TY  - JOUR
AU  - Martinović, Jelena
AU  - Samardžić, Janko
AU  - Zarić Kontić, Marina
AU  - Ivković, Sanja
AU  - Dacić, Sanja
AU  - Major, Tamara
AU  - Radosavljević, Milica
AU  - Švob Štrac, Dubravka
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5407
AB  - Zaleplon is a positive allosteric modulator of the γ-aminobutyric acid (GABA)A receptor approved for the short-term treatment of insomnia. Previous publications on zaleplon have not addressed the proteins involved in its mechanism of action but have mostly referred to behavioral or pharmacological studies. Since both GABAergic and glutamatergic signaling have been shown to regulate wakefulness and sleep, we examined the effects of prolonged zaleplon treatment (0.625 mg/kg for 5 days) on these systems in the hippocampus of male Wistar rats. Western blot and immunohistochemical analyses showed that the upregulated components of GABAergic signaling (glutamate decarboxylase, vesicular GABA transporter, GABA, and α1 subunit of the GABAA receptor) were accompanied by increased protein levels in the glutamatergic system (vesicular glutamate transporter 1 and NR1, NR2A, and NR2B subunits of N-methyl-d-aspartate receptor). Our results, showing that zaleplon enhances GABA neurotransmission in the hippocampus, were not surprising. However, we found that treatment also increased glutamatergic signaling. This could be the result of the downregulation of adenosine A1 receptors, important modulators of the glutamatergic system. Further studies are needed to investigate the effects of the zaleplon-induced increase in hippocampal glutamatergic neurotransmission and the possible involvement of the adenosine system in zaleplon’s mechanism of action.
PB  - MDPI
T2  - Brain Sciences
T1  - Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus
VL  - 13
IS  - 12
DO  - 10.3390/brainsci13121707
ER  - 

@article{
author = "Martinović, Jelena and Samardžić, Janko and Zarić Kontić, Marina and Ivković, Sanja and Dacić, Sanja and Major, Tamara and Radosavljević, Milica and Švob Štrac, Dubravka",
year = "2023",
abstract = "Zaleplon is a positive allosteric modulator of the γ-aminobutyric acid (GABA)A receptor approved for the short-term treatment of insomnia. Previous publications on zaleplon have not addressed the proteins involved in its mechanism of action but have mostly referred to behavioral or pharmacological studies. Since both GABAergic and glutamatergic signaling have been shown to regulate wakefulness and sleep, we examined the effects of prolonged zaleplon treatment (0.625 mg/kg for 5 days) on these systems in the hippocampus of male Wistar rats. Western blot and immunohistochemical analyses showed that the upregulated components of GABAergic signaling (glutamate decarboxylase, vesicular GABA transporter, GABA, and α1 subunit of the GABAA receptor) were accompanied by increased protein levels in the glutamatergic system (vesicular glutamate transporter 1 and NR1, NR2A, and NR2B subunits of N-methyl-d-aspartate receptor). Our results, showing that zaleplon enhances GABA neurotransmission in the hippocampus, were not surprising. However, we found that treatment also increased glutamatergic signaling. This could be the result of the downregulation of adenosine A1 receptors, important modulators of the glutamatergic system. Further studies are needed to investigate the effects of the zaleplon-induced increase in hippocampal glutamatergic neurotransmission and the possible involvement of the adenosine system in zaleplon’s mechanism of action.",
publisher = "MDPI",
journal = "Brain Sciences",
title = "Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus",
volume = "13",
number = "12",
doi = "10.3390/brainsci13121707"
}

Martinović, J., Samardžić, J., Zarić Kontić, M., Ivković, S., Dacić, S., Major, T., Radosavljević, M.,& Švob Štrac, D.. (2023). Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus. in Brain Sciences
MDPI., 13(12).
https://doi.org/10.3390/brainsci13121707

Martinović J, Samardžić J, Zarić Kontić M, Ivković S, Dacić S, Major T, Radosavljević M, Švob Štrac D. Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus. in Brain Sciences. 2023;13(12).
doi:10.3390/brainsci13121707 .

