TY  - JOUR
AU  - Tešić, Milorad
AU  - Travica, Lazar
AU  - Giga, Vojislav
AU  - Jovanović, Ivana
AU  - Trifunović-Zamaklar, Danijela
AU  - Popović, Dejana
AU  - Mladenović, Đorđe
AU  - Radomirović, Marija
AU  - Vratonjić, Jelena
AU  - Bošković, Nikola
AU  - Dedić, Srđan
AU  - Nedeljković Arsenović, Olga
AU  - Aleksandrić, Srđan
AU  - Juričić, Stefan
AU  - Beleslin, Branko
AU  - Đorđević Dikić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5203
AB  - Background and Objectives: Mitral valve pathology and mitral regurgitation (MR) are very common in patients with hypertrophic cardiomyopathy (HCM), and the evaluation of mitral valve anatomy and degree of MR is important in patients with HCM. The aim of our study was to examine the potential influence of moderate or moderately severe MR on the prognosis, clinical presentation, and structural characteristics of HCM patients. Materials and Methods: A prospective study examined 176 patients diagnosed with primary asymmetric HCM. According to the severity of the MR, the patients were divided into two groups: Group 1 (n = 116) with no/trace or mild MR and Group 2 (n = 60) with moderate or moderately severe MR. All patients had clinical and echocardiographic examinations, as well as a 24 h Holter ECG. Results: Group 2 had significantly more often the presence of the obstructive type of HCM (p < 0.001), syncope (p = 0.030), NYHA II class (p < 0.001), and atrial fibrillation (p = 0.023). Also, Group 2 had an enlarged left atrial dimension (p < 0.001), left atrial volume index (p < 0.001), and indirectly measured systolic pressure in the right ventricle (p < 0.001). Patients with a higher grade of MR had a significantly higher E/e' (p < 0.001) and, as a result, higher values of Nt pro BNP values (p < 0.001) compared to Group 1. Kaplan-Meier analysis demonstrated that the event-free survival rate during a median follow-up of 88 (IQR 40-112) months was significantly higher in Group 1 compared to Group 2 (84% vs. 45% at 8 years; log-rank 20.4, p < 0.001). After adjustment for relevant confounders, the presence of moderate or moderately severe MR remained as an independent predictor of adverse outcomes (HR 2.788; 95% CI 1.221-6.364, p = 0.015). Conclusions: The presence of moderate or moderately severe MR was associated with unfavorable long-term outcomes in HCM patients.
PB  - MDPI
T2  - Medicina (Kaunas, Lithuania)
T1  - Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy
VL  - 59
IS  - 10
DO  - 10.3390/medicina59101798
ER  - 

@article{
author = "Tešić, Milorad and Travica, Lazar and Giga, Vojislav and Jovanović, Ivana and Trifunović-Zamaklar, Danijela and Popović, Dejana and Mladenović, Đorđe and Radomirović, Marija and Vratonjić, Jelena and Bošković, Nikola and Dedić, Srđan and Nedeljković Arsenović, Olga and Aleksandrić, Srđan and Juričić, Stefan and Beleslin, Branko and Đorđević Dikić, Ana",
year = "2023",
abstract = "Background and Objectives: Mitral valve pathology and mitral regurgitation (MR) are very common in patients with hypertrophic cardiomyopathy (HCM), and the evaluation of mitral valve anatomy and degree of MR is important in patients with HCM. The aim of our study was to examine the potential influence of moderate or moderately severe MR on the prognosis, clinical presentation, and structural characteristics of HCM patients. Materials and Methods: A prospective study examined 176 patients diagnosed with primary asymmetric HCM. According to the severity of the MR, the patients were divided into two groups: Group 1 (n = 116) with no/trace or mild MR and Group 2 (n = 60) with moderate or moderately severe MR. All patients had clinical and echocardiographic examinations, as well as a 24 h Holter ECG. Results: Group 2 had significantly more often the presence of the obstructive type of HCM (p < 0.001), syncope (p = 0.030), NYHA II class (p < 0.001), and atrial fibrillation (p = 0.023). Also, Group 2 had an enlarged left atrial dimension (p < 0.001), left atrial volume index (p < 0.001), and indirectly measured systolic pressure in the right ventricle (p < 0.001). Patients with a higher grade of MR had a significantly higher E/e' (p < 0.001) and, as a result, higher values of Nt pro BNP values (p < 0.001) compared to Group 1. Kaplan-Meier analysis demonstrated that the event-free survival rate during a median follow-up of 88 (IQR 40-112) months was significantly higher in Group 1 compared to Group 2 (84% vs. 45% at 8 years; log-rank 20.4, p < 0.001). After adjustment for relevant confounders, the presence of moderate or moderately severe MR remained as an independent predictor of adverse outcomes (HR 2.788; 95% CI 1.221-6.364, p = 0.015). Conclusions: The presence of moderate or moderately severe MR was associated with unfavorable long-term outcomes in HCM patients.",
publisher = "MDPI",
journal = "Medicina (Kaunas, Lithuania)",
title = "Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy",
volume = "59",
number = "10",
doi = "10.3390/medicina59101798"
}

