TY  - JOUR
AU  - Antunović, Marko
AU  - Vučinić, Slavica
AU  - Kotur-Stevuljević, Jelena
AU  - Krstić, Kristijan
AU  - Jović-Stošić, Jasmina
AU  - Kilibarda, Vesna
AU  - Perković-Vukčević, Nataša
AU  - Đorđević, Snežana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4699
AB  - Purpose: The aim of this study was to analyze data on gabapentinoid-related attendances to the National Poison Control Center of Serbia (NPCC), particularly abuse cases; to estimate its changes and to compare it with trends in national consumption rates of these drugs. We also aimed to analyze the main characteristics of the study population and to investigate the major clinical effects in poisoned patients. Patients and Methods: This is a retrospective study of patients admitted to the NPCC for acute poisoning involving gabapentinoids from 1 May 2012 to 1 October 2022. Results: There were 357 (95.5%) pregabalin-related and 17 (4.5%) gabapentin-related poisoning cases in 302 patients. Abuse of pregabalin was detected in 27.8% (84/302), while gabapentin abuse occurred in 0.7% (2/302) of all patients. A steady increase in rates of pregabalin poisoning and abuse cases strongly correlated with the increase in overall consumption of this drug, while there were no significant changes in rates of gabapentin consumption, poisoning and abuse rate during the study period. Most patients who abused pregabalin pregabalin were males (84.5%) and the median age was 26 years (range: 15–45 years). Almost 60% of patients who abused pregabalin (48/84) belonged to the migrant population. Co-ingestions occurred in 89.4% of pregabalin-related cases (319/357), resulting in more severe poisoning. The most often co-ingested drugs were benzodiazepines and among them clonazepam was detected in the largest number of cases. Conclusion: The poisoning and abuse cases involving pregabalin are on the rise in Serbia, which coincided with an increase in its overall consumption during the study period. Isolated pregabalin ingestions resulted in mild poisoning, although severe symptoms such as coma and bradycardia were recorded. When prescribing pregabalin to patients at risk of abuse caution is needed. Strengthening the measures for dispensing of pregabalin may reduce the risks associated with its abuse.
PB  - Dove Medical Press Ltd
T2  - International Journal of General Medicine
T1  - Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study
VL  - 16
VL  - 16
SP  - 1239
SP  - 1250
EP  - 1250
EP  - 1250
DO  - 10.2147/IJGM.S405616
ER  - 

@article{
author = "Antunović, Marko and Vučinić, Slavica and Kotur-Stevuljević, Jelena and Krstić, Kristijan and Jović-Stošić, Jasmina and Kilibarda, Vesna and Perković-Vukčević, Nataša and Đorđević, Snežana",
year = "2023",
abstract = "Purpose: The aim of this study was to analyze data on gabapentinoid-related attendances to the National Poison Control Center of Serbia (NPCC), particularly abuse cases; to estimate its changes and to compare it with trends in national consumption rates of these drugs. We also aimed to analyze the main characteristics of the study population and to investigate the major clinical effects in poisoned patients. Patients and Methods: This is a retrospective study of patients admitted to the NPCC for acute poisoning involving gabapentinoids from 1 May 2012 to 1 October 2022. Results: There were 357 (95.5%) pregabalin-related and 17 (4.5%) gabapentin-related poisoning cases in 302 patients. Abuse of pregabalin was detected in 27.8% (84/302), while gabapentin abuse occurred in 0.7% (2/302) of all patients. A steady increase in rates of pregabalin poisoning and abuse cases strongly correlated with the increase in overall consumption of this drug, while there were no significant changes in rates of gabapentin consumption, poisoning and abuse rate during the study period. Most patients who abused pregabalin pregabalin were males (84.5%) and the median age was 26 years (range: 15–45 years). Almost 60% of patients who abused pregabalin (48/84) belonged to the migrant population. Co-ingestions occurred in 89.4% of pregabalin-related cases (319/357), resulting in more severe poisoning. The most often co-ingested drugs were benzodiazepines and among them clonazepam was detected in the largest number of cases. Conclusion: The poisoning and abuse cases involving pregabalin are on the rise in Serbia, which coincided with an increase in its overall consumption during the study period. Isolated pregabalin ingestions resulted in mild poisoning, although severe symptoms such as coma and bradycardia were recorded. When prescribing pregabalin to patients at risk of abuse caution is needed. Strengthening the measures for dispensing of pregabalin may reduce the risks associated with its abuse.",
publisher = "Dove Medical Press Ltd",
journal = "International Journal of General Medicine",
title = "Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study",
volume = "16, 16",
pages = "1239-1250-1250-1250",
doi = "10.2147/IJGM.S405616"
}

Antunović, M., Vučinić, S., Kotur-Stevuljević, J., Krstić, K., Jović-Stošić, J., Kilibarda, V., Perković-Vukčević, N.,& Đorđević, S.. (2023). Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study. in International Journal of General Medicine
Dove Medical Press Ltd., 16, 1239-1250.
https://doi.org/10.2147/IJGM.S405616

Antunović M, Vučinić S, Kotur-Stevuljević J, Krstić K, Jović-Stošić J, Kilibarda V, Perković-Vukčević N, Đorđević S. Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study. in International Journal of General Medicine. 2023;16:1239-1250.
doi:10.2147/IJGM.S405616 .

Antunović, Marko, Vučinić, Slavica, Kotur-Stevuljević, Jelena, Krstić, Kristijan, Jović-Stošić, Jasmina, Kilibarda, Vesna, Perković-Vukčević, Nataša, Đorđević, Snežana, "Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study" in International Journal of General Medicine, 16 (2023):1239-1250,
https://doi.org/10.2147/IJGM.S405616 . .

TY  - JOUR
AU  - Antunović, Marko
AU  - Vučinić, Slavica
AU  - Kotur-Stevuljević, Jelena
AU  - Krstić, Kristijan
AU  - Jović-Stošić, Jasmina
AU  - Kilibarda, Vesna
AU  - Perković-Vukčević, Nataša
AU  - Đorđević, Snežana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5415
AB  - Purpose: The aim of this study was to analyze data on gabapentinoid-related attendances to the National Poison Control Center of Serbia (NPCC), particularly abuse cases; to estimate its changes and to compare it with trends in national consumption rates of these drugs. We also aimed to analyze the main characteristics of the study population and to investigate the major clinical effects in poisoned patients. Patients and Methods: This is a retrospective study of patients admitted to the NPCC for acute poisoning involving gabapentinoids from 1 May 2012 to 1 October 2022. Results: There were 357 (95.5%) pregabalin-related and 17 (4.5%) gabapentin-related poisoning cases in 302 patients. Abuse of pregabalin was detected in 27.8% (84/302), while gabapentin abuse occurred in 0.7% (2/302) of all patients. A steady increase in rates of pregabalin poisoning and abuse cases strongly correlated with the increase in overall consumption of this drug, while there were no significant changes in rates of gabapentin consumption, poisoning and abuse rate during the study period. Most patients who abused pregabalin pregabalin were males (84.5%) and the median age was 26 years (range: 15–45 years). Almost 60% of patients who abused pregabalin (48/84) belonged to the migrant population. Co-ingestions occurred in 89.4% of pregabalin-related cases (319/357), resulting in more severe poisoning. The most often co-ingested drugs were benzodiazepines and among them clonazepam was detected in the largest number of cases. Conclusion: The poisoning and abuse cases involving pregabalin are on the rise in Serbia, which coincided with an increase in its overall consumption during the study period. Isolated pregabalin ingestions resulted in mild poisoning, although severe symptoms such as coma and bradycardia were recorded. When prescribing pregabalin to patients at risk of abuse caution is needed. Strengthening the measures for dispensing of pregabalin may reduce the risks associated with its abuse.
PB  - Dove Medical Press Ltd
T2  - International Journal of General Medicine
T1  - Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study
VL  - 16
SP  - 1239
EP  - 1250
DO  - 10.2147/IJGM.S405616
ER  - 

@article{
author = "Antunović, Marko and Vučinić, Slavica and Kotur-Stevuljević, Jelena and Krstić, Kristijan and Jović-Stošić, Jasmina and Kilibarda, Vesna and Perković-Vukčević, Nataša and Đorđević, Snežana",
year = "2023",
abstract = "Purpose: The aim of this study was to analyze data on gabapentinoid-related attendances to the National Poison Control Center of Serbia (NPCC), particularly abuse cases; to estimate its changes and to compare it with trends in national consumption rates of these drugs. We also aimed to analyze the main characteristics of the study population and to investigate the major clinical effects in poisoned patients. Patients and Methods: This is a retrospective study of patients admitted to the NPCC for acute poisoning involving gabapentinoids from 1 May 2012 to 1 October 2022. Results: There were 357 (95.5%) pregabalin-related and 17 (4.5%) gabapentin-related poisoning cases in 302 patients. Abuse of pregabalin was detected in 27.8% (84/302), while gabapentin abuse occurred in 0.7% (2/302) of all patients. A steady increase in rates of pregabalin poisoning and abuse cases strongly correlated with the increase in overall consumption of this drug, while there were no significant changes in rates of gabapentin consumption, poisoning and abuse rate during the study period. Most patients who abused pregabalin pregabalin were males (84.5%) and the median age was 26 years (range: 15–45 years). Almost 60% of patients who abused pregabalin (48/84) belonged to the migrant population. Co-ingestions occurred in 89.4% of pregabalin-related cases (319/357), resulting in more severe poisoning. The most often co-ingested drugs were benzodiazepines and among them clonazepam was detected in the largest number of cases. Conclusion: The poisoning and abuse cases involving pregabalin are on the rise in Serbia, which coincided with an increase in its overall consumption during the study period. Isolated pregabalin ingestions resulted in mild poisoning, although severe symptoms such as coma and bradycardia were recorded. When prescribing pregabalin to patients at risk of abuse caution is needed. Strengthening the measures for dispensing of pregabalin may reduce the risks associated with its abuse.",
publisher = "Dove Medical Press Ltd",
journal = "International Journal of General Medicine",
title = "Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study",
volume = "16",
pages = "1239-1250",
doi = "10.2147/IJGM.S405616"
}

Antunović, M., Vučinić, S., Kotur-Stevuljević, J., Krstić, K., Jović-Stošić, J., Kilibarda, V., Perković-Vukčević, N.,& Đorđević, S.. (2023). Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study. in International Journal of General Medicine
Dove Medical Press Ltd., 16, 1239-1250.
https://doi.org/10.2147/IJGM.S405616

Antunović M, Vučinić S, Kotur-Stevuljević J, Krstić K, Jović-Stošić J, Kilibarda V, Perković-Vukčević N, Đorđević S. Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study. in International Journal of General Medicine. 2023;16:1239-1250.
doi:10.2147/IJGM.S405616 .