Martinović, Jelena, Samardžić, Janko, Zarić Kontić, Marina, Ivković, Sanja, Dacić, Sanja, Major, Tamara, Radosavljević, Milica, Švob Štrac, Dubravka, "Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus" in Brain Sciences, 13, no. 12 (2023),
https://doi.org/10.3390/brainsci13121707 . .

TY  - JOUR
AU  - Totosković, Dragana
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2803
AB  - The purpose of the present study was to investigate neutrophil and monocyte cell population data as novel markers of low cobalamin/folate concentrations and influence of renal function on their usefulness. The study included 284 patients older than 60 years or with dyspepsia symptoms with mean corpuscular volume 80-100 fL and C-reactive protein  lt = 50 mg/l. Subjects were divided according to renal function and further classified based on cobalamin and folate levels. Neutrophil and monocyte volume (NeV, MoV), conductivity (NeC, MoC), light scatter (NeS, MoS) and standard deviations (NeV-SD, MoV-SD, NeCSD, MoC-SD, NeS-SD, MoS-SD), obtained by Coulter LH750 (R) Hematology Analyzer (Beckman Coulter, USA), were evaluated along with white blood cell count, hemoglobin, hematocrit, red cell distribution width and homocysteine relative to renal function and cobalamin/folate status. Neutrophil conductivity standard deviation (NeC-SD) had the largest magnitude of the difference between patients with low and normal vitamin levels, was the strongest predictor of low cobalamin/folate concentrations and had the largest area under the curve in detection of vitamin deficiency. Patients with different renal function status and the same cobalamin/folate status did not differ in NeC-SD. In this selected group of patients, NeC-SD was marker of low cobalamin and folate levels regardless of the renal function.
PB  - Univ South Bohemia, Ceska Budejovice
T2  - Journal of Applied Biomedicine
T1  - Evaluation of cell population data as potential markers of cobalamin and folate deficiency in populations at risk with regard to renal function
VL  - 15
IS  - 3
SP  - 204
EP  - 209
DO  - 10.1016/j.jab.2017.02.002
ER  - 

@article{
author = "Totosković, Dragana and Dopsaj, Violeta and Martinović, Jelena",
year = "2017",
abstract = "The purpose of the present study was to investigate neutrophil and monocyte cell population data as novel markers of low cobalamin/folate concentrations and influence of renal function on their usefulness. The study included 284 patients older than 60 years or with dyspepsia symptoms with mean corpuscular volume 80-100 fL and C-reactive protein  lt = 50 mg/l. Subjects were divided according to renal function and further classified based on cobalamin and folate levels. Neutrophil and monocyte volume (NeV, MoV), conductivity (NeC, MoC), light scatter (NeS, MoS) and standard deviations (NeV-SD, MoV-SD, NeCSD, MoC-SD, NeS-SD, MoS-SD), obtained by Coulter LH750 (R) Hematology Analyzer (Beckman Coulter, USA), were evaluated along with white blood cell count, hemoglobin, hematocrit, red cell distribution width and homocysteine relative to renal function and cobalamin/folate status. Neutrophil conductivity standard deviation (NeC-SD) had the largest magnitude of the difference between patients with low and normal vitamin levels, was the strongest predictor of low cobalamin/folate concentrations and had the largest area under the curve in detection of vitamin deficiency. Patients with different renal function status and the same cobalamin/folate status did not differ in NeC-SD. In this selected group of patients, NeC-SD was marker of low cobalamin and folate levels regardless of the renal function.",
publisher = "Univ South Bohemia, Ceska Budejovice",
journal = "Journal of Applied Biomedicine",
title = "Evaluation of cell population data as potential markers of cobalamin and folate deficiency in populations at risk with regard to renal function",
volume = "15",
number = "3",
pages = "204-209",
doi = "10.1016/j.jab.2017.02.002"
}

Totosković, D., Dopsaj, V.,& Martinović, J.. (2017). Evaluation of cell population data as potential markers of cobalamin and folate deficiency in populations at risk with regard to renal function. in Journal of Applied Biomedicine
Univ South Bohemia, Ceska Budejovice., 15(3), 204-209.
https://doi.org/10.1016/j.jab.2017.02.002

Totosković D, Dopsaj V, Martinović J. Evaluation of cell population data as potential markers of cobalamin and folate deficiency in populations at risk with regard to renal function. in Journal of Applied Biomedicine. 2017;15(3):204-209.
doi:10.1016/j.jab.2017.02.002 .

