TY  - JOUR
AU  - Čolak, Emina
AU  - Zorić, Lepša
AU  - Radosavljević, Aleksandra
AU  - Ignjatović, Svetlana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3157
AB  - Purpose: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD. In addition, the aim was to examine the gender differences and calculate the cutoff points of tested parameters that could be associated with AMD.Material and methods: A cross-sectional study included 55 AMD patients aged 71.77.36 years and 65 aged-matched control subjects aged 70.256.46years.Results: Significantly lower ferritin (P=0.025), SOD (P=0.026), GPx (P=0.019), and TAS (P lt 0.004) values were found in patients with AMD compared to the controls (P lt 0.05). Significant association of GPx  lt  27U/gHb (odds ratio [OR]: 1.13; 95% confidence interval [CI] 0.78-2.10; P=0.049), TAS  lt  1.25mmol/L (OR: 5.77; 95% CI 0.98-367.0; P lt 0.000), ferritin  lt  84.8pg/mL (OR: 2.52; 95% CI 1.37-4.62; P=0.002), and haptoglobin lt 1.51g/L (OR: 1.94; 95% CI 1.05-3.56; P=0.031) was found with the AMD. According to receiver operating characteristic curve analysis, ferritin concentration  lt 84.8pg/L, GPx  lt  27U/gHb, and TAS  lt  1.25mmol/L have sufficient predictive ability for AMD.Conclusion: Significantly reduced capacity of the antioxidant defense system and iron-binding storage proteins (ferritin) found in AMD could have an important role in the development of increase oxidative stress in AMD patients.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Current Eye Research
T1  - The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration
VL  - 43
IS  - 5
SP  - 659
EP  - 665
DO  - 10.1080/02713683.2018.1437452
ER  - 

@article{
author = "Čolak, Emina and Zorić, Lepša and Radosavljević, Aleksandra and Ignjatović, Svetlana",
year = "2018",
abstract = "Purpose: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD. In addition, the aim was to examine the gender differences and calculate the cutoff points of tested parameters that could be associated with AMD.Material and methods: A cross-sectional study included 55 AMD patients aged 71.77.36 years and 65 aged-matched control subjects aged 70.256.46years.Results: Significantly lower ferritin (P=0.025), SOD (P=0.026), GPx (P=0.019), and TAS (P lt 0.004) values were found in patients with AMD compared to the controls (P lt 0.05). Significant association of GPx  lt  27U/gHb (odds ratio [OR]: 1.13; 95% confidence interval [CI] 0.78-2.10; P=0.049), TAS  lt  1.25mmol/L (OR: 5.77; 95% CI 0.98-367.0; P lt 0.000), ferritin  lt  84.8pg/mL (OR: 2.52; 95% CI 1.37-4.62; P=0.002), and haptoglobin lt 1.51g/L (OR: 1.94; 95% CI 1.05-3.56; P=0.031) was found with the AMD. According to receiver operating characteristic curve analysis, ferritin concentration  lt 84.8pg/L, GPx  lt  27U/gHb, and TAS  lt  1.25mmol/L have sufficient predictive ability for AMD.Conclusion: Significantly reduced capacity of the antioxidant defense system and iron-binding storage proteins (ferritin) found in AMD could have an important role in the development of increase oxidative stress in AMD patients.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Current Eye Research",
title = "The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration",
volume = "43",
number = "5",
pages = "659-665",
doi = "10.1080/02713683.2018.1437452"
}

Čolak, E., Zorić, L., Radosavljević, A.,& Ignjatović, S.. (2018). The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration. in Current Eye Research
Taylor & Francis Inc, Philadelphia., 43(5), 659-665.
https://doi.org/10.1080/02713683.2018.1437452

Čolak E, Zorić L, Radosavljević A, Ignjatović S. The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration. in Current Eye Research. 2018;43(5):659-665.
doi:10.1080/02713683.2018.1437452 .

Čolak, Emina, Zorić, Lepša, Radosavljević, Aleksandra, Ignjatović, Svetlana, "The Association of Serum Iron-Binding Proteins and the Antioxidant Parameter Levels in Age-Related Macular Degeneration" in Current Eye Research, 43, no. 5 (2018):659-665,
https://doi.org/10.1080/02713683.2018.1437452 . .

TY  - JOUR
AU  - Colak, Emina
AU  - Ignjatović, Svetlana
AU  - Radosavljević, Aleksandra
AU  - Zorić, Lepsa
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3011
AB  - There are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p lt 0.05). Significant negative correlations were found between GPx and fibrinogen (r = -0.254), TAS and IL-6 (r = -0.999) and positive correlations between uric acid and CRP (r = 0.292), IL-6 and uric acid (r = 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32, p = 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85, p = 0.021), TAS (OR: 7.45, 95% CI: 3.97-14.35, p = 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41, p = 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02, p = 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.
PB  - Journal Clinical Biochemistry & Nutrition, Kyoto
T2  - Journal of Clinical Biochemistry and Nutrition
T1  - The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration
VL  - 60
IS  - 2
SP  - 100
EP  - 107
DO  - 10.3164/jcbn.16-30
ER  - 

@article{
author = "Colak, Emina and Ignjatović, Svetlana and Radosavljević, Aleksandra and Zorić, Lepsa",
year = "2017",
abstract = "There are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p lt 0.05). Significant negative correlations were found between GPx and fibrinogen (r = -0.254), TAS and IL-6 (r = -0.999) and positive correlations between uric acid and CRP (r = 0.292), IL-6 and uric acid (r = 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32, p = 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85, p = 0.021), TAS (OR: 7.45, 95% CI: 3.97-14.35, p = 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41, p = 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02, p = 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.",
publisher = "Journal Clinical Biochemistry & Nutrition, Kyoto",
journal = "Journal of Clinical Biochemistry and Nutrition",
title = "The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration",
volume = "60",
number = "2",
pages = "100-107",
doi = "10.3164/jcbn.16-30"
}

Colak, E., Ignjatović, S., Radosavljević, A.,& Zorić, L.. (2017). The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration. in Journal of Clinical Biochemistry and Nutrition
Journal Clinical Biochemistry & Nutrition, Kyoto., 60(2), 100-107.
https://doi.org/10.3164/jcbn.16-30

Colak E, Ignjatović S, Radosavljević A, Zorić L. The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration. in Journal of Clinical Biochemistry and Nutrition. 2017;60(2):100-107.
doi:10.3164/jcbn.16-30 .

Colak, Emina, Ignjatović, Svetlana, Radosavljević, Aleksandra, Zorić, Lepsa, "The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration" in Journal of Clinical Biochemistry and Nutrition, 60, no. 2 (2017):100-107,
https://doi.org/10.3164/jcbn.16-30 . .