Tešić, M., Travica, L., Giga, V., Jovanović, I., Trifunović-Zamaklar, D., Popović, D., Mladenović, Đ., Radomirović, M., Vratonjić, J., Bošković, N., Dedić, S., Nedeljković Arsenović, O., Aleksandrić, S., Juričić, S., Beleslin, B.,& Đorđević Dikić, A.. (2023). Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy. in Medicina (Kaunas, Lithuania)
MDPI., 59(10).
https://doi.org/10.3390/medicina59101798

Tešić M, Travica L, Giga V, Jovanović I, Trifunović-Zamaklar D, Popović D, Mladenović Đ, Radomirović M, Vratonjić J, Bošković N, Dedić S, Nedeljković Arsenović O, Aleksandrić S, Juričić S, Beleslin B, Đorđević Dikić A. Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy. in Medicina (Kaunas, Lithuania). 2023;59(10).
doi:10.3390/medicina59101798 .

Tešić, Milorad, Travica, Lazar, Giga, Vojislav, Jovanović, Ivana, Trifunović-Zamaklar, Danijela, Popović, Dejana, Mladenović, Đorđe, Radomirović, Marija, Vratonjić, Jelena, Bošković, Nikola, Dedić, Srđan, Nedeljković Arsenović, Olga, Aleksandrić, Srđan, Juričić, Stefan, Beleslin, Branko, Đorđević Dikić, Ana, "Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy" in Medicina (Kaunas, Lithuania), 59, no. 10 (2023),
https://doi.org/10.3390/medicina59101798 . .

TY  - CONF
AU  - Marčetić, Mirjana
AU  - Škobić, Slađana
AU  - Radović, Jelena
AU  - Bošković, Nikola
AU  - Damjanović, Anđela
AU  - Kundaković, Tatjana
AU  - Crnobarac, Jovan
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5272
AB  - Sweet flag rhizome (Acorus calamus L., Acoraceae) possesses various biological activities such as sedative, anticonvulsant, immunosuppressant, antidiabetic, antiinflammatory etc. [1]. The aim was to study the content and composition of essential oils from 24 rhizome samples of the cultivated sweet flag, their comparison with the samples from 5 natural habitats, and the influence of nitrogen fertilization on the composition of essential oils. Essential oils were analyzed using GC and GC/MS. Statistical analysis included the analysis of variance and cluster analysis. The content of essential oil was not significantly different between the samples from natural habitats (0.8-1.1%) and cultures (0.3-2.2%). All samples contained dominant oxygenated sesquiterpenes (24.5-32.6%), phenylpropanoids (5.7-22.5%), and oxygenated monoterpenes (4.4-19.2%). The main components were β-asarone (10.4-21.4%), camphor (3.5-15.2%), acorenone (9.3-14.1%) and cyperotudone (7.3-11.0%). The contents of β-asarone and aristolone were significantly higher (p<0.05) in cultivated plants. The nitrogen fertilization during the cultivation did not have a significant influence (p<0.05) on the content and composition of the essential oils.
PB  - University of Niš, Serbia
C3  - Facta Universitatis, Series: Physics, Chemistry and Technology: 49th International Symposium on Essential Oils (ISEO2018), Book of Abstracts
T1  - The composition of the essential oils of Acorus calamus L. rhizomes from different habitats
VL  - 16
IS  - 1 Special issue
SP  - 105
EP  - 105
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5272
ER  - 