Totosković, Dragana, Dopsaj, Violeta, Martinović, Jelena, "Evaluation of cell population data as potential markers of cobalamin and folate deficiency in populations at risk with regard to renal function" in Journal of Applied Biomedicine, 15, no. 3 (2017):204-209,
https://doi.org/10.1016/j.jab.2017.02.002 . .

TY  - JOUR
AU  - Vukicević, Petar
AU  - Mikić, Aleksandar
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Milić, Nataša
AU  - Nikolić, Ljubinka
AU  - Martinović, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2621
AB  - This study aimed to evaluate the oxidative stress status and two markers of platelet activation and reactivity in off-pump versus on-pump coronary artery bypass surgery. Study groups of 65 patients with double coronary artery bypass grafting were divided into cardiopulmonary bypass (CPB) and off-pump coronary artery bypass groups. In serial blood samples, lipid hydroperoxides (LOOH), serum paraoxonase (PON1), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG) and red blood cell distribution width (RDW) to platelet (Plt) ratio (RPR) and mean platelet volume (MPV) to platelet (Plt) ratio (MPR) index were determined to compare the extent of oxidative stress and platelet activation. The MPR and RPR rose significantly in the post-operative period (P  lt  0.001) in both groups. The increase was higher in the CPB group, but this difference reached borderline significance at 48 h post-operatively. The AOPP/tSHG index increased 6 h after surgery, preceded by a significant fall of the PON1/LOOH ratio, more evident in the CPB group. Multiple linear regression analysis showed explicit connection between these markers and surgery-related clinical conditions. Receiver operating characteristic analysis enabled estimation of the clinical accuracy of oxidative plus platelet-related indices in prediction of surgery caused complications (area under the curve for the model consisted of oxidative stress parameters and platelet activation indices was above 0.9, P  lt  0.001). Results showed higher oxidative stress and undesirable platelet activation in the CPB group. Oxidative status markers and platelet activity indices showed good clinical accuracy to predict the development of possible surgical complications.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Biotechnology & Biotechnological Equipment
T1  - Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels
VL  - 30
IS  - 6
SP  - 1132
EP  - 1141
DO  - 10.1080/13102818.2016.1217168
ER  - 

@article{
author = "Vukicević, Petar and Mikić, Aleksandar and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Milić, Nataša and Nikolić, Ljubinka and Martinović, Jelena",
year = "2016",
abstract = "This study aimed to evaluate the oxidative stress status and two markers of platelet activation and reactivity in off-pump versus on-pump coronary artery bypass surgery. Study groups of 65 patients with double coronary artery bypass grafting were divided into cardiopulmonary bypass (CPB) and off-pump coronary artery bypass groups. In serial blood samples, lipid hydroperoxides (LOOH), serum paraoxonase (PON1), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG) and red blood cell distribution width (RDW) to platelet (Plt) ratio (RPR) and mean platelet volume (MPV) to platelet (Plt) ratio (MPR) index were determined to compare the extent of oxidative stress and platelet activation. The MPR and RPR rose significantly in the post-operative period (P  lt  0.001) in both groups. The increase was higher in the CPB group, but this difference reached borderline significance at 48 h post-operatively. The AOPP/tSHG index increased 6 h after surgery, preceded by a significant fall of the PON1/LOOH ratio, more evident in the CPB group. Multiple linear regression analysis showed explicit connection between these markers and surgery-related clinical conditions. Receiver operating characteristic analysis enabled estimation of the clinical accuracy of oxidative plus platelet-related indices in prediction of surgery caused complications (area under the curve for the model consisted of oxidative stress parameters and platelet activation indices was above 0.9, P  lt  0.001). Results showed higher oxidative stress and undesirable platelet activation in the CPB group. Oxidative status markers and platelet activity indices showed good clinical accuracy to predict the development of possible surgical complications.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Biotechnology & Biotechnological Equipment",
title = "Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels",
volume = "30",
number = "6",
pages = "1132-1141",
doi = "10.1080/13102818.2016.1217168"
}

Vukicević, P., Mikić, A., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Milić, N., Nikolić, L.,& Martinović, J.. (2016). Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels. in Biotechnology & Biotechnological Equipment
Taylor & Francis Ltd, Abingdon., 30(6), 1132-1141.
https://doi.org/10.1080/13102818.2016.1217168

Vukicević P, Mikić A, Kotur-Stevuljević J, Bogavac-Stanojević N, Milić N, Nikolić L, Martinović J. Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels. in Biotechnology & Biotechnological Equipment. 2016;30(6):1132-1141.
doi:10.1080/13102818.2016.1217168 .

