TY  - JOUR
AU  - Bogdanović, Mihajlo
AU  - Mladenović, Dragana
AU  - Mojović, Ljiljana
AU  - Đuriš, Jelena
AU  - Đukić-Vuković, Aleksandra
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5558
AB  - The last decade provided significant advances in the understanding of microbiota and its role in human health. Probiotics are live microorganisms with proven benefits for the host and were mostly studied in the context of gut health, but they can also confer significant benefits for oral health, mainly in the treatment of gingivitis. Postbiotics are cell-free extracts and metabolites of microorganisms which can provide additional preventive and therapeutic value for human health. This opens opportunities for new preventive or therapeutic formulations for oral administration. The microorganisms that colonize the oral cavity, their role in oral health and disease, as well as the probiotics and postbiotics which could have beneficial effects in this complex environment were discussed. The aim of this study was to review, analyse and discuss novel probiotic and postbiotic formulations intended for oral administration that could be of great preventive and therapeutic importance. A special attention has been put on the formulation of the pharmaceutical dosage forms that are expected to provide new benefits for the patients and technological advantages relevant for industry. An adequate dosage form could significantly enhance the efficiency of these products.
PB  - Faculdade de Ciencias Farmaceuticas
T2  - Brazilian Journal of Pharmaceutical Sciences
T1  - Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies
VL  - 60
DO  - 10.1590/s2175-97902024e23272
ER  - 

@article{
author = "Bogdanović, Mihajlo and Mladenović, Dragana and Mojović, Ljiljana and Đuriš, Jelena and Đukić-Vuković, Aleksandra",
year = "2024",
abstract = "The last decade provided significant advances in the understanding of microbiota and its role in human health. Probiotics are live microorganisms with proven benefits for the host and were mostly studied in the context of gut health, but they can also confer significant benefits for oral health, mainly in the treatment of gingivitis. Postbiotics are cell-free extracts and metabolites of microorganisms which can provide additional preventive and therapeutic value for human health. This opens opportunities for new preventive or therapeutic formulations for oral administration. The microorganisms that colonize the oral cavity, their role in oral health and disease, as well as the probiotics and postbiotics which could have beneficial effects in this complex environment were discussed. The aim of this study was to review, analyse and discuss novel probiotic and postbiotic formulations intended for oral administration that could be of great preventive and therapeutic importance. A special attention has been put on the formulation of the pharmaceutical dosage forms that are expected to provide new benefits for the patients and technological advantages relevant for industry. An adequate dosage form could significantly enhance the efficiency of these products.",
publisher = "Faculdade de Ciencias Farmaceuticas",
journal = "Brazilian Journal of Pharmaceutical Sciences",
title = "Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies",
volume = "60",
doi = "10.1590/s2175-97902024e23272"
}

Bogdanović, M., Mladenović, D., Mojović, L., Đuriš, J.,& Đukić-Vuković, A.. (2024). Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies. in Brazilian Journal of Pharmaceutical Sciences
Faculdade de Ciencias Farmaceuticas., 60.
https://doi.org/10.1590/s2175-97902024e23272

Bogdanović M, Mladenović D, Mojović L, Đuriš J, Đukić-Vuković A. Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies. in Brazilian Journal of Pharmaceutical Sciences. 2024;60.
doi:10.1590/s2175-97902024e23272 .

Bogdanović, Mihajlo, Mladenović, Dragana, Mojović, Ljiljana, Đuriš, Jelena, Đukić-Vuković, Aleksandra, "Intraoral administration of probiotics and postbiotics: An overview of microorganisms and formulation strategies" in Brazilian Journal of Pharmaceutical Sciences, 60 (2024),
https://doi.org/10.1590/s2175-97902024e23272 . .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Cvijić, Sandra
AU  - Đekić, Ljiljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5566
AB  - The pharmaceutical industry has faced significant changes in recent years, primarily influenced by regulatory standards, market competition, and the need to accelerate drug development. Model-informed drug development (MIDD) leverages quantitative computational models to facilitate decision-making processes. This approach sheds light on the complex interplay between the influence of a drug’s performance and the resulting clinical outcomes. This comprehensive review aims to explain the mechanisms that control the dissolution and/or release of drugs and their subsequent permeation through biological membranes. Furthermore, the importance of simulating these processes through a variety of in silico models is emphasized. Advanced compartmental absorption models provide an analytical framework to understand the kinetics of transit, dissolution, and absorption associated with orally administered drugs. In contrast, for topical and transdermal drug delivery systems, the prediction of drug permeation is predominantly based on quantitative structure–permeation relationships and molecular dynamics simulations. This review describes a variety of modeling strategies, ranging from mechanistic to empirical equations, and highlights the growing importance of state-of-the-art tools such as artificial intelligence, as well as advanced imaging and spectroscopic techniques.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration
VL  - 17
IS  - 2
DO  - 10.3390/ph17020177
ER  - 

@article{
author = "Đuriš, Jelena and Cvijić, Sandra and Đekić, Ljiljana",
year = "2024",
abstract = "The pharmaceutical industry has faced significant changes in recent years, primarily influenced by regulatory standards, market competition, and the need to accelerate drug development. Model-informed drug development (MIDD) leverages quantitative computational models to facilitate decision-making processes. This approach sheds light on the complex interplay between the influence of a drug’s performance and the resulting clinical outcomes. This comprehensive review aims to explain the mechanisms that control the dissolution and/or release of drugs and their subsequent permeation through biological membranes. Furthermore, the importance of simulating these processes through a variety of in silico models is emphasized. Advanced compartmental absorption models provide an analytical framework to understand the kinetics of transit, dissolution, and absorption associated with orally administered drugs. In contrast, for topical and transdermal drug delivery systems, the prediction of drug permeation is predominantly based on quantitative structure–permeation relationships and molecular dynamics simulations. This review describes a variety of modeling strategies, ranging from mechanistic to empirical equations, and highlights the growing importance of state-of-the-art tools such as artificial intelligence, as well as advanced imaging and spectroscopic techniques.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration",
volume = "17",
number = "2",
doi = "10.3390/ph17020177"
}

Đuriš, J., Cvijić, S.,& Đekić, L.. (2024). Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration. in Pharmaceuticals
MDPI., 17(2).
https://doi.org/10.3390/ph17020177

Đuriš J, Cvijić S, Đekić L. Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration. in Pharmaceuticals. 2024;17(2).
doi:10.3390/ph17020177 .

Đuriš, Jelena, Cvijić, Sandra, Đekić, Ljiljana, "Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration" in Pharmaceuticals, 17, no. 2 (2024),
https://doi.org/10.3390/ph17020177 . .

TY  - CONF
AU  - Đuriš, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5354
AB  - Farmaceutski oblici lekova prilagođeni specifičnim potrebama dece i starijih osoba su od
suštinskog značaja u obezbeđenju terapijske efikasnosti kod pacijenata iz ovih populacionih grupa.
Deca predstavljaju jedinstven izazov zbog svojih fizioloških karakteristika kao što su razlike u
metabolizmu, enzimatskoj aktivnosti i preferencijama ukusa, što zahteva razvoj inovativnih oblika
doziranja (1). Neki od njih su tablete za žvakanje, dispergovanje, sprinkle formulacije, mini-tablete i
oralno-disperzibilne forme. Razvijaju se i tečni farmaceutski oblici, sa fokusom na različite tehnike
maskiranja ukusa. Sa druge strane, izazovi koji se susreću u gerijatrijskoj populaciji pacijenata
uključuju polifarmaciju, kognitivne probleme i disfagiju, što iziskuje razvoj kobminovanih preparata
i farmaceutskih oblika koji su laki za primenu (uključujući i gutanje) uz odgovarajuću ambalažu koja
može da dodatno olakša doziranje i pruži jasne informacije (2). U slučaju obe populacije pacijenata
fokus je na razvoju bezbednih i efikasnih formulacija koje su prilagođene potrebama pacijenata i
karakteristikama patološkog stanja koje se leči (3). Sa tim u vezi, postoji značajan istraživački interes
za razvoj preparata za topikalnu i transdermalnu primenu preparata, formulacija sa modifikovanim
oslobađanjem, bukalnih i sublingvalnih formi. Savremeni trendovi uključuju i primenu raznih tehnika
3D štampanja, kao i različite inteligentne sisteme za isporuku lekova i/ili digitalne terapeutike. Jasno
je da prilagođavanje farmaceutskih oblika lekova može imati značajan uticaj na poboljšanje
terapijskih ishoda kod osetljivih populacija. Prikazane strategije u prilagođavanju oblika doziranja
imaju za cilj da omoguće bolje pridržavanje terapijskom režimu, smanjenje neželjenih efekata i
interakcija između lekova, i u krajnjem ishodu, poboljšanje kvaliteta života dece i starijih osoba.
AB  - Pharmaceutical dosage forms tailored to the specific needs of children and the elderly are
crucial in ensuring therapeutic efficacy for patients from these population groups. Children present
a unique challenge due to their physiological characteristics such as differences in metabolism,
enzymatic activity, and taste preferences, necessitating the development of innovative dosage forms
(1). Some of these are chewable and dispersible tablets, sprinkle formulations, mini-tablets, and
orally dispersible forms. Liquid pharmaceutical forms are also developed, with focus on various taste
masking techniques. Challenges encountered in the geriatric patient population include
polypharmacy, cognitive issues, and dysphagia, necessitating the development of combined products
and pharmaceutical forms that are easy to administer (including swallowing) with appropriate
packaging that can further facilitate dosing and provide clear information (2). In the case of both
patient populations, the focus is on the development of safe and effective formulations that are
tailored to the needs of the patients and the characteristics of the pathological condition being treated
(3). In this regard, there is significant research interest in the development of preparations for topical
and transdermal application, modified-release formulations, buccal, and sublingual forms. Modern
trends also include the application of various 3D printing techniques and diverse intelligent drug
delivery systems and/or digital therapeutics. It is evident that adapting pharmaceutical dosage forms
can have a significant impact on improving therapeutic outcomes in vulnerable populations.
Presented strategies in adapting dosage forms aim to enable better adherence to the therapeutic
regime, reduce adverse effects and interactions between drugs, and ultimately, improve the quality
of life of children and the elderly.
PB  - Savez farmaceutskih udruženja Srbije
C3  - Arhiv za farmaciju
T1  - Farmaceutski oblici lekova prilagođeni potrebama pedijatrijskih i gerijatrijskih pacijenata
T1  - Age matters: customizing dosage forms for pediatric and geriatric patients
VL  - 73
IS  - Suppl. 4
SP  - S13
EP  - S14
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5354
ER  - 

@conference{
author = "Đuriš, Jelena",
year = "2023",
abstract = "Farmaceutski oblici lekova prilagođeni specifičnim potrebama dece i starijih osoba su od
suštinskog značaja u obezbeđenju terapijske efikasnosti kod pacijenata iz ovih populacionih grupa.
Deca predstavljaju jedinstven izazov zbog svojih fizioloških karakteristika kao što su razlike u
metabolizmu, enzimatskoj aktivnosti i preferencijama ukusa, što zahteva razvoj inovativnih oblika
doziranja (1). Neki od njih su tablete za žvakanje, dispergovanje, sprinkle formulacije, mini-tablete i
oralno-disperzibilne forme. Razvijaju se i tečni farmaceutski oblici, sa fokusom na različite tehnike
maskiranja ukusa. Sa druge strane, izazovi koji se susreću u gerijatrijskoj populaciji pacijenata
uključuju polifarmaciju, kognitivne probleme i disfagiju, što iziskuje razvoj kobminovanih preparata
i farmaceutskih oblika koji su laki za primenu (uključujući i gutanje) uz odgovarajuću ambalažu koja
može da dodatno olakša doziranje i pruži jasne informacije (2). U slučaju obe populacije pacijenata
fokus je na razvoju bezbednih i efikasnih formulacija koje su prilagođene potrebama pacijenata i
karakteristikama patološkog stanja koje se leči (3). Sa tim u vezi, postoji značajan istraživački interes
za razvoj preparata za topikalnu i transdermalnu primenu preparata, formulacija sa modifikovanim
oslobađanjem, bukalnih i sublingvalnih formi. Savremeni trendovi uključuju i primenu raznih tehnika
3D štampanja, kao i različite inteligentne sisteme za isporuku lekova i/ili digitalne terapeutike. Jasno
je da prilagođavanje farmaceutskih oblika lekova može imati značajan uticaj na poboljšanje
terapijskih ishoda kod osetljivih populacija. Prikazane strategije u prilagođavanju oblika doziranja
imaju za cilj da omoguće bolje pridržavanje terapijskom režimu, smanjenje neželjenih efekata i
interakcija između lekova, i u krajnjem ishodu, poboljšanje kvaliteta života dece i starijih osoba., Pharmaceutical dosage forms tailored to the specific needs of children and the elderly are
crucial in ensuring therapeutic efficacy for patients from these population groups. Children present
a unique challenge due to their physiological characteristics such as differences in metabolism,
enzymatic activity, and taste preferences, necessitating the development of innovative dosage forms
(1). Some of these are chewable and dispersible tablets, sprinkle formulations, mini-tablets, and
orally dispersible forms. Liquid pharmaceutical forms are also developed, with focus on various taste
masking techniques. Challenges encountered in the geriatric patient population include
polypharmacy, cognitive issues, and dysphagia, necessitating the development of combined products
and pharmaceutical forms that are easy to administer (including swallowing) with appropriate
packaging that can further facilitate dosing and provide clear information (2). In the case of both
patient populations, the focus is on the development of safe and effective formulations that are
tailored to the needs of the patients and the characteristics of the pathological condition being treated
(3). In this regard, there is significant research interest in the development of preparations for topical
and transdermal application, modified-release formulations, buccal, and sublingual forms. Modern
trends also include the application of various 3D printing techniques and diverse intelligent drug
delivery systems and/or digital therapeutics. It is evident that adapting pharmaceutical dosage forms
can have a significant impact on improving therapeutic outcomes in vulnerable populations.
Presented strategies in adapting dosage forms aim to enable better adherence to the therapeutic
regime, reduce adverse effects and interactions between drugs, and ultimately, improve the quality
of life of children and the elderly.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Farmaceutski oblici lekova prilagođeni potrebama pedijatrijskih i gerijatrijskih pacijenata, Age matters: customizing dosage forms for pediatric and geriatric patients",
volume = "73",
number = "Suppl. 4",
pages = "S13-S14",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5354"
}

Đuriš, J.. (2023). Farmaceutski oblici lekova prilagođeni potrebama pedijatrijskih i gerijatrijskih pacijenata. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije., 73(Suppl. 4), S13-S14.
https://hdl.handle.net/21.15107/rcub_farfar_5354

Đuriš J. Farmaceutski oblici lekova prilagođeni potrebama pedijatrijskih i gerijatrijskih pacijenata. in Arhiv za farmaciju. 2023;73(Suppl. 4):S13-S14.
https://hdl.handle.net/21.15107/rcub_farfar_5354 .

Đuriš, Jelena, "Farmaceutski oblici lekova prilagođeni potrebama pedijatrijskih i gerijatrijskih pacijenata" in Arhiv za farmaciju, 73, no. Suppl. 4 (2023):S13-S14,
https://hdl.handle.net/21.15107/rcub_farfar_5354 .

TY  - CONF
AU  - Aleksić, Ivana
AU  - Ćirin-Varađan, Slobodanka
AU  - Glišić, Teodora
AU  - Petrović, Nađa
AU  - Đuriš, Jelena
AU  - Parojčić, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5067
AB  - Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression is particularly challenging when high API
loading is required. The use of co-processed excipients can
result in a robust directly compressible formulation, while
melt granulation has emerged as an environmentally
friendly co-processing method that can result in highly
functional co-processed excipients (Ćirin-Varađan et al,
2022).
The aim of the present study was to investigate the
suitability of lactose co-processed with glyceryl
palmitostearate for the preparation of a directly
compressible formulation of ibuprofen, a challenging high-
dose API. The influence of initial particle size of glyceryl
palmitostearate, ibuprofen content and compression
parameters on compaction behavior of tableting mixtures
was investigated.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations
VL  - 69
IS  - Suppl 1
SP  - 139
EP  - 140
DO  - 10.33320/maced.pharm.bull.2023.69.03.068
ER  - 

@conference{
author = "Aleksić, Ivana and Ćirin-Varađan, Slobodanka and Glišić, Teodora and Petrović, Nađa and Đuriš, Jelena and Parojčić, Jelena",
year = "2023",
abstract = "Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression is particularly challenging when high API
loading is required. The use of co-processed excipients can
result in a robust directly compressible formulation, while
melt granulation has emerged as an environmentally
friendly co-processing method that can result in highly
functional co-processed excipients (Ćirin-Varađan et al,
2022).
The aim of the present study was to investigate the
suitability of lactose co-processed with glyceryl
palmitostearate for the preparation of a directly
compressible formulation of ibuprofen, a challenging high-
dose API. The influence of initial particle size of glyceryl
palmitostearate, ibuprofen content and compression
parameters on compaction behavior of tableting mixtures
was investigated.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations",
volume = "69",
number = "Suppl 1",
pages = "139-140",
doi = "10.33320/maced.pharm.bull.2023.69.03.068"
}

Aleksić, I., Ćirin-Varađan, S., Glišić, T., Petrović, N., Đuriš, J.,& Parojčić, J.. (2023). From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 139-140.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.068

Aleksić I, Ćirin-Varađan S, Glišić T, Petrović N, Đuriš J, Parojčić J. From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):139-140.
doi:10.33320/maced.pharm.bull.2023.69.03.068 .

