TY  - JOUR
AU  - Popović, Dejana
AU  - Bjelobrk, Marija
AU  - Tesić, Milorad
AU  - Seman, Stefan
AU  - Jayasinghe, Sisitha
AU  - Hills, Andrew
AU  - Samuel Babu, Abraham
AU  - Jakovljević, Đorđe.
AU  - Stoner, Lee
AU  - Ozemek, Cemal
AU  - Bond, Samantha
AU  - Faghy, Mark
AU  - Pronk, Nicolaas
AU  - Lavie, Carl
AU  - Arena, Ross
AU  - On behalf of the HL - PIVOT Network
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4064
AB  - Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.
PB  - W.B. Saunders
T2  - Progress in Cardiovascular Diseases
T1  - Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise
DO  - 10.1016/j.pcad.2022.01.008
ER  - 

@article{
author = "Popović, Dejana and Bjelobrk, Marija and Tesić, Milorad and Seman, Stefan and Jayasinghe, Sisitha and Hills, Andrew and Samuel Babu, Abraham and Jakovljević, Đorđe. and Stoner, Lee and Ozemek, Cemal and Bond, Samantha and Faghy, Mark and Pronk, Nicolaas and Lavie, Carl and Arena, Ross and On behalf of the HL - PIVOT Network",
year = "2022",
abstract = "Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.",
publisher = "W.B. Saunders",
journal = "Progress in Cardiovascular Diseases",
title = "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise",
doi = "10.1016/j.pcad.2022.01.008"
}

Popović, D., Bjelobrk, M., Tesić, M., Seman, S., Jayasinghe, S., Hills, A., Samuel Babu, A., Jakovljević, Đorđe., Stoner, L., Ozemek, C., Bond, S., Faghy, M., Pronk, N., Lavie, C., Arena, R.,& On behalf of the HL - PIVOT Network. (2022). Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases
W.B. Saunders..
https://doi.org/10.1016/j.pcad.2022.01.008

Popović D, Bjelobrk M, Tesić M, Seman S, Jayasinghe S, Hills A, Samuel Babu A, Jakovljević Đ, Stoner L, Ozemek C, Bond S, Faghy M, Pronk N, Lavie C, Arena R, On behalf of the HL - PIVOT Network. Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases. 2022;.
doi:10.1016/j.pcad.2022.01.008 .

Popović, Dejana, Bjelobrk, Marija, Tesić, Milorad, Seman, Stefan, Jayasinghe, Sisitha, Hills, Andrew, Samuel Babu, Abraham, Jakovljević, Đorđe., Stoner, Lee, Ozemek, Cemal, Bond, Samantha, Faghy, Mark, Pronk, Nicolaas, Lavie, Carl, Arena, Ross, On behalf of the HL - PIVOT Network, "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise" in Progress in Cardiovascular Diseases (2022),
https://doi.org/10.1016/j.pcad.2022.01.008 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Damjanović, Svetozar
AU  - Popović, Bojana
AU  - Kocijančić, Aleksandar
AU  - Labudović, Dragana
AU  - Seman, Stefan
AU  - Stojiljković, Stanimir
AU  - Tesić, Milorad
AU  - Arena, Ross
AU  - Lasica, Ratko
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4020
AB  - Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary parameters and stress hormones during anticipation of stress in different chronic stress adaptive models is needed. As an addition to our previous research, a total of 57 subjects (16 elite male wrestlers, 21 water polo player and 20 sedentary subjects matched for age) were analyzed. Cardiopulmonary exercise testing (CPET) on a treadmill was used as the laboratory stress model; peak oxygen consumption (VO2) was obtained during CPET. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte stimulating hormone (alpha-MSH) and N-terminal-pro-B type natriuretic peptide (NT-pro-BNP) were measured by radioimmunometric, radioimmunoassay and immunoassay sandwich technique, respectively, together with cardiopulmonary measurements, 10 minutes pre-CPET and at the initiation of CPET. The response of diastolic blood pressure and heart rate was different between groups during stress anticipation (p¼0.019, 0.049, respectively), while systolic blood pressure, peak VO2 and carbon-dioxide production responses were similar. ACTH and cortisol increased during the experimental condition, NT-pro-BNP decreased and alpha-MSH remained unchanged. All groups had similar hormonal responses during stress anticipation with the exception of the ACTH/cortisol ratio. In all three groups, DNT-pro-BNP during stress anticipation was the best independent predictor of peak VO2 (B¼36.01, r¼0.37, p¼0.001). In conclusion, the type of chronic stress exposure influences the hemodynamic response during anticipation of physical stress and the path of hormonal stress axis activation. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. LAY SUMMARY The study revealed differences in hormonal and hemodynamic responses during anticipation of stress between athletes and sedentary participants. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. Abbreviations: ACTH: adrenocorticitropic hormone; BSA: body surface area; BW: body weight; C: controls; CPET: cardiopulmonary exercise test; DBP: diastolic arterial blood pressure; FFM: fat-free mass; FM: fat mass; HR: heart rate; MSH: melanocyte-stimulating hormone; NT-pro-BNP: N terminal-pro-B type natriuretic peptide; SBP: systolic arterial blood pressure; VCO2: carbon dioxide production; VE: minute ventilation; VO2: oxygen consumption; W: wrestlers; WP: water polo players
PB  - Taylor and Francis Ltd.
T2  - Stress
T1  - Physiological behavior during stress anticipation across different chronic stress exposure adaptive models
DO  - 10.1080/10253890.2021.2006178
ER  - 