Antunović, Marko, Vučinić, Slavica, Kotur-Stevuljević, Jelena, Krstić, Kristijan, Jović-Stošić, Jasmina, Kilibarda, Vesna, Perković-Vukčević, Nataša, Đorđević, Snežana, "Rise of Pregabalin Poisoning and Abuse Cases in Serbia: A Ten-Year Retrospective Study" in International Journal of General Medicine, 16 (2023):1239-1250,
https://doi.org/10.2147/IJGM.S405616 . .

TY  - JOUR
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Hayes, Wallace
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4326
AB  - The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.
PB  - Elsevier Inc
T2  - Environmental Research
T1  - New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
VL  - 217
DO  - 10.1016/j.envres.2022.114829
ER  - 

@article{
author = "Buha-Đorđević, Aleksandra and Milovanović, Vesna and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Bulat, Zorica and Đukić-Ćosić, Danijela and Janković, Saša and Vučinić, Slavica and Hayes, Wallace and Antonijević, Biljana",
year = "2023",
abstract = "The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.",
publisher = "Elsevier Inc",
journal = "Environmental Research",
title = "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model",
volume = "217",
doi = "10.1016/j.envres.2022.114829"
}

Buha-Đorđević, A., Milovanović, V., Ćurčić, M., Antonijević-Miljaković, E., Bulat, Z., Đukić-Ćosić, D., Janković, S., Vučinić, S., Hayes, W.,& Antonijević, B.. (2023). New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research
Elsevier Inc., 217.
https://doi.org/10.1016/j.envres.2022.114829

Buha-Đorđević A, Milovanović V, Ćurčić M, Antonijević-Miljaković E, Bulat Z, Đukić-Ćosić D, Janković S, Vučinić S, Hayes W, Antonijević B. New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research. 2023;217.
doi:10.1016/j.envres.2022.114829 .

Buha-Đorđević, Aleksandra, Milovanović, Vesna, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Bulat, Zorica, Đukić-Ćosić, Danijela, Janković, Saša, Vučinić, Slavica, Hayes, Wallace, Antonijević, Biljana, "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model" in Environmental Research, 217 (2023),
https://doi.org/10.1016/j.envres.2022.114829 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Durgo, Ksenija
AU  - Vučinić, Slavica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4626
AB  - Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd.
AB  - Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats
T1  - Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova
VL  - 72
IS  - 4 suplement
SP  - S575
EP  - S576
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4626
ER  - 

@conference{
author = "Ćurčić, Marijana and Janković, Saša and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Durgo, Ksenija and Vučinić, Slavica and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd., Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats, Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova",
volume = "72",
number = "4 suplement",
pages = "S575-S576",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4626"
}

Ćurčić, M., Janković, S., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Živančević, K., Božić, D., Durgo, K., Vučinić, S., Bulat, Z.,& Antonijević, B.. (2022). Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626

Ćurčić M, Janković S, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Živančević K, Božić D, Durgo K, Vučinić S, Bulat Z, Antonijević B. Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju. 2022;72(4 suplement):S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

Ćurčić, Marijana, Janković, Saša, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Durgo, Ksenija, Vučinić, Slavica, Bulat, Zorica, Antonijević, Biljana, "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S575-S576,
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Bulat, Zorica
AU  - Vučinić, Slavica
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Durgo, K
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4349
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - Evaluation of critical effects of the mixture of Cd and BDE-209 in Wistar rats 28 days long exposed
VL  - 368
IS  - Supplement
SP  - S215
EP  - S215
DO  - 10.1016/j.toxlet.2022.07.585
ER  - 

@conference{
author = "Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Bulat, Zorica and Vučinić, Slavica and Baralić, Katarina and Javorac, Dragana and Marić, Đurđica and Durgo, K and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Antonijević, Biljana",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "Evaluation of critical effects of the mixture of Cd and BDE-209 in Wistar rats 28 days long exposed",
volume = "368",
number = "Supplement",
pages = "S215-S215",
doi = "10.1016/j.toxlet.2022.07.585"
}

Ćurčić, M., Buha-Đorđević, A., Bulat, Z., Vučinić, S., Baralić, K., Javorac, D., Marić, Đ., Durgo, K., Antonijević-Miljaković, E., Đukić-Ćosić, D.,& Antonijević, B.. (2022). Evaluation of critical effects of the mixture of Cd and BDE-209 in Wistar rats 28 days long exposed. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S215-S215.
https://doi.org/10.1016/j.toxlet.2022.07.585

Ćurčić M, Buha-Đorđević A, Bulat Z, Vučinić S, Baralić K, Javorac D, Marić Đ, Durgo K, Antonijević-Miljaković E, Đukić-Ćosić D, Antonijević B. Evaluation of critical effects of the mixture of Cd and BDE-209 in Wistar rats 28 days long exposed. in Toxicology Letters. 2022;368(Supplement):S215-S215.
doi:10.1016/j.toxlet.2022.07.585 .

Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Bulat, Zorica, Vučinić, Slavica, Baralić, Katarina, Javorac, Dragana, Marić, Đurđica, Durgo, K, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Antonijević, Biljana, "Evaluation of critical effects of the mixture of Cd and BDE-209 in Wistar rats 28 days long exposed" in Toxicology Letters, 368, no. Supplement (2022):S215-S215,
https://doi.org/10.1016/j.toxlet.2022.07.585 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, V.
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Antonijević, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Matović, Vesna
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3126
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys
VL  - 295
IS  - Supplement 1
SP  - S235
EP  - S236
DO  - 10.1016/j.toxlet.2018.06.984
ER  - 

@conference{
author = "Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Milovanović, V. and Janković, Saša and Vučinić, Slavica and Antonijević, Evica and Đukić-Ćosić, Danijela and Bulat, Zorica and Matović, Vesna and Antonijević, Biljana",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys",
volume = "295",
number = "Supplement 1",
pages = "S235-S236",
doi = "10.1016/j.toxlet.2018.06.984"
}

Ćurčić, M., Buha-Đorđević, A., Milovanović, V., Janković, S., Vučinić, S., Antonijević, E., Đukić-Ćosić, D., Bulat, Z., Matović, V.,& Antonijević, B.. (2018). Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 295(Supplement 1), S235-S236.
https://doi.org/10.1016/j.toxlet.2018.06.984

Ćurčić M, Buha-Đorđević A, Milovanović V, Janković S, Vučinić S, Antonijević E, Đukić-Ćosić D, Bulat Z, Matović V, Antonijević B. Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys. in Toxicology Letters. 2018;295(Supplement 1):S235-S236.
doi:10.1016/j.toxlet.2018.06.984 .

Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Milovanović, V., Janković, Saša, Vučinić, Slavica, Antonijević, Evica, Đukić-Ćosić, Danijela, Bulat, Zorica, Matović, Vesna, Antonijević, Biljana, "Effect assessment of target tissue doses of cadmium and decabrominated diphenyl ether on GSH level in kidneys" in Toxicology Letters, 295, no. Supplement 1 (2018):S235-S236,
https://doi.org/10.1016/j.toxlet.2018.06.984 . .

TY  - JOUR
AU  - Milovanović, Vesna
AU  - Buha, Aleksandra
AU  - Matović, Vesna
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Nakano, Takeshi
AU  - Antonijević, Biljana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3176
AB  - Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats
VL  - 25
IS  - 8
SP  - 7223
EP  - 7230
DO  - 10.1007/s11356-015-5921-5
ER  - 

@article{
author = "Milovanović, Vesna and Buha, Aleksandra and Matović, Vesna and Ćurčić, Marijana and Vučinić, Slavica and Nakano, Takeshi and Antonijević, Biljana",
year = "2018",
abstract = "Fully brominated diphenyl ether (BDE-209) is a flame retardant widely used in plastics and textiles. Because of its high persistence, humans are exposed to it continuously, mainly via dust ingestion. We investigated effects of BDE-209 on renal function and oxidative stress development in the kidney after subacute exposure in rats. Five groups of animals were given by oral gavage 31.25-500 mg BDE-209/kg b.w./day for 28 days, and relative kidney weight, serum urea and creatinine, and oxidative stress parameters in the kidney were determined. Benchmark-dose approach was used for dose response modeling. Serum creatinine was increased, while results obtained for serum urea were inconclusive. Relative kidney weight was not affected by BDE-209. Kidney reduced glutathione was elevated, while superoxide dismutase activity was not changed after BDE-209 treatment. Also, levels of thiobarbituric acid reactive substances (TBARS) were increased and total -SH groups were decreased, which indicated oxidative imbalance. The critical effect dose (CED)/CEDL ratios for the effects on TBARS and total -SH groups indicated estimated CEDs for these markers can be used in risk assessment of BDE-209. Our study results have shown that a relatively low dose of BDE-209 affects kidney function and that oxidative stress is one of the mechanisms of its nephrotoxicity.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats",
volume = "25",
number = "8",
pages = "7223-7230",
doi = "10.1007/s11356-015-5921-5"
}

Milovanović, V., Buha, A., Matović, V., Ćurčić, M., Vučinić, S., Nakano, T.,& Antonijević, B.. (2018). Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats. in Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 25(8), 7223-7230.
https://doi.org/10.1007/s11356-015-5921-5

Milovanović V, Buha A, Matović V, Ćurčić M, Vučinić S, Nakano T, Antonijević B. Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats. in Environmental Science and Pollution Research. 2018;25(8):7223-7230.
doi:10.1007/s11356-015-5921-5 .

