TY  - JOUR
AU  - Stojanova, Monika
AU  - Pantić, Milena
AU  - Klaus, Anita
AU  - Mihajlović, Dragana
AU  - Miletić, Dunja
AU  - Šobajić, Slađana
AU  - Stojanova, M.T.
AU  - Nikšić, Miomir
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4690
AB  - The aim of this research was to produce a lyophilised water and ethanol extract from Fuscoporia torulosa mushroom, to determine the antimicrobial and antioxidant potential of the extracts and in industrial conditions to produce a new, functional product – Bio Soups, enriched with lyophilised extracts derived from fruiting body of F. torulosa mushroom, at the same time without use of synthetic additives. The application of the lyophilised extracts in the industrial production of dehydrated soups showed positive results. Such soups are characterised with higher (P < 0.05) antimicrobial and antioxidant activity, compared to conventional soups, while it has been proven constant biological potential and stability up to the 90th day of production. This is the first dehydrated soup enriched with lyophilised extract of medicinal mushroom, since its production does not require special conditions, and it possesses exceptional functional properties, this product could have a many times greater market potential compared to conventional soups
PB  - John Wiley and Sons Inc
T2  - International Journal of Food Science and Technology
T1  - Bio soups – new functional dehydrated soups enriched with lyophilised Fuscoporia torulosa extracts
VL  - 58
IS  - 7
SP  - 3628
EP  - 3636
DO  - 10.1111/ijfs.16462
ER  - 

@article{
author = "Stojanova, Monika and Pantić, Milena and Klaus, Anita and Mihajlović, Dragana and Miletić, Dunja and Šobajić, Slađana and Stojanova, M.T. and Nikšić, Miomir",
year = "2023",
abstract = "The aim of this research was to produce a lyophilised water and ethanol extract from Fuscoporia torulosa mushroom, to determine the antimicrobial and antioxidant potential of the extracts and in industrial conditions to produce a new, functional product – Bio Soups, enriched with lyophilised extracts derived from fruiting body of F. torulosa mushroom, at the same time without use of synthetic additives. The application of the lyophilised extracts in the industrial production of dehydrated soups showed positive results. Such soups are characterised with higher (P < 0.05) antimicrobial and antioxidant activity, compared to conventional soups, while it has been proven constant biological potential and stability up to the 90th day of production. This is the first dehydrated soup enriched with lyophilised extract of medicinal mushroom, since its production does not require special conditions, and it possesses exceptional functional properties, this product could have a many times greater market potential compared to conventional soups",
publisher = "John Wiley and Sons Inc",
journal = "International Journal of Food Science and Technology",
title = "Bio soups – new functional dehydrated soups enriched with lyophilised Fuscoporia torulosa extracts",
volume = "58",
number = "7",
pages = "3628-3636",
doi = "10.1111/ijfs.16462"
}

Stojanova, M., Pantić, M., Klaus, A., Mihajlović, D., Miletić, D., Šobajić, S., Stojanova, M.T.,& Nikšić, M.. (2023). Bio soups – new functional dehydrated soups enriched with lyophilised Fuscoporia torulosa extracts. in International Journal of Food Science and Technology
John Wiley and Sons Inc., 58(7), 3628-3636.
https://doi.org/10.1111/ijfs.16462

Stojanova M, Pantić M, Klaus A, Mihajlović D, Miletić D, Šobajić S, Stojanova M, Nikšić M. Bio soups – new functional dehydrated soups enriched with lyophilised Fuscoporia torulosa extracts. in International Journal of Food Science and Technology. 2023;58(7):3628-3636.
doi:10.1111/ijfs.16462 .

Stojanova, Monika, Pantić, Milena, Klaus, Anita, Mihajlović, Dragana, Miletić, Dunja, Šobajić, Slađana, Stojanova, M.T., Nikšić, Miomir, "Bio soups – new functional dehydrated soups enriched with lyophilised Fuscoporia torulosa extracts" in International Journal of Food Science and Technology, 58, no. 7 (2023):3628-3636,
https://doi.org/10.1111/ijfs.16462 . .

TY  - JOUR
AU  - Jovanović-Macura, Irena
AU  - Đuričić, Ivana
AU  - Major, Tamara
AU  - Milanović, Desanka
AU  - Šobajić, Slađana
AU  - Kanazir, Selma
AU  - Ivković, Sanja
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5543
AB  - Introduction: During fetal development, the proper development of neural and visual systems relies on the maternal supplementation of omega-3 fatty acids through placental transfer. Pregnant women are strongly advised to augment their diet with additional sources of omega-3, such as fish oil (FO). This supplementation has been linked to a reduced risk of preterm birth, pre-eclampsia, and perinatal depression. Recently, higher doses of omega-3 supplementation have been recommended for pregnant women. Considering that omega-3 fatty acids, particularly docosahexaenoic acid (DHA), play a crucial role in maintaining the delicate homeostasis required for the proper functioning of the retina and photoreceptors the effects of high-dose fish oil (FO) supplementation during pregnancy and lactation on the retina and retinal pigmented epithelium (RPE) in healthy offspring warrant better understanding. Methods: The fatty acid content and the changes in the expression of the genes regulating cholesterol homeostasis and DHA transport in the retina and RPE were evaluated following the high-dose FO supplementation. Results: Our study demonstrated that despite the high-dose FO treatment during pregnancy and lactation, the rigorous DHA homeostasis in the retina and RPE of the two-month-old offspring remained balanced. Another significant finding of this study is the increase in the expression levels of major facilitator superfamily domain-containing protein (Mfsd2a), a primary DHA transporter. Mfsd2a also serves as a major regulator of transcytosis during development, and a reduction in Mfsd2a levels poses a major risk for the development of leaky blood vessels. Conclusion: Impairment of the blood-retinal barrier (BRB) is associated with the development of numerous ocular diseases, and a better understanding of how to manipulate transcytosis in the BRB during development can enhance drug delivery through the BRB or contribute to the repair of central nervous system (CNS) barriers.
PB  - Frontiers Media SA
T2  - Frontiers in Nutrition
T1  - The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring
VL  - 10
SP  - 1330414
DO  - 10.3389/fnut.2023.1330414
ER  - 

@article{
author = "Jovanović-Macura, Irena and Đuričić, Ivana and Major, Tamara and Milanović, Desanka and Šobajić, Slađana and Kanazir, Selma and Ivković, Sanja",
year = "2023",
abstract = "Introduction: During fetal development, the proper development of neural and visual systems relies on the maternal supplementation of omega-3 fatty acids through placental transfer. Pregnant women are strongly advised to augment their diet with additional sources of omega-3, such as fish oil (FO). This supplementation has been linked to a reduced risk of preterm birth, pre-eclampsia, and perinatal depression. Recently, higher doses of omega-3 supplementation have been recommended for pregnant women. Considering that omega-3 fatty acids, particularly docosahexaenoic acid (DHA), play a crucial role in maintaining the delicate homeostasis required for the proper functioning of the retina and photoreceptors the effects of high-dose fish oil (FO) supplementation during pregnancy and lactation on the retina and retinal pigmented epithelium (RPE) in healthy offspring warrant better understanding. Methods: The fatty acid content and the changes in the expression of the genes regulating cholesterol homeostasis and DHA transport in the retina and RPE were evaluated following the high-dose FO supplementation. Results: Our study demonstrated that despite the high-dose FO treatment during pregnancy and lactation, the rigorous DHA homeostasis in the retina and RPE of the two-month-old offspring remained balanced. Another significant finding of this study is the increase in the expression levels of major facilitator superfamily domain-containing protein (Mfsd2a), a primary DHA transporter. Mfsd2a also serves as a major regulator of transcytosis during development, and a reduction in Mfsd2a levels poses a major risk for the development of leaky blood vessels. Conclusion: Impairment of the blood-retinal barrier (BRB) is associated with the development of numerous ocular diseases, and a better understanding of how to manipulate transcytosis in the BRB during development can enhance drug delivery through the BRB or contribute to the repair of central nervous system (CNS) barriers.",
publisher = "Frontiers Media SA",
journal = "Frontiers in Nutrition",
title = "The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring",
volume = "10",
pages = "1330414",
doi = "10.3389/fnut.2023.1330414"
}

Jovanović-Macura, I., Đuričić, I., Major, T., Milanović, D., Šobajić, S., Kanazir, S.,& Ivković, S.. (2023). The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring. in Frontiers in Nutrition
Frontiers Media SA., 10, 1330414.
https://doi.org/10.3389/fnut.2023.1330414

Jovanović-Macura I, Đuričić I, Major T, Milanović D, Šobajić S, Kanazir S, Ivković S. The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring. in Frontiers in Nutrition. 2023;10:1330414.
doi:10.3389/fnut.2023.1330414 .

Jovanović-Macura, Irena, Đuričić, Ivana, Major, Tamara, Milanović, Desanka, Šobajić, Slađana, Kanazir, Selma, Ivković, Sanja, "The supplementation of a high dose of fish oil during pregnancy and lactation led to an elevation in Mfsd2a expression without any changes in docosahexaenoic acid levels in the retina of healthy 2-month-old mouse offspring" in Frontiers in Nutrition, 10 (2023):1330414,
https://doi.org/10.3389/fnut.2023.1330414 . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Božić, Dragana
AU  - Antić-Stanković, Jelena
AU  - Šobajić, Slađana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5140
AB  - Semenke predstavljaju najvredniji deo ploda vinove loze. Polifenolna jedinjenja se primarno
koncentrišu tamo, zbog čega semenke poseduju jaku antioksidativnu aktivnost. Zahvaljujući tome,
ekstrakti semenki mogu delovati kao antimikrobni agensi. Ekstrakcija bioaktivnih jedinjenja se
obično vrši pomoću isparljivih, organskih rastvarača. Poslednjih godina, zajedno sa povećanjem
svesti o značaju zaštite životne sredine, različiti „zeleni“ rastvarači su se pojavili kao alternativa
konvencionalnim.
Ova studija je imala za cilj ispitivanje razlika između semenki različitih sorti grožđa u pogledu
njihove antimikrobne aktivnosti prema Staphylococcus aureus. Takođe je procenjen afinitet
eutektičkog rastvarača za ekstrakciju polifenola iz semenki grožđa. Kao referentni rastvarač
korišćen je etanol.
Semenke su izolovane iz pet različitih sorti crvenog grožđa koje se široko gaje u Srbiji.
Ultrazvučna ekstrakcija izvedena je korišćenjem eutektičkog rastvarača (holin hlorid:limunska
kiselina, 2:1, 30 % vode; ChCit) i 70 % etanola. Ukupan sadržaj polifenola (eng. Total Phenolic
Content; TPC) je određen Folin-Ciocalteu metodom. Antimikrobna aktivnost uzoraka je ispitivana
je na standardnom soju Staphylococcus aureus ATCC 6538 bujon-mikrodilucionim testom.
TPC vrednosti su se kretale od 91,75 do 116,71 i od 84,79 do 135,5 mg GAE/g suve mase (za
ChCit i etanolne ekstrakte, respektivno). Semenke sorte Prokupac imale su najveći sadržaj ukupnih
polifenola, bez obzira na upotrebljeni rastvarač. Vrednosti minimalnih inhibitornih koncentracija
(MIK) su se kretale između 0,04 i 0,15 mg/ml. ChCit ekstrakti su bili slični ili čak efikasniji protiv
ove Gram-pozitivne bakterije u poređenju sa etanolnim ekstraktima. Ovo bi moglo biti delimično
objašnjeno antimikrobnom aktivnošću samog rastvarača, pošto je primećeno da ChCit inhibira rast
Staphylococcus aureus (MIK=0,3 mg/ml).
Imajući u vidu da su ekstrakti pokazali znatno jaču aktivnost u odnosu na rastvarač i da su
rezultati ispitivanja antimikrobne aktivnosti bili u značajnoj korelaciji sa sadržajem polifenola,
može se zaključiti da je sinergizam između prisutnih polifenola i ChCit rezultirao snažnom
antimikrobnom aktivnošću protiv Staphylococcus aureus u ekološki prihvatljivijim ekstraktima.
PB  - Srpsko udruženje za kliničku mikrobiologiju (SUKM)
C3  - SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata
T1  - Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa
SP  - 56
EP  - 56
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5140
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Božić, Dragana and Antić-Stanković, Jelena and Šobajić, Slađana",
year = "2023",
abstract = "Semenke predstavljaju najvredniji deo ploda vinove loze. Polifenolna jedinjenja se primarno
koncentrišu tamo, zbog čega semenke poseduju jaku antioksidativnu aktivnost. Zahvaljujući tome,
ekstrakti semenki mogu delovati kao antimikrobni agensi. Ekstrakcija bioaktivnih jedinjenja se
obično vrši pomoću isparljivih, organskih rastvarača. Poslednjih godina, zajedno sa povećanjem
svesti o značaju zaštite životne sredine, različiti „zeleni“ rastvarači su se pojavili kao alternativa
konvencionalnim.
Ova studija je imala za cilj ispitivanje razlika između semenki različitih sorti grožđa u pogledu
njihove antimikrobne aktivnosti prema Staphylococcus aureus. Takođe je procenjen afinitet
eutektičkog rastvarača za ekstrakciju polifenola iz semenki grožđa. Kao referentni rastvarač
korišćen je etanol.
Semenke su izolovane iz pet različitih sorti crvenog grožđa koje se široko gaje u Srbiji.
Ultrazvučna ekstrakcija izvedena je korišćenjem eutektičkog rastvarača (holin hlorid:limunska
kiselina, 2:1, 30 % vode; ChCit) i 70 % etanola. Ukupan sadržaj polifenola (eng. Total Phenolic
Content; TPC) je određen Folin-Ciocalteu metodom. Antimikrobna aktivnost uzoraka je ispitivana
je na standardnom soju Staphylococcus aureus ATCC 6538 bujon-mikrodilucionim testom.
TPC vrednosti su se kretale od 91,75 do 116,71 i od 84,79 do 135,5 mg GAE/g suve mase (za
ChCit i etanolne ekstrakte, respektivno). Semenke sorte Prokupac imale su najveći sadržaj ukupnih
polifenola, bez obzira na upotrebljeni rastvarač. Vrednosti minimalnih inhibitornih koncentracija
(MIK) su se kretale između 0,04 i 0,15 mg/ml. ChCit ekstrakti su bili slični ili čak efikasniji protiv
ove Gram-pozitivne bakterije u poređenju sa etanolnim ekstraktima. Ovo bi moglo biti delimično
objašnjeno antimikrobnom aktivnošću samog rastvarača, pošto je primećeno da ChCit inhibira rast
Staphylococcus aureus (MIK=0,3 mg/ml).
Imajući u vidu da su ekstrakti pokazali znatno jaču aktivnost u odnosu na rastvarač i da su
rezultati ispitivanja antimikrobne aktivnosti bili u značajnoj korelaciji sa sadržajem polifenola,
može se zaključiti da je sinergizam između prisutnih polifenola i ChCit rezultirao snažnom
antimikrobnom aktivnošću protiv Staphylococcus aureus u ekološki prihvatljivijim ekstraktima.",
publisher = "Srpsko udruženje za kliničku mikrobiologiju (SUKM)",
journal = "SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata",
title = "Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa",
pages = "56-56",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5140"
}

Dabetić, N., Todorović, V., Božić, D., Antić-Stanković, J.,& Šobajić, S.. (2023). Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa. in SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata
Srpsko udruženje za kliničku mikrobiologiju (SUKM)., 56-56.
https://hdl.handle.net/21.15107/rcub_farfar_5140

Dabetić N, Todorović V, Božić D, Antić-Stanković J, Šobajić S. Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa. in SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata. 2023;:56-56.
https://hdl.handle.net/21.15107/rcub_farfar_5140 .