@article{
author = "Popović, Dejana and Damjanović, Svetozar and Popović, Bojana and Kocijančić, Aleksandar and Labudović, Dragana and Seman, Stefan and Stojiljković, Stanimir and Tesić, Milorad and Arena, Ross and Lasica, Ratko",
year = "2021",
abstract = "Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary parameters and stress hormones during anticipation of stress in different chronic stress adaptive models is needed. As an addition to our previous research, a total of 57 subjects (16 elite male wrestlers, 21 water polo player and 20 sedentary subjects matched for age) were analyzed. Cardiopulmonary exercise testing (CPET) on a treadmill was used as the laboratory stress model; peak oxygen consumption (VO2) was obtained during CPET. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte stimulating hormone (alpha-MSH) and N-terminal-pro-B type natriuretic peptide (NT-pro-BNP) were measured by radioimmunometric, radioimmunoassay and immunoassay sandwich technique, respectively, together with cardiopulmonary measurements, 10 minutes pre-CPET and at the initiation of CPET. The response of diastolic blood pressure and heart rate was different between groups during stress anticipation (p¼0.019, 0.049, respectively), while systolic blood pressure, peak VO2 and carbon-dioxide production responses were similar. ACTH and cortisol increased during the experimental condition, NT-pro-BNP decreased and alpha-MSH remained unchanged. All groups had similar hormonal responses during stress anticipation with the exception of the ACTH/cortisol ratio. In all three groups, DNT-pro-BNP during stress anticipation was the best independent predictor of peak VO2 (B¼36.01, r¼0.37, p¼0.001). In conclusion, the type of chronic stress exposure influences the hemodynamic response during anticipation of physical stress and the path of hormonal stress axis activation. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. LAY SUMMARY The study revealed differences in hormonal and hemodynamic responses during anticipation of stress between athletes and sedentary participants. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. Abbreviations: ACTH: adrenocorticitropic hormone; BSA: body surface area; BW: body weight; C: controls; CPET: cardiopulmonary exercise test; DBP: diastolic arterial blood pressure; FFM: fat-free mass; FM: fat mass; HR: heart rate; MSH: melanocyte-stimulating hormone; NT-pro-BNP: N terminal-pro-B type natriuretic peptide; SBP: systolic arterial blood pressure; VCO2: carbon dioxide production; VE: minute ventilation; VO2: oxygen consumption; W: wrestlers; WP: water polo players",
publisher = "Taylor and Francis Ltd.",
journal = "Stress",
title = "Physiological behavior during stress anticipation across different chronic stress exposure adaptive models",
doi = "10.1080/10253890.2021.2006178"
}

Popović, D., Damjanović, S., Popović, B., Kocijančić, A., Labudović, D., Seman, S., Stojiljković, S., Tesić, M., Arena, R.,& Lasica, R.. (2021). Physiological behavior during stress anticipation across different chronic stress exposure adaptive models. in Stress
Taylor and Francis Ltd...
https://doi.org/10.1080/10253890.2021.2006178

Popović D, Damjanović S, Popović B, Kocijančić A, Labudović D, Seman S, Stojiljković S, Tesić M, Arena R, Lasica R. Physiological behavior during stress anticipation across different chronic stress exposure adaptive models. in Stress. 2021;.
doi:10.1080/10253890.2021.2006178 .

