TY  - JOUR
AU  - Stojić-Vukanić, Zorica
AU  - Hadžibegović, Senka
AU  - Nicole, Olivier
AU  - Nacka-Aleksić, Mirjana
AU  - Leštarević, Sanja
AU  - Leposavić, Gordana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3750
AB  - Neurocognitive impairment (NCI) is one of the most relevant clinical manifestations of multiple sclerosis (MS). The profile of NCI and the structural and functional changes in the brain structures relevant for cognition in MS share some similarities to those in Alzheimer's disease (AD), the most common cause of neurocognitive disorders. Additionally, despite clear etiopathological differences between MS and AD, an accumulation of effector/memory CD8+ T cells and CD8+ tissue-resident memory T (Trm) cells in cognitively relevant brain structures of MS/AD patients, and higher frequency of effector/memory CD8+ T cells re-expressing CD45RA (TEMRA) with high capacity to secrete cytotoxic molecules and proinflammatory cytokines in their blood, were found. Thus, an active pathogenetic role of CD8+ T cells in the progression of MS and AD may be assumed. In this mini-review, findings supporting the putative role of CD8+ T cells in the pathogenesis of MS and AD are displayed, and putative mechanisms underlying their pathogenetic action are discussed. A special effort was made to identify the gaps in the current knowledge about the role of CD8+ T cells in the development of NCI to “catalyze” translational research leading to new feasible therapeutic interventions.
PB  - Frontiers Media S.A.
T2  - Frontiers in Immunology
T1  - CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?
VL  - 11
DO  - 10.3389/fimmu.2020.566225
ER  - 

@article{
author = "Stojić-Vukanić, Zorica and Hadžibegović, Senka and Nicole, Olivier and Nacka-Aleksić, Mirjana and Leštarević, Sanja and Leposavić, Gordana",
year = "2020",
abstract = "Neurocognitive impairment (NCI) is one of the most relevant clinical manifestations of multiple sclerosis (MS). The profile of NCI and the structural and functional changes in the brain structures relevant for cognition in MS share some similarities to those in Alzheimer's disease (AD), the most common cause of neurocognitive disorders. Additionally, despite clear etiopathological differences between MS and AD, an accumulation of effector/memory CD8+ T cells and CD8+ tissue-resident memory T (Trm) cells in cognitively relevant brain structures of MS/AD patients, and higher frequency of effector/memory CD8+ T cells re-expressing CD45RA (TEMRA) with high capacity to secrete cytotoxic molecules and proinflammatory cytokines in their blood, were found. Thus, an active pathogenetic role of CD8+ T cells in the progression of MS and AD may be assumed. In this mini-review, findings supporting the putative role of CD8+ T cells in the pathogenesis of MS and AD are displayed, and putative mechanisms underlying their pathogenetic action are discussed. A special effort was made to identify the gaps in the current knowledge about the role of CD8+ T cells in the development of NCI to “catalyze” translational research leading to new feasible therapeutic interventions.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Immunology",
title = "CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?",
volume = "11",
doi = "10.3389/fimmu.2020.566225"
}

Stojić-Vukanić, Z., Hadžibegović, S., Nicole, O., Nacka-Aleksić, M., Leštarević, S.,& Leposavić, G.. (2020). CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?. in Frontiers in Immunology
Frontiers Media S.A.., 11.
https://doi.org/10.3389/fimmu.2020.566225

Stojić-Vukanić Z, Hadžibegović S, Nicole O, Nacka-Aleksić M, Leštarević S, Leposavić G. CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?. in Frontiers in Immunology. 2020;11.
doi:10.3389/fimmu.2020.566225 .

Stojić-Vukanić, Zorica, Hadžibegović, Senka, Nicole, Olivier, Nacka-Aleksić, Mirjana, Leštarević, Sanja, Leposavić, Gordana, "CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?" in Frontiers in Immunology, 11 (2020),
https://doi.org/10.3389/fimmu.2020.566225 . .