Milovanović, Vesna, Buha, Aleksandra, Matović, Vesna, Ćurčić, Marijana, Vučinić, Slavica, Nakano, Takeshi, Antonijević, Biljana, "Oxidative stress and renal toxicity after subacute exposure to decabrominated diphenyl ether in Wistar rats" in Environmental Science and Pollution Research, 25, no. 8 (2018):7223-7230,
https://doi.org/10.1007/s11356-015-5921-5 . .

TY  - JOUR
AU  - Vučinić, Slavica
AU  - Kilibarda, Vesna
AU  - Đorđević, Snežana
AU  - Đorđević, Dragana
AU  - Perković-Vukcević, Nataša
AU  - Vuković-Ercegović, Gordana
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević, Evica
AU  - Brajković, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3196
AB  - A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids
VL  - 69
IS  - 2
SP  - 178
EP  - 185
DO  - 10.2478/aiht-2018-69-3096
ER  - 

@article{
author = "Vučinić, Slavica and Kilibarda, Vesna and Đorđević, Snežana and Đorđević, Dragana and Perković-Vukcević, Nataša and Vuković-Ercegović, Gordana and Antonijević, Biljana and Ćurčić, Marijana and Antonijević, Evica and Brajković, Gordana",
year = "2018",
abstract = "A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids",
volume = "69",
number = "2",
pages = "178-185",
doi = "10.2478/aiht-2018-69-3096"
}

Vučinić, S., Kilibarda, V., Đorđević, S., Đorđević, D., Perković-Vukcević, N., Vuković-Ercegović, G., Antonijević, B., Ćurčić, M., Antonijević, E.,& Brajković, G.. (2018). Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 69(2), 178-185.
https://doi.org/10.2478/aiht-2018-69-3096

Vučinić S, Kilibarda V, Đorđević S, Đorđević D, Perković-Vukcević N, Vuković-Ercegović G, Antonijević B, Ćurčić M, Antonijević E, Brajković G. Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2018;69(2):178-185.
doi:10.2478/aiht-2018-69-3096 .

Vučinić, Slavica, Kilibarda, Vesna, Đorđević, Snežana, Đorđević, Dragana, Perković-Vukcević, Nataša, Vuković-Ercegović, Gordana, Antonijević, Biljana, Ćurčić, Marijana, Antonijević, Evica, Brajković, Gordana, "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 69, no. 2 (2018):178-185,
https://doi.org/10.2478/aiht-2018-69-3096 . .

TY  - CONF
AU  - Bulat, Zorica
AU  - Ćurčić, Marijana
AU  - Antunović, Marko
AU  - Vučinić, Slavica
AU  - Buha-Đorđević, Aleksandra
AU  - Janković, Saša
AU  - Nikolić, Dragica
AU  - Matović, Vesna
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Baralić, Katarina
AU  - Antonijević, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2887
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Cadmium as oxidative stress inducer in brain of subacutely exposed rats and its implication on zinc level
VL  - 280
IS  - Supplement 1
SP  - S152
EP  - S152
DO  - 10.1016/j.toxlet.2017.07.426
ER  - 

@conference{
author = "Bulat, Zorica and Ćurčić, Marijana and Antunović, Marko and Vučinić, Slavica and Buha-Đorđević, Aleksandra and Janković, Saša and Nikolić, Dragica and Matović, Vesna and Đukić-Ćosić, Danijela and Antonijević, Evica and Baralić, Katarina and Antonijević, Biljana",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Cadmium as oxidative stress inducer in brain of subacutely exposed rats and its implication on zinc level",
volume = "280",
number = "Supplement 1",
pages = "S152-S152",
doi = "10.1016/j.toxlet.2017.07.426"
}

Bulat, Z., Ćurčić, M., Antunović, M., Vučinić, S., Buha-Đorđević, A., Janković, S., Nikolić, D., Matović, V., Đukić-Ćosić, D., Antonijević, E., Baralić, K.,& Antonijević, B.. (2017). Cadmium as oxidative stress inducer in brain of subacutely exposed rats and its implication on zinc level. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 280(Supplement 1), S152-S152.
https://doi.org/10.1016/j.toxlet.2017.07.426

Bulat Z, Ćurčić M, Antunović M, Vučinić S, Buha-Đorđević A, Janković S, Nikolić D, Matović V, Đukić-Ćosić D, Antonijević E, Baralić K, Antonijević B. Cadmium as oxidative stress inducer in brain of subacutely exposed rats and its implication on zinc level. in Toxicology Letters. 2017;280(Supplement 1):S152-S152.
doi:10.1016/j.toxlet.2017.07.426 .

Bulat, Zorica, Ćurčić, Marijana, Antunović, Marko, Vučinić, Slavica, Buha-Đorđević, Aleksandra, Janković, Saša, Nikolić, Dragica, Matović, Vesna, Đukić-Ćosić, Danijela, Antonijević, Evica, Baralić, Katarina, Antonijević, Biljana, "Cadmium as oxidative stress inducer in brain of subacutely exposed rats and its implication on zinc level" in Toxicology Letters, 280, no. Supplement 1 (2017):S152-S152,
https://doi.org/10.1016/j.toxlet.2017.07.426 . .

TY  - CONF
AU  - Brajković, Gordana
AU  - Jović-Stošić, Jasmina
AU  - Đorđević, Snežana
AU  - Kilibarda, Vesna
AU  - Ćurčić, Marijana
AU  - Radosavljević-Stevanović, Nataša
AU  - Brajković, Zorica
AU  - Vučinić, Slavica
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2890
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method
VL  - 280
IS  - Supplement 1
SP  - S292
EP  - S292
DO  - 10.1016/j.toxlet.2017.07.820
ER  - 

@conference{
author = "Brajković, Gordana and Jović-Stošić, Jasmina and Đorđević, Snežana and Kilibarda, Vesna and Ćurčić, Marijana and Radosavljević-Stevanović, Nataša and Brajković, Zorica and Vučinić, Slavica",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method",
volume = "280",
number = "Supplement 1",
pages = "S292-S292",
doi = "10.1016/j.toxlet.2017.07.820"
}

Brajković, G., Jović-Stošić, J., Đorđević, S., Kilibarda, V., Ćurčić, M., Radosavljević-Stevanović, N., Brajković, Z.,& Vučinić, S.. (2017). Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 280(Supplement 1), S292-S292.
https://doi.org/10.1016/j.toxlet.2017.07.820

Brajković G, Jović-Stošić J, Đorđević S, Kilibarda V, Ćurčić M, Radosavljević-Stevanović N, Brajković Z, Vučinić S. Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method. in Toxicology Letters. 2017;280(Supplement 1):S292-S292.
doi:10.1016/j.toxlet.2017.07.820 .

Brajković, Gordana, Jović-Stošić, Jasmina, Đorđević, Snežana, Kilibarda, Vesna, Ćurčić, Marijana, Radosavljević-Stevanović, Nataša, Brajković, Zorica, Vučinić, Slavica, "Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method" in Toxicology Letters, 280, no. Supplement 1 (2017):S292-S292,
https://doi.org/10.1016/j.toxlet.2017.07.820 . .

TY  - JOUR
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
AU  - Tsatsakis, Aristidis
AU  - Vassilopoulou, Loukia
AU  - Docea, Anca Oana
AU  - Nosyrev, Alexander E.
AU  - Izotov, Boris N.
AU  - Thiermann, Horst
AU  - Drakoulis, Nikolaos
AU  - Brkić, Dragica
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2856
AB  - Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were disposed of at the sea in the post World War II period, with European, Russian, Japanese and US coasts being the most affected. Sulfur mustard, Lewisite and nerve agents appear to be the most frequently chemical warfare agents disposed of at the sea. Addressing the overall environmental risk, it has been one of the priorities of the world community since that time. Aside from confirming exposure to nerve agents in the alleged use for forensic purposes, the detection and identification of biological markers of exposure are also needed for the diagnosis and treatment of poisoning, in addition to occupational health monitoring for specific profiles of workers. When estimating detrimental effects of acute or potential chronic sub-lethal doses of organophosphorus nerve agents, released accidentally or intentionally into the environment, it is necessary to understand the wide spectra of physical, chemical and toxicological properties of these agents, and predict their ultimate fate in environmental systems.
PB  - Elsevier Science BV, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Environmental exposure to organophosphorus nerve agents
VL  - 56
SP  - 163
EP  - 171
DO  - 10.1016/j.etap.2017.09.004
ER  - 

@article{
author = "Vučinić, Slavica and Antonijević, Biljana and Tsatsakis, Aristidis and Vassilopoulou, Loukia and Docea, Anca Oana and Nosyrev, Alexander E. and Izotov, Boris N. and Thiermann, Horst and Drakoulis, Nikolaos and Brkić, Dragica",
year = "2017",
abstract = "Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were disposed of at the sea in the post World War II period, with European, Russian, Japanese and US coasts being the most affected. Sulfur mustard, Lewisite and nerve agents appear to be the most frequently chemical warfare agents disposed of at the sea. Addressing the overall environmental risk, it has been one of the priorities of the world community since that time. Aside from confirming exposure to nerve agents in the alleged use for forensic purposes, the detection and identification of biological markers of exposure are also needed for the diagnosis and treatment of poisoning, in addition to occupational health monitoring for specific profiles of workers. When estimating detrimental effects of acute or potential chronic sub-lethal doses of organophosphorus nerve agents, released accidentally or intentionally into the environment, it is necessary to understand the wide spectra of physical, chemical and toxicological properties of these agents, and predict their ultimate fate in environmental systems.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Environmental exposure to organophosphorus nerve agents",
volume = "56",
pages = "163-171",
doi = "10.1016/j.etap.2017.09.004"
}

Vučinić, S., Antonijević, B., Tsatsakis, A., Vassilopoulou, L., Docea, A. O., Nosyrev, A. E., Izotov, B. N., Thiermann, H., Drakoulis, N.,& Brkić, D.. (2017). Environmental exposure to organophosphorus nerve agents. in Environmental Toxicology and Pharmacology
Elsevier Science BV, Amsterdam., 56, 163-171.
https://doi.org/10.1016/j.etap.2017.09.004

Vučinić S, Antonijević B, Tsatsakis A, Vassilopoulou L, Docea AO, Nosyrev AE, Izotov BN, Thiermann H, Drakoulis N, Brkić D. Environmental exposure to organophosphorus nerve agents. in Environmental Toxicology and Pharmacology. 2017;56:163-171.
doi:10.1016/j.etap.2017.09.004 .