Aleksić, Ivana, Ćirin-Varađan, Slobodanka, Glišić, Teodora, Petrović, Nađa, Đuriš, Jelena, Parojčić, Jelena, "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):139-140,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.068 . .

TY  - JOUR
AU  - Glišić, Teodora
AU  - Đuriš, Jelena
AU  - Vasiljević, Ivana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4581
AB  - The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.
PB  - MDPI
T2  - Pharmaceutics
T1  - Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers
VL  - 15
IS  - 3
SP  - 741
EP  - 761
DO  - 10.3390/pharmaceutics15030741
ER  - 

@article{
author = "Glišić, Teodora and Đuriš, Jelena and Vasiljević, Ivana and Parojčić, Jelena and Aleksić, Ivana",
year = "2023",
abstract = "The processing of liquisolid systems (LSS), which are considered a promising approach
to improving the oral bioavailability of poorly soluble drugs, has proven challenging due to the
relatively high amount of liquid phase incorporated within them. The objective of this study was to
apply machine-learning tools to better understand the effects of formulation factors and/or tableting
process parameters on the flowability and compaction properties of LSS with silica-based mesoporous
excipients as carriers. In addition, the results of the flowability testing and dynamic compaction
analysis of liquisolid admixtures were used to build data sets and develop predictive multivariate
models. In the regression analysis, six different algorithms were used to model the relationship
between tensile strength (TS), the target variable, and eight other input variables. The AdaBoost
algorithm provided the best-fit model for predicting TS (coefficient of determination = 0.94), with
ejection stress (ES), compaction pressure, and carrier type being the parameters that influenced its
performance the most. The same algorithm was best for classification (precision = 0.90), depending on
the type of carrier used, with detachment stress, ES, and TS as variables affecting the performance of
the model. Furthermore, the formulations with Neusilin® US2 were able to maintain good flowability
and satisfactory values of TS despite having a higher liquid load compared to the other two carriers.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers",
volume = "15",
number = "3",
pages = "741-761",
doi = "10.3390/pharmaceutics15030741"
}

Glišić, T., Đuriš, J., Vasiljević, I., Parojčić, J.,& Aleksić, I.. (2023). Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics
MDPI., 15(3), 741-761.
https://doi.org/10.3390/pharmaceutics15030741

Glišić T, Đuriš J, Vasiljević I, Parojčić J, Aleksić I. Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers. in Pharmaceutics. 2023;15(3):741-761.
doi:10.3390/pharmaceutics15030741 .

Glišić, Teodora, Đuriš, Jelena, Vasiljević, Ivana, Parojčić, Jelena, Aleksić, Ivana, "Application of Machine-Learning Algorithms for Better Understanding the Properties of Liquisolid Systems Prepared with Three Mesoporous Silica Based Carriers" in Pharmaceutics, 15, no. 3 (2023):741-761,
https://doi.org/10.3390/pharmaceutics15030741 . .

TY  - JOUR
AU  - Kurćubić, Ivana
AU  - Đuriš, Jelena
AU  - Cvijić, Sandra
AU  - Crevar, Milkica
AU  - Ibrić, Svetlana
AU  - Miloradović, Zoran
AU  - Mihailović-Stanojević, Nevena
AU  - Karanović, Danijela
AU  - Ivanov, Milan
AU  - Jovović, Đurđica
AU  - Vajić, Una-Jovana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4932
AB  - In order to exploit the advantage of drug delivery through the buccal mucosa, mucoadhesive buccal films with propranolol hydrochloride based on polyethylene oxide, hydroxypropyl methylcellulose, and polyvinyl alcohol have been developed. The aim of this study was the development, pharmaceutical-technological (uniformity of mass and drug content, film thickness, potential interactions between polymers and propranolol hydrochloride, in vitro drug permeation and drug release, mechanical and mucoadhesive properties), and biopharmaceutical characterization of prepared mucoadhesive buccal films through conducting in vivo study in spontaneously hypertensive rats and in silico modeling of intraoral and gastrointestinal drug absorption. For in vivo study formulation F2 (hydroxypropylmethyl cellulose 0.5%, polyethylene oxide 3.5%, polyvinyl alcohol 1.5%, propylene glycol 3%, and propranolol hydrochloride 2%) was selected, which showed the highest values of tensile strength and percentage of elongation, as well as the highest value of the force of adhesion. Results of pharmacokinetic in rats and in silico modeling confirmed the superiority of the mucoadhesive buccal films over immediate-release tablets (in rats: AUC0→24h 66.13 ± 18.03 vs. 24.61 ± 5.52 μg⋅h/mL, AUC0→∞ 111.82 ± 39.04 vs. 47.85 ± 11.67 μg⋅h/mL; in silico: AUC0→24h 200.17 vs.74.58 ng⋅h/mL, AUC0→∞ 204.04 vs. 75.64 ng⋅h/mL). Hemodynamic measurements have shown that mucoadhesive buccal films, compared to immediate-release tablets, provide a more pronounced decrease primarily in heart rate (28-51%), but also in diastolic pressure (up to 33%), as well as a longer heart rate reduction that was maintained for up to 12th h. Therefore, mucoadhesive buccal films increased the degree of absorbed drug and thus contributed to better therapeutic outcomes compared to immediate-release tablets for peroral administration.
PB  - Elsevier
T2  - Journal of Drug Delivery Science and Technology
T1  - Integrated in vitro – in vivo – in silico studies in the pharmaceutical development of propranolol hydrochloride mucoadhesive buccal films
VL  - 86
DO  - 10.1016/j.jddst.2023.104715
ER  - 

@article{
author = "Kurćubić, Ivana and Đuriš, Jelena and Cvijić, Sandra and Crevar, Milkica and Ibrić, Svetlana and Miloradović, Zoran and Mihailović-Stanojević, Nevena and Karanović, Danijela and Ivanov, Milan and Jovović, Đurđica and Vajić, Una-Jovana",
year = "2023",
abstract = "In order to exploit the advantage of drug delivery through the buccal mucosa, mucoadhesive buccal films with propranolol hydrochloride based on polyethylene oxide, hydroxypropyl methylcellulose, and polyvinyl alcohol have been developed. The aim of this study was the development, pharmaceutical-technological (uniformity of mass and drug content, film thickness, potential interactions between polymers and propranolol hydrochloride, in vitro drug permeation and drug release, mechanical and mucoadhesive properties), and biopharmaceutical characterization of prepared mucoadhesive buccal films through conducting in vivo study in spontaneously hypertensive rats and in silico modeling of intraoral and gastrointestinal drug absorption. For in vivo study formulation F2 (hydroxypropylmethyl cellulose 0.5%, polyethylene oxide 3.5%, polyvinyl alcohol 1.5%, propylene glycol 3%, and propranolol hydrochloride 2%) was selected, which showed the highest values of tensile strength and percentage of elongation, as well as the highest value of the force of adhesion. Results of pharmacokinetic in rats and in silico modeling confirmed the superiority of the mucoadhesive buccal films over immediate-release tablets (in rats: AUC0→24h 66.13 ± 18.03 vs. 24.61 ± 5.52 μg⋅h/mL, AUC0→∞ 111.82 ± 39.04 vs. 47.85 ± 11.67 μg⋅h/mL; in silico: AUC0→24h 200.17 vs.74.58 ng⋅h/mL, AUC0→∞ 204.04 vs. 75.64 ng⋅h/mL). Hemodynamic measurements have shown that mucoadhesive buccal films, compared to immediate-release tablets, provide a more pronounced decrease primarily in heart rate (28-51%), but also in diastolic pressure (up to 33%), as well as a longer heart rate reduction that was maintained for up to 12th h. Therefore, mucoadhesive buccal films increased the degree of absorbed drug and thus contributed to better therapeutic outcomes compared to immediate-release tablets for peroral administration.",
publisher = "Elsevier",
journal = "Journal of Drug Delivery Science and Technology",
title = "Integrated in vitro – in vivo – in silico studies in the pharmaceutical development of propranolol hydrochloride mucoadhesive buccal films",
volume = "86",
doi = "10.1016/j.jddst.2023.104715"
}

Kurćubić, I., Đuriš, J., Cvijić, S., Crevar, M., Ibrić, S., Miloradović, Z., Mihailović-Stanojević, N., Karanović, D., Ivanov, M., Jovović, Đ.,& Vajić, U.. (2023). Integrated in vitro – in vivo – in silico studies in the pharmaceutical development of propranolol hydrochloride mucoadhesive buccal films. in Journal of Drug Delivery Science and Technology
Elsevier., 86.
https://doi.org/10.1016/j.jddst.2023.104715

Kurćubić I, Đuriš J, Cvijić S, Crevar M, Ibrić S, Miloradović Z, Mihailović-Stanojević N, Karanović D, Ivanov M, Jovović Đ, Vajić U. Integrated in vitro – in vivo – in silico studies in the pharmaceutical development of propranolol hydrochloride mucoadhesive buccal films. in Journal of Drug Delivery Science and Technology. 2023;86.
doi:10.1016/j.jddst.2023.104715 .

Kurćubić, Ivana, Đuriš, Jelena, Cvijić, Sandra, Crevar, Milkica, Ibrić, Svetlana, Miloradović, Zoran, Mihailović-Stanojević, Nevena, Karanović, Danijela, Ivanov, Milan, Jovović, Đurđica, Vajić, Una-Jovana, "Integrated in vitro – in vivo – in silico studies in the pharmaceutical development of propranolol hydrochloride mucoadhesive buccal films" in Journal of Drug Delivery Science and Technology, 86 (2023),
https://doi.org/10.1016/j.jddst.2023.104715 . .

TY  - JOUR
AU  - Krstevska, Aleksandra
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4420
AB  - In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to its application in various research topics and model validation was conducted by text mining tools. Orange 3.32.0, an open-source data mining program was used for text mining. PubMed was used for data retrieval, and the collected articles were analyzed by several widgets. A total of 2699 articles related to PBPK modeling met the predefined criteria. The number of publications per year has been rising steadily. Regarding the application areas, the results revealed that 26% of the publications described the use of PBPK modeling in early drug development, risk assessment and toxicity assessment, followed by absorption/formulation modeling (25%), prediction of drug-disease interactions (20%), drug-drug interactions (DDIs) (17%) and pediatric drug development (12%). Furthermore, the analysis showed that only 12% of the publications mentioned model validation, of which 51% referred to literature-based validation and 26% to experimentally validated models. The obtained results present a valuable review of the state-of-the-art regarding PBPK modeling applications in drug discovery and development and related fields.
PB  - MDPI
T2  - Pharmaceutics
T1  - In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools
VL  - 15
IS  - 1
DO  - 10.3390/pharmaceutics15010107
ER  - 

@article{
author = "Krstevska, Aleksandra and Đuriš, Jelena and Ibrić, Svetlana and Cvijić, Sandra",
year = "2023",
abstract = "In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to its application in various research topics and model validation was conducted by text mining tools. Orange 3.32.0, an open-source data mining program was used for text mining. PubMed was used for data retrieval, and the collected articles were analyzed by several widgets. A total of 2699 articles related to PBPK modeling met the predefined criteria. The number of publications per year has been rising steadily. Regarding the application areas, the results revealed that 26% of the publications described the use of PBPK modeling in early drug development, risk assessment and toxicity assessment, followed by absorption/formulation modeling (25%), prediction of drug-disease interactions (20%), drug-drug interactions (DDIs) (17%) and pediatric drug development (12%). Furthermore, the analysis showed that only 12% of the publications mentioned model validation, of which 51% referred to literature-based validation and 26% to experimentally validated models. The obtained results present a valuable review of the state-of-the-art regarding PBPK modeling applications in drug discovery and development and related fields.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools",
volume = "15",
number = "1",
doi = "10.3390/pharmaceutics15010107"
}

Krstevska, A., Đuriš, J., Ibrić, S.,& Cvijić, S.. (2023). In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools. in Pharmaceutics
MDPI., 15(1).
https://doi.org/10.3390/pharmaceutics15010107

Krstevska A, Đuriš J, Ibrić S, Cvijić S. In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools. in Pharmaceutics. 2023;15(1).
doi:10.3390/pharmaceutics15010107 .

Krstevska, Aleksandra, Đuriš, Jelena, Ibrić, Svetlana, Cvijić, Sandra, "In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools" in Pharmaceutics, 15, no. 1 (2023),
https://doi.org/10.3390/pharmaceutics15010107 . .

TY  - CONF
AU  - Đuriš, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5010
AB  - Patient acceptance and usability play a crucial role in achieving successful therapeutic outcomes. Consequently, there is an imperative to incorporate patient-focused formulation design into the pharmaceutical development process, particularly for more vulnerable patient populations such as paediatric and geriatric. This approach aligns with the scientific quality by design (QbD) principle, where products' critical quality attributes (CQAs), as well as critical attributes of the starting materials (CMAs) and critical process parameter (CPPs) are identified and tailored to accommodate patient-related attributes. 
A number of marketed products have failed to reach their full therapeutic potential due to insufficient recognition of patients' needs and the characteristics of the treated disease or condition. As a result, science-based patient-focused formulation development is now supported through regulatory programs and guidelines. Advanced data analysis and computational tools are also leveraged to support safety and effectiveness of new drugs. Regulatory agencies frequently convene expert advisory committees comprising scientists, clinicians, and patient representatives to review and evaluate new drug applications. Various approaches to patient-focused formulation development encompass the selection of specific dosage forms and/or administration routes (e.g. orodispersible and chewable tablets, transdermal patches), modified release formulations (delivering drugs over daily to yearly time frames depending on the dosage form), combination products (mostly marketed as fixed-dose combinations of cardiovascular medicines), personalized medicines (customized based on patients' genetic and/or metabolic characteristics), etc. The identification of potential polypharmacy requirements and specific changes in (patho)physiology, metabolism, and excretion, as well as side effects or changes in behavioral traits arising from the disease's progress, should remain some of key drivers for product design. For special patient groups like children, considerations of palatability (including taste masking), dose adjustment, and age-appropriate dosage forms are essential. 
Challenges associated with such an approach include heterogeneity of patients, including small sub-populations, and complex process that requires high-risk decision-making during the formulation development. Therefore, fostering scientific evidence and guidance from the early stages of new formulation development, while considering all potential CQAs that might contribute to products' acceptability and usability, is crucial.
PB  - International Association of Physical Chemists
C3  - 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6
T1  - Bridging science & regulation: quality by design in patient- focused formulation development
SP  - 35
EP  - 35
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5010
ER  - 

@conference{
author = "Đuriš, Jelena",
year = "2023",
abstract = "Patient acceptance and usability play a crucial role in achieving successful therapeutic outcomes. Consequently, there is an imperative to incorporate patient-focused formulation design into the pharmaceutical development process, particularly for more vulnerable patient populations such as paediatric and geriatric. This approach aligns with the scientific quality by design (QbD) principle, where products' critical quality attributes (CQAs), as well as critical attributes of the starting materials (CMAs) and critical process parameter (CPPs) are identified and tailored to accommodate patient-related attributes. 
A number of marketed products have failed to reach their full therapeutic potential due to insufficient recognition of patients' needs and the characteristics of the treated disease or condition. As a result, science-based patient-focused formulation development is now supported through regulatory programs and guidelines. Advanced data analysis and computational tools are also leveraged to support safety and effectiveness of new drugs. Regulatory agencies frequently convene expert advisory committees comprising scientists, clinicians, and patient representatives to review and evaluate new drug applications. Various approaches to patient-focused formulation development encompass the selection of specific dosage forms and/or administration routes (e.g. orodispersible and chewable tablets, transdermal patches), modified release formulations (delivering drugs over daily to yearly time frames depending on the dosage form), combination products (mostly marketed as fixed-dose combinations of cardiovascular medicines), personalized medicines (customized based on patients' genetic and/or metabolic characteristics), etc. The identification of potential polypharmacy requirements and specific changes in (patho)physiology, metabolism, and excretion, as well as side effects or changes in behavioral traits arising from the disease's progress, should remain some of key drivers for product design. For special patient groups like children, considerations of palatability (including taste masking), dose adjustment, and age-appropriate dosage forms are essential. 
Challenges associated with such an approach include heterogeneity of patients, including small sub-populations, and complex process that requires high-risk decision-making during the formulation development. Therefore, fostering scientific evidence and guidance from the early stages of new formulation development, while considering all potential CQAs that might contribute to products' acceptability and usability, is crucial.",
publisher = "International Association of Physical Chemists",
journal = "10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6",
title = "Bridging science & regulation: quality by design in patient- focused formulation development",
pages = "35-35",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5010"
}

Đuriš, J.. (2023). Bridging science & regulation: quality by design in patient- focused formulation development. in 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6
International Association of Physical Chemists., 35-35.
https://hdl.handle.net/21.15107/rcub_farfar_5010

Đuriš J. Bridging science & regulation: quality by design in patient- focused formulation development. in 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6. 2023;:35-35.
https://hdl.handle.net/21.15107/rcub_farfar_5010 .