TY  - JOUR
AU  - Ilić, Katarina
AU  - Hadžibegović, Senka
AU  - Đorđević, Brižita
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1592
AB  - Oxidative stress, which develops due to imbalance of free radicals and antioxidant factors, has an important role in oxidative stress. The combination of different antioxidants can act sinergistically in the neutralization of free radicals, nitric oxide increase, improvement of vasodilatation and lowering blood pressure. This paper reviews the impact of certain food ingredients (vitamins, oligoelements, proteins) on prevention of hypertension and blood pressure lowering. Literature was found by searching the Medline database from 1995 to 2010 by using the following keywords: hypertension, prevention of hypertension, antioxidants, electrolytes, and nutrients. Excesive natrium intake as well as insufficiency of microelements in nutrition such as calcium, magnesium, zink and selenium contributes to the development of hypertension. A numerous nutritients used in prevention and treatment of hypertension (hydrolisates of soy proteins, whey, sardines, wheat germs, ω-3 and ω-6 unsaturated fatty acids, green and black tea, mushrooms, vitamin B6, L-arginine, flavonoids, taurine, allicin from garlic, active principles of hawtorn) have effects similar to certain groups of antihipertensive drugs (diuretics, beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptors blockers, central α-agonists, direct vasodilatators). Natural components are of importance in the prevention of hypertension but their potency is not sufficient to lower high blood pressure. However, certain individual components of natural food in combination with antihypertensive drugs may act synergistically, and with proper diet drug therapy can achieve a better effect.
AB  - Hipertenzija je masovno oboljenje sa visokom stopom smrtnosti od komplikacija koje nastaju. Promena stila života, posebno načina ishrane ima značajnu ulogu u prevenciji nastanka hipertenzije i u odlaganju pojave komplikacija. Ovaj rad razmatra uticaj pojedinih sastojaka hrane (vitamina, oligoelemenata, proteina) na prevenciju i smanjenje povišenog krvnog pritiska. Literatura je pronađena pretraživanjem Medline baze u periodu od 1995. do 2010. godine korišćenjem sledećih ključnih reči: hipertenzija, prevencija hipertenzije, antioksidansi, elektroliti, nutrijenti. Razvoju hipertenzije doprinosi i prekomeran unos natrijuma, kao i nedostatak elektrolita i mikroelemenata u ishrani, kao što su: kalijum, magnezijum, kalcijum, cink i selen. Brojni nutrijenti koji se koriste u prevenciji i tretmanu hipertenzije (hidrolizati proteina soje, surutke, sardine i pšeničnih klica, ω-3 i ω-6 polinezasićene masne kiseline, zeleni i crni čaj, pečurke, vitamin B6, L-arginin, flavonoidi, taurin, alicin iz belog luka, aktivni sastojci gloga) imaju dejstvo slično pojedinim grupama antihipertenzivnih lekova (diuretici, β-blokatori, blokatori kalcijumskih kanala, ACE inhibitori i blokatori angiotenzinskih receptora, centralni α-agonisti, direktni vazodilatatori). Prirodne komponente su od značaja u prevenciji hipertenzije, ali njihova potentnost nije dovoljna da smanji povećani krvni pritisak. Međutim, pojedine prirodne komponente hrane u kombinaciji sa antihipertenzivnim lekovima mogu delovati sinergistički, te se uz odgovarajuću ishranu medikamentoznom terapijom može postići bolji efekat.
PB  - Društvo za ishranu Srbije, Beograd
T2  - Hrana i ishrana
T1  - Relevance of some nutrients in the pre­vention and treatment of hypertension
T1  - Značaj pojedinih nutrijenata u prevenciji i tretmanu hipertenzije
VL  - 52
IS  - 1
SP  - 15
EP  - 22
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1592
ER  - 