Vučinić, Slavica, Antonijević, Biljana, Tsatsakis, Aristidis, Vassilopoulou, Loukia, Docea, Anca Oana, Nosyrev, Alexander E., Izotov, Boris N., Thiermann, Horst, Drakoulis, Nikolaos, Brkić, Dragica, "Environmental exposure to organophosphorus nerve agents" in Environmental Toxicology and Pharmacology, 56 (2017):163-171,
https://doi.org/10.1016/j.etap.2017.09.004 . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Antunović, Marko
AU  - Džoković, Maja
AU  - Janković, Saša
AU  - Milovanović, Vesna
AU  - Đorđević, Snežana
AU  - Kilibarda, Vesna
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2552
AB  - It is known that kidneys are target tissue for Cd toxicity but there is not enough literature data on kidney effects of BDE-209. Moreover, Cd as toxic metal and BDE-209 as organic halogenated pollutant can share similar mechanism of action like, oxidative stress which is already assumed. However, how will Cd act as prooxidant in presence of BDE-209 is still not investigated, therefore, the objective of this study was to assess this BDE-209 influence. Results of this study indicated slight decrease in MDA in rat's kidney homogenates after subacute exposure to Cd and/or BDE-209, while SOD activity was increased and content of -SH groups decreased. Based on dose-response assessment, BDE-209 did not influence Cd toxicity mediated by chosen oxidative stress parameters, namely the derived CEDL5 values were the same for single Cd and for Cd given in combination with the BDE-209. In conclusion, dynamic of oxidative process has influence on the parameters levels. Co-exposure with polybrominated organic pollutant did not influence Cd effects on oxidative stress parameters. Having in mind that this is pilot study, performed with only one dose of BDE-209, further investigations are necessary, including changes in dose ranges, duration of exposure etc. Moreover, results contributes to the issue of mixture toxicology even BDE-209 did not influenced oxidative stress as mechanism of Cd toxicity.
AB  - Poznato je da su bubrezi ciljni organ toksičnosti kadmijuma, ali je mnogo manje literaturnih podataka o toksičnim efektima BDE-209 na bubrege. Kadmijum, kao toksičan metal i BDE-209, kao organska halogenovana zagađujuća supstanca mogu imati sličan mehanizam dejstva posredovan oksidativnim stresom. Međutim, kako će Cd da deluje kao prooksidant u prisustvu BDE-209 još uvek nije proučavano, te je cilj ovog rada bio da se proceni uticaj BDE-209 na oksidativni stres posredovan kadmijumom. Rezultati ovog istraživanja ukazuju na blagi pad koncentracije MDA u homogenatima bubrega pacova nakon subakutne ekspozicije Cd i/ili BDE-209, dok se aktivnost SOD povećava i sadržaj - SH grupa smanjuje. Na osnovu procene odnosa doza-odgovor, BDE-209 nije imao uticaja na toksičnost Cd izazvanu posredstvom oksidativnog stresa (posmatrajući odabrane parametre). Potvrda je dobijena i iz izračunatih donjih granica pouzdanosti doze od 5% - CEDL5 jer su vrednosti su bile iste za sam Cd i Cd primenjen u kombinaciji sa BDE-209. Može se zaključiti da dinamika oksidativnih procesa ima uticaj na vrednosti parametara oksidativnog stresa, da stoga istovremena ekspozicija Cd i polibromovanom organskom polutantu nije promenila uticaj samog Cd na parametre oksidativnog stresa. Imajući u vidu da je ovo pilot studija, izvršena sa samo jednom dozom BDE-209, potrebna su dalja istraživanja, uključujući i promene opsega doza, trajanje ekspozicije itd. Pored toga, rezultati ove studije doprinose tumačenju toksikologija smeša, iako BDE-209 nije imao uticaja na oksidativni stres kao mehanizam Cd toksičnosti za date uslove ekspozicije.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - Influence of decabrominated diphenyl ether on cadmium as oxidative stress inducer in kidney: Subacute oral study in rats
T1  - Uticaj dekabromovanog difenil etra na toksičnost kadmijuma posredstvom oksidativnog stresa - subakutna oralna studija na pacovima
VL  - 8
IS  - 1
SP  - 17
EP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2552
ER  - 

@article{
author = "Ćurčić, Marijana and Antunović, Marko and Džoković, Maja and Janković, Saša and Milovanović, Vesna and Đorđević, Snežana and Kilibarda, Vesna and Vučinić, Slavica and Antonijević, Biljana",
year = "2016",
abstract = "It is known that kidneys are target tissue for Cd toxicity but there is not enough literature data on kidney effects of BDE-209. Moreover, Cd as toxic metal and BDE-209 as organic halogenated pollutant can share similar mechanism of action like, oxidative stress which is already assumed. However, how will Cd act as prooxidant in presence of BDE-209 is still not investigated, therefore, the objective of this study was to assess this BDE-209 influence. Results of this study indicated slight decrease in MDA in rat's kidney homogenates after subacute exposure to Cd and/or BDE-209, while SOD activity was increased and content of -SH groups decreased. Based on dose-response assessment, BDE-209 did not influence Cd toxicity mediated by chosen oxidative stress parameters, namely the derived CEDL5 values were the same for single Cd and for Cd given in combination with the BDE-209. In conclusion, dynamic of oxidative process has influence on the parameters levels. Co-exposure with polybrominated organic pollutant did not influence Cd effects on oxidative stress parameters. Having in mind that this is pilot study, performed with only one dose of BDE-209, further investigations are necessary, including changes in dose ranges, duration of exposure etc. Moreover, results contributes to the issue of mixture toxicology even BDE-209 did not influenced oxidative stress as mechanism of Cd toxicity., Poznato je da su bubrezi ciljni organ toksičnosti kadmijuma, ali je mnogo manje literaturnih podataka o toksičnim efektima BDE-209 na bubrege. Kadmijum, kao toksičan metal i BDE-209, kao organska halogenovana zagađujuća supstanca mogu imati sličan mehanizam dejstva posredovan oksidativnim stresom. Međutim, kako će Cd da deluje kao prooksidant u prisustvu BDE-209 još uvek nije proučavano, te je cilj ovog rada bio da se proceni uticaj BDE-209 na oksidativni stres posredovan kadmijumom. Rezultati ovog istraživanja ukazuju na blagi pad koncentracije MDA u homogenatima bubrega pacova nakon subakutne ekspozicije Cd i/ili BDE-209, dok se aktivnost SOD povećava i sadržaj - SH grupa smanjuje. Na osnovu procene odnosa doza-odgovor, BDE-209 nije imao uticaja na toksičnost Cd izazvanu posredstvom oksidativnog stresa (posmatrajući odabrane parametre). Potvrda je dobijena i iz izračunatih donjih granica pouzdanosti doze od 5% - CEDL5 jer su vrednosti su bile iste za sam Cd i Cd primenjen u kombinaciji sa BDE-209. Može se zaključiti da dinamika oksidativnih procesa ima uticaj na vrednosti parametara oksidativnog stresa, da stoga istovremena ekspozicija Cd i polibromovanom organskom polutantu nije promenila uticaj samog Cd na parametre oksidativnog stresa. Imajući u vidu da je ovo pilot studija, izvršena sa samo jednom dozom BDE-209, potrebna su dalja istraživanja, uključujući i promene opsega doza, trajanje ekspozicije itd. Pored toga, rezultati ove studije doprinose tumačenju toksikologija smeša, iako BDE-209 nije imao uticaja na oksidativni stres kao mehanizam Cd toksičnosti za date uslove ekspozicije.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "Influence of decabrominated diphenyl ether on cadmium as oxidative stress inducer in kidney: Subacute oral study in rats, Uticaj dekabromovanog difenil etra na toksičnost kadmijuma posredstvom oksidativnog stresa - subakutna oralna studija na pacovima",
volume = "8",
number = "1",
pages = "17-20",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2552"
}

Ćurčić, M., Antunović, M., Džoković, M., Janković, S., Milovanović, V., Đorđević, S., Kilibarda, V., Vučinić, S.,& Antonijević, B.. (2016). Influence of decabrominated diphenyl ether on cadmium as oxidative stress inducer in kidney: Subacute oral study in rats. in MD - Medical data
Most Art doo, Beograd., 8(1), 17-20.
https://hdl.handle.net/21.15107/rcub_farfar_2552

Ćurčić M, Antunović M, Džoković M, Janković S, Milovanović V, Đorđević S, Kilibarda V, Vučinić S, Antonijević B. Influence of decabrominated diphenyl ether on cadmium as oxidative stress inducer in kidney: Subacute oral study in rats. in MD - Medical data. 2016;8(1):17-20.
https://hdl.handle.net/21.15107/rcub_farfar_2552 .

Ćurčić, Marijana, Antunović, Marko, Džoković, Maja, Janković, Saša, Milovanović, Vesna, Đorđević, Snežana, Kilibarda, Vesna, Vučinić, Slavica, Antonijević, Biljana, "Influence of decabrominated diphenyl ether on cadmium as oxidative stress inducer in kidney: Subacute oral study in rats" in MD - Medical data, 8, no. 1 (2016):17-20,
https://hdl.handle.net/21.15107/rcub_farfar_2552 .

TY  - CONF
AU  - Milovanović, Vladimir
AU  - Buha, Aleksandra
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2658
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Decreased testicular weight in rats treated with polychlorinated biphenyls
VL  - 258
IS  - Supplement
SP  - S292
EP  - S292
DO  - 10.1016/j.toxlet.2016.06.2016
ER  - 

@conference{
author = "Milovanović, Vladimir and Buha, Aleksandra and Ćurčić, Marijana and Vučinić, Slavica and Antonijević, Biljana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Decreased testicular weight in rats treated with polychlorinated biphenyls",
volume = "258",
number = "Supplement",
pages = "S292-S292",
doi = "10.1016/j.toxlet.2016.06.2016"
}

Milovanović, V., Buha, A., Ćurčić, M., Vučinić, S.,& Antonijević, B.. (2016). Decreased testicular weight in rats treated with polychlorinated biphenyls. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 258(Supplement), S292-S292.
https://doi.org/10.1016/j.toxlet.2016.06.2016

Milovanović V, Buha A, Ćurčić M, Vučinić S, Antonijević B. Decreased testicular weight in rats treated with polychlorinated biphenyls. in Toxicology Letters. 2016;258(Supplement):S292-S292.
doi:10.1016/j.toxlet.2016.06.2016 .