Vukicević, Petar, Mikić, Aleksandar, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Milić, Nataša, Nikolić, Ljubinka, Martinović, Jelena, "Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels" in Biotechnology & Biotechnological Equipment, 30, no. 6 (2016):1132-1141,
https://doi.org/10.1080/13102818.2016.1217168 . .

TY  - JOUR
AU  - Stanisavljević, Nataša
AU  - Stojanović, Ljudmila
AU  - Marisavljević, D.
AU  - Đoković, A.
AU  - Dopsaj, Violeta
AU  - Kotur-Stevuljević, Jelena
AU  - Martinović, Jelena
AU  - Memon, Lidija
AU  - Radovanović, Slavica
AU  - Todić, B.
AU  - Lisulov, D.
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2710
AB  - The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p  lt  0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p  lt  0.05). FMD was lower in APS patients comparing to controls (p  lt  0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients.
PB  - Springer London Ltd, London
T2  - Clinical Rheumatology
T1  - Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients
VL  - 35
IS  - 10
SP  - 2485
EP  - 2493
DO  - 10.1007/s10067-016-3369-8
ER  - 

@article{
author = "Stanisavljević, Nataša and Stojanović, Ljudmila and Marisavljević, D. and Đoković, A. and Dopsaj, Violeta and Kotur-Stevuljević, Jelena and Martinović, Jelena and Memon, Lidija and Radovanović, Slavica and Todić, B. and Lisulov, D.",
year = "2016",
abstract = "The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p  lt  0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p  lt  0.05). FMD was lower in APS patients comparing to controls (p  lt  0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients.",
publisher = "Springer London Ltd, London",
journal = "Clinical Rheumatology",
title = "Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients",
volume = "35",
number = "10",
pages = "2485-2493",
doi = "10.1007/s10067-016-3369-8"
}

Stanisavljević, N., Stojanović, L., Marisavljević, D., Đoković, A., Dopsaj, V., Kotur-Stevuljević, J., Martinović, J., Memon, L., Radovanović, S., Todić, B.,& Lisulov, D.. (2016). Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. in Clinical Rheumatology
Springer London Ltd, London., 35(10), 2485-2493.
https://doi.org/10.1007/s10067-016-3369-8

Stanisavljević N, Stojanović L, Marisavljević D, Đoković A, Dopsaj V, Kotur-Stevuljević J, Martinović J, Memon L, Radovanović S, Todić B, Lisulov D. Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. in Clinical Rheumatology. 2016;35(10):2485-2493.
doi:10.1007/s10067-016-3369-8 .

Stanisavljević, Nataša, Stojanović, Ljudmila, Marisavljević, D., Đoković, A., Dopsaj, Violeta, Kotur-Stevuljević, Jelena, Martinović, Jelena, Memon, Lidija, Radovanović, Slavica, Todić, B., Lisulov, D., "Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients" in Clinical Rheumatology, 35, no. 10 (2016):2485-2493,
https://doi.org/10.1007/s10067-016-3369-8 . .

