TY  - JOUR
AU  - Radović, Ana
AU  - Milinković, Neda
AU  - Stošović, Milan
AU  - Dopsaj, Violeta
AU  - Ignjatović, Svetlana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3566
AB  - Literature data indicate that increased uric acid (UA) levels are an important risk factor for cardiovascular disease. The aim of this study was to examine the association of  UA with cardiovascular risk factors in patients with hemodialysis using retrospective analysis. In 110 patients,  we  studied  the  values  of  basic  renal  function  parameters,  bone  metabolism  and cardiovascular risk factors in the period from 2010 to 2017. The results indicate a significant increase in urea (P=0.004), creatinine (P=0.028) and inorganic phosphate (P=0.001), as well as significant differences in gender (P=0.013), in risk categories defined on the basis of the UA decision  limit  (cut  off  <350  μmol/L).  After  controlling  the  effects  of  most  parameters, statistically  significant  correlation  coefficients  were  obtained  for  UA  and  urea  (r=0.361; P=0.0013),  creatinine  (r=0.388;  P=0.0005)  and  inorganic  phosphate  (r=0.366;  P=0.0011). Significant regression coefficients were obtained for UA and male gender (β=-0.227, P=0.004), age (β=-0.298, P˂0.001), urea (β=0.271, P=0.005) and inorganic phosphate (β=0.232, P=0.009). The  predictive  value  of  independent  parameters  in  relation  to  UA  was  confirmed  for  male gender  (OR=3.595;  95%  CI:  1.421-9.094;  P=0.007)  and  inorganic  phosphate  (OR=14.842; 2.518-87.472, P=0.003). By Cox regression analysis of proportional hazard ratio, we obtained the most significant combined effect of the body mass index, dialysis and diastolic pressure on UA concentration in relation to the duration of hemodialysis (P <0.0001). The results of this long-term  study  suggest  that  UA  can  not  be  considered  an  independent  cardiovascular  risk factor, but that HD patients need to strategically control the level of MK in order to reduce the resulting complications, morbidity and mortality.
AB  - Literaturni  podaci  ukazuju  da  povećana  koncentracija  mokraćne  kiseline  (MK) predstavlja  značajan  faktor  rizika  za  kardiovaskularne  bolesti.  Cilj  ove  studije  bio  je  da  se retrospektivnom analizom ispita povezanost MK sa faktorima rizika za kardiovaskularne bolesti kod bolesnika na hemodijalizi. Za 110 bolesnika analizirane su vrednosti osnovnih parametara funkcije bubrega, metabolizma kostiju i faktora rizika za kardiovaskularne bolesti u periodu od 2010. do 2017. godine. Rezultati ukazuju na značajno povećanje koncentracije uree (P=0,004), kreatinina (P=0,028) i neorganskog fosfata (P˂0,001), kao i značajne razlike u zavisnosti od pola (P=0,013) u kategorijama rizika definisanim na osnovu granične koncentracije MK (cut off <350  μmol/L).  Nakon  kontrolisanja  efekta  većine  parametara,  statistički  značajne  vrednosti koeficijenata  korelacije  dobijene  su  za  MK  i  ureu  (r=0,361;  P=0,0013),  kreatinin  (r=0,388; P=0,0005) i neorganski fosfat (r=0,366; P=0,0011). Značajni regresioni koeficijenti su dobijeni za MK i muški pol (β=-0,227, P=0,004), godine starosti (β=-0,298, P˂0,001), ureu (β=0,271, P=0,005) i neorganski fosfat (β=0,232, P=0,009). Prediktivna vrednost nezavisnih parametara u odnosu  na  MK  je  potvrđena  za  muški  pol  (OR=3,595;  95%  CI:  1,421-9,094;  P=0,007)  i neorganski  fosfat  (OR=14,842;  95%  CI:  2,518-87,472,  P=0,003).  Cox-ovom  regresijom proporcionalnih  nepoželjnih  ishoda  dobijen  je  najznačajniji  udruženi  efekat  indeksa  telesne mase  i  adekvatnosti  dijalize  na  koncentraciju  MK  u  odnosu  na  dužinu  trajanja  hemodijalize (P<0,0001). Rezultati ove dugoročne studije ukazuju da se MK ne može smatrati nezavisnim faktorom rizika za kardiovaskularne bolesti, ali da je kod bolesnika na HD, potrebno strateški kontrolisati nivo MK u cilju smanjenja posledičnih komplikacija, morbiditeta i mortaliteta.
PB  - Beograd: Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis
T1  - Povezanost koncentracije mokraćne kiseline sa tradicionalnim i ne-tradicionalnim faktorima rizika za kardiovaskularne bolesti kod bolesnika na hemodijalizi – retrospektivna analiza
VL  - 69
IS  - 5
SP  - 323
EP  - 337
DO  - 10.5937/arhfarm1905323R
ER  - 