Đuriš, Jelena, "Bridging science & regulation: quality by design in patient- focused formulation development" in 10th IAPC Meeting Tenth World Conference on Physico-Chemical Methods in Drug Discovery & Sixth World Conference on ADMET and DMPK Belgrade, Serbia, September 4-6 (2023):35-35,
https://hdl.handle.net/21.15107/rcub_farfar_5010 .

TY  - CONF
AU  - Krstevska, Aleksandra
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Cvijić, Sandra
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5068
AB  - Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability to mechanistically explain how drug properties,
product quality attributes and physiological factors
influence the in vivo drug performance. To better specify
the application field of these models and highlight the link
between in vitro dissolution and drug’s in vivo behavior, a
novel term, physiologically based biopharmaceutics
modeling (PBBM), was recently introduced.
The versatility of application of these models is
perceived through the growth in the number of scientific
publications that include the use of PBPK/PBBM
(Krstevska et al, 2022). In the present study, the use of
PBPK/PBBM across the publications from the past decade
was analyzed, with the focus on the application of these
models in pharmaceutical/formulation development.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development
VL  - 69
IS  - Suppl 1
SP  - 145
EP  - 146
DO  - 10.33320/maced.pharm.bull.2023.69.03.071
ER  - 

@conference{
author = "Krstevska, Aleksandra and Đuriš, Jelena and Ibrić, Svetlana and Cvijić, Sandra",
year = "2023",
abstract = "Physiologically based pharmacokinetic (PBPK)
modeling is an evolving tool that has a profound impact on
drug discovery and formulation development processes. A
major advantage of PBPK models is that they have the
ability to mechanistically explain how drug properties,
product quality attributes and physiological factors
influence the in vivo drug performance. To better specify
the application field of these models and highlight the link
between in vitro dissolution and drug’s in vivo behavior, a
novel term, physiologically based biopharmaceutics
modeling (PBBM), was recently introduced.
The versatility of application of these models is
perceived through the growth in the number of scientific
publications that include the use of PBPK/PBBM
(Krstevska et al, 2022). In the present study, the use of
PBPK/PBBM across the publications from the past decade
was analyzed, with the focus on the application of these
models in pharmaceutical/formulation development.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development",
volume = "69",
number = "Suppl 1",
pages = "145-146",
doi = "10.33320/maced.pharm.bull.2023.69.03.071"
}

Krstevska, A., Đuriš, J., Ibrić, S.,& Cvijić, S.. (2023). A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 145-146.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.071

Krstevska A, Đuriš J, Ibrić S, Cvijić S. A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):145-146.
doi:10.33320/maced.pharm.bull.2023.69.03.071 .

Krstevska, Aleksandra, Đuriš, Jelena, Ibrić, Svetlana, Cvijić, Sandra, "A text mining study on the utility of physiologically based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) in formulation development" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):145-146,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.071 . .

TY  - CHAP
AU  - Vidović, Bojana
AU  - Marčetić, Mirjana
AU  - Đuriš, Jelena
AU  - Milinčić, Danijel
AU  - Kostić, Aleksandar
AU  - Pešić, Mirjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5270
AB  - Apart from traditional medicine use, the fruit of Lycium barbarum L., known as red goji berry or wolfberry, is recognized and consumed as a functional food. Beyond nutritional properties, goji berry exerts many biological activities and health-promoting effects due to wide-range phytochemicals. Rising global popularity and high demand have spread the production of goji berries from traditional Asian regions into various parts of the world. In addition, other native species, as Lycium ruthenicum Murr., or black goji berry, also have been started to generate attention by the scientific community as a valuable source of nutritional and functional components. This chapter reviews data on nutritional value and bioactive compounds of red and black goji berries from different regions, highlighting the influence of many pre-harvest and post-harvest factors that affect their chemical compositions, sensory quality, and bioactivities.
PB  - Elsevier
T2  - Sustainable Food Science - A Comprehensive Approach
T1  - Goji Berries: Valuable Sources of Nutrients and Bioactive Compounds
VL  - 1-4
SP  - V3-247
EP  - V3-262
DO  - 10.1016/B978-0-12-823960-5.00031-7
ER  - 

@inbook{
author = "Vidović, Bojana and Marčetić, Mirjana and Đuriš, Jelena and Milinčić, Danijel and Kostić, Aleksandar and Pešić, Mirjana",
year = "2023",
abstract = "Apart from traditional medicine use, the fruit of Lycium barbarum L., known as red goji berry or wolfberry, is recognized and consumed as a functional food. Beyond nutritional properties, goji berry exerts many biological activities and health-promoting effects due to wide-range phytochemicals. Rising global popularity and high demand have spread the production of goji berries from traditional Asian regions into various parts of the world. In addition, other native species, as Lycium ruthenicum Murr., or black goji berry, also have been started to generate attention by the scientific community as a valuable source of nutritional and functional components. This chapter reviews data on nutritional value and bioactive compounds of red and black goji berries from different regions, highlighting the influence of many pre-harvest and post-harvest factors that affect their chemical compositions, sensory quality, and bioactivities.",
publisher = "Elsevier",
journal = "Sustainable Food Science - A Comprehensive Approach",
booktitle = "Goji Berries: Valuable Sources of Nutrients and Bioactive Compounds",
volume = "1-4",
pages = "V3-247-V3-262",
doi = "10.1016/B978-0-12-823960-5.00031-7"
}

Vidović, B., Marčetić, M., Đuriš, J., Milinčić, D., Kostić, A.,& Pešić, M.. (2023). Goji Berries: Valuable Sources of Nutrients and Bioactive Compounds. in Sustainable Food Science - A Comprehensive Approach
Elsevier., 1-4, V3-247-V3-262.
https://doi.org/10.1016/B978-0-12-823960-5.00031-7

Vidović B, Marčetić M, Đuriš J, Milinčić D, Kostić A, Pešić M. Goji Berries: Valuable Sources of Nutrients and Bioactive Compounds. in Sustainable Food Science - A Comprehensive Approach. 2023;1-4:V3-247-V3-262.
doi:10.1016/B978-0-12-823960-5.00031-7 .

Vidović, Bojana, Marčetić, Mirjana, Đuriš, Jelena, Milinčić, Danijel, Kostić, Aleksandar, Pešić, Mirjana, "Goji Berries: Valuable Sources of Nutrients and Bioactive Compounds" in Sustainable Food Science - A Comprehensive Approach, 1-4 (2023):V3-247-V3-262,
https://doi.org/10.1016/B978-0-12-823960-5.00031-7 . .

TY  - CONF
AU  - Kurćubić, Ivana
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5065
AB  - Multivariate analysis methods are a set of statistical
techniques that allow multiple variables to be tested
simultaneously. This makes them ideal for studying
relationships in large complex datasets. Pharmaceutical
products and drug manufacturing processes are complex
systems by nature and can therefore, be described using
multifactorial relationships. One of the commonly used
methods of multivariate analysis is principal components
analysis (PCA), which in short, transforms a large set of
variables into a smaller set of new variables, which are
designated as principal components (PCs). Principal
component represents a linear combination of the original
variables (Ferreira et Tobyn, 2015; Esbensen et Geladi,
2009). This study aimed to investigate the variability and
the possibility of differentiation of the formulated buccal
tablet formulations using PCA.
PB  - Macedonian Pharmaceutical Association
PB  - Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy
C3  - Macedonian Pharmaceutical Bulletin
T1  - Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis
VL  - 69
IS  - Suppl 1
SP  - 129
EP  - 130
DO  - 10.33320/maced.pharm.bull.2023.69.03.063
ER  - 

@conference{
author = "Kurćubić, Ivana and Ibrić, Svetlana and Đuriš, Jelena",
year = "2023",
abstract = "Multivariate analysis methods are a set of statistical
techniques that allow multiple variables to be tested
simultaneously. This makes them ideal for studying
relationships in large complex datasets. Pharmaceutical
products and drug manufacturing processes are complex
systems by nature and can therefore, be described using
multifactorial relationships. One of the commonly used
methods of multivariate analysis is principal components
analysis (PCA), which in short, transforms a large set of
variables into a smaller set of new variables, which are
designated as principal components (PCs). Principal
component represents a linear combination of the original
variables (Ferreira et Tobyn, 2015; Esbensen et Geladi,
2009). This study aimed to investigate the variability and
the possibility of differentiation of the formulated buccal
tablet formulations using PCA.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis",
volume = "69",
number = "Suppl 1",
pages = "129-130",
doi = "10.33320/maced.pharm.bull.2023.69.03.063"
}

Kurćubić, I., Ibrić, S.,& Đuriš, J.. (2023). Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis. in Macedonian Pharmaceutical Bulletin
Macedonian Pharmaceutical Association., 69(Suppl 1), 129-130.
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.063

Kurćubić I, Ibrić S, Đuriš J. Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis. in Macedonian Pharmaceutical Bulletin. 2023;69(Suppl 1):129-130.
doi:10.33320/maced.pharm.bull.2023.69.03.063 .

Kurćubić, Ivana, Ibrić, Svetlana, Đuriš, Jelena, "Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis" in Macedonian Pharmaceutical Bulletin, 69, no. Suppl 1 (2023):129-130,
https://doi.org/10.33320/maced.pharm.bull.2023.69.03.063 . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milinčić, Danijel
AU  - Marčetić, Mirjana
AU  - Đuriš, Jelena
AU  - Ilić, Tijana
AU  - Kostić, Aleksandar
AU  - Pešić, Mirjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4053
AB  - Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.
PB  - MDPI
T2  - Antioxidants
T1  - Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review
VL  - 11
IS  - 2
DO  - 10.3390/antiox11020248
ER  - 

@article{
author = "Vidović, Bojana and Milinčić, Danijel and Marčetić, Mirjana and Đuriš, Jelena and Ilić, Tijana and Kostić, Aleksandar and Pešić, Mirjana",
year = "2022",
abstract = "Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due to wide-range bioactive compounds with health-promoting properties. In addition, they are gaining increased research attention as a source of functional ingredients with potential industrial applications. This review focuses on the antioxidant properties of goji berries, scientific evidence on their health effects based on human interventional studies, safety concerns, goji berry processing technologies, and applications of goji berry-based ingredients in developing functional food products.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review",
volume = "11",
number = "2",
doi = "10.3390/antiox11020248"
}

Vidović, B., Milinčić, D., Marčetić, M., Đuriš, J., Ilić, T., Kostić, A.,& Pešić, M.. (2022). Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review. in Antioxidants
MDPI., 11(2).
https://doi.org/10.3390/antiox11020248

Vidović B, Milinčić D, Marčetić M, Đuriš J, Ilić T, Kostić A, Pešić M. Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review. in Antioxidants. 2022;11(2).
doi:10.3390/antiox11020248 .

Vidović, Bojana, Milinčić, Danijel, Marčetić, Mirjana, Đuriš, Jelena, Ilić, Tijana, Kostić, Aleksandar, Pešić, Mirjana, "Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review" in Antioxidants, 11, no. 2 (2022),
https://doi.org/10.3390/antiox11020248 . .

TY  - CONF
AU  - Aleksić, Ivana
AU  - Ćirin-Varađan, Slobodanka
AU  - Glišić, Teodora
AU  - Đuriš, Mihal
AU  - Đuriš, Jelena
AU  - Parojčić, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4735
AB  - 1. INTRODUCTION
Co-processing has emerged as a suitable
approach to meet the increasing demands for
excipients with improved tableting
performance. Apart from the most commonly
used energy-consuming co-processing methods
(e.g. spray-drying and wet granulation), melt
granulation as a solvent-free and more
environmentally friendly technique has recently
gained more attention [1].
The aim of the present study was to investigate
the influence of meltable binder particle size
and compaction parameters on dilution capacity
and compaction behaviour of lactose-based coprocessed
excipients.
2. MATERIALS AND METHODS
2.1. Materials
Paracetamol (Acros Organics, Belgium) was
used as the model drug. Lactose monohydrate
(Carlo Erba Reagents, Italy) was used as filler
and glyceryl palmitostearate (Precirol® ATO 5
Gattefossé S.A.S, France) as meltable binder.
2.2. Preparation of co-processed excipients
Co-processed excipients were prepared by in
situ melt granulation in Mycrolab fluid bed
processor (OYSTAR Hüttlin, Germany).
Precirol® particles (15%) from the 125–180 μm
(≈ 150 μm) or 600–710 μm sieve fraction (≈ 655
μm) were used for granulation of lactose (85%).
The inlet air flow rate was 30 m3/h, and product
temperature during agglomeration was 65 °C.
2.3. Particle size and shape analysis
Granule size distribution was evaluated by sieve
analysis, and median particle diameter (d50) was
calculated by linear interpolation of the
cumulative percentage frequency curve.
Granule shape was examined by 2D scanned
image (4800 dpi resolution) analysis using
ImageJ software. The aspect ratio (AR) and
circularity (C) were calculated for granule shape
evaluation.
2.3. Determination of the Carr index
The bulk and tapped (1250 taps) densities of coprocessed
excipients and their mixtures with 30,
40 or 50% paracetamol were determined using
tap density tester STAV 2003 (J. Engelsmann
AG, Germany), and Carr index was calculated.
2.4. Dynamic compaction analysis
Co-processed excipients and their mixtures with
paracetamol were compressed on a single punch
instrumented tablet press (GTP D series,
Gamlen Tableting Ltd, UK). Compacts (100
mg) were compressed under compression load
of 200 kg (≈ 70 MPa) or 500 kg (≈ 173MPa),
and compression speed of 60 or 120 mm/min. 6
mm flat faced punches were used. The obtained
force-displacement curves were used to
calculate: net work of compression (NW),
detachment stress (DS), ejection stress (ES).
Tablet crushing force was determined using
tablet hardness tester Erweka TBH 125D
(Erweka GmbH, Germany), and the values
obtained were used to calculate tensile strength
(TS). Elastic recovery (24 h after compression)
was calculated, as well.
2.4. Experimental Design
In order to investigate the influence of binder
particle size, paracetamol content and
compression speed on the abovementioned
compaction properties, compacts were
prepared, at compression load of 500 kg,
according to 23 full factorial design.
3. RESULTS AND DISCUSSION
3.1. Particle size and shape
Larger initial binder particle size led to
formation of larger and more spherical granules
(Table 1).
147
Table 1. The size and shape of the co-processed
excipients’ particles.
Binder PS (μm) d50 AR C
150 564.9 1.33 0.81
655 846.2 1.14 0.86
3.2. Flowability
The Carr index values obtained indicated
considerably better flowability of the coprocessed
excipient prepared by using larger
binder particles (P655) in comparison with the
excipient prepared with smaller binder particles
(P150). This might be ascribed to more
spherical and larger particles of P655. However,
the addition of paracetamol led to an increase in
Carr index values and less pronounced
differences between two excipients (Fig. 1).
Figure 1. The influence of paracetamol loading
on flowability of co-processed excipients.
3.3. Compaction behaviour
The results obtained revealed better mechanical
properties of P150 in comparison with P655
compacts, irrespective of the compression
pressure applied. The addition of paracetamol,
as the model API with poor compaction
properties, led to decrease in tensile strength of
the compacts prepared with both excipients, and
paracetamol content showed statistically
significant influence on TS (p < 0.0001).
Acceptable tensile strength (> 1 MPa) could be
achieved for compacts with 30% paracetamol
compressed at higher compression pressure (≈
173 MPa).
Paracetamol content, compression speed and
interaction between binder particle size and
paracetamol content were found to significantly
affect NW. The influence of binder particle size
was more pronounced at higher paracetamol
content, with lower NW observed in the case of
P655. Higher compression speed led to higher
NW.
Relatively low values of detachment and
ejection stress (< 3.5 MPa) indicate good
antiadhesive and lubricating properties of the
investigated excipients. Lower values of both
parameters were observed in the case of P655
which could be related to different
agglomeration mechanisms involved. Besides
binder particle size, compression speed and
paracetamol content were found to significantly
influence these properties.
Elastic recovery values of the investigated
samples ranged between 12 and 28%. In the
case of both excipients, higher elastic recovery
values were obtained at higher compression
pressure. ER values of the compacts prepared at
higher compression pressure were significantly
affected by compression speed and interactions
of the investigated variables.
4. CONCLUSION
The results obtained show that meltable binder
particle size affects granule size and shape, and
consequently may influence flowability and
compaction behaviour of the co-processed
excipients. Interactions between binder particle
size and compaction variables were also found
to affect compaction properties of the
investigated excipients.
PB  - Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo
C3  - 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
T1  - Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation
SP  - 146
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4735
ER  - 