Milovanović, Vladimir, Buha, Aleksandra, Ćurčić, Marijana, Vučinić, Slavica, Antonijević, Biljana, "Decreased testicular weight in rats treated with polychlorinated biphenyls" in Toxicology Letters, 258, no. Supplement (2016):S292-S292,
https://doi.org/10.1016/j.toxlet.2016.06.2016 . .

TY  - CONF
AU  - Đorđević, S.
AU  - Antunović, M.
AU  - Kilibarda, Vesna
AU  - Brajković, Gordana
AU  - Ćurčić, Marijana
AU  - Jović-Stošić, Jasmina
AU  - Vučinić, Slavica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2644
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data
VL  - 258
SP  - S104
EP  - S105
DO  - 10.1016/j.toxlet.2016.06.1440
ER  - 

@conference{
author = "Đorđević, S. and Antunović, M. and Kilibarda, Vesna and Brajković, Gordana and Ćurčić, Marijana and Jović-Stošić, Jasmina and Vučinić, Slavica",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data",
volume = "258",
pages = "S104-S105",
doi = "10.1016/j.toxlet.2016.06.1440"
}

Đorđević, S., Antunović, M., Kilibarda, V., Brajković, G., Ćurčić, M., Jović-Stošić, J.,& Vučinić, S.. (2016). Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 258, S104-S105.
https://doi.org/10.1016/j.toxlet.2016.06.1440

Đorđević S, Antunović M, Kilibarda V, Brajković G, Ćurčić M, Jović-Stošić J, Vučinić S. Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data. in Toxicology Letters. 2016;258:S104-S105.
doi:10.1016/j.toxlet.2016.06.1440 .

Đorđević, S., Antunović, M., Kilibarda, Vesna, Brajković, Gordana, Ćurčić, Marijana, Jović-Stošić, Jasmina, Vučinić, Slavica, "Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data" in Toxicology Letters, 258 (2016):S104-S105,
https://doi.org/10.1016/j.toxlet.2016.06.1440 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Buha, Aleksandra
AU  - Milovanović, V.
AU  - Antunović, M.
AU  - Đorđević, S.
AU  - Vučinić, Slavica
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Matović, Vesna
AU  - Antonijević, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2660
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Influence of decabrominated diphenyl ether on oxidative stress in brain caused by cadmium
VL  - 258
IS  - Supplement
SP  - S320
EP  - S320
DO  - 10.1016/j.toxlet.2016.06.2089
ER  - 

@conference{
author = "Ćurčić, Marijana and Buha, Aleksandra and Milovanović, V. and Antunović, M. and Đorđević, S. and Vučinić, Slavica and Đukić-Ćosić, Danijela and Bulat, Zorica and Matović, Vesna and Antonijević, Biljana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Influence of decabrominated diphenyl ether on oxidative stress in brain caused by cadmium",
volume = "258",
number = "Supplement",
pages = "S320-S320",
doi = "10.1016/j.toxlet.2016.06.2089"
}

Ćurčić, M., Buha, A., Milovanović, V., Antunović, M., Đorđević, S., Vučinić, S., Đukić-Ćosić, D., Bulat, Z., Matović, V.,& Antonijević, B.. (2016). Influence of decabrominated diphenyl ether on oxidative stress in brain caused by cadmium. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 258(Supplement), S320-S320.
https://doi.org/10.1016/j.toxlet.2016.06.2089

Ćurčić M, Buha A, Milovanović V, Antunović M, Đorđević S, Vučinić S, Đukić-Ćosić D, Bulat Z, Matović V, Antonijević B. Influence of decabrominated diphenyl ether on oxidative stress in brain caused by cadmium. in Toxicology Letters. 2016;258(Supplement):S320-S320.
doi:10.1016/j.toxlet.2016.06.2089 .

Ćurčić, Marijana, Buha, Aleksandra, Milovanović, V., Antunović, M., Đorđević, S., Vučinić, Slavica, Đukić-Ćosić, Danijela, Bulat, Zorica, Matović, Vesna, Antonijević, Biljana, "Influence of decabrominated diphenyl ether on oxidative stress in brain caused by cadmium" in Toxicology Letters, 258, no. Supplement (2016):S320-S320,
https://doi.org/10.1016/j.toxlet.2016.06.2089 . .

TY  - JOUR
AU  - Antonijević, Evica
AU  - Musilek, Kamil
AU  - Kuca, Kamil
AU  - Đukić-Ćosić, Danijela
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2655
AB  - As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing. In this study, experimental bispyridinium oximes K027 and K203, which have shown promising results in the last decade of research, were examined in vivo for their therapeutic and reactivating ability in acute poisoning by the direct AChE-inhibitor dichlorvos (DDVP), used as a dimethyl OP structural model. Additionally, the efficacy of oximes K027 and K203 was compared with the efficacy of four oximes (pralidoxime, trimedoxime, obidoxime and HI-6), already used in efficacy experiments and human medicine. To evaluate therapeutic efficacy, groups of Wistar rats were treated with equitoxic doses of oximes (5% LD50, i.m.) and/or atropine (10 mg/kg, i.m.) immediately after s.c. DDVP challenge (4-6 doses). Using the same antidotal protocol, AChE activity was measured in erythrocytes, diaphragm and brain 60 min after s.c. DDVP exposure (75% LD50). The oxime K027 was the most efficacious in reducing the DDVP induced lethal effect in rats, while the oxime K203 was more efficacious than trimedoxime, pralidoxime and HI-6. Significant reactivation of DDVP inhibited AChE was achieved only with oxime K027 or its combination with atropine in erythocytes and the diaphragm. Moreover, the acute i.m. toxicity of oxime K027 in rats was lower than all other tested oximes. The results of this study support previous studies considering the oxime K027 as a promising experimental oxime structure for further testing against structurally-different OP compounds.
PB  - Elsevier Science BV, Amsterdam
T2  - Neurotoxicology
T1  - Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor
VL  - 55
SP  - 33
EP  - 39
DO  - 10.1016/j.neuro.2016.05.006
ER  - 

@article{
author = "Antonijević, Evica and Musilek, Kamil and Kuca, Kamil and Đukić-Ćosić, Danijela and Vučinić, Slavica and Antonijević, Biljana",
year = "2016",
abstract = "As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing. In this study, experimental bispyridinium oximes K027 and K203, which have shown promising results in the last decade of research, were examined in vivo for their therapeutic and reactivating ability in acute poisoning by the direct AChE-inhibitor dichlorvos (DDVP), used as a dimethyl OP structural model. Additionally, the efficacy of oximes K027 and K203 was compared with the efficacy of four oximes (pralidoxime, trimedoxime, obidoxime and HI-6), already used in efficacy experiments and human medicine. To evaluate therapeutic efficacy, groups of Wistar rats were treated with equitoxic doses of oximes (5% LD50, i.m.) and/or atropine (10 mg/kg, i.m.) immediately after s.c. DDVP challenge (4-6 doses). Using the same antidotal protocol, AChE activity was measured in erythrocytes, diaphragm and brain 60 min after s.c. DDVP exposure (75% LD50). The oxime K027 was the most efficacious in reducing the DDVP induced lethal effect in rats, while the oxime K203 was more efficacious than trimedoxime, pralidoxime and HI-6. Significant reactivation of DDVP inhibited AChE was achieved only with oxime K027 or its combination with atropine in erythocytes and the diaphragm. Moreover, the acute i.m. toxicity of oxime K027 in rats was lower than all other tested oximes. The results of this study support previous studies considering the oxime K027 as a promising experimental oxime structure for further testing against structurally-different OP compounds.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Neurotoxicology",
title = "Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor",
volume = "55",
pages = "33-39",
doi = "10.1016/j.neuro.2016.05.006"
}

Antonijević, E., Musilek, K., Kuca, K., Đukić-Ćosić, D., Vučinić, S.,& Antonijević, B.. (2016). Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor. in Neurotoxicology
Elsevier Science BV, Amsterdam., 55, 33-39.
https://doi.org/10.1016/j.neuro.2016.05.006

Antonijević E, Musilek K, Kuca K, Đukić-Ćosić D, Vučinić S, Antonijević B. Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor. in Neurotoxicology. 2016;55:33-39.
doi:10.1016/j.neuro.2016.05.006 .

