TY  - JOUR
AU  - Milojević, Z
AU  - Agbaba, Danica
AU  - Erić, Slavica
AU  - Boberić-Borojević, D
AU  - Ristić, P
AU  - Solujić, M
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/325
AB  - A rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of dexamethasone sodium phosphate (DSP), xylometazoline hydrochloride (XMC) and methyl p-hydroxybenzoate (MHB). An assay of the compounds has been performed on a HPLC system GBC 1210, at controlled room temperature, on a Nucleosil C-8 column (250x3 mm, 5 mum). The mobile phase was acetonitrile-water (35:65, v/v), at a flow-rate of 1 ml min(-1). The parameters for validation such as linearity (r>0.9996), precision (RSD: 0.51-(1.93%), limit of detection and quantification (2.032(.)10(-4) and 4.063(.)10(-4) mg ml(-1) for DSP, 9.7(.)10(-5) and 1.953(.)10(-4) mg ml(-1) for XMC, 1.953(.)10(-4) and 3.096(.)10(-4) mg ml(-1) for MHB) have also been reported. The method was applied to the determination of DSP, XMC and MHB in nasal drops. The statistical parameters were found to be satisfactory, with recovery values ranging froth 98.69 to 101.60% (RSD: 0.32-1.03%). The method is simple and accurate and therefore suitable for the simultaneous determination of these compounds in dosage form.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography A
T1  - High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate
VL  - 949
IS  - 1-2
SP  - 79
EP  - 82
DO  - 10.1016/S0021-9673(01)01510-2
ER  - 

@article{
author = "Milojević, Z and Agbaba, Danica and Erić, Slavica and Boberić-Borojević, D and Ristić, P and Solujić, M",
year = "2002",
abstract = "A rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of dexamethasone sodium phosphate (DSP), xylometazoline hydrochloride (XMC) and methyl p-hydroxybenzoate (MHB). An assay of the compounds has been performed on a HPLC system GBC 1210, at controlled room temperature, on a Nucleosil C-8 column (250x3 mm, 5 mum). The mobile phase was acetonitrile-water (35:65, v/v), at a flow-rate of 1 ml min(-1). The parameters for validation such as linearity (r>0.9996), precision (RSD: 0.51-(1.93%), limit of detection and quantification (2.032(.)10(-4) and 4.063(.)10(-4) mg ml(-1) for DSP, 9.7(.)10(-5) and 1.953(.)10(-4) mg ml(-1) for XMC, 1.953(.)10(-4) and 3.096(.)10(-4) mg ml(-1) for MHB) have also been reported. The method was applied to the determination of DSP, XMC and MHB in nasal drops. The statistical parameters were found to be satisfactory, with recovery values ranging froth 98.69 to 101.60% (RSD: 0.32-1.03%). The method is simple and accurate and therefore suitable for the simultaneous determination of these compounds in dosage form.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography A",
title = "High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate",
volume = "949",
number = "1-2",
pages = "79-82",
doi = "10.1016/S0021-9673(01)01510-2"
}

Milojević, Z., Agbaba, D., Erić, S., Boberić-Borojević, D., Ristić, P.,& Solujić, M.. (2002). High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate. in Journal of Chromatography A
Elsevier Science BV, Amsterdam., 949(1-2), 79-82.
https://doi.org/10.1016/S0021-9673(01)01510-2

Milojević Z, Agbaba D, Erić S, Boberić-Borojević D, Ristić P, Solujić M. High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate. in Journal of Chromatography A. 2002;949(1-2):79-82.
doi:10.1016/S0021-9673(01)01510-2 .

Milojević, Z, Agbaba, Danica, Erić, Slavica, Boberić-Borojević, D, Ristić, P, Solujić, M, "High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate" in Journal of Chromatography A, 949, no. 1-2 (2002):79-82,
https://doi.org/10.1016/S0021-9673(01)01510-2 . .