@conference{
author = "Aleksić, Ivana and Ćirin-Varađan, Slobodanka and Glišić, Teodora and Đuriš, Mihal and Đuriš, Jelena and Parojčić, Jelena",
year = "2022",
abstract = "1. INTRODUCTION
Co-processing has emerged as a suitable
approach to meet the increasing demands for
excipients with improved tableting
performance. Apart from the most commonly
used energy-consuming co-processing methods
(e.g. spray-drying and wet granulation), melt
granulation as a solvent-free and more
environmentally friendly technique has recently
gained more attention [1].
The aim of the present study was to investigate
the influence of meltable binder particle size
and compaction parameters on dilution capacity
and compaction behaviour of lactose-based coprocessed
excipients.
2. MATERIALS AND METHODS
2.1. Materials
Paracetamol (Acros Organics, Belgium) was
used as the model drug. Lactose monohydrate
(Carlo Erba Reagents, Italy) was used as filler
and glyceryl palmitostearate (Precirol® ATO 5
Gattefossé S.A.S, France) as meltable binder.
2.2. Preparation of co-processed excipients
Co-processed excipients were prepared by in
situ melt granulation in Mycrolab fluid bed
processor (OYSTAR Hüttlin, Germany).
Precirol® particles (15%) from the 125–180 μm
(≈ 150 μm) or 600–710 μm sieve fraction (≈ 655
μm) were used for granulation of lactose (85%).
The inlet air flow rate was 30 m3/h, and product
temperature during agglomeration was 65 °C.
2.3. Particle size and shape analysis
Granule size distribution was evaluated by sieve
analysis, and median particle diameter (d50) was
calculated by linear interpolation of the
cumulative percentage frequency curve.
Granule shape was examined by 2D scanned
image (4800 dpi resolution) analysis using
ImageJ software. The aspect ratio (AR) and
circularity (C) were calculated for granule shape
evaluation.
2.3. Determination of the Carr index
The bulk and tapped (1250 taps) densities of coprocessed
excipients and their mixtures with 30,
40 or 50% paracetamol were determined using
tap density tester STAV 2003 (J. Engelsmann
AG, Germany), and Carr index was calculated.
2.4. Dynamic compaction analysis
Co-processed excipients and their mixtures with
paracetamol were compressed on a single punch
instrumented tablet press (GTP D series,
Gamlen Tableting Ltd, UK). Compacts (100
mg) were compressed under compression load
of 200 kg (≈ 70 MPa) or 500 kg (≈ 173MPa),
and compression speed of 60 or 120 mm/min. 6
mm flat faced punches were used. The obtained
force-displacement curves were used to
calculate: net work of compression (NW),
detachment stress (DS), ejection stress (ES).
Tablet crushing force was determined using
tablet hardness tester Erweka TBH 125D
(Erweka GmbH, Germany), and the values
obtained were used to calculate tensile strength
(TS). Elastic recovery (24 h after compression)
was calculated, as well.
2.4. Experimental Design
In order to investigate the influence of binder
particle size, paracetamol content and
compression speed on the abovementioned
compaction properties, compacts were
prepared, at compression load of 500 kg,
according to 23 full factorial design.
3. RESULTS AND DISCUSSION
3.1. Particle size and shape
Larger initial binder particle size led to
formation of larger and more spherical granules
(Table 1).
147
Table 1. The size and shape of the co-processed
excipients’ particles.
Binder PS (μm) d50 AR C
150 564.9 1.33 0.81
655 846.2 1.14 0.86
3.2. Flowability
The Carr index values obtained indicated
considerably better flowability of the coprocessed
excipient prepared by using larger
binder particles (P655) in comparison with the
excipient prepared with smaller binder particles
(P150). This might be ascribed to more
spherical and larger particles of P655. However,
the addition of paracetamol led to an increase in
Carr index values and less pronounced
differences between two excipients (Fig. 1).
Figure 1. The influence of paracetamol loading
on flowability of co-processed excipients.
3.3. Compaction behaviour
The results obtained revealed better mechanical
properties of P150 in comparison with P655
compacts, irrespective of the compression
pressure applied. The addition of paracetamol,
as the model API with poor compaction
properties, led to decrease in tensile strength of
the compacts prepared with both excipients, and
paracetamol content showed statistically
significant influence on TS (p < 0.0001).
Acceptable tensile strength (> 1 MPa) could be
achieved for compacts with 30% paracetamol
compressed at higher compression pressure (≈
173 MPa).
Paracetamol content, compression speed and
interaction between binder particle size and
paracetamol content were found to significantly
affect NW. The influence of binder particle size
was more pronounced at higher paracetamol
content, with lower NW observed in the case of
P655. Higher compression speed led to higher
NW.
Relatively low values of detachment and
ejection stress (< 3.5 MPa) indicate good
antiadhesive and lubricating properties of the
investigated excipients. Lower values of both
parameters were observed in the case of P655
which could be related to different
agglomeration mechanisms involved. Besides
binder particle size, compression speed and
paracetamol content were found to significantly
influence these properties.
Elastic recovery values of the investigated
samples ranged between 12 and 28%. In the
case of both excipients, higher elastic recovery
values were obtained at higher compression
pressure. ER values of the compacts prepared at
higher compression pressure were significantly
affected by compression speed and interactions
of the investigated variables.
4. CONCLUSION
The results obtained show that meltable binder
particle size affects granule size and shape, and
consequently may influence flowability and
compaction behaviour of the co-processed
excipients. Interactions between binder particle
size and compaction variables were also found
to affect compaction properties of the
investigated excipients.",
publisher = "Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo",
journal = "9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts",
title = "Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation",
pages = "146-147",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4735"
}

Aleksić, I., Ćirin-Varađan, S., Glišić, T., Đuriš, M., Đuriš, J.,& Parojčić, J.. (2022). Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts
Slovensko farmacevtsko društvo in Univerza v Ljubljani, Fakulteta za farmacijo., 146-147.
https://hdl.handle.net/21.15107/rcub_farfar_4735

Aleksić I, Ćirin-Varađan S, Glišić T, Đuriš M, Đuriš J, Parojčić J. Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation. in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts. 2022;:146-147.
https://hdl.handle.net/21.15107/rcub_farfar_4735 .

Aleksić, Ivana, Ćirin-Varađan, Slobodanka, Glišić, Teodora, Đuriš, Mihal, Đuriš, Jelena, Parojčić, Jelena, "Evaluation of dilution capacity and compaction behaviour of the excipients co-processed by in situ fluidized bed melt granulation" in 9th BBBB International Conference on Pharmaceutical Sciences Pharma Sciences of Tomorrow: Book of Abstracts (2022):146-147,
https://hdl.handle.net/21.15107/rcub_farfar_4735 .

TY  - JOUR
AU  - Ćirin-Varađan, Slobodanka
AU  - Đuriš, Jelena
AU  - Mirković, Miljana
AU  - Ivanović, Marija
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4001
AB  - The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of coprocessed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as a promising co-processing technique. The aim of the present study was to prepare lipid-based co-processed excipients by in situ fluidized bed melt granulation and to investigated their suitability for direct compression process. Lactose monohydrate was co-processed with glyceryl dibehenate (Compritol® 888 ATO) or glyceryl palmitostearate (Precirol® ATO 5), as lipophilic meltable binders. Besides the flowability testing, dynamic compaction analysis was applied for thorough investigation into the tableting properties of developed coprocessed excipients. Solid state characterization, performed by means of XRPD and DRIFT, confirmed the absence of chemical changes of the single components of co-processed excipients. Co-processed excipients showed improved flowability in comparison with single ingredients and corresponding physical mixtures. Novel co-processed excipients were found to have better tabletability profiles than physical mixtures of the ingredients, and were able to retain acceptable tensile strength values at high content of paracetamol in tableting mixture. Tablets with high tensile strength could be obtained with less work of compression needed in comparison with the commercial lactose-based excipients. Furthermore, novel lipid-based co-processed excipients were found to be highly superior regarding the antiadhesive and lubricating properties, with no additional lubricants required.
PB  - Elsevier B.V.
T2  - Journal of Drug Delivery Science and Technology
T1  - Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders
VL  - 67
DO  - 10.1016/j.jddst.2021.102981
ER  - 

@article{
author = "Ćirin-Varađan, Slobodanka and Đuriš, Jelena and Mirković, Miljana and Ivanović, Marija and Parojčić, Jelena and Aleksić, Ivana",
year = "2022",
abstract = "The introduction of the high-speed tableting machines and the lack of excipients with good flow and compaction properties required for direct compression process have increased research interest in the development of coprocessed excipients. Melt granulation, as an environmentally friendly and cost-effective method, has recently been recognized as a promising co-processing technique. The aim of the present study was to prepare lipid-based co-processed excipients by in situ fluidized bed melt granulation and to investigated their suitability for direct compression process. Lactose monohydrate was co-processed with glyceryl dibehenate (Compritol® 888 ATO) or glyceryl palmitostearate (Precirol® ATO 5), as lipophilic meltable binders. Besides the flowability testing, dynamic compaction analysis was applied for thorough investigation into the tableting properties of developed coprocessed excipients. Solid state characterization, performed by means of XRPD and DRIFT, confirmed the absence of chemical changes of the single components of co-processed excipients. Co-processed excipients showed improved flowability in comparison with single ingredients and corresponding physical mixtures. Novel co-processed excipients were found to have better tabletability profiles than physical mixtures of the ingredients, and were able to retain acceptable tensile strength values at high content of paracetamol in tableting mixture. Tablets with high tensile strength could be obtained with less work of compression needed in comparison with the commercial lactose-based excipients. Furthermore, novel lipid-based co-processed excipients were found to be highly superior regarding the antiadhesive and lubricating properties, with no additional lubricants required.",
publisher = "Elsevier B.V.",
journal = "Journal of Drug Delivery Science and Technology",
title = "Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders",
volume = "67",
doi = "10.1016/j.jddst.2021.102981"
}

Ćirin-Varađan, S., Đuriš, J., Mirković, M., Ivanović, M., Parojčić, J.,& Aleksić, I.. (2022). Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. in Journal of Drug Delivery Science and Technology
Elsevier B.V.., 67.
https://doi.org/10.1016/j.jddst.2021.102981

Ćirin-Varađan S, Đuriš J, Mirković M, Ivanović M, Parojčić J, Aleksić I. Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders. in Journal of Drug Delivery Science and Technology. 2022;67.
doi:10.1016/j.jddst.2021.102981 .

Ćirin-Varađan, Slobodanka, Đuriš, Jelena, Mirković, Miljana, Ivanović, Marija, Parojčić, Jelena, Aleksić, Ivana, "Comparative evaluation of mechanical properties of lactose-based excipients co-processed with lipophilic glycerides as meltable binders" in Journal of Drug Delivery Science and Technology, 67 (2022),
https://doi.org/10.1016/j.jddst.2021.102981 . .

TY  - CONF
AU  - Kurćubić, Ivana
AU  - Vajić, Una‐Jovana
AU  - Cvijić, Sandra
AU  - Crevar-Sakač, Milkica
AU  - Ibrić, Svetlana
AU  - Miloradović, Zoran
AU  - Mihailović‐Stanojević, Nevena
AU  - Ivanov, Milan
AU  - Karanović, Danijela
AU  - Jovović, Đurđica
AU  - Đuriš, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4512
AB  - Mucoadhesive buccal films can improve drug absorption by prolonging its retention
time on the buccal mucosa (1). The aim of the study was a comparative assessment of the
hemodynamic effects and pharmacokinetics of propranolol hydrochloride (PROP) after
buccal and oral administration in spontaneously hypertensive rats. Animals were divided
into 3 groups: Group I (control) received 0.5 mL of water with a gastric tube, group II
received an immediate-release 10 mg PROP tablet via gastric tube, and group III received a
mucoadhesive 10 mg PROP buccal film. Systolic (SP) and diastolic blood pressure (DP), and
heart rate (SF) were measured in rats, and pharmacokinetic PROP parameters, Cmax, tmax,
and AUC0 → 24, were calculated by noncompartmental analysis. Mucoadhesive buccal films
showed superior degree of absorption of PROP over immediate-release tablets (AUC0 → 24:
69.64 μgh/ml versus 24.61 μgh/ml). The tmax value was significantly higher in
mucoadhesive buccal films, which indicates a prolonged PROP release and longer
therapeutic effect (71.19h versus 29.73h). There was no statistically significant difference in
Cmax values between groups II and III of rats (4.74 μg ml versus 7.11 μg ml). Mucoadhesive
buccal films provide a more pronounced and long-lasting reduction primarily of SF
(reduction of 28-51% lasting from 10 minutes to the twelfth hour of testing), but also SP and
DP (between 15-30% from the first to the sixth hour of testing) compared to immediate-
release tablets. Mucoadhesive buccal films allow bypass/reduction of the extensive hepatic
first-pass metabolism, and consequently improve the therapeutic PROP effect.
AB  - Mukoadhezivni bukalni filmovi mogu poboljšati apsorpciju lekovite supstance
produžavajuć i vreme zadržavanja lekovitog preparata na bukalnoj sluznici (1). Cilj studije je
bila komparativna procena hemodinamskih efekata i farmakokinetike propranolol-
hidrohlorida (PROP) nakon bukalne i peroralne primene kod sponatano hipertenzivnih
pacova. Spontano hipertenzivni pacovi su podeljeni u 3 grupe: I (kontrolna) grupa je dobila
0,5 mL vode gastričnom sondom, II grupa je dobila tabletu sa trenutnim oslobađanjem sa 10
mg PROP gastričnom sondom i III grupa je dobila mukoadhezivni bukalni film sa 10 mg
PROP. Filmovi su pripremljeni korišćenjem polietilenoksida, hidroksipropilmetilceluloze i
polivinilalkohola kao film-formirajućih polimera sa mukoadhezivnim svojstvima. Pacovima
su mereni sistolni (SP) i dijastolni krvni pritisak (DP), srčana frekvencija (SF), a
neprostornom farmakokinetičkom analizom izračunati su parametri PROP: Cmax, t max i
AUC0→24 . Mukoadhezivni bukalni filmovi su pokazali superiornost u odnosu na tablete sa
trenutnim oslobađanjem u pogledu stepena apsorpcije PROP (AUC 0→24 : 69,64 μgh/ml
naspram 24,61 μgh/ml). Tmax vrednost je bila značajno veća kod mukoadhezivnih bukalnih
filmova što ukazuje na produženo oslobađanje PROP i duži terapijski efekat (71,19 h
naspram 29,73 h). Između II i II grupe pacova nema statistički značajne razlike u
vrednostima Cmax (4,74 μg/ml naspram 7,11 μg/ml). Mukoadhezivni bukalni filmovi izazivaju
izraženije i dugotrajnije smanjenje pre svega SF (smanjenje od 28-51% u trajanju od 10
minuta do dvanaestog sata ispitivanja), ali i SP i DP (između 15-30% od prvog do šestog sata
ispitivanja) u odnosu na tablete sa trenutnim oslobađanjem. Pripremljeni mukoadhezivni
bukalni filmovi omogućavaju zaobilazak/smanjenje ekstenzivnog metabolizma prvog
prolaza kroz jetru i posledično poboljšavaju terapijski efekat PROP.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Effects of acute application of mucoadhesive buccal films with propranolol hydrochloride in an animal model of essential hypertension
T1  - Efekti akutne primene mukoadhezivnih bukalnih filmova sa propranolol‐hidrohloridom u animalnom modelu esencijalne hipertenzije
VL  - 72
IS  - 4 suplement
SP  - S235
EP  - S236
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4512
ER  - 