Popović, Dejana, Damjanović, Svetozar, Popović, Bojana, Kocijančić, Aleksandar, Labudović, Dragana, Seman, Stefan, Stojiljković, Stanimir, Tesić, Milorad, Arena, Ross, Lasica, Ratko, "Physiological behavior during stress anticipation across different chronic stress exposure adaptive models" in Stress (2021),
https://doi.org/10.1080/10253890.2021.2006178 . .

TY  - JOUR
AU  - Seferović, Jelena
AU  - Lalić, Nebojša M.
AU  - Floridi, Federico
AU  - Tesić, Milorad
AU  - Seferović, Petar M.
AU  - Giga, Vojislav
AU  - Lalić, Katarina
AU  - Jotić, Aleksandra
AU  - Jovičić, Snežana
AU  - Colak, Emina
AU  - Salerno, Gerardo
AU  - Cardelli, Patrizia
AU  - Di Somma, Salvatore
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2074
AB  - Background: Galectin-3 is a protein widely distributed in the heart, brain and blood vessels, and has a regulatory role in inflammation, immunology and cancer. Many studies demonstrated that the increased level of galectin-3 is associated with progressive fibrosis and stiffening of the myocardium. The aim of this study was to investigate the role of galectin-3 in patients with type 2 diabetes (T2D) and/or arterial hypertension (HT). Methods: Study population included 189 patients, with no coronary artery disease, divided into three groups: group 1 (T2D), group 2 (T2D+HT), and group 3 (HT). All subjects underwent routine laboratory tests, as well as specific biomarkers assessment [galectin-3, glycosylated hemoglobin (HbA(1c)), N- terminal fragment B-type natriuretic peptide (NT-proBNP)]. Cardiological evaluation included physical examination, transthoracic tissue Doppler echocardiography and stress echocardiography. Results: The results of this study demonstrated significantly increased levels of galectin-3, blood glucose, and HbA(1c) in group 2. Also, echocardiographicaly, left ventricular (LV) diameters and IVS thickness were increased in this group of patients. Furthermore, in the same cohort a positive correlation between galectin-3 and NT-pro BNP, and galectin-3 and LV mass were demonstrated. In addition, a negative correlation between galectin-3 and LV end-diastolic diameter was revealed. Conclusions: This study revealed that levels of galectin-3 were higher in patients with both T2D and HT, and correlated with LV mass, indicating the potential role of this biomarker for early detection of myocardial structural and functional alterations.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Structural myocardial alterations in diabetes and hypertension: the role of galectin-3
VL  - 52
IS  - 10
SP  - 1499
EP  - 1505
DO  - 10.1515/cclm-2014-0265
ER  - 

