TY  - JOUR
AU  - Đuretić, Jasmina
AU  - Dimitrijević, Mirjana
AU  - Stojanović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Hamblin, Michael R.
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Leposavić, Gordana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3781
AB  - The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (−IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with −IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.
PB  - Nature Research
T2  - Scientific Reports
T1  - Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
VL  - 11
IS  - 1
DO  - 10.1038/s41598-021-81999-7
ER  - 

@article{
author = "Đuretić, Jasmina and Dimitrijević, Mirjana and Stojanović, Marija and Kotur-Stevuljević, Jelena and Hamblin, Michael R. and Micov, Ana and Stepanović-Petrović, Radica and Leposavić, Gordana",
year = "2021",
abstract = "The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (−IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with −IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis",
volume = "11",
number = "1",
doi = "10.1038/s41598-021-81999-7"
}

Đuretić, J., Dimitrijević, M., Stojanović, M., Kotur-Stevuljević, J., Hamblin, M. R., Micov, A., Stepanović-Petrović, R.,& Leposavić, G.. (2021). Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis. in Scientific Reports
Nature Research., 11(1).
https://doi.org/10.1038/s41598-021-81999-7

Đuretić J, Dimitrijević M, Stojanović M, Kotur-Stevuljević J, Hamblin MR, Micov A, Stepanović-Petrović R, Leposavić G. Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis. in Scientific Reports. 2021;11(1).
doi:10.1038/s41598-021-81999-7 .

Đuretić, Jasmina, Dimitrijević, Mirjana, Stojanović, Marija, Kotur-Stevuljević, Jelena, Hamblin, Michael R., Micov, Ana, Stepanović-Petrović, Radica, Leposavić, Gordana, "Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis" in Scientific Reports, 11, no. 1 (2021),
https://doi.org/10.1038/s41598-021-81999-7 . .