TY  - JOUR
AU  - Tešić, Milorad
AU  - Travica, Lazar
AU  - Giga, Vojislav
AU  - Jovanović, Ivana
AU  - Trifunović-Zamaklar, Danijela
AU  - Popović, Dejana
AU  - Mladenović, Đorđe
AU  - Radomirović, Marija
AU  - Vratonjić, Jelena
AU  - Bošković, Nikola
AU  - Dedić, Srđan
AU  - Nedeljković Arsenović, Olga
AU  - Aleksandrić, Srđan
AU  - Juričić, Stefan
AU  - Beleslin, Branko
AU  - Đorđević Dikić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5203
AB  - Background and Objectives: Mitral valve pathology and mitral regurgitation (MR) are very common in patients with hypertrophic cardiomyopathy (HCM), and the evaluation of mitral valve anatomy and degree of MR is important in patients with HCM. The aim of our study was to examine the potential influence of moderate or moderately severe MR on the prognosis, clinical presentation, and structural characteristics of HCM patients. Materials and Methods: A prospective study examined 176 patients diagnosed with primary asymmetric HCM. According to the severity of the MR, the patients were divided into two groups: Group 1 (n = 116) with no/trace or mild MR and Group 2 (n = 60) with moderate or moderately severe MR. All patients had clinical and echocardiographic examinations, as well as a 24 h Holter ECG. Results: Group 2 had significantly more often the presence of the obstructive type of HCM (p < 0.001), syncope (p = 0.030), NYHA II class (p < 0.001), and atrial fibrillation (p = 0.023). Also, Group 2 had an enlarged left atrial dimension (p < 0.001), left atrial volume index (p < 0.001), and indirectly measured systolic pressure in the right ventricle (p < 0.001). Patients with a higher grade of MR had a significantly higher E/e' (p < 0.001) and, as a result, higher values of Nt pro BNP values (p < 0.001) compared to Group 1. Kaplan-Meier analysis demonstrated that the event-free survival rate during a median follow-up of 88 (IQR 40-112) months was significantly higher in Group 1 compared to Group 2 (84% vs. 45% at 8 years; log-rank 20.4, p < 0.001). After adjustment for relevant confounders, the presence of moderate or moderately severe MR remained as an independent predictor of adverse outcomes (HR 2.788; 95% CI 1.221-6.364, p = 0.015). Conclusions: The presence of moderate or moderately severe MR was associated with unfavorable long-term outcomes in HCM patients.
PB  - MDPI
T2  - Medicina (Kaunas, Lithuania)
T1  - Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy
VL  - 59
IS  - 10
DO  - 10.3390/medicina59101798
ER  - 

@article{
author = "Tešić, Milorad and Travica, Lazar and Giga, Vojislav and Jovanović, Ivana and Trifunović-Zamaklar, Danijela and Popović, Dejana and Mladenović, Đorđe and Radomirović, Marija and Vratonjić, Jelena and Bošković, Nikola and Dedić, Srđan and Nedeljković Arsenović, Olga and Aleksandrić, Srđan and Juričić, Stefan and Beleslin, Branko and Đorđević Dikić, Ana",
year = "2023",
abstract = "Background and Objectives: Mitral valve pathology and mitral regurgitation (MR) are very common in patients with hypertrophic cardiomyopathy (HCM), and the evaluation of mitral valve anatomy and degree of MR is important in patients with HCM. The aim of our study was to examine the potential influence of moderate or moderately severe MR on the prognosis, clinical presentation, and structural characteristics of HCM patients. Materials and Methods: A prospective study examined 176 patients diagnosed with primary asymmetric HCM. According to the severity of the MR, the patients were divided into two groups: Group 1 (n = 116) with no/trace or mild MR and Group 2 (n = 60) with moderate or moderately severe MR. All patients had clinical and echocardiographic examinations, as well as a 24 h Holter ECG. Results: Group 2 had significantly more often the presence of the obstructive type of HCM (p < 0.001), syncope (p = 0.030), NYHA II class (p < 0.001), and atrial fibrillation (p = 0.023). Also, Group 2 had an enlarged left atrial dimension (p < 0.001), left atrial volume index (p < 0.001), and indirectly measured systolic pressure in the right ventricle (p < 0.001). Patients with a higher grade of MR had a significantly higher E/e' (p < 0.001) and, as a result, higher values of Nt pro BNP values (p < 0.001) compared to Group 1. Kaplan-Meier analysis demonstrated that the event-free survival rate during a median follow-up of 88 (IQR 40-112) months was significantly higher in Group 1 compared to Group 2 (84% vs. 45% at 8 years; log-rank 20.4, p < 0.001). After adjustment for relevant confounders, the presence of moderate or moderately severe MR remained as an independent predictor of adverse outcomes (HR 2.788; 95% CI 1.221-6.364, p = 0.015). Conclusions: The presence of moderate or moderately severe MR was associated with unfavorable long-term outcomes in HCM patients.",
publisher = "MDPI",
journal = "Medicina (Kaunas, Lithuania)",
title = "Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy",
volume = "59",
number = "10",
doi = "10.3390/medicina59101798"
}

Tešić, M., Travica, L., Giga, V., Jovanović, I., Trifunović-Zamaklar, D., Popović, D., Mladenović, Đ., Radomirović, M., Vratonjić, J., Bošković, N., Dedić, S., Nedeljković Arsenović, O., Aleksandrić, S., Juričić, S., Beleslin, B.,& Đorđević Dikić, A.. (2023). Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy. in Medicina (Kaunas, Lithuania)
MDPI., 59(10).
https://doi.org/10.3390/medicina59101798

Tešić M, Travica L, Giga V, Jovanović I, Trifunović-Zamaklar D, Popović D, Mladenović Đ, Radomirović M, Vratonjić J, Bošković N, Dedić S, Nedeljković Arsenović O, Aleksandrić S, Juričić S, Beleslin B, Đorđević Dikić A. Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy. in Medicina (Kaunas, Lithuania). 2023;59(10).
doi:10.3390/medicina59101798 .

Tešić, Milorad, Travica, Lazar, Giga, Vojislav, Jovanović, Ivana, Trifunović-Zamaklar, Danijela, Popović, Dejana, Mladenović, Đorđe, Radomirović, Marija, Vratonjić, Jelena, Bošković, Nikola, Dedić, Srđan, Nedeljković Arsenović, Olga, Aleksandrić, Srđan, Juričić, Stefan, Beleslin, Branko, Đorđević Dikić, Ana, "Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy" in Medicina (Kaunas, Lithuania), 59, no. 10 (2023),
https://doi.org/10.3390/medicina59101798 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Lavie, Carl
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4653
AB  - The assuredness that adverse life stressors can lead to major negative impacts on an individual's health has been held since antiquity. Stress is considered a state of homeostasis being challenged, with biological consequences that can cause cardiovascular diseases (CVD). Stressors may be diverse and include a variety of psychological stressors, such as family stress, job strain, effort-award imbalance, long working hours, insecurity, social isolation, and lack of purpose in life. However, stressors may also be physical, immunological, metabolic, or environmental. Type of personality, anxiety, depression, pessimism or hostility, previous experience, genomics, body composition, nutritive and training status modulate stress responses and are important co-stressors. Chronic stress is linked with altered neurohormonal activity, which increases apoptotic pathways in cardiomyocytes. These pathways contribute to impaired myocardial contractility, increased risk of myocardial ischemia, infarction, heart failure, and arrhythmias. While stress is a vital risk factor for CVD, it has not been a major focus of preventive strategies. The purpose of this article is to review the impact of stress on CVD risk with an emphasis on approaches for stress reduction. Strength and endurance exercise, although being stress itself, leads to better adaptiveness to other types of stress, and by far has played an inevitable role in CVD risk reduction. Innovative strategies to combat CVD are strongly needed and exercise may be the best population-level cost-effective approach.
PB  - Wolters Kluwer Medknow Publications
T2  - Heart and Mind
T1  - Stress, cardiovascular diseases and exercise - A narrative review
VL  - 7
IS  - 1
SP  - 18
EP  - 24
DO  - 10.4103/hm.hm_33_22
ER  - 

@article{
author = "Popović, Dejana and Lavie, Carl",
year = "2023",
abstract = "The assuredness that adverse life stressors can lead to major negative impacts on an individual's health has been held since antiquity. Stress is considered a state of homeostasis being challenged, with biological consequences that can cause cardiovascular diseases (CVD). Stressors may be diverse and include a variety of psychological stressors, such as family stress, job strain, effort-award imbalance, long working hours, insecurity, social isolation, and lack of purpose in life. However, stressors may also be physical, immunological, metabolic, or environmental. Type of personality, anxiety, depression, pessimism or hostility, previous experience, genomics, body composition, nutritive and training status modulate stress responses and are important co-stressors. Chronic stress is linked with altered neurohormonal activity, which increases apoptotic pathways in cardiomyocytes. These pathways contribute to impaired myocardial contractility, increased risk of myocardial ischemia, infarction, heart failure, and arrhythmias. While stress is a vital risk factor for CVD, it has not been a major focus of preventive strategies. The purpose of this article is to review the impact of stress on CVD risk with an emphasis on approaches for stress reduction. Strength and endurance exercise, although being stress itself, leads to better adaptiveness to other types of stress, and by far has played an inevitable role in CVD risk reduction. Innovative strategies to combat CVD are strongly needed and exercise may be the best population-level cost-effective approach.",
publisher = "Wolters Kluwer Medknow Publications",
journal = "Heart and Mind",
title = "Stress, cardiovascular diseases and exercise - A narrative review",
volume = "7",
number = "1",
pages = "18-24",
doi = "10.4103/hm.hm_33_22"
}

Popović, D.,& Lavie, C.. (2023). Stress, cardiovascular diseases and exercise - A narrative review. in Heart and Mind
Wolters Kluwer Medknow Publications., 7(1), 18-24.
https://doi.org/10.4103/hm.hm_33_22

Popović D, Lavie C. Stress, cardiovascular diseases and exercise - A narrative review. in Heart and Mind. 2023;7(1):18-24.
doi:10.4103/hm.hm_33_22 .

Popović, Dejana, Lavie, Carl, "Stress, cardiovascular diseases and exercise - A narrative review" in Heart and Mind, 7, no. 1 (2023):18-24,
https://doi.org/10.4103/hm.hm_33_22 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Bjelobrk, Marija
AU  - Tesić, Milorad
AU  - Seman, Stefan
AU  - Jayasinghe, Sisitha
AU  - Hills, Andrew
AU  - Samuel Babu, Abraham
AU  - Jakovljević, Đorđe.
AU  - Stoner, Lee
AU  - Ozemek, Cemal
AU  - Bond, Samantha
AU  - Faghy, Mark
AU  - Pronk, Nicolaas
AU  - Lavie, Carl
AU  - Arena, Ross
AU  - On behalf of the HL - PIVOT Network
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4064
AB  - Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.
PB  - W.B. Saunders
T2  - Progress in Cardiovascular Diseases
T1  - Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise
DO  - 10.1016/j.pcad.2022.01.008
ER  - 

@article{
author = "Popović, Dejana and Bjelobrk, Marija and Tesić, Milorad and Seman, Stefan and Jayasinghe, Sisitha and Hills, Andrew and Samuel Babu, Abraham and Jakovljević, Đorđe. and Stoner, Lee and Ozemek, Cemal and Bond, Samantha and Faghy, Mark and Pronk, Nicolaas and Lavie, Carl and Arena, Ross and On behalf of the HL - PIVOT Network",
year = "2022",
abstract = "Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.",
publisher = "W.B. Saunders",
journal = "Progress in Cardiovascular Diseases",
title = "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise",
doi = "10.1016/j.pcad.2022.01.008"
}

Popović, D., Bjelobrk, M., Tesić, M., Seman, S., Jayasinghe, S., Hills, A., Samuel Babu, A., Jakovljević, Đorđe., Stoner, L., Ozemek, C., Bond, S., Faghy, M., Pronk, N., Lavie, C., Arena, R.,& On behalf of the HL - PIVOT Network. (2022). Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases
W.B. Saunders..
https://doi.org/10.1016/j.pcad.2022.01.008

Popović D, Bjelobrk M, Tesić M, Seman S, Jayasinghe S, Hills A, Samuel Babu A, Jakovljević Đ, Stoner L, Ozemek C, Bond S, Faghy M, Pronk N, Lavie C, Arena R, On behalf of the HL - PIVOT Network. Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases. 2022;.
doi:10.1016/j.pcad.2022.01.008 .

Popović, Dejana, Bjelobrk, Marija, Tesić, Milorad, Seman, Stefan, Jayasinghe, Sisitha, Hills, Andrew, Samuel Babu, Abraham, Jakovljević, Đorđe., Stoner, Lee, Ozemek, Cemal, Bond, Samantha, Faghy, Mark, Pronk, Nicolaas, Lavie, Carl, Arena, Ross, On behalf of the HL - PIVOT Network, "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise" in Progress in Cardiovascular Diseases (2022),
https://doi.org/10.1016/j.pcad.2022.01.008 . .

TY  - JOUR
AU  - Taylor, Jenna
AU  - Popović, Dejana
AU  - Lavie, Carl
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4251
PB  - Elsevier Inc.
T2  - Canadian Journal of CardiologyOpen Access
T1  - Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?
VL  - 38
IS  - 8
SP  - 1135
EP  - 1137
DO  - 10.1016/j.cjca.2022.03.020
ER  - 

@article{
author = "Taylor, Jenna and Popović, Dejana and Lavie, Carl",
year = "2022",
publisher = "Elsevier Inc.",
journal = "Canadian Journal of CardiologyOpen Access",
title = "Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?",
volume = "38",
number = "8",
pages = "1135-1137",
doi = "10.1016/j.cjca.2022.03.020"
}

Taylor, J., Popović, D.,& Lavie, C.. (2022). Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?. in Canadian Journal of CardiologyOpen Access
Elsevier Inc.., 38(8), 1135-1137.
https://doi.org/10.1016/j.cjca.2022.03.020

Taylor J, Popović D, Lavie C. Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?. in Canadian Journal of CardiologyOpen Access. 2022;38(8):1135-1137.
doi:10.1016/j.cjca.2022.03.020 .