Dabetić, Nevena, Todorović, Vanja, Božić, Dragana, Antić-Stanković, Jelena, Šobajić, Slađana, "Zelena ekstrakcija sa antimikrobnom aktivnošću protiv Staphylococcus aureus iz semenki grožđa" in SKKM 2023 -  1. srpski kongres kliničke mikrobiologije sa međunarodnim učešćem, 10-12 maj 2023, Beograd - Knjiga apstrakata (2023):56-56,
https://hdl.handle.net/21.15107/rcub_farfar_5140 .

TY  - JOUR
AU  - Jovanović Macura, Irena
AU  - Đuričić, Ivana
AU  - Major, Tamara
AU  - Milanović, Desanka
AU  - Brkić, Marjana
AU  - Šobajić, Slađana
AU  - Kanazir, Selma
AU  - Ivković, Sanja
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4309
AB  - The recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the exact effects of such FO supplementation on the healthy retina and retinal pigmented epithelium (RPE) are unknown. Our study showed that the high dose FO treatment did not imbalance the rigorous docosahexaenoic acid (DHA, C22:6n3) homeostasis in the retina and RPE in the three-month-old female B6/SLJ mice. Instead, we have found the significant increase in the expression of Mfsd2a, the main DHA transporter. Mfsd2a is also an essential regulator of blood vessel transcytosis and the decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels.
PB  - Elsevier Ltd
T2  - Journal of Functional Foods
T1  - The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice
VL  - 99
DO  - 10.1016/j.jff.2022.105302
ER  - 

@article{
author = "Jovanović Macura, Irena and Đuričić, Ivana and Major, Tamara and Milanović, Desanka and Brkić, Marjana and Šobajić, Slađana and Kanazir, Selma and Ivković, Sanja",
year = "2022",
abstract = "The recommended fish oil (FO) supplementation doses often yield low omega-3 polyunsaturated fatty acids (PUFAs) tissue bioavailability, and higher doses (up to 10 g per day) have been increasingly recommended. However, the exact effects of such FO supplementation on the healthy retina and retinal pigmented epithelium (RPE) are unknown. Our study showed that the high dose FO treatment did not imbalance the rigorous docosahexaenoic acid (DHA, C22:6n3) homeostasis in the retina and RPE in the three-month-old female B6/SLJ mice. Instead, we have found the significant increase in the expression of Mfsd2a, the main DHA transporter. Mfsd2a is also an essential regulator of blood vessel transcytosis and the decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels.",
publisher = "Elsevier Ltd",
journal = "Journal of Functional Foods",
title = "The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice",
volume = "99",
doi = "10.1016/j.jff.2022.105302"
}

Jovanović Macura, I., Đuričić, I., Major, T., Milanović, D., Brkić, M., Šobajić, S., Kanazir, S.,& Ivković, S.. (2022). The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice. in Journal of Functional Foods
Elsevier Ltd., 99.
https://doi.org/10.1016/j.jff.2022.105302

Jovanović Macura I, Đuričić I, Major T, Milanović D, Brkić M, Šobajić S, Kanazir S, Ivković S. The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice. in Journal of Functional Foods. 2022;99.
doi:10.1016/j.jff.2022.105302 .

Jovanović Macura, Irena, Đuričić, Ivana, Major, Tamara, Milanović, Desanka, Brkić, Marjana, Šobajić, Slađana, Kanazir, Selma, Ivković, Sanja, "The high-dose fish oil supplementation increased Mfsd2a expression without altering DHA levels in the retina of healthy mice" in Journal of Functional Foods, 99 (2022),
https://doi.org/10.1016/j.jff.2022.105302 . .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Zrnić-Ćirić, Milica
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4499
AB  - Wine industry generates enormous quantities of solid organic waste consisted of
stems, skins and seeds. Grape seeds are considered the most valuable part of a pomace, since
it is rich in oil and containing numerous bioactive compounds. Grape seed oil (GSO)
composition depends mainly on grape variety, but also on environmental factors and
maturation degree. The aim of this study was to investigate the diversity of chemical
composition among seed oils obtained from different grape varieties. Eight varieties were
collected from the same wine region and at the same maturity phase. Investigation of fatty
acid composition was done using GC/FID, while HPLC/FD was employed for vitamin E
analyses. Linoleic acid was the most abundant in all samples, followed by oleic acid.
Saturated fatty acids, such as palmitic and stearic acid, were also present (up to 20 % of the
total fatty acid methyl esters). Vitamin E concentrations were significantly affected by grape
variety (p<0.01). α-tocopherol was found in high concentration in all samples. GSO from
Shiraz variety had about 25 mg α-tocopherol per kg of oil, while Gamay GSO contained more
than six times less amounts of this vitamin E isoform. Sum of β and γ tocopherol also varied
considerable, although Shiraz again stood out with the highest content. Finally, δ tocopherol
was found in four varieties, in minor quantities. Generally, considering variety diversification
on vitamin E composition of GSO, investigations that will include as much varieties as
possible, are needed to single out ones with the highest bio-oil potential.
AB  - Industrija vina ostavlja za sobom ogromne količine čvrstog organskog otpada koji se
sastoji od peteljki, pokožice i semenki grožđa. Semenke se smatraju najvrednijim delom
komine, jer su bogate uljem i sadrže brojna bioaktivna jedinjenja. Sastav ulja iz semenki
grožđa zavisi pre svega od sorte vinove loze, ali i od faktora sredine i stepena zrelosti ploda.
Cilj ovog rada bilo je ispitivanje raznolikosti hemijskog sastava ulja dobijenog iz semenki
različitih sorti grožđa. U tu svrhu, prikupljeno je osam sorti u istoj fazi zrelosti i iz istog
vinskog regiona. Ispitivanje sastava masnih kiselina vršeno je korišćenjem GC/FID, dok je
HPLC/FD korišćen za analizu koncentracije vitamina E. Linolna kiselina je bila
najzastupljenija u svim uzorcima, zatim oleinska kiselina. Zasićene masne kiseline, kao što su
palmitinska i stearinska kiselina, takođe su bile prisutne (do 20 % od ukupnih metil estara
masnih kiselina). Sorta vinove loze je značajno uticala na sadržaj vitamina E (p<0,01). α-
tokoferol je pronađen u visokim koncentracijama u svim uzorcima. Ulje iz semenki sorte
Širaz sadržalo je oko 25 miligrama α-tokoferola po kilogramu, dok je u ulju sorte Game
kvantifikovana šest puta manja koncentracija ove izoforme vitamina E. Zbir β i γ tokoferola
takođe je značajno varirao, iako se Širaz ponovo istakao sa najvećim sadržajem. δ tokoferol je
pronađen u ulju četiri sorte, u manjim količinama. Generalno, s obzirom na raznovrsnost
sastava vitamina E u ulju iz semenki grožđa, potrebna su opsežnija istraživanja koja će
obuhvatiti veći broj sorti vinove loze kako bi se izdvojile one sa najvećim potencijalom bio-
ulja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Diversity of chemical composition among seed oils obtained from different grape varieties
T1  - Raznolikost hemijskog sastava ulja dobijenog iz semenki različitih sorti grožđa
VL  - 72
IS  - 4 suplement
SP  - S217
EP  - S218
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4499
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Zrnić-Ćirić, Milica and Đuričić, Ivana and Šobajić, Slađana",
year = "2022",
abstract = "Wine industry generates enormous quantities of solid organic waste consisted of
stems, skins and seeds. Grape seeds are considered the most valuable part of a pomace, since
it is rich in oil and containing numerous bioactive compounds. Grape seed oil (GSO)
composition depends mainly on grape variety, but also on environmental factors and
maturation degree. The aim of this study was to investigate the diversity of chemical
composition among seed oils obtained from different grape varieties. Eight varieties were
collected from the same wine region and at the same maturity phase. Investigation of fatty
acid composition was done using GC/FID, while HPLC/FD was employed for vitamin E
analyses. Linoleic acid was the most abundant in all samples, followed by oleic acid.
Saturated fatty acids, such as palmitic and stearic acid, were also present (up to 20 % of the
total fatty acid methyl esters). Vitamin E concentrations were significantly affected by grape
variety (p<0.01). α-tocopherol was found in high concentration in all samples. GSO from
Shiraz variety had about 25 mg α-tocopherol per kg of oil, while Gamay GSO contained more
than six times less amounts of this vitamin E isoform. Sum of β and γ tocopherol also varied
considerable, although Shiraz again stood out with the highest content. Finally, δ tocopherol
was found in four varieties, in minor quantities. Generally, considering variety diversification
on vitamin E composition of GSO, investigations that will include as much varieties as
possible, are needed to single out ones with the highest bio-oil potential., Industrija vina ostavlja za sobom ogromne količine čvrstog organskog otpada koji se
sastoji od peteljki, pokožice i semenki grožđa. Semenke se smatraju najvrednijim delom
komine, jer su bogate uljem i sadrže brojna bioaktivna jedinjenja. Sastav ulja iz semenki
grožđa zavisi pre svega od sorte vinove loze, ali i od faktora sredine i stepena zrelosti ploda.
Cilj ovog rada bilo je ispitivanje raznolikosti hemijskog sastava ulja dobijenog iz semenki
različitih sorti grožđa. U tu svrhu, prikupljeno je osam sorti u istoj fazi zrelosti i iz istog
vinskog regiona. Ispitivanje sastava masnih kiselina vršeno je korišćenjem GC/FID, dok je
HPLC/FD korišćen za analizu koncentracije vitamina E. Linolna kiselina je bila
najzastupljenija u svim uzorcima, zatim oleinska kiselina. Zasićene masne kiseline, kao što su
palmitinska i stearinska kiselina, takođe su bile prisutne (do 20 % od ukupnih metil estara
masnih kiselina). Sorta vinove loze je značajno uticala na sadržaj vitamina E (p<0,01). α-
tokoferol je pronađen u visokim koncentracijama u svim uzorcima. Ulje iz semenki sorte
Širaz sadržalo je oko 25 miligrama α-tokoferola po kilogramu, dok je u ulju sorte Game
kvantifikovana šest puta manja koncentracija ove izoforme vitamina E. Zbir β i γ tokoferola
takođe je značajno varirao, iako se Širaz ponovo istakao sa najvećim sadržajem. δ tokoferol je
pronađen u ulju četiri sorte, u manjim količinama. Generalno, s obzirom na raznovrsnost
sastava vitamina E u ulju iz semenki grožđa, potrebna su opsežnija istraživanja koja će
obuhvatiti veći broj sorti vinove loze kako bi se izdvojile one sa najvećim potencijalom bio-
ulja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Diversity of chemical composition among seed oils obtained from different grape varieties, Raznolikost hemijskog sastava ulja dobijenog iz semenki različitih sorti grožđa",
volume = "72",
number = "4 suplement",
pages = "S217-S218",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4499"
}

Dabetić, N., Todorović, V., Zrnić-Ćirić, M., Đuričić, I.,& Šobajić, S.. (2022). Diversity of chemical composition among seed oils obtained from different grape varieties. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S217-S218.
https://hdl.handle.net/21.15107/rcub_farfar_4499

Dabetić N, Todorović V, Zrnić-Ćirić M, Đuričić I, Šobajić S. Diversity of chemical composition among seed oils obtained from different grape varieties. in Arhiv za farmaciju. 2022;72(4 suplement):S217-S218.
https://hdl.handle.net/21.15107/rcub_farfar_4499 .

