TY  - JOUR
AU  - Šumarac, Zorica
AU  - Suvajdzić, Nada
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Janić, Dragana
AU  - Petakov, Milan
AU  - Đorđević, Maja
AU  - Mitrović, Mirjana
AU  - Dajak, Marijana
AU  - Golubović, Milka
AU  - Rodić, Predrag
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1553
AB  - Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers in Serbian patients with Gaucher disease
VL  - 44
IS  - 12
SP  - 950
EP  - 954
DO  - 10.1016/j.clinbiochem.2011.05.016
ER  - 

@article{
author = "Šumarac, Zorica and Suvajdzić, Nada and Ignjatović, Svetlana and Majkić-Singh, Nada and Janić, Dragana and Petakov, Milan and Đorđević, Maja and Mitrović, Mirjana and Dajak, Marijana and Golubović, Milka and Rodić, Predrag",
year = "2011",
abstract = "Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers in Serbian patients with Gaucher disease",
volume = "44",
number = "12",
pages = "950-954",
doi = "10.1016/j.clinbiochem.2011.05.016"
}

Šumarac, Z., Suvajdzić, N., Ignjatović, S., Majkić-Singh, N., Janić, D., Petakov, M., Đorđević, M., Mitrović, M., Dajak, M., Golubović, M.,& Rodić, P.. (2011). Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 44(12), 950-954.
https://doi.org/10.1016/j.clinbiochem.2011.05.016

Šumarac Z, Suvajdzić N, Ignjatović S, Majkić-Singh N, Janić D, Petakov M, Đorđević M, Mitrović M, Dajak M, Golubović M, Rodić P. Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry. 2011;44(12):950-954.
doi:10.1016/j.clinbiochem.2011.05.016 .

Šumarac, Zorica, Suvajdzić, Nada, Ignjatović, Svetlana, Majkić-Singh, Nada, Janić, Dragana, Petakov, Milan, Đorđević, Maja, Mitrović, Mirjana, Dajak, Marijana, Golubović, Milka, Rodić, Predrag, "Biomarkers in Serbian patients with Gaucher disease" in Clinical Biochemistry, 44, no. 12 (2011):950-954,
https://doi.org/10.1016/j.clinbiochem.2011.05.016 . .