Taylor, Jenna, Popović, Dejana, Lavie, Carl, "Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?" in Canadian Journal of CardiologyOpen Access, 38, no. 8 (2022):1135-1137,
https://doi.org/10.1016/j.cjca.2022.03.020 . .

TY  - JOUR
AU  - Smole, Tim
AU  - Žunkovič, Bojan
AU  - Pičulin, Matej
AU  - Kokalj, Enja
AU  - Robnik-Šikonja, Marko
AU  - Kukar, Matjaž
AU  - Fotiadis, Dimitrios I.
AU  - Pezoulas, Vasileios C.
AU  - Tachos, Nikolaos S.
AU  - Barlocco, Fausto
AU  - Mazzarotto, Francesco
AU  - Popović, Dejana
AU  - Maier, Lars
AU  - Velicki, Lazar
AU  - MacGowan, Guy A.
AU  - Olivotto, Iacopo
AU  - Filipović, Nenad
AU  - Jakovljević, Đorđe G.
AU  - Bosnić, Zoran
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3928
AB  - Background: Machine learning (ML) and artificial intelligence are emerging as important components of precision medicine that enhance diagnosis and risk stratification. Risk stratification tools for hypertrophic cardiomyopathy (HCM) exist, but they are based on traditional statistical methods. The aim was to develop a novel machine learning risk stratification tool for the prediction of 5-year risk in HCM. The goal was to determine if its predictive accuracy is higher than the accuracy of the state-of-the-art tools. Method: Data from a total of 2302 patients were used. The data were comprised of demographic characteristics, genetic data, clinical investigations, medications, and disease-related events. Four classification models were applied to model the risk level, and their decisions were explained using the SHAP (SHapley Additive exPlanations) method. Unwanted cardiac events were defined as sustained ventricular tachycardia occurrence (VT), heart failure (HF), ICD activation, sudden cardiac death (SCD), cardiac death, and all-cause death. Results: The proposed machine learning approach outperformed the similar existing risk-stratification models for SCD, cardiac death, and all-cause death risk-stratification: it achieved higher AUC by 17%, 9%, and 1%, respectively. The boosted trees achieved the best performing AUC of 0.82. The resulting model most accurately predicts VT, HF, and ICD with AUCs of 0.90, 0.88, and 0.87, respectively. Conclusions: The proposed risk-stratification model demonstrates high accuracy in predicting events in patients with hypertrophic cardiomyopathy. The use of a machine-learning risk stratification model may improve patient management, clinical practice, and outcomes in general.
PB  - Elsevier Ltd
T2  - Computers in Biology and Medicine
T1  - A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy
VL  - 135
DO  - 10.1016/j.compbiomed.2021.104648
ER  - 

@article{
author = "Smole, Tim and Žunkovič, Bojan and Pičulin, Matej and Kokalj, Enja and Robnik-Šikonja, Marko and Kukar, Matjaž and Fotiadis, Dimitrios I. and Pezoulas, Vasileios C. and Tachos, Nikolaos S. and Barlocco, Fausto and Mazzarotto, Francesco and Popović, Dejana and Maier, Lars and Velicki, Lazar and MacGowan, Guy A. and Olivotto, Iacopo and Filipović, Nenad and Jakovljević, Đorđe G. and Bosnić, Zoran",
year = "2021",
abstract = "Background: Machine learning (ML) and artificial intelligence are emerging as important components of precision medicine that enhance diagnosis and risk stratification. Risk stratification tools for hypertrophic cardiomyopathy (HCM) exist, but they are based on traditional statistical methods. The aim was to develop a novel machine learning risk stratification tool for the prediction of 5-year risk in HCM. The goal was to determine if its predictive accuracy is higher than the accuracy of the state-of-the-art tools. Method: Data from a total of 2302 patients were used. The data were comprised of demographic characteristics, genetic data, clinical investigations, medications, and disease-related events. Four classification models were applied to model the risk level, and their decisions were explained using the SHAP (SHapley Additive exPlanations) method. Unwanted cardiac events were defined as sustained ventricular tachycardia occurrence (VT), heart failure (HF), ICD activation, sudden cardiac death (SCD), cardiac death, and all-cause death. Results: The proposed machine learning approach outperformed the similar existing risk-stratification models for SCD, cardiac death, and all-cause death risk-stratification: it achieved higher AUC by 17%, 9%, and 1%, respectively. The boosted trees achieved the best performing AUC of 0.82. The resulting model most accurately predicts VT, HF, and ICD with AUCs of 0.90, 0.88, and 0.87, respectively. Conclusions: The proposed risk-stratification model demonstrates high accuracy in predicting events in patients with hypertrophic cardiomyopathy. The use of a machine-learning risk stratification model may improve patient management, clinical practice, and outcomes in general.",
publisher = "Elsevier Ltd",
journal = "Computers in Biology and Medicine",
title = "A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy",
volume = "135",
doi = "10.1016/j.compbiomed.2021.104648"
}

Smole, T., Žunkovič, B., Pičulin, M., Kokalj, E., Robnik-Šikonja, M., Kukar, M., Fotiadis, D. I., Pezoulas, V. C., Tachos, N. S., Barlocco, F., Mazzarotto, F., Popović, D., Maier, L., Velicki, L., MacGowan, G. A., Olivotto, I., Filipović, N., Jakovljević, Đ. G.,& Bosnić, Z.. (2021). A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy. in Computers in Biology and Medicine
Elsevier Ltd., 135.
https://doi.org/10.1016/j.compbiomed.2021.104648

Smole T, Žunkovič B, Pičulin M, Kokalj E, Robnik-Šikonja M, Kukar M, Fotiadis DI, Pezoulas VC, Tachos NS, Barlocco F, Mazzarotto F, Popović D, Maier L, Velicki L, MacGowan GA, Olivotto I, Filipović N, Jakovljević ĐG, Bosnić Z. A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy. in Computers in Biology and Medicine. 2021;135.
doi:10.1016/j.compbiomed.2021.104648 .

Smole, Tim, Žunkovič, Bojan, Pičulin, Matej, Kokalj, Enja, Robnik-Šikonja, Marko, Kukar, Matjaž, Fotiadis, Dimitrios I., Pezoulas, Vasileios C., Tachos, Nikolaos S., Barlocco, Fausto, Mazzarotto, Francesco, Popović, Dejana, Maier, Lars, Velicki, Lazar, MacGowan, Guy A., Olivotto, Iacopo, Filipović, Nenad, Jakovljević, Đorđe G., Bosnić, Zoran, "A machine learning-based risk stratification model for ventricular tachycardia and heart failure in hypertrophic cardiomyopathy" in Computers in Biology and Medicine, 135 (2021),
https://doi.org/10.1016/j.compbiomed.2021.104648 . .

TY  - JOUR
AU  - Vidojević, Dejana
AU  - Seman, Stefan
AU  - Lasica, Ratko
AU  - Tešić, Milorad
AU  - Sarić-Matutinović, Marija
AU  - Jovičić, Snežana
AU  - Ignjatović, Svetlana
AU  - Arena, Ross
AU  - Damjanović, Svetozar
AU  - Popović, Dejana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3779
AB  - Purpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Hormones
T1  - Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease
VL  - 20
SP  - 381
EP  - 387
DO  - 10.1007/s42000-020-00270-2
ER  - 

@article{
author = "Vidojević, Dejana and Seman, Stefan and Lasica, Ratko and Tešić, Milorad and Sarić-Matutinović, Marija and Jovičić, Snežana and Ignjatović, Svetlana and Arena, Ross and Damjanović, Svetozar and Popović, Dejana",
year = "2021",
abstract = "Purpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Hormones",
title = "Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease",
volume = "20",
pages = "381-387",
doi = "10.1007/s42000-020-00270-2"
}

Vidojević, D., Seman, S., Lasica, R., Tešić, M., Sarić-Matutinović, M., Jovičić, S., Ignjatović, S., Arena, R., Damjanović, S.,& Popović, D.. (2021). Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease. in Hormones
Springer Science and Business Media Deutschland GmbH., 20, 381-387.
https://doi.org/10.1007/s42000-020-00270-2

Vidojević D, Seman S, Lasica R, Tešić M, Sarić-Matutinović M, Jovičić S, Ignjatović S, Arena R, Damjanović S, Popović D. Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease. in Hormones. 2021;20:381-387.
doi:10.1007/s42000-020-00270-2 .

Vidojević, Dejana, Seman, Stefan, Lasica, Ratko, Tešić, Milorad, Sarić-Matutinović, Marija, Jovičić, Snežana, Ignjatović, Svetlana, Arena, Ross, Damjanović, Svetozar, Popović, Dejana, "Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease" in Hormones, 20 (2021):381-387,
https://doi.org/10.1007/s42000-020-00270-2 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Damjanović, Svetozar
AU  - Popović, Bojana
AU  - Kocijančić, Aleksandar
AU  - Labudović, Dragana
AU  - Seman, Stefan
AU  - Stojiljković, Stanimir
AU  - Tesić, Milorad
AU  - Arena, Ross
AU  - Lasica, Ratko
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4020
AB  - Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary parameters and stress hormones during anticipation of stress in different chronic stress adaptive models is needed. As an addition to our previous research, a total of 57 subjects (16 elite male wrestlers, 21 water polo player and 20 sedentary subjects matched for age) were analyzed. Cardiopulmonary exercise testing (CPET) on a treadmill was used as the laboratory stress model; peak oxygen consumption (VO2) was obtained during CPET. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte stimulating hormone (alpha-MSH) and N-terminal-pro-B type natriuretic peptide (NT-pro-BNP) were measured by radioimmunometric, radioimmunoassay and immunoassay sandwich technique, respectively, together with cardiopulmonary measurements, 10 minutes pre-CPET and at the initiation of CPET. The response of diastolic blood pressure and heart rate was different between groups during stress anticipation (p¼0.019, 0.049, respectively), while systolic blood pressure, peak VO2 and carbon-dioxide production responses were similar. ACTH and cortisol increased during the experimental condition, NT-pro-BNP decreased and alpha-MSH remained unchanged. All groups had similar hormonal responses during stress anticipation with the exception of the ACTH/cortisol ratio. In all three groups, DNT-pro-BNP during stress anticipation was the best independent predictor of peak VO2 (B¼36.01, r¼0.37, p¼0.001). In conclusion, the type of chronic stress exposure influences the hemodynamic response during anticipation of physical stress and the path of hormonal stress axis activation. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. LAY SUMMARY The study revealed differences in hormonal and hemodynamic responses during anticipation of stress between athletes and sedentary participants. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. Abbreviations: ACTH: adrenocorticitropic hormone; BSA: body surface area; BW: body weight; C: controls; CPET: cardiopulmonary exercise test; DBP: diastolic arterial blood pressure; FFM: fat-free mass; FM: fat mass; HR: heart rate; MSH: melanocyte-stimulating hormone; NT-pro-BNP: N terminal-pro-B type natriuretic peptide; SBP: systolic arterial blood pressure; VCO2: carbon dioxide production; VE: minute ventilation; VO2: oxygen consumption; W: wrestlers; WP: water polo players
PB  - Taylor and Francis Ltd.
T2  - Stress
T1  - Physiological behavior during stress anticipation across different chronic stress exposure adaptive models
DO  - 10.1080/10253890.2021.2006178
ER  - 

@article{
author = "Popović, Dejana and Damjanović, Svetozar and Popović, Bojana and Kocijančić, Aleksandar and Labudović, Dragana and Seman, Stefan and Stojiljković, Stanimir and Tesić, Milorad and Arena, Ross and Lasica, Ratko",
year = "2021",
abstract = "Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary parameters and stress hormones during anticipation of stress in different chronic stress adaptive models is needed. As an addition to our previous research, a total of 57 subjects (16 elite male wrestlers, 21 water polo player and 20 sedentary subjects matched for age) were analyzed. Cardiopulmonary exercise testing (CPET) on a treadmill was used as the laboratory stress model; peak oxygen consumption (VO2) was obtained during CPET. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte stimulating hormone (alpha-MSH) and N-terminal-pro-B type natriuretic peptide (NT-pro-BNP) were measured by radioimmunometric, radioimmunoassay and immunoassay sandwich technique, respectively, together with cardiopulmonary measurements, 10 minutes pre-CPET and at the initiation of CPET. The response of diastolic blood pressure and heart rate was different between groups during stress anticipation (p¼0.019, 0.049, respectively), while systolic blood pressure, peak VO2 and carbon-dioxide production responses were similar. ACTH and cortisol increased during the experimental condition, NT-pro-BNP decreased and alpha-MSH remained unchanged. All groups had similar hormonal responses during stress anticipation with the exception of the ACTH/cortisol ratio. In all three groups, DNT-pro-BNP during stress anticipation was the best independent predictor of peak VO2 (B¼36.01, r¼0.37, p¼0.001). In conclusion, the type of chronic stress exposure influences the hemodynamic response during anticipation of physical stress and the path of hormonal stress axis activation. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. LAY SUMMARY The study revealed differences in hormonal and hemodynamic responses during anticipation of stress between athletes and sedentary participants. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. Abbreviations: ACTH: adrenocorticitropic hormone; BSA: body surface area; BW: body weight; C: controls; CPET: cardiopulmonary exercise test; DBP: diastolic arterial blood pressure; FFM: fat-free mass; FM: fat mass; HR: heart rate; MSH: melanocyte-stimulating hormone; NT-pro-BNP: N terminal-pro-B type natriuretic peptide; SBP: systolic arterial blood pressure; VCO2: carbon dioxide production; VE: minute ventilation; VO2: oxygen consumption; W: wrestlers; WP: water polo players",
publisher = "Taylor and Francis Ltd.",
journal = "Stress",
title = "Physiological behavior during stress anticipation across different chronic stress exposure adaptive models",
doi = "10.1080/10253890.2021.2006178"
}

Popović, D., Damjanović, S., Popović, B., Kocijančić, A., Labudović, D., Seman, S., Stojiljković, S., Tesić, M., Arena, R.,& Lasica, R.. (2021). Physiological behavior during stress anticipation across different chronic stress exposure adaptive models. in Stress
Taylor and Francis Ltd...
https://doi.org/10.1080/10253890.2021.2006178

Popović D, Damjanović S, Popović B, Kocijančić A, Labudović D, Seman S, Stojiljković S, Tesić M, Arena R, Lasica R. Physiological behavior during stress anticipation across different chronic stress exposure adaptive models. in Stress. 2021;.
doi:10.1080/10253890.2021.2006178 .