@conference{
author = "Kurćubić, Ivana and Vajić, Una‐Jovana and Cvijić, Sandra and Crevar-Sakač, Milkica and Ibrić, Svetlana and Miloradović, Zoran and Mihailović‐Stanojević, Nevena and Ivanov, Milan and Karanović, Danijela and Jovović, Đurđica and Đuriš, Jelena",
year = "2022",
abstract = "Mucoadhesive buccal films can improve drug absorption by prolonging its retention
time on the buccal mucosa (1). The aim of the study was a comparative assessment of the
hemodynamic effects and pharmacokinetics of propranolol hydrochloride (PROP) after
buccal and oral administration in spontaneously hypertensive rats. Animals were divided
into 3 groups: Group I (control) received 0.5 mL of water with a gastric tube, group II
received an immediate-release 10 mg PROP tablet via gastric tube, and group III received a
mucoadhesive 10 mg PROP buccal film. Systolic (SP) and diastolic blood pressure (DP), and
heart rate (SF) were measured in rats, and pharmacokinetic PROP parameters, Cmax, tmax,
and AUC0 → 24, were calculated by noncompartmental analysis. Mucoadhesive buccal films
showed superior degree of absorption of PROP over immediate-release tablets (AUC0 → 24:
69.64 μgh/ml versus 24.61 μgh/ml). The tmax value was significantly higher in
mucoadhesive buccal films, which indicates a prolonged PROP release and longer
therapeutic effect (71.19h versus 29.73h). There was no statistically significant difference in
Cmax values between groups II and III of rats (4.74 μg ml versus 7.11 μg ml). Mucoadhesive
buccal films provide a more pronounced and long-lasting reduction primarily of SF
(reduction of 28-51% lasting from 10 minutes to the twelfth hour of testing), but also SP and
DP (between 15-30% from the first to the sixth hour of testing) compared to immediate-
release tablets. Mucoadhesive buccal films allow bypass/reduction of the extensive hepatic
first-pass metabolism, and consequently improve the therapeutic PROP effect., Mukoadhezivni bukalni filmovi mogu poboljšati apsorpciju lekovite supstance
produžavajuć i vreme zadržavanja lekovitog preparata na bukalnoj sluznici (1). Cilj studije je
bila komparativna procena hemodinamskih efekata i farmakokinetike propranolol-
hidrohlorida (PROP) nakon bukalne i peroralne primene kod sponatano hipertenzivnih
pacova. Spontano hipertenzivni pacovi su podeljeni u 3 grupe: I (kontrolna) grupa je dobila
0,5 mL vode gastričnom sondom, II grupa je dobila tabletu sa trenutnim oslobađanjem sa 10
mg PROP gastričnom sondom i III grupa je dobila mukoadhezivni bukalni film sa 10 mg
PROP. Filmovi su pripremljeni korišćenjem polietilenoksida, hidroksipropilmetilceluloze i
polivinilalkohola kao film-formirajućih polimera sa mukoadhezivnim svojstvima. Pacovima
su mereni sistolni (SP) i dijastolni krvni pritisak (DP), srčana frekvencija (SF), a
neprostornom farmakokinetičkom analizom izračunati su parametri PROP: Cmax, t max i
AUC0→24 . Mukoadhezivni bukalni filmovi su pokazali superiornost u odnosu na tablete sa
trenutnim oslobađanjem u pogledu stepena apsorpcije PROP (AUC 0→24 : 69,64 μgh/ml
naspram 24,61 μgh/ml). Tmax vrednost je bila značajno veća kod mukoadhezivnih bukalnih
filmova što ukazuje na produženo oslobađanje PROP i duži terapijski efekat (71,19 h
naspram 29,73 h). Između II i II grupe pacova nema statistički značajne razlike u
vrednostima Cmax (4,74 μg/ml naspram 7,11 μg/ml). Mukoadhezivni bukalni filmovi izazivaju
izraženije i dugotrajnije smanjenje pre svega SF (smanjenje od 28-51% u trajanju od 10
minuta do dvanaestog sata ispitivanja), ali i SP i DP (između 15-30% od prvog do šestog sata
ispitivanja) u odnosu na tablete sa trenutnim oslobađanjem. Pripremljeni mukoadhezivni
bukalni filmovi omogućavaju zaobilazak/smanjenje ekstenzivnog metabolizma prvog
prolaza kroz jetru i posledično poboljšavaju terapijski efekat PROP.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Effects of acute application of mucoadhesive buccal films with propranolol hydrochloride in an animal model of essential hypertension, Efekti akutne primene mukoadhezivnih bukalnih filmova sa propranolol‐hidrohloridom u animalnom modelu esencijalne hipertenzije",
volume = "72",
number = "4 suplement",
pages = "S235-S236",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4512"
}

Kurćubić, I., Vajić, U., Cvijić, S., Crevar-Sakač, M., Ibrić, S., Miloradović, Z., Mihailović‐Stanojević, N., Ivanov, M., Karanović, D., Jovović, Đ.,& Đuriš, J.. (2022). Effects of acute application of mucoadhesive buccal films with propranolol hydrochloride in an animal model of essential hypertension. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S235-S236.
https://hdl.handle.net/21.15107/rcub_farfar_4512

Kurćubić I, Vajić U, Cvijić S, Crevar-Sakač M, Ibrić S, Miloradović Z, Mihailović‐Stanojević N, Ivanov M, Karanović D, Jovović Đ, Đuriš J. Effects of acute application of mucoadhesive buccal films with propranolol hydrochloride in an animal model of essential hypertension. in Arhiv za farmaciju. 2022;72(4 suplement):S235-S236.
https://hdl.handle.net/21.15107/rcub_farfar_4512 .

Kurćubić, Ivana, Vajić, Una‐Jovana, Cvijić, Sandra, Crevar-Sakač, Milkica, Ibrić, Svetlana, Miloradović, Zoran, Mihailović‐Stanojević, Nevena, Ivanov, Milan, Karanović, Danijela, Jovović, Đurđica, Đuriš, Jelena, "Effects of acute application of mucoadhesive buccal films with propranolol hydrochloride in an animal model of essential hypertension" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S235-S236,
https://hdl.handle.net/21.15107/rcub_farfar_4512 .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Pilović, Jovana
AU  - Džunić, Marina
AU  - Cvijić, Sandra
AU  - Ibrić, Svetlana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4412
AB  - Text mining (TM) applications in the field of biomedicine are gaining great interest. TM
tools can facilitate formulation development by analyzing textual information from patent
databases, scientific articles, summary of products characteristics, etc. The aim of this study was
to utilize TM tools to perform qualitative analysis of paracetamol (PAR) and ibuprofen (IBU)
formulations, in terms of identifying and evaluating the presence of excipients specific to the
active pharmaceutical ingredient (API) and/or dosage form. A total of 152 products were
analyzed. Web-scraping was used to retrieve the data, and Python-based open-source software
Orange 3.31.1 was used for TM and statistical analysis (ANOVA) of the obtained results. The
majority of marketed products for both APIs were tablets. The predominant excipients in all tablet
formulations were povidone, starch, microcrystalline cellulose and hypromellose. Povidone,
stearic acid, potassium sorbate, maize starch and pregelatinized starch occurred more frequently
in PAR tablets. On the other hand, titanium dioxide, lactose, shellac, sucrose and ammonium
hydroxide were specific to IBU tablets. PAR oral suspensions more frequently contained
dispersible cellulose; liquid sorbitol; methyl and propyl parahydroxybenzoate, glycerol and
acesulfame potassium. Specific excipients in other PAR dosage forms, such as effervescent
tablets, hard capsules, oral powders, solutions and suspensions, as well as IBU gels and soft
capsules, were also evaluated.
AB  - Primena text mining (TM) alata u oblasti biomedicine postaje sve značajnija. TM alati mogu da olakšaju razvoj formulacija, tako što omogućavaju analizu tekstualnih informacija iz patentnih baza, naučnih članaka, sažetaka karakteristika lekova, itd. Cilj ovog rada bila je primena TM alata za kvalitativnu analizu formulacija paracetamola (PAR) i ibuprofena (IBU), u smislu identifikacije i procene prisustva ekscipijenasa koji su karakteristični za lekovitu supstancu i/ili farmaceutski oblik. Ukupno je analiziran sastav 152 preparata. Web-scraping je primenjen za prikupljanje podataka, a Orange 3.31.1, softver otvorenog koda zasnovan na programskom jeziku Python, primenjen je za TM i statističku analizu (ANOVA) dobijenih rezultata. Većina analiziranih formulacija za obe lekovite supstance bile su tablete, a najzastupljeniji ekscipijensi u njima su bili povidon, skrob, mikrokristalna celuloza i hipromeloza. Povidon, stearinska kiselina, kalijum sorbat, kukuruzni skrob i pregelirani skrob se češće pronalaze u formulacijama PAR tableta. Titanijum-dioksid, laktoza, šelak, saharoza i amonijum hidroksid su specifični za IBU tablete. PAR peroralne suspenzije su češće sadržale disperzibilnu celulozu; tečni sorbitol; metil-i propil parahidroksibenzoat, glicerol i acesulfam-kalijum. Takođe su identifikovani i specifični ekscipijensi za PAR efervescentne tablete, tvrde kapsule, peroralne praškove, rastvore i suspenzije, kao i za IBU gelove i meke kapsule.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Application of text-mining techniques for extraction and analysis of paracetamol and ibuprofen marketed products’ qualitative composition
T1  - Primena tehnika za sistematizovanu obradu tekstualnih informacija u cilju analize kvalitativnog sastava registrovanih preparata paracetamola i ibuprofena
VL  - 72
IS  - 6
SP  - 689
EP  - 700
DO  - 10.5937/arhfarm72-40397
ER  - 

@article{
author = "Đuriš, Jelena and Pilović, Jovana and Džunić, Marina and Cvijić, Sandra and Ibrić, Svetlana",
year = "2022",
abstract = "Text mining (TM) applications in the field of biomedicine are gaining great interest. TM
tools can facilitate formulation development by analyzing textual information from patent
databases, scientific articles, summary of products characteristics, etc. The aim of this study was
to utilize TM tools to perform qualitative analysis of paracetamol (PAR) and ibuprofen (IBU)
formulations, in terms of identifying and evaluating the presence of excipients specific to the
active pharmaceutical ingredient (API) and/or dosage form. A total of 152 products were
analyzed. Web-scraping was used to retrieve the data, and Python-based open-source software
Orange 3.31.1 was used for TM and statistical analysis (ANOVA) of the obtained results. The
majority of marketed products for both APIs were tablets. The predominant excipients in all tablet
formulations were povidone, starch, microcrystalline cellulose and hypromellose. Povidone,
stearic acid, potassium sorbate, maize starch and pregelatinized starch occurred more frequently
in PAR tablets. On the other hand, titanium dioxide, lactose, shellac, sucrose and ammonium
hydroxide were specific to IBU tablets. PAR oral suspensions more frequently contained
dispersible cellulose; liquid sorbitol; methyl and propyl parahydroxybenzoate, glycerol and
acesulfame potassium. Specific excipients in other PAR dosage forms, such as effervescent
tablets, hard capsules, oral powders, solutions and suspensions, as well as IBU gels and soft
capsules, were also evaluated., Primena text mining (TM) alata u oblasti biomedicine postaje sve značajnija. TM alati mogu da olakšaju razvoj formulacija, tako što omogućavaju analizu tekstualnih informacija iz patentnih baza, naučnih članaka, sažetaka karakteristika lekova, itd. Cilj ovog rada bila je primena TM alata za kvalitativnu analizu formulacija paracetamola (PAR) i ibuprofena (IBU), u smislu identifikacije i procene prisustva ekscipijenasa koji su karakteristični za lekovitu supstancu i/ili farmaceutski oblik. Ukupno je analiziran sastav 152 preparata. Web-scraping je primenjen za prikupljanje podataka, a Orange 3.31.1, softver otvorenog koda zasnovan na programskom jeziku Python, primenjen je za TM i statističku analizu (ANOVA) dobijenih rezultata. Većina analiziranih formulacija za obe lekovite supstance bile su tablete, a najzastupljeniji ekscipijensi u njima su bili povidon, skrob, mikrokristalna celuloza i hipromeloza. Povidon, stearinska kiselina, kalijum sorbat, kukuruzni skrob i pregelirani skrob se češće pronalaze u formulacijama PAR tableta. Titanijum-dioksid, laktoza, šelak, saharoza i amonijum hidroksid su specifični za IBU tablete. PAR peroralne suspenzije su češće sadržale disperzibilnu celulozu; tečni sorbitol; metil-i propil parahidroksibenzoat, glicerol i acesulfam-kalijum. Takođe su identifikovani i specifični ekscipijensi za PAR efervescentne tablete, tvrde kapsule, peroralne praškove, rastvore i suspenzije, kao i za IBU gelove i meke kapsule.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Application of text-mining techniques for extraction and analysis of paracetamol and ibuprofen marketed products’ qualitative composition, Primena tehnika za sistematizovanu obradu tekstualnih informacija u cilju analize kvalitativnog sastava registrovanih preparata paracetamola i ibuprofena",
volume = "72",
number = "6",
pages = "689-700",
doi = "10.5937/arhfarm72-40397"
}

Đuriš, J., Pilović, J., Džunić, M., Cvijić, S.,& Ibrić, S.. (2022). Application of text-mining techniques for extraction and analysis of paracetamol and ibuprofen marketed products’ qualitative composition. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 689-700.
https://doi.org/10.5937/arhfarm72-40397

Đuriš J, Pilović J, Džunić M, Cvijić S, Ibrić S. Application of text-mining techniques for extraction and analysis of paracetamol and ibuprofen marketed products’ qualitative composition. in Arhiv za farmaciju. 2022;72(6):689-700.
doi:10.5937/arhfarm72-40397 .

Đuriš, Jelena, Pilović, Jovana, Džunić, Marina, Cvijić, Sandra, Ibrić, Svetlana, "Application of text-mining techniques for extraction and analysis of paracetamol and ibuprofen marketed products’ qualitative composition" in Arhiv za farmaciju, 72, no. 6 (2022):689-700,
https://doi.org/10.5937/arhfarm72-40397 . .

TY  - CONF
AU  - Lazić, Irina
AU  - Kučević, Sabina
AU  - Ćirin-Varađan, Slobodanka
AU  - Aleksić, Ivana
AU  - Đuriš, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4569
AB  - Formulation of modified-release ibuprofen tablets presents a challenge due to its high
dose, limited compressibility and compactibility. The potential for preparing ibuprofen
modified release matrix tablets, by direct compression procedure using co-processed
excipients (1, 2), was evaluated. Co-processed excipients of hydrophilic and lipid properties
were used. Commercially available co-processed excipient based on
hydroxypropylmethylcellulose and lactose (RetaLac ®), as well as co-processed excipient
made in-house, using lipid matrix forming agent based on glyceryl palmitostearate
(Precirol® ) and lactose were used. The influence of co-processed excipient type, ibuprofen
ammount in tablets (25% and 50%) and the compression load (100 and 500 kg) on the
mechanical properties of the hydrophilic or lipid matrix tablets was evaluated. Also,
ibuprofen release rate was investigated in a rotating paddle apparatus with medium change
(0.1M HCl and phosphate buffer pH 6.8). The tensile strength of formulations was in the
range of 0.5-2 MPa. The compression load and the co-processed excipient type showed a
significant effect on tensile strength. Ibuprofen was released in a sustained manner from all
formulations, with the amount released after 8 hours varying from 35 to 80%, depending on
the matrix forming material type. The release of ibuprofen from lipid matrix tablets was
slower compared to hydrophilic tablets, with neither the compression load nor the ibuprofen
content showing a significant effect. Zero-order kinetics was achieved from both types of
matrix tablets. Based on the obtained results, it can be concluded that co-processed
excipients enable direct compression of ibuprofen modified release hydrophilic and lipid
matrix tablets.
AB  - Formulacija tableta sa modifikovanim oslobađanjem ibuprofena predstavlja izazov
zbog visoke doze lekovite supstance ograničene kompresibilnosti i kompaktibilnosti. U ovom
radu procenjena je mogućnost izrade matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije uz primenu koprocesovanih ekscipijenasa (1, 2).
Upotrebljeni su koprocesovani ekscipijensi hidrofilnih i lipidnih karakteristika. Korišćeni su
komercijalno dostupan koprocesovani ekscipijens na bazi hidroksipropilmetilceluloze i
laktoze (RetaLac® ), kao i koprocesovani ekscipijens izrađen u laboratorijskim uslovima, kao
lipidno matriks formirajuće sredstvo na bazi glicerilpalmitostearata (Precirol ®) i laktoze.
Praćen je uticaj vrste koprocesovanog ekscipijensa, udela ibuprofena u tabletama (25%,
odnosno 50%) i opterećenja pri kompresiji (100, odnosno 500 kg) na mehaničke
karakteristike izrađenih hidrofilnih, odnosno lipidnih matriks tableta. Takođe, ispitivana je
brzina oslobađanja ibuprofena iz pripremljenih matriks tableta u aparaturi sa rotirajućim
lopaticama uz izmenu medijuma (0,1M HCl i fosfatni pufer pH 6,8). Zatezna čvrstoća
ispitivanih formulacija je bila u opsegu ~ 0.5-2 MPa. Opterećenje pri kompresiji i tip
koprocesovanog ekscipijensa su pokazali značajan uticaj na zateznu čvrstoću. Ibuprofen se iz
svih formulacija oslobađao usporeno, pri čemu je količina oslobođena nakon 8 sati
ispitivanja varirala od 35 do 80%, u zavisnosti od prirode matriks formirajućeg materijala.
Oslobađanje ibuprofena iz lipidnih matriks tableta je bilo sporije u poređenju sa hidrofilnim
tabletama, pri čemu ni opterećenje pri kompresiji ni udeo ibuprofena nisu pokazali značajan
uticaj. Iz oba tipa matriks tableta postignuto je oslobađanje ibuprofena kinetikom nultog
reda. Na osnovu dobijenih rezultata može se zaključiti da koprocesovani ekscipijensi
omogućavaju izradu hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients
T1  - Formulacija hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem ibuprofena primenom koprocesovanih ekscipijenasa
VL  - 72
IS  - 4 suplement
SP  - S3400
EP  - S401
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4569
ER  - 