@article{
author = "Seferović, Jelena and Lalić, Nebojša M. and Floridi, Federico and Tesić, Milorad and Seferović, Petar M. and Giga, Vojislav and Lalić, Katarina and Jotić, Aleksandra and Jovičić, Snežana and Colak, Emina and Salerno, Gerardo and Cardelli, Patrizia and Di Somma, Salvatore",
year = "2014",
abstract = "Background: Galectin-3 is a protein widely distributed in the heart, brain and blood vessels, and has a regulatory role in inflammation, immunology and cancer. Many studies demonstrated that the increased level of galectin-3 is associated with progressive fibrosis and stiffening of the myocardium. The aim of this study was to investigate the role of galectin-3 in patients with type 2 diabetes (T2D) and/or arterial hypertension (HT). Methods: Study population included 189 patients, with no coronary artery disease, divided into three groups: group 1 (T2D), group 2 (T2D+HT), and group 3 (HT). All subjects underwent routine laboratory tests, as well as specific biomarkers assessment [galectin-3, glycosylated hemoglobin (HbA(1c)), N- terminal fragment B-type natriuretic peptide (NT-proBNP)]. Cardiological evaluation included physical examination, transthoracic tissue Doppler echocardiography and stress echocardiography. Results: The results of this study demonstrated significantly increased levels of galectin-3, blood glucose, and HbA(1c) in group 2. Also, echocardiographicaly, left ventricular (LV) diameters and IVS thickness were increased in this group of patients. Furthermore, in the same cohort a positive correlation between galectin-3 and NT-pro BNP, and galectin-3 and LV mass were demonstrated. In addition, a negative correlation between galectin-3 and LV end-diastolic diameter was revealed. Conclusions: This study revealed that levels of galectin-3 were higher in patients with both T2D and HT, and correlated with LV mass, indicating the potential role of this biomarker for early detection of myocardial structural and functional alterations.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Structural myocardial alterations in diabetes and hypertension: the role of galectin-3",
volume = "52",
number = "10",
pages = "1499-1505",
doi = "10.1515/cclm-2014-0265"
}

Seferović, J., Lalić, N. M., Floridi, F., Tesić, M., Seferović, P. M., Giga, V., Lalić, K., Jotić, A., Jovičić, S., Colak, E., Salerno, G., Cardelli, P.,& Di Somma, S.. (2014). Structural myocardial alterations in diabetes and hypertension: the role of galectin-3. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 52(10), 1499-1505.
https://doi.org/10.1515/cclm-2014-0265

Seferović J, Lalić NM, Floridi F, Tesić M, Seferović PM, Giga V, Lalić K, Jotić A, Jovičić S, Colak E, Salerno G, Cardelli P, Di Somma S. Structural myocardial alterations in diabetes and hypertension: the role of galectin-3. in Clinical Chemistry and Laboratory Medicine. 2014;52(10):1499-1505.
doi:10.1515/cclm-2014-0265 .

Seferović, Jelena, Lalić, Nebojša M., Floridi, Federico, Tesić, Milorad, Seferović, Petar M., Giga, Vojislav, Lalić, Katarina, Jotić, Aleksandra, Jovičić, Snežana, Colak, Emina, Salerno, Gerardo, Cardelli, Patrizia, Di Somma, Salvatore, "Structural myocardial alterations in diabetes and hypertension: the role of galectin-3" in Clinical Chemistry and Laboratory Medicine, 52, no. 10 (2014):1499-1505,
https://doi.org/10.1515/cclm-2014-0265 . .

TY  - JOUR
AU  - Dobrić, Milan
AU  - Giga, Vojislav
AU  - Beleslin, Branko
AU  - Ignjatović, Svetlana
AU  - Paunović, Ivana
AU  - Stepanović, Jelena M.
AU  - Đorđević-Dikić, Ana
AU  - Kostić, Jelena
AU  - Nedeljković, Ivana
AU  - Nedeljković, Milan
AU  - Tesić, Milorad
AU  - Dajak, Marijana
AU  - Ostojić, Miodrag
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1868
AB  - Background: Glycogen phosphorylase BB (GPBB) is released from cardiac cells during myocyte damage. Previous studies have shown contradictory results regarding the relation of enzyme release and reversible myocardial ischemia. The aim of this study was to determine the plasma kinetics of GPBB as a response to the exercise stress echocardiographic test (ESET), and to define the relationship between myocardial ischemia and enzyme plasma concentrations. Methods: We studied 46 consecutive patients undergoing ESET, with recent coronary angiography. In all patients, a submaximal stress echo test according to Bruce protocol was performed. Concentration of GPBB was measured in peripheral blood that was sampled 5 min before and 10, 30 and 60 min after ESET. Results: There was significant increase of GPBB concentration after the test (p=0.021). Significant increase was detected 30 min (34.9% increase, p=0.021) and 60 min (34.5% increase, p=0.016) after ESET. There was no significant effect of myocardial ischemia on GPBB concentrations (p=0.126), and no significant interaction between sampling intervals and myocardial ischemia, suggesting a similar release profile of GPBB in ischemic and non-ischemic conditions (p=0.558). Patients in whom ESET was terminated later (stages 4 or 5 of standard Bruce protocol; n=13) had higher GPBB concentrations than patients who terminated ESET earlier (stages 1, 2 or 3; n=33) (p=0.049). Baseline GPBB concentration was not correlated to any of the patients' demographic, clinical and hemodynamic characteristics. Conclusions: GPBB plasma concentration increases after ESET, and it is not related to inducible myocardial ischemia. However, it seems that GPBB release during ESET might be related to exercise load/duration.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test
VL  - 51
IS  - 10
SP  - 2029
EP  - 2035
DO  - 10.1515/cclm-2013-0109
ER  - 