Popović, Dejana, Damjanović, Svetozar, Popović, Bojana, Kocijančić, Aleksandar, Labudović, Dragana, Seman, Stefan, Stojiljković, Stanimir, Tesić, Milorad, Arena, Ross, Lasica, Ratko, "Physiological behavior during stress anticipation across different chronic stress exposure adaptive models" in Stress (2021),
https://doi.org/10.1080/10253890.2021.2006178 . .

TY  - JOUR
AU  - Kojić, Filip
AU  - Ranisavljev, Igor
AU  - Ćosić, Dušan
AU  - Popović, Dejana
AU  - Stojiljković, Stanimir
AU  - Ilić, Vladimir
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3945
AB  - The aim of the study was to compare the effects of two different training protocols, which differ in the duration of the eccentric phase, on the one-repetition maximum (1RM), thickness and contractile properties of elbow flexors. Twenty untrained college students were randomly divided into two experimental groups, based on the training tempo: FEG (Faster Eccentric Group: 1/0/1/0) and SEG (Slower Eccentric Group: 4/0/1/0). Training intervention was a biceps bending exercise, conducted twice a week for 7 weeks. The intensity (60–70% RM), sets (3–4) and rest intervals (120 s) were held constant, while repetitions were performed until it was not possible to maintain a set duration. In the initial and final measurements, 1RM, muscle thickness and tensiomyography parameters – contraction time (Tc) and radial deformation (Dm) – were evaluated. An ANCOVA model (using baseline outcomes as covariates) was applied to determine between-group differences at post-test, while Pearson’s product-moment correlation coefficient was used to investigate the relationship between absolute changes in muscle thickness and Dm. Muscle strength increase was greater for SEG than for FEG (6.0 ± 1.76 vs. 3.30 ± 2.26 kg, p < 0.01). In both groups muscle thickness increased equally (FEG: 3.24 ± 2.01 vs. SEG: 3.57 ± 1.17 mm, p < 0.01), while an overall reduction in Dm was observed (FEG: 1.99 ± 1.20 vs. SEG: 2.26 ± 1.03 mm, p < 0.01). Values of Tc remained unchanged. A significant negative relationship was observed between changes in muscle thickness and Dm (r = -0.763, Adj.R² = 0.560, p < 0.01). These results indicate that the duration of the eccentric phase has no effect on muscle hypertrophy in untrained subjects, but that slower eccentric movement significantly increases 1RM.
PB  - Institute of Sport
T2  - Biology of Sport
T1  - Effects of resistance training on hypertrophy, strength and tensiomyography parameters of elbow flexors: Role of eccentric phase duration
VL  - 38
IS  - 4
SP  - 587
EP  - 594
DO  - 10.5114/biolsport.2021.99323
ER  - 

@article{
author = "Kojić, Filip and Ranisavljev, Igor and Ćosić, Dušan and Popović, Dejana and Stojiljković, Stanimir and Ilić, Vladimir",
year = "2021",
abstract = "The aim of the study was to compare the effects of two different training protocols, which differ in the duration of the eccentric phase, on the one-repetition maximum (1RM), thickness and contractile properties of elbow flexors. Twenty untrained college students were randomly divided into two experimental groups, based on the training tempo: FEG (Faster Eccentric Group: 1/0/1/0) and SEG (Slower Eccentric Group: 4/0/1/0). Training intervention was a biceps bending exercise, conducted twice a week for 7 weeks. The intensity (60–70% RM), sets (3–4) and rest intervals (120 s) were held constant, while repetitions were performed until it was not possible to maintain a set duration. In the initial and final measurements, 1RM, muscle thickness and tensiomyography parameters – contraction time (Tc) and radial deformation (Dm) – were evaluated. An ANCOVA model (using baseline outcomes as covariates) was applied to determine between-group differences at post-test, while Pearson’s product-moment correlation coefficient was used to investigate the relationship between absolute changes in muscle thickness and Dm. Muscle strength increase was greater for SEG than for FEG (6.0 ± 1.76 vs. 3.30 ± 2.26 kg, p < 0.01). In both groups muscle thickness increased equally (FEG: 3.24 ± 2.01 vs. SEG: 3.57 ± 1.17 mm, p < 0.01), while an overall reduction in Dm was observed (FEG: 1.99 ± 1.20 vs. SEG: 2.26 ± 1.03 mm, p < 0.01). Values of Tc remained unchanged. A significant negative relationship was observed between changes in muscle thickness and Dm (r = -0.763, Adj.R² = 0.560, p < 0.01). These results indicate that the duration of the eccentric phase has no effect on muscle hypertrophy in untrained subjects, but that slower eccentric movement significantly increases 1RM.",
publisher = "Institute of Sport",
journal = "Biology of Sport",
title = "Effects of resistance training on hypertrophy, strength and tensiomyography parameters of elbow flexors: Role of eccentric phase duration",
volume = "38",
number = "4",
pages = "587-594",
doi = "10.5114/biolsport.2021.99323"
}

Kojić, F., Ranisavljev, I., Ćosić, D., Popović, D., Stojiljković, S.,& Ilić, V.. (2021). Effects of resistance training on hypertrophy, strength and tensiomyography parameters of elbow flexors: Role of eccentric phase duration. in Biology of Sport
Institute of Sport., 38(4), 587-594.
https://doi.org/10.5114/biolsport.2021.99323

Kojić F, Ranisavljev I, Ćosić D, Popović D, Stojiljković S, Ilić V. Effects of resistance training on hypertrophy, strength and tensiomyography parameters of elbow flexors: Role of eccentric phase duration. in Biology of Sport. 2021;38(4):587-594.
doi:10.5114/biolsport.2021.99323 .

Kojić, Filip, Ranisavljev, Igor, Ćosić, Dušan, Popović, Dejana, Stojiljković, Stanimir, Ilić, Vladimir, "Effects of resistance training on hypertrophy, strength and tensiomyography parameters of elbow flexors: Role of eccentric phase duration" in Biology of Sport, 38, no. 4 (2021):587-594,
https://doi.org/10.5114/biolsport.2021.99323 . .

TY  - JOUR
AU  - Bjelobrk, Marija
AU  - Lakočević, Milan
AU  - Damjanović, Svetozar
AU  - Petakov, Milan
AU  - Petrović, Milan
AU  - Bosnić, Zoran
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3930
AB  - Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1. Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32.6 ± 13.1 vs. C: 36.2 ± 10.6, p >.05) before the initiation of treatment. Standard echocardiography at rest was used to assess left ventricular ejection fraction (LVEF) and pulmonary artery systolic pressure (PASP). Cardiopulmonary exercise testing (CPET) was performed on a recumbent ergometer using a ramp protocol. Results: LVEF was similar in both groups (GD-S: 65.1 ± 5.2% vs. C: 65.2 ± 5.2%, p >.05), as well as PAPS (24.1 ± 4.2 mmHg vs. C: 25.5 ± 1.3 mmHg, p >.05). GD-S had lower weight (p <.05) and worse CPET responses compared to C, including peak values of heart rate, oxygen consumption, carbondioxide production (VCO2), end-tidal pressure of CO2, and O2 pulse, as well as HR reserve after 3 min of recovery and the minute ventilation/VCO2 slope. Conclusions: Patients with GD type I have an abnormal CPET response compared to healthy controls likely due to the complex pathophysiologic process in GD that impacts multiple systems integral to the physiologic response to exercise.
PB  - John Wiley and Sons Inc
T2  - Molecular Genetics and Genomic Medicine
T1  - Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I
VL  - 9
IS  - 8
DO  - 10.1002/mgg3.1757
ER  - 

@article{
author = "Bjelobrk, Marija and Lakočević, Milan and Damjanović, Svetozar and Petakov, Milan and Petrović, Milan and Bosnić, Zoran and Arena, Ross and Popović, Dejana",
year = "2021",
abstract = "Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1. Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32.6 ± 13.1 vs. C: 36.2 ± 10.6, p >.05) before the initiation of treatment. Standard echocardiography at rest was used to assess left ventricular ejection fraction (LVEF) and pulmonary artery systolic pressure (PASP). Cardiopulmonary exercise testing (CPET) was performed on a recumbent ergometer using a ramp protocol. Results: LVEF was similar in both groups (GD-S: 65.1 ± 5.2% vs. C: 65.2 ± 5.2%, p >.05), as well as PAPS (24.1 ± 4.2 mmHg vs. C: 25.5 ± 1.3 mmHg, p >.05). GD-S had lower weight (p <.05) and worse CPET responses compared to C, including peak values of heart rate, oxygen consumption, carbondioxide production (VCO2), end-tidal pressure of CO2, and O2 pulse, as well as HR reserve after 3 min of recovery and the minute ventilation/VCO2 slope. Conclusions: Patients with GD type I have an abnormal CPET response compared to healthy controls likely due to the complex pathophysiologic process in GD that impacts multiple systems integral to the physiologic response to exercise.",
publisher = "John Wiley and Sons Inc",
journal = "Molecular Genetics and Genomic Medicine",
title = "Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I",
volume = "9",
number = "8",
doi = "10.1002/mgg3.1757"
}

Bjelobrk, M., Lakočević, M., Damjanović, S., Petakov, M., Petrović, M., Bosnić, Z., Arena, R.,& Popović, D.. (2021). Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I. in Molecular Genetics and Genomic Medicine
John Wiley and Sons Inc., 9(8).
https://doi.org/10.1002/mgg3.1757

Bjelobrk M, Lakočević M, Damjanović S, Petakov M, Petrović M, Bosnić Z, Arena R, Popović D. Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I. in Molecular Genetics and Genomic Medicine. 2021;9(8).
doi:10.1002/mgg3.1757 .

Bjelobrk, Marija, Lakočević, Milan, Damjanović, Svetozar, Petakov, Milan, Petrović, Milan, Bosnić, Zoran, Arena, Ross, Popović, Dejana, "Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I" in Molecular Genetics and Genomic Medicine, 9, no. 8 (2021),
https://doi.org/10.1002/mgg3.1757 . .

TY  - JOUR
AU  - Pandhita, Bashar A.W.
AU  - Okwose, Nduka C.
AU  - Koshy, Aaron
AU  - Fernández, Óscar G.
AU  - Cruz, Noelia B.
AU  - Eggett, Christopher
AU  - Velicki, Lazar
AU  - Popović, Dejana
AU  - MacGowan, Guy A.
AU  - Jakovljević, Đorđe G.
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3923
AB  - Objectives: The aim of the present study was to assess the validity and trending ability of the bioreactance method in estimating cardiac output at rest and in response to stress in advanced heart failure patients and heart transplant candidates. Design: This was a prospective single-center study. Setting: This study was conducted at the heart transplant center at the Freeman Hospital, Newcastle upon Tyne, UK. Participants: Eighteen patients with advanced chronic heart failure due to reduced left ventricular ejection fraction (19 ± 7%), and peak oxygen consumption 12.3 ± 3.9 mL/kg/min. Interventions: Participants underwent right heart catheterization using the Swan-Ganz catheter. Measurements and Main Results: Cardiac output was measured simultaneously using thermodilution and bioreactance at rest and during active straight leg raise test to volitional exertion. There was no significant difference in cardiac index values obtained by the thermodilution and bioreactance methods (2.26 ± 0.59 v 2.38 ± 0.50 L/min, p > 0.05) at rest and peak straight leg raise test (2.92 ± 0.77 v 3.01 ± 0.66 L/min, p > 0.05). In response to active leg raise test, thermodilution cardiac output increased by 22% and bioreactance by 21%. There was also a strong relationship between cardiac outputs from both methods at rest (r = 0.88, p < 0.01) and peak straight leg raise test (r = 0.92, p < 0.01). Cartesian plot analysis showed good trending ability of bioreactance compared with thermodilution (concordance rate = 93%) Conclusions: `Cardiac output measured by the bioreactance method is comparable to that from the thermodilution method. Bioreactance method may be used in clinical practice to assess hemodynamics and improve management of advanced heart failure patients undergoing heart transplant assessment.
PB  - Elsevier B.V.
T2  - Journal of Cardiothoracic and Vascular Anesthesia
T1  - Noninvasive Assessment of Cardiac Output in Advanced Heart Failure and Heart Transplant Candidates Using the Bioreactance Method
VL  - 35
IS  - 6
SP  - 1776
EP  - 1781
DO  - 10.1053/j.jvca.2020.09.109
ER  - 

@article{
author = "Pandhita, Bashar A.W. and Okwose, Nduka C. and Koshy, Aaron and Fernández, Óscar G. and Cruz, Noelia B. and Eggett, Christopher and Velicki, Lazar and Popović, Dejana and MacGowan, Guy A. and Jakovljević, Đorđe G.",
year = "2021",
abstract = "Objectives: The aim of the present study was to assess the validity and trending ability of the bioreactance method in estimating cardiac output at rest and in response to stress in advanced heart failure patients and heart transplant candidates. Design: This was a prospective single-center study. Setting: This study was conducted at the heart transplant center at the Freeman Hospital, Newcastle upon Tyne, UK. Participants: Eighteen patients with advanced chronic heart failure due to reduced left ventricular ejection fraction (19 ± 7%), and peak oxygen consumption 12.3 ± 3.9 mL/kg/min. Interventions: Participants underwent right heart catheterization using the Swan-Ganz catheter. Measurements and Main Results: Cardiac output was measured simultaneously using thermodilution and bioreactance at rest and during active straight leg raise test to volitional exertion. There was no significant difference in cardiac index values obtained by the thermodilution and bioreactance methods (2.26 ± 0.59 v 2.38 ± 0.50 L/min, p > 0.05) at rest and peak straight leg raise test (2.92 ± 0.77 v 3.01 ± 0.66 L/min, p > 0.05). In response to active leg raise test, thermodilution cardiac output increased by 22% and bioreactance by 21%. There was also a strong relationship between cardiac outputs from both methods at rest (r = 0.88, p < 0.01) and peak straight leg raise test (r = 0.92, p < 0.01). Cartesian plot analysis showed good trending ability of bioreactance compared with thermodilution (concordance rate = 93%) Conclusions: `Cardiac output measured by the bioreactance method is comparable to that from the thermodilution method. Bioreactance method may be used in clinical practice to assess hemodynamics and improve management of advanced heart failure patients undergoing heart transplant assessment.",
publisher = "Elsevier B.V.",
journal = "Journal of Cardiothoracic and Vascular Anesthesia",
title = "Noninvasive Assessment of Cardiac Output in Advanced Heart Failure and Heart Transplant Candidates Using the Bioreactance Method",
volume = "35",
number = "6",
pages = "1776-1781",
doi = "10.1053/j.jvca.2020.09.109"
}

Pandhita, B. A.W., Okwose, N. C., Koshy, A., Fernández, Ó. G., Cruz, N. B., Eggett, C., Velicki, L., Popović, D., MacGowan, G. A.,& Jakovljević, Đ. G.. (2021). Noninvasive Assessment of Cardiac Output in Advanced Heart Failure and Heart Transplant Candidates Using the Bioreactance Method. in Journal of Cardiothoracic and Vascular Anesthesia
Elsevier B.V.., 35(6), 1776-1781.
https://doi.org/10.1053/j.jvca.2020.09.109

Pandhita BA, Okwose NC, Koshy A, Fernández ÓG, Cruz NB, Eggett C, Velicki L, Popović D, MacGowan GA, Jakovljević ĐG. Noninvasive Assessment of Cardiac Output in Advanced Heart Failure and Heart Transplant Candidates Using the Bioreactance Method. in Journal of Cardiothoracic and Vascular Anesthesia. 2021;35(6):1776-1781.
doi:10.1053/j.jvca.2020.09.109 .

