TY  - JOUR
AU  - Ivanišević, Ivana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1995
AB  - Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - L-FABP can be an early marker of acute kidney injury in children
VL  - 28
IS  - 6
SP  - 963
EP  - 969
DO  - 10.1007/s00467-013-2421-z
ER  - 

@article{
author = "Ivanišević, Ivana and Peco-Antić, Amira and Vulicević, Irena and Hercog, Đorđe and Milovanović, Vladimir and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Kocev, Nikola",
year = "2013",
abstract = "Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "L-FABP can be an early marker of acute kidney injury in children",
volume = "28",
number = "6",
pages = "963-969",
doi = "10.1007/s00467-013-2421-z"
}

Ivanišević, I., Peco-Antić, A., Vulicević, I., Hercog, Đ., Milovanović, V., Kotur-Stevuljević, J., Stefanović, A.,& Kocev, N.. (2013). L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology
Springer, New York., 28(6), 963-969.
https://doi.org/10.1007/s00467-013-2421-z

Ivanišević I, Peco-Antić A, Vulicević I, Hercog Đ, Milovanović V, Kotur-Stevuljević J, Stefanović A, Kocev N. L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology. 2013;28(6):963-969.
doi:10.1007/s00467-013-2421-z .

Ivanišević, Ivana, Peco-Antić, Amira, Vulicević, Irena, Hercog, Đorđe, Milovanović, Vladimir, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Kocev, Nikola, "L-FABP can be an early marker of acute kidney injury in children" in Pediatric Nephrology, 28, no. 6 (2013):963-969,
https://doi.org/10.1007/s00467-013-2421-z . .

TY  - CONF
AU  - Peco-Antić, Amira
AU  - Vukicević, Irena
AU  - Kotur, Jelena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Ivanišević, Jasmina
AU  - Ivanišević, Ivana
AU  - Miljković, Milica
AU  - Kocev, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1741
PB  - Springer, New York
C3  - Pediatric Nephrology
T1  - Biomarkers of acute kidney injury in pediatric cardiac surgery
VL  - 27
IS  - 9
SP  - 1620
EP  - 1620
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1741
ER  - 

@conference{
author = "Peco-Antić, Amira and Vukicević, Irena and Kotur, Jelena and Hercog, Đorđe and Milovanović, Vladimir and Ivanišević, Jasmina and Ivanišević, Ivana and Miljković, Milica and Kocev, Nikola",
year = "2012",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Biomarkers of acute kidney injury in pediatric cardiac surgery",
volume = "27",
number = "9",
pages = "1620-1620",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1741"
}

Peco-Antić, A., Vukicević, I., Kotur, J., Hercog, Đ., Milovanović, V., Ivanišević, J., Ivanišević, I., Miljković, M.,& Kocev, N.. (2012). Biomarkers of acute kidney injury in pediatric cardiac surgery. in Pediatric Nephrology
Springer, New York., 27(9), 1620-1620.
https://hdl.handle.net/21.15107/rcub_farfar_1741

Peco-Antić A, Vukicević I, Kotur J, Hercog Đ, Milovanović V, Ivanišević J, Ivanišević I, Miljković M, Kocev N. Biomarkers of acute kidney injury in pediatric cardiac surgery. in Pediatric Nephrology. 2012;27(9):1620-1620.
https://hdl.handle.net/21.15107/rcub_farfar_1741 .

Peco-Antić, Amira, Vukicević, Irena, Kotur, Jelena, Hercog, Đorđe, Milovanović, Vladimir, Ivanišević, Jasmina, Ivanišević, Ivana, Miljković, Milica, Kocev, Nikola, "Biomarkers of acute kidney injury in pediatric cardiac surgery" in Pediatric Nephrology, 27, no. 9 (2012):1620-1620,
https://hdl.handle.net/21.15107/rcub_farfar_1741 .