Antonijević, Evica, Musilek, Kamil, Kuca, Kamil, Đukić-Ćosić, Danijela, Vučinić, Slavica, Antonijević, Biljana, "Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor" in Neurotoxicology, 55 (2016):33-39,
https://doi.org/10.1016/j.neuro.2016.05.006 . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Tanasković, Slađana
AU  - Stanković, Sanja
AU  - Janković, Saša
AU  - Antunović, Marko
AU  - Đorđević, Snežana
AU  - Kilibarda, Vesna
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2474
AB  - Background/Aim. Based on numerous studies in animals, the most prominent toxic effects of decabrominated di-phenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats. Methods. Effects were examined on male Wistar rats, weighing 200-240 g, exposed to doses of 1,000, 2,000 or 4,000 mg BDE-209/kg body weight (bw)/day by gavage during 28 days. Animals were treated according to the decision of the Ethics Committee of the Military Medical Academy, No 9667-1/2011. Evaluation of the hepatotoxic effect was based on: relative liver weight water and food intake, biochemical parameters of liver function [aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama glutamyl transferase (γ-GT)], and oxidative stress parameters in liver homogenates [malondialdehiyde (MDA), superoxide dismutase (SOD), -SH] and morphological and pathohistological changes in the liver. For the assessment of internal dose - response relationship, lower confidence limit of Benchmark dose (BMDL) of 5% or 10% i.e. BMDL5 or BMDL10, were calculated using PROAST software. Results. After the application of 1,000, 2,000 or 4,000 mg BDE-209/kg bw/day, the concentrations of BDE-209 measured in liver were 0.269, 0.569 and 0.859 mg/kg of liver wet weight, (ww) respectively. Internal doses correlated with external (r = 0.972; p  lt  0.05) according to equation: internal dose (mg BDE-209/kg of liver ww) = 0.0002 ' external dose (mg/kg bw/day) + 0.0622. Hepato-toxicity was demonstrated based on significant increase in AST and γ-GT activities and the degree of histopathological changes. The lowest BMDL5 of 0.07228 mg BDE-209/kg of liver ww, correlating to external dose of 39 mg/kg/day, indicated the increase of AST activity as the most sensitive biomarker of BDE-209 hepatotoxicity in subacutely ex-posed rats. Conclusion. The results of the present work add up to the issue of BDE-209 toxicity profile with a focus on relationship between internal dose and hepatotoxicity. Critical internal dose for the effect on AST of 0.07 mg/kg of liver ww, corresponding to external dose of 39 mg/kg/day, is the lowest dose ever observed among the studies on BDE-209 hepatotoxicity. For the persistent sub-stances with low absorption rate such as BDE-209, critical effect based on internal dose in majority of cases is considered as more precisely defined than the effect established based on external dose, particularly.
AB  - Uvod/Cilj. Prema podacima iz brojnih studija na životinjama, dekabromovani difeniletar (BDE-209) najznačajnije toksične efekte ispoljava na jetri, homeostazi hormona štitaste žlezde, reproduktivnom i nervnom sistemu. BDE-209 ispoljava toksične efekte delom preko receptora za aromatične ugljovodonike (Ah) i posledične indukcije mikrozomalnih enzima jetre. Cilj rada bio je procena hepatotoksičnog efekta u odnosu na dozu BDE-209 u ciljnom tkivu kod subakutno oralno eksponovanih Wistar pacova. Metode. Efekti su ispitivani na mužjacima Wistar pacova, mase 200-240 g, koji su putem oralne sonde primali doze od 1 000, 2 000 ili 4 000 mg BDE-209/kg telesne mase (tm) dan, tokom 28 dana. Životinje su tretirane u skladu sa odlukom Etičkog komiteta Vojnomedicinske akademije u Beogradu br. 9667-1/2011. Procena hepatotoksičnih efekata bazirana je na merenju relativne mase jetre, unosa vode i hrane, biohemijskih parametara funkcije jetre [aspartat aminotransferaza (AST), alanin amino-transferaza (ALT), alkalna fosfataza (ALP), gama glutamil transferaza (γ-GT)], parametara oksidativnog stresa u homogenatima jetre [malondialdehid (MDA), superoksid dizmutaza (SOD), -SH)] i morfoloških i histoloških promena na jetri. Za procenu odnosa interna doza - odgovor izračunavana je donja granica pouzdanosti granične Benchmark doze (BMDL) od 5% (BMDL5) ili 10% (BMDL10) primenom PROAST softvera. Rezultati. Koncentracije BDE-209 iznosile su 0,269, 0,569 i 0,859 mg/kg jetre nakon aplikacije 1 000, 2 000, odnosno 4 000 mg BDE-209/kg tm/dan. Interna doza u našoj studiji korelisala je sa eksternom dozom prema jednačini: interna doza (mg BDE-209/kg jetre) = 0,0002 ' eksterna doza (mg/kg tm/dan) + 0,0622 (r = 0,972; p  lt  0,05). Hepatotoksičnost je potvrđena na osnovu nalaza o povećanju aktivnosti enzima AST i γ-GT, kao i stepena patohistološkog oštećenja jetre. Najniža BMDL5 u eksperimentu od 0,07228 mg BDE-209/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan izračunata je za aktivnost AST i ukazuje na to da je aktivnost AST ujedno i najosetljiviji biomarker hepatotoksičnosti BDE-209 kod subakutno eksponovanih pacova. Zaključak. Rezultati prezentovane studije daju doprinos pitanju toksikološkog profila BDE-209 sa fokusom na odnos između interne doze i hepatotoksičnih efekata. Kritična interna doza za efekat na AST od 0,07 mg/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan, jeste ujedno i najniža kritična doza do sada definisana za hepatotoksične efekte BDE-209. Kritičan efekat koji se bazira na dozi u ciljnom tkivu u većini slučajeva može se smatrati preciznije definisanim od kritičnog efekta definisanog na bazi oralno primenjene doze, naročito za nedegradabilne supstance sa niskim stepenom apsorpcije, kao što je BDE-209.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats
T1  - Odnos hepatotoksičnosti i doze dekabromovanog difeniletra u ciljnom tkivu kod subakutno izloženih Wistar pacova
VL  - 72
IS  - 5
SP  - 405
EP  - 413
DO  - 10.2298/VSP1505405C
ER  - 

@article{
author = "Ćurčić, Marijana and Tanasković, Slađana and Stanković, Sanja and Janković, Saša and Antunović, Marko and Đorđević, Snežana and Kilibarda, Vesna and Vučinić, Slavica and Antonijević, Biljana",
year = "2015",
abstract = "Background/Aim. Based on numerous studies in animals, the most prominent toxic effects of decabrominated di-phenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats. Methods. Effects were examined on male Wistar rats, weighing 200-240 g, exposed to doses of 1,000, 2,000 or 4,000 mg BDE-209/kg body weight (bw)/day by gavage during 28 days. Animals were treated according to the decision of the Ethics Committee of the Military Medical Academy, No 9667-1/2011. Evaluation of the hepatotoxic effect was based on: relative liver weight water and food intake, biochemical parameters of liver function [aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama glutamyl transferase (γ-GT)], and oxidative stress parameters in liver homogenates [malondialdehiyde (MDA), superoxide dismutase (SOD), -SH] and morphological and pathohistological changes in the liver. For the assessment of internal dose - response relationship, lower confidence limit of Benchmark dose (BMDL) of 5% or 10% i.e. BMDL5 or BMDL10, were calculated using PROAST software. Results. After the application of 1,000, 2,000 or 4,000 mg BDE-209/kg bw/day, the concentrations of BDE-209 measured in liver were 0.269, 0.569 and 0.859 mg/kg of liver wet weight, (ww) respectively. Internal doses correlated with external (r = 0.972; p  lt  0.05) according to equation: internal dose (mg BDE-209/kg of liver ww) = 0.0002 ' external dose (mg/kg bw/day) + 0.0622. Hepato-toxicity was demonstrated based on significant increase in AST and γ-GT activities and the degree of histopathological changes. The lowest BMDL5 of 0.07228 mg BDE-209/kg of liver ww, correlating to external dose of 39 mg/kg/day, indicated the increase of AST activity as the most sensitive biomarker of BDE-209 hepatotoxicity in subacutely ex-posed rats. Conclusion. The results of the present work add up to the issue of BDE-209 toxicity profile with a focus on relationship between internal dose and hepatotoxicity. Critical internal dose for the effect on AST of 0.07 mg/kg of liver ww, corresponding to external dose of 39 mg/kg/day, is the lowest dose ever observed among the studies on BDE-209 hepatotoxicity. For the persistent sub-stances with low absorption rate such as BDE-209, critical effect based on internal dose in majority of cases is considered as more precisely defined than the effect established based on external dose, particularly., Uvod/Cilj. Prema podacima iz brojnih studija na životinjama, dekabromovani difeniletar (BDE-209) najznačajnije toksične efekte ispoljava na jetri, homeostazi hormona štitaste žlezde, reproduktivnom i nervnom sistemu. BDE-209 ispoljava toksične efekte delom preko receptora za aromatične ugljovodonike (Ah) i posledične indukcije mikrozomalnih enzima jetre. Cilj rada bio je procena hepatotoksičnog efekta u odnosu na dozu BDE-209 u ciljnom tkivu kod subakutno oralno eksponovanih Wistar pacova. Metode. Efekti su ispitivani na mužjacima Wistar pacova, mase 200-240 g, koji su putem oralne sonde primali doze od 1 000, 2 000 ili 4 000 mg BDE-209/kg telesne mase (tm) dan, tokom 28 dana. Životinje su tretirane u skladu sa odlukom Etičkog komiteta Vojnomedicinske akademije u Beogradu br. 9667-1/2011. Procena hepatotoksičnih efekata bazirana je na merenju relativne mase jetre, unosa vode i hrane, biohemijskih parametara funkcije jetre [aspartat aminotransferaza (AST), alanin amino-transferaza (ALT), alkalna fosfataza (ALP), gama glutamil transferaza (γ-GT)], parametara oksidativnog stresa u homogenatima jetre [malondialdehid (MDA), superoksid dizmutaza (SOD), -SH)] i morfoloških i histoloških promena na jetri. Za procenu odnosa interna doza - odgovor izračunavana je donja granica pouzdanosti granične Benchmark doze (BMDL) od 5% (BMDL5) ili 10% (BMDL10) primenom PROAST softvera. Rezultati. Koncentracije BDE-209 iznosile su 0,269, 0,569 i 0,859 mg/kg jetre nakon aplikacije 1 000, 2 000, odnosno 4 000 mg BDE-209/kg tm/dan. Interna doza u našoj studiji korelisala je sa eksternom dozom prema jednačini: interna doza (mg BDE-209/kg jetre) = 0,0002 ' eksterna doza (mg/kg tm/dan) + 0,0622 (r = 0,972; p  lt  0,05). Hepatotoksičnost je potvrđena na osnovu nalaza o povećanju aktivnosti enzima AST i γ-GT, kao i stepena patohistološkog oštećenja jetre. Najniža BMDL5 u eksperimentu od 0,07228 mg BDE-209/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan izračunata je za aktivnost AST i ukazuje na to da je aktivnost AST ujedno i najosetljiviji biomarker hepatotoksičnosti BDE-209 kod subakutno eksponovanih pacova. Zaključak. Rezultati prezentovane studije daju doprinos pitanju toksikološkog profila BDE-209 sa fokusom na odnos između interne doze i hepatotoksičnih efekata. Kritična interna doza za efekat na AST od 0,07 mg/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan, jeste ujedno i najniža kritična doza do sada definisana za hepatotoksične efekte BDE-209. Kritičan efekat koji se bazira na dozi u ciljnom tkivu u većini slučajeva može se smatrati preciznije definisanim od kritičnog efekta definisanog na bazi oralno primenjene doze, naročito za nedegradabilne supstance sa niskim stepenom apsorpcije, kao što je BDE-209.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats, Odnos hepatotoksičnosti i doze dekabromovanog difeniletra u ciljnom tkivu kod subakutno izloženih Wistar pacova",
volume = "72",
number = "5",
pages = "405-413",
doi = "10.2298/VSP1505405C"
}

Ćurčić, M., Tanasković, S., Stanković, S., Janković, S., Antunović, M., Đorđević, S., Kilibarda, V., Vučinić, S.,& Antonijević, B.. (2015). Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(5), 405-413.
https://doi.org/10.2298/VSP1505405C

Ćurčić M, Tanasković S, Stanković S, Janković S, Antunović M, Đorđević S, Kilibarda V, Vučinić S, Antonijević B. Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. in Vojnosanitetski pregled. 2015;72(5):405-413.
doi:10.2298/VSP1505405C .