Pandhita, Bashar A.W., Okwose, Nduka C., Koshy, Aaron, Fernández, Óscar G., Cruz, Noelia B., Eggett, Christopher, Velicki, Lazar, Popović, Dejana, MacGowan, Guy A., Jakovljević, Đorđe G., "Noninvasive Assessment of Cardiac Output in Advanced Heart Failure and Heart Transplant Candidates Using the Bioreactance Method" in Journal of Cardiothoracic and Vascular Anesthesia, 35, no. 6 (2021):1776-1781,
https://doi.org/10.1053/j.jvca.2020.09.109 . .

TY  - JOUR
AU  - Vasilev, Vladimir
AU  - Popović, Dejana
AU  - Ristić, Gorica
AU  - Arena, Ross
AU  - Radunović, Goran
AU  - Ristić, Arsen
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3913
AB  - Background: Cardiovascular diseases are common cause of morbidity and mortality in patients with systemic connective tissue diseases (SCTD) due to accelerated atherosclerosis which couldn't be explained by traditional risk factors (CVDRF). Hypothesis: We hypothesized that recently developed score predicting probability of heart failure with preserved ejection fraction (H2FPEF), as well as a measure of right ventricular-pulmonary vasculature coupling [tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio], are predictive of atherosclerosis in SCTD. Methods: 203 patients (178 females) diagnosed with SCTD underwent standard and stress-echocardiography (SE) with TAPSE/PASP and left ventricular (LV) diastolic filling pressure (E/e') measurements, carotid ultrasound and computed tomographic coronary angiography. Patients who were SE positive for ischemia underwent coronary angiography (34/203). The H2FPEF score was calculated according to age, body mass index, presence of atrial fibrillation, ≥2 antihypertensives, E/e' and PASP. Results: Mean LV ejection fraction was 66.3 ± 7.1%. Atherosclerosis was present in 150/203 patients according to: 1) intima-media thickness>0.9 mm; and 2) Agatstone score > 300 or Syntax score ≥ 1. On binary logistic regression analysis, including CVDRF prevalence, echocardiographic parameters and H2FPEF score, only H2FPEF score remained significant for the prediction of atherosclerosis presence (χ2 = 19.3, HR 2.6, CI 1.5-4.3, p < 0.001), and resting TAPSE/PASP for the prediction of a SE positive for ischemia (χ2 = 10.4, HR 0.01, CI = 0.01-0.22, p = 0.004). On ROC analysis, the optimal threshold value for identifying patients with atherosclerosis was a H2FPEF score ≥2 (Sn 60.4%, Sp 69.4%, area 0.67, SE = 0.05, p < 0.001). Conclusions: H2FPEF score and resting TAPSE/PASP demonstrated clinical value for an atherosclerosis diagnosis in patients diagnosed with SCTD.
PB  - Wiley Periodicals
T2  - Clinical Cardiology
T1  - H2FPEF score predicts atherosclerosis presence in patients
with systemic connective tissue disease
DO  - 10.1002/clc.23621
ER  - 

@article{
author = "Vasilev, Vladimir and Popović, Dejana and Ristić, Gorica and Arena, Ross and Radunović, Goran and Ristić, Arsen",
year = "2021",
abstract = "Background: Cardiovascular diseases are common cause of morbidity and mortality in patients with systemic connective tissue diseases (SCTD) due to accelerated atherosclerosis which couldn't be explained by traditional risk factors (CVDRF). Hypothesis: We hypothesized that recently developed score predicting probability of heart failure with preserved ejection fraction (H2FPEF), as well as a measure of right ventricular-pulmonary vasculature coupling [tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio], are predictive of atherosclerosis in SCTD. Methods: 203 patients (178 females) diagnosed with SCTD underwent standard and stress-echocardiography (SE) with TAPSE/PASP and left ventricular (LV) diastolic filling pressure (E/e') measurements, carotid ultrasound and computed tomographic coronary angiography. Patients who were SE positive for ischemia underwent coronary angiography (34/203). The H2FPEF score was calculated according to age, body mass index, presence of atrial fibrillation, ≥2 antihypertensives, E/e' and PASP. Results: Mean LV ejection fraction was 66.3 ± 7.1%. Atherosclerosis was present in 150/203 patients according to: 1) intima-media thickness>0.9 mm; and 2) Agatstone score > 300 or Syntax score ≥ 1. On binary logistic regression analysis, including CVDRF prevalence, echocardiographic parameters and H2FPEF score, only H2FPEF score remained significant for the prediction of atherosclerosis presence (χ2 = 19.3, HR 2.6, CI 1.5-4.3, p < 0.001), and resting TAPSE/PASP for the prediction of a SE positive for ischemia (χ2 = 10.4, HR 0.01, CI = 0.01-0.22, p = 0.004). On ROC analysis, the optimal threshold value for identifying patients with atherosclerosis was a H2FPEF score ≥2 (Sn 60.4%, Sp 69.4%, area 0.67, SE = 0.05, p < 0.001). Conclusions: H2FPEF score and resting TAPSE/PASP demonstrated clinical value for an atherosclerosis diagnosis in patients diagnosed with SCTD.",
publisher = "Wiley Periodicals",
journal = "Clinical Cardiology",
title = "H2FPEF score predicts atherosclerosis presence in patients
with systemic connective tissue disease",
doi = "10.1002/clc.23621"
}

Vasilev, V., Popović, D., Ristić, G., Arena, R., Radunović, G.,& Ristić, A.. (2021). H2FPEF score predicts atherosclerosis presence in patients
with systemic connective tissue disease. in Clinical Cardiology
Wiley Periodicals..
https://doi.org/10.1002/clc.23621

Vasilev V, Popović D, Ristić G, Arena R, Radunović G, Ristić A. H2FPEF score predicts atherosclerosis presence in patients
with systemic connective tissue disease. in Clinical Cardiology. 2021;.
doi:10.1002/clc.23621 .

Vasilev, Vladimir, Popović, Dejana, Ristić, Gorica, Arena, Ross, Radunović, Goran, Ristić, Arsen, "H2FPEF score predicts atherosclerosis presence in patients
with systemic connective tissue disease" in Clinical Cardiology (2021),
https://doi.org/10.1002/clc.23621 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Đorđević, Tea
AU  - Jakovljević, Đorđe
AU  - Ristić, Arsen
AU  - Lasica, Ratko
AU  - Arena, Ross
AU  - Guazzi, Marco
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3580
AB  - Ischemic heart disease leading to heart failure (HF) portends a high overall morbidity and mortality. A higher N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) at rest reflects HF severity and impaired cardiac output, most often secondary to reduced ejection fraction (EF). As an insufficient increase in cardiac output during exertion is common in all HF phenotypes, we examined the value of NT-pro-BNP during exercise testing as a risk stratification index for ischemic HF secondary to either reduced (HFrEF) or mid-ranged/preserved EF (HFmrEF/HFpEF). 213 patients (123 HFrEF; 90 HFmrEF/HFpEF) underwent cardiopulmonary exercise testing (CPET). NT-pro-BNP was determined at rest and peak exercise. The distribution of HFrEF and HFmrEF/HFpEF etiology in subjects with and without oxygen consumption trajectory flattening during CPET was similar (p > 0.05). Patients with HFrEF had higher plasma levels of NT-pro-BNP at rest and peak exercise than those with HFmrEF/HFpEF (984 vs. 780; 1012 vs. 845 pg/mL, p < 0.01, respectively), whereas ΔNT-pro-BNPpeak/rest was similar (60 vs. 50 pg/mL, p > 0.05). During the tracking period (22.4 ± 20.3 months) 34 patients died, and there were 2 cardiac transplantations and 3 LVAD implantations. In a multivariate regression model only the NT-pro-BNPpeak and ΔNT-pro-BNPpeak/rest were retained in the regression for the prediction of adverse events (Chi-square:8.97, p = 0.003). ROC analysis demonstrated that NT-pro-BNPpeak ≥1506 pg/mL and ΔNT-pro-BNPpeak/rest ≥108 pg/mL were optimal for identifying patients with a risk (Sn = 76.9, 74.4 %; Sp = 84.7, 80.9 %, respectively). NT-pro-BNP changes during effort and absolute peak values reached provide novel insights emerging as new and strong predictors of adverse events in HF of any EF.
PB  - Elsevier
T2  - Peptides
T1  - N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction
VL  - 129
DO  - 10.1016/j.peptides.2020.170315
DO  - 10.1016/j.peptides.2020.170315
ER  - 

@article{
author = "Popović, Dejana and Đorđević, Tea and Jakovljević, Đorđe and Ristić, Arsen and Lasica, Ratko and Arena, Ross and Guazzi, Marco",
year = "2020",
abstract = "Ischemic heart disease leading to heart failure (HF) portends a high overall morbidity and mortality. A higher N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) at rest reflects HF severity and impaired cardiac output, most often secondary to reduced ejection fraction (EF). As an insufficient increase in cardiac output during exertion is common in all HF phenotypes, we examined the value of NT-pro-BNP during exercise testing as a risk stratification index for ischemic HF secondary to either reduced (HFrEF) or mid-ranged/preserved EF (HFmrEF/HFpEF). 213 patients (123 HFrEF; 90 HFmrEF/HFpEF) underwent cardiopulmonary exercise testing (CPET). NT-pro-BNP was determined at rest and peak exercise. The distribution of HFrEF and HFmrEF/HFpEF etiology in subjects with and without oxygen consumption trajectory flattening during CPET was similar (p > 0.05). Patients with HFrEF had higher plasma levels of NT-pro-BNP at rest and peak exercise than those with HFmrEF/HFpEF (984 vs. 780; 1012 vs. 845 pg/mL, p < 0.01, respectively), whereas ΔNT-pro-BNPpeak/rest was similar (60 vs. 50 pg/mL, p > 0.05). During the tracking period (22.4 ± 20.3 months) 34 patients died, and there were 2 cardiac transplantations and 3 LVAD implantations. In a multivariate regression model only the NT-pro-BNPpeak and ΔNT-pro-BNPpeak/rest were retained in the regression for the prediction of adverse events (Chi-square:8.97, p = 0.003). ROC analysis demonstrated that NT-pro-BNPpeak ≥1506 pg/mL and ΔNT-pro-BNPpeak/rest ≥108 pg/mL were optimal for identifying patients with a risk (Sn = 76.9, 74.4 %; Sp = 84.7, 80.9 %, respectively). NT-pro-BNP changes during effort and absolute peak values reached provide novel insights emerging as new and strong predictors of adverse events in HF of any EF.",
publisher = "Elsevier",
journal = "Peptides",
title = "N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction",
volume = "129",
doi = "10.1016/j.peptides.2020.170315, 10.1016/j.peptides.2020.170315"
}

Popović, D., Đorđević, T., Jakovljević, Đ., Ristić, A., Lasica, R., Arena, R.,& Guazzi, M.. (2020). N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction. in Peptides
Elsevier., 129.
https://doi.org/10.1016/j.peptides.2020.170315

Popović D, Đorđević T, Jakovljević Đ, Ristić A, Lasica R, Arena R, Guazzi M. N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction. in Peptides. 2020;129.
doi:10.1016/j.peptides.2020.170315 .

Popović, Dejana, Đorđević, Tea, Jakovljević, Đorđe, Ristić, Arsen, Lasica, Ratko, Arena, Ross, Guazzi, Marco, "N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction" in Peptides, 129 (2020),
https://doi.org/10.1016/j.peptides.2020.170315 . .