@article{
author = "Radović, Ana and Milinković, Neda and Stošović, Milan and Dopsaj, Violeta and Ignjatović, Svetlana",
year = "2019",
abstract = "Literature data indicate that increased uric acid (UA) levels are an important risk factor for cardiovascular disease. The aim of this study was to examine the association of  UA with cardiovascular risk factors in patients with hemodialysis using retrospective analysis. In 110 patients,  we  studied  the  values  of  basic  renal  function  parameters,  bone  metabolism  and cardiovascular risk factors in the period from 2010 to 2017. The results indicate a significant increase in urea (P=0.004), creatinine (P=0.028) and inorganic phosphate (P=0.001), as well as significant differences in gender (P=0.013), in risk categories defined on the basis of the UA decision  limit  (cut  off  <350  μmol/L).  After  controlling  the  effects  of  most  parameters, statistically  significant  correlation  coefficients  were  obtained  for  UA  and  urea  (r=0.361; P=0.0013),  creatinine  (r=0.388;  P=0.0005)  and  inorganic  phosphate  (r=0.366;  P=0.0011). Significant regression coefficients were obtained for UA and male gender (β=-0.227, P=0.004), age (β=-0.298, P˂0.001), urea (β=0.271, P=0.005) and inorganic phosphate (β=0.232, P=0.009). The  predictive  value  of  independent  parameters  in  relation  to  UA  was  confirmed  for  male gender  (OR=3.595;  95%  CI:  1.421-9.094;  P=0.007)  and  inorganic  phosphate  (OR=14.842; 2.518-87.472, P=0.003). By Cox regression analysis of proportional hazard ratio, we obtained the most significant combined effect of the body mass index, dialysis and diastolic pressure on UA concentration in relation to the duration of hemodialysis (P <0.0001). The results of this long-term  study  suggest  that  UA  can  not  be  considered  an  independent  cardiovascular  risk factor, but that HD patients need to strategically control the level of MK in order to reduce the resulting complications, morbidity and mortality., Literaturni  podaci  ukazuju  da  povećana  koncentracija  mokraćne  kiseline  (MK) predstavlja  značajan  faktor  rizika  za  kardiovaskularne  bolesti.  Cilj  ove  studije  bio  je  da  se retrospektivnom analizom ispita povezanost MK sa faktorima rizika za kardiovaskularne bolesti kod bolesnika na hemodijalizi. Za 110 bolesnika analizirane su vrednosti osnovnih parametara funkcije bubrega, metabolizma kostiju i faktora rizika za kardiovaskularne bolesti u periodu od 2010. do 2017. godine. Rezultati ukazuju na značajno povećanje koncentracije uree (P=0,004), kreatinina (P=0,028) i neorganskog fosfata (P˂0,001), kao i značajne razlike u zavisnosti od pola (P=0,013) u kategorijama rizika definisanim na osnovu granične koncentracije MK (cut off <350  μmol/L).  Nakon  kontrolisanja  efekta  većine  parametara,  statistički  značajne  vrednosti koeficijenata  korelacije  dobijene  su  za  MK  i  ureu  (r=0,361;  P=0,0013),  kreatinin  (r=0,388; P=0,0005) i neorganski fosfat (r=0,366; P=0,0011). Značajni regresioni koeficijenti su dobijeni za MK i muški pol (β=-0,227, P=0,004), godine starosti (β=-0,298, P˂0,001), ureu (β=0,271, P=0,005) i neorganski fosfat (β=0,232, P=0,009). Prediktivna vrednost nezavisnih parametara u odnosu  na  MK  je  potvrđena  za  muški  pol  (OR=3,595;  95%  CI:  1,421-9,094;  P=0,007)  i neorganski  fosfat  (OR=14,842;  95%  CI:  2,518-87,472,  P=0,003).  Cox-ovom  regresijom proporcionalnih  nepoželjnih  ishoda  dobijen  je  najznačajniji  udruženi  efekat  indeksa  telesne mase  i  adekvatnosti  dijalize  na  koncentraciju  MK  u  odnosu  na  dužinu  trajanja  hemodijalize (P<0,0001). Rezultati ove dugoročne studije ukazuju da se MK ne može smatrati nezavisnim faktorom rizika za kardiovaskularne bolesti, ali da je kod bolesnika na HD, potrebno strateški kontrolisati nivo MK u cilju smanjenja posledičnih komplikacija, morbiditeta i mortaliteta.",
publisher = "Beograd: Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis, Povezanost koncentracije mokraćne kiseline sa tradicionalnim i ne-tradicionalnim faktorima rizika za kardiovaskularne bolesti kod bolesnika na hemodijalizi – retrospektivna analiza",
volume = "69",
number = "5",
pages = "323-337",
doi = "10.5937/arhfarm1905323R"
}

