TY  - JOUR
AU  - Pejić, Nataša
AU  - Blagojević, Slavica
AU  - Anić, Slobodan
AU  - Vukojević, Vladana
AU  - Mijatović, Miroslav D.
AU  - Ćirić, Jasna S.
AU  - Marković, Zoran S.
AU  - Marković, Svetlana D.
AU  - Kolar-Anić, Ljiljana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/942
AB  - A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.
PB  - Elsevier Science BV, Amsterdam
T2  - Analytica Chimica Acta
T1  - Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique
VL  - 582
IS  - 2
SP  - 367
EP  - 374
DO  - 10.1016/j.aca.2006.09.026
ER  - 

@article{
author = "Pejić, Nataša and Blagojević, Slavica and Anić, Slobodan and Vukojević, Vladana and Mijatović, Miroslav D. and Ćirić, Jasna S. and Marković, Zoran S. and Marković, Svetlana D. and Kolar-Anić, Ljiljana",
year = "2007",
abstract = "A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Analytica Chimica Acta",
title = "Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique",
volume = "582",
number = "2",
pages = "367-374",
doi = "10.1016/j.aca.2006.09.026"
}

Pejić, N., Blagojević, S., Anić, S., Vukojević, V., Mijatović, M. D., Ćirić, J. S., Marković, Z. S., Marković, S. D.,& Kolar-Anić, L.. (2007). Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique. in Analytica Chimica Acta
Elsevier Science BV, Amsterdam., 582(2), 367-374.
https://doi.org/10.1016/j.aca.2006.09.026

Pejić N, Blagojević S, Anić S, Vukojević V, Mijatović MD, Ćirić JS, Marković ZS, Marković SD, Kolar-Anić L. Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique. in Analytica Chimica Acta. 2007;582(2):367-374.
doi:10.1016/j.aca.2006.09.026 .

Pejić, Nataša, Blagojević, Slavica, Anić, Slobodan, Vukojević, Vladana, Mijatović, Miroslav D., Ćirić, Jasna S., Marković, Zoran S., Marković, Svetlana D., Kolar-Anić, Ljiljana, "Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique" in Analytica Chimica Acta, 582, no. 2 (2007):367-374,
https://doi.org/10.1016/j.aca.2006.09.026 . .