TY  - JOUR
AU  - Juhas, Irina
AU  - Skof, Branko
AU  - Popović, Dejana
AU  - Matić, Milan
AU  - Janković, Nenad
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3279
AB  - Increased lipid levels are one of the major risk factors for the development of cardiovascular diseases. The aim of the current study was to evaluate the effect of short-term (8 weeks) aerobic exercise of moderate to vigorous intensity on lipid profile in young healthy females. 27 female students (mean age 20.5 ± 1 year) completed 8 weeks of aerobic training that included two exercise sessions of continuous aerobic activity of moderate intensity (running 35-60 min) and one exercise session with interval training of vigorous intensity. Intervention aerobic capacity and lipid profile were examined before and after the exercise. Exercise intervention has caused a decrease of low density lipoprotein levels per 9.8% (from 2.52 ± 0.47 to 2.27 ± 0.53 mmol/L; p < 0.001) and significant improvement of high density lipoprotein (HDL) levels per 22.7% (from 1.29 ± 0.24 to 1.59 ± 0.24 mmol/L; p < 0.001), total cholesterol/HDL ratio per 17.2 % and aerobic capacity (VO 2 ma x) per 3.8 % (43.9 ± 3.7 to 45.56 ± 3.63 mLO 2 /kg/min). The results support the hypothesis that a short-term aerobic exercise intervention of moderate to vigorous intensity may have significant effects on blood lipid profile in young healthy females.
AB  - Uvod:Pove}ani  nivo  lipida  je  jedan  od  zna~ajnih  faktorarizika  za  razvoj  kardiovaskularnih  bolesti.  Cilj  ovog  istra  `i -vanja je da se procene efekti kratkog (8 nedelja) aerobnogve`banja,  umerenog  do  visokog  intenziteta,  na  lipidniprofil.Metode:27 studentkinja (prose~ne starosti 20,5 ± 1 godi -na) je izlo`eno osmonedeljnom aerobnom ve`banju koje sesastojalo od treninga kontinuirane aerobne aktivnosti ume -renog intenziteta (tr~anje 35–60 min) dva puta nedeljno iintervalnog  treninga  visokog  intenziteta  jednom  nedeljno.Lipidni profil je odre|en pre i posle programa ve`banja.  Rezultati:Program  ve`banja  je  doveo  do  smanjenja  nivoa»lo{eg«  holesterola  za  9,8%  (od  2,52  ±  0,47  na  2,27  ±0,53 mmol/L; p < 0,001), zna~ajnog pove}anja »dobrog«holesterola (HDL) za 22,7% (od 1,29 ± 0,24 na 1,59 ±0,24  mmol/L;  p  <  0,001),  odnosa  ukupnog  holeste  -rola/HDL  za  17,2%  i  pobolj{anja  aerobnog  kapaciteta(VO2  max)  za  3,8%  (od  43,9  ±  3,7  na  45,56  ±  3,63mLO2/kg/min). Zaklju~ak:Rezultati  istra`ivanja  podr`avaju  hipotezu  dakratkotrajno  aerobno  ve`banje  od  umerenog  do  visokogintenziteta  ima  zna~ajan  uticaj  na  lipidni  profil  mladih,zdravih, `enskih osoba.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Effects of an eight-week exercise program on parameters of the lipid profile of female students
T1  - EFEKTI OSMONEDELJNOG PROGRAMA VEŽBANJA NA LIPIDNI PROFIL STUDENTKINJA
VL  - 39
IS  - 1
SP  - 40
EP  - 45
DO  - 10.2478/jomb-2019-0006
ER  - 

@article{
author = "Juhas, Irina and Skof, Branko and Popović, Dejana and Matić, Milan and Janković, Nenad",
year = "2020",
abstract = "Increased lipid levels are one of the major risk factors for the development of cardiovascular diseases. The aim of the current study was to evaluate the effect of short-term (8 weeks) aerobic exercise of moderate to vigorous intensity on lipid profile in young healthy females. 27 female students (mean age 20.5 ± 1 year) completed 8 weeks of aerobic training that included two exercise sessions of continuous aerobic activity of moderate intensity (running 35-60 min) and one exercise session with interval training of vigorous intensity. Intervention aerobic capacity and lipid profile were examined before and after the exercise. Exercise intervention has caused a decrease of low density lipoprotein levels per 9.8% (from 2.52 ± 0.47 to 2.27 ± 0.53 mmol/L; p &lt; 0.001) and significant improvement of high density lipoprotein (HDL) levels per 22.7% (from 1.29 ± 0.24 to 1.59 ± 0.24 mmol/L; p &lt; 0.001), total cholesterol/HDL ratio per 17.2 % and aerobic capacity (VO 2 ma x) per 3.8 % (43.9 ± 3.7 to 45.56 ± 3.63 mLO 2 /kg/min). The results support the hypothesis that a short-term aerobic exercise intervention of moderate to vigorous intensity may have significant effects on blood lipid profile in young healthy females., Uvod:Pove}ani  nivo  lipida  je  jedan  od  zna~ajnih  faktorarizika  za  razvoj  kardiovaskularnih  bolesti.  Cilj  ovog  istra  `i -vanja je da se procene efekti kratkog (8 nedelja) aerobnogve`banja,  umerenog  do  visokog  intenziteta,  na  lipidniprofil.Metode:27 studentkinja (prose~ne starosti 20,5 ± 1 godi -na) je izlo`eno osmonedeljnom aerobnom ve`banju koje sesastojalo od treninga kontinuirane aerobne aktivnosti ume -renog intenziteta (tr~anje 35–60 min) dva puta nedeljno iintervalnog  treninga  visokog  intenziteta  jednom  nedeljno.Lipidni profil je odre|en pre i posle programa ve`banja.  Rezultati:Program  ve`banja  je  doveo  do  smanjenja  nivoa»lo{eg«  holesterola  za  9,8%  (od  2,52  ±  0,47  na  2,27  ±0,53 mmol/L; p < 0,001), zna~ajnog pove}anja »dobrog«holesterola (HDL) za 22,7% (od 1,29 ± 0,24 na 1,59 ±0,24  mmol/L;  p  <  0,001),  odnosa  ukupnog  holeste  -rola/HDL  za  17,2%  i  pobolj{anja  aerobnog  kapaciteta(VO2  max)  za  3,8%  (od  43,9  ±  3,7  na  45,56  ±  3,63mLO2/kg/min). Zaklju~ak:Rezultati  istra`ivanja  podr`avaju  hipotezu  dakratkotrajno  aerobno  ve`banje  od  umerenog  do  visokogintenziteta  ima  zna~ajan  uticaj  na  lipidni  profil  mladih,zdravih, `enskih osoba.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Effects of an eight-week exercise program on parameters of the lipid profile of female students, EFEKTI OSMONEDELJNOG PROGRAMA VEŽBANJA NA LIPIDNI PROFIL STUDENTKINJA",
volume = "39",
number = "1",
pages = "40-45",
doi = "10.2478/jomb-2019-0006"
}

Juhas, I., Skof, B., Popović, D., Matić, M.,& Janković, N.. (2020). Effects of an eight-week exercise program on parameters of the lipid profile of female students. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 39(1), 40-45.
https://doi.org/10.2478/jomb-2019-0006

Juhas I, Skof B, Popović D, Matić M, Janković N. Effects of an eight-week exercise program on parameters of the lipid profile of female students. in Journal of Medical Biochemistry. 2020;39(1):40-45.
doi:10.2478/jomb-2019-0006 .

Juhas, Irina, Skof, Branko, Popović, Dejana, Matić, Milan, Janković, Nenad, "Effects of an eight-week exercise program on parameters of the lipid profile of female students" in Journal of Medical Biochemistry, 39, no. 1 (2020):40-45,
https://doi.org/10.2478/jomb-2019-0006 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Guazzi, Marco
AU  - Jakovljević, Đorđe G.
AU  - Lasica, Ratko
AU  - Banović, Marko
AU  - Ostojić, Miodrag
AU  - Arena, Ross
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3316
AB  - Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p  lt  0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.
PB  - Elsevier Ireland Ltd, Clare
T2  - International Journal of Cardiology
T1  - Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing
VL  - 285
SP  - 11
EP  - 13
DO  - 10.1016/j.ijcard.2019.03.012
ER  - 

@article{
author = "Popović, Dejana and Guazzi, Marco and Jakovljević, Đorđe G. and Lasica, Ratko and Banović, Marko and Ostojić, Miodrag and Arena, Ross",
year = "2019",
abstract = "Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p  lt  0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "International Journal of Cardiology",
title = "Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing",
volume = "285",
pages = "11-13",
doi = "10.1016/j.ijcard.2019.03.012"
}

Popović, D., Guazzi, M., Jakovljević, Đ. G., Lasica, R., Banović, M., Ostojić, M.,& Arena, R.. (2019). Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing. in International Journal of Cardiology
Elsevier Ireland Ltd, Clare., 285, 11-13.
https://doi.org/10.1016/j.ijcard.2019.03.012

Popović D, Guazzi M, Jakovljević ĐG, Lasica R, Banović M, Ostojić M, Arena R. Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing. in International Journal of Cardiology. 2019;285:11-13.
doi:10.1016/j.ijcard.2019.03.012 .

Popović, Dejana, Guazzi, Marco, Jakovljević, Đorđe G., Lasica, Ratko, Banović, Marko, Ostojić, Miodrag, Arena, Ross, "Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing" in International Journal of Cardiology, 285 (2019):11-13,
https://doi.org/10.1016/j.ijcard.2019.03.012 . .

TY  - JOUR
AU  - Suryanegara, Jose
AU  - Cassidy, Sophie
AU  - Ninković, Vladan
AU  - Popović, Dejana
AU  - Grbović, Miljan
AU  - Okwose, Nduka
AU  - Trenell, Michael I.
AU  - MacGowan, Guy G.
AU  - Jakovljević, Đorđe G.
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3303
AB  - AimThe present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes.MethodsTwenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention.ResultsAt baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.36.1 vs. 21.75.5ml/kg/min, p=0.21), and peak exercise heart rate (156.3 +/- 15.0 vs. 153.8 +/- 12.5 beats/min, p=0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 +/- 2.4 vs. 15.2 +/- 2.2ml/min/kg, p=0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 +/- 2.7-12.8 +/- 3.6L/min, p=0.03), but not in the control group (15.7 +/- 4.9-16.3 +/- 4.1L/min, p=0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p=0.03) and heart rate by 9% (p=0.04).Conclusion Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.Trial registration ISRCTN78698481. Registered 23 January 2013, retrospectively registered.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Acta Diabetologica
T1  - High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial
VL  - 56
IS  - 3
SP  - 321
EP  - 329
DO  - 10.1007/s00592-018-1245-5
ER  - 

@article{
author = "Suryanegara, Jose and Cassidy, Sophie and Ninković, Vladan and Popović, Dejana and Grbović, Miljan and Okwose, Nduka and Trenell, Michael I. and MacGowan, Guy G. and Jakovljević, Đorđe G.",
year = "2019",
abstract = "AimThe present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes.MethodsTwenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention.ResultsAt baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.36.1 vs. 21.75.5ml/kg/min, p=0.21), and peak exercise heart rate (156.3 +/- 15.0 vs. 153.8 +/- 12.5 beats/min, p=0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 +/- 2.4 vs. 15.2 +/- 2.2ml/min/kg, p=0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 +/- 2.7-12.8 +/- 3.6L/min, p=0.03), but not in the control group (15.7 +/- 4.9-16.3 +/- 4.1L/min, p=0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p=0.03) and heart rate by 9% (p=0.04).Conclusion Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.Trial registration ISRCTN78698481. Registered 23 January 2013, retrospectively registered.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Acta Diabetologica",
title = "High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial",
volume = "56",
number = "3",
pages = "321-329",
doi = "10.1007/s00592-018-1245-5"
}

Suryanegara, J., Cassidy, S., Ninković, V., Popović, D., Grbović, M., Okwose, N., Trenell, M. I., MacGowan, G. G.,& Jakovljević, Đ. G.. (2019). High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. in Acta Diabetologica
Springer-Verlag Italia Srl, Milan., 56(3), 321-329.
https://doi.org/10.1007/s00592-018-1245-5

Suryanegara J, Cassidy S, Ninković V, Popović D, Grbović M, Okwose N, Trenell MI, MacGowan GG, Jakovljević ĐG. High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial. in Acta Diabetologica. 2019;56(3):321-329.
doi:10.1007/s00592-018-1245-5 .

Suryanegara, Jose, Cassidy, Sophie, Ninković, Vladan, Popović, Dejana, Grbović, Miljan, Okwose, Nduka, Trenell, Michael I., MacGowan, Guy G., Jakovljević, Đorđe G., "High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial" in Acta Diabetologica, 56, no. 3 (2019):321-329,
https://doi.org/10.1007/s00592-018-1245-5 . .

TY  - JOUR
AU  - Milutinović, Katarina
AU  - Stojiljković, Stanimir
AU  - Ćuk, Jelena
AU  - Lasica, Ratko
AU  - Miosavljević, Andrej
AU  - Cvetković, Dimitrije
AU  - Trajković, Aleksandra
AU  - Pešić, Vesna
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3111
AB  - The athlete's heart is a set of morphological and functional characteristics that develop over time due to sports training. These adaptive changes result in increase in cardiac work efficiency and economy. They are manidested as cardiac muscle hypertrophy and dilation, with accompanying angiogenesis and slower heart rate, that are influenced by variable regulatory systems and genetic predisposition. The problem of sudden cardiac death in athletes, which persists despite numerous activities aimed at prevention, creates the need for a better definition of the athlete's heart, especially in terms of its differentiation from certain pathological conditions. This is of particular importance in the context of cardiac electrical activity. Right heart adaptations, hormonal regulatory mechanisms and the effects of nonphysiological adaptations during training, that may lead to pathologic alterations direction, are all relevant in the investigation of adverse cardiac events in athletes. In order to prevent sudden cardiac death in athletes, it is necessary to examine competitive athletes as well as apparently health individuals who recreationally exercise at a high volume. There are guidelines for mass screening and individual examinations, for all age groups and both genders, as well as for public service staff who require intense physical activity during their occupation. Both American and European recommendations require a detailed anamnesis and physical examination, whereas European, apart from that, require initial electrocardiography. The implementation of additional tests is necessary if the existence of any underlying pathophysiologic process is suspected. Checks should be performed before engaging in sports activities, as well as during training and competition periods.
AB  - Sportsko srce predstavlja efekat morfoloških i funkcionalnih adaptacija srca koje se razvijaju tokom vremena, pod uticajem sportskog treninga. Promene na srcu kod sportista za posledicu imaju promenu efikasnosti i ekonomičnosti srčanog rada. Manifestuju se hipertrofijom i dilatacijom srca, sa pratećom angiogenezom i usporenim srčanim radom, procesima koji su pod kontrolom različitih regulatornih sistema i genetske predispozicije. Problem iznenadne srčane smrti u sportu, čija se incidenca ne smanjuje uprkos brojnim aktivnostima koje se sprovode u cilju njene prevencije, nameće potrebu boljeg definisanja sportskog srca, naročito u smislu njegovog razlikovanja od pojedinih patoloških stanja. Kod izvesnog broja sportista uočavaju se promene električne aktivnosti, te je i u tom smislu potrebno razlikovati zdravo od bolesnog srca. Poslednjih godina posebno je u fokusu definisanje adaptivnih promena desnog srca. Dodatno, postoje nova saznanja o hormonskoj regulaciji adaptivnih promena srca sportista, a istražuju se i efekti nefizioloških manipulacija u trenažnom procesu koji mogu 'skrenuti' fiziološke procese u patološkom pravcu. U cilju prevencije iznenadne srčane smrti, neophodno je redovno pregledanje kako sportista, tako i fizički aktivnog dela populacije. Aktuelne preporuke daju smernice za masovne skrininge i individualne preglede sportista, za sve starosne grupe oba pola, kao i pripadnike javnih službi koje u opisu posla imaju intenzivne fizičke napore. Dok američke preporuke zahtevaju samo detaljnu anamnezu i fizikalni pregled, evropske preporuke zahtevaju i inicijalnu elektrokardiografiju. I evropske i američke preporuke zahtevaju sprovođenje dodatnih ispitivanja kod sumnje na postojanje bilo kakvog oboljenja. Ove preglede bi trebalo obavljati pre početka trenažnog procesa, kao i tokom perioda treniranja i takmičenja.
PB  - Univerzitet u Beogradu - Fakultet sporta i fizičkog vaspitanja, Beograd
T2  - Fizička kultura
T1  - Athlete's heart
T1  - Corazon de deportista
T1  - Sportsko srce
VL  - 72
IS  - 2
SP  - 139
EP  - 147
DO  - 10.5937/fizkul1802139M
ER  - 