Radović, A., Milinković, N., Stošović, M., Dopsaj, V.,& Ignjatović, S.. (2019). The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis. in Arhiv za farmaciju
Beograd: Savez farmaceutskih udruženja Srbije., 69(5), 323-337.
https://doi.org/10.5937/arhfarm1905323R

Radović A, Milinković N, Stošović M, Dopsaj V, Ignjatović S. The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis. in Arhiv za farmaciju. 2019;69(5):323-337.
doi:10.5937/arhfarm1905323R .

Radović, Ana, Milinković, Neda, Stošović, Milan, Dopsaj, Violeta, Ignjatović, Svetlana, "The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis" in Arhiv za farmaciju, 69, no. 5 (2019):323-337,
https://doi.org/10.5937/arhfarm1905323R . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kravljača, Milica
AU  - Stošović, Milan
AU  - Savić, Jasna
AU  - Gojković, Tamara
AU  - Stefanović, Aleksan
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2121
AB  - Dyslipidemia is a common metabolic disorder in chronic kidney disease (CKD) and is largely responsible for development of cardiovascular complications in these patients. It has been noticed that characteristics of lipid disorders vary according to the degree of renal failure. In this study, we investigated concentrations of cholesterol and apolipoprotein B in small, dense low-density lipoproteins (sdLDL-C and sdLDL-apoB) in pre-dialysis (PD) and hemodialysis (HD) stage of CKD. In addition, we explored independent contribution of sdLDL-C and sdLDL-apoB to progression of CKD. We recruited 38 PD and 41 HD patients in this study. Concentrations of sdLDL-C and sdLDL-apoB were determined by heparin-magnesium precipitation method. Other biochemical parameters were measured by routine laboratory methods. Concentrations of sdLDL-C and sdLDL-apoB were significantly higher in PD than in HD patients (P lt 0,001). SdLDL-C (OR=0,122; P lt 0,001) and sdLDL-apoB (OR=0,109; P lt 0,001) were identified as predictors of progression of CKD towards HD stage. Both of examined parameters were independently associated with the disease progression after adjustment for other lipid and non-lipid risk markers, with an exception for adjustment for urea concentration. Assessment of sdLDL-C and sdLDL-apoB in different stages of CKD could be beneficial in term of prediction of risk for cardiovascular disease development and prediction of progression of CKD itself.
AB  - Dislipidemija je uobičajen metabolički poremećaj u hroničnoj bubrežnoj bolesti (HBB) i u velikoj meri je odgovorna za nastanak kasnijih kardiovaskularnih komplikacija kod ovih pacijenata. Uočeno je da karakteristike dislipidemije variraju u zavisnosti od stadijuma HBB. U ovom radu ispitivali smo koncentracije holesterola i apolipoproteina B u malim, gustim česticama lipoproteina niske gustine (sdLDL-h i sdLDL-apoB) u predijaliznom (PD) i hemodijaliznom (HD) stadijumu HBB, kao i njihov nezavisni potencijal u predviđanju progresije HBB. U studiji je učestvovalo 38 PD i 41 HD pacijent. Koncentracije sdLDL-h i sdLDL-apoB određene su nakon selektivne precipitacije sa heparinom i Mg-solima, a koncentracije ostalih biohemijskih parametara rutinskim metodama. Koncentracije sdLDL-h i sdLDL-apoB bile su značajno više kod PD u odnosu na HD pacijente (P lt 0,001). SdLDL-h (OR=0,122; P lt 0,001) i sdLDL-apoB (OR=0,109; P lt 0,001) identifikovani su kao značajni prediktori progresije bolesti od PD do HD stadijuma, a nezavisan prediktivni potencijal zadržali su i u prisustvu drugih lipidnih i nelipidnih faktora rizika, osim uree. Određivanje sdLDL-h i sdLDL-apoB kod pacijenata u različitim stadijumima HBB može biti korisno u smislu predviđanja rizika za nastanak aterosklerotskih promena, kao i predviđanja progresije same HBB.
PB  - Most Art doo, Beograd
T2  - MD - Medical data
T1  - The role of small, dense LDL cholesterol in progression of chronic kidney disease
T1  - Uloga holesterola u malim, gustim LDL česticama u progresiji hronične bubrežne bolesti
VL  - 6
IS  - 3
SP  - 253
EP  - 257
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2121
ER  - 