Dabetić, Nevena, Todorović, Vanja, Zrnić-Ćirić, Milica, Đuričić, Ivana, Šobajić, Slađana, "Diversity of chemical composition among seed oils obtained from different grape varieties" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S217-S218,
https://hdl.handle.net/21.15107/rcub_farfar_4499 .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Malenović, Anđelija
AU  - Šobajić, Slađana
AU  - Marković, Bojan
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4268
AB  - Winemaking generates large quantities of grape waste consisting of seeds, skin and stalks. Given that grape seeds are a rich source of different bioactive compounds, the main goal of this research was to optimize grape seed phenol extraction using a Box–Behnken design. The following conditions were derived from the optimization process: sample:solvent ratio of 1:10 w/v, extraction time of 30 min and extraction temperature of 50 °C. In addition, a sustainable (green) approach for obtaining extracts was developed by comparing choline chloride:citric acid-ChCit (natural deep eutectic solvent (NADES)) and ethanol extraction methods with respect to phenol profiles and antioxidant activity. This study was conducted on seeds from eight different red grape varieties. Phenolic acids, flavan-3-ols and procyanidins were characterized using HPLC–MS/MS, and the concentration of procyanidin B1 was above 1 mg/g of dry weight in all analyzed samples. The contents of all phenol classes and antioxidant activities were found to not differ significantly between the solvents, but NADES was found to offer valuable advantages. Importantly, ChCit showed a strong affinity toward procyanidins and a strong correlation between antioxidant activity and quantified phenolic compounds.
PB  - MDPI
T2  - Antioxidants
T1  - Optimization of Extraction and HPLC–MS/MS Profiling of Phenolic Compounds from Red Grape Seed Extracts Using Conventional and Deep Eutectic Solvents
VL  - 11
IS  - 8
DO  - 10.3390/antiox11081595
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Malenović, Anđelija and Šobajić, Slađana and Marković, Bojan",
year = "2022",
abstract = "Winemaking generates large quantities of grape waste consisting of seeds, skin and stalks. Given that grape seeds are a rich source of different bioactive compounds, the main goal of this research was to optimize grape seed phenol extraction using a Box–Behnken design. The following conditions were derived from the optimization process: sample:solvent ratio of 1:10 w/v, extraction time of 30 min and extraction temperature of 50 °C. In addition, a sustainable (green) approach for obtaining extracts was developed by comparing choline chloride:citric acid-ChCit (natural deep eutectic solvent (NADES)) and ethanol extraction methods with respect to phenol profiles and antioxidant activity. This study was conducted on seeds from eight different red grape varieties. Phenolic acids, flavan-3-ols and procyanidins were characterized using HPLC–MS/MS, and the concentration of procyanidin B1 was above 1 mg/g of dry weight in all analyzed samples. The contents of all phenol classes and antioxidant activities were found to not differ significantly between the solvents, but NADES was found to offer valuable advantages. Importantly, ChCit showed a strong affinity toward procyanidins and a strong correlation between antioxidant activity and quantified phenolic compounds.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Optimization of Extraction and HPLC–MS/MS Profiling of Phenolic Compounds from Red Grape Seed Extracts Using Conventional and Deep Eutectic Solvents",
volume = "11",
number = "8",
doi = "10.3390/antiox11081595"
}

Dabetić, N., Todorović, V., Malenović, A., Šobajić, S.,& Marković, B.. (2022). Optimization of Extraction and HPLC–MS/MS Profiling of Phenolic Compounds from Red Grape Seed Extracts Using Conventional and Deep Eutectic Solvents. in Antioxidants
MDPI., 11(8).
https://doi.org/10.3390/antiox11081595

Dabetić N, Todorović V, Malenović A, Šobajić S, Marković B. Optimization of Extraction and HPLC–MS/MS Profiling of Phenolic Compounds from Red Grape Seed Extracts Using Conventional and Deep Eutectic Solvents. in Antioxidants. 2022;11(8).
doi:10.3390/antiox11081595 .

Dabetić, Nevena, Todorović, Vanja, Malenović, Anđelija, Šobajić, Slađana, Marković, Bojan, "Optimization of Extraction and HPLC–MS/MS Profiling of Phenolic Compounds from Red Grape Seed Extracts Using Conventional and Deep Eutectic Solvents" in Antioxidants, 11, no. 8 (2022),
https://doi.org/10.3390/antiox11081595 . .

TY  - JOUR
AU  - Đuričić, Ivana
AU  - Gojković, Tamara
AU  - Antonijević, Biljana
AU  - Šobajić, Slađana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4060
AB  - Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of hypercholesterolaemic fatty acids (OFA) for the freshwater group was 18.70 (17.40‒21.30) while the seawater group had a similar range of values 18.90 (17.55‒22.75). Hypocholesterol-aemic fatty acids (DFA) also showed similar ranges for both groups: 68.80 (66‒70.20) for freshwater and 68.40 (64.85‒73.05) for seawater group. The ratio of DHA/EPA ranged from 1.8 for sardine samples and up to 10 for tuna samples, indicating that the amount of DHA in natural samples exceeds the amount of EPA in many cases. The values of ath-erogenic (AI) and thrombogenic index (TI) were lower than 1 for all analysed samples. Conclusion. Sardine and mackerel had the highest content of n-3 LC-PUFA and presented the least expensive sources of EPA and DHA. The low values of AI and TI obtained from studied fish indicate its benefits from a health point of view.
AB  - Uvod/Cilj. Unos n-3 polinezasićenih masnih kiselina (PMK) je od velike važnosti u prevenciji i tretmanu različitih oboljen-ja. Generalno posmatrajući, prosečan unos n-3 PMK je obično značajno niži od utvrđenih preporuka. Lipidi riba sadrže masne kiseline n-3 serije od kojih su najvažnije ei-kozapentaenska (20:5 n-3, EPA) i dokozaheksaenska (20:6 n-3, DHA) masna kiselina. Cilj ove studije bio je odrediti i uporediti lipidni profil i lipidne indekse u 10 različitih vrsta riba dostupnih na tržištu Srbije. Takođe, određen je odnos cene i nutritivne vrednosti odabranih vrsta. Metode. Ispiti-vane su rečne ribe Dunava iz Beogradskog regiona, dok su morske ribe uglavnom vodile poreklo iz Jadranskog mora. Gasna hromatografija sa jonskim detektorom je korišćena za određivanje masnih kiselina u 40 uzoraka nakon lipidne ekstrakcije. Cost-minimization analiza je korišćena za procenu ekonomske koristi. Rezultati. Morske ribe su imale značajno veće vrednosti za parametar flash lipid quality u odnosu na rečne ribe (p < 0,05). Vrednosti hiperholesterolemijskih mas-nih kiselina za grupu rečnih riba [18,70 (17,40‒21,30)] bile su slične vrednostima dobijenim za morske ribe [18,90 (17,55‒22,75)]. Hipoholesterolemijske masne kiseline su takođe pokazale sličan raspon vrednosti za rečne [68.80 (66–70.20)] i morske ribe [68.40 (64.85–73.05)]. Odnos DHA/EPA kretao se od 1,8 za uzorke sardine, do 10 za uzorke tune, što potvrđuje činjenicu da DHA prevazilazi vrednosti za EPA u svim ispitivanim uzorcima. Vrednosti za aterogeni i trombogeni indeks su bile niže od 1 za sve ana-lizirane uzorke. Zaključak. Sardine i skuša su imale najveći sadržaj n-3 PMK i predstavljale su najekonomičniji izvor EPA i DHA. Niske vrednosti za aterogeni i trombogeni in-deks ukazuju na potencijalno povoljan zdravstveni efekat ispitivanih vrsta.
PB  - Belgrade : Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia
T1  - Lipidni profil i zdravstveni značaj najčešće konzumiranih rečnih i morskih riba u populaciji Srbije
VL  - 79
IS  - 1
SP  - 8
EP  - 16
DO  - 10.2298/VSP200212054D
ER  - 

@article{
author = "Đuričić, Ivana and Gojković, Tamara and Antonijević, Biljana and Šobajić, Slađana",
year = "2022",
abstract = "Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of Background/Aim. Dietary intake of n-3 long-chain polyun-saturated fatty acids (LC-PUFA) is important in prevention and treatment of different diseases. In general population, the average intake of n-3 LC-PUFA is often significantly lower than recom-mended levels. Fish lipids are rich sources of these fatty acids, of which the most important are eicosapentaenoic (20:5 n-3, EPA) and docosahexaenoic (22:6 n-3, DHA) fatty acids. This study was designed to determine and compare fat, fatty acids and lipid qual-ity indices in 10 commercial fish species available on the Serbian market, as well as relation between their price and nutritional val-ue. Methods. Freshwater fish originated from the Danube River in the Belgrade Region, while seawater fish were mostly from the Adriatic Sea. A gas chromatography method was used to define fatty acids in 40 fish samples after lipid extraction. Cost-minimization analysis was conducted to assess the economic util-ity. Results. Seawater fish had a significantly higher value of flash lipid quality compared to the freshwater fish (p < 0.05). Value of hypercholesterolaemic fatty acids (OFA) for the freshwater group was 18.70 (17.40‒21.30) while the seawater group had a similar range of values 18.90 (17.55‒22.75). Hypocholesterol-aemic fatty acids (DFA) also showed similar ranges for both groups: 68.80 (66‒70.20) for freshwater and 68.40 (64.85‒73.05) for seawater group. The ratio of DHA/EPA ranged from 1.8 for sardine samples and up to 10 for tuna samples, indicating that the amount of DHA in natural samples exceeds the amount of EPA in many cases. The values of ath-erogenic (AI) and thrombogenic index (TI) were lower than 1 for all analysed samples. Conclusion. Sardine and mackerel had the highest content of n-3 LC-PUFA and presented the least expensive sources of EPA and DHA. The low values of AI and TI obtained from studied fish indicate its benefits from a health point of view., Uvod/Cilj. Unos n-3 polinezasićenih masnih kiselina (PMK) je od velike važnosti u prevenciji i tretmanu različitih oboljen-ja. Generalno posmatrajući, prosečan unos n-3 PMK je obično značajno niži od utvrđenih preporuka. Lipidi riba sadrže masne kiseline n-3 serije od kojih su najvažnije ei-kozapentaenska (20:5 n-3, EPA) i dokozaheksaenska (20:6 n-3, DHA) masna kiselina. Cilj ove studije bio je odrediti i uporediti lipidni profil i lipidne indekse u 10 različitih vrsta riba dostupnih na tržištu Srbije. Takođe, određen je odnos cene i nutritivne vrednosti odabranih vrsta. Metode. Ispiti-vane su rečne ribe Dunava iz Beogradskog regiona, dok su morske ribe uglavnom vodile poreklo iz Jadranskog mora. Gasna hromatografija sa jonskim detektorom je korišćena za određivanje masnih kiselina u 40 uzoraka nakon lipidne ekstrakcije. Cost-minimization analiza je korišćena za procenu ekonomske koristi. Rezultati. Morske ribe su imale značajno veće vrednosti za parametar flash lipid quality u odnosu na rečne ribe (p < 0,05). Vrednosti hiperholesterolemijskih mas-nih kiselina za grupu rečnih riba [18,70 (17,40‒21,30)] bile su slične vrednostima dobijenim za morske ribe [18,90 (17,55‒22,75)]. Hipoholesterolemijske masne kiseline su takođe pokazale sličan raspon vrednosti za rečne [68.80 (66–70.20)] i morske ribe [68.40 (64.85–73.05)]. Odnos DHA/EPA kretao se od 1,8 za uzorke sardine, do 10 za uzorke tune, što potvrđuje činjenicu da DHA prevazilazi vrednosti za EPA u svim ispitivanim uzorcima. Vrednosti za aterogeni i trombogeni indeks su bile niže od 1 za sve ana-lizirane uzorke. Zaključak. Sardine i skuša su imale najveći sadržaj n-3 PMK i predstavljale su najekonomičniji izvor EPA i DHA. Niske vrednosti za aterogeni i trombogeni in-deks ukazuju na potencijalno povoljan zdravstveni efekat ispitivanih vrsta.",
publisher = "Belgrade : Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia, Lipidni profil i zdravstveni značaj najčešće konzumiranih rečnih i morskih riba u populaciji Srbije",
volume = "79",
number = "1",
pages = "8-16",
doi = "10.2298/VSP200212054D"
}

Đuričić, I., Gojković, T., Antonijević, B.,& Šobajić, S.. (2022). Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia. in Vojnosanitetski pregled
Belgrade : Military Medical Academy, INI., 79(1), 8-16.
https://doi.org/10.2298/VSP200212054D

Đuričić I, Gojković T, Antonijević B, Šobajić S. Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia. in Vojnosanitetski pregled. 2022;79(1):8-16.
doi:10.2298/VSP200212054D .

Đuričić, Ivana, Gojković, Tamara, Antonijević, Biljana, Šobajić, Slađana, "Lipid profile and health benefit of commonly consumed fresh water and sea water fish species in the population of Serbia" in Vojnosanitetski pregled, 79, no. 1 (2022):8-16,
https://doi.org/10.2298/VSP200212054D . .