TY  - CONF
AU  - Totosković, Dragana
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2697
PB  - Wiley-Blackwell, Hoboken
C3  - International Journal of Laboratory Hematology
T1  - Methylmalonic acid and neutrophil morphometric index in cobalamin status assessment
VL  - 38
SP  - 107
EP  - 108
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2697
ER  - 

@conference{
author = "Totosković, Dragana and Dopsaj, Violeta and Martinović, Jelena",
year = "2016",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Laboratory Hematology",
title = "Methylmalonic acid and neutrophil morphometric index in cobalamin status assessment",
volume = "38",
pages = "107-108",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2697"
}

Totosković, D., Dopsaj, V.,& Martinović, J.. (2016). Methylmalonic acid and neutrophil morphometric index in cobalamin status assessment. in International Journal of Laboratory Hematology
Wiley-Blackwell, Hoboken., 38, 107-108.
https://hdl.handle.net/21.15107/rcub_farfar_2697

Totosković D, Dopsaj V, Martinović J. Methylmalonic acid and neutrophil morphometric index in cobalamin status assessment. in International Journal of Laboratory Hematology. 2016;38:107-108.
https://hdl.handle.net/21.15107/rcub_farfar_2697 .

Totosković, Dragana, Dopsaj, Violeta, Martinović, Jelena, "Methylmalonic acid and neutrophil morphometric index in cobalamin status assessment" in International Journal of Laboratory Hematology, 38 (2016):107-108,
https://hdl.handle.net/21.15107/rcub_farfar_2697 .

TY  - JOUR
AU  - Totosković, Dragana
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2589
AB  - IntroductionThis study aimed to investigate the utility of methylmalonic acid (MMA) and neutrophil Cell Population Data, available on the Beckman Coulter LH750 Analyser (Miami, FL, USA), in laboratory assessment of cobalamin status in patients at risk of cobalamin deficiency, without macrocytosis and inflammation. MethodsThe study group included 189 patients. Neutrophil Cell Population Data along with vitamin B12 and homocysteine were assessed in regard to MMA tertile groups. ResultsStatistically significant differences were between lower and upper MMA tertile in serum B12 (P ? 0.001), homocysteine (P = 0.001) and neutrophil morphometric index, NeS-DW (P = 0.029). Also, serum B12 concentrations were significantly different between lower and middle MMA tertile, P = 0.005. Receiver operating characteristic analysis of NeS-DW ability to detect MMA?367 nmol/L revealed a significant area under the curve AUC = 0.761 P ? 0.001 95% CI 0.693-0.830. Optimal cut-off value was NeS-DW?3.51% with sensitivity of 74.19% and specificity of 68.87%. ConclusionIn patients at risk of cobalamin deficiency and normal MCV, classification according to MMA revealed cobalamin status differences. Neutrophil morphometric index may be an indicator of early changes in neutrophil nucleus morphology caused by impaired cobalamin status.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Laboratory Hematology
T1  - Methylmalonic acid and neutrophil morphometric index in laboratory diagnosis of cobalamin deficiency without macrocytosis
VL  - 38
IS  - 3
SP  - 265
EP  - 272
DO  - 10.1111/ijlh.12479
ER  - 

@article{
author = "Totosković, Dragana and Dopsaj, Violeta and Martinović, Jelena",
year = "2016",
abstract = "IntroductionThis study aimed to investigate the utility of methylmalonic acid (MMA) and neutrophil Cell Population Data, available on the Beckman Coulter LH750 Analyser (Miami, FL, USA), in laboratory assessment of cobalamin status in patients at risk of cobalamin deficiency, without macrocytosis and inflammation. MethodsThe study group included 189 patients. Neutrophil Cell Population Data along with vitamin B12 and homocysteine were assessed in regard to MMA tertile groups. ResultsStatistically significant differences were between lower and upper MMA tertile in serum B12 (P ? 0.001), homocysteine (P = 0.001) and neutrophil morphometric index, NeS-DW (P = 0.029). Also, serum B12 concentrations were significantly different between lower and middle MMA tertile, P = 0.005. Receiver operating characteristic analysis of NeS-DW ability to detect MMA?367 nmol/L revealed a significant area under the curve AUC = 0.761 P ? 0.001 95% CI 0.693-0.830. Optimal cut-off value was NeS-DW?3.51% with sensitivity of 74.19% and specificity of 68.87%. ConclusionIn patients at risk of cobalamin deficiency and normal MCV, classification according to MMA revealed cobalamin status differences. Neutrophil morphometric index may be an indicator of early changes in neutrophil nucleus morphology caused by impaired cobalamin status.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Laboratory Hematology",
title = "Methylmalonic acid and neutrophil morphometric index in laboratory diagnosis of cobalamin deficiency without macrocytosis",
volume = "38",
number = "3",
pages = "265-272",
doi = "10.1111/ijlh.12479"
}