@article{
author = "Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Kravljača, Milica and Stošović, Milan and Savić, Jasna and Gojković, Tamara and Stefanović, Aleksan",
year = "2014",
abstract = "Dyslipidemia is a common metabolic disorder in chronic kidney disease (CKD) and is largely responsible for development of cardiovascular complications in these patients. It has been noticed that characteristics of lipid disorders vary according to the degree of renal failure. In this study, we investigated concentrations of cholesterol and apolipoprotein B in small, dense low-density lipoproteins (sdLDL-C and sdLDL-apoB) in pre-dialysis (PD) and hemodialysis (HD) stage of CKD. In addition, we explored independent contribution of sdLDL-C and sdLDL-apoB to progression of CKD. We recruited 38 PD and 41 HD patients in this study. Concentrations of sdLDL-C and sdLDL-apoB were determined by heparin-magnesium precipitation method. Other biochemical parameters were measured by routine laboratory methods. Concentrations of sdLDL-C and sdLDL-apoB were significantly higher in PD than in HD patients (P lt 0,001). SdLDL-C (OR=0,122; P lt 0,001) and sdLDL-apoB (OR=0,109; P lt 0,001) were identified as predictors of progression of CKD towards HD stage. Both of examined parameters were independently associated with the disease progression after adjustment for other lipid and non-lipid risk markers, with an exception for adjustment for urea concentration. Assessment of sdLDL-C and sdLDL-apoB in different stages of CKD could be beneficial in term of prediction of risk for cardiovascular disease development and prediction of progression of CKD itself., Dislipidemija je uobičajen metabolički poremećaj u hroničnoj bubrežnoj bolesti (HBB) i u velikoj meri je odgovorna za nastanak kasnijih kardiovaskularnih komplikacija kod ovih pacijenata. Uočeno je da karakteristike dislipidemije variraju u zavisnosti od stadijuma HBB. U ovom radu ispitivali smo koncentracije holesterola i apolipoproteina B u malim, gustim česticama lipoproteina niske gustine (sdLDL-h i sdLDL-apoB) u predijaliznom (PD) i hemodijaliznom (HD) stadijumu HBB, kao i njihov nezavisni potencijal u predviđanju progresije HBB. U studiji je učestvovalo 38 PD i 41 HD pacijent. Koncentracije sdLDL-h i sdLDL-apoB određene su nakon selektivne precipitacije sa heparinom i Mg-solima, a koncentracije ostalih biohemijskih parametara rutinskim metodama. Koncentracije sdLDL-h i sdLDL-apoB bile su značajno više kod PD u odnosu na HD pacijente (P lt 0,001). SdLDL-h (OR=0,122; P lt 0,001) i sdLDL-apoB (OR=0,109; P lt 0,001) identifikovani su kao značajni prediktori progresije bolesti od PD do HD stadijuma, a nezavisan prediktivni potencijal zadržali su i u prisustvu drugih lipidnih i nelipidnih faktora rizika, osim uree. Određivanje sdLDL-h i sdLDL-apoB kod pacijenata u različitim stadijumima HBB može biti korisno u smislu predviđanja rizika za nastanak aterosklerotskih promena, kao i predviđanja progresije same HBB.",
publisher = "Most Art doo, Beograd",
journal = "MD - Medical data",
title = "The role of small, dense LDL cholesterol in progression of chronic kidney disease, Uloga holesterola u malim, gustim LDL česticama u progresiji hronične bubrežne bolesti",
volume = "6",
number = "3",
pages = "253-257",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2121"
}

Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Vekić, J., Spasojević-Kalimanovska, V., Kravljača, M., Stošović, M., Savić, J., Gojković, T.,& Stefanović, A.. (2014). The role of small, dense LDL cholesterol in progression of chronic kidney disease. in MD - Medical data
Most Art doo, Beograd., 6(3), 253-257.
https://hdl.handle.net/21.15107/rcub_farfar_2121

Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Vekić J, Spasojević-Kalimanovska V, Kravljača M, Stošović M, Savić J, Gojković T, Stefanović A. The role of small, dense LDL cholesterol in progression of chronic kidney disease. in MD - Medical data. 2014;6(3):253-257.
https://hdl.handle.net/21.15107/rcub_farfar_2121 .

Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Kravljača, Milica, Stošović, Milan, Savić, Jasna, Gojković, Tamara, Stefanović, Aleksan, "The role of small, dense LDL cholesterol in progression of chronic kidney disease" in MD - Medical data, 6, no. 3 (2014):253-257,
https://hdl.handle.net/21.15107/rcub_farfar_2121 .

TY  - JOUR
AU  - Savić, Jasna
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Gojković, Tamara
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2126
AB  - Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.
PB  - Informa Healthcare, London
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease
VL  - 74
IS  - 7
SP  - 637
EP  - 643
DO  - 10.3109/00365513.2014.928944
ER  - 

@article{
author = "Savić, Jasna and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Stošović, Milan and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Gojković, Tamara and Spasić, Slavica",
year = "2014",
abstract = "Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.",
publisher = "Informa Healthcare, London",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease",
volume = "74",
number = "7",
pages = "637-643",
doi = "10.3109/00365513.2014.928944"
}

Savić, J., Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M., Stošović, M., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Gojković, T.,& Spasić, S.. (2014). Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation
Informa Healthcare, London., 74(7), 637-643.
https://doi.org/10.3109/00365513.2014.928944

Savić J, Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Stošović M, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Gojković T, Spasić S. Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(7):637-643.
doi:10.3109/00365513.2014.928944 .