TY  - CONF
AU  - Rajić, Jelena
AU  - Šobajić, Slađana
AU  - Vidović, Bojana
AU  - Bašić, Jasmina
AU  - Živković, Vladimir
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4588
AB  - A considerable interest has been developed over the years for fruits and vegetables
consumption due to their potential biological and health promoting effects. This effect is
attributed to antioxidants. Among the most important natural antioxidants are secondary
plants metabolites, polyphenols. Epidemiological studies indicate that an increase in the
consumption of fruits and vegetables is associated with a decrease in the incidence of
various diseases. The aim of this work was to estimate the intake of polyphenols in the adult
population of the Republic of Serbia based on literature data on polyphenol content in
certain foods and intake data obtained from the Bulletin - Household Budget Survey, 2019
(Statistical Office of the Republic of Serbia), as well as literature data on intake. Based on
literature data on the content of polyphenols in different food groups, it was determined that
the following food groups can be sources of polyphenols in the diet of the Serbian adult
population: vegetables, fruits, coffee, tea, cacao, chocolate, wine, nuts, and fruit juices. Using
the Statistical Office of the Republic of Serbia data, as well as the literature data on the
content of polyphenols in foods that are the major sources of polyphenols in the diet of the
adult Serbia population, the polyphenol intake was estimated. The daily intake of
polyphenols in the adult population of Serbia is about 500 mg. It is necessary to increase the
daily intake of polyphenols in the adult population in Serbia.
AB  - Veliko interesovanje poslednjih godina posvećeno je povećanom unosu voća, povrća i
pozitivnom uticaju na zdravlje. Ovaj efekat pripisuje se i antioksidansima. U najznačajnije
prirodne antioksidanse ubrajaju se sekundarni metaboliti biljaka, polifenoli. Epidemiološke
studije ukazuju da je poveć an unos voća i povrća povezan sa smanjenjem incidence različitih
vrsta bolesti. Cilj ovog rada je, da se na osnovu literaturnih podataka o sadržaju polifenola u
pojedinim namirnicama, na osnovu podataka o unosu namirnica dobijenih iz Biltena –
Anketa o potrošnji domaćinstva, 2019. (Republički zavod za statistiku, Republika Srbija), kao
i literaturnih podataka o unosu, proceni unos polifenola kod odraslog stanovništva
Republike Srbije. Na osnovu literaturnih podataka o sadržaju polifenola u različitim grupama
namirnica utvrđeno je da sledeće grupe namirnica mogu biti izvori polifenola u ishrani
odraslog stanovništva Republike Srbije: povrće, voće, kafa, čaj, kakao, čokolada, vino,
jezgrasto voće i voćni sokovi. Koristeći podatke Republičkog zavoda za statistiku Republike
Srbije, kao i literaturnih podataka za sadržaj polifenola u namirnicama koje su izvor
polifenola u ishrani odraslog stanovništva Srbije izvršena je procena unosa polifenola.
Dnevni unos polifenola kod odraslog stanovništva u Beogradu na osnovu dobijenih podataka
iz Ankete o potrošnji domaćinstva za 2019. godinu i uzimajući u obzir namirnice koji su po
literaturnim podacima izvor polifenola u ishrani odraslog stanovništva srbije iznosi oko 500
mg. Potrebno je povećati unos polifenola u ishrani stanovništva Republike Srbije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Major food sources of polyphenols in Serbian adult population
T1  - Procena dnevnog unosa polifenola u ishrani odraslih u Srbiji
VL  - 72
IS  - 4 suplement
SP  - S489
EP  - S490
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4588
ER  - 

@conference{
author = "Rajić, Jelena and Šobajić, Slađana and Vidović, Bojana and Bašić, Jasmina and Živković, Vladimir",
year = "2022",
abstract = "A considerable interest has been developed over the years for fruits and vegetables
consumption due to their potential biological and health promoting effects. This effect is
attributed to antioxidants. Among the most important natural antioxidants are secondary
plants metabolites, polyphenols. Epidemiological studies indicate that an increase in the
consumption of fruits and vegetables is associated with a decrease in the incidence of
various diseases. The aim of this work was to estimate the intake of polyphenols in the adult
population of the Republic of Serbia based on literature data on polyphenol content in
certain foods and intake data obtained from the Bulletin - Household Budget Survey, 2019
(Statistical Office of the Republic of Serbia), as well as literature data on intake. Based on
literature data on the content of polyphenols in different food groups, it was determined that
the following food groups can be sources of polyphenols in the diet of the Serbian adult
population: vegetables, fruits, coffee, tea, cacao, chocolate, wine, nuts, and fruit juices. Using
the Statistical Office of the Republic of Serbia data, as well as the literature data on the
content of polyphenols in foods that are the major sources of polyphenols in the diet of the
adult Serbia population, the polyphenol intake was estimated. The daily intake of
polyphenols in the adult population of Serbia is about 500 mg. It is necessary to increase the
daily intake of polyphenols in the adult population in Serbia., Veliko interesovanje poslednjih godina posvećeno je povećanom unosu voća, povrća i
pozitivnom uticaju na zdravlje. Ovaj efekat pripisuje se i antioksidansima. U najznačajnije
prirodne antioksidanse ubrajaju se sekundarni metaboliti biljaka, polifenoli. Epidemiološke
studije ukazuju da je poveć an unos voća i povrća povezan sa smanjenjem incidence različitih
vrsta bolesti. Cilj ovog rada je, da se na osnovu literaturnih podataka o sadržaju polifenola u
pojedinim namirnicama, na osnovu podataka o unosu namirnica dobijenih iz Biltena –
Anketa o potrošnji domaćinstva, 2019. (Republički zavod za statistiku, Republika Srbija), kao
i literaturnih podataka o unosu, proceni unos polifenola kod odraslog stanovništva
Republike Srbije. Na osnovu literaturnih podataka o sadržaju polifenola u različitim grupama
namirnica utvrđeno je da sledeće grupe namirnica mogu biti izvori polifenola u ishrani
odraslog stanovništva Republike Srbije: povrće, voće, kafa, čaj, kakao, čokolada, vino,
jezgrasto voće i voćni sokovi. Koristeći podatke Republičkog zavoda za statistiku Republike
Srbije, kao i literaturnih podataka za sadržaj polifenola u namirnicama koje su izvor
polifenola u ishrani odraslog stanovništva Srbije izvršena je procena unosa polifenola.
Dnevni unos polifenola kod odraslog stanovništva u Beogradu na osnovu dobijenih podataka
iz Ankete o potrošnji domaćinstva za 2019. godinu i uzimajući u obzir namirnice koji su po
literaturnim podacima izvor polifenola u ishrani odraslog stanovništva srbije iznosi oko 500
mg. Potrebno je povećati unos polifenola u ishrani stanovništva Republike Srbije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Major food sources of polyphenols in Serbian adult population, Procena dnevnog unosa polifenola u ishrani odraslih u Srbiji",
volume = "72",
number = "4 suplement",
pages = "S489-S490",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4588"
}

Rajić, J., Šobajić, S., Vidović, B., Bašić, J.,& Živković, V.. (2022). Major food sources of polyphenols in Serbian adult population. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S489-S490.
https://hdl.handle.net/21.15107/rcub_farfar_4588

Rajić J, Šobajić S, Vidović B, Bašić J, Živković V. Major food sources of polyphenols in Serbian adult population. in Arhiv za farmaciju. 2022;72(4 suplement):S489-S490.
https://hdl.handle.net/21.15107/rcub_farfar_4588 .

Rajić, Jelena, Šobajić, Slađana, Vidović, Bojana, Bašić, Jasmina, Živković, Vladimir, "Major food sources of polyphenols in Serbian adult population" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S489-S490,
https://hdl.handle.net/21.15107/rcub_farfar_4588 .

TY  - JOUR
AU  - Koss-Mikołajczyk, Izabela
AU  - Todorović, Vanja
AU  - Šobajić, Slađana
AU  - Mahajna, Jamal
AU  - Gerić, Marko
AU  - Tur, Josep A.
AU  - Bartoszek, Agnieszka
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3971
AB  - Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review
VL  - 22
IS  - 18
DO  - 10.3390/ijms221810037
ER  - 

@article{
author = "Koss-Mikołajczyk, Izabela and Todorović, Vanja and Šobajić, Slađana and Mahajna, Jamal and Gerić, Marko and Tur, Josep A. and Bartoszek, Agnieszka",
year = "2021",
abstract = "Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review",
volume = "22",
number = "18",
doi = "10.3390/ijms221810037"
}

Koss-Mikołajczyk, I., Todorović, V., Šobajić, S., Mahajna, J., Gerić, M., Tur, J. A.,& Bartoszek, A.. (2021). Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review. in International Journal of Molecular Sciences
MDPI., 22(18).
https://doi.org/10.3390/ijms221810037

Koss-Mikołajczyk I, Todorović V, Šobajić S, Mahajna J, Gerić M, Tur JA, Bartoszek A. Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review. in International Journal of Molecular Sciences. 2021;22(18).
doi:10.3390/ijms221810037 .

Koss-Mikołajczyk, Izabela, Todorović, Vanja, Šobajić, Slađana, Mahajna, Jamal, Gerić, Marko, Tur, Josep A., Bartoszek, Agnieszka, "Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review" in International Journal of Molecular Sciences, 22, no. 18 (2021),
https://doi.org/10.3390/ijms221810037 . .

TY  - JOUR
AU  - Dodevska, Margarita
AU  - Šobajić, Slađana
AU  - Dragićević, Vesna
AU  - Stanković, Ivan
AU  - Ivanović, Nevena
AU  - Đorđević, Brižita
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3776
AB  - The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)—rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25–35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (−21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.
PB  - MDPI
T2  - Nutrients
T1  - The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults
VL  - 13
IS  - 2
SP  - 1
EP  - 16
DO  - 10.3390/nu13020487
ER  - 

@article{
author = "Dodevska, Margarita and Šobajić, Slađana and Dragićević, Vesna and Stanković, Ivan and Ivanović, Nevena and Đorđević, Brižita",
year = "2021",
abstract = "The impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)—rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25–35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (−21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.",
publisher = "MDPI",
journal = "Nutrients",
title = "The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults",
volume = "13",
number = "2",
pages = "1-16",
doi = "10.3390/nu13020487"
}

Dodevska, M., Šobajić, S., Dragićević, V., Stanković, I., Ivanović, N.,& Đorđević, B.. (2021). The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults. in Nutrients
MDPI., 13(2), 1-16.
https://doi.org/10.3390/nu13020487

Dodevska M, Šobajić S, Dragićević V, Stanković I, Ivanović N, Đorđević B. The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults. in Nutrients. 2021;13(2):1-16.
doi:10.3390/nu13020487 .

Dodevska, Margarita, Šobajić, Slađana, Dragićević, Vesna, Stanković, Ivan, Ivanović, Nevena, Đorđević, Brižita, "The impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults" in Nutrients, 13, no. 2 (2021):1-16,
https://doi.org/10.3390/nu13020487 . .

TY  - CONF
AU  - Todorović, Vanja
AU  - Baranowska, M.
AU  - Suliborska, K.
AU  - Kusznierewicz, B.
AU  - Chrzanowski, W.
AU  - Šobajić, Slađana
AU  - Bartoszek, A.
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5519
AB  - Antioxidant properties of polyphenols are believed to underlie cocoa chemopreventive potential. However, it has been not recognized if these effects are mainly caused by the most abundant components or result from concerted action of major and minor cocoa bioactives as proposed by food synergy concept. This study was aimed at resolving this question. Initially, the cocoa extract composition was determined by HPLC-DAD-MS. Then, bioactivities of cocoa extract and a series of artificial mixtures of cocoa phytochemicals were tested to compare their redox properties in cell-free system and redox-associated biological effects in human colon cancer HT29 cells serving as a model of human alimentary tract. Under cell-free conditions, DPPH test as well as differential pulse voltammetry showed the highest antioxidant activity for cocoa powder extract (CE), but surprisingly, did not reveal any dose-dependent differences between mixtures despite growing concentration and complexity of antioxidants. Basically, to the same conclusion lead determinations of cellular antioxidant activity; CE was the most efficient in cell protection against ROS whereby concentration of catechins in studied solutions had to be above 10 μM to override cellular redox homeostasis. Cell growth inhibition was dose-dependent only for mixtures that consisted of main catechins at narrow range of low concentrations (0.01 – 1 μM C+EC). Neither clear relationship between composition of cocoa phytochemicals and nutrigenomic activity of CE and matching mixtures was spotted. Therefore, our study indicates that the bioactivity of non-toxic complex natural mixtures such as cocoa is strongly affected by interactions between their components, as predicted by food synergy.
PB  - University of Belgrade, Belgrade, Serbia
C3  - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
T1  - Combinations of cocoa antioxidants: what they tell us about the chemopreventive relevance of interactions between food components?
SP  - 47
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5519
ER  - 

@conference{
author = "Todorović, Vanja and Baranowska, M. and Suliborska, K. and Kusznierewicz, B. and Chrzanowski, W. and Šobajić, Slađana and Bartoszek, A.",
year = "2020",
abstract = "Antioxidant properties of polyphenols are believed to underlie cocoa chemopreventive potential. However, it has been not recognized if these effects are mainly caused by the most abundant components or result from concerted action of major and minor cocoa bioactives as proposed by food synergy concept. This study was aimed at resolving this question. Initially, the cocoa extract composition was determined by HPLC-DAD-MS. Then, bioactivities of cocoa extract and a series of artificial mixtures of cocoa phytochemicals were tested to compare their redox properties in cell-free system and redox-associated biological effects in human colon cancer HT29 cells serving as a model of human alimentary tract. Under cell-free conditions, DPPH test as well as differential pulse voltammetry showed the highest antioxidant activity for cocoa powder extract (CE), but surprisingly, did not reveal any dose-dependent differences between mixtures despite growing concentration and complexity of antioxidants. Basically, to the same conclusion lead determinations of cellular antioxidant activity; CE was the most efficient in cell protection against ROS whereby concentration of catechins in studied solutions had to be above 10 μM to override cellular redox homeostasis. Cell growth inhibition was dose-dependent only for mixtures that consisted of main catechins at narrow range of low concentrations (0.01 – 1 μM C+EC). Neither clear relationship between composition of cocoa phytochemicals and nutrigenomic activity of CE and matching mixtures was spotted. Therefore, our study indicates that the bioactivity of non-toxic complex natural mixtures such as cocoa is strongly affected by interactions between their components, as predicted by food synergy.",
publisher = "University of Belgrade, Belgrade, Serbia",
journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade",
title = "Combinations of cocoa antioxidants: what they tell us about the chemopreventive relevance of interactions between food components?",
pages = "47-47",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5519"
}

Todorović, V., Baranowska, M., Suliborska, K., Kusznierewicz, B., Chrzanowski, W., Šobajić, S.,& Bartoszek, A.. (2020). Combinations of cocoa antioxidants: what they tell us about the chemopreventive relevance of interactions between food components?. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
University of Belgrade, Belgrade, Serbia., 47-47.
https://hdl.handle.net/21.15107/rcub_farfar_5519

Todorović V, Baranowska M, Suliborska K, Kusznierewicz B, Chrzanowski W, Šobajić S, Bartoszek A. Combinations of cocoa antioxidants: what they tell us about the chemopreventive relevance of interactions between food components?. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:47-47.
https://hdl.handle.net/21.15107/rcub_farfar_5519 .

Todorović, Vanja, Baranowska, M., Suliborska, K., Kusznierewicz, B., Chrzanowski, W., Šobajić, Slađana, Bartoszek, A., "Combinations of cocoa antioxidants: what they tell us about the chemopreventive relevance of interactions between food components?" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):47-47,
https://hdl.handle.net/21.15107/rcub_farfar_5519 .