@conference{
author = "Marčetić, Mirjana and Škobić, Slađana and Radović, Jelena and Bošković, Nikola and Damjanović, Anđela and Kundaković, Tatjana and Crnobarac, Jovan",
year = "2018",
abstract = "Sweet flag rhizome (Acorus calamus L., Acoraceae) possesses various biological activities such as sedative, anticonvulsant, immunosuppressant, antidiabetic, antiinflammatory etc. [1]. The aim was to study the content and composition of essential oils from 24 rhizome samples of the cultivated sweet flag, their comparison with the samples from 5 natural habitats, and the influence of nitrogen fertilization on the composition of essential oils. Essential oils were analyzed using GC and GC/MS. Statistical analysis included the analysis of variance and cluster analysis. The content of essential oil was not significantly different between the samples from natural habitats (0.8-1.1%) and cultures (0.3-2.2%). All samples contained dominant oxygenated sesquiterpenes (24.5-32.6%), phenylpropanoids (5.7-22.5%), and oxygenated monoterpenes (4.4-19.2%). The main components were β-asarone (10.4-21.4%), camphor (3.5-15.2%), acorenone (9.3-14.1%) and cyperotudone (7.3-11.0%). The contents of β-asarone and aristolone were significantly higher (p<0.05) in cultivated plants. The nitrogen fertilization during the cultivation did not have a significant influence (p<0.05) on the content and composition of the essential oils.",
publisher = "University of Niš, Serbia",
journal = "Facta Universitatis, Series: Physics, Chemistry and Technology: 49th International Symposium on Essential Oils (ISEO2018), Book of Abstracts",
title = "The composition of the essential oils of Acorus calamus L. rhizomes from different habitats",
volume = "16",
number = "1 Special issue",
pages = "105-105",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5272"
}

Marčetić, M., Škobić, S., Radović, J., Bošković, N., Damjanović, A., Kundaković, T.,& Crnobarac, J.. (2018). The composition of the essential oils of Acorus calamus L. rhizomes from different habitats. in Facta Universitatis, Series: Physics, Chemistry and Technology: 49th International Symposium on Essential Oils (ISEO2018), Book of Abstracts
University of Niš, Serbia., 16(1 Special issue), 105-105.
https://hdl.handle.net/21.15107/rcub_farfar_5272

Marčetić M, Škobić S, Radović J, Bošković N, Damjanović A, Kundaković T, Crnobarac J. The composition of the essential oils of Acorus calamus L. rhizomes from different habitats. in Facta Universitatis, Series: Physics, Chemistry and Technology: 49th International Symposium on Essential Oils (ISEO2018), Book of Abstracts. 2018;16(1 Special issue):105-105.
https://hdl.handle.net/21.15107/rcub_farfar_5272 .

Marčetić, Mirjana, Škobić, Slađana, Radović, Jelena, Bošković, Nikola, Damjanović, Anđela, Kundaković, Tatjana, Crnobarac, Jovan, "The composition of the essential oils of Acorus calamus L. rhizomes from different habitats" in Facta Universitatis, Series: Physics, Chemistry and Technology: 49th International Symposium on Essential Oils (ISEO2018), Book of Abstracts, 16, no. 1 Special issue (2018):105-105,
https://hdl.handle.net/21.15107/rcub_farfar_5272 .