@article{
author = "Ilić, Katarina and Hadžibegović, Senka and Đorđević, Brižita",
year = "2011",
abstract = "Oxidative stress, which develops due to imbalance of free radicals and antioxidant factors, has an important role in oxidative stress. The combination of different antioxidants can act sinergistically in the neutralization of free radicals, nitric oxide increase, improvement of vasodilatation and lowering blood pressure. This paper reviews the impact of certain food ingredients (vitamins, oligoelements, proteins) on prevention of hypertension and blood pressure lowering. Literature was found by searching the Medline database from 1995 to 2010 by using the following keywords: hypertension, prevention of hypertension, antioxidants, electrolytes, and nutrients. Excesive natrium intake as well as insufficiency of microelements in nutrition such as calcium, magnesium, zink and selenium contributes to the development of hypertension. A numerous nutritients used in prevention and treatment of hypertension (hydrolisates of soy proteins, whey, sardines, wheat germs, ω-3 and ω-6 unsaturated fatty acids, green and black tea, mushrooms, vitamin B6, L-arginine, flavonoids, taurine, allicin from garlic, active principles of hawtorn) have effects similar to certain groups of antihipertensive drugs (diuretics, beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptors blockers, central α-agonists, direct vasodilatators). Natural components are of importance in the prevention of hypertension but their potency is not sufficient to lower high blood pressure. However, certain individual components of natural food in combination with antihypertensive drugs may act synergistically, and with proper diet drug therapy can achieve a better effect., Hipertenzija je masovno oboljenje sa visokom stopom smrtnosti od komplikacija koje nastaju. Promena stila života, posebno načina ishrane ima značajnu ulogu u prevenciji nastanka hipertenzije i u odlaganju pojave komplikacija. Ovaj rad razmatra uticaj pojedinih sastojaka hrane (vitamina, oligoelemenata, proteina) na prevenciju i smanjenje povišenog krvnog pritiska. Literatura je pronađena pretraživanjem Medline baze u periodu od 1995. do 2010. godine korišćenjem sledećih ključnih reči: hipertenzija, prevencija hipertenzije, antioksidansi, elektroliti, nutrijenti. Razvoju hipertenzije doprinosi i prekomeran unos natrijuma, kao i nedostatak elektrolita i mikroelemenata u ishrani, kao što su: kalijum, magnezijum, kalcijum, cink i selen. Brojni nutrijenti koji se koriste u prevenciji i tretmanu hipertenzije (hidrolizati proteina soje, surutke, sardine i pšeničnih klica, ω-3 i ω-6 polinezasićene masne kiseline, zeleni i crni čaj, pečurke, vitamin B6, L-arginin, flavonoidi, taurin, alicin iz belog luka, aktivni sastojci gloga) imaju dejstvo slično pojedinim grupama antihipertenzivnih lekova (diuretici, β-blokatori, blokatori kalcijumskih kanala, ACE inhibitori i blokatori angiotenzinskih receptora, centralni α-agonisti, direktni vazodilatatori). Prirodne komponente su od značaja u prevenciji hipertenzije, ali njihova potentnost nije dovoljna da smanji povećani krvni pritisak. Međutim, pojedine prirodne komponente hrane u kombinaciji sa antihipertenzivnim lekovima mogu delovati sinergistički, te se uz odgovarajuću ishranu medikamentoznom terapijom može postići bolji efekat.",
publisher = "Društvo za ishranu Srbije, Beograd",
journal = "Hrana i ishrana",
title = "Relevance of some nutrients in the pre­vention and treatment of hypertension, Značaj pojedinih nutrijenata u prevenciji i tretmanu hipertenzije",
volume = "52",
number = "1",
pages = "15-22",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1592"
}

Ilić, K., Hadžibegović, S.,& Đorđević, B.. (2011). Relevance of some nutrients in the pre­vention and treatment of hypertension. in Hrana i ishrana
Društvo za ishranu Srbije, Beograd., 52(1), 15-22.
https://hdl.handle.net/21.15107/rcub_farfar_1592

Ilić K, Hadžibegović S, Đorđević B. Relevance of some nutrients in the pre­vention and treatment of hypertension. in Hrana i ishrana. 2011;52(1):15-22.
https://hdl.handle.net/21.15107/rcub_farfar_1592 .

Ilić, Katarina, Hadžibegović, Senka, Đorđević, Brižita, "Relevance of some nutrients in the pre­vention and treatment of hypertension" in Hrana i ishrana, 52, no. 1 (2011):15-22,
https://hdl.handle.net/21.15107/rcub_farfar_1592 .