TY  - CONF
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Vidović, Bojana
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5397
AB  - Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically active compounds were not completely isolated during the
extraction process. Numerous studies have been conducted in order to achieve the best
extraction recovery. Nevertheless, there is still a question concerning the pretreatment of grape
seeds. The aim of the present study was to investigate the impact of defatting process on total
polyphenol content and antioxidant activity of grape seed extracts. For that purpose seeds were
obtained from eight different grape varieties. Extraction with 70 % ethanol was performed on
both, crude and defatted seeds (lipid fraction was removed by Soxhlet method of extraction).
Determination of total phenolic content (TPC) was done using Folin-Ciocalteu assay.
Antioxidant activity was investigated through four different tests (FRAP, CUPRAC, DPPH and
ABTS) and obtained results were combined in unique Antioxidant Composite Index (ACI). TPC
values ranged from 50.48 to 121.06 and from 38.04 to 108.17 mg GAE/g dry weight for crude
and defatted grape seed extracts, respectively. Higher phenolic content determined in extracts
obtained from crude seeds could be explained by the presence of lipophilic biologically active
compounds in non-removed lipid fraction. Discrepancies between varieties are presumably
present due to different morphological properties of seeds, environmental and agricultural
conditions. Concerning antioxidant activity, all tests were significantly correlated with TPC,
suggesting the strong contribution of phenolic compounds to this biological activity.
PB  - University of Belgrade, Belgrade, Serbia
C3  - Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
T1  - Impact of defatting process on antioxidant potential of grape seeds
SP  - 34
EP  - 34
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5397
ER  - 

@conference{
author = "Dabetić, Nevena and Todorović, Vanja and Vidović, Bojana and Šobajić, Slađana",
year = "2020",
abstract = "Grape seeds contain a wide range of phenolic compounds responsible for its health promoting
effects. Interest for grape seed utilization has increased significantly along with a growing
recognition that present biologically active compounds were not completely isolated during the
extraction process. Numerous studies have been conducted in order to achieve the best
extraction recovery. Nevertheless, there is still a question concerning the pretreatment of grape
seeds. The aim of the present study was to investigate the impact of defatting process on total
polyphenol content and antioxidant activity of grape seed extracts. For that purpose seeds were
obtained from eight different grape varieties. Extraction with 70 % ethanol was performed on
both, crude and defatted seeds (lipid fraction was removed by Soxhlet method of extraction).
Determination of total phenolic content (TPC) was done using Folin-Ciocalteu assay.
Antioxidant activity was investigated through four different tests (FRAP, CUPRAC, DPPH and
ABTS) and obtained results were combined in unique Antioxidant Composite Index (ACI). TPC
values ranged from 50.48 to 121.06 and from 38.04 to 108.17 mg GAE/g dry weight for crude
and defatted grape seed extracts, respectively. Higher phenolic content determined in extracts
obtained from crude seeds could be explained by the presence of lipophilic biologically active
compounds in non-removed lipid fraction. Discrepancies between varieties are presumably
present due to different morphological properties of seeds, environmental and agricultural
conditions. Concerning antioxidant activity, all tests were significantly correlated with TPC,
suggesting the strong contribution of phenolic compounds to this biological activity.",
publisher = "University of Belgrade, Belgrade, Serbia",
journal = "Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade",
title = "Impact of defatting process on antioxidant potential of grape seeds",
pages = "34-34",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5397"
}

Dabetić, N., Todorović, V., Vidović, B.,& Šobajić, S.. (2020). Impact of defatting process on antioxidant potential of grape seeds. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade
University of Belgrade, Belgrade, Serbia., 34-34.
https://hdl.handle.net/21.15107/rcub_farfar_5397

Dabetić N, Todorović V, Vidović B, Šobajić S. Impact of defatting process on antioxidant potential of grape seeds. in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade. 2020;:34-34.
https://hdl.handle.net/21.15107/rcub_farfar_5397 .

Dabetić, Nevena, Todorović, Vanja, Vidović, Bojana, Šobajić, Slađana, "Impact of defatting process on antioxidant potential of grape seeds" in Nutraceuticals in balancing redox status in ageing and age-related diseases WGs Meeting of the NutRedOx COST Action CA16112 Belgrade (2020):34-34,
https://hdl.handle.net/21.15107/rcub_farfar_5397 .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Panić, Manuela
AU  - Radojčić Redovniković, Ivana
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3638
AB  - In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased recognition of environmental pollution has prompted the utilization of green solvents as alternatives. Therefore, the aim of the present study was to exploit deep eutectic solvents (DES) (choline chloride: citric acid and choline chloride: glucose) as solvents for extracting valuable phenolic antioxidants from grapes. Investigation was conducted on ten grape varieties, observing seeds and skin as different matrix. Total polyphenol content (TPC) was determined by Folin-Ciocalteu spectrophotometric microassay. Antioxidant activity was investigated using four different tests and results were combined in a unique Antioxidant Composite Index (ACI) to reveal comprehensive information about this biological activity. Polyphenol compounds were identified and quantified with the aim of HPLC-diode array detector (DAD). Overall results support that DES (particularly choline chloride: citric acid) were comparable to conventional solvent, and in most cases even outperformed acidified aqueous ethanol (concerning extraction efficiency and antioxidant activity). Regardless of varietal distinctions, grape seeds have higher antioxidant capacity compared to grape skin, and such findings are according to their phenol compound concentrations.
PB  - MDPI AG
T2  - Applied Sciences (Switzerland)
T1  - Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin
VL  - 10
IS  - 14
DO  - 10.3390/app10144830
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Panić, Manuela and Radojčić Redovniković, Ivana and Šobajić, Slađana",
year = "2020",
abstract = "In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased recognition of environmental pollution has prompted the utilization of green solvents as alternatives. Therefore, the aim of the present study was to exploit deep eutectic solvents (DES) (choline chloride: citric acid and choline chloride: glucose) as solvents for extracting valuable phenolic antioxidants from grapes. Investigation was conducted on ten grape varieties, observing seeds and skin as different matrix. Total polyphenol content (TPC) was determined by Folin-Ciocalteu spectrophotometric microassay. Antioxidant activity was investigated using four different tests and results were combined in a unique Antioxidant Composite Index (ACI) to reveal comprehensive information about this biological activity. Polyphenol compounds were identified and quantified with the aim of HPLC-diode array detector (DAD). Overall results support that DES (particularly choline chloride: citric acid) were comparable to conventional solvent, and in most cases even outperformed acidified aqueous ethanol (concerning extraction efficiency and antioxidant activity). Regardless of varietal distinctions, grape seeds have higher antioxidant capacity compared to grape skin, and such findings are according to their phenol compound concentrations.",
publisher = "MDPI AG",
journal = "Applied Sciences (Switzerland)",
title = "Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin",
volume = "10",
number = "14",
doi = "10.3390/app10144830"
}

Dabetić, N., Todorović, V., Panić, M., Radojčić Redovniković, I.,& Šobajić, S.. (2020). Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin. in Applied Sciences (Switzerland)
MDPI AG., 10(14).
https://doi.org/10.3390/app10144830

Dabetić N, Todorović V, Panić M, Radojčić Redovniković I, Šobajić S. Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin. in Applied Sciences (Switzerland). 2020;10(14).
doi:10.3390/app10144830 .

Dabetić, Nevena, Todorović, Vanja, Panić, Manuela, Radojčić Redovniković, Ivana, Šobajić, Slađana, "Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin" in Applied Sciences (Switzerland), 10, no. 14 (2020),
https://doi.org/10.3390/app10144830 . .

TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Đuričić, Ivana
AU  - Antić-Stanković, Jelena
AU  - Bašić, Zorica N.
AU  - Vujović, Dragan S.
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3608
AB  - The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.
PB  - Wiley-VCH Verlag
T2  - European Journal of Lipid Science and Technology
T1  - Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment
VL  - 122
IS  - 6
DO  - DOI: 10.1002/ejlt.201900447
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Đuričić, Ivana and Antić-Stanković, Jelena and Bašić, Zorica N. and Vujović, Dragan S. and Šobajić, Slađana",
year = "2020",
abstract = "The amount of organic pomace, left behind agricultural processes, is continuously rising in accordance with industrial progress. Grape pomace, generated in the wine industry all over the world, represents a raw material for obtaining valuable products. Grape seeds are especially rich in oil containing bioactive compounds that can have various health-related effects. The aim of the study is to compare the quality of seed oils obtained from six white grapes, including two Serbian autochthonous varieties. Linoleic acid, associated with numerous health benefits, is the major fatty acid in all samples (≈66% of total); α-tocopherol is the main tocopherol homologue. Total polyphenol content ranges from 73.4 to 104.3 mg of gallic acid equivalents per 100 g. In order to provide comprehensive information about antioxidant capacity of grape seed oil (GSO), three tests are performed (ferric ion reducing antioxidant power; 2,2’-diphenyl-1-picrylhydrazyl, and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical scavenging). Antimicrobial activity is investigated against different strains; however, GSO inhibits the growth of Staphylococcus aureus and Candida albicans. Obtained results are used to develop a novel approach for oil quality assessment. Calculated oil quality scores (OQS) reveal no significant difference between international and autochthonous varieties, although Smederevka stands out as the most potent one. Practical applications: Considering the progressive waste increase in the wine industry and keeping in mind all health-promoting effects of grape seed oil (GSO), it is clearly observed that oil production represents a profitable and sustainable utilization of grape seeds. The results of the present study show that GSO is a rich source of compounds with antioxidant and antimicrobial properties. In addition, this work provides deeper insight into a quality of Serbian autochthonous grape varieties that are still insufficiently explored. Furthermore, the proposed oil quality score could be used as a comprehensive and unbiased method that enables quality assessment of oils. This tool can find practical application in comparing different plant oils regarding their compositional and functional properties. Finally, it would contribute to making some general oil intake recommendations.",
publisher = "Wiley-VCH Verlag",
journal = "European Journal of Lipid Science and Technology",
title = "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment",
volume = "122",
number = "6",
doi = "DOI: 10.1002/ejlt.201900447"
}

Dabetić, N., Todorović, V., Đuričić, I., Antić-Stanković, J., Bašić, Z. N., Vujović, D. S.,& Šobajić, S.. (2020). Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology
Wiley-VCH Verlag., 122(6).
https://doi.org/DOI: 10.1002/ejlt.201900447

Dabetić N, Todorović V, Đuričić I, Antić-Stanković J, Bašić ZN, Vujović DS, Šobajić S. Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment. in European Journal of Lipid Science and Technology. 2020;122(6).
doi:DOI: 10.1002/ejlt.201900447 .

Dabetić, Nevena, Todorović, Vanja, Đuričić, Ivana, Antić-Stanković, Jelena, Bašić, Zorica N., Vujović, Dragan S., Šobajić, Slađana, "Grape Seed Oil Characterization: A Novel Approach for Oil Quality Assessment" in European Journal of Lipid Science and Technology, 122, no. 6 (2020),
https://doi.org/DOI: 10.1002/ejlt.201900447 . .

TY  - JOUR
AU  - Baranowska, Monika
AU  - Suliborska, Klaudia
AU  - Todorović, Vanja
AU  - Kusznierewicz, Barbara
AU  - Chrzanowski, Wojciech
AU  - Šobajić, Slađana
AU  - Bartoszek, Agnieszka
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3584
AB  - Numerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems with the aid of free radicals scavenging method and differential pulse voltammetry, and redox associated anticarcinogenic activities (cellular antioxidant activity, cytotoxicity, nutrigenomic activity) in human colon adenocarcinoma cell line exposed to either cocoa powder extract or artificial mixtures of cocoa bioactives at matching concentrations. In contrast to expectations, our results showed that the stepwise enrichment with antioxidants caused no gradual increase in the antioxidant activity of the model mixtures; also, these model mixtures did not reach the reducing potential of cocoa in the cell-free systems or cellular model employed. Further, the biological activities examined in colon adenocarcinoma cells did not alter in a stepwise manner that could reflect the gradual changes in composition of bioactive ingredients. In conclusion, the experiments presented here showed that the growing complexity of a mixture of phytochemicals seems to create a new redox bioactive substance rather than enrich the mixture with new activities, characteristic of the compound added. It follows that no simple, predictable relationship can be expected between the chemopreventive potential and the composition of real food items containing a complicated set of non-toxic redox active ingredients. Our observations suggest that the interactions between different bioactive compounds and food matrix components are cooperating factors determining the final bioactivity of foods.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
VL  - 154
SP  - 48
EP  - 61
DO  - 10.1016/j.freeradbiomed.2020.04.022
ER  - 

@article{
author = "Baranowska, Monika and Suliborska, Klaudia and Todorović, Vanja and Kusznierewicz, Barbara and Chrzanowski, Wojciech and Šobajić, Slađana and Bartoszek, Agnieszka",
year = "2020",
abstract = "Numerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems with the aid of free radicals scavenging method and differential pulse voltammetry, and redox associated anticarcinogenic activities (cellular antioxidant activity, cytotoxicity, nutrigenomic activity) in human colon adenocarcinoma cell line exposed to either cocoa powder extract or artificial mixtures of cocoa bioactives at matching concentrations. In contrast to expectations, our results showed that the stepwise enrichment with antioxidants caused no gradual increase in the antioxidant activity of the model mixtures; also, these model mixtures did not reach the reducing potential of cocoa in the cell-free systems or cellular model employed. Further, the biological activities examined in colon adenocarcinoma cells did not alter in a stepwise manner that could reflect the gradual changes in composition of bioactive ingredients. In conclusion, the experiments presented here showed that the growing complexity of a mixture of phytochemicals seems to create a new redox bioactive substance rather than enrich the mixture with new activities, characteristic of the compound added. It follows that no simple, predictable relationship can be expected between the chemopreventive potential and the composition of real food items containing a complicated set of non-toxic redox active ingredients. Our observations suggest that the interactions between different bioactive compounds and food matrix components are cooperating factors determining the final bioactivity of foods.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract",
volume = "154",
pages = "48-61",
doi = "10.1016/j.freeradbiomed.2020.04.022"
}

Baranowska, M., Suliborska, K., Todorović, V., Kusznierewicz, B., Chrzanowski, W., Šobajić, S.,& Bartoszek, A.. (2020). Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract. in Free Radical Biology and Medicine
Elsevier., 154, 48-61.
https://doi.org/10.1016/j.freeradbiomed.2020.04.022

Baranowska M, Suliborska K, Todorović V, Kusznierewicz B, Chrzanowski W, Šobajić S, Bartoszek A. Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract. in Free Radical Biology and Medicine. 2020;154:48-61.
doi:10.1016/j.freeradbiomed.2020.04.022 .