@conference{
author = "Lazić, Irina and Kučević, Sabina and Ćirin-Varađan, Slobodanka and Aleksić, Ivana and Đuriš, Jelena",
year = "2022",
abstract = "Formulation of modified-release ibuprofen tablets presents a challenge due to its high
dose, limited compressibility and compactibility. The potential for preparing ibuprofen
modified release matrix tablets, by direct compression procedure using co-processed
excipients (1, 2), was evaluated. Co-processed excipients of hydrophilic and lipid properties
were used. Commercially available co-processed excipient based on
hydroxypropylmethylcellulose and lactose (RetaLac ®), as well as co-processed excipient
made in-house, using lipid matrix forming agent based on glyceryl palmitostearate
(Precirol® ) and lactose were used. The influence of co-processed excipient type, ibuprofen
ammount in tablets (25% and 50%) and the compression load (100 and 500 kg) on the
mechanical properties of the hydrophilic or lipid matrix tablets was evaluated. Also,
ibuprofen release rate was investigated in a rotating paddle apparatus with medium change
(0.1M HCl and phosphate buffer pH 6.8). The tensile strength of formulations was in the
range of 0.5-2 MPa. The compression load and the co-processed excipient type showed a
significant effect on tensile strength. Ibuprofen was released in a sustained manner from all
formulations, with the amount released after 8 hours varying from 35 to 80%, depending on
the matrix forming material type. The release of ibuprofen from lipid matrix tablets was
slower compared to hydrophilic tablets, with neither the compression load nor the ibuprofen
content showing a significant effect. Zero-order kinetics was achieved from both types of
matrix tablets. Based on the obtained results, it can be concluded that co-processed
excipients enable direct compression of ibuprofen modified release hydrophilic and lipid
matrix tablets., Formulacija tableta sa modifikovanim oslobađanjem ibuprofena predstavlja izazov
zbog visoke doze lekovite supstance ograničene kompresibilnosti i kompaktibilnosti. U ovom
radu procenjena je mogućnost izrade matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije uz primenu koprocesovanih ekscipijenasa (1, 2).
Upotrebljeni su koprocesovani ekscipijensi hidrofilnih i lipidnih karakteristika. Korišćeni su
komercijalno dostupan koprocesovani ekscipijens na bazi hidroksipropilmetilceluloze i
laktoze (RetaLac® ), kao i koprocesovani ekscipijens izrađen u laboratorijskim uslovima, kao
lipidno matriks formirajuće sredstvo na bazi glicerilpalmitostearata (Precirol ®) i laktoze.
Praćen je uticaj vrste koprocesovanog ekscipijensa, udela ibuprofena u tabletama (25%,
odnosno 50%) i opterećenja pri kompresiji (100, odnosno 500 kg) na mehaničke
karakteristike izrađenih hidrofilnih, odnosno lipidnih matriks tableta. Takođe, ispitivana je
brzina oslobađanja ibuprofena iz pripremljenih matriks tableta u aparaturi sa rotirajućim
lopaticama uz izmenu medijuma (0,1M HCl i fosfatni pufer pH 6,8). Zatezna čvrstoća
ispitivanih formulacija je bila u opsegu ~ 0.5-2 MPa. Opterećenje pri kompresiji i tip
koprocesovanog ekscipijensa su pokazali značajan uticaj na zateznu čvrstoću. Ibuprofen se iz
svih formulacija oslobađao usporeno, pri čemu je količina oslobođena nakon 8 sati
ispitivanja varirala od 35 do 80%, u zavisnosti od prirode matriks formirajućeg materijala.
Oslobađanje ibuprofena iz lipidnih matriks tableta je bilo sporije u poređenju sa hidrofilnim
tabletama, pri čemu ni opterećenje pri kompresiji ni udeo ibuprofena nisu pokazali značajan
uticaj. Iz oba tipa matriks tableta postignuto je oslobađanje ibuprofena kinetikom nultog
reda. Na osnovu dobijenih rezultata može se zaključiti da koprocesovani ekscipijensi
omogućavaju izradu hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem
ibuprofena postupkom direktne kompresije.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients, Formulacija hidrofilnih i lipidnih matriks tableta sa modifikovanim oslobađanjem ibuprofena primenom koprocesovanih ekscipijenasa",
volume = "72",
number = "4 suplement",
pages = "S3400-S401",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4569"
}

Lazić, I., Kučević, S., Ćirin-Varađan, S., Aleksić, I.,& Đuriš, J.. (2022). Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S3400-S401.
https://hdl.handle.net/21.15107/rcub_farfar_4569

Lazić I, Kučević S, Ćirin-Varađan S, Aleksić I, Đuriš J. Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients. in Arhiv za farmaciju. 2022;72(4 suplement):S3400-S401.
https://hdl.handle.net/21.15107/rcub_farfar_4569 .

Lazić, Irina, Kučević, Sabina, Ćirin-Varađan, Slobodanka, Aleksić, Ivana, Đuriš, Jelena, "Formulation of ibuprofen-modified release hydrophilic and lipid matrix tablets using co-processed excipients" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S3400-S401,
https://hdl.handle.net/21.15107/rcub_farfar_4569 .

TY  - CONF
AU  - Đuriš, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4454
AB  - QbD (Quality by Design) and PAT (Process Analytical Technologies) concepts
significantly facilitate the implementation of new technologies in the pharmaceuticals ́
formulation and processes development. From simple formulations to complex delivery
systems, QbD approach allows identification of the critical process parameters and material
properties affecting the pharmaceutical products quality. For the analysis of complex
relationships, establishment of the design space and, most importantly, control strategies,
modeling and simulation tools are of paramount importance (1). Hybrid models, which
combine elements of mechanistic modeling and empirical approach, are particularly
important for processing of large amount of data collected by monitoring the process with
PAT tools. This enables the establishment of a virtual copy (digital twin), or cyber-physical
system, which facilitates the optimization and continuous improvement of the process.
Artificial intelligence techniques in formulation and process innovations involve different
machine learning algorithms. They are used to solve regression or classification problems
and to process data of various types (numerical, textual, images, etc). Artificial neural
networks can be applied from the initial formulation development to the production of
validation batches for which the bioequivalence predicted by models has been confirmed (2).
Artificial intelligence technology is also very important for the design and application of
virtual copies of continuous production processes or complex biotechnological processes.
This facilitates the implementation of the Real Time Release Testing (RTRT) strategy. It is to
be expected that good modeling practices will be more precisely defined through the official
regulatory guidelines, in the context of the application of artificial intelligence techniques.
AB  - QbD (Quality by Design) i PAT (Process Analytical Technologies) koncepti značajno
olakšavaju implementaciju novih tehnologija u razvoju formulacija i procesa za proizvodnju
farmaceutskih preparata. Оd jednostavnih formulacija do kompleksnih nosača, QbD pristup
omogućava identifikaciju kritičnih procesnih parametara i karakteristika materijala koji
utiču na kvalitet farmaceutskih proizvoda. Za analizu kompleksnih veza, uspostavljanje
design space-a i, što je najznačajnije, kontrolne strategije od izuzetnog značaja su alati za
modelovanje i simulacije (1). Hibridni modeli, koji kombinuju elemente mehanističkog
modelovanja i empirijskog pristupa su naročito značajni za obradu velikog obima podataka
koji se prikupljanju praćenjem procesa PAT alatima. Na taj način se omogućava
uspostavljanje virtuelne kopije (digital twin), odnosno sajber-fizičkog sistema, čime je
olakšana optimizacija i kontinuirano unapređenje procesa. Tehnike veštačke inteligencije
koje se primenjuju u kontekstu implementacije QbD i PAT alata u formulacionim i procesnim
inovacijama podrazumevaju različite algoritme mašinskog učenja. Koriste se za rešavanje
regresionih ili klasifikacionih problema i obradu podataka različitog tipa (numerički,
teksutalni, zapisi u slikovnom formatu, itd). Veštačke neuronske mreže mogu da se primene
od inicijalnog razvoja formulacije do proizvodnje validacionih serija za koje je potvrđena
bioekvivalentnost predviđena modelima (2). Tehničke veštačke inteligencije su takođe
veoma značajne za dizajn i primenu virtuelnih kopija procesa kontinuirane proizvodnje ili
kompleksnih biotehnoloških procesa. Na taj način se olakšava implementacija strategije
puštanja leka u realnom vremenu (Real Time Release Testing, RTRT). Za očekivati je da se i
kroz smernice regulatornih tela preciznije definišu dobre prakse u modelovanju, u kontekstu
primene tehnika veštačke inteligencije u podršci QbD i PAT koncepata.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Formulations and process innovations: QbD approach and PAT tools supported by artificial intelligence techniques
T1  - Inovacije u formulaciji i procesu: QbD pristup i PAT alati podržani tehnikama veštačke inteligencije
VL  - 72
IS  - 4 suplement
SP  - S79
EP  - S80
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4454
ER  - 

@conference{
author = "Đuriš, Jelena",
year = "2022",
abstract = "QbD (Quality by Design) and PAT (Process Analytical Technologies) concepts
significantly facilitate the implementation of new technologies in the pharmaceuticals ́
formulation and processes development. From simple formulations to complex delivery
systems, QbD approach allows identification of the critical process parameters and material
properties affecting the pharmaceutical products quality. For the analysis of complex
relationships, establishment of the design space and, most importantly, control strategies,
modeling and simulation tools are of paramount importance (1). Hybrid models, which
combine elements of mechanistic modeling and empirical approach, are particularly
important for processing of large amount of data collected by monitoring the process with
PAT tools. This enables the establishment of a virtual copy (digital twin), or cyber-physical
system, which facilitates the optimization and continuous improvement of the process.
Artificial intelligence techniques in formulation and process innovations involve different
machine learning algorithms. They are used to solve regression or classification problems
and to process data of various types (numerical, textual, images, etc). Artificial neural
networks can be applied from the initial formulation development to the production of
validation batches for which the bioequivalence predicted by models has been confirmed (2).
Artificial intelligence technology is also very important for the design and application of
virtual copies of continuous production processes or complex biotechnological processes.
This facilitates the implementation of the Real Time Release Testing (RTRT) strategy. It is to
be expected that good modeling practices will be more precisely defined through the official
regulatory guidelines, in the context of the application of artificial intelligence techniques., QbD (Quality by Design) i PAT (Process Analytical Technologies) koncepti značajno
olakšavaju implementaciju novih tehnologija u razvoju formulacija i procesa za proizvodnju
farmaceutskih preparata. Оd jednostavnih formulacija do kompleksnih nosača, QbD pristup
omogućava identifikaciju kritičnih procesnih parametara i karakteristika materijala koji
utiču na kvalitet farmaceutskih proizvoda. Za analizu kompleksnih veza, uspostavljanje
design space-a i, što je najznačajnije, kontrolne strategije od izuzetnog značaja su alati za
modelovanje i simulacije (1). Hibridni modeli, koji kombinuju elemente mehanističkog
modelovanja i empirijskog pristupa su naročito značajni za obradu velikog obima podataka
koji se prikupljanju praćenjem procesa PAT alatima. Na taj način se omogućava
uspostavljanje virtuelne kopije (digital twin), odnosno sajber-fizičkog sistema, čime je
olakšana optimizacija i kontinuirano unapređenje procesa. Tehnike veštačke inteligencije
koje se primenjuju u kontekstu implementacije QbD i PAT alata u formulacionim i procesnim
inovacijama podrazumevaju različite algoritme mašinskog učenja. Koriste se za rešavanje
regresionih ili klasifikacionih problema i obradu podataka različitog tipa (numerički,
teksutalni, zapisi u slikovnom formatu, itd). Veštačke neuronske mreže mogu da se primene
od inicijalnog razvoja formulacije do proizvodnje validacionih serija za koje je potvrđena
bioekvivalentnost predviđena modelima (2). Tehničke veštačke inteligencije su takođe
veoma značajne za dizajn i primenu virtuelnih kopija procesa kontinuirane proizvodnje ili
kompleksnih biotehnoloških procesa. Na taj način se olakšava implementacija strategije
puštanja leka u realnom vremenu (Real Time Release Testing, RTRT). Za očekivati je da se i
kroz smernice regulatornih tela preciznije definišu dobre prakse u modelovanju, u kontekstu
primene tehnika veštačke inteligencije u podršci QbD i PAT koncepata.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Formulations and process innovations: QbD approach and PAT tools supported by artificial intelligence techniques, Inovacije u formulaciji i procesu: QbD pristup i PAT alati podržani tehnikama veštačke inteligencije",
volume = "72",
number = "4 suplement",
pages = "S79-S80",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4454"
}

Đuriš, J.. (2022). Formulations and process innovations: QbD approach and PAT tools supported by artificial intelligence techniques. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S79-S80.
https://hdl.handle.net/21.15107/rcub_farfar_4454

Đuriš J. Formulations and process innovations: QbD approach and PAT tools supported by artificial intelligence techniques. in Arhiv za farmaciju. 2022;72(4 suplement):S79-S80.
https://hdl.handle.net/21.15107/rcub_farfar_4454 .

Đuriš, Jelena, "Formulations and process innovations: QbD approach and PAT tools supported by artificial intelligence techniques" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S79-S80,
https://hdl.handle.net/21.15107/rcub_farfar_4454 .

