TY  - JOUR
AU  - Tadić, Ivana
AU  - Žuža, Olivera
AU  - Žujović, Dejan
AU  - Agić, Anita
AU  - Korčok, Davor
AU  - Lazović, Biljana
AU  - Stevanović, Dejan
AU  - Đorđević, Brižita
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5408
AB  - Objectives: Evidence suggests that both N-Acetyl-L-cysteine (NAC) and NAC in combination with propolis (NAC-P) reduce symptoms of acute bronchitis and improve Health-Related Quality of Life (HRQoL). This study aimed to compare the impact of NAC and NAC-P therapy on acute bronchitis patients' quality of life. Design, setting, and subjects: A randomized, single-blind parallel-group study was achieved at Municipal Institute for Lung Diseases and Tuberculosis Medical Centre, Belgrade, Serbia. Patients with acute bronchitis were randomly assigned into two groups to receive NAC (200mg three times a day) or NAC-P (200mg+80mg three times a day) orally for a minimum of ten days. HRQoL of patients was measured twice (at two appointments) using the Leicester Cough Questionnaire (LCQ) and EQ-5D questionnaires. Results: The study included 42 patients in the NAC-P group and 43 in the NAC group. The correlation between the LCQ total score and Health State Values (HSV) was positive and statistically significant in the NAC-P and the NAC groups at the second appointment. The differences between values of EQ-5D scores were slightly higher (but not statistically significant) in the NAC-P group compared to the NAC group, indicating a more remarkable improvement of HRQoL using NAC-P. Conclusion: NAC-P and NAC may improve HRQoL in patients with acute bronchitis. EQ-5D scale values indicated that NAC-P might improve quality of life more than NAC. Our results may provide the basis for better decision-making by healthcare professionals when choosing the right therapy.
PB  - Association of Pharmaceutical Teachers of India
T2  - Indian Journal of Pharmaceutical Education and Research
T1  - The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis
VL  - 58
IS  - 1
SP  - 348
EP  - 354
DO  - 10.5530/ijper.58.1.38
ER  - 

@article{
author = "Tadić, Ivana and Žuža, Olivera and Žujović, Dejan and Agić, Anita and Korčok, Davor and Lazović, Biljana and Stevanović, Dejan and Đorđević, Brižita",
year = "2024",
abstract = "Objectives: Evidence suggests that both N-Acetyl-L-cysteine (NAC) and NAC in combination with propolis (NAC-P) reduce symptoms of acute bronchitis and improve Health-Related Quality of Life (HRQoL). This study aimed to compare the impact of NAC and NAC-P therapy on acute bronchitis patients' quality of life. Design, setting, and subjects: A randomized, single-blind parallel-group study was achieved at Municipal Institute for Lung Diseases and Tuberculosis Medical Centre, Belgrade, Serbia. Patients with acute bronchitis were randomly assigned into two groups to receive NAC (200mg three times a day) or NAC-P (200mg+80mg three times a day) orally for a minimum of ten days. HRQoL of patients was measured twice (at two appointments) using the Leicester Cough Questionnaire (LCQ) and EQ-5D questionnaires. Results: The study included 42 patients in the NAC-P group and 43 in the NAC group. The correlation between the LCQ total score and Health State Values (HSV) was positive and statistically significant in the NAC-P and the NAC groups at the second appointment. The differences between values of EQ-5D scores were slightly higher (but not statistically significant) in the NAC-P group compared to the NAC group, indicating a more remarkable improvement of HRQoL using NAC-P. Conclusion: NAC-P and NAC may improve HRQoL in patients with acute bronchitis. EQ-5D scale values indicated that NAC-P might improve quality of life more than NAC. Our results may provide the basis for better decision-making by healthcare professionals when choosing the right therapy.",
publisher = "Association of Pharmaceutical Teachers of India",
journal = "Indian Journal of Pharmaceutical Education and Research",
title = "The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis",
volume = "58",
number = "1",
pages = "348-354",
doi = "10.5530/ijper.58.1.38"
}

Tadić, I., Žuža, O., Žujović, D., Agić, A., Korčok, D., Lazović, B., Stevanović, D.,& Đorđević, B.. (2024). The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis. in Indian Journal of Pharmaceutical Education and Research
Association of Pharmaceutical Teachers of India., 58(1), 348-354.
https://doi.org/10.5530/ijper.58.1.38

Tadić I, Žuža O, Žujović D, Agić A, Korčok D, Lazović B, Stevanović D, Đorđević B. The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis. in Indian Journal of Pharmaceutical Education and Research. 2024;58(1):348-354.
doi:10.5530/ijper.58.1.38 .