Baranowska, Monika, Suliborska, Klaudia, Todorović, Vanja, Kusznierewicz, Barbara, Chrzanowski, Wojciech, Šobajić, Slađana, Bartoszek, Agnieszka, "Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract" in Free Radical Biology and Medicine, 154 (2020):48-61,
https://doi.org/10.1016/j.freeradbiomed.2020.04.022 . .

TY  - JOUR
AU  - Timić, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Boeing, Heiner
AU  - Krajnović, Dušanka
AU  - Đorđević, Brižita
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3730
AB  - This study investigated the behavior of urban-living students related to the salty snacks consumption, and their contribution to salt daily intake. A cross-sectional survey on 1313 urban-living students (16–25 years, 61.4% university students and 38.6% high school students) used a pre-verified questionnaire created specifically for the study. The logistic regression analysis was performed to investigate the factors influencing snack consumption. The results of salt content and the snack consumption frequency were used to evaluate snack contribution to salt intake. All subjects consumed salty snacks, on average several times per week, more often at home and slightly more during periods of intensive studying, with 42% of the participants reporting to consume two or more packages per snacking occasion. Most of the participants consumed such products between main meals, but 10% of them took snacks immediately after the main meal. More high-school students than university students were in the “high snack group” (p < 0.05). The most frequently consumed salty snacks were those with the highest content of salt. Salt intake from snack products for a majority of participants ranged between 0.4 and 1 g/day. The research revealed younger age, home environment and significant contribution to salt intake as critical points in salty snack consumption among urban-living students important for the better understanding of their dietary habits.
PB  - MDPI AG
T2  - Nutrients
T1  - A cross-sectional survey of salty snack consumption among serbian urban-living students and their contribution to salt intake
VL  - 12
IS  - 11
SP  - 1
EP  - 13
DO  - 10.3390/nu12113290
ER  - 

@article{
author = "Timić, Jasmina and Kotur-Stevuljević, Jelena and Boeing, Heiner and Krajnović, Dušanka and Đorđević, Brižita and Šobajić, Slađana",
year = "2020",
abstract = "This study investigated the behavior of urban-living students related to the salty snacks consumption, and their contribution to salt daily intake. A cross-sectional survey on 1313 urban-living students (16–25 years, 61.4% university students and 38.6% high school students) used a pre-verified questionnaire created specifically for the study. The logistic regression analysis was performed to investigate the factors influencing snack consumption. The results of salt content and the snack consumption frequency were used to evaluate snack contribution to salt intake. All subjects consumed salty snacks, on average several times per week, more often at home and slightly more during periods of intensive studying, with 42% of the participants reporting to consume two or more packages per snacking occasion. Most of the participants consumed such products between main meals, but 10% of them took snacks immediately after the main meal. More high-school students than university students were in the “high snack group” (p < 0.05). The most frequently consumed salty snacks were those with the highest content of salt. Salt intake from snack products for a majority of participants ranged between 0.4 and 1 g/day. The research revealed younger age, home environment and significant contribution to salt intake as critical points in salty snack consumption among urban-living students important for the better understanding of their dietary habits.",
publisher = "MDPI AG",
journal = "Nutrients",
title = "A cross-sectional survey of salty snack consumption among serbian urban-living students and their contribution to salt intake",
volume = "12",
number = "11",
pages = "1-13",
doi = "10.3390/nu12113290"
}

Timić, J., Kotur-Stevuljević, J., Boeing, H., Krajnović, D., Đorđević, B.,& Šobajić, S.. (2020). A cross-sectional survey of salty snack consumption among serbian urban-living students and their contribution to salt intake. in Nutrients
MDPI AG., 12(11), 1-13.
https://doi.org/10.3390/nu12113290

Timić J, Kotur-Stevuljević J, Boeing H, Krajnović D, Đorđević B, Šobajić S. A cross-sectional survey of salty snack consumption among serbian urban-living students and their contribution to salt intake. in Nutrients. 2020;12(11):1-13.
doi:10.3390/nu12113290 .

Timić, Jasmina, Kotur-Stevuljević, Jelena, Boeing, Heiner, Krajnović, Dušanka, Đorđević, Brižita, Šobajić, Slađana, "A cross-sectional survey of salty snack consumption among serbian urban-living students and their contribution to salt intake" in Nutrients, 12, no. 11 (2020):1-13,
https://doi.org/10.3390/nu12113290 . .

TY  - JOUR
AU  - Michalickova, Danica
AU  - Belović, Miona
AU  - Ilić, Nebojša
AU  - Kotur-Stevuljević, Jelena
AU  - Slanar, Ondrej
AU  - Šobajić, Slađana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3358
AB  - There is a growing body of evidence that tomato consumption reduces the risk of cardiovascular disease, through antioxidative, anti-inflammatory and hypotensive effects. We compared the effects of polyphenol-enriched and standard tomato juice on parameters of lipid and oxidative status and blood pressure in subjects with stage 1 hypertension. The experimental group (n=13) was supplemented with 200g of tomato fruit juice enriched with 1g of ethanolic extract of whole tomato fruit, while the control group (n=13) was consuming 200g tomato fruit juice. Before and after the treatment, blood samples were collected, and blood pressure was measured. Markers of oxidative stress and antioxidative defense: paraoxonase (PON1), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), pro-oxidant-antioxidant balance (PAB) and C reactive protein (CRP) were determined in serum. Prothrombin time (PT) was measured in the whole blood samples. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant reduction in total cholesterol and LDL-C only in the control group at the end of the study. No significant differences were observed in the remainder of the assessed parameters along the study. In conclusion, tomato juice may have favorable effects on lipid metabolism, but polyphenol fortification does not constitute additional beneficial cardiovascular effects.
PB  - Springer, Dordrecht
T2  - Plant Foods for Human Nutrition
T1  - Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study
VL  - 74
IS  - 1
SP  - 122
EP  - 127
DO  - 10.1007/s11130-019-0714-5
ER  - 

@article{
author = "Michalickova, Danica and Belović, Miona and Ilić, Nebojša and Kotur-Stevuljević, Jelena and Slanar, Ondrej and Šobajić, Slađana",
year = "2019",
abstract = "There is a growing body of evidence that tomato consumption reduces the risk of cardiovascular disease, through antioxidative, anti-inflammatory and hypotensive effects. We compared the effects of polyphenol-enriched and standard tomato juice on parameters of lipid and oxidative status and blood pressure in subjects with stage 1 hypertension. The experimental group (n=13) was supplemented with 200g of tomato fruit juice enriched with 1g of ethanolic extract of whole tomato fruit, while the control group (n=13) was consuming 200g tomato fruit juice. Before and after the treatment, blood samples were collected, and blood pressure was measured. Markers of oxidative stress and antioxidative defense: paraoxonase (PON1), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), pro-oxidant-antioxidant balance (PAB) and C reactive protein (CRP) were determined in serum. Prothrombin time (PT) was measured in the whole blood samples. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant reduction in total cholesterol and LDL-C only in the control group at the end of the study. No significant differences were observed in the remainder of the assessed parameters along the study. In conclusion, tomato juice may have favorable effects on lipid metabolism, but polyphenol fortification does not constitute additional beneficial cardiovascular effects.",
publisher = "Springer, Dordrecht",
journal = "Plant Foods for Human Nutrition",
title = "Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study",
volume = "74",
number = "1",
pages = "122-127",
doi = "10.1007/s11130-019-0714-5"
}

Michalickova, D., Belović, M., Ilić, N., Kotur-Stevuljević, J., Slanar, O.,& Šobajić, S.. (2019). Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study. in Plant Foods for Human Nutrition
Springer, Dordrecht., 74(1), 122-127.
https://doi.org/10.1007/s11130-019-0714-5

Michalickova D, Belović M, Ilić N, Kotur-Stevuljević J, Slanar O, Šobajić S. Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study. in Plant Foods for Human Nutrition. 2019;74(1):122-127.
doi:10.1007/s11130-019-0714-5 .

Michalickova, Danica, Belović, Miona, Ilić, Nebojša, Kotur-Stevuljević, Jelena, Slanar, Ondrej, Šobajić, Slađana, "Comparison of Polyphenol-Enriched Tomato Juice and Standard Tomato Juice for Cardiovascular Benefits in Subjects with Stage 1 Hypertension: a Randomized Controlled Study" in Plant Foods for Human Nutrition, 74, no. 1 (2019):122-127,
https://doi.org/10.1007/s11130-019-0714-5 . .

TY  - JOUR
AU  - Todorović, Vanja
AU  - Dančetović, Anđelka
AU  - Dabetić, Nevena
AU  - Šobajić, Slađana
AU  - Vidović, Bojana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5376
AB  - Začini su aromatični delovi začinskih biljaka, karakterističnog mirisa i uku-
sa, koji se dodaju tokom pripreme hrane radi postizanja odgovarajućih
organoleptičkih osobina, kao i zbog produženja roka trajanja namirnica.
S obzirom na to da predstavljaju izvore prirodnih antioksidanasa, začini
se smatraju i funkcionalnim sastojcima hrane. Osnovni cilj ovog rada jeste
analiza sadržaja ukupnih polifenola i fl avonoida odabranih začina sa na-
šeg tržišta, kao i komparativna procena njihove antioksidativne aktivnosti.
Istraživanje je sprovedeno na komercijalno dostupnim uzorcima deset ra-
zličitih vrsta začinskog bilja. Nakon ekstrakcije etanolom, sadržaj ukupnih
polifenolnih jedinjenja (Total Polyphenol Content, TPC), kao i sadržaj fl a-
vonoida (Total Flavonoid Content, TFC) određen je spektrofotometrijskim
metodama. Procena antioksidativnog potencijala izvršena je korišćenjem
tri različita testa (FRAP, DPPH, ABTS). Na osnovu dobijenih rezultata, račun-
skim putem određene su vrednosti antioksidativnog kompozitnog indeksa
(ACI). Najveći sadržaj TPC utvrđen je za cimet (61,3 ± 3,1 mg GAE/g), slede
ruzmarin (30,2 ± 3,6 mg GAE/g) i origano (21,0 ± 0,8 mg GAE/g), dok je naj-
manji sadržaj bio prisutan u uzorku vlašca (4,3 ± 0,0 mg GAE/g). Sadržaj TFC
kretao se u rasponu od 3,2 ± 0,4 μmol CE/g (kim) do 133,7 ± 6,1 μmol CE/g
(cimet). U pogledu antioksidativnog potencijala, sva tri testa su pokazala
konzistentne rezultate. Utvrđena je statistički značajna povezanost između
sadržaja TPC i ACI vrednosti (r= 0,976; p< 0,01). Na osnovu dobijenih rezul-
tata može se zaključiti da cimet, ruzmatin i origano predstavljaju bogat
izvor polifenolnih jedinjenja i poseduju izražen antioksidativni potencijal.
AB  - Spices are aromatic parts of herbs with characteristic smell and taste. They
are added to food in order to achieve the appropriate organoleptic proper-
ties, as well as to extend their shelf life. Since they are sources of natural an-
tioxidants, spices are considered as functional food ingredients. The main
goal of this research was determination of total polyphenol and fl avonoid
content in selected spices from our market and comparative assessment
of their antioxidant activity. The study was conducted on ten different
commercial samples of herbs. After extraction with ethanol, total polyphe-
nol content (TPC), and total fl avonoid content (TFC) were determined by
spectrophotometric methods. Evaluation of antioxidant potential was
carried out using three different tests (FRAP, DPPH, ABTS). Based on these re-
sults, values of antioxidant composite index (ACI) was determined by com-
putation. The highest content of polyphenolic compounds was found for
cinnamon (61.3±3.1 mg GAE/g), followed by rosemary (30.2±3.6 mg GAE/g)
and oregano (21.0±0.8 mg GAE/g), while the lowest content showed shallot
(4.3±0.0 mg GAE/g). The content of total fl avonoids ranged from 3.2 μmol
CE/g (cumin) to 133.7 μmol CE/g (cinnamon). When it comes to antioxidant
potential, all three tests showed consistent results. A statistically signifi cant
correlation was fi gured out for total polyphenol content and ACI values (r =
0.976, p<0.01). Based on obtained results, it can be concluded that cinna-
mon, rosemary and oregano are the rich sources of polyphenol compounds
and have conspicuous antioxidant potential.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Antioksidativna aktivnost odabranih začina sa tržišta Srbije
T1  - Antioxidant activity of selected spices from Serbian market
VL  - 59
IS  - 2
SP  - 74
EP  - 79
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5376
ER  - 