Totosković, D., Dopsaj, V.,& Martinović, J.. (2016). Methylmalonic acid and neutrophil morphometric index in laboratory diagnosis of cobalamin deficiency without macrocytosis. in International Journal of Laboratory Hematology
Wiley-Blackwell, Hoboken., 38(3), 265-272.
https://doi.org/10.1111/ijlh.12479

Totosković D, Dopsaj V, Martinović J. Methylmalonic acid and neutrophil morphometric index in laboratory diagnosis of cobalamin deficiency without macrocytosis. in International Journal of Laboratory Hematology. 2016;38(3):265-272.
doi:10.1111/ijlh.12479 .

Totosković, Dragana, Dopsaj, Violeta, Martinović, Jelena, "Methylmalonic acid and neutrophil morphometric index in laboratory diagnosis of cobalamin deficiency without macrocytosis" in International Journal of Laboratory Hematology, 38, no. 3 (2016):265-272,
https://doi.org/10.1111/ijlh.12479 . .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
AU  - Dopsaj, Milivoj
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2171
AB  - Introduction: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf((R))), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes. Methods: A total of 142 athletes were divided into three groups: with iron depletion, with iron-deficient erythropoiesis, and controls. The following parameters were measured: RBCs (red blood cells), Hb (hemoglobin), Hct (hematocrit), MCV (mean cellular volume), MCH (mean cell hemoglobin), MCHC (mean cell hemoglobin corpuscular), RDW (red cell distribution width), Maf((R)), Reticulocytes, Ferritin, sTfR (soluble transferrin receptor), Transferrin, Haptoglobin, IL- 6 (Interleukin-6), hs-CRP (high-sensitivity C-reactive protein). Results: The best Maf((R)) value to exclude iron depletion in athletes was 130.3, showing a sensitivity of 72.6% and a specificity of 57.3%. The AUC was 0.690 (CI 95% 0.607-0.765, P lt 0.001). ROC curve analysis for Maf((R)) in the diagnosis of iron-deficient erythropoiesis indicates sensitivity of 61.5%, and specificity of 93.0%, with AUC=0.826 (CI 95% 0.754-0.885, P lt 0.001) and on cutoff value 114. Conclusions: This study shows that Maf((R)), generated by the Coulter LH 700 Series hematology analyzers, performs very well in discriminating healthy athletes and those with different stages of iron deficiency. Also, in cost/benefit terms, monitoring of Maf((R)) is justified as a low cost, effective screening parameter for determining iron status in athletes.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Laboratory Hematology
T1  - Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?
VL  - 36
IS  - 1
SP  - 37
EP  - 44
DO  - 10.1111/ijlh.12115
ER  - 

@article{
author = "Dopsaj, Violeta and Martinović, Jelena and Dopsaj, Milivoj",
year = "2014",
abstract = "Introduction: The aim of this study was to establish the sensitivity and specificity of the microcytic anemia factor (Maf((R))), which is generated by the Coulter LH 750 analyzer in the evaluation of iron depletion and iron-deficient erythropoiesis in athletes. Methods: A total of 142 athletes were divided into three groups: with iron depletion, with iron-deficient erythropoiesis, and controls. The following parameters were measured: RBCs (red blood cells), Hb (hemoglobin), Hct (hematocrit), MCV (mean cellular volume), MCH (mean cell hemoglobin), MCHC (mean cell hemoglobin corpuscular), RDW (red cell distribution width), Maf((R)), Reticulocytes, Ferritin, sTfR (soluble transferrin receptor), Transferrin, Haptoglobin, IL- 6 (Interleukin-6), hs-CRP (high-sensitivity C-reactive protein). Results: The best Maf((R)) value to exclude iron depletion in athletes was 130.3, showing a sensitivity of 72.6% and a specificity of 57.3%. The AUC was 0.690 (CI 95% 0.607-0.765, P lt 0.001). ROC curve analysis for Maf((R)) in the diagnosis of iron-deficient erythropoiesis indicates sensitivity of 61.5%, and specificity of 93.0%, with AUC=0.826 (CI 95% 0.754-0.885, P lt 0.001) and on cutoff value 114. Conclusions: This study shows that Maf((R)), generated by the Coulter LH 700 Series hematology analyzers, performs very well in discriminating healthy athletes and those with different stages of iron deficiency. Also, in cost/benefit terms, monitoring of Maf((R)) is justified as a low cost, effective screening parameter for determining iron status in athletes.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Laboratory Hematology",
title = "Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?",
volume = "36",
number = "1",
pages = "37-44",
doi = "10.1111/ijlh.12115"
}