TY  - CONF
AU  - Marčetić, Mirjana
AU  - Bošković, Nikola
AU  - Stojanović, Danilo
AU  - Kovačević, Nada
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5283
AB  - Tradicionalno list matičnjaka, Melissae folium, koristi se za ublažavanje blagih
simptoma mentalnog stresa i olakšavanje uspavljivanja, kao i u simptomatskoj terapiji
blagih gastrointestinalnih poremećaja. Etarsko ulje matičnjaka je veoma cenjeno u
prehrambenoj i kozmetičkoj industriji. Cilj rada je bio ispitivanje makroskopskih i
mikroskopskih osobina uzoraka lista samoniklog i gajenog matičnjaka sa različitih
lokaliteta i komercijalno dostupnih čajeva, kao i ispitivanja sastava njihovih etarskih
ulja.
Za analizu etarskih ulja (16 uzoraka), dobijenih destilacijom vodenom parom,
primenjena je gasna hromatografija (GC‐FID) i gasna hromatografija sa masenom
spektrometrijom (GC‐MS). Klaster analizom ispitivane su razlike između etarskih ulja.
Makroskopske i mikroskopske odlike svih uzoraka su odgovarale monografiji
Melissae folium u Ph. Eur. 7.0, ali je u 2 od 5 komercijalnih uzoraka bio veći sadržaj
stranih materija. U svim ispitivanim etarskim uljima glavne komponenate su
predstavljali: geranial (15,58‐53,33%), neral (10,73‐36,64 %), kariofilen oksid (0,76‐
35,57 %), (E)‐kariofilen (tragovi‐16,72 %) i citronelal (0,00‐12,64 %). Sadržaj geraniala
i nerala u ispitivanim uzorcima je bio u opsegu vrednosti dobijenih u prethodnim
ispitivanjima.
Klaster analizom uzorci etarskog ulja su podeljeni na dva klastera. U prvom
klasteru su bila etarska ulja sa visokim sadržajem geraniala i nerala (31,87‐53,33% i
19,81‐36,64%): etarska ulja lista i herbe samoniklog i gajenog matičnjaka u različitim
fazama razvoja i sa različitih lokaliteta i dva komercijalna uzorka. U drugi klaster su
svrstana etarska ulja sa nižim sadržajem geraniala i nerala (15,58‐26,67 % i 10,73‐
15,48 %) i većim udelom kariofilen‐oksida (17,79‐35,57 %): tri komercijalna uzorka i
etarsko ulje herbe. List samoniklog matičnjaka u različitim fazama razvoja, sadrži visok
procenat geraniala i nerala u etarskom ulju, ne razlikuje se značajno od gajenih uzoraka
i može predstavljati izvor kvalitetne droge.
AB  - Traditional herbal remedies based on lemon balm leaf, Melissae folium are used
for relief of mild symptoms of mental stress, to aid sleep and for symptomatic
treatment of mild gastrointestinal complaints. The essential oil of lemon balm is very
appreciated in food and cosmetic industry. The aim was to examine the macroscopic
and microscopic characteristics of lemon balm leaves of cultivated and wild plants from
different localities, commercially available tea samples and to determinate the
composition of their essential oils. The essential oils obtained by hydrodistillation (16
samples), were analysed by gas chromatography (GC‐FID) and gas chromatography
with mass spectrometry (GC‐MS). The differences between essential oils were
examined by cluster analysis.
Macroscopic and microscopic characteristics corresponded to the monograph
Melissae folium in Ph. Eur. 7.0, while 2 of 5 commercial samples contained higher
content of foreign matter.
The main components in investigated essential oils were: geranial (15.58‐53.33
%), neral (10.73‐36.64 %), caryophyllene oxide (0.76‐35.57 %), (E)‐caryophyllene
(traces‐16.72 %) and citronellal (0.00‐12.64 %). The content of geranial and neral was
in the range of values obtained in previous investigations.
Cluster analysis divided samples of essential oils into two clusters. Essential oils
with high geranial and neral content (31.87‐53.33 % and 19.81‐36.64 %) were in the
first cluster: essential oils of leaf and aerial parts of wild and cultivated lemon balm
from different development phases and localities and two commercial samples. The
essential oils with lower geranial and neral content (15.58‐26.67 % and 10.73‐15.48 %)
and higher caryophyllene oxide (17.79‐35.57 %) were separated to the second cluster:
three commercial samples and essential oil of aerial parts.The wild lemon balm leaf in
different phases of development contains essential oil with high amounts of geranial
and neral. It is not significantly different from cultivated samples and could represent a
source of quality herbal substance.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Ispitivanje makroskopskih, mikroskopskih osobina i etarskog ulja lista matičnjaka, Melissa officinalis L.
T1  - Investigation of macroscopic and microscopic characteristics and essential oil of the lemon balm leaf, Melissa officinalis L.
VL  - 68
IS  - 3
SP  - 698
EP  - 699
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5283
ER  - 

