@article{
author = "Drašković, Milica and Turković, Erna and Vasiljević, Ivana and Trifković, Kata and Cvijić, Sandra and Vasiljević, Dragana and Parojčić, Jelena",
year = "2020",
abstract = "Introduction:
Orally disintegrating films (ODFs) are defined as “single- or multi- layer sheets of suitable materials intended to be placed in the mouth where they disperse rapidly” [1]. Considering fast disintegration, ODFs might be used as preferable solid dosage form for patients suffering from dysphagia, particularly, paediatric and geriatric patient popula- tions. High flexibility of drug dose might be achieved by selection of size and/or number of concurrently administered films. However, the main limitation of ODFs is relatively small and restricted amount of drug which can be incorporated [2,3]. In accordance with the Quality by Design approach in pharmaceutical development, it is important to define critical quality attributes (CQAs) of a drug product and under- stand, explain and estimate impact of different formulation factors and process parameters on the final product quality [4]. Borges and co- workers reported, after comprehensive evaluation of various commer- cially available ODFs, that critical quality attributes for orodispersible films development are residual water content, disintegration time and mechanical properties including tensile stress at break/breaking force, tensile strain and Young's modulus [5]. It is of the utmost importance during ODF formulation development to achieve optimal mechanical resistance and fast disintegration, accompanied with the desired drug release profile, in order to provide appropriate product manipulation and administration, facilitated swallowing and targeted bio- performance. ...",
publisher = "Elsevier",
journal = "Journal of Drug Delivery Science and Technology",
title = "Comprehensive evaluation of formulation factors affecting critical quality attributes of casted orally disintegrating films",
volume = "56",
doi = "10.1016/j.jddst.2020.101614"
}
