TY  - JOUR
AU  - Mašić, Ivana
AU  - Ilić, Ilija
AU  - Dreu, Rok
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Srcić, Stanko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2179
AB  - Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure
VL  - 40
IS  - 1
SP  - 23
EP  - 32
DO  - 10.3109/03639045.2012.744415
ER  - 

@article{
author = "Mašić, Ivana and Ilić, Ilija and Dreu, Rok and Ibrić, Svetlana and Parojčić, Jelena and Srcić, Stanko",
year = "2014",
abstract = "Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure",
volume = "40",
number = "1",
pages = "23-32",
doi = "10.3109/03639045.2012.744415"
}

Mašić, I., Ilić, I., Dreu, R., Ibrić, S., Parojčić, J.,& Srcić, S.. (2014). Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 40(1), 23-32.
https://doi.org/10.3109/03639045.2012.744415

Mašić I, Ilić I, Dreu R, Ibrić S, Parojčić J, Srcić S. Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure. in Drug Development and Industrial Pharmacy. 2014;40(1):23-32.
doi:10.3109/03639045.2012.744415 .

Mašić, Ivana, Ilić, Ilija, Dreu, Rok, Ibrić, Svetlana, Parojčić, Jelena, Srcić, Stanko, "Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure" in Drug Development and Industrial Pharmacy, 40, no. 1 (2014):23-32,
https://doi.org/10.3109/03639045.2012.744415 . .

TY  - JOUR
AU  - Mašić, Ivana
AU  - Ilić, Ilija
AU  - Dreu, Rok
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1697
AB  - The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and good flow properties. The results obtained indicate that conventional fluid bed granulator may be suitable for production of highly spherical agglomerates, particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absence of interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
VL  - 423
IS  - 2
SP  - 202
EP  - 212
DO  - 10.1016/j.ijpharm.2011.12.013
ER  - 

@article{
author = "Mašić, Ivana and Ilić, Ilija and Dreu, Rok and Ibrić, Svetlana and Parojčić, Jelena and Đurić, Zorica",
year = "2012",
abstract = "The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on drug release rate. Hydrophilic (polyetilenglycol 2000) and hydrophobic meltable binder (glyceryl palmitostearate) were used for in situ fluidized hot melt granulation. Granule size was mainly influenced by binder particle size. Binder content was shown to be important for narrow size distribution and good flow properties. The results obtained indicate that conventional fluid bed granulator may be suitable for production of highly spherical agglomerates, particularly when immersion and layering is dominant agglomeration mechanism. Granule shape was affected by interplay of binder content, binder particle size and granulation time. Solid state analysis confirmed unaltered physical state of the granulate components and the absence of interactions between the active and excipients. Besides the nature and amount of binder, the mechanism of agglomerate formation seems to have an impact on drug dissolution rate. The results of the present study indicate that fluidized hot melt granulation is a promising powder agglomeration technique for spherical granules production.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation",
volume = "423",
number = "2",
pages = "202-212",
doi = "10.1016/j.ijpharm.2011.12.013"
}

Mašić, I., Ilić, I., Dreu, R., Ibrić, S., Parojčić, J.,& Đurić, Z.. (2012). An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 423(2), 202-212.
https://doi.org/10.1016/j.ijpharm.2011.12.013

Mašić I, Ilić I, Dreu R, Ibrić S, Parojčić J, Đurić Z. An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation. in International Journal of Pharmaceutics. 2012;423(2):202-212.
doi:10.1016/j.ijpharm.2011.12.013 .

Mašić, Ivana, Ilić, Ilija, Dreu, Rok, Ibrić, Svetlana, Parojčić, Jelena, Đurić, Zorica, "An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation" in International Journal of Pharmaceutics, 423, no. 2 (2012):202-212,
https://doi.org/10.1016/j.ijpharm.2011.12.013 . .