TY  - JOUR
AU  - Agbaba, Danica
AU  - Milojević, Z
AU  - Erić, Slavica
AU  - Aleksić, Mirjana
AU  - Marković, G
AU  - Solujić, M
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/298
AB  - A simple and reliable HPTLC method has been developed and validated for the determination of dexamethasone (as the sodium phosphate salt) and xylometazoline (as the chloride). Assay of the compounds was performed on silica gel HPTLC plates with spherical particles by development with the mobile phase ethyl acetate-acetonitrile-diethylamine-water, 3 + 3 + 1 + 1 (v/v). A TLC scanner set at lambda = 240 nm was used for direct evaluation of chromatograms in reflectance/absorbance mode. The validation data linearity (R > 0.996), precision (RSD = 1.67-2.77%), accuracy (recovery = 95.95-100.69%) and LOD and LOQ (ng levels) were determined and found to be satisfactory. Assay of dexamethasone and xylometazoline in nasal drops was performed simultaneously with assay of preservatives such as methyl para-hydroxybenzoate. The effect of the most commonly used preservative, benzalkonium chloride on the concentrations of active substances was investigated; it was found that this compound led to a significant reduction of the dexamethasone sodium phosphate content of nasal drops.
PB  - Springer Nature
T2  - Journal of Planar Chromatography - Modern TLC
T1  - The high-performance thin-layer chromatographic determination of dexamethasone and xylometazoline in nasal drops containing different preservatives
VL  - 14
IS  - 5
SP  - 322
EP  - 325
DO  - 10.1556/JPC.14.2001.5.3
UR  - https://hdl.handle.net/21.15107/rcub_farfar_298
ER  - 

@article{
author = "Agbaba, Danica and Milojević, Z and Erić, Slavica and Aleksić, Mirjana and Marković, G and Solujić, M",
year = "2001",
abstract = "A simple and reliable HPTLC method has been developed and validated for the determination of dexamethasone (as the sodium phosphate salt) and xylometazoline (as the chloride). Assay of the compounds was performed on silica gel HPTLC plates with spherical particles by development with the mobile phase ethyl acetate-acetonitrile-diethylamine-water, 3 + 3 + 1 + 1 (v/v). A TLC scanner set at lambda = 240 nm was used for direct evaluation of chromatograms in reflectance/absorbance mode. The validation data linearity (R > 0.996), precision (RSD = 1.67-2.77%), accuracy (recovery = 95.95-100.69%) and LOD and LOQ (ng levels) were determined and found to be satisfactory. Assay of dexamethasone and xylometazoline in nasal drops was performed simultaneously with assay of preservatives such as methyl para-hydroxybenzoate. The effect of the most commonly used preservative, benzalkonium chloride on the concentrations of active substances was investigated; it was found that this compound led to a significant reduction of the dexamethasone sodium phosphate content of nasal drops.",
publisher = "Springer Nature",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "The high-performance thin-layer chromatographic determination of dexamethasone and xylometazoline in nasal drops containing different preservatives",
volume = "14",
number = "5",
pages = "322-325",
doi = "10.1556/JPC.14.2001.5.3",
url = "https://hdl.handle.net/21.15107/rcub_farfar_298"
}

Agbaba, D., Milojević, Z., Erić, S., Aleksić, M., Marković, G.,& Solujić, M.. (2001). The high-performance thin-layer chromatographic determination of dexamethasone and xylometazoline in nasal drops containing different preservatives. in Journal of Planar Chromatography - Modern TLC
Springer Nature., 14(5), 322-325.
https://doi.org/10.1556/JPC.14.2001.5.3
https://hdl.handle.net/21.15107/rcub_farfar_298

Agbaba D, Milojević Z, Erić S, Aleksić M, Marković G, Solujić M. The high-performance thin-layer chromatographic determination of dexamethasone and xylometazoline in nasal drops containing different preservatives. in Journal of Planar Chromatography - Modern TLC. 2001;14(5):322-325.
doi:10.1556/JPC.14.2001.5.3
https://hdl.handle.net/21.15107/rcub_farfar_298 .

Agbaba, Danica, Milojević, Z, Erić, Slavica, Aleksić, Mirjana, Marković, G, Solujić, M, "The high-performance thin-layer chromatographic determination of dexamethasone and xylometazoline in nasal drops containing different preservatives" in Journal of Planar Chromatography - Modern TLC, 14, no. 5 (2001):322-325,
https://doi.org/10.1556/JPC.14.2001.5.3 .,
https://hdl.handle.net/21.15107/rcub_farfar_298 .