart failure. in Basic Research in Cardiology
Springer Science and Business Media Deutschland GmbH., 118(1).
https://doi.org/10.1007/s00395-023-00986-3

Sopić M, Robinson EL, Emanueli C, Srivastava P, Angione C, Gaetano C, Condorelli G, Martelli F, Pedrazzini T, Devaux Y. Integration of epigenetic regulatory mechanisms in heart failure. in Basic Research in Cardiology. 2023;118(1).
doi:10.1007/s00395-023-00986-3 .

Sopić, Miron, Robinson, Emma L., Emanueli, Costanza, Srivastava, Prashant, Angione, Claudio, Gaetano, Carlo, Condorelli, Gianluigi, Martelli, Fabio, Pedrazzini, Thierry, Devaux, Yvan, "Integration of epigenetic regulatory mechanisms in heart failure" in Basic Research in Cardiology, 118, no. 1 (2023),
https://doi.org/10.1007/s00395-023-00986-3 . .