Ćurčić, Marijana, Tanasković, Slađana, Stanković, Sanja, Janković, Saša, Antunović, Marko, Đorđević, Snežana, Kilibarda, Vesna, Vučinić, Slavica, Antonijević, Biljana, "Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats" in Vojnosanitetski pregled, 72, no. 5 (2015):405-413,
https://doi.org/10.2298/VSP1505405C . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Milovanović, V.
AU  - Buha, Aleksandra
AU  - Bulat, Zorica
AU  - Antunović, M.
AU  - Đorđević, S.
AU  - Vučinić, Slavica
AU  - Durgo, Ksenija
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2335
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Interactions between cadmium and decabrominated diphenyl ethers for the effect on lipid peroxidation in brain of Wistar rats
VL  - 238
IS  - 2, Supplement
SP  - S361
EP  - S361
DO  - 10.1016/j.toxlet.2015.08.1029
ER  - 

@conference{
author = "Ćurčić, Marijana and Milovanović, V. and Buha, Aleksandra and Bulat, Zorica and Antunović, M. and Đorđević, S. and Vučinić, Slavica and Durgo, Ksenija and Đukić-Ćosić, Danijela and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Interactions between cadmium and decabrominated diphenyl ethers for the effect on lipid peroxidation in brain of Wistar rats",
volume = "238",
number = "2, Supplement",
pages = "S361-S361",
doi = "10.1016/j.toxlet.2015.08.1029"
}

Ćurčić, M., Milovanović, V., Buha, A., Bulat, Z., Antunović, M., Đorđević, S., Vučinić, S., Durgo, K., Đukić-Ćosić, D.,& Antonijević, B.. (2015). Interactions between cadmium and decabrominated diphenyl ethers for the effect on lipid peroxidation in brain of Wistar rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S361-S361.
https://doi.org/10.1016/j.toxlet.2015.08.1029

Ćurčić M, Milovanović V, Buha A, Bulat Z, Antunović M, Đorđević S, Vučinić S, Durgo K, Đukić-Ćosić D, Antonijević B. Interactions between cadmium and decabrominated diphenyl ethers for the effect on lipid peroxidation in brain of Wistar rats. in Toxicology Letters. 2015;238(2, Supplement):S361-S361.
doi:10.1016/j.toxlet.2015.08.1029 .

Ćurčić, Marijana, Milovanović, V., Buha, Aleksandra, Bulat, Zorica, Antunović, M., Đorđević, S., Vučinić, Slavica, Durgo, Ksenija, Đukić-Ćosić, Danijela, Antonijević, Biljana, "Interactions between cadmium and decabrominated diphenyl ethers for the effect on lipid peroxidation in brain of Wistar rats" in Toxicology Letters, 238, no. 2, Supplement (2015):S361-S361,
https://doi.org/10.1016/j.toxlet.2015.08.1029 . .

TY  - CONF
AU  - Milovanović, V.
AU  - Buha, Aleksandra
AU  - Matović, Vesna
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2372
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Correlation of total and free thyroid hormones in rats after subacute exposure to decabrominated diphenyl ether
VL  - 238
IS  - 2, Supplement
SP  - S266
EP  - S266
DO  - 10.1016/j.toxlet.2015.08.768
ER  - 

@conference{
author = "Milovanović, V. and Buha, Aleksandra and Matović, Vesna and Ćurčić, Marijana and Vučinić, Slavica and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Correlation of total and free thyroid hormones in rats after subacute exposure to decabrominated diphenyl ether",
volume = "238",
number = "2, Supplement",
pages = "S266-S266",
doi = "10.1016/j.toxlet.2015.08.768"
}

Milovanović, V., Buha, A., Matović, V., Ćurčić, M., Vučinić, S.,& Antonijević, B.. (2015). Correlation of total and free thyroid hormones in rats after subacute exposure to decabrominated diphenyl ether. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S266-S266.
https://doi.org/10.1016/j.toxlet.2015.08.768

Milovanović V, Buha A, Matović V, Ćurčić M, Vučinić S, Antonijević B. Correlation of total and free thyroid hormones in rats after subacute exposure to decabrominated diphenyl ether. in Toxicology Letters. 2015;238(2, Supplement):S266-S266.
doi:10.1016/j.toxlet.2015.08.768 .

Milovanović, V., Buha, Aleksandra, Matović, Vesna, Ćurčić, Marijana, Vučinić, Slavica, Antonijević, Biljana, "Correlation of total and free thyroid hormones in rats after subacute exposure to decabrominated diphenyl ether" in Toxicology Letters, 238, no. 2, Supplement (2015):S266-S266,
https://doi.org/10.1016/j.toxlet.2015.08.768 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Nikolić, Dragica
AU  - Bulat, Zorica
AU  - Durgo, Ksenija
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2373
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Benchmark dose for decabrominated diphenyl ether and cadmium effect on Cu increase in liver of Wistar rats
VL  - 238
IS  - 2, Supplement
SP  - S295
EP  - S295
DO  - 10.1016/j.toxlet.2015.08.847
ER  - 

@conference{
author = "Ćurčić, Marijana and Janković, Saša and Nikolić, Dragica and Bulat, Zorica and Durgo, Ksenija and Vučinić, Slavica and Antonijević, Biljana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Benchmark dose for decabrominated diphenyl ether and cadmium effect on Cu increase in liver of Wistar rats",
volume = "238",
number = "2, Supplement",
pages = "S295-S295",
doi = "10.1016/j.toxlet.2015.08.847"
}

Ćurčić, M., Janković, S., Nikolić, D., Bulat, Z., Durgo, K., Vučinić, S.,& Antonijević, B.. (2015). Benchmark dose for decabrominated diphenyl ether and cadmium effect on Cu increase in liver of Wistar rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S295-S295.
https://doi.org/10.1016/j.toxlet.2015.08.847

Ćurčić M, Janković S, Nikolić D, Bulat Z, Durgo K, Vučinić S, Antonijević B. Benchmark dose for decabrominated diphenyl ether and cadmium effect on Cu increase in liver of Wistar rats. in Toxicology Letters. 2015;238(2, Supplement):S295-S295.
doi:10.1016/j.toxlet.2015.08.847 .

Ćurčić, Marijana, Janković, Saša, Nikolić, Dragica, Bulat, Zorica, Durgo, Ksenija, Vučinić, Slavica, Antonijević, Biljana, "Benchmark dose for decabrominated diphenyl ether and cadmium effect on Cu increase in liver of Wistar rats" in Toxicology Letters, 238, no. 2, Supplement (2015):S295-S295,
https://doi.org/10.1016/j.toxlet.2015.08.847 . .

TY  - CONF
AU  - Vučinić, Slavica
AU  - Kilibarda, Vesna
AU  - Jović-Stošić, Jasmina
AU  - Jovanović, M.
AU  - Antonijević, Biljana
AU  - Antonijević, Evica
AU  - Brajković, Gordana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2371
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions
VL  - 238
IS  - 2, Supplement
SP  - S145
EP  - S145
DO  - 10.1016/j.toxlet.2015.08.456
ER  - 

@conference{
author = "Vučinić, Slavica and Kilibarda, Vesna and Jović-Stošić, Jasmina and Jovanović, M. and Antonijević, Biljana and Antonijević, Evica and Brajković, Gordana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions",
volume = "238",
number = "2, Supplement",
pages = "S145-S145",
doi = "10.1016/j.toxlet.2015.08.456"
}

Vučinić, S., Kilibarda, V., Jović-Stošić, J., Jovanović, M., Antonijević, B., Antonijević, E.,& Brajković, G.. (2015). Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S145-S145.
https://doi.org/10.1016/j.toxlet.2015.08.456

Vučinić S, Kilibarda V, Jović-Stošić J, Jovanović M, Antonijević B, Antonijević E, Brajković G. Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions. in Toxicology Letters. 2015;238(2, Supplement):S145-S145.
doi:10.1016/j.toxlet.2015.08.456 .

Vučinić, Slavica, Kilibarda, Vesna, Jović-Stošić, Jasmina, Jovanović, M., Antonijević, Biljana, Antonijević, Evica, Brajković, Gordana, "Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions" in Toxicology Letters, 238, no. 2, Supplement (2015):S145-S145,
https://doi.org/10.1016/j.toxlet.2015.08.456 . .

TY  - CONF
AU  - Milovanović, Vesna
AU  - Buha, Aleksandra
AU  - Ćurčić, Marijana
AU  - Vučinić, Slavica
AU  - Jaćević, Vesna
AU  - Janković, Saša
AU  - Antonijević, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2221
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effects of BDE-209 on peripheral leukocyte counts in subacutely exposed Wistar rats
VL  - 229
IS  - Supplement
SP  - S208
EP  - S209
DO  - 10.1016/j.toxlet.2014.06.702
ER  - 

@conference{
author = "Milovanović, Vesna and Buha, Aleksandra and Ćurčić, Marijana and Vučinić, Slavica and Jaćević, Vesna and Janković, Saša and Antonijević, Biljana",
year = "2014",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effects of BDE-209 on peripheral leukocyte counts in subacutely exposed Wistar rats",
volume = "229",
number = "Supplement",
pages = "S208-S209",
doi = "10.1016/j.toxlet.2014.06.702"
}

Milovanović, V., Buha, A., Ćurčić, M., Vučinić, S., Jaćević, V., Janković, S.,& Antonijević, B.. (2014). The effects of BDE-209 on peripheral leukocyte counts in subacutely exposed Wistar rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 229(Supplement), S208-S209.
https://doi.org/10.1016/j.toxlet.2014.06.702

Milovanović V, Buha A, Ćurčić M, Vučinić S, Jaćević V, Janković S, Antonijević B. The effects of BDE-209 on peripheral leukocyte counts in subacutely exposed Wistar rats. in Toxicology Letters. 2014;229(Supplement):S208-S209.
doi:10.1016/j.toxlet.2014.06.702 .