@conference{
author = "Marčetić, Mirjana and Bošković, Nikola and Stojanović, Danilo and Kovačević, Nada",
year = "2018",
abstract = "Tradicionalno list matičnjaka, Melissae folium, koristi se za ublažavanje blagih
simptoma mentalnog stresa i olakšavanje uspavljivanja, kao i u simptomatskoj terapiji
blagih gastrointestinalnih poremećaja. Etarsko ulje matičnjaka je veoma cenjeno u
prehrambenoj i kozmetičkoj industriji. Cilj rada je bio ispitivanje makroskopskih i
mikroskopskih osobina uzoraka lista samoniklog i gajenog matičnjaka sa različitih
lokaliteta i komercijalno dostupnih čajeva, kao i ispitivanja sastava njihovih etarskih
ulja.
Za analizu etarskih ulja (16 uzoraka), dobijenih destilacijom vodenom parom,
primenjena je gasna hromatografija (GC‐FID) i gasna hromatografija sa masenom
spektrometrijom (GC‐MS). Klaster analizom ispitivane su razlike između etarskih ulja.
Makroskopske i mikroskopske odlike svih uzoraka su odgovarale monografiji
Melissae folium u Ph. Eur. 7.0, ali je u 2 od 5 komercijalnih uzoraka bio veći sadržaj
stranih materija. U svim ispitivanim etarskim uljima glavne komponenate su
predstavljali: geranial (15,58‐53,33%), neral (10,73‐36,64 %), kariofilen oksid (0,76‐
35,57 %), (E)‐kariofilen (tragovi‐16,72 %) i citronelal (0,00‐12,64 %). Sadržaj geraniala
i nerala u ispitivanim uzorcima je bio u opsegu vrednosti dobijenih u prethodnim
ispitivanjima.
Klaster analizom uzorci etarskog ulja su podeljeni na dva klastera. U prvom
klasteru su bila etarska ulja sa visokim sadržajem geraniala i nerala (31,87‐53,33% i
19,81‐36,64%): etarska ulja lista i herbe samoniklog i gajenog matičnjaka u različitim
fazama razvoja i sa različitih lokaliteta i dva komercijalna uzorka. U drugi klaster su
svrstana etarska ulja sa nižim sadržajem geraniala i nerala (15,58‐26,67 % i 10,73‐
15,48 %) i većim udelom kariofilen‐oksida (17,79‐35,57 %): tri komercijalna uzorka i
etarsko ulje herbe. List samoniklog matičnjaka u različitim fazama razvoja, sadrži visok
procenat geraniala i nerala u etarskom ulju, ne razlikuje se značajno od gajenih uzoraka
i može predstavljati izvor kvalitetne droge., Traditional herbal remedies based on lemon balm leaf, Melissae folium are used
for relief of mild symptoms of mental stress, to aid sleep and for symptomatic
treatment of mild gastrointestinal complaints. The essential oil of lemon balm is very
appreciated in food and cosmetic industry. The aim was to examine the macroscopic
and microscopic characteristics of lemon balm leaves of cultivated and wild plants from
different localities, commercially available tea samples and to determinate the
composition of their essential oils. The essential oils obtained by hydrodistillation (16
samples), were analysed by gas chromatography (GC‐FID) and gas chromatography
with mass spectrometry (GC‐MS). The differences between essential oils were
examined by cluster analysis.
Macroscopic and microscopic characteristics corresponded to the monograph
Melissae folium in Ph. Eur. 7.0, while 2 of 5 commercial samples contained higher
content of foreign matter.
The main components in investigated essential oils were: geranial (15.58‐53.33
%), neral (10.73‐36.64 %), caryophyllene oxide (0.76‐35.57 %), (E)‐caryophyllene
(traces‐16.72 %) and citronellal (0.00‐12.64 %). The content of geranial and neral was
in the range of values obtained in previous investigations.
Cluster analysis divided samples of essential oils into two clusters. Essential oils
with high geranial and neral content (31.87‐53.33 % and 19.81‐36.64 %) were in the
first cluster: essential oils of leaf and aerial parts of wild and cultivated lemon balm
from different development phases and localities and two commercial samples. The
essential oils with lower geranial and neral content (15.58‐26.67 % and 10.73‐15.48 %)
and higher caryophyllene oxide (17.79‐35.57 %) were separated to the second cluster:
three commercial samples and essential oil of aerial parts.The wild lemon balm leaf in
different phases of development contains essential oil with high amounts of geranial
and neral. It is not significantly different from cultivated samples and could represent a
source of quality herbal substance.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Ispitivanje makroskopskih, mikroskopskih osobina i etarskog ulja lista matičnjaka, Melissa officinalis L., Investigation of macroscopic and microscopic characteristics and essential oil of the lemon balm leaf, Melissa officinalis L.",
volume = "68",
number = "3",
pages = "698-699",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5283"
}

Marčetić, M., Bošković, N., Stojanović, D.,& Kovačević, N.. (2018). Ispitivanje makroskopskih, mikroskopskih osobina i etarskog ulja lista matičnjaka, Melissa officinalis L.. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 68(3), 698-699.
https://hdl.handle.net/21.15107/rcub_farfar_5283

Marčetić M, Bošković N, Stojanović D, Kovačević N. Ispitivanje makroskopskih, mikroskopskih osobina i etarskog ulja lista matičnjaka, Melissa officinalis L.. in Arhiv za farmaciju. 2018;68(3):698-699.
https://hdl.handle.net/21.15107/rcub_farfar_5283 .

Marčetić, Mirjana, Bošković, Nikola, Stojanović, Danilo, Kovačević, Nada, "Ispitivanje makroskopskih, mikroskopskih osobina i etarskog ulja lista matičnjaka, Melissa officinalis L." in Arhiv za farmaciju, 68, no. 3 (2018):698-699,
https://hdl.handle.net/21.15107/rcub_farfar_5283 .