@article{
author = "Todorović, Vanja and Dančetović, Anđelka and Dabetić, Nevena and Šobajić, Slađana and Vidović, Bojana",
year = "2018",
abstract = "Začini su aromatični delovi začinskih biljaka, karakterističnog mirisa i uku-
sa, koji se dodaju tokom pripreme hrane radi postizanja odgovarajućih
organoleptičkih osobina, kao i zbog produženja roka trajanja namirnica.
S obzirom na to da predstavljaju izvore prirodnih antioksidanasa, začini
se smatraju i funkcionalnim sastojcima hrane. Osnovni cilj ovog rada jeste
analiza sadržaja ukupnih polifenola i fl avonoida odabranih začina sa na-
šeg tržišta, kao i komparativna procena njihove antioksidativne aktivnosti.
Istraživanje je sprovedeno na komercijalno dostupnim uzorcima deset ra-
zličitih vrsta začinskog bilja. Nakon ekstrakcije etanolom, sadržaj ukupnih
polifenolnih jedinjenja (Total Polyphenol Content, TPC), kao i sadržaj fl a-
vonoida (Total Flavonoid Content, TFC) određen je spektrofotometrijskim
metodama. Procena antioksidativnog potencijala izvršena je korišćenjem
tri različita testa (FRAP, DPPH, ABTS). Na osnovu dobijenih rezultata, račun-
skim putem određene su vrednosti antioksidativnog kompozitnog indeksa
(ACI). Najveći sadržaj TPC utvrđen je za cimet (61,3 ± 3,1 mg GAE/g), slede
ruzmarin (30,2 ± 3,6 mg GAE/g) i origano (21,0 ± 0,8 mg GAE/g), dok je naj-
manji sadržaj bio prisutan u uzorku vlašca (4,3 ± 0,0 mg GAE/g). Sadržaj TFC
kretao se u rasponu od 3,2 ± 0,4 μmol CE/g (kim) do 133,7 ± 6,1 μmol CE/g
(cimet). U pogledu antioksidativnog potencijala, sva tri testa su pokazala
konzistentne rezultate. Utvrđena je statistički značajna povezanost između
sadržaja TPC i ACI vrednosti (r= 0,976; p< 0,01). Na osnovu dobijenih rezul-
tata može se zaključiti da cimet, ruzmatin i origano predstavljaju bogat
izvor polifenolnih jedinjenja i poseduju izražen antioksidativni potencijal., Spices are aromatic parts of herbs with characteristic smell and taste. They
are added to food in order to achieve the appropriate organoleptic proper-
ties, as well as to extend their shelf life. Since they are sources of natural an-
tioxidants, spices are considered as functional food ingredients. The main
goal of this research was determination of total polyphenol and fl avonoid
content in selected spices from our market and comparative assessment
of their antioxidant activity. The study was conducted on ten different
commercial samples of herbs. After extraction with ethanol, total polyphe-
nol content (TPC), and total fl avonoid content (TFC) were determined by
spectrophotometric methods. Evaluation of antioxidant potential was
carried out using three different tests (FRAP, DPPH, ABTS). Based on these re-
sults, values of antioxidant composite index (ACI) was determined by com-
putation. The highest content of polyphenolic compounds was found for
cinnamon (61.3±3.1 mg GAE/g), followed by rosemary (30.2±3.6 mg GAE/g)
and oregano (21.0±0.8 mg GAE/g), while the lowest content showed shallot
(4.3±0.0 mg GAE/g). The content of total fl avonoids ranged from 3.2 μmol
CE/g (cumin) to 133.7 μmol CE/g (cinnamon). When it comes to antioxidant
potential, all three tests showed consistent results. A statistically signifi cant
correlation was fi gured out for total polyphenol content and ACI values (r =
0.976, p<0.01). Based on obtained results, it can be concluded that cinna-
mon, rosemary and oregano are the rich sources of polyphenol compounds
and have conspicuous antioxidant potential.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Antioksidativna aktivnost odabranih začina sa tržišta Srbije, Antioxidant activity of selected spices from Serbian market",
volume = "59",
number = "2",
pages = "74-79",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5376"
}

Todorović, V., Dančetović, A., Dabetić, N., Šobajić, S.,& Vidović, B.. (2018). Antioksidativna aktivnost odabranih začina sa tržišta Srbije. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 59(2), 74-79.
https://hdl.handle.net/21.15107/rcub_farfar_5376

Todorović V, Dančetović A, Dabetić N, Šobajić S, Vidović B. Antioksidativna aktivnost odabranih začina sa tržišta Srbije. in Hrana i ishrana. 2018;59(2):74-79.
https://hdl.handle.net/21.15107/rcub_farfar_5376 .

Todorović, Vanja, Dančetović, Anđelka, Dabetić, Nevena, Šobajić, Slađana, Vidović, Bojana, "Antioksidativna aktivnost odabranih začina sa tržišta Srbije" in Hrana i ishrana, 59, no. 2 (2018):74-79,
https://hdl.handle.net/21.15107/rcub_farfar_5376 .

TY  - JOUR
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Arsenijević, Jelena
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3185
AB  - Introduction: Cholesterol homeostasis disruption contributes to the development of different pathologies. Non cholesterol sterols (NCSs) serve as cholesterol synthesis markers (desmosterol and lathosterol), and cholesterol absorption surrogate markers (campesterol, stigmasterol and beta-sitosterol). The study aimed to resolve certain new pre-analytical and analytical problems and ensure a reliable and validated method. Materials and methods: Method optimization, validation and stability studies were executed in human serum and plasma. Freeze-thaw cycles were done with and without antioxidant. Gas chromatography-mass spectrometer (GC-MS) was used for NCSs confirmation and plasticizer identification, while GC-flame ionization detector (GC-FID) was used for NCSs quantitation. Results: Infra-and inter-assay variabilities for all NCSs were 2.75-9.55% and 5.80-7.75% for plasma and 3.10-5.72% and 3.05-10.92% for serum, respectively. Recovery studies showed satisfactory percentage errors for all NCSs: 93.4-105.7% in plasma and 87.5-106.9 in serum. Derivatized samples were stable up to 7 days at 20 degrees C and derivatization yield was affected by presence of plasticizers. Fatty acid amids were identified as interfering plastic leachates. Statistically different NCSs concentrations were observed after the 1st freeze-thaw cycle, in antioxidant-free samples, and after the 4th cycle in antioxidant-enriched samples. Conclusions: All of the in-house procedures proved to be useful for minimizing the preanalytical and analytical variations, as proven by the validation results.
PB  - Elsevier Science BV, Amsterdam
T2  - Clinica Chimica Acta
T1  - Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers
VL  - 478
SP  - 74
EP  - 81
DO  - 10.1016/j.cca.2017.12.032
ER  - 

@article{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Arsenijević, Jelena and Đuričić, Ivana and Šobajić, Slađana and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Introduction: Cholesterol homeostasis disruption contributes to the development of different pathologies. Non cholesterol sterols (NCSs) serve as cholesterol synthesis markers (desmosterol and lathosterol), and cholesterol absorption surrogate markers (campesterol, stigmasterol and beta-sitosterol). The study aimed to resolve certain new pre-analytical and analytical problems and ensure a reliable and validated method. Materials and methods: Method optimization, validation and stability studies were executed in human serum and plasma. Freeze-thaw cycles were done with and without antioxidant. Gas chromatography-mass spectrometer (GC-MS) was used for NCSs confirmation and plasticizer identification, while GC-flame ionization detector (GC-FID) was used for NCSs quantitation. Results: Infra-and inter-assay variabilities for all NCSs were 2.75-9.55% and 5.80-7.75% for plasma and 3.10-5.72% and 3.05-10.92% for serum, respectively. Recovery studies showed satisfactory percentage errors for all NCSs: 93.4-105.7% in plasma and 87.5-106.9 in serum. Derivatized samples were stable up to 7 days at 20 degrees C and derivatization yield was affected by presence of plasticizers. Fatty acid amids were identified as interfering plastic leachates. Statistically different NCSs concentrations were observed after the 1st freeze-thaw cycle, in antioxidant-free samples, and after the 4th cycle in antioxidant-enriched samples. Conclusions: All of the in-house procedures proved to be useful for minimizing the preanalytical and analytical variations, as proven by the validation results.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Clinica Chimica Acta",
title = "Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers",
volume = "478",
pages = "74-81",
doi = "10.1016/j.cca.2017.12.032"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Arsenijević, J., Đuričić, I., Šobajić, S.,& Jelić-Ivanović, Z.. (2018). Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers. in Clinica Chimica Acta
Elsevier Science BV, Amsterdam., 478, 74-81.
https://doi.org/10.1016/j.cca.2017.12.032

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Arsenijević J, Đuričić I, Šobajić S, Jelić-Ivanović Z. Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers. in Clinica Chimica Acta. 2018;478:74-81.
doi:10.1016/j.cca.2017.12.032 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Arsenijević, Jelena, Đuričić, Ivana, Šobajić, Slađana, Jelić-Ivanović, Zorana, "Preanalytical and analytical challenges in gas chromatographic determination of cholesterol synthesis and absorption markers" in Clinica Chimica Acta, 478 (2018):74-81,
https://doi.org/10.1016/j.cca.2017.12.032 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Šobajić, Slađana
AU  - Vidović, Bojana
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3149
AB  - Aim: Balanced nutrition and healthy lifestyle habits are very important, especially in young population. By this way it is possible to prevent many non-communicable diseases. As a health care professionals, pharmacists have very important role in this mission. The aim of this study was to evaluate basic nutritional knowledge and lifestyle habits of pharmacy undergraduate students in the context of their future health profession. Methods: The study group consisted of 591 European undergraduate pharmacy students. The data related to anthropometry, eating and lifestyle habits were obtained based on self-administered cross-sectional survey. Analysis of gender differences was performed using the chi-square test. Statistically significance was set at p value  lt  0.05. Results: Anthropometric characteristics of students showed that 10.5 % female students were underweight, while 62.6% of the males were overweight and 0.7% were obese. Regular breakfast had 80.9% of the students. Breakfast skipping was statistically higher in male participants (p lt 0.05). Only 35% of students reported daily intake of vegetables. Also, low fruit consumption was observed in all students with statistically lower fruit intake in males (p lt 0.05). Consumption of alcohol, fried food and tobacco was not common among students. Basic principle of balanced nutrition was recognized by 58.4% of study population. Conclusion: Results of our study indicate that European pharmacy students have some unsatisfactory eating habits and nutritional knowledge which is already related to their inadequate nutritional status. Our finding suggests that increased level of nutritional education should be incorporated into European pharmacy curriculum.
PB  - Mattioli 1885, Fidenza
T2  - Psychiatry Research
T1  - Nutritional and lifestyle habits of European pharmacy undergraduate students
VL  - 20
IS  - 1
SP  - 38
EP  - 45
DO  - 10.23751/pn.v20i1.5435
ER  - 

@article{
author = "Čakar, Uroš and Šobajić, Slađana and Vidović, Bojana and Đorđević, Brižita",
year = "2018",
abstract = "Aim: Balanced nutrition and healthy lifestyle habits are very important, especially in young population. By this way it is possible to prevent many non-communicable diseases. As a health care professionals, pharmacists have very important role in this mission. The aim of this study was to evaluate basic nutritional knowledge and lifestyle habits of pharmacy undergraduate students in the context of their future health profession. Methods: The study group consisted of 591 European undergraduate pharmacy students. The data related to anthropometry, eating and lifestyle habits were obtained based on self-administered cross-sectional survey. Analysis of gender differences was performed using the chi-square test. Statistically significance was set at p value  lt  0.05. Results: Anthropometric characteristics of students showed that 10.5 % female students were underweight, while 62.6% of the males were overweight and 0.7% were obese. Regular breakfast had 80.9% of the students. Breakfast skipping was statistically higher in male participants (p lt 0.05). Only 35% of students reported daily intake of vegetables. Also, low fruit consumption was observed in all students with statistically lower fruit intake in males (p lt 0.05). Consumption of alcohol, fried food and tobacco was not common among students. Basic principle of balanced nutrition was recognized by 58.4% of study population. Conclusion: Results of our study indicate that European pharmacy students have some unsatisfactory eating habits and nutritional knowledge which is already related to their inadequate nutritional status. Our finding suggests that increased level of nutritional education should be incorporated into European pharmacy curriculum.",
publisher = "Mattioli 1885, Fidenza",
journal = "Psychiatry Research",
title = "Nutritional and lifestyle habits of European pharmacy undergraduate students",
volume = "20",
number = "1",
pages = "38-45",
doi = "10.23751/pn.v20i1.5435"
}

Čakar, U., Šobajić, S., Vidović, B.,& Đorđević, B.. (2018). Nutritional and lifestyle habits of European pharmacy undergraduate students. in Psychiatry Research
Mattioli 1885, Fidenza., 20(1), 38-45.
https://doi.org/10.23751/pn.v20i1.5435

Čakar U, Šobajić S, Vidović B, Đorđević B. Nutritional and lifestyle habits of European pharmacy undergraduate students. in Psychiatry Research. 2018;20(1):38-45.
doi:10.23751/pn.v20i1.5435 .

Čakar, Uroš, Šobajić, Slađana, Vidović, Bojana, Đorđević, Brižita, "Nutritional and lifestyle habits of European pharmacy undergraduate students" in Psychiatry Research, 20, no. 1 (2018):38-45,
https://doi.org/10.23751/pn.v20i1.5435 . .

TY  - JOUR
AU  - Timić, Jasmina
AU  - Đuričić, Ivana
AU  - Ristić-Medić, Danijela K.
AU  - Šobajić, Slađana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3238
AB  - The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted > 80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market
VL  - 83
IS  - 6
SP  - 685
EP  - 698
DO  - 10.2298/JSC180207039T
ER  - 

@article{
author = "Timić, Jasmina and Đuričić, Ivana and Ristić-Medić, Danijela K. and Šobajić, Slađana",
year = "2018",
abstract = "The rapid increase in the consumption of salty snack products has led to increased concern about their composition and nutritional value. The aim of this study was to investigate the fat content and fatty acid profile in salty snack products from the Serbian market. A total of 58 different snack products from 3 categories (Baked products, Chips & flips products, Cereal products) were analyzed. The fatty acid composition was determined using gas chromatography. Total fat content ranged from 3.1 % in expanded rice to 35.7 % in potato chips. Palmitic, oleic and linoleic acids constituted > 80 % of all fatty acids (FAs) in categories Baked products and Chips & flips. Linoleic acid was more abundant in the category Cereal products (15.5-49.3 %). The trans-FAs elaidic (C18:1 - 9t) and linolelaidic FAs (18: 2 - 9t, 12t) were identified in 66 % of the products. The flips products had the highest average t-FAs content (16.3 %), followed by flips group (9.3 %). Potential t-FAs intake from 100 g of analyzed products was in range 0.1-4.9 g. This study provided a large database on saturated fatty acids and t-FAs content in salty snack products and indicated that by consuming only one package of some products, the t-FAs intake could surpass the recommended maximum of 1 % of daily energy.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market",
volume = "83",
number = "6",
pages = "685-698",
doi = "10.2298/JSC180207039T"
}

Timić, J., Đuričić, I., Ristić-Medić, D. K.,& Šobajić, S.. (2018). Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 83(6), 685-698.
https://doi.org/10.2298/JSC180207039T

Timić J, Đuričić I, Ristić-Medić DK, Šobajić S. Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market. in Journal of the Serbian Chemical Society. 2018;83(6):685-698.
doi:10.2298/JSC180207039T .