@article{
author = "Milutinović, Katarina and Stojiljković, Stanimir and Ćuk, Jelena and Lasica, Ratko and Miosavljević, Andrej and Cvetković, Dimitrije and Trajković, Aleksandra and Pešić, Vesna and Arena, Ross and Popović, Dejana",
year = "2018",
abstract = "The athlete's heart is a set of morphological and functional characteristics that develop over time due to sports training. These adaptive changes result in increase in cardiac work efficiency and economy. They are manidested as cardiac muscle hypertrophy and dilation, with accompanying angiogenesis and slower heart rate, that are influenced by variable regulatory systems and genetic predisposition. The problem of sudden cardiac death in athletes, which persists despite numerous activities aimed at prevention, creates the need for a better definition of the athlete's heart, especially in terms of its differentiation from certain pathological conditions. This is of particular importance in the context of cardiac electrical activity. Right heart adaptations, hormonal regulatory mechanisms and the effects of nonphysiological adaptations during training, that may lead to pathologic alterations direction, are all relevant in the investigation of adverse cardiac events in athletes. In order to prevent sudden cardiac death in athletes, it is necessary to examine competitive athletes as well as apparently health individuals who recreationally exercise at a high volume. There are guidelines for mass screening and individual examinations, for all age groups and both genders, as well as for public service staff who require intense physical activity during their occupation. Both American and European recommendations require a detailed anamnesis and physical examination, whereas European, apart from that, require initial electrocardiography. The implementation of additional tests is necessary if the existence of any underlying pathophysiologic process is suspected. Checks should be performed before engaging in sports activities, as well as during training and competition periods., Sportsko srce predstavlja efekat morfoloških i funkcionalnih adaptacija srca koje se razvijaju tokom vremena, pod uticajem sportskog treninga. Promene na srcu kod sportista za posledicu imaju promenu efikasnosti i ekonomičnosti srčanog rada. Manifestuju se hipertrofijom i dilatacijom srca, sa pratećom angiogenezom i usporenim srčanim radom, procesima koji su pod kontrolom različitih regulatornih sistema i genetske predispozicije. Problem iznenadne srčane smrti u sportu, čija se incidenca ne smanjuje uprkos brojnim aktivnostima koje se sprovode u cilju njene prevencije, nameće potrebu boljeg definisanja sportskog srca, naročito u smislu njegovog razlikovanja od pojedinih patoloških stanja. Kod izvesnog broja sportista uočavaju se promene električne aktivnosti, te je i u tom smislu potrebno razlikovati zdravo od bolesnog srca. Poslednjih godina posebno je u fokusu definisanje adaptivnih promena desnog srca. Dodatno, postoje nova saznanja o hormonskoj regulaciji adaptivnih promena srca sportista, a istražuju se i efekti nefizioloških manipulacija u trenažnom procesu koji mogu 'skrenuti' fiziološke procese u patološkom pravcu. U cilju prevencije iznenadne srčane smrti, neophodno je redovno pregledanje kako sportista, tako i fizički aktivnog dela populacije. Aktuelne preporuke daju smernice za masovne skrininge i individualne preglede sportista, za sve starosne grupe oba pola, kao i pripadnike javnih službi koje u opisu posla imaju intenzivne fizičke napore. Dok američke preporuke zahtevaju samo detaljnu anamnezu i fizikalni pregled, evropske preporuke zahtevaju i inicijalnu elektrokardiografiju. I evropske i američke preporuke zahtevaju sprovođenje dodatnih ispitivanja kod sumnje na postojanje bilo kakvog oboljenja. Ove preglede bi trebalo obavljati pre početka trenažnog procesa, kao i tokom perioda treniranja i takmičenja.",
publisher = "Univerzitet u Beogradu - Fakultet sporta i fizičkog vaspitanja, Beograd",
journal = "Fizička kultura",
title = "Athlete's heart, Corazon de deportista, Sportsko srce",
volume = "72",
number = "2",
pages = "139-147",
doi = "10.5937/fizkul1802139M"
}

Milutinović, K., Stojiljković, S., Ćuk, J., Lasica, R., Miosavljević, A., Cvetković, D., Trajković, A., Pešić, V., Arena, R.,& Popović, D.. (2018). Athlete's heart. in Fizička kultura
Univerzitet u Beogradu - Fakultet sporta i fizičkog vaspitanja, Beograd., 72(2), 139-147.
https://doi.org/10.5937/fizkul1802139M

Milutinović K, Stojiljković S, Ćuk J, Lasica R, Miosavljević A, Cvetković D, Trajković A, Pešić V, Arena R, Popović D. Athlete's heart. in Fizička kultura. 2018;72(2):139-147.
doi:10.5937/fizkul1802139M .

Milutinović, Katarina, Stojiljković, Stanimir, Ćuk, Jelena, Lasica, Ratko, Miosavljević, Andrej, Cvetković, Dimitrije, Trajković, Aleksandra, Pešić, Vesna, Arena, Ross, Popović, Dejana, "Athlete's heart" in Fizička kultura, 72, no. 2 (2018):139-147,
https://doi.org/10.5937/fizkul1802139M . .

TY  - JOUR
AU  - Ćuk, Jelena
AU  - Stojiljković, Stanimir
AU  - Milutinović, Katarina
AU  - Cvetković, Dimitrije
AU  - Pešić, Vesna
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3102
AB  - The athlete's heart is an exercise-induced cardiac remodeling phenomenon, which is individual and depends on the intensity, duration and frequency of training, as well as genetic factors. Cardiovascular screening prior to participation in sports activities, is a systematic practice of medical evaluation in the athlete population. The current US recommendations for the screening of cardiovascular abnormalities in high school and university athletes at all levels of performance were initially put forther by the American Heart Association in 2007. These recommendations consist of 12 points, factoring personal and family history data, as well as physical examination. On the other hand, European recommendations suggest the importance of non-invasive diagnostic methods, such as the 12-lead ECG, which should be carried out in combination with a history and physical examination. According to the European Association for Cardiovascular Imaging, standard echocardiography is the first line approach to differentiate an athlete's heart from pathological left ventricular hypertrophy. Updated 'Seattle criteria' from 2017. include criteria for assessing abnormalities in the electrocardiogram of athletes and their differentiation from the adaptive electrophysiological changes, which do not require further evaluation. Since sudden cardiac death during sport activities remains a major concern and, as such, it is imperative for the physician to diagnose unrecognized pathological conditions in athletes. Following current expert consensus recommendations on this topic helps to prevent untoward events during physical activity in those who are found to be at elevated risk.
AB  - Atletsko srce je fenomen remodelovanja srčanog mišića, koje je nastalo usled fizičke aktivnosti, a čiji stepen zavisi od intenziteta, trajanja, učestalosti treniranja, individualnih osobina i genetskih faktora. Aktuelne američke preporuke za skrining kardiovaskularnih abnormalnosti među sportistima srednjoškolcima i studentima svih nivoa utreniranosti, inicijalno su bile postavljene od strane Američkog udruženja kardiologa 2007. godine. Ove preporuke čini 12 tačaka i podrazumevaju podatke iz lične i porodične istorije bolesti, kao i fizičkog pregleda. S druge strane, evropske preporuke sugerišu na značaj neinvazivnih dijagnostičkih metoda, kao što je 12-kanalni EKG, čiji rezultati bi trebali biti razmatrani udruženo sa istorijom bolesti i fizičkim pregledom. Prema Evropskom udruženju za kardiovakularni imidžing, standardna ehokardiografija je prva dijagnostička metoda diferencijacije sportskog srca od patološke hipertrofije leve komore. Godine 2012, Američko udruženje za sportsku medicine je definisalo kriterijume, koji su osveženi 2017. godine, za utvrđivanje abnormalnosti u elektrokardiogramu sportista i njihovu diferencijaciju od adaptivnih elektrofizoloških promena, koje ne zahtevaju dalju evaluaciju. S obzirom na to da iznenadna srčana smrt u sportu zahteva veliku pažnju, neophodno je da lekari budu edukovani da dijagnostikuju neprepoznata patološka stanja kod sportista. Praćenje aktuelnih preporuka koje se bave ovim problemom doprinosi prevenciji neželjenih događaja u sportu i kod osoba koje su iz drugih razloga izložene velikim fizičkim naporima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - The athlete's heart: Modern diagnostic approach
T1  - Sportsko srce - savremeni dijagnostički pristup
VL  - 68
IS  - 4
SP  - 900
EP  - 910
DO  - 10.5937/ArhFarm1804900C
ER  - 

@article{
author = "Ćuk, Jelena and Stojiljković, Stanimir and Milutinović, Katarina and Cvetković, Dimitrije and Pešić, Vesna and Arena, Ross and Popović, Dejana",
year = "2018",
abstract = "The athlete's heart is an exercise-induced cardiac remodeling phenomenon, which is individual and depends on the intensity, duration and frequency of training, as well as genetic factors. Cardiovascular screening prior to participation in sports activities, is a systematic practice of medical evaluation in the athlete population. The current US recommendations for the screening of cardiovascular abnormalities in high school and university athletes at all levels of performance were initially put forther by the American Heart Association in 2007. These recommendations consist of 12 points, factoring personal and family history data, as well as physical examination. On the other hand, European recommendations suggest the importance of non-invasive diagnostic methods, such as the 12-lead ECG, which should be carried out in combination with a history and physical examination. According to the European Association for Cardiovascular Imaging, standard echocardiography is the first line approach to differentiate an athlete's heart from pathological left ventricular hypertrophy. Updated 'Seattle criteria' from 2017. include criteria for assessing abnormalities in the electrocardiogram of athletes and their differentiation from the adaptive electrophysiological changes, which do not require further evaluation. Since sudden cardiac death during sport activities remains a major concern and, as such, it is imperative for the physician to diagnose unrecognized pathological conditions in athletes. Following current expert consensus recommendations on this topic helps to prevent untoward events during physical activity in those who are found to be at elevated risk., Atletsko srce je fenomen remodelovanja srčanog mišića, koje je nastalo usled fizičke aktivnosti, a čiji stepen zavisi od intenziteta, trajanja, učestalosti treniranja, individualnih osobina i genetskih faktora. Aktuelne američke preporuke za skrining kardiovaskularnih abnormalnosti među sportistima srednjoškolcima i studentima svih nivoa utreniranosti, inicijalno su bile postavljene od strane Američkog udruženja kardiologa 2007. godine. Ove preporuke čini 12 tačaka i podrazumevaju podatke iz lične i porodične istorije bolesti, kao i fizičkog pregleda. S druge strane, evropske preporuke sugerišu na značaj neinvazivnih dijagnostičkih metoda, kao što je 12-kanalni EKG, čiji rezultati bi trebali biti razmatrani udruženo sa istorijom bolesti i fizičkim pregledom. Prema Evropskom udruženju za kardiovakularni imidžing, standardna ehokardiografija je prva dijagnostička metoda diferencijacije sportskog srca od patološke hipertrofije leve komore. Godine 2012, Američko udruženje za sportsku medicine je definisalo kriterijume, koji su osveženi 2017. godine, za utvrđivanje abnormalnosti u elektrokardiogramu sportista i njihovu diferencijaciju od adaptivnih elektrofizoloških promena, koje ne zahtevaju dalju evaluaciju. S obzirom na to da iznenadna srčana smrt u sportu zahteva veliku pažnju, neophodno je da lekari budu edukovani da dijagnostikuju neprepoznata patološka stanja kod sportista. Praćenje aktuelnih preporuka koje se bave ovim problemom doprinosi prevenciji neželjenih događaja u sportu i kod osoba koje su iz drugih razloga izložene velikim fizičkim naporima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The athlete's heart: Modern diagnostic approach, Sportsko srce - savremeni dijagnostički pristup",
volume = "68",
number = "4",
pages = "900-910",
doi = "10.5937/ArhFarm1804900C"
}

Ćuk, J., Stojiljković, S., Milutinović, K., Cvetković, D., Pešić, V., Arena, R.,& Popović, D.. (2018). The athlete's heart: Modern diagnostic approach. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(4), 900-910.
https://doi.org/10.5937/ArhFarm1804900C

Ćuk J, Stojiljković S, Milutinović K, Cvetković D, Pešić V, Arena R, Popović D. The athlete's heart: Modern diagnostic approach. in Arhiv za farmaciju. 2018;68(4):900-910.
doi:10.5937/ArhFarm1804900C .

