TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Savić, V.
AU  - Prokić, Vera
AU  - Stojanov, Marina
AU  - Černak, Ibolja
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/660
AB  - Lung trauma has been considered to be one of the vital injuries induced by explosion-generated blast overpressure. Conflicting evidence exists as to whether nitric oxide plays a crucial role in acute lung injury induced by blast. Data presented in this study demonstrate that local exposure of midthoracic region to moderate-level blast overpressure significantly enhanced lipid peroxidation product malondialdehyde and superoxide anion generation in rabbit's lungs 30 minutes after exposure, whereas the activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) activity showed parallel increase. NG-nitro-L-arginine methyl ester, a non-specific inhibitor of nitric oxide synthase (NOS), had no effects on the measured parameters suggesting that oxidative stress induced by blast exposure might be independent from NOS.
AB  - Smatra se da je povreda pluća jedna od najvažnijih povreda do kojih dolazi delovanjem blast talasa generisanog na mestu eksplozije. Do danas ne postoji definitivan stav da li azot-monoksid ima bitnu ulogu u akutnoj blast povredi pluća. Rezultati ove studije pokazuju da lokalno delovanje blast nadpritiska srednje jačine na središnji deo toraksa dovodi do povećanog stvaranja malondialdehida, produkta lipidne peroksidacije kao i povećanog generisanja superoksidnog anjona, 30 minuta posle traume. Istovremeno, dolazi do smanjenja aktivnosti antioksidativnih enzima (superoksid-dizmutaze i glutation-peroksidaze) u plućnom tkivu kunića. NG-nitro-L-arginin-metil estar (L-NAME), nespecifični inhibitor enzima azot-monoksid sintaze (NOS) nije imao efekta na određivane parametere, što ukazuje daje oskidativni stres indukovan blast povredom verovatno nezavisan od aktivnosti enzima NOS.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production
T1  - Oksidativni stres u akutnoj blast povredi pluća je nezavisan od enzimske sinteze azot-monoksida
VL  - 55
IS  - 5-6
SP  - 385
EP  - 394
DO  - 10.2298/AVB0506385K
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Savić, V. and Prokić, Vera and Stojanov, Marina and Černak, Ibolja",
year = "2005",
abstract = "Lung trauma has been considered to be one of the vital injuries induced by explosion-generated blast overpressure. Conflicting evidence exists as to whether nitric oxide plays a crucial role in acute lung injury induced by blast. Data presented in this study demonstrate that local exposure of midthoracic region to moderate-level blast overpressure significantly enhanced lipid peroxidation product malondialdehyde and superoxide anion generation in rabbit's lungs 30 minutes after exposure, whereas the activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) activity showed parallel increase. NG-nitro-L-arginine methyl ester, a non-specific inhibitor of nitric oxide synthase (NOS), had no effects on the measured parameters suggesting that oxidative stress induced by blast exposure might be independent from NOS., Smatra se da je povreda pluća jedna od najvažnijih povreda do kojih dolazi delovanjem blast talasa generisanog na mestu eksplozije. Do danas ne postoji definitivan stav da li azot-monoksid ima bitnu ulogu u akutnoj blast povredi pluća. Rezultati ove studije pokazuju da lokalno delovanje blast nadpritiska srednje jačine na središnji deo toraksa dovodi do povećanog stvaranja malondialdehida, produkta lipidne peroksidacije kao i povećanog generisanja superoksidnog anjona, 30 minuta posle traume. Istovremeno, dolazi do smanjenja aktivnosti antioksidativnih enzima (superoksid-dizmutaze i glutation-peroksidaze) u plućnom tkivu kunića. NG-nitro-L-arginin-metil estar (L-NAME), nespecifični inhibitor enzima azot-monoksid sintaze (NOS) nije imao efekta na određivane parametere, što ukazuje daje oskidativni stres indukovan blast povredom verovatno nezavisan od aktivnosti enzima NOS.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production, Oksidativni stres u akutnoj blast povredi pluća je nezavisan od enzimske sinteze azot-monoksida",
volume = "55",
number = "5-6",
pages = "385-394",
doi = "10.2298/AVB0506385K"
}

Kotur-Stevuljević, J., Savić, V., Prokić, V., Stojanov, M.,& Černak, I.. (2005). Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 55(5-6), 385-394.
https://doi.org/10.2298/AVB0506385K

Kotur-Stevuljević J, Savić V, Prokić V, Stojanov M, Černak I. Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production. in Acta veterinaria. 2005;55(5-6):385-394.
doi:10.2298/AVB0506385K .

Kotur-Stevuljević, Jelena, Savić, V., Prokić, Vera, Stojanov, Marina, Černak, Ibolja, "Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production" in Acta veterinaria, 55, no. 5-6 (2005):385-394,
https://doi.org/10.2298/AVB0506385K . .