Savić, Jasna, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Stošović, Milan, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Gojković, Tamara, Spasić, Slavica, "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 7 (2014):637-643,
https://doi.org/10.3109/00365513.2014.928944 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Bogavac-Stanojević, Nataša
AU  - Vucković, Maja
AU  - Dopsaj, Violeta
AU  - Giga, Vojislav
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1719
AB  - The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation
VL  - 226
IS  - 2
SP  - 137
EP  - 144
DO  - 10.1620/tjem.226.137
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Bogavac-Stanojević, Nataša and Vucković, Maja and Dopsaj, Violeta and Giga, Vojislav and Kravljaca, Milica and Stošović, Milan and Lezaić, Višnja",
year = "2012",
abstract = "The best treatment for end stage renal disease (ESRD) patients is kidney transplantation, but the renal transplant recipients still have a higher incidence of cardiovascular events compared with general population. Cardiovascular risk factors were imposed long before ESRD, as the majority of patients starting dialysis or kidney transplantation already have signs of advanced atherosclerosis. Artery calcification is an organized, regulated process similar to bone formation. Coronary artery calcification (CAC) is found frequently in advanced atherosclerotic lesions and could be a useful marker of them. We evaluated the prevalence of CAC in 49 stable renal transplant recipients and in 48 age- and gender-matched patients with chronic kidney disease (CKD) in stages 2-5 not requiring dialysis to assess risk factors associated with CAC. Computed tomography was used for CAC detection and quantification (CAC score). The prevalence of CAC was 43.8% in transplant recipients and 16.7% in CKD patients (p  lt  0.001). Transplant recipients with CAC were significantly older and had longer duration of CKD and/or dialysis than recipients without CAC. In contrast, the serum levels of fetuin A (an inhibitor of vascular calcification) and albumin were significantly lower in CKD patients with CAC than those without CAC. During the observation period (30 months), 30 patients, including 23 CKD patients, began dialysis, and 4 transplant recipients and 2 CKD patients died. Independent predictors of mortality were age, serum amyloid A and the CAC score. In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation",
volume = "226",
number = "2",
pages = "137-144",
doi = "10.1620/tjem.226.137"
}

Simić-Ogrizović, S., Bogavac-Stanojević, N., Vucković, M., Dopsaj, V., Giga, V., Kravljaca, M., Stošović, M.,& Lezaić, V.. (2012). Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 226(2), 137-144.
https://doi.org/10.1620/tjem.226.137

Simić-Ogrizović S, Bogavac-Stanojević N, Vucković M, Dopsaj V, Giga V, Kravljaca M, Stošović M, Lezaić V. Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation. in Toxicological and Environmental Chemistry. 2012;226(2):137-144.
doi:10.1620/tjem.226.137 .

Simić-Ogrizović, Sanja, Bogavac-Stanojević, Nataša, Vucković, Maja, Dopsaj, Violeta, Giga, Vojislav, Kravljaca, Milica, Stošović, Milan, Lezaić, Višnja, "Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation" in Toxicological and Environmental Chemistry, 226, no. 2 (2012):137-144,
https://doi.org/10.1620/tjem.226.137 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Jovanović, D.
AU  - Dopsaj, Violeta
AU  - Radović, M.
AU  - Šumarac, Zorica
AU  - Bogavac-Stanojević, Nataša
AU  - Stošović, Milan
AU  - Stanojević, M.
AU  - Nesić, V.
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1251
