TY  - JOUR
AU  - Gentile, Antonietta
AU  - D’Acquisto, Fulvio
AU  - Leposavić, Gordana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3987
PB  - Frontiers Media S.A.
T2  - Frontiers in Immunology
T1  - Editorial: The Bidirectional Communication Between Neurons and Immune Cells in the Development of Psychiatric, Neurological and Immune-Mediated Disorders
VL  - 12
DO  - 10.3389/fimmu.2021.781151
ER  - 

@article{
author = "Gentile, Antonietta and D’Acquisto, Fulvio and Leposavić, Gordana",
year = "2021",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Immunology",
title = "Editorial: The Bidirectional Communication Between Neurons and Immune Cells in the Development of Psychiatric, Neurological and Immune-Mediated Disorders",
volume = "12",
doi = "10.3389/fimmu.2021.781151"
}

Gentile, A., D’Acquisto, F.,& Leposavić, G.. (2021). Editorial: The Bidirectional Communication Between Neurons and Immune Cells in the Development of Psychiatric, Neurological and Immune-Mediated Disorders. in Frontiers in Immunology
Frontiers Media S.A.., 12.
https://doi.org/10.3389/fimmu.2021.781151

Gentile A, D’Acquisto F, Leposavić G. Editorial: The Bidirectional Communication Between Neurons and Immune Cells in the Development of Psychiatric, Neurological and Immune-Mediated Disorders. in Frontiers in Immunology. 2021;12.
doi:10.3389/fimmu.2021.781151 .

Gentile, Antonietta, D’Acquisto, Fulvio, Leposavić, Gordana, "Editorial: The Bidirectional Communication Between Neurons and Immune Cells in the Development of Psychiatric, Neurological and Immune-Mediated Disorders" in Frontiers in Immunology, 12 (2021),
https://doi.org/10.3389/fimmu.2021.781151 . .

TY  - JOUR
AU  - Major, Benjamin
AU  - Rattazzi, Lorenza
AU  - Brod, Samuel
AU  - Pilipović, Ivan
AU  - Leposavić, Gordana
AU  - D'Acquisto, Fulvio
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2458
AB  - Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p  lt  0.05; p  lt  0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.
PB  - Nature Publishing Group, London
T2  - Scientific World Journal
T1  - Massage-like stroking boosts the immune system in mice
VL  - 5
DO  - 10.1038/srep10913
ER  - 

@article{
author = "Major, Benjamin and Rattazzi, Lorenza and Brod, Samuel and Pilipović, Ivan and Leposavić, Gordana and D'Acquisto, Fulvio",
year = "2015",
abstract = "Recent clinical evidence suggests that the therapeutic effect of massage involves the immune system and that this can be exploited as an adjunct therapy together with standard drug-based approaches. In this study, we investigated the mechanisms behind these effects exploring the immunomodulatory function of stroking as a surrogate of massage-like therapy in mice. C57/BL6 mice were stroked daily for 8 days either with a soft brush or directly with a gloved hand and then analysed for differences in their immune repertoire compared to control non-stroked mice. Our results show that hand-but not brush-stroked mice demonstrated a significant increase in thymic and splenic T cell number (p  lt  0.05; p  lt  0.01). These effects were not associated with significant changes in CD4/CD8 lineage commitment or activation profile. The boosting effects on T cell repertoire of massage-like therapy were associated with a decreased noradrenergic innervation of lymphoid organs and counteracted the immunosuppressive effect of hydrocortisone in vivo. Together our results in mice support the hypothesis that massage-like therapies might be of therapeutic value in the treatment of immunodeficiencies and related disorders and suggest a reduction of the inhibitory noradrenergic tone in lymphoid organs as one of the possible explanations for their immunomodulatory function.",
publisher = "Nature Publishing Group, London",
journal = "Scientific World Journal",
title = "Massage-like stroking boosts the immune system in mice",
volume = "5",
doi = "10.1038/srep10913"
}

Major, B., Rattazzi, L., Brod, S., Pilipović, I., Leposavić, G.,& D'Acquisto, F.. (2015). Massage-like stroking boosts the immune system in mice. in Scientific World Journal
Nature Publishing Group, London., 5.
https://doi.org/10.1038/srep10913

Major B, Rattazzi L, Brod S, Pilipović I, Leposavić G, D'Acquisto F. Massage-like stroking boosts the immune system in mice. in Scientific World Journal. 2015;5.
doi:10.1038/srep10913 .

Major, Benjamin, Rattazzi, Lorenza, Brod, Samuel, Pilipović, Ivan, Leposavić, Gordana, D'Acquisto, Fulvio, "Massage-like stroking boosts the immune system in mice" in Scientific World Journal, 5 (2015),
https://doi.org/10.1038/srep10913 . .