Tadić, Ivana, Žuža, Olivera, Žujović, Dejan, Agić, Anita, Korčok, Davor, Lazović, Biljana, Stevanović, Dejan, Đorđević, Brižita, "The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis" in Indian Journal of Pharmaceutical Education and Research, 58, no. 1 (2024):348-354,
https://doi.org/10.5530/ijper.58.1.38 . .

TY  - JOUR
AU  - Ivanović, Nevena
AU  - Radosavljević, Branimir
AU  - Zeković, Milica
AU  - Korčok, Davor
AU  - Ignjatović, Svetlana
AU  - Đorđević, Brižita
AU  - Milinković, Neda
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4048
AB  - This study aimed to investigate the short-term effects of three magnesium (Mg) dietary supplements containing mineral immediately available for absorption on Mg biochemical status indices (ionized and total Mg), as well as their effects on electrolytes levels in healthy female young adults (n = 61). After a 10-days intervention period supplementation with powder/granulate containing Mg oxide led to an increase in both ionized Mg concentration and % in total Mg in comparison with the baseline. Supplementation with Mg citrate was associated with the significant increase in % of ionized fraction and decrease in serum total Mg concentration. By contrast, among participants consuming Mg carbonate in the form of effervescent tablets ionized Mg concentration and % in total Mg decreased, without detectable changes in serum total Mg. In conclusion, after the short-term supplementation period, Mg oxide demonstrated superior bioavailability compared to the other examined Mg supplements without affecting other minerals’ levels.
PB  - Springer Nature B.V.
T2  - BioMetals
T1  - Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels
VL  - 35
SP  - 267
EP  - 283
DO  - 10.1007/s10534-022-00363-y
ER  - 

@article{
author = "Ivanović, Nevena and Radosavljević, Branimir and Zeković, Milica and Korčok, Davor and Ignjatović, Svetlana and Đorđević, Brižita and Milinković, Neda",
year = "2022",
abstract = "This study aimed to investigate the short-term effects of three magnesium (Mg) dietary supplements containing mineral immediately available for absorption on Mg biochemical status indices (ionized and total Mg), as well as their effects on electrolytes levels in healthy female young adults (n = 61). After a 10-days intervention period supplementation with powder/granulate containing Mg oxide led to an increase in both ionized Mg concentration and % in total Mg in comparison with the baseline. Supplementation with Mg citrate was associated with the significant increase in % of ionized fraction and decrease in serum total Mg concentration. By contrast, among participants consuming Mg carbonate in the form of effervescent tablets ionized Mg concentration and % in total Mg decreased, without detectable changes in serum total Mg. In conclusion, after the short-term supplementation period, Mg oxide demonstrated superior bioavailability compared to the other examined Mg supplements without affecting other minerals’ levels.",
publisher = "Springer Nature B.V.",
journal = "BioMetals",
title = "Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels",
volume = "35",
pages = "267-283",
doi = "10.1007/s10534-022-00363-y"
}

Ivanović, N., Radosavljević, B., Zeković, M., Korčok, D., Ignjatović, S., Đorđević, B.,& Milinković, N.. (2022). Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels. in BioMetals
Springer Nature B.V.., 35, 267-283.
https://doi.org/10.1007/s10534-022-00363-y

Ivanović N, Radosavljević B, Zeković M, Korčok D, Ignjatović S, Đorđević B, Milinković N. Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels. in BioMetals. 2022;35:267-283.
doi:10.1007/s10534-022-00363-y .

Ivanović, Nevena, Radosavljević, Branimir, Zeković, Milica, Korčok, Davor, Ignjatović, Svetlana, Đorđević, Brižita, Milinković, Neda, "Effects of short-term magnesium supplementation on ionized, total magnesium and other relevant electrolytes levels" in BioMetals, 35 (2022):267-283,
https://doi.org/10.1007/s10534-022-00363-y . .