AB  - The aims of the present study were to determine the prevalence of depression in our dialysis patients, to detect the most powerful variables associated with depression, and to determine the role of depression in prediction of mortality. The prospective follow-up study of 128 patients (77 HD and 51 CAPD, 65 male, aged 53.8 +/- 13.5 years, dialysis duration 64.7 +/- 64.8 months) was carried out over 3 6 months. Depression by the Beck Depression Inventory-BDI-II score, laboratory parameters (hemoglobin, serum albumin and creatinine concentration), immunological status (cytokines and hsCRP), comorbidity by Index of Physical Impairment (IPI) and adequacy of dialysis by Kt/V were monitored. The overall prevalence of depression in the dialysis patients (BDI score >= 14) was 45.3%, and 28.2%, respectively, for moderate and severe depression (BDI >= 20). The most powerful variable associated with depression was IL-6, but associations with albumin, hemoglobin, creatinine and IPI score were also found. During the follow-up period 36 patients died, 7 patients left the cohort and 2 patients were transplanted. If IPI score was not included in the multivariate Cox analysis, the BDI score remained one of the best predictors of mortality along with albumin. In conclusion, because of the close association of depression with inflammation, malnutrition, and cardiovascular mortality, it could be speculated that depression is one branch of the MIA (malnutrition, inflammation, atherosclerosis) syndrome.
PB  - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
T2  - Clinical Nephrology
T1  - Could depression be a new branch of MIA syndrome?
VL  - 71
IS  - 2
SP  - 164
EP  - 172
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1251
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Jovanović, D. and Dopsaj, Violeta and Radović, M. and Šumarac, Zorica and Bogavac-Stanojević, Nataša and Stošović, Milan and Stanojević, M. and Nesić, V.",
year = "2009",
abstract = "The aims of the present study were to determine the prevalence of depression in our dialysis patients, to detect the most powerful variables associated with depression, and to determine the role of depression in prediction of mortality. The prospective follow-up study of 128 patients (77 HD and 51 CAPD, 65 male, aged 53.8 +/- 13.5 years, dialysis duration 64.7 +/- 64.8 months) was carried out over 3 6 months. Depression by the Beck Depression Inventory-BDI-II score, laboratory parameters (hemoglobin, serum albumin and creatinine concentration), immunological status (cytokines and hsCRP), comorbidity by Index of Physical Impairment (IPI) and adequacy of dialysis by Kt/V were monitored. The overall prevalence of depression in the dialysis patients (BDI score >= 14) was 45.3%, and 28.2%, respectively, for moderate and severe depression (BDI >= 20). The most powerful variable associated with depression was IL-6, but associations with albumin, hemoglobin, creatinine and IPI score were also found. During the follow-up period 36 patients died, 7 patients left the cohort and 2 patients were transplanted. If IPI score was not included in the multivariate Cox analysis, the BDI score remained one of the best predictors of mortality along with albumin. In conclusion, because of the close association of depression with inflammation, malnutrition, and cardiovascular mortality, it could be speculated that depression is one branch of the MIA (malnutrition, inflammation, atherosclerosis) syndrome.",
publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen",
journal = "Clinical Nephrology",
title = "Could depression be a new branch of MIA syndrome?",
volume = "71",
number = "2",
pages = "164-172",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1251"
}