Dopsaj, V., Martinović, J.,& Dopsaj, M.. (2014). Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?. in International Journal of Laboratory Hematology
Wiley-Blackwell, Hoboken., 36(1), 37-44.
https://doi.org/10.1111/ijlh.12115

Dopsaj V, Martinović J, Dopsaj M. Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?. in International Journal of Laboratory Hematology. 2014;36(1):37-44.
doi:10.1111/ijlh.12115 .

Dopsaj, Violeta, Martinović, Jelena, Dopsaj, Milivoj, "Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful?" in International Journal of Laboratory Hematology, 36, no. 1 (2014):37-44,
https://doi.org/10.1111/ijlh.12115 . .

TY  - JOUR
AU  - Martinović, Jelena
AU  - Dopsaj, Violeta
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2123
AB  - Oxidative stress, which occurs as a result of physical exercise, has been intensively investigated in the last two decades. A large number of studies have been done on humans and in animal models, which resulted in clarification of the mechanism of free radical generation during exercise. Free radicals, unstable and reactive molecules that can be involved in cellular damage, are mainly generated by the mitochondria, xanthine oxidase, and neutrophils and other phagocytes. Increased production of free radicals during exercise is followed by the enhanced activity of the endogenous antioxidant defense system, which consists of enzymes and non-enzymatic substances. Very important results of previous studies have been related to adaptation mechanisms activated in response to increased oxidative stress during exercise. In addition to mitochondrial biogenesis and synthesis of new components of the respiratory chain to match higher energy demands, adaptation to regular physical exercise involves an increased expression of genes responsible for antioxidant enzyme synthesis. Also, great attention has been paid to the use of antioxidant supplements. The importance and effect of supplementation with dietary antioxidants depend on several factors such as intensity, frequency and mode of exercise as well as on the type and dose of the antioxidants used. Applying the results of previous research and monitoring the parameters of oxidative stress and antioxidative defense could help health professionals in understanding the medical condition of the athlete.
PB  - Sportska akademija, Beograd
T2  - Serbian Journal of Sports sciences
T1  - Oxidative stress in athletes: From the scientific basis to practical aspects
VL  - 8
IS  - 1
SP  - 11
EP  - 22
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2123
ER  - 

@article{
author = "Martinović, Jelena and Dopsaj, Violeta",
year = "2014",
abstract = "Oxidative stress, which occurs as a result of physical exercise, has been intensively investigated in the last two decades. A large number of studies have been done on humans and in animal models, which resulted in clarification of the mechanism of free radical generation during exercise. Free radicals, unstable and reactive molecules that can be involved in cellular damage, are mainly generated by the mitochondria, xanthine oxidase, and neutrophils and other phagocytes. Increased production of free radicals during exercise is followed by the enhanced activity of the endogenous antioxidant defense system, which consists of enzymes and non-enzymatic substances. Very important results of previous studies have been related to adaptation mechanisms activated in response to increased oxidative stress during exercise. In addition to mitochondrial biogenesis and synthesis of new components of the respiratory chain to match higher energy demands, adaptation to regular physical exercise involves an increased expression of genes responsible for antioxidant enzyme synthesis. Also, great attention has been paid to the use of antioxidant supplements. The importance and effect of supplementation with dietary antioxidants depend on several factors such as intensity, frequency and mode of exercise as well as on the type and dose of the antioxidants used. Applying the results of previous research and monitoring the parameters of oxidative stress and antioxidative defense could help health professionals in understanding the medical condition of the athlete.",
publisher = "Sportska akademija, Beograd",
journal = "Serbian Journal of Sports sciences",
title = