TY  - JOUR
AU  - Jovanović, Dragana
AU  - Roksandić-Milenković, Marina
AU  - Kotur-Stevuljević, Jelena
AU  - Ceriman, Vesna
AU  - Vukanić, Ivana
AU  - Samardžić, Natalija
AU  - Popević, Spasoje
AU  - Ilić, Branislav
AU  - Gajić, Milija
AU  - Simon, Marioara
AU  - Simon, Ioan
AU  - Spasojević-Kalimanovska, Vesna
AU  - Belić, Milica
AU  - Mirkov, Damjan
AU  - Šumarac, Zorica
AU  - Milenković, Vladislav
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3341
AB  - Background: The objective of this prospective study was to evaluate whether soluble programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) and serum amyloid A1 (SAA1) are potential diagnostic, predictive or prognostic biomarkers in lung cancer. Methods: Lung cancer patients (n=115) with advanced metastatic disease, 101 with non-small cell lung cancer, NSCLC (77 EGFR wild-type NSCLC patients on chemotherapy, 15 EGFR mutation positive adenocarcinoma patients, 9 patients with mPD-L1 Expression >= 50% NSCLC - responders to immunotherapy), and 14 patients with small cell lung cancer (SCLC) were examined. ELISA method was used to determine sPD-L1 and SAA1 concentrations in patients' plasma. Results: Significantly higher blood concentrations of sPD-L1 and SAA1 were noted in lung cancer patients compared with a healthy control group. In PD-L1 + NSCLC patients, a significantly higher sPD-L1 level was noticed compared to any other lung cancer subgroup, as well as the highest average SAA1 value compared to other subgroups. Conclusions: It seems that sPD-1/PD-L1 might be a potential biomarker, prognostic and/or predictive, particularly in patients treated with immunotherapy. Serum amyloid A1 has potential to act as a good predictor of patients' survival, as well as a biomarker of a more advanced disease, with possibly good capability to predict the course of disease measured at different time points.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Soluble sPD-L1 and serum amyloid A1 as potential biomarkers for lung cancer
VL  - 38
IS  - 3
SP  - 332
EP  - 341
DO  - 10.2478/jomb-2018-0036
ER  - 

@article{
author = "Jovanović, Dragana and Roksandić-Milenković, Marina and Kotur-Stevuljević, Jelena and Ceriman, Vesna and Vukanić, Ivana and Samardžić, Natalija and Popević, Spasoje and Ilić, Branislav and Gajić, Milija and Simon, Marioara and Simon, Ioan and Spasojević-Kalimanovska, Vesna and Belić, Milica and Mirkov, Damjan and Šumarac, Zorica and Milenković, Vladislav",
year = "2019",
abstract = "Background: The objective of this prospective study was to evaluate whether soluble programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) and serum amyloid A1 (SAA1) are potential diagnostic, predictive or prognostic biomarkers in lung cancer. Methods: Lung cancer patients (n=115) with advanced metastatic disease, 101 with non-small cell lung cancer, NSCLC (77 EGFR wild-type NSCLC patients on chemotherapy, 15 EGFR mutation positive adenocarcinoma patients, 9 patients with mPD-L1 Expression >= 50% NSCLC - responders to immunotherapy), and 14 patients with small cell lung cancer (SCLC) were examined. ELISA method was used to determine sPD-L1 and SAA1 concentrations in patients' plasma. Results: Significantly higher blood concentrations of sPD-L1 and SAA1 were noted in lung cancer patients compared with a healthy control group. In PD-L1 + NSCLC patients, a significantly higher sPD-L1 level was noticed compared to any other lung cancer subgroup, as well as the highest average SAA1 value compared to other subgroups. Conclusions: It seems that sPD-1/PD-L1 might be a potential biomarker, prognostic and/or predictive, particularly in patients treated with immunotherapy. Serum amyloid A1 has potential to act as a good predictor of patients' survival, as well as a biomarker of a more advanced disease, with possibly good capability to predict the course of disease measured at different time points.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Soluble sPD-L1 and serum amyloid A1 as potential biomarkers for lung cancer",
volume = "38",
number = "3",
pages = "332-341",
doi = "10.2478/jomb-2018-0036"
}

Jovanović, D., Roksandić-Milenković, M., Kotur-Stevuljević, J., Ceriman, V., Vukanić, I., Samardžić, N., Popević, S., Ilić, B., Gajić, M., Simon, M., Simon, I., Spasojević-Kalimanovska, V., Belić, M., Mirkov, D., Šumarac, Z.,& Milenković, V.. (2019). Soluble sPD-L1 and serum amyloid A1 as potential biomarkers for lung cancer. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 332-341.
https://doi.org/10.2478/jomb-2018-0036

Jovanović D, Roksandić-Milenković M, Kotur-Stevuljević J, Ceriman V, Vukanić I, Samardžić N, Popević S, Ilić B, Gajić M, Simon M, Simon I, Spasojević-Kalimanovska V, Belić M, Mirkov D, Šumarac Z, Milenković V. Soluble sPD-L1 and serum amyloid A1 as potential biomarkers for lung cancer. in Journal of Medical Biochemistry. 2019;38(3):332-341.
doi:10.2478/jomb-2018-0036 .

Jovanović, Dragana, Roksandić-Milenković, Marina, Kotur-Stevuljević, Jelena, Ceriman, Vesna, Vukanić, Ivana, Samardžić, Natalija, Popević, Spasoje, Ilić, Branislav, Gajić, Milija, Simon, Marioara, Simon, Ioan, Spasojević-Kalimanovska, Vesna, Belić, Milica, Mirkov, Damjan, Šumarac, Zorica, Milenković, Vladislav, "Soluble sPD-L1 and serum amyloid A1 as potential biomarkers for lung cancer" in Journal of Medical Biochemistry, 38, no. 3 (2019):332-341,
https://doi.org/10.2478/jomb-2018-0036 . .

TY  - CONF
AU  - Jovanović, Dragana M.
AU  - Kotur-Stevuljević, Jelena
AU  - Marković, Jelena
AU  - Loncarević, Olivera
AU  - Simon, Marioara
AU  - Milenković, Marina
AU  - Vukanić, Ivana
AU  - Kontić, Milica
AU  - Samardžić, Natalija
AU  - Ceriman, Vesna
AU  - Popević, Spasoje
AU  - Glumac, Sofija
AU  - Skodrić-Trifunović, Vesna
AU  - Radojević-Skodrić, Sanja
AU  - Ilić, Branislav
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3133
PB  - European Respiratory Soc Journals Ltd, Sheffield
C3  - European Respiratory Journal
T1  - PD-L1 expression on alveolar macrophages and in plasma of IPF patients - original research
VL  - 52
DO  - 10.1183/13993003.congress-2018.PA4232
ER  - 

@conference{
author = "Jovanović, Dragana M. and Kotur-Stevuljević, Jelena and Marković, Jelena and Loncarević, Olivera and Simon, Marioara and Milenković, Marina and Vukanić, Ivana and Kontić, Milica and Samardžić, Natalija and Ceriman, Vesna and Popević, Spasoje and Glumac, Sofija and Skodrić-Trifunović, Vesna and Radojević-Skodrić, Sanja and Ilić, Branislav",
year = "2018",
publisher = "European Respiratory Soc Journals Ltd, Sheffield",
journal = "European Respiratory Journal",
title = "PD-L1 expression on alveolar macrophages and in plasma of IPF patients - original research",
volume = "52",
doi = "10.1183/13993003.congress-2018.PA4232"
}

Jovanović, D. M., Kotur-Stevuljević, J., Marković, J., Loncarević, O., Simon, M., Milenković, M., Vukanić, I., Kontić, M., Samardžić, N., Ceriman, V., Popević, S., Glumac, S., Skodrić-Trifunović, V., Radojević-Skodrić, S.,& Ilić, B.. (2018). PD-L1 expression on alveolar macrophages and in plasma of IPF patients - original research. in European Respiratory Journal
European Respiratory Soc Journals Ltd, Sheffield., 52.
https://doi.org/10.1183/13993003.congress-2018.PA4232

Jovanović DM, Kotur-Stevuljević J, Marković J, Loncarević O, Simon M, Milenković M, Vukanić I, Kontić M, Samardžić N, Ceriman V, Popević S, Glumac S, Skodrić-Trifunović V, Radojević-Skodrić S, Ilić B. PD-L1 expression on alveolar macrophages and in plasma of IPF patients - original research. in European Respiratory Journal. 2018;52.
doi:10.1183/13993003.congress-2018.PA4232 .

Jovanović, Dragana M., Kotur-Stevuljević, Jelena, Marković, Jelena, Loncarević, Olivera, Simon, Marioara, Milenković, Marina, Vukanić, Ivana, Kontić, Milica, Samardžić, Natalija, Ceriman, Vesna, Popević, Spasoje, Glumac, Sofija, Skodrić-Trifunović, Vesna, Radojević-Skodrić, Sanja, Ilić, Branislav, "PD-L1 expression on alveolar macrophages and in plasma of IPF patients - original research" in European Respiratory Journal, 52 (2018),
https://doi.org/10.1183/13993003.congress-2018.PA4232 . .

TY  - CONF
AU  - Jovanović, Dragana M.
AU  - Kotur-Stevuljević, Jelena
AU  - Roksandić-Milenković, Marina
AU  - Simon, Marioara
AU  - Ceriman, Vesna
AU  - Popević, Spasoje
AU  - Vukanić, Ivana
AU  - Samardžić, Natalija
AU  - Kontić, Milica
AU  - Ilić, Branislav
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3119
PB  - European Respiratory Soc Journals Ltd, Sheffield
C3  - European Respiratory Journal
T1  - Soluble sPD-L1 plasma concentrations in a series of 95 lung cancer patients
VL  - 52
DO  - 10.1183/13993003.congress-2018.PA2218
ER  - 

@conference{
author = "Jovanović, Dragana M. and Kotur-Stevuljević, Jelena and Roksandić-Milenković, Marina and Simon, Marioara and Ceriman, Vesna and Popević, Spasoje and Vukanić, Ivana and Samardžić, Natalija and Kontić, Milica and Ilić, Branislav",
year = "2018",
publisher = "European Respiratory Soc Journals Ltd, Sheffield",
journal = "European Respiratory Journal",
title = "Soluble sPD-L1 plasma concentrations in a series of 95 lung cancer patients",
volume = "52",
doi = "10.1183/13993003.congress-2018.PA2218"
}

Jovanović, D. M., Kotur-Stevuljević, J., Roksandić-Milenković, M., Simon, M., Ceriman, V., Popević, S., Vukanić, I., Samardžić, N., Kontić, M.,& Ilić, B.. (2018). Soluble sPD-L1 plasma concentrations in a series of 95 lung cancer patients. in European Respiratory Journal
European Respiratory Soc Journals Ltd, Sheffield., 52.
https://doi.org/10.1183/13993003.congress-2018.PA2218

Jovanović DM, Kotur-Stevuljević J, Roksandić-Milenković M, Simon M, Ceriman V, Popević S, Vukanić I, Samardžić N, Kontić M, Ilić B. Soluble sPD-L1 plasma concentrations in a series of 95 lung cancer patients. in European Respiratory Journal. 2018;52.
doi:10.1183/13993003.congress-2018.PA2218 .

Jovanović, Dragana M., Kotur-Stevuljević, Jelena, Roksandić-Milenković, Marina, Simon, Marioara, Ceriman, Vesna, Popević, Spasoje, Vukanić, Ivana, Samardžić, Natalija, Kontić, Milica, Ilić, Branislav, "Soluble sPD-L1 plasma concentrations in a series of 95 lung cancer patients" in European Respiratory Journal, 52 (2018),
https://doi.org/10.1183/13993003.congress-2018.PA2218 . .