TY  - JOUR
AU  - Korčok, Davor J.
AU  - Tršić-Milanović, Nada
AU  - Ilić, Marija
AU  - Mitić, Bogdan
AU  - Đorđević, Brižita
AU  - Ivanović, Nevena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3820
AB  - In recent decades, probiotic products have been increasingly used to prevent certain gastrointestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters.
AB  - Probiotski proizvodi se poslednjih decenija sve više koriste za prevenciju određenih gastrointestinalnih i urogenitalnih poremećaja, za poboljšanje opšteg stanja organi-zma i kao dopuna farmakološke terapije. Najčešće su registrovani kao dijetetski suple-menti, a ređe kao lekovi u obliku kapsula, praškova i rastvora. Optimizacija tehnoloških procesa proizvodnje i pakovanje ovih proizvoda ima za cilj održavanje probiotskih karakteristika  uz istovremeno pridržavanje svih kriterijuma u toku proizvodnje koji osiguravaju kvalitet, biološku raspoloživost i optimalno terapijsko dejstvo U ovom radu razmatran je značaj izbora primarnog i sekundarnog materijala za pakovanje sa ciljem očuvanja vijabilnost probiotskih ćelija u kapsulama tokom dve godine tj. tokom roka upotrebe. Poređenjem primene PVC (polivinil hlorid) i PVC/poliviniliden  hlorid/poli-etilen (PVC/PVdC/PE) blister folija uočena je bolja zaštita probotskih ćelija od kiseonika i vlage primenom višeslojene folije. Dodatne efekte zaštite probiotskih ćelija u ovom radu potvrdjene su primenom dodatne zaštite blistera upotrebom sekundarnog pakovanja (engl. flow pack) kesice sa inertni gasom.
PB  - Association of the Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG
T1  - Unapređenje vijabilnosti i stabilnosti probiotskog proizvoda sa Saccharomyces boulardii DBVPG
VL  - 75
IS  - 1
SP  - 25
EP  - 30
DO  - 10.2298/HEMIND201211008K
ER  - 

@article{
author = "Korčok, Davor J. and Tršić-Milanović, Nada and Ilić, Marija and Mitić, Bogdan and Đorđević, Brižita and Ivanović, Nevena",
year = "2021",
abstract = "In recent decades, probiotic products have been increasingly used to prevent certain gastrointestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters., Probiotski proizvodi se poslednjih decenija sve više koriste za prevenciju određenih gastrointestinalnih i urogenitalnih poremećaja, za poboljšanje opšteg stanja organi-zma i kao dopuna farmakološke terapije. Najčešće su registrovani kao dijetetski suple-menti, a ređe kao lekovi u obliku kapsula, praškova i rastvora. Optimizacija tehnoloških procesa proizvodnje i pakovanje ovih proizvoda ima za cilj održavanje probiotskih karakteristika  uz istovremeno pridržavanje svih kriterijuma u toku proizvodnje koji osiguravaju kvalitet, biološku raspoloživost i optimalno terapijsko dejstvo U ovom radu razmatran je značaj izbora primarnog i sekundarnog materijala za pakovanje sa ciljem očuvanja vijabilnost probiotskih ćelija u kapsulama tokom dve godine tj. tokom roka upotrebe. Poređenjem primene PVC (polivinil hlorid) i PVC/poliviniliden  hlorid/poli-etilen (PVC/PVdC/PE) blister folija uočena je bolja zaštita probotskih ćelija od kiseonika i vlage primenom višeslojene folije. Dodatne efekte zaštite probiotskih ćelija u ovom radu potvrdjene su primenom dodatne zaštite blistera upotrebom sekundarnog pakovanja (engl. flow pack) kesice sa inertni gasom.",
publisher = "Association of the Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG, Unapređenje vijabilnosti i stabilnosti probiotskog proizvoda sa Saccharomyces boulardii DBVPG",
volume = "75",
number = "1",
pages = "25-30",
doi = "10.2298/HEMIND201211008K"
}

Korčok, D. J., Tršić-Milanović, N., Ilić, M., Mitić, B., Đorđević, B.,& Ivanović, N.. (2021). Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG. in Hemijska industrija
Association of the Chemical Engineers of Serbia., 75(1), 25-30.
https://doi.org/10.2298/HEMIND201211008K

Korčok DJ, Tršić-Milanović N, Ilić M, Mitić B, Đorđević B, Ivanović N. Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG. in Hemijska industrija. 2021;75(1):25-30.
doi:10.2298/HEMIND201211008K .

Korčok, Davor J., Tršić-Milanović, Nada, Ilić, Marija, Mitić, Bogdan, Đorđević, Brižita, Ivanović, Nevena, "Improving the viability and stability of a probiotic product with Saccharomyces boulardii DBVPG" in Hemijska industrija, 75, no. 1 (2021):25-30,
https://doi.org/10.2298/HEMIND201211008K . .