Timić, Jasmina, Đuričić, Ivana, Ristić-Medić, Danijela K., Šobajić, Slađana, "Fatty acid composition including trans-fatty acids in salty snack food from the Serbian market" in Journal of the Serbian Chemical Society, 83, no. 6 (2018):685-698,
https://doi.org/10.2298/JSC180207039T . .

TY  - JOUR
AU  - Todorović, Vanja
AU  - Milenković, Marina
AU  - Vidović, Bojana
AU  - Todorović, Zoran B.
AU  - Šobajić, Slađana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3014
AB  - Many factors can influence antioxidative and antimicrobial characteristics of plant materials. The quality of cocoa as functional food ingredient is influenced through its processing. The main aim of this study was to test if there is difference in polyphenol content, antioxidant capacity, and antimicrobial activity between nonalkalized and alkalized cocoa powders. To estimate polyphenol and flavonoid content in cocoa samples the spectrophotometric microassays were used. Flavan-3ols were determined with reversed-phase high-performance liquid chromatography (RP-HPLC). Antimicrobial activity against 3 Gram positive bacteria, 4 Gram negative bacteria and 1 strain of yeast was determined using broth microdilution method. Total polyphenol content was 1.8 times lower in alkalized cocoa samples than in natural ones. Epicatechin/catechin ratio was changed due to the process of alkalization in favor of catechin (2.21 in natural and 1.45 in alkalized cocoa powders). Combined results of 3 antioxidative tests (DPPH, FRAP, ABTS) were used for calculation of RACI (Relative Antioxidant Capacity Index) and GAS (Global Antioxidant Score) values that were consistently higher in natural than in alkalized cocoa extracts. Obtained results have shown significant correlations between these values and phenolic content (0.929  lt = r  lt = 0.957, P  lt  0.01). Antimicrobial activity varied from 5.0 to 25.0 mg/ml (MICs), while Candida albicans was the most sensitive tested microorganism. Cocoa powders subjected to alkalization had significantly reduced content of total and specific phenolic compounds and reduced antioxidant capacity (P  lt  0.05), but their antimicrobial activity was equal for Gram-positive bacteria or even significantly enhanced for Gram-negative bacteria.
PB  - Wiley, Hoboken
T2  - Journal of Food Science
T1  - Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders
VL  - 82
IS  - 4
SP  - 1020
EP  - 1027
DO  - 10.1111/1750-3841.13672
ER  - 

@article{
author = "Todorović, Vanja and Milenković, Marina and Vidović, Bojana and Todorović, Zoran B. and Šobajić, Slađana",
year = "2017",
abstract = "Many factors can influence antioxidative and antimicrobial characteristics of plant materials. The quality of cocoa as functional food ingredient is influenced through its processing. The main aim of this study was to test if there is difference in polyphenol content, antioxidant capacity, and antimicrobial activity between nonalkalized and alkalized cocoa powders. To estimate polyphenol and flavonoid content in cocoa samples the spectrophotometric microassays were used. Flavan-3ols were determined with reversed-phase high-performance liquid chromatography (RP-HPLC). Antimicrobial activity against 3 Gram positive bacteria, 4 Gram negative bacteria and 1 strain of yeast was determined using broth microdilution method. Total polyphenol content was 1.8 times lower in alkalized cocoa samples than in natural ones. Epicatechin/catechin ratio was changed due to the process of alkalization in favor of catechin (2.21 in natural and 1.45 in alkalized cocoa powders). Combined results of 3 antioxidative tests (DPPH, FRAP, ABTS) were used for calculation of RACI (Relative Antioxidant Capacity Index) and GAS (Global Antioxidant Score) values that were consistently higher in natural than in alkalized cocoa extracts. Obtained results have shown significant correlations between these values and phenolic content (0.929  lt = r  lt = 0.957, P  lt  0.01). Antimicrobial activity varied from 5.0 to 25.0 mg/ml (MICs), while Candida albicans was the most sensitive tested microorganism. Cocoa powders subjected to alkalization had significantly reduced content of total and specific phenolic compounds and reduced antioxidant capacity (P  lt  0.05), but their antimicrobial activity was equal for Gram-positive bacteria or even significantly enhanced for Gram-negative bacteria.",
publisher = "Wiley, Hoboken",
journal = "Journal of Food Science",
title = "Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders",
volume = "82",
number = "4",
pages = "1020-1027",
doi = "10.1111/1750-3841.13672"
}

Todorović, V., Milenković, M., Vidović, B., Todorović, Z. B.,& Šobajić, S.. (2017). Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders. in Journal of Food Science
Wiley, Hoboken., 82(4), 1020-1027.
https://doi.org/10.1111/1750-3841.13672

Todorović V, Milenković M, Vidović B, Todorović ZB, Šobajić S. Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders. in Journal of Food Science. 2017;82(4):1020-1027.
doi:10.1111/1750-3841.13672 .

Todorović, Vanja, Milenković, Marina, Vidović, Bojana, Todorović, Zoran B., Šobajić, Slađana, "Correlation between Antimicrobial, Antioxidant Activity, and Polyphenols of Alkalized/Nonalkalized Cocoa Powders" in Journal of Food Science, 82, no. 4 (2017):1020-1027,
https://doi.org/10.1111/1750-3841.13672 . .

TY  - JOUR
AU  - Jančić, Dejan
AU  - Todorović, Vanja
AU  - Sircelj, H.
AU  - Dodevska, Margarita
AU  - Beljkas, B.
AU  - Znidarcić, D.
AU  - Šobajić, Slađana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2867
AB  - The aim of this study was to determine biologically active substances (BAS) in the samples of Cichorium intybus L. leaves from different sources (wild and cultivated) in Montenegro and to investigate the potential influence of location and origin on the BAS. Fiber and fatty acid composition, amount of pigments, total phenols and flavonoids and some phenolic acids were analyzed. Antioxidant activity was also determined by three methods (DPPH, FRAP and ABTS) and the results obtained from all tests were used to calculate the antioxidant potency composite index (ACI). The dietary fiber profile confirmed chicory leaves as an important source of fiber. The majority of fats in chicory leaves consist-of unsaturated fatty acids, while saturated fatty acids were represented mainly by palmitic acid. Chlorophyll a and b, lutein and beta-carotene were the main pigments in chicory leaves. ACI index had a good correlation with the total phenolic and total flavonoid content. All these features reinforced the interest of including chicory in modern diet as a healthy alternative to the variety of commonly used vegetables.
PB  - Chiriotti Editori, Pinerolo
T2  - Italian Journal of Food Science
T1  - Biologically active compounds and antioxidant capacity of cichorium intybus l. Leaves from Montenegro
VL  - 29
IS  - 4
SP  - 627
EP  - 643
DO  - 10.14674/IJFS-789
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2867
ER  - 

@article{
author = "Jančić, Dejan and Todorović, Vanja and Sircelj, H. and Dodevska, Margarita and Beljkas, B. and Znidarcić, D. and Šobajić, Slađana",
year = "2017",
abstract = "The aim of this study was to determine biologically active substances (BAS) in the samples of Cichorium intybus L. leaves from different sources (wild and cultivated) in Montenegro and to investigate the potential influence of location and origin on the BAS. Fiber and fatty acid composition, amount of pigments, total phenols and flavonoids and some phenolic acids were analyzed. Antioxidant activity was also determined by three methods (DPPH, FRAP and ABTS) and the results obtained from all tests were used to calculate the antioxidant potency composite index (ACI). The dietary fiber profile confirmed chicory leaves as an important source of fiber. The majority of fats in chicory leaves consist-of unsaturated fatty acids, while saturated fatty acids were represented mainly by palmitic acid. Chlorophyll a and b, lutein and beta-carotene were the main pigments in chicory leaves. ACI index had a good correlation with the total phenolic and total flavonoid content. All these features reinforced the interest of including chicory in modern diet as a healthy alternative to the variety of commonly used vegetables.",
publisher = "Chiriotti Editori, Pinerolo",
journal = "Italian Journal of Food Science",
title = "Biologically active compounds and antioxidant capacity of cichorium intybus l. Leaves from Montenegro",
volume = "29",
number = "4",
pages = "627-643",
doi = "10.14674/IJFS-789",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2867"
}

Jančić, D., Todorović, V., Sircelj, H., Dodevska, M., Beljkas, B., Znidarcić, D.,& Šobajić, S.. (2017). Biologically active compounds and antioxidant capacity of cichorium intybus l. Leaves from Montenegro. in Italian Journal of Food Science
Chiriotti Editori, Pinerolo., 29(4), 627-643.
https://doi.org/10.14674/IJFS-789
https://hdl.handle.net/21.15107/rcub_farfar_2867

Jančić D, Todorović V, Sircelj H, Dodevska M, Beljkas B, Znidarcić D, Šobajić S. Biologically active compounds and antioxidant capacity of cichorium intybus l. Leaves from Montenegro. in Italian Journal of Food Science. 2017;29(4):627-643.
doi:10.14674/IJFS-789
https://hdl.handle.net/21.15107/rcub_farfar_2867 .

Jančić, Dejan, Todorović, Vanja, Sircelj, H., Dodevska, Margarita, Beljkas, B., Znidarcić, D., Šobajić, Slađana, "Biologically active compounds and antioxidant capacity of cichorium intybus l. Leaves from Montenegro" in Italian Journal of Food Science, 29, no. 4 (2017):627-643,
https://doi.org/10.14674/IJFS-789 .,
https://hdl.handle.net/21.15107/rcub_farfar_2867 .

TY  - JOUR
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2954
AB  - Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?
VL  - 55
IS  - 3
SP  - 447
EP  - 457
DO  - 10.1515/cclm-2016-0505
ER  - 

@article{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Đuričić, Ivana and Šobajić, Slađana and Jelić-Ivanović, Zorana",
year = "2017",
abstract = "Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?",
volume = "55",
number = "3",
pages = "447-457",
doi = "10.1515/cclm-2016-0505"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D., Đuričić, I., Šobajić, S.,& Jelić-Ivanović, Z.. (2017). Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 55(3), 447-457.
https://doi.org/10.1515/cclm-2016-0505

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Đuričić I, Šobajić S, Jelić-Ivanović Z. Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Clinical Chemistry and Laboratory Medicine. 2017;55(3):447-457.
doi:10.1515/cclm-2016-0505 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Đuričić, Ivana, Šobajić, Slađana, Jelić-Ivanović, Zorana, "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?" in Clinical Chemistry and Laboratory Medicine, 55, no. 3 (2017):447-457,
https://doi.org/10.1515/cclm-2016-0505 . .

TY  - JOUR
AU  - Jorgačević, B
AU  - Vučević, D
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Mladenović, Dušan
AU  - Vesković, M
AU  - Vukićević, R.J
AU  - Radosavljević, Tatjana S.
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2915
AB  - We used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p  lt  0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p  lt  0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p  lt  0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile.
PB  - Elsevier Ireland Ltd
T2  - Chemistry and Physics of Lipids
T1  - The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
VL  - 204
SP  - 85
EP  - 93
DO  - 10.1016/j.chemphyslip.2017.03.009
ER  - 

@article{
author = "Jorgačević, B and Vučević, D and Đuričić, Ivana and Šobajić, Slađana and Mladenović, Dušan and Vesković, M and Vukićević, R.J and Radosavljević, Tatjana S.",
year = "2017",
abstract = "We used rimonabant to investigate the role of CB1 receptor on hepatic FFAs profile during NAFLD. Male mice C57BL/6 were divided into: control group fed with control diet 20 weeks (C; n = 6); group fed with HFD 20 weeks (HF; n = 6); group fed with control diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Rimonabant (10 mg/kg) was administered daily to HFR and R group by oral gavage. Rimonabant decreased liver palmitic acid proportion in HFR group compared to HF group (p  lt  0.05). Liver stearic and oleic acid proportions were decreased in R group compared to control (p  lt  0.01 respectively). Rimonabant increased liver linoleic and arachidonic acid proportions in HFR group compared to HF group (p  lt  0.01 respectively). CB1 blockade may be useful in the treatment of HFD-induced NAFLD due to modulation of plasma lipid and hepatic FFA profile.",
publisher = "Elsevier Ireland Ltd",
journal = "Chemistry and Physics of Lipids",
title = "The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease",
volume = "204",
pages = "85-93",
doi = "10.1016/j.chemphyslip.2017.03.009"
}

Jorgačević, B., Vučević, D., Đuričić, I., Šobajić, S., Mladenović, D., Vesković, M., Vukićević, R.J,& Radosavljević, T. S.. (2017). The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease. in Chemistry and Physics of Lipids
Elsevier Ireland Ltd., 204, 85-93.
https://doi.org/10.1016/j.chemphyslip.2017.03.009

Jorgačević B, Vučević D, Đuričić I, Šobajić S, Mladenović D, Vesković M, Vukićević R, Radosavljević TS. The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease. in Chemistry and Physics of Lipids. 2017;204:85-93.
doi:10.1016/j.chemphyslip.2017.03.009 .

Jorgačević, B, Vučević, D, Đuričić, Ivana, Šobajić, Slađana, Mladenović, Dušan, Vesković, M, Vukićević, R.J, Radosavljević, Tatjana S., "The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease" in Chemistry and Physics of Lipids, 204 (2017):85-93,
https://doi.org/10.1016/j.chemphyslip.2017.03.009 . .