TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Giglio, Rosaria Vincenza
AU  - Ciaccio, Marcello
AU  - Rizzo, Manfredi
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3992
AB  - Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical studies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be a promising strategy in reducing the incidence of CRC in patients with diabetes. However, available findings are inconclusive, and further studies are required. In this review, novel evidence on molecular mechanisms linking T2DM with CRC development, progression, and survival will be discussed. In addition, the potential role of GLP-1RAs therapies in CRC prevention will also be evaluated.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents
VL  - 22
IS  - 22
DO  - 10.3390/ijms222212409
ER  - 

@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Giglio, Rosaria Vincenza and Ciaccio, Marcello and Rizzo, Manfredi",
year = "2021",
abstract = "Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical studies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be a promising strategy in reducing the incidence of CRC in patients with diabetes. However, available findings are inconclusive, and further studies are required. In this review, novel evidence on molecular mechanisms linking T2DM with CRC development, progression, and survival will be discussed. In addition, the potential role of GLP-1RAs therapies in CRC prevention will also be evaluated.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents",
volume = "22",
number = "22",
doi = "10.3390/ijms222212409"
}

Vekić, J., Zeljković, A., Stefanović, A., Giglio, R. V., Ciaccio, M.,& Rizzo, M.. (2021). Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents. in International Journal of Molecular Sciences
MDPI., 22(22).
https://doi.org/10.3390/ijms222212409

Vekić J, Zeljković A, Stefanović A, Giglio RV, Ciaccio M, Rizzo M. Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents. in International Journal of Molecular Sciences. 2021;22(22).
doi:10.3390/ijms222212409 .

Vekić, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Giglio, Rosaria Vincenza, Ciaccio, Marcello, Rizzo, Manfredi, "Diabetes and colorectal cancer risk: A new look at molecular mechanisms and potential role of novel antidiabetic agents" in International Journal of Molecular Sciences, 22, no. 22 (2021),
https://doi.org/10.3390/ijms222212409 . .