TY  - JOUR
AU  - Kuntić, Vesna
AU  - Filipović, IM
AU  - Mioč, Ubavka B.
AU  - Jelić, SB
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/165
AB  - The influence of various crystalohydrates of tungstophosphoric acid (WPA): 29-WPA, 6-WPA, 0-WPA and ''D''-WPA, as well as of various crystalohydrates of neutral Na salt (Na(3)WPA): 16-Na(3)WPA, 6-Na(3)WPA and 0-Na(3)WPA, were tested for their tit vitro effect on plasma coagulation by ''screening'' tests - by measuring aPTT, TT and PT. It was found that different crystalohydrates of WPA prolong aPTT according to the number of water molecules, slightly reduce TT, no matter of water molecules, and have no significant effect on PT: Na(3)WPA acts in the same way as WPA, but in a ten times higher concentration. aPTT prolongation is caused mainly by inhibition of Factor Ut. When WPA is added to plasma together with heparin, aPTT is more prolonged and TT is shortened, while Na(3)WPA with heparin prolongs both aPTT and TT. The proposed mechanism of WPA and Na(3)WPA activity is the charge interaction with ATIII and through hydrogen bonding with Factor IX.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Anticoagulant effect of various crystallohydrates of tungstophosphoric acid and their Na salt and proposed acting mechanism
VL  - 16
IS  - 1
SP  - 15
EP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_farfar_165
ER  - 

@article{
author = "Kuntić, Vesna and Filipović, IM and Mioč, Ubavka B. and Jelić, SB",
year = "1997",
abstract = "The influence of various crystalohydrates of tungstophosphoric acid (WPA): 29-WPA, 6-WPA, 0-WPA and ''D''-WPA, as well as of various crystalohydrates of neutral Na salt (Na(3)WPA): 16-Na(3)WPA, 6-Na(3)WPA and 0-Na(3)WPA, were tested for their tit vitro effect on plasma coagulation by ''screening'' tests - by measuring aPTT, TT and PT. It was found that different crystalohydrates of WPA prolong aPTT according to the number of water molecules, slightly reduce TT, no matter of water molecules, and have no significant effect on PT: Na(3)WPA acts in the same way as WPA, but in a ten times higher concentration. aPTT prolongation is caused mainly by inhibition of Factor Ut. When WPA is added to plasma together with heparin, aPTT is more prolonged and TT is shortened, while Na(3)WPA with heparin prolongs both aPTT and TT. The proposed mechanism of WPA and Na(3)WPA activity is the charge interaction with ATIII and through hydrogen bonding with Factor IX.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Anticoagulant effect of various crystallohydrates of tungstophosphoric acid and their Na salt and proposed acting mechanism",
volume = "16",
number = "1",
pages = "15-19",
url = "https://hdl.handle.net/21.15107/rcub_farfar_165"
}

Kuntić, V., Filipović, I., Mioč, U. B.,& Jelić, S.. (1997). Anticoagulant effect of various crystallohydrates of tungstophosphoric acid and their Na salt and proposed acting mechanism. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 16(1), 15-19.
https://hdl.handle.net/21.15107/rcub_farfar_165

Kuntić V, Filipović I, Mioč UB, Jelić S. Anticoagulant effect of various crystallohydrates of tungstophosphoric acid and their Na salt and proposed acting mechanism. in Jugoslovenska medicinska biohemija. 1997;16(1):15-19.
https://hdl.handle.net/21.15107/rcub_farfar_165 .

Kuntić, Vesna, Filipović, IM, Mioč, Ubavka B., Jelić, SB, "Anticoagulant effect of various crystallohydrates of tungstophosphoric acid and their Na salt and proposed acting mechanism" in Jugoslovenska medicinska biohemija, 16, no. 1 (1997):15-19,
https://hdl.handle.net/21.15107/rcub_farfar_165 .

TY  - JOUR
AU  - Mioč, Ubavka B.
AU  - Kuntić, Vesna
AU  - Nedić, Zoran P.
AU  - Filipović, I.M
AU  - Jelić, S.B
PY  - 1996
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/141
AB  - The influence of the Li and Na salts of 12-tungstophosphoric acid H3P W12O40(WPA) was tested for in vitro effects on blood coagulation. It was found that only Li3WPA shows anticoagulant effects, but compared with WPA activity, the activity of Li salt is diminished. IR spectroscopy was used to define the reaction between these salts, and coagulation proteins. The appearance of bands characteristic of oxonium ion (H3O+) in the IR spectra indicates blocking of the active center of the protein through a very strong hydrogen bond.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy
VL  - 61
IS  - 9
SP  - 767
EP  - 771
UR  - https://hdl.handle.net/21.15107/rcub_farfar_141
ER  - 

@article{
author = "Mioč, Ubavka B. and Kuntić, Vesna and Nedić, Zoran P. and Filipović, I.M and Jelić, S.B",
year = "1996",
abstract = "The influence of the Li and Na salts of 12-tungstophosphoric acid H3P W12O40(WPA) was tested for in vitro effects on blood coagulation. It was found that only Li3WPA shows anticoagulant effects, but compared with WPA activity, the activity of Li salt is diminished. IR spectroscopy was used to define the reaction between these salts, and coagulation proteins. The appearance of bands characteristic of oxonium ion (H3O+) in the IR spectra indicates blocking of the active center of the protein through a very strong hydrogen bond.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy",
volume = "61",
number = "9",
pages = "767-771",
url = "https://hdl.handle.net/21.15107/rcub_farfar_141"
}

Mioč, U. B., Kuntić, V., Nedić, Z. P., Filipović, I.M,& Jelić, S.B. (1996). Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 61(9), 767-771.
https://hdl.handle.net/21.15107/rcub_farfar_141

Mioč UB, Kuntić V, Nedić ZP, Filipović I, Jelić S. Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy. in Journal of the Serbian Chemical Society. 1996;61(9):767-771.
https://hdl.handle.net/21.15107/rcub_farfar_141 .

Mioč, Ubavka B., Kuntić, Vesna, Nedić, Zoran P., Filipović, I.M, Jelić, S.B, "Anticoagulant effect of tungstophosphoric acid salt studied by IR spectroscopy" in Journal of the Serbian Chemical Society, 61, no. 9 (1996):767-771,
https://hdl.handle.net/21.15107/rcub_farfar_141 .