TY  - JOUR
AU  - Pijanović, Marina
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Marić-Krejović, Snežana
AU  - Spasić, Slavica
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2986
AB  - Background: Leptin and adiponectin play an important role during normal gestation; they are implicated in energy metabolism, glucose utilization and inflammation. Osteocalcin is released into circulation during bone formation; it also affects glucose metabolism by regulating insulin secretion and sensitivity, possibly mediated by adiponectin. The aim of this study was to explore the longitudinal changes of leptin and adiponectin in pregnancy, and their associations with lipid profile, insulin and bone formation parameters in late pregnancy. Methods: Leptin, adiponectin, lipid status parameters, C-reactive protein (CRP), insulin, 25-hydroxyvitamin D, osteocalcin and procollagen type 1 aminoterminal propeptide (P1NP) were measured in the sera of 38 healthy pregnant women. The samples were obtained in the 1st , 2nd, early and late 3rd, trimester, and post-partum. Results: Leptin was significantly increased in the 3rd trimester. The decrease of adiponectin was significant only in postpartum. Osteocalcin and P1NP increased in the late 3rd trimester and postpartum. Leptin was significantly positively correlated with body mass index (BMI), uric acid, insulin, osteocalcin, P1NP and CRP in the 3rd trimester; adiponectin was positively correlated with highdensity lipoprotein (HDL) cholesterol, and negatively with BMI, glucose, osteocalcin, triglycerides and insulin. Multiple regression analysis showed that only HDL is independently associated with adiponectin. Conclusions: The results of our study suggest complex interactions of leptin and adiponectin with glucose, lipid and bone metabolism during pregnancy. Adiponectin might be part of the protective systems that counterbalance a transient proatherogenic state observed in pregnancy mainly by improving the HDL levels. The exact mechanisms and potential implications in pathological states of pregnancy remain unexplained and require further investigation.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Laboratoriumsmedizin-Journal of Laboratory Medicine
T1  - Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy
VL  - 41
IS  - 3
SP  - 129
EP  - 136
DO  - 10.1515/labmed-2017-0052
ER  - 

@article{
author = "Pijanović, Marina and Stefanović, Aleksandra and Miljković, Milica and Marić-Krejović, Snežana and Spasić, Slavica",
year = "2017",
abstract = "Background: Leptin and adiponectin play an important role during normal gestation; they are implicated in energy metabolism, glucose utilization and inflammation. Osteocalcin is released into circulation during bone formation; it also affects glucose metabolism by regulating insulin secretion and sensitivity, possibly mediated by adiponectin. The aim of this study was to explore the longitudinal changes of leptin and adiponectin in pregnancy, and their associations with lipid profile, insulin and bone formation parameters in late pregnancy. Methods: Leptin, adiponectin, lipid status parameters, C-reactive protein (CRP), insulin, 25-hydroxyvitamin D, osteocalcin and procollagen type 1 aminoterminal propeptide (P1NP) were measured in the sera of 38 healthy pregnant women. The samples were obtained in the 1st , 2nd, early and late 3rd, trimester, and post-partum. Results: Leptin was significantly increased in the 3rd trimester. The decrease of adiponectin was significant only in postpartum. Osteocalcin and P1NP increased in the late 3rd trimester and postpartum. Leptin was significantly positively correlated with body mass index (BMI), uric acid, insulin, osteocalcin, P1NP and CRP in the 3rd trimester; adiponectin was positively correlated with highdensity lipoprotein (HDL) cholesterol, and negatively with BMI, glucose, osteocalcin, triglycerides and insulin. Multiple regression analysis showed that only HDL is independently associated with adiponectin. Conclusions: The results of our study suggest complex interactions of leptin and adiponectin with glucose, lipid and bone metabolism during pregnancy. Adiponectin might be part of the protective systems that counterbalance a transient proatherogenic state observed in pregnancy mainly by improving the HDL levels. The exact mechanisms and potential implications in pathological states of pregnancy remain unexplained and require further investigation.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Laboratoriumsmedizin-Journal of Laboratory Medicine",
title = "Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy",
volume = "41",
number = "3",
pages = "129-136",
doi = "10.1515/labmed-2017-0052"
}

Pijanović, M., Stefanović, A., Miljković, M., Marić-Krejović, S.,& Spasić, S.. (2017). Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 41(3), 129-136.
https://doi.org/10.1515/labmed-2017-0052

Pijanović M, Stefanović A, Miljković M, Marić-Krejović S, Spasić S. Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine. 2017;41(3):129-136.
doi:10.1515/labmed-2017-0052 .

Pijanović, Marina, Stefanović, Aleksandra, Miljković, Milica, Marić-Krejović, Snežana, Spasić, Slavica, "Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy" in Laboratoriumsmedizin-Journal of Laboratory Medicine, 41, no. 3 (2017):129-136,
https://doi.org/10.1515/labmed-2017-0052 . .