Ćuk, Jelena, Stojiljković, Stanimir, Milutinović, Katarina, Cvetković, Dimitrije, Pešić, Vesna, Arena, Ross, Popović, Dejana, "The athlete's heart: Modern diagnostic approach" in Arhiv za farmaciju, 68, no. 4 (2018):900-910,
https://doi.org/10.5937/ArhFarm1804900C . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Petrović, Marija
AU  - Milasinović, Goran
AU  - Vujisić-Tesić, Bosiljka
AU  - Trifunović, Danijela
AU  - Petrović, Olga
AU  - Nedeljković, Ivana
AU  - Petrović, Ivana
AU  - Banović, Marko
AU  - Boricić-Kostić, Marija
AU  - Petrović, Jelena
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2918
AB  - Aims: Selection of patients who are viable candidates for cardiac resynchronization therapy (CRT), prediction of the response to CRT as well as an optimal definition of a favorable response, all require further exploration. The purpose of this study was to evaluate the interplay between the prediction of the response to CRT and the definition of a favorable outcome. Methods: Seventy patients who received CRT were included. All patients met current guideline criteria for CRT. Forty-three echocardiographic parameters were evaluated before CRT and at 1, 3, 6, and 12 months. M-mode, 2D echocardiography, and Doppler imaging were used to quantify left ventricular (LV) systolic and diastolic function, mitral regurgitation, right ventricular systolic function, pulmonary artery pressure, and myocardial mechanical dyssynchrony. The following definitions of a favorable CRT response were used: left ventricular ejection fraction (LVEF) improvement more >5% acutely following CRT, LVEF improvement >20% at 12-month follow-up, and a LV end-systolic volume (LVESV) decrease >15% at 12-month follow-up. Results: For the LVEF improvement >5%, the best predictor was isovolumetric relaxation time (IVRT; P=.035). For improvement of LVEF >20%, the best predictors were left ventricular stroke index (LVSI; P=.044) and left ventricular fractional shortening (LVFS; P=.031). For the drop in left ventricular systolic volume (LVESV >15%), the best predictor was septal-to-lateral wall delay (Delta T) (P=.043, RR=1.023, 95% CI for RR=1.001-1.045). Conclusion: The definition of a favorable CRT response influenced the optimal predictor variable(s). Standardization of defining a favorable response to CRT is needed to guide clinical decision making processes.
PB  - Wiley, Hoboken
T2  - Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
T1  - Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome
VL  - 34
IS  - 3
SP  - 371
EP  - 375
DO  - 10.1111/echo.13453
ER  - 

@article{
author = "Petrović, Milan and Petrović, Marija and Milasinović, Goran and Vujisić-Tesić, Bosiljka and Trifunović, Danijela and Petrović, Olga and Nedeljković, Ivana and Petrović, Ivana and Banović, Marko and Boricić-Kostić, Marija and Petrović, Jelena and Arena, Ross and Popović, Dejana",
year = "2017",
abstract = "Aims: Selection of patients who are viable candidates for cardiac resynchronization therapy (CRT), prediction of the response to CRT as well as an optimal definition of a favorable response, all require further exploration. The purpose of this study was to evaluate the interplay between the prediction of the response to CRT and the definition of a favorable outcome. Methods: Seventy patients who received CRT were included. All patients met current guideline criteria for CRT. Forty-three echocardiographic parameters were evaluated before CRT and at 1, 3, 6, and 12 months. M-mode, 2D echocardiography, and Doppler imaging were used to quantify left ventricular (LV) systolic and diastolic function, mitral regurgitation, right ventricular systolic function, pulmonary artery pressure, and myocardial mechanical dyssynchrony. The following definitions of a favorable CRT response were used: left ventricular ejection fraction (LVEF) improvement more >5% acutely following CRT, LVEF improvement >20% at 12-month follow-up, and a LV end-systolic volume (LVESV) decrease >15% at 12-month follow-up. Results: For the LVEF improvement >5%, the best predictor was isovolumetric relaxation time (IVRT; P=.035). For improvement of LVEF >20%, the best predictors were left ventricular stroke index (LVSI; P=.044) and left ventricular fractional shortening (LVFS; P=.031). For the drop in left ventricular systolic volume (LVESV >15%), the best predictor was septal-to-lateral wall delay (Delta T) (P=.043, RR=1.023, 95% CI for RR=1.001-1.045). Conclusion: The definition of a favorable CRT response influenced the optimal predictor variable(s). Standardization of defining a favorable response to CRT is needed to guide clinical decision making processes.",
publisher = "Wiley, Hoboken",
journal = "Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques",
title = "Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome",
volume = "34",
number = "3",
pages = "371-375",
doi = "10.1111/echo.13453"
}

Petrović, M., Petrović, M., Milasinović, G., Vujisić-Tesić, B., Trifunović, D., Petrović, O., Nedeljković, I., Petrović, I., Banović, M., Boricić-Kostić, M., Petrović, J., Arena, R.,& Popović, D.. (2017). Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome. in Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
Wiley, Hoboken., 34(3), 371-375.
https://doi.org/10.1111/echo.13453

Petrović M, Petrović M, Milasinović G, Vujisić-Tesić B, Trifunović D, Petrović O, Nedeljković I, Petrović I, Banović M, Boricić-Kostić M, Petrović J, Arena R, Popović D. Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome. in Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques. 2017;34(3):371-375.
doi:10.1111/echo.13453 .

Petrović, Milan, Petrović, Marija, Milasinović, Goran, Vujisić-Tesić, Bosiljka, Trifunović, Danijela, Petrović, Olga, Nedeljković, Ivana, Petrović, Ivana, Banović, Marko, Boricić-Kostić, Marija, Petrović, Jelena, Arena, Ross, Popović, Dejana, "Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome" in Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, 34, no. 3 (2017):371-375,
https://doi.org/10.1111/echo.13453 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Damjanović, Svetozar S.
AU  - Đorđević, Tea
AU  - Martić, Dejana
AU  - Ignjatović, Svetlana
AU  - Milinković, Neda
AU  - Banović, Marko
AU  - Lasica, Ratko
AU  - Petrović, Milan
AU  - Guazzi, Marco
AU  - Arena, Ross
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2861
AB  - Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Supportive Care in Cancer
T1  - Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome
VL  - 20
IS  - 5
SP  - 523
EP  - 531
DO  - 10.1080/10253890.2017.1368488
ER  - 

@article{
author = "Popović, Dejana and Damjanović, Svetozar S. and Đorđević, Tea and Martić, Dejana and Ignjatović, Svetlana and Milinković, Neda and Banović, Marko and Lasica, Ratko and Petrović, Milan and Guazzi, Marco and Arena, Ross",
year = "2017",
abstract = "Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Supportive Care in Cancer",
title = "Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome",
volume = "20",
number = "5",
pages = "523-531",
doi = "10.1080/10253890.2017.1368488"
}

Popović, D., Damjanović, S. S., Đorđević, T., Martić, D., Ignjatović, S., Milinković, N., Banović, M., Lasica, R., Petrović, M., Guazzi, M.,& Arena, R.. (2017). Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome. in Supportive Care in Cancer
Taylor & Francis Ltd, Abingdon., 20(5), 523-531.
https://doi.org/10.1080/10253890.2017.1368488

Popović D, Damjanović SS, Đorđević T, Martić D, Ignjatović S, Milinković N, Banović M, Lasica R, Petrović M, Guazzi M, Arena R. Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome. in Supportive Care in Cancer. 2017;20(5):523-531.
doi:10.1080/10253890.2017.1368488 .

Popović, Dejana, Damjanović, Svetozar S., Đorđević, Tea, Martić, Dejana, Ignjatović, Svetlana, Milinković, Neda, Banović, Marko, Lasica, Ratko, Petrović, Milan, Guazzi, Marco, Arena, Ross, "Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome" in Supportive Care in Cancer, 20, no. 5 (2017):523-531,
https://doi.org/10.1080/10253890.2017.1368488 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Martić, Dejana
AU  - Đorđević, Tea
AU  - Pešić, Vesna
AU  - Guazzi, Marco
AU  - Myers, Jonathan
AU  - Mohebi, Reza
AU  - Arena, Ross
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2877
AB  - Background: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. Methods: 40 Caucasian patients (21.2% females), mean age 63.5 +/- 7.6 with significant coronary artery lesions (>= 50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4 days apart; subjects were subsequently followed 32 +/- 10 months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Results: Mean ejection fraction was 56.7 +/- 9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide output (Delta VCO2) recovery/peak (area under ROC curve 0.77, p = 0.02, Sn = 87.5%, Sp = 70.4%) and oxygen uptake (Delta VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p = 0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted.WMSI peak/rest on univariate analysis (p  lt  0.05). Multivariate Cox analysis revealed a high predictive value of Delta VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR = 1.27, CI = 1.07-1.51, p = 0.008). Conclusions: The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis.
PB  - Elsevier Ireland Ltd, Clare
T2  - International Journal of Cardiology
T1  - Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome
VL  - 248
SP  - 39
EP  - 45
DO  - 10.1016/j.ijcard.2017.06.107
ER  - 

@article{
author = "Popović, Dejana and Martić, Dejana and Đorđević, Tea and Pešić, Vesna and Guazzi, Marco and Myers, Jonathan and Mohebi, Reza and Arena, Ross",
year = "2017",
abstract = "Background: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. Methods: 40 Caucasian patients (21.2% females), mean age 63.5 +/- 7.6 with significant coronary artery lesions (>= 50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4 days apart; subjects were subsequently followed 32 +/- 10 months. Myocardial wall motion was recorded by echocardiography at rest and peak exercise. Ischemia was quantified by the wall motion score index (WMSI). Results: Mean ejection fraction was 56.7 +/- 9.6%. Patients with 1-2 stenotic coronary arteries (SCA) showed a poorer CPET response during the recovery phase than patients with 3-SCA. ROC analysis revealed the change of carbon-dioxide output (Delta VCO2) recovery/peak (area under ROC curve 0.77, p = 0.02, Sn = 87.5%, Sp = 70.4%) and oxygen uptake (Delta VO2) recovery/peak during TM CPET (area under ROC curve 0.76, p = 0.03, Sn 75.0%, Sp 77.8%) were significant in distinguishing between 1-2-SCA and 3-SCA. The same variables predicted.WMSI peak/rest on univariate analysis (p  lt  0.05). Multivariate Cox analysis revealed a high predictive value of Delta VO2 recovery/peak obtained during TM CPET for composite endpoint of cumulative cardiac events (HR = 1.27, CI = 1.07-1.51, p = 0.008). Conclusions: The current study suggests CPET parameters in recovery hold predictive value for CAD severity and prognosis. TM testing seems to be a better approach in the assessment of CAD severity and prognosis.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "International Journal of Cardiology",
title = "Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome",
volume = "248",
pages = "39-45",
doi = "10.1016/j.ijcard.2017.06.107"
}

Popović, D., Martić, D., Đorđević, T., Pešić, V., Guazzi, M., Myers, J., Mohebi, R.,& Arena, R.. (2017). Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome. in International Journal of Cardiology
Elsevier Ireland Ltd, Clare., 248, 39-45.
https://doi.org/10.1016/j.ijcard.2017.06.107

Popović D, Martić D, Đorđević T, Pešić V, Guazzi M, Myers J, Mohebi R, Arena R. Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome. in International Journal of Cardiology. 2017;248:39-45.
doi:10.1016/j.ijcard.2017.06.107 .

Popović, Dejana, Martić, Dejana, Đorđević, Tea, Pešić, Vesna, Guazzi, Marco, Myers, Jonathan, Mohebi, Reza, Arena, Ross, "Oxygen consumption and carbon-dioxide recovery kinetics in the prediction of coronary artery disease severity and outcome" in International Journal of Cardiology, 248 (2017):39-45,
https://doi.org/10.1016/j.ijcard.2017.06.107 . .

TY  - JOUR
AU  - Ozemek, Cemal
AU  - Phillips, Shane A.
AU  - Popović, Dejana
AU  - Laddu-Patel, Deepika
AU  - Fancher, Ibra S.
AU  - Arena, Ross
AU  - Lavie, Carl J.
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2911
AB  - Purpose of reviewNonpharmacologic lifestyle modification interventions (LMIs), such as increasing physical activity, dietary modification, weight-loss, reducing alcohol consumption and smoking cessation, are effective strategies to lower resting blood pressures (BPs) in prehypertensive or hypertensive patients. However, the limited time shared between a physician and a patient is not adequate to instill an adoption of LMI. The purpose of this review is to therefore highlight evidence-based BP lowering, LMI strategies that can feasibly be implemented in clinical practices.Recent findingsInterventions focusing on modifying physical activity, diet, weight-loss, drinking and smoking habits have established greater efficacy in reducing elevated BP compared with providing guideline recommendations based on national guidelines. Alone greater reductions in BP can be achieved through programmes that provide frequent contact time with exercise, nutrition and/or wellness professionals. Programmes that educate individuals to lead peer support groups can be an efficient method of ensuring compliance to LMI.SummaryEvidence of a multidisciplinary approach to LMI is an effective and attractive model in managing elevated BP. This strategy is an attractive model that provides the necessary patient attention to confer lifestyle maintenance.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Current Opinion in Cardiology
T1  - Nonpharmacologic management of hypertension: a multidisciplinary approach
VL  - 32
IS  - 4
SP  - 381
EP  - 388
DO  - 10.1097/HCO.0000000000000406
ER  - 

@article{
author = "Ozemek, Cemal and Phillips, Shane A. and Popović, Dejana and Laddu-Patel, Deepika and Fancher, Ibra S. and Arena, Ross and Lavie, Carl J.",
year = "2017",
abstract = "Purpose of reviewNonpharmacologic lifestyle modification interventions (LMIs), such as increasing physical activity, dietary modification, weight-loss, reducing alcohol consumption and smoking cessation, are effective strategies to lower resting blood pressures (BPs) in prehypertensive or hypertensive patients. However, the limited time shared between a physician and a patient is not adequate to instill an adoption of LMI. The purpose of this review is to therefore highlight evidence-based BP lowering, LMI strategies that can feasibly be implemented in clinical practices.Recent findingsInterventions focusing on modifying physical activity, diet, weight-loss, drinking and smoking habits have established greater efficacy in reducing elevated BP compared with providing guideline recommendations based on national guidelines. Alone greater reductions in BP can be achieved through programmes that provide frequent contact time with exercise, nutrition and/or wellness professionals. Programmes that educate individuals to lead peer support groups can be an efficient method of ensuring compliance to LMI.SummaryEvidence of a multidisciplinary approach to LMI is an effective and attractive model in managing elevated BP. This strategy is an attractive model that provides the necessary patient attention to confer lifestyle maintenance.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Current Opinion in Cardiology",
title = "Nonpharmacologic management of hypertension: a multidisciplinary approach",
volume = "32",
number = "4",
pages = "381-388",
doi = "10.1097/HCO.0000000000000406"
}

Ozemek, C., Phillips, S. A., Popović, D., Laddu-Patel, D., Fancher, I. S., Arena, R.,& Lavie, C. J.. (2017). Nonpharmacologic management of hypertension: a multidisciplinary approach. in Current Opinion in Cardiology
Lippincott Williams & Wilkins, Philadelphia., 32(4), 381-388.
https://doi.org/10.1097/HCO.0000000000000406

Ozemek C, Phillips SA, Popović D, Laddu-Patel D, Fancher IS, Arena R, Lavie CJ. Nonpharmacologic management of hypertension: a multidisciplinary approach. in Current Opinion in Cardiology. 2017;32(4):381-388.
doi:10.1097/HCO.0000000000000406 .