Milovanović, Vesna, Buha, Aleksandra, Ćurčić, Marijana, Vučinić, Slavica, Jaćević, Vesna, Janković, Saša, Antonijević, Biljana, "The effects of BDE-209 on peripheral leukocyte counts in subacutely exposed Wistar rats" in Toxicology Letters, 229, no. Supplement (2014):S208-S209,
https://doi.org/10.1016/j.toxlet.2014.06.702 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Stanković, Sanja
AU  - Vučinić, Slavica
AU  - Jaćević, Vesna
AU  - Brkić, Dragica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Antonijević, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2219
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effects of Cd and BDE-209 co-exposure on hematological parameters in rats
VL  - 229
IS  - Supplement
SP  - S209
EP  - S209
DO  - 10.1016/j.toxlet.2014.06.704
ER  - 

@conference{
author = "Ćurčić, Marijana and Stanković, Sanja and Vučinić, Slavica and Jaćević, Vesna and Brkić, Dragica and Đukić-Ćosić, Danijela and Antonijević, Evica and Antonijević, Biljana",
year = "2014",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effects of Cd and BDE-209 co-exposure on hematological parameters in rats",
volume = "229",
number = "Supplement",
pages = "S209-S209",
doi = "10.1016/j.toxlet.2014.06.704"
}

Ćurčić, M., Stanković, S., Vučinić, S., Jaćević, V., Brkić, D., Đukić-Ćosić, D., Antonijević, E.,& Antonijević, B.. (2014). The effects of Cd and BDE-209 co-exposure on hematological parameters in rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 229(Supplement), S209-S209.
https://doi.org/10.1016/j.toxlet.2014.06.704

Ćurčić M, Stanković S, Vučinić S, Jaćević V, Brkić D, Đukić-Ćosić D, Antonijević E, Antonijević B. The effects of Cd and BDE-209 co-exposure on hematological parameters in rats. in Toxicology Letters. 2014;229(Supplement):S209-S209.
doi:10.1016/j.toxlet.2014.06.704 .

Ćurčić, Marijana, Stanković, Sanja, Vučinić, Slavica, Jaćević, Vesna, Brkić, Dragica, Đukić-Ćosić, Danijela, Antonijević, Evica, Antonijević, Biljana, "The effects of Cd and BDE-209 co-exposure on hematological parameters in rats" in Toxicology Letters, 229, no. Supplement (2014):S209-S209,
https://doi.org/10.1016/j.toxlet.2014.06.704 . .

TY  - CHAP
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
AU  - Brkić, Dragica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2263
AB  - Besides being a potential risk to humans and other living organisms, organophosphorus (OP) compounds also poses a risk to the environment. Production and placing pesticides on the market are under national and international legislative framework, although in many developing countries the regulation is still inadequate or not properly enforced. Occupational exposure to OPs includes any job which involves either direct or indirect contact with OP compounds, while public exposure to OPs may occur through contaminated food or from hand-to-mouth contact with contaminated surfaces, inhalation and dermal contact. The aim of this chapter is to present a comprehensive review of control and regulation measures, risk assessment methods, types and modality of occupational and environmental exposure to OPs, and ecotoxicology of these compounds. Review of the literature on OP exposure in electronic bibliographic databases, textbooks, and Internet sources was done. The acute high-dose effects of OPs are well known and include neurological dysfunction due to the inhibition of acetylcholinesterase (AChE), while effects of low-level exposure are still a matter of controversy. Advances in analytical methods help scientists to find new biomarkers of exposure and tools for biological monitoring and regulations of occupational exposure.
PB  - Springer-Verlag London Ltd
T2  - Basic and Clinical Toxicology of Organophosphorus Compounds
T1  - Occupational and environmental aspects of organophosphorus compounds
SP  - 213
EP  - 244
DO  - 10.1007/978-1-4471-5625-3_8
ER  - 

@inbook{
author = "Vučinić, Slavica and Antonijević, Biljana and Brkić, Dragica",
year = "2014",
abstract = "Besides being a potential risk to humans and other living organisms, organophosphorus (OP) compounds also poses a risk to the environment. Production and placing pesticides on the market are under national and international legislative framework, although in many developing countries the regulation is still inadequate or not properly enforced. Occupational exposure to OPs includes any job which involves either direct or indirect contact with OP compounds, while public exposure to OPs may occur through contaminated food or from hand-to-mouth contact with contaminated surfaces, inhalation and dermal contact. The aim of this chapter is to present a comprehensive review of control and regulation measures, risk assessment methods, types and modality of occupational and environmental exposure to OPs, and ecotoxicology of these compounds. Review of the literature on OP exposure in electronic bibliographic databases, textbooks, and Internet sources was done. The acute high-dose effects of OPs are well known and include neurological dysfunction due to the inhibition of acetylcholinesterase (AChE), while effects of low-level exposure are still a matter of controversy. Advances in analytical methods help scientists to find new biomarkers of exposure and tools for biological monitoring and regulations of occupational exposure.",
publisher = "Springer-Verlag London Ltd",
journal = "Basic and Clinical Toxicology of Organophosphorus Compounds",
booktitle = "Occupational and environmental aspects of organophosphorus compounds",
pages = "213-244",
doi = "10.1007/978-1-4471-5625-3_8"
}

Vučinić, S., Antonijević, B.,& Brkić, D.. (2014). Occupational and environmental aspects of organophosphorus compounds. in Basic and Clinical Toxicology of Organophosphorus Compounds
Springer-Verlag London Ltd., 213-244.
https://doi.org/10.1007/978-1-4471-5625-3_8

Vučinić S, Antonijević B, Brkić D. Occupational and environmental aspects of organophosphorus compounds. in Basic and Clinical Toxicology of Organophosphorus Compounds. 2014;:213-244.
doi:10.1007/978-1-4471-5625-3_8 .

Vučinić, Slavica, Antonijević, Biljana, Brkić, Dragica, "Occupational and environmental aspects of organophosphorus compounds" in Basic and Clinical Toxicology of Organophosphorus Compounds (2014):213-244,
https://doi.org/10.1007/978-1-4471-5625-3_8 . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Durgo, Ksenija
AU  - Kopjar, Nevenka
AU  - Ancić, Mario
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2128
AB  - In order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water. Cells were treated with single Cd in concentrations of 2.5, 7.5 or 15 mu g Cd/mL (corresponding to 22, 67 or 134 mu M), single BDE-209 in concentrations of 2.5, 5 or 10 mu g BDE209/mL (corresponding to 2.5, 5 or 10 mu M), and their mixtures (design 3 x 3). Mixture of Cd and BDE-209 has shown clear potential to reduce the viability of SW 480 cells, as evidenced by cytotoxicity associated with ROS generation. Factorial regression models used to identify type of interaction revealed synergism related to mixture citotoxicity and additive interaction for the effect on ROS production. The results from this introductory study could contribute to the issue of possible adverse effects associated with co-exposure and body burden with two persistent environmental pollutants, Cd and BDE-209.
PB  - Elsevier Science BV, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects
VL  - 38
IS  - 2
SP  - 663
EP  - 671
DO  - 10.1016/j.etap.2014.07.021
ER  - 

@article{
author = "Ćurčić, Marijana and Durgo, Ksenija and Kopjar, Nevenka and Ancić, Mario and Vučinić, Slavica and Antonijević, Biljana",
year = "2014",
abstract = "In order to look into the combined effects of Cd and BDE-209 in vitro, this study was aimed at examining cytotoxic and genotoxic effects using the human colon carcinoma cell line (SW 480) as a biological test system as well as to determine if ROS production was one of the possible mechanisms of their mixture action. This cell line was chosen since ingestion of contaminated food/water represents an important route of exposure to both Cd and BDE-209, which is why intestinal cells are a common target for the contaminants present in food and water. Cells were treated with single Cd in concentrations of 2.5, 7.5 or 15 mu g Cd/mL (corresponding to 22, 67 or 134 mu M), single BDE-209 in concentrations of 2.5, 5 or 10 mu g BDE209/mL (corresponding to 2.5, 5 or 10 mu M), and their mixtures (design 3 x 3). Mixture of Cd and BDE-209 has shown clear potential to reduce the viability of SW 480 cells, as evidenced by cytotoxicity associated with ROS generation. Factorial regression models used to identify type of interaction revealed synergism related to mixture citotoxicity and additive interaction for the effect on ROS production. The results from this introductory study could contribute to the issue of possible adverse effects associated with co-exposure and body burden with two persistent environmental pollutants, Cd and BDE-209.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects",
volume = "38",
number = "2",
pages = "663-671",
doi = "10.1016/j.etap.2014.07.021"
}

Ćurčić, M., Durgo, K., Kopjar, N., Ancić, M., Vučinić, S.,& Antonijević, B.. (2014). Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects. in Environmental Toxicology and Pharmacology
Elsevier Science BV, Amsterdam., 38(2), 663-671.
https://doi.org/10.1016/j.etap.2014.07.021

Ćurčić M, Durgo K, Kopjar N, Ancić M, Vučinić S, Antonijević B. Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects. in Environmental Toxicology and Pharmacology. 2014;38(2):663-671.
doi:10.1016/j.etap.2014.07.021 .

Ćurčić, Marijana, Durgo, Ksenija, Kopjar, Nevenka, Ancić, Mario, Vučinić, Slavica, Antonijević, Biljana, "Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects" in Environmental Toxicology and Pharmacology, 38, no. 2 (2014):663-671,
https://doi.org/10.1016/j.etap.2014.07.021 . .