Simić-Ogrizović, S., Jovanović, D., Dopsaj, V., Radović, M., Šumarac, Z., Bogavac-Stanojević, N., Stošović, M., Stanojević, M.,& Nesić, V.. (2009). Could depression be a new branch of MIA syndrome?. in Clinical Nephrology
Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 71(2), 164-172.
https://hdl.handle.net/21.15107/rcub_farfar_1251

Simić-Ogrizović S, Jovanović D, Dopsaj V, Radović M, Šumarac Z, Bogavac-Stanojević N, Stošović M, Stanojević M, Nesić V. Could depression be a new branch of MIA syndrome?. in Clinical Nephrology. 2009;71(2):164-172.
https://hdl.handle.net/21.15107/rcub_farfar_1251 .

Simić-Ogrizović, Sanja, Jovanović, D., Dopsaj, Violeta, Radović, M., Šumarac, Zorica, Bogavac-Stanojević, Nataša, Stošović, Milan, Stanojević, M., Nesić, V., "Could depression be a new branch of MIA syndrome?" in Clinical Nephrology, 71, no. 2 (2009):164-172,
https://hdl.handle.net/21.15107/rcub_farfar_1251 .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Dopsaj, Violeta
AU  - Bogavac-Stanojević, Nataša
AU  - Obradović, Ivana
AU  - Stošović, Milan
AU  - Radović, Milan
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1177
AB  - The most frequent cause of death in hemodialysis patients is cardiovascular disease with chronic inflammation being an epidemiologically proved risk factor. Many studies have shown C-reactive protein (CRP) as the strongest predictor of long-term mortality of hemodialysis patients, while other reports have indicated acute phase proteins as potential predictors of the mortality. The present study therefore aimed to evaluate the prevalence of chronic inflammation in hemodialysis patients and the role of acute phase proteins together with lipids and divalent ions for predicting mortality in hemodialysis patients. Chronic inflammation was defined, based on the serum level of high sensitive CRIP > 8.4 mg/L and/or serum amyloid-A (SAA) > 8.9 mg/L. Acute phase proteins are defined as one whose plasma concentration increase (positive) or decreases (negative) by at least 25% during inflammation. High sensitive CRIP and SAA were positive acute phase proteins measured, while albumin and fetuin-A, a calcification inhibitor, were selected as negative acute phase proteins. This prospective 36-month follow-up study included 130 patients (60 males and 70 females, aged 55.1 +/- 12.9 years) maintained by hemodialysis for 107.2 +/- 54.72 months at a Nephrology Clinic in Belgrade. The prevalence of chronic inflammation was 35.4% (46 patients). During the follow-up period, 24 patients (18.5%) died and 2 patients received transplants. In multivariate analysis, potential independent predictors of mortality in hemodialysis patients are hyperphosphatemia, hypoalbuminemia, and high SAA. Considering that assays for SAA are widely used, we propose that SAA is the best predictor for outcomes of end-stage renal disease.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Serum Amyloid-A Rather Than C-Reactive Protein Is a Better Predictor of Mortality in Hemodialysis Patients
VL  - 219
IS  - 2
SP  - 121
EP  - 127
DO  - 10.1620/tjem.219.121
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Dopsaj, Violeta and Bogavac-Stanojević, Nataša and Obradović, Ivana and Stošović, Milan and Radović, Milan",
year = "2009",
abstract = "The most frequent cause of death in hemodialysis patients is cardiovascular disease with chronic inflammation being an epidemiologically proved risk factor. Many studies have shown C-reactive protein (CRP) as the strongest predictor of long-term mortality of hemodialysis patients, while other reports have indicated acute phase proteins as potential predictors of the mortality. The present study therefore aimed to evaluate the prevalence of chronic inflammation in hemodialysis patients and the role of acute phase proteins together with lipids and divalent ions for predicting mortality in hemodialysis patients. Chronic inflammation was defined, based on the serum level of high sensitive CRIP > 8.4 mg/L and/or serum amyloid-A (SAA) > 8.9 mg/L. Acute phase proteins are defined as one whose plasma concentration increase (positive) or decreases (negative) by at least 25% during inflammation. High sensitive CRIP and SAA were positive acute phase proteins measured, while albumin and fetuin-A, a calcification inhibitor, were selected as negative acute phase proteins. This prospective 36-month follow-up study included 130 patients (60 males and 70 females, aged 55.1 +/- 12.9 years) maintained by hemodialysis for 107.2 +/- 54.72 months at a Nephrology Clinic in Belgrade. The prevalence of chronic inflammation was 35.4% (46 patients). During the follow-up period, 24 patients (18.5%) died and 2 patients received transplants. In multivariate analysis, potential independent predictors of mortality in hemodialysis patients are hyperphosphatemia, hypoalbuminemia, and high SAA. Considering that assays for SAA are widely used, we propose that SAA is the best predictor for outcomes of end-stage renal disease.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Serum Amyloid-A Rather Than C-Reactive Protein Is a Better Predictor of Mortality in Hemodialysis Patients",
volume = "219",
number = "2",
pages = "121-127",
doi = "10.1620/tjem.219.121"
}

Simić-Ogrizović, S., Dopsaj, V., Bogavac-Stanojević, N., Obradović, I., Stošović, M.,& Radović, M.. (2009). Serum Amyloid-A Rather Than C-Reactive Protein Is a Better Predictor of Mortality in Hemodialysis Patients. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 219(2), 121-127.
https://doi.org/10.1620/tjem.219.121

Simić-Ogrizović S, Dopsaj V, Bogavac-Stanojević N, Obradović I, Stošović M, Radović M. Serum Amyloid-A Rather Than C-Reactive Protein Is a Better Predictor of Mortality in Hemodialysis Patients. in Toxicological and Environmental Chemistry. 2009;219(2):121-127.
doi:10.1620/tjem.219.121 .

Simić-Ogrizović, Sanja, Dopsaj, Violeta, Bogavac-Stanojević, Nataša, Obradović, Ivana, Stošović, Milan, Radović, Milan, "Serum Amyloid-A Rather Than C-Reactive Protein Is a Better Predictor of Mortality in Hemodialysis Patients" in Toxicological and Environmental Chemistry, 219, no. 2 (2009):121-127,
https://doi.org/10.1620/tjem.219.121 . .