@article{
author = "Dobrić, Milan and Giga, Vojislav and Beleslin, Branko and Ignjatović, Svetlana and Paunović, Ivana and Stepanović, Jelena M. and Đorđević-Dikić, Ana and Kostić, Jelena and Nedeljković, Ivana and Nedeljković, Milan and Tesić, Milorad and Dajak, Marijana and Ostojić, Miodrag",
year = "2013",
abstract = "Background: Glycogen phosphorylase BB (GPBB) is released from cardiac cells during myocyte damage. Previous studies have shown contradictory results regarding the relation of enzyme release and reversible myocardial ischemia. The aim of this study was to determine the plasma kinetics of GPBB as a response to the exercise stress echocardiographic test (ESET), and to define the relationship between myocardial ischemia and enzyme plasma concentrations. Methods: We studied 46 consecutive patients undergoing ESET, with recent coronary angiography. In all patients, a submaximal stress echo test according to Bruce protocol was performed. Concentration of GPBB was measured in peripheral blood that was sampled 5 min before and 10, 30 and 60 min after ESET. Results: There was significant increase of GPBB concentration after the test (p=0.021). Significant increase was detected 30 min (34.9% increase, p=0.021) and 60 min (34.5% increase, p=0.016) after ESET. There was no significant effect of myocardial ischemia on GPBB concentrations (p=0.126), and no significant interaction between sampling intervals and myocardial ischemia, suggesting a similar release profile of GPBB in ischemic and non-ischemic conditions (p=0.558). Patients in whom ESET was terminated later (stages 4 or 5 of standard Bruce protocol; n=13) had higher GPBB concentrations than patients who terminated ESET earlier (stages 1, 2 or 3; n=33) (p=0.049). Baseline GPBB concentration was not correlated to any of the patients' demographic, clinical and hemodynamic characteristics. Conclusions: GPBB plasma concentration increases after ESET, and it is not related to inducible myocardial ischemia. However, it seems that GPBB release during ESET might be related to exercise load/duration.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test",
volume = "51",
number = "10",
pages = "2029-2035",
doi = "10.1515/cclm-2013-0109"
}

Dobrić, M., Giga, V., Beleslin, B., Ignjatović, S., Paunović, I., Stepanović, J. M., Đorđević-Dikić, A., Kostić, J., Nedeljković, I., Nedeljković, M., Tesić, M., Dajak, M.,& Ostojić, M.. (2013). Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 51(10), 2029-2035.
https://doi.org/10.1515/cclm-2013-0109

Dobrić M, Giga V, Beleslin B, Ignjatović S, Paunović I, Stepanović JM, Đorđević-Dikić A, Kostić J, Nedeljković I, Nedeljković M, Tesić M, Dajak M, Ostojić M. Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test. in Clinical Chemistry and Laboratory Medicine. 2013;51(10):2029-2035.
doi:10.1515/cclm-2013-0109 .

Dobrić, Milan, Giga, Vojislav, Beleslin, Branko, Ignjatović, Svetlana, Paunović, Ivana, Stepanović, Jelena M., Đorđević-Dikić, Ana, Kostić, Jelena, Nedeljković, Ivana, Nedeljković, Milan, Tesić, Milorad, Dajak, Marijana, Ostojić, Miodrag, "Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test" in Clinical Chemistry and Laboratory Medicine, 51, no. 10 (2013):2029-2035,
https://doi.org/10.1515/cclm-2013-0109 . .