Ozemek, Cemal, Phillips, Shane A., Popović, Dejana, Laddu-Patel, Deepika, Fancher, Ibra S., Arena, Ross, Lavie, Carl J., "Nonpharmacologic management of hypertension: a multidisciplinary approach" in Current Opinion in Cardiology, 32, no. 4 (2017):381-388,
https://doi.org/10.1097/HCO.0000000000000406 . .

TY  - JOUR
AU  - Carbone, Salvatore
AU  - Popović, Dejana
AU  - Lavie, Carl J.
AU  - Arena, Ross
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2854
AB  - Obesity is defined as an excess body fat that impairs health and is associated with increased risk of heart failure (HF), particularly HF with preserved ejection fraction (HFpEF), evolving into a 'HFpEF obesity phenotype'. The interplay between obesity and cardiorespiratory fitness, primary clinical parameters in HF, requires further exploration. The contribution of body composition compartments in the development and progress of HF has been the object of numerous studies. Here we focus on how fat mass and lean tissues affect cardiorespiratory fitness, with emphasis on their effects on peak oxygen consumption. Moreover, while several studies have focused on characterization of body composition compartments, here we describe also recent findings related to abnormal and/or dysfunctional lean mass, especially in HFpEF.
PB  - Future Medicine Ltd, London
T2  - Future Cardiology
T1  - Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction
VL  - 13
IS  - 5
SP  - 451
EP  - 463
DO  - 10.2217/fca-2017-0023
ER  - 

@article{
author = "Carbone, Salvatore and Popović, Dejana and Lavie, Carl J. and Arena, Ross",
year = "2017",
abstract = "Obesity is defined as an excess body fat that impairs health and is associated with increased risk of heart failure (HF), particularly HF with preserved ejection fraction (HFpEF), evolving into a 'HFpEF obesity phenotype'. The interplay between obesity and cardiorespiratory fitness, primary clinical parameters in HF, requires further exploration. The contribution of body composition compartments in the development and progress of HF has been the object of numerous studies. Here we focus on how fat mass and lean tissues affect cardiorespiratory fitness, with emphasis on their effects on peak oxygen consumption. Moreover, while several studies have focused on characterization of body composition compartments, here we describe also recent findings related to abnormal and/or dysfunctional lean mass, especially in HFpEF.",
publisher = "Future Medicine Ltd, London",
journal = "Future Cardiology",
title = "Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction",
volume = "13",
number = "5",
pages = "451-463",
doi = "10.2217/fca-2017-0023"
}

Carbone, S., Popović, D., Lavie, C. J.,& Arena, R.. (2017). Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction. in Future Cardiology
Future Medicine Ltd, London., 13(5), 451-463.
https://doi.org/10.2217/fca-2017-0023

Carbone S, Popović D, Lavie CJ, Arena R. Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction. in Future Cardiology. 2017;13(5):451-463.
doi:10.2217/fca-2017-0023 .

Carbone, Salvatore, Popović, Dejana, Lavie, Carl J., Arena, Ross, "Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction" in Future Cardiology, 13, no. 5 (2017):451-463,
https://doi.org/10.2217/fca-2017-0023 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Dmitrašinović, Gordana
AU  - Plećaš-Solarović, Bosiljka
AU  - Ignjatović, Svetlana
AU  - Batinić, Bojan
AU  - Popović, Dejana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2557
AB  - Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man
DO  - 10.1155/2016/2019643
ER  - 

@article{
author = "Petrović, Jelena and Stanić, Dušanka and Dmitrašinović, Gordana and Plećaš-Solarović, Bosiljka and Ignjatović, Svetlana and Batinić, Bojan and Popović, Dejana and Pešić, Vesna",
year = "2016",
abstract = "Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man",
doi = "10.1155/2016/2019643"
}

Petrović, J., Stanić, D., Dmitrašinović, G., Plećaš-Solarović, B., Ignjatović, S., Batinić, B., Popović, D.,& Pešić, V.. (2016). Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London..
https://doi.org/10.1155/2016/2019643

Petrović J, Stanić D, Dmitrašinović G, Plećaš-Solarović B, Ignjatović S, Batinić B, Popović D, Pešić V. Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. in Oxidative Medicine and Cellular Longevity. 2016;.
doi:10.1155/2016/2019643 .

Petrović, Jelena, Stanić, Dušanka, Dmitrašinović, Gordana, Plećaš-Solarović, Bosiljka, Ignjatović, Svetlana, Batinić, Bojan, Popović, Dejana, Pešić, Vesna, "Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man" in Oxidative Medicine and Cellular Longevity (2016),
https://doi.org/10.1155/2016/2019643 . .

TY  - JOUR
AU  - Parto, Parham
AU  - Lavie, Carl J.
AU  - Arena, Ross
AU  - Bond, Samantha
AU  - Popović, Dejana
AU  - Ventura, Hector O.
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2757
AB  - The prevalence of obesity among adults and children worldwide has reached epic proportions and has become a major independent risk factor for the development of heart failure (HF), in addition to a contributor of hypertension and cardiovascular disease. The implications of obesity in the development of HF involve adverse effects on cardiac structure and function. Despite all of this, in the setting of chronic HF, excess body mass is associated with improved clinical outcomes, demonstrating the presence of an obesity paradox. In this review, we will discuss the gender differences, global application, potential mechanisms and role of interventions based on fitness and purposeful weight loss as potential therapeutic strategies.
PB  - Future Medicine Ltd, London
T2  - Future Cardiology
T1  - Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox
VL  - 12
IS  - 6
SP  - 639
EP  - 653
DO  - 10.2217/fca-2016-0029
ER  - 

@article{
author = "Parto, Parham and Lavie, Carl J. and Arena, Ross and Bond, Samantha and Popović, Dejana and Ventura, Hector O.",
year = "2016",
abstract = "The prevalence of obesity among adults and children worldwide has reached epic proportions and has become a major independent risk factor for the development of heart failure (HF), in addition to a contributor of hypertension and cardiovascular disease. The implications of obesity in the development of HF involve adverse effects on cardiac structure and function. Despite all of this, in the setting of chronic HF, excess body mass is associated with improved clinical outcomes, demonstrating the presence of an obesity paradox. In this review, we will discuss the gender differences, global application, potential mechanisms and role of interventions based on fitness and purposeful weight loss as potential therapeutic strategies.",
publisher = "Future Medicine Ltd, London",
journal = "Future Cardiology",
title = "Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox",
volume = "12",
number = "6",
pages = "639-653",
doi = "10.2217/fca-2016-0029"
}

Parto, P., Lavie, C. J., Arena, R., Bond, S., Popović, D.,& Ventura, H. O.. (2016). Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox. in Future Cardiology
Future Medicine Ltd, London., 12(6), 639-653.
https://doi.org/10.2217/fca-2016-0029

Parto P, Lavie CJ, Arena R, Bond S, Popović D, Ventura HO. Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox. in Future Cardiology. 2016;12(6):639-653.
doi:10.2217/fca-2016-0029 .

Parto, Parham, Lavie, Carl J., Arena, Ross, Bond, Samantha, Popović, Dejana, Ventura, Hector O., "Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox" in Future Cardiology, 12, no. 6 (2016):639-653,
https://doi.org/10.2217/fca-2016-0029 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Damjanović, Svetozar S.
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
AU  - Stojiljković, Stanimir
AU  - Banović, Marko
AU  - Ristić, Arsen
AU  - Mantegazza, Valentina
AU  - Agostoni, Piergiuseppe
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2619
AB  - The usage of alcohol is widespread, but the effects of acute alcohol ingestion on exercise performance and the stress hormone axis are not fully elucidated.We studied 10 healthy white men, nonhabitual drinkers, by Doppler echocardiography at rest, spirometry, and maximal cardiopulmonary exercise test (CPET) in two visits (2-4 days in between), one after administration of 1.5g/kg ethanol (whisky) diluted at 15% in water, and the other after administration of an equivalent volume of water. Plasma levels of NT-pro-BNP, cortisol, and adrenocorticotropic hormone (ACTH) were also measured 10min before the test, at maximal effort and at the third minute of recovery. Ethanol concentration was measured from resting blood samples by gas chromatography and it increased from 0.00 +/- 0.00 to 1.25 +/- 0.54 parts per thousand (P lt 0.001). Basal echocardiographic and spirometric parameters were normal and remained so after acute alcohol intake, whereas ACTH, cortisol, and NT-pro-BNP nonsignificantly increased in all phases of the test. CPET data suggested a trend toward a slight reduction of exercise performance (peak VO2=3008 +/- 638 vs. 2900 +/- 543ml/min, ns; peak workload=269 +/- 53 vs. 249 +/- 40W, ns; test duration 13.7 +/- 2.2 vs. 13.3 +/- 1.7min, ns; VE/VCO2 22.1 +/- 1.4 vs. 23.3 +/- 2.9, ns). Ventilatory equivalent for carbon dioxide at rest was higher after alcohol intake (28 +/- 2.5 vs. 30.4 +/- 3.2, P=0.039) and maximal respiratory exchange ratio was lower after alcohol intake (1.17 +/- 0.02 vs. 1.14 +/- 0.04, P=0.04). In conclusion, we showed that acute alcohol intake in healthy white men is associated with a nonsignificant exercise performance reduction and stress hormone stimulation, with an unchanged exercise metabolism.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Cardiovascular Medicine
T1  - Exercise capacity is not impaired after acute alcohol ingestion: a pilot study
VL  - 17
IS  - 12
SP  - 896
EP  - 901
DO  - 10.2459/JCM.0000000000000151
ER  - 

@article{
author = "Popović, Dejana and Damjanović, Svetozar S. and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Stojiljković, Stanimir and Banović, Marko and Ristić, Arsen and Mantegazza, Valentina and Agostoni, Piergiuseppe",
year = "2016",
abstract = "The usage of alcohol is widespread, but the effects of acute alcohol ingestion on exercise performance and the stress hormone axis are not fully elucidated.We studied 10 healthy white men, nonhabitual drinkers, by Doppler echocardiography at rest, spirometry, and maximal cardiopulmonary exercise test (CPET) in two visits (2-4 days in between), one after administration of 1.5g/kg ethanol (whisky) diluted at 15% in water, and the other after administration of an equivalent volume of water. Plasma levels of NT-pro-BNP, cortisol, and adrenocorticotropic hormone (ACTH) were also measured 10min before the test, at maximal effort and at the third minute of recovery. Ethanol concentration was measured from resting blood samples by gas chromatography and it increased from 0.00 +/- 0.00 to 1.25 +/- 0.54 parts per thousand (P lt 0.001). Basal echocardiographic and spirometric parameters were normal and remained so after acute alcohol intake, whereas ACTH, cortisol, and NT-pro-BNP nonsignificantly increased in all phases of the test. CPET data suggested a trend toward a slight reduction of exercise performance (peak VO2=3008 +/- 638 vs. 2900 +/- 543ml/min, ns; peak workload=269 +/- 53 vs. 249 +/- 40W, ns; test duration 13.7 +/- 2.2 vs. 13.3 +/- 1.7min, ns; VE/VCO2 22.1 +/- 1.4 vs. 23.3 +/- 2.9, ns). Ventilatory equivalent for carbon dioxide at rest was higher after alcohol intake (28 +/- 2.5 vs. 30.4 +/- 3.2, P=0.039) and maximal respiratory exchange ratio was lower after alcohol intake (1.17 +/- 0.02 vs. 1.14 +/- 0.04, P=0.04). In conclusion, we showed that acute alcohol intake in healthy white men is associated with a nonsignificant exercise performance reduction and stress hormone stimulation, with an unchanged exercise metabolism.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Cardiovascular Medicine",
title = "Exercise capacity is not impaired after acute alcohol ingestion: a pilot study",
volume = "17",
number = "12",
pages = "896-901",
doi = "10.2459/JCM.0000000000000151"
}

Popović, D., Damjanović, S. S., Plećaš-Solarović, B., Pešić, V., Stojiljković, S., Banović, M., Ristić, A., Mantegazza, V.,& Agostoni, P.. (2016). Exercise capacity is not impaired after acute alcohol ingestion: a pilot study. in Journal of Cardiovascular Medicine
Lippincott Williams & Wilkins, Philadelphia., 17(12), 896-901.
https://doi.org/10.2459/JCM.0000000000000151

Popović D, Damjanović SS, Plećaš-Solarović B, Pešić V, Stojiljković S, Banović M, Ristić A, Mantegazza V, Agostoni P. Exercise capacity is not impaired after acute alcohol ingestion: a pilot study. in Journal of Cardiovascular Medicine. 2016;17(12):896-901.
doi:10.2459/JCM.0000000000000151 .

Popović, Dejana, Damjanović, Svetozar S., Plećaš-Solarović, Bosiljka, Pešić, Vesna, Stojiljković, Stanimir, Banović, Marko, Ristić, Arsen, Mantegazza, Valentina, Agostoni, Piergiuseppe, "Exercise capacity is not impaired after acute alcohol ingestion: a pilot study" in Journal of Cardiovascular Medicine, 17, no. 12 (2016):896-901,
https://doi.org/10.2459/JCM.0000000000000151 . .