TY  - JOUR
AU  - Pijanović, Marina
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Marić-Krejović, Snežana
AU  - Spasić, Slavica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2717
AB  - Background: The aim of this study was to explore longitudinal changes of serum osteocalcin during normal, uncomplicated pregnancy and after delivery, and its correlations with parameters of glucose homeostasis, lipid status, and oxidative status in late pregnancy. Methods: Osteocalcin, glucose, insulin, lipid status parameters, total oxidative status (TOS), and total antioxidant capacity (TAC) were measured in sera of 38 healthy pregnant women. The sera were collected at the midpoint of the 1st, in the 2nd and 3rd trimester, and after delivery. Homeostatic model assessment (HOMA) indices were calculated and used as surrogate markers of insulin resistance. Results: Repeated measures analysis of variance showed a progressive increase in total cholesterol, triglycerides, and low density lipoprotein (LDL)-cholesterol, with a postpartum decrease. High density lipoprotein (HDL)-cholesterol increased in the 2nd trimester and decreased after delivery. Total oxidative status (TOS) increased significantly in the 3rd trimester (p  lt  0.001). TAC showed a significant increase after delivery (p  lt  0.05). Insulin showed a significant increase in the 3rd trimester (p  lt  0.05). Homeostatic model assessment (HOMA)-%B increased significantly in the 3rd trimester (p  lt  0.001). Osteocalcin showed a decrease in the 2nd trimester, and a marked increase in the 3rd - trimester and postpartum (p  lt  0.001). Osteocalcin was significantly positively correlated with BMI, insulin, HOMA of insulin resistance (HOMA-IR), HOMA-%B, TAC (p  lt  0.05), triglycerides and uric acid (p  lt  0.001). Multiple regression analysis showed that TAC is independently associated with osteocalcin level during 3rd trimester (p  lt  0.05). Conclusions: We observed the changes in pregnancy that may lead towards atherogenic, prooxidant and insulin resistant state, which are possibly counterbalanced by various protective systems, one of which might be osteocalcin.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Laboratoriumsmedizin-Journal of Laboratory Medicine
T1  - Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy
VL  - 40
IS  - 4
SP  - 247
EP  - 253
DO  - 10.1515/labmed-2016-0024
ER  - 

@article{
author = "Pijanović, Marina and Stefanović, Aleksandra and Miljković, Milica and Marić-Krejović, Snežana and Spasić, Slavica",
year = "2016",
abstract = "Background: The aim of this study was to explore longitudinal changes of serum osteocalcin during normal, uncomplicated pregnancy and after delivery, and its correlations with parameters of glucose homeostasis, lipid status, and oxidative status in late pregnancy. Methods: Osteocalcin, glucose, insulin, lipid status parameters, total oxidative status (TOS), and total antioxidant capacity (TAC) were measured in sera of 38 healthy pregnant women. The sera were collected at the midpoint of the 1st, in the 2nd and 3rd trimester, and after delivery. Homeostatic model assessment (HOMA) indices were calculated and used as surrogate markers of insulin resistance. Results: Repeated measures analysis of variance showed a progressive increase in total cholesterol, triglycerides, and low density lipoprotein (LDL)-cholesterol, with a postpartum decrease. High density lipoprotein (HDL)-cholesterol increased in the 2nd trimester and decreased after delivery. Total oxidative status (TOS) increased significantly in the 3rd trimester (p  lt  0.001). TAC showed a significant increase after delivery (p  lt  0.05). Insulin showed a significant increase in the 3rd trimester (p  lt  0.05). Homeostatic model assessment (HOMA)-%B increased significantly in the 3rd trimester (p  lt  0.001). Osteocalcin showed a decrease in the 2nd trimester, and a marked increase in the 3rd - trimester and postpartum (p  lt  0.001). Osteocalcin was significantly positively correlated with BMI, insulin, HOMA of insulin resistance (HOMA-IR), HOMA-%B, TAC (p  lt  0.05), triglycerides and uric acid (p  lt  0.001). Multiple regression analysis showed that TAC is independently associated with osteocalcin level during 3rd trimester (p  lt  0.05). Conclusions: We observed the changes in pregnancy that may lead towards atherogenic, prooxidant and insulin resistant state, which are possibly counterbalanced by various protective systems, one of which might be osteocalcin.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Laboratoriumsmedizin-Journal of Laboratory Medicine",
title = "Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy",
volume = "40",
number = "4",
pages = "247-253",
doi = "10.1515/labmed-2016-0024"
}

Pijanović, M., Stefanović, A., Miljković, M., Marić-Krejović, S.,& Spasić, S.. (2016). Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 40(4), 247-253.
https://doi.org/10.1515/labmed-2016-0024

Pijanović M, Stefanović A, Miljković M, Marić-Krejović S, Spasić S. Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine. 2016;40(4):247-253.
doi:10.1515/labmed-2016-0024 .

Pijanović, Marina, Stefanović, Aleksandra, Miljković, Milica, Marić-Krejović, Snežana, Spasić, Slavica, "Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy" in Laboratoriumsmedizin-Journal of Laboratory Medicine, 40, no. 4 (2016):247-253,
https://doi.org/10.1515/labmed-2016-0024 . .