TY  - JOUR
AU  - Kovačević, Jovana
AU  - Kovačević, Aleksandar
AU  - Miletić, Tijana
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4413
AB  - Understanding the effect of the characteristics of formulation and process parameters on
the physicochemical properties of a pharmaceutical product is very significant for the
development of solid dosage forms, as the knowledge gained on small scale batches in the early
phase of development is used in the later phases of product lifecycle or in the development of
other products. One of the approaches for gaining a better understanding of the effects of the
formulation and production process on the quality of the finished product is to apply a
systematical approach which concerns performing experiments according to a predefined factorial
or fractional factorial experimental plan. However, often it is the case that there are available data
gathered in a non-systematic way, because experiments were not performed according to a
predetermined experimental plan. In such a case, data mining techniques could be used to extract
useful data from the historical data set. In this research, the possibility of using several data mining
techniques to build models that describe the effect of formulation characteristics on acid resistance
and dissolution profile of a model drug from gastro-resistant pellets. The model drug used in the
research is duloxetine hydrochloride from the group of antidepressants. It belongs to the BCS 2
class of active pharmaceutical ingredients, and it is therefore necessary for the release profile of
duloxetine to be characterized by a higher number of tested time points. The developed models
can be used for planning future laboratory trials, or in the development of other products.
AB  - Razumevanje uticaja karakteristika formulacije i procesnih parametara na fizičkohemijske osobine farmaceutskog proizvoda je vrlo značajno u razvoju čvrstih doziranih oblika jer se znanje stečeno u fazi razvoja koristi i u svim sledećim fazama životnog ciklusa proizvoda, a može da se primeni i u razvoju drugih proizvoda. Jedan pristup ka postizanju boljeg poznavanja proizvoda i procesa je primena sistematičnog pristupa koji podrazumeva izvođenje eksperimenata u skladu sa predefinisanim faktorijalnim ili frakcionim faktorijalnim eksperiementalnim planom. Međutim, čest je slučaj da dostupni podaci nisu prikupljeni na sistematičan način zato što eksperimenti nisu izvođeni po predefinisanom planu. Tada se mogu primeniti tehnike istraživanja i analize podataka da bi se iz seta istorijskih podataka izdvojili korisni podaci. U ovom istraživanju smo ispitali mogućnost korišćenja različitih tehnika istraživanja i analize podataka za razvoj modela koji opisuju efekte formulacije na gastrorezistenciju i profil oslobađanja model supstance iz gastrorezistentnih peleta. Model supstanca je duloksetin hidrohlorid iz grupe antidepresiva. Pripada BCS 2 klasi lekovitih supstanci, te je poželjno da profil brzine rastvaranja duloksetina iz peleta bude okarakterisan većim brojem vremenskih tačaka. Razvijeni modeli se mogu koristiti za planiranje narednih proba ili u razvoju drugih proizvoda.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Data mining techniques applied in the analysis of historical data
T1  - Tehnika istraživanja i analize podataka primenjena u analizi istorijskih podataka
VL  - 72
IS  - 6
SP  - 701
EP  - 715
DO  - 10.5937/arhfarm72-41368
ER  - 

@article{
author = "Kovačević, Jovana and Kovačević, Aleksandar and Miletić, Tijana and Đuriš, Jelena and Ibrić, Svetlana",
year = "2022",
abstract = "Understanding the effect of the characteristics of formulation and process parameters on
the physicochemical properties of a pharmaceutical product is very significant for the
development of solid dosage forms, as the knowledge gained on small scale batches in the early
phase of development is used in the later phases of product lifecycle or in the development of
other products. One of the approaches for gaining a better understanding of the effects of the
formulation and production process on the quality of the finished product is to apply a
systematical approach which concerns performing experiments according to a predefined factorial
or fractional factorial experimental plan. However, often it is the case that there are available data
gathered in a non-systematic way, because experiments were not performed according to a
predetermined experimental plan. In such a case, data mining techniques could be used to extract
useful data from the historical data set. In this research, the possibility of using several data mining
techniques to build models that describe the effect of formulation characteristics on acid resistance
and dissolution profile of a model drug from gastro-resistant pellets. The model drug used in the
research is duloxetine hydrochloride from the group of antidepressants. It belongs to the BCS 2
class of active pharmaceutical ingredients, and it is therefore necessary for the release profile of
duloxetine to be characterized by a higher number of tested time points. The developed models
can be used for planning future laboratory trials, or in the development of other products., Razumevanje uticaja karakteristika formulacije i procesnih parametara na fizičkohemijske osobine farmaceutskog proizvoda je vrlo značajno u razvoju čvrstih doziranih oblika jer se znanje stečeno u fazi razvoja koristi i u svim sledećim fazama životnog ciklusa proizvoda, a može da se primeni i u razvoju drugih proizvoda. Jedan pristup ka postizanju boljeg poznavanja proizvoda i procesa je primena sistematičnog pristupa koji podrazumeva izvođenje eksperimenata u skladu sa predefinisanim faktorijalnim ili frakcionim faktorijalnim eksperiementalnim planom. Međutim, čest je slučaj da dostupni podaci nisu prikupljeni na sistematičan način zato što eksperimenti nisu izvođeni po predefinisanom planu. Tada se mogu primeniti tehnike istraživanja i analize podataka da bi se iz seta istorijskih podataka izdvojili korisni podaci. U ovom istraživanju smo ispitali mogućnost korišćenja različitih tehnika istraživanja i analize podataka za razvoj modela koji opisuju efekte formulacije na gastrorezistenciju i profil oslobađanja model supstance iz gastrorezistentnih peleta. Model supstanca je duloksetin hidrohlorid iz grupe antidepresiva. Pripada BCS 2 klasi lekovitih supstanci, te je poželjno da profil brzine rastvaranja duloksetina iz peleta bude okarakterisan većim brojem vremenskih tačaka. Razvijeni modeli se mogu koristiti za planiranje narednih proba ili u razvoju drugih proizvoda.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Data mining techniques applied in the analysis of historical data, Tehnika istraživanja i analize podataka primenjena u analizi istorijskih podataka",
volume = "72",
number = "6",
pages = "701-715",
doi = "10.5937/arhfarm72-41368"
}

Kovačević, J., Kovačević, A., Miletić, T., Đuriš, J.,& Ibrić, S.. (2022). Data mining techniques applied in the analysis of historical data. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(6), 701-715.
https://doi.org/10.5937/arhfarm72-41368

Kovačević J, Kovačević A, Miletić T, Đuriš J, Ibrić S. Data mining techniques applied in the analysis of historical data. in Arhiv za farmaciju. 2022;72(6):701-715.
doi:10.5937/arhfarm72-41368 .

Kovačević, Jovana, Kovačević, Aleksandar, Miletić, Tijana, Đuriš, Jelena, Ibrić, Svetlana, "Data mining techniques applied in the analysis of historical data" in Arhiv za farmaciju, 72, no. 6 (2022):701-715,
https://doi.org/10.5937/arhfarm72-41368 . .

TY  - JOUR
AU  - Madžarević, Marijana
AU  - Medarević, Đorđe
AU  - Pavlović, Stefan
AU  - Ivković, Branka
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5544
AB  - Selective laser sintering (SLS) is a rapid prototyping technique for the production of
three-dimensional objects through selectively sintering powder-based layer materials. The aim
of the study was to investigate the effect of energy density (ED) and formulation factors on the
printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors,
ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR
results revealed that there was no interaction between irbesartan and the applied excipients. DSC
results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a
significant influence on tablets’ physical, mechanical, and morphological characteristics. Adding
lactose monohydrate enabled faster drug release while reducing the possibility for printing with
different laser speeds. However, formulations with crospovidone were printable with a wider range
of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS
tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results
suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical
formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however,
it needs to be governed by the composition of the whole formulation.
PB  - MDPI
T2  - Pharmaceutics
T1  - Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model
VL  - 13
IS  - 11
SP  - 1969
DO  - 10.3390/pharmaceutics13111969
ER  - 

@article{
author = "Madžarević, Marijana and Medarević, Đorđe and Pavlović, Stefan and Ivković, Branka and Đuriš, Jelena and Ibrić, Svetlana",
year = "2021",
abstract = "Selective laser sintering (SLS) is a rapid prototyping technique for the production of
three-dimensional objects through selectively sintering powder-based layer materials. The aim
of the study was to investigate the effect of energy density (ED) and formulation factors on the
printability and characteristics of SLS irbesartan tablets. The correlation between formulation factors,
ED, and printability was obtained using a decision tree model with an accuracy of 80%. FT-IR
results revealed that there was no interaction between irbesartan and the applied excipients. DSC
results indicated that irbesartan was present in an amorphous form in printed tablets. ED had a
significant influence on tablets’ physical, mechanical, and morphological characteristics. Adding
lactose monohydrate enabled faster drug release while reducing the possibility for printing with
different laser speeds. However, formulations with crospovidone were printable with a wider range
of laser speeds. The adjustment of formulation and process parameters enabled the production of SLS
tablets with hydroxypropyl methylcellulose with complete release in less than 30 min. The results
suggest that a decision tree could be a useful tool for predicting the printability of pharmaceutical
formulations. Tailoring the characteristics of SLS irbesartan tablets by ED is possible; however,
it needs to be governed by the composition of the whole formulation.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model",
volume = "13",
number = "11",
pages = "1969",
doi = "10.3390/pharmaceutics13111969"
}

Madžarević, M., Medarević, Đ., Pavlović, S., Ivković, B., Đuriš, J.,& Ibrić, S.. (2021). Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model. in Pharmaceutics
MDPI., 13(11), 1969.
https://doi.org/10.3390/pharmaceutics13111969

Madžarević M, Medarević Đ, Pavlović S, Ivković B, Đuriš J, Ibrić S. Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model. in Pharmaceutics. 2021;13(11):1969.
doi:10.3390/pharmaceutics13111969 .

Madžarević, Marijana, Medarević, Đorđe, Pavlović, Stefan, Ivković, Branka, Đuriš, Jelena, Ibrić, Svetlana, "Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model" in Pharmaceutics, 13, no. 11 (2021):1969,
https://doi.org/10.3390/pharmaceutics13111969 . .

TY  - CONF
AU  - Mudrić, Jelena
AU  - Arsenijević, Jelena
AU  - Maksimović, Zoran
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5307
AB  - Rosmarinic acid is a dominant component in the extracts of
Satureja kitaibelii (Gopčević et al., 2019). It is reported that
rosmarinic acid has antioxidant, anti-inflammatory,
antibacterial, antiviral and antimutagenic activity (Petersen
et al., 2003). The aim of this study was to develop an
optimal model by using RSM (response surface
methodology) and ANN (artificial neural network)
approach which can describe the influence of ethanol
concentration, temperature and time on the extraction of
rosmarinic acid from aerial parts of S. kitaibelii.
PB  - International Association for Pharmaceutical Technology, Mainz, Germany
C3  - 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May
T1  - Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii
SP  - 1
EP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5307
ER  - 

@conference{
author = "Mudrić, Jelena and Arsenijević, Jelena and Maksimović, Zoran and Ibrić, Svetlana and Đuriš, Jelena",
year = "2021",
abstract = "Rosmarinic acid is a dominant component in the extracts of
Satureja kitaibelii (Gopčević et al., 2019). It is reported that
rosmarinic acid has antioxidant, anti-inflammatory,
antibacterial, antiviral and antimutagenic activity (Petersen
et al., 2003). The aim of this study was to develop an
optimal model by using RSM (response surface
methodology) and ANN (artificial neural network)
approach which can describe the influence of ethanol
concentration, temperature and time on the extraction of
rosmarinic acid from aerial parts of S. kitaibelii.",
publisher = "International Association for Pharmaceutical Technology, Mainz, Germany",
journal = "12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May",
title = "Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii",
pages = "1-2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5307"
}

Mudrić, J., Arsenijević, J., Maksimović, Z., Ibrić, S.,& Đuriš, J.. (2021). Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May
International Association for Pharmaceutical Technology, Mainz, Germany., 1-2.
https://hdl.handle.net/21.15107/rcub_farfar_5307

Mudrić J, Arsenijević J, Maksimović Z, Ibrić S, Đuriš J. Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May. 2021;:1-2.
https://hdl.handle.net/21.15107/rcub_farfar_5307 .

Mudrić, Jelena, Arsenijević, Jelena, Maksimović, Zoran, Ibrić, Svetlana, Đuriš, Jelena, "Comparison of artificial neural networks and response surface methodology for efficient extraction of rosmarinic acid from Satureja kitaibelii" in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology 11-14 May (2021):1-2,
https://hdl.handle.net/21.15107/rcub_farfar_5307 .

TY  - JOUR
AU  - Milovanović, Stoja
AU  - Đuriš, Jelena
AU  - Dapčević, Aleksandra
AU  - Lučić-Škorić, Marija
AU  - Medarević, Đorđe
AU  - Pavlović, Stefan
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3782
AB  - This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
PB  - Springer Science and Business Media B.V.
T2  - Journal of Polymer Research
T1  - Preparation of floating polymer-valsartan delivery systems using supercritical CO2
VL  - 28
IS  - 3
DO  - 10.1007/s10965-021-02440-1
ER  - 

@article{
author = "Milovanović, Stoja and Đuriš, Jelena and Dapčević, Aleksandra and Lučić-Škorić, Marija and Medarević, Đorđe and Pavlović, Stefan and Ibrić, Svetlana",
year = "2021",
abstract = "This study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.",
publisher = "Springer Science and Business Media B.V.",
journal = "Journal of Polymer Research",
title = "Preparation of floating polymer-valsartan delivery systems using supercritical CO2",
volume = "28",
number = "3",
doi = "10.1007/s10965-021-02440-1"
}

Milovanović, S., Đuriš, J., Dapčević, A., Lučić-Škorić, M., Medarević, Đ., Pavlović, S.,& Ibrić, S.. (2021). Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research
Springer Science and Business Media B.V.., 28(3).
https://doi.org/10.1007/s10965-021-02440-1

Milovanović S, Đuriš J, Dapčević A, Lučić-Škorić M, Medarević Đ, Pavlović S, Ibrić S. Preparation of floating polymer-valsartan delivery systems using supercritical CO2. in Journal of Polymer Research. 2021;28(3).
doi:10.1007/s10965-021-02440-1 .

Milovanović, Stoja, Đuriš, Jelena, Dapčević, Aleksandra, Lučić-Škorić, Marija, Medarević, Đorđe, Pavlović, Stefan, Ibrić, Svetlana, "Preparation of floating polymer-valsartan delivery systems using supercritical CO2" in Journal of Polymer Research, 28, no. 3 (2021),
https://doi.org/10.1007/s10965-021-02440-1 . .

TY  - CONF
AU  - Ćirin-Varađan, Slobodanka
AU  - Đuriš, Jelena
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Aleksić, Ivana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4671
AB  - The lack of directly compressible excipients and the introduction of the high-speed
manufacturing machines have further increased the interest in the development of co-processed
excipients. In the present study, in situ fluidized bed melt granulation (FBMG) as an environmental
friendly and cost-effective method, was applied to co-process the most common filler, lactose
monohydrate, with lipid excipients glyceryl dibehenate (Compritol ® 888 ATO) or glyceryl
palmitostearate (Precirol ® ATO 5) known for their antiadhesive, lubricant and flowing aid properties
(1, 2). The goal of this study was to develop the lipid-based co-processed excipients and to investigate
their flowability and tableting properties using a solvent-free and eco-friendly, FBMG method.
The flow properties of the tested samples (the single-component excipients, their physical
mixtures, lactose (85% (w/w)) co-processed with Precirol® or Compritol ® (15% (w/w)), and
commercially available lactose-based co-processed excipients (Retalac ® and Ludipress®) were
evaluated by Carr index and Hausner ratio. Dynamic compaction analysis of the investigated excipients
was performed on a single punch instrumented tablet press (GTP D series, Gamlen Tableting Ltd, UK).
Comparable or even better flowability of co-processed excipients obtained via in situ FBMG, in
comparison to commercial co-processed excipients indicate their suitability for direct compression. Co-
processed excipients with Precirol ® and Compritol ®, as well as the corresponding physical mixtures,
showed two to almost three times lower values of total work of compression than those obtained for
commercial lactose-based excipients. Furthermore, co-processed excipients prepared with lipid
excipients showed up to 50-fold lower detachment work and up to 20-fold lower ejection work than
those obtained for Retalac ® and Ludipress®. Superior antiadhesive and lubricating properties of the
excipients prepared by in situ FBMG can be attributed to the properties of lipid excipients. Both
commercially available and the investigated co-processed excipients, prepared with lipid excipients,
showed relatively high tensile strength values (>1.7 MPa).
The results presented in this study indicate that in situ fluidized bed melt granulation can be
used as suitable co-processing technique, as a time and energy less consuming method in comparison
with commonly applied techniques such as spray drying and wet granulation. According to the results
obtained, by co-processing lactose with selected lipid excipients excellent flowability, as well as
improved tableting properties can be achieved. Novel co-processed excipients were even found to be
highly superior regarding their antiadhesive and lubricating properties in comparison to commercial
lactose-based co-processed excipients.
AB  - Nedostatak direktno kompresibilnih ekscipijenasa i uvođenje proizvodne opreme velike brzine
rada dodatno su povećali interesovanje za razvoj koprocesovanih ekscipijenasa. U ovoj studiji, in situ
granulacija topljenjem u uređaju tipa fluidizirajućeg sistema (eng. fluidized bed melt granulation,
FBMG), kao ekološki prihvatljiva i ekonomična metoda, primenjena je za koprocesovanje najčešće
korišćenog sredstva za dopunjavanje, laktoze, monohidrata, sa lipidnim ekscipijensima,
glicerildibehenatom (Compritol® 888 ATO) ili glicerilpalmitostearatom (Precirol® ATO 5), koji su
poznati po svojim antiadhezivnim, lubrikatnim i protočnim osobinama (1, 2). Cilj ovog ispitivanja je bio
razvoj novih koprocesovanih ekscipijenasa na bazi lipida primenom ekološki prihvatljive metode, koja
ne zahteva upotrebu rastvarača, i ispitivanje njihove protočnosti i tabletabilnosti.
Protočne karakteristike ispitivanih uzoraka (pojedinačni ekscipijensi, njihove fizičke smeše,
laktoza ((85% (m/m)) koprocesovana sa Precirol ®-om ili Compritol®-om (15% (m/m)), i komercijalno
dostupni koprocesovani ekscipijensi na bazi laktoze (Retalac ® i Ludipress® )) procenjene su na osnovu
vrednosti Carr-ovog indeksa i Hausner‐ovog odnosa. Laboratorijski simulator kompakcije (GTP D serija,
Gamlen Tableting Ltd, UK) korišćen je za dinamičku analizu kompakcije.
Uporedive ili čak bolje protočne karakteristike koprocesovanih ekscipijensa dobijenih metodom
in situ FBMG, u poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima, ukazuju na
njihovu podobnost za direktnu kompresiju. Koprocesovani ekscipijensi sa Precirol®-om i Compritol ®-
om, kao i odgovarajuće fizičke smeše, pokazale su dva do skoro tri puta niže vrednosti ukupnog rada
kompresije od komercijalno dostupnih ekscipijenasa na bazi laktoze. Dodatno, koprocesovani
ekscipijensi na bazi lipida pokazali su do 50 puta manji rad odvajanja i do 20 puta manji rad izbacivanja
od Retalac ®-a i Ludipress® -a. Superiorna antiadhezivna i lubrikatna svojstva koprocesovanih
ekscipijenasa pripremljenih in situ FBMG mogu se pripisati lipidnim ekscipijensima. Komercijalno
dostupni kao i ispitivani koprocesovani ekscipijensi, na bazi lipidnih ekscipijenasa, pokazali su
relativno visoke vrednosti zatezne čvrstine (> 1,7 MPa).
Predstavljeni rezultati ukazuju na to da se granulacija topljenjem u uređaju tipa fluidizirajućeg
sistema može koristiti kao pogodna metoda za koprocesovanje, koja zahteva manji utrošak energije i
vremena u poređenju sa uobičajenim tehnikama, poput sušenja raspršivanjem ili vlažne granulacije.
Dobijeni rezultati pokazuju da se koprocesovanjem laktoze sa odabranim lipidnim ekscipijensima može
postići odlična protočnost, kao i poboljšana tabletabilnost. Novi koprocesovani ekscipijensi su čak
pokazali superiornije karakteristike u pogledu svojih antiadhezivnih i lubrikatnih karakteristika u
poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima na bazi laktoze.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Application of solventless granulation method for developent of novel co‐processed excipeints
T1  - Primena metode granulacije bez upotrebe rastvarača u razvoju novih koprocesovanih ekscipijenasa
VL  - 71
IS  - 5 suplement
SP  - S80
EP  - S81
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4671
ER  - 

