TY  - JOUR
AU  - Vekić, Jelena
AU  - Joppa, Pavol
AU  - Habalova, Viera
AU  - Tisko, Radovan
AU  - Zeljković, Aleksandra
AU  - Pobeha, Pavol
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Strbova, Zuzana
AU  - Kuklisova, Zuzana
AU  - Slaba, Eva
AU  - Rizzo, Manfredi
AU  - Tkacova, Ruzena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2765
AB  - Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P  lt  .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P  lt  .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Angiology
T1  - Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea
VL  - 67
IS  - 10
SP  - 937
EP  - 944
DO  - 10.1177/0003319716636512
ER  - 

@article{
author = "Vekić, Jelena and Joppa, Pavol and Habalova, Viera and Tisko, Radovan and Zeljković, Aleksandra and Pobeha, Pavol and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Strbova, Zuzana and Kuklisova, Zuzana and Slaba, Eva and Rizzo, Manfredi and Tkacova, Ruzena",
year = "2016",
abstract = "Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P  lt  .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P  lt  .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Angiology",
title = "Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea",
volume = "67",
number = "10",
pages = "937-944",
doi = "10.1177/0003319716636512"
}

Vekić, J., Joppa, P., Habalova, V., Tisko, R., Zeljković, A., Pobeha, P., Gojković, T., Spasojević-Kalimanovska, V., Strbova, Z., Kuklisova, Z., Slaba, E., Rizzo, M.,& Tkacova, R.. (2016). Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea. in Angiology
Sage Publications Inc, Thousand Oaks., 67(10), 937-944.
https://doi.org/10.1177/0003319716636512

Vekić J, Joppa P, Habalova V, Tisko R, Zeljković A, Pobeha P, Gojković T, Spasojević-Kalimanovska V, Strbova Z, Kuklisova Z, Slaba E, Rizzo M, Tkacova R. Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea. in Angiology. 2016;67(10):937-944.
doi:10.1177/0003319716636512 .

Vekić, Jelena, Joppa, Pavol, Habalova, Viera, Tisko, Radovan, Zeljković, Aleksandra, Pobeha, Pavol, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Strbova, Zuzana, Kuklisova, Zuzana, Slaba, Eva, Rizzo, Manfredi, Tkacova, Ruzena, "Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea" in Angiology, 67, no. 10 (2016):937-944,
https://doi.org/10.1177/0003319716636512 . .

TY  - CONF
AU  - Tisko, Radovan
AU  - Jelić-Ivanović, Zorana
AU  - Habalova, Viera
AU  - Sopkova, Zuzana
AU  - Slaba, Eva
AU  - Vekić, Jelena
AU  - Dorkova, Zuzana
AU  - Zeljković, Aleksandra
AU  - Joppa, Pavol
AU  - Rizzo, Manfredi
AU  - Tkacova, Ruzena
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1886
PB  - European Respiratory Soc Journals Ltd, Sheffield
C3  - European Respiratory Journal
T1  - Predictors of lipoprotein particle size and subclasses in patients with OSA
VL  - 42
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1886
ER  - 

@conference{
author = "Tisko, Radovan and Jelić-Ivanović, Zorana and Habalova, Viera and Sopkova, Zuzana and Slaba, Eva and Vekić, Jelena and Dorkova, Zuzana and Zeljković, Aleksandra and Joppa, Pavol and Rizzo, Manfredi and Tkacova, Ruzena",
year = "2013",
publisher = "European Respiratory Soc Journals Ltd, Sheffield",
journal = "European Respiratory Journal",
title = "Predictors of lipoprotein particle size and subclasses in patients with OSA",
volume = "42",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1886"
}

Tisko, R., Jelić-Ivanović, Z., Habalova, V., Sopkova, Z., Slaba, E., Vekić, J., Dorkova, Z., Zeljković, A., Joppa, P., Rizzo, M.,& Tkacova, R.. (2013). Predictors of lipoprotein particle size and subclasses in patients with OSA. in European Respiratory Journal
European Respiratory Soc Journals Ltd, Sheffield., 42.
https://hdl.handle.net/21.15107/rcub_farfar_1886

Tisko R, Jelić-Ivanović Z, Habalova V, Sopkova Z, Slaba E, Vekić J, Dorkova Z, Zeljković A, Joppa P, Rizzo M, Tkacova R. Predictors of lipoprotein particle size and subclasses in patients with OSA. in European Respiratory Journal. 2013;42.
https://hdl.handle.net/21.15107/rcub_farfar_1886 .

Tisko, Radovan, Jelić-Ivanović, Zorana, Habalova, Viera, Sopkova, Zuzana, Slaba, Eva, Vekić, Jelena, Dorkova, Zuzana, Zeljković, Aleksandra, Joppa, Pavol, Rizzo, Manfredi, Tkacova, Ruzena, "Predictors of lipoprotein particle size and subclasses in patients with OSA" in European Respiratory Journal, 42 (2013),
https://hdl.handle.net/21.15107/rcub_farfar_1886 .