@conference{
author = "Ćirin-Varađan, Slobodanka and Đuriš, Jelena and Ibrić, Svetlana and Parojčić, Jelena and Aleksić, Ivana",
year = "2021",
abstract = "The lack of directly compressible excipients and the introduction of the high-speed
manufacturing machines have further increased the interest in the development of co-processed
excipients. In the present study, in situ fluidized bed melt granulation (FBMG) as an environmental
friendly and cost-effective method, was applied to co-process the most common filler, lactose
monohydrate, with lipid excipients glyceryl dibehenate (Compritol ® 888 ATO) or glyceryl
palmitostearate (Precirol ® ATO 5) known for their antiadhesive, lubricant and flowing aid properties
(1, 2). The goal of this study was to develop the lipid-based co-processed excipients and to investigate
their flowability and tableting properties using a solvent-free and eco-friendly, FBMG method.
The flow properties of the tested samples (the single-component excipients, their physical
mixtures, lactose (85% (w/w)) co-processed with Precirol® or Compritol ® (15% (w/w)), and
commercially available lactose-based co-processed excipients (Retalac ® and Ludipress®) were
evaluated by Carr index and Hausner ratio. Dynamic compaction analysis of the investigated excipients
was performed on a single punch instrumented tablet press (GTP D series, Gamlen Tableting Ltd, UK).
Comparable or even better flowability of co-processed excipients obtained via in situ FBMG, in
comparison to commercial co-processed excipients indicate their suitability for direct compression. Co-
processed excipients with Precirol ® and Compritol ®, as well as the corresponding physical mixtures,
showed two to almost three times lower values of total work of compression than those obtained for
commercial lactose-based excipients. Furthermore, co-processed excipients prepared with lipid
excipients showed up to 50-fold lower detachment work and up to 20-fold lower ejection work than
those obtained for Retalac ® and Ludipress®. Superior antiadhesive and lubricating properties of the
excipients prepared by in situ FBMG can be attributed to the properties of lipid excipients. Both
commercially available and the investigated co-processed excipients, prepared with lipid excipients,
showed relatively high tensile strength values (>1.7 MPa).
The results presented in this study indicate that in situ fluidized bed melt granulation can be
used as suitable co-processing technique, as a time and energy less consuming method in comparison
with commonly applied techniques such as spray drying and wet granulation. According to the results
obtained, by co-processing lactose with selected lipid excipients excellent flowability, as well as
improved tableting properties can be achieved. Novel co-processed excipients were even found to be
highly superior regarding their antiadhesive and lubricating properties in comparison to commercial
lactose-based co-processed excipients., Nedostatak direktno kompresibilnih ekscipijenasa i uvođenje proizvodne opreme velike brzine
rada dodatno su povećali interesovanje za razvoj koprocesovanih ekscipijenasa. U ovoj studiji, in situ
granulacija topljenjem u uređaju tipa fluidizirajućeg sistema (eng. fluidized bed melt granulation,
FBMG), kao ekološki prihvatljiva i ekonomična metoda, primenjena je za koprocesovanje najčešće
korišćenog sredstva za dopunjavanje, laktoze, monohidrata, sa lipidnim ekscipijensima,
glicerildibehenatom (Compritol® 888 ATO) ili glicerilpalmitostearatom (Precirol® ATO 5), koji su
poznati po svojim antiadhezivnim, lubrikatnim i protočnim osobinama (1, 2). Cilj ovog ispitivanja je bio
razvoj novih koprocesovanih ekscipijenasa na bazi lipida primenom ekološki prihvatljive metode, koja
ne zahteva upotrebu rastvarača, i ispitivanje njihove protočnosti i tabletabilnosti.
Protočne karakteristike ispitivanih uzoraka (pojedinačni ekscipijensi, njihove fizičke smeše,
laktoza ((85% (m/m)) koprocesovana sa Precirol ®-om ili Compritol®-om (15% (m/m)), i komercijalno
dostupni koprocesovani ekscipijensi na bazi laktoze (Retalac ® i Ludipress® )) procenjene su na osnovu
vrednosti Carr-ovog indeksa i Hausner‐ovog odnosa. Laboratorijski simulator kompakcije (GTP D serija,
Gamlen Tableting Ltd, UK) korišćen je za dinamičku analizu kompakcije.
Uporedive ili čak bolje protočne karakteristike koprocesovanih ekscipijensa dobijenih metodom
in situ FBMG, u poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima, ukazuju na
njihovu podobnost za direktnu kompresiju. Koprocesovani ekscipijensi sa Precirol®-om i Compritol ®-
om, kao i odgovarajuće fizičke smeše, pokazale su dva do skoro tri puta niže vrednosti ukupnog rada
kompresije od komercijalno dostupnih ekscipijenasa na bazi laktoze. Dodatno, koprocesovani
ekscipijensi na bazi lipida pokazali su do 50 puta manji rad odvajanja i do 20 puta manji rad izbacivanja
od Retalac ®-a i Ludipress® -a. Superiorna antiadhezivna i lubrikatna svojstva koprocesovanih
ekscipijenasa pripremljenih in situ FBMG mogu se pripisati lipidnim ekscipijensima. Komercijalno
dostupni kao i ispitivani koprocesovani ekscipijensi, na bazi lipidnih ekscipijenasa, pokazali su
relativno visoke vrednosti zatezne čvrstine (> 1,7 MPa).
Predstavljeni rezultati ukazuju na to da se granulacija topljenjem u uređaju tipa fluidizirajućeg
sistema može koristiti kao pogodna metoda za koprocesovanje, koja zahteva manji utrošak energije i
vremena u poređenju sa uobičajenim tehnikama, poput sušenja raspršivanjem ili vlažne granulacije.
Dobijeni rezultati pokazuju da se koprocesovanjem laktoze sa odabranim lipidnim ekscipijensima može
postići odlična protočnost, kao i poboljšana tabletabilnost. Novi koprocesovani ekscipijensi su čak
pokazali superiornije karakteristike u pogledu svojih antiadhezivnih i lubrikatnih karakteristika u
poređenju sa komercijalno dostupnim koprocesovanim ekscipijensima na bazi laktoze.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Application of solventless granulation method for developent of novel co‐processed excipeints, Primena metode granulacije bez upotrebe rastvarača u razvoju novih koprocesovanih ekscipijenasa",
volume = "71",
number = "5 suplement",
pages = "S80-S81",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4671"
}

Ćirin-Varađan, S., Đuriš, J., Ibrić, S., Parojčić, J.,& Aleksić, I.. (2021). Application of solventless granulation method for developent of novel co‐processed excipeints. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S80-S81.
https://hdl.handle.net/21.15107/rcub_farfar_4671

Ćirin-Varađan S, Đuriš J, Ibrić S, Parojčić J, Aleksić I. Application of solventless granulation method for developent of novel co‐processed excipeints. in Arhiv za farmaciju. 2021;71(5 suplement):S80-S81.
https://hdl.handle.net/21.15107/rcub_farfar_4671 .

Ćirin-Varađan, Slobodanka, Đuriš, Jelena, Ibrić, Svetlana, Parojčić, Jelena, Aleksić, Ivana, "Application of solventless granulation method for developent of novel co‐processed excipeints" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S80-S81,
https://hdl.handle.net/21.15107/rcub_farfar_4671 .

TY  - JOUR
AU  - Kurćubić, Ivana
AU  - Vajić, Una-Jovana
AU  - Cvijić, Sandra
AU  - Crevar-Sakač, Milkica
AU  - Bogavac-Stanojević, Nataša
AU  - Miloradović, Zoran
AU  - Mihajlović-Stanojević, Nevena
AU  - Ivanov, Milan
AU  - Karanović, Danijela
AU  - Jovović, Đurđica
AU  - Đuriš, Jelena
PY  - 2021
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3990
AB  - The objective of this study was to formulate extended-release mucoadhesive buccal tablets of propranolol hydrochloride in order to provide a prolonged absorption of propranolol hydrochloride from the buccal mucosa and to reduce presystemic metabolism and thus provide a better therapeutic effect. Besides, the aim was to perform comparative in vivo pharmacokinetic and hemodynamic studies of the developed extended-release (ER) propranolol hydrochloride 10 mg mucoadhesive buccal tablets and commercial immediate-release (IR) propranolol hydrochloride 10 mg tablets in spontaneously hypertensive rats. Formulation with 15% polyethylene oxide showed the highest degree of propranolol hydrochloride permeation, satisfactory mucoadhesiveness, and extended-release of propranolol hydrochloride, thus it was selected for further in vivo study. The pharmacokinetic study in rats showed the superiority of ER mucoadhesive buccal tablets over IR tablets in terms of propranolol hydrochloride absorption extent (AUC values: 70.32 ± 19.56 versus 31.69 ± 6.97 μg⋅h/mL), although lower maximum plasma propranolol hydrochloride concentration (Cmax) was achieved. However, no statistically significant difference was observed in Cmax between these treatments. The hemodynamic study showed that ER mucoadhesive buccal tablets provide a more pronounced decrease primarily in heart rate, but also in systolic and diastolic arterial pressure, as well as a longer heart rate reduction compared to IR tablets.
PB  - Elsevier B.V.
T2  - International Journal of Pharmaceutics
T1  - Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension
VL  - 610
DO  - 10.1016/j.ijpharm.2021.121266
ER  - 

@article{
author = "Kurćubić, Ivana and Vajić, Una-Jovana and Cvijić, Sandra and Crevar-Sakač, Milkica and Bogavac-Stanojević, Nataša and Miloradović, Zoran and Mihajlović-Stanojević, Nevena and Ivanov, Milan and Karanović, Danijela and Jovović, Đurđica and Đuriš, Jelena",
year = "2021, 2021",
abstract = "The objective of this study was to formulate extended-release mucoadhesive buccal tablets of propranolol hydrochloride in order to provide a prolonged absorption of propranolol hydrochloride from the buccal mucosa and to reduce presystemic metabolism and thus provide a better therapeutic effect. Besides, the aim was to perform comparative in vivo pharmacokinetic and hemodynamic studies of the developed extended-release (ER) propranolol hydrochloride 10 mg mucoadhesive buccal tablets and commercial immediate-release (IR) propranolol hydrochloride 10 mg tablets in spontaneously hypertensive rats. Formulation with 15% polyethylene oxide showed the highest degree of propranolol hydrochloride permeation, satisfactory mucoadhesiveness, and extended-release of propranolol hydrochloride, thus it was selected for further in vivo study. The pharmacokinetic study in rats showed the superiority of ER mucoadhesive buccal tablets over IR tablets in terms of propranolol hydrochloride absorption extent (AUC values: 70.32 ± 19.56 versus 31.69 ± 6.97 μg⋅h/mL), although lower maximum plasma propranolol hydrochloride concentration (Cmax) was achieved. However, no statistically significant difference was observed in Cmax between these treatments. The hemodynamic study showed that ER mucoadhesive buccal tablets provide a more pronounced decrease primarily in heart rate, but also in systolic and diastolic arterial pressure, as well as a longer heart rate reduction compared to IR tablets.",
publisher = "Elsevier B.V.",
journal = "International Journal of Pharmaceutics",
title = "Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension",
volume = "610",
doi = "10.1016/j.ijpharm.2021.121266"
}

Kurćubić, I., Vajić, U., Cvijić, S., Crevar-Sakač, M., Bogavac-Stanojević, N., Miloradović, Z., Mihajlović-Stanojević, N., Ivanov, M., Karanović, D., Jovović, Đ.,& Đuriš, J.. (2021). Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension. in International Journal of Pharmaceutics
Elsevier B.V.., 610.
https://doi.org/10.1016/j.ijpharm.2021.121266

Kurćubić I, Vajić U, Cvijić S, Crevar-Sakač M, Bogavac-Stanojević N, Miloradović Z, Mihajlović-Stanojević N, Ivanov M, Karanović D, Jovović Đ, Đuriš J. Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension. in International Journal of Pharmaceutics. 2021;610.
doi:10.1016/j.ijpharm.2021.121266 .

Kurćubić, Ivana, Vajić, Una-Jovana, Cvijić, Sandra, Crevar-Sakač, Milkica, Bogavac-Stanojević, Nataša, Miloradović, Zoran, Mihajlović-Stanojević, Nevena, Ivanov, Milan, Karanović, Danijela, Jovović, Đurđica, Đuriš, Jelena, "Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension" in International Journal of Pharmaceutics, 610 (2021),
https://doi.org/10.1016/j.ijpharm.2021.121266 . .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Cirin-Varađan, Slobodanka
AU  - Aleksić, Ivana
AU  - Đuriš, Mihal
AU  - Cvijić, Sandra
AU  - Ibrić, Svetlana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3905
AB  - Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.
PB  - MDPI AG
T2  - Pharmaceutics
T1  - Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients
VL  - 13
IS  - 5
DO  - 10.3390/pharmaceutics13050663
ER  - 

@article{
author = "Đuriš, Jelena and Cirin-Varađan, Slobodanka and Aleksić, Ivana and Đuriš, Mihal and Cvijić, Sandra and Ibrić, Svetlana",
year = "2021",
abstract = "Co-processing (CP) provides superior properties to excipients and has become a reliable option to facilitated formulation and manufacturing of variety of solid dosage forms. Development of directly compressible formulations with high doses of poorly flowing/compressible active pharmaceutical ingredients, such as paracetamol, remains a great challenge for the pharmaceutical industry due to the lack of understanding of the interplay between the formulation properties, process of compaction, and stages of tablets’ detachment and ejection. The aim of this study was to analyze the influence of the compression load, excipients’ co-processing and the addition of paracetamol on the obtained tablets’ tensile strength and the specific parameters of the tableting process, such as (net) compression work, elastic recovery, detachment, and ejection work, as well as the ejection force. Two types of neural networks were used to analyze the data: classification (Kohonen network) and regression networks (multilayer perceptron and radial basis function), to build prediction models and identify the variables that are predominantly affecting the tableting process and the obtained tablets’ tensile strength. It has been demonstrated that sophisticated data-mining methods are necessary to interpret complex phenomena regarding the effect of co-processing on tableting properties of directly compressible excipients.",
publisher = "MDPI AG",
journal = "Pharmaceutics",
title = "Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients",
volume = "13",
number = "5",
doi = "10.3390/pharmaceutics13050663"
}

Đuriš, J., Cirin-Varađan, S., Aleksić, I., Đuriš, M., Cvijić, S.,& Ibrić, S.. (2021). Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients. in Pharmaceutics
MDPI AG., 13(5).
https://doi.org/10.3390/pharmaceutics13050663

Đuriš J, Cirin-Varađan S, Aleksić I, Đuriš M, Cvijić S, Ibrić S. Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients. in Pharmaceutics. 2021;13(5).
doi:10.3390/pharmaceutics13050663 .

Đuriš, Jelena, Cirin-Varađan, Slobodanka, Aleksić, Ivana, Đuriš, Mihal, Cvijić, Sandra, Ibrić, Svetlana, "Application of machine-learning algorithms for better understanding of tableting properties of lactose co-processed with lipid excipients" in Pharmaceutics, 13, no. 5 (2021),
https://doi.org/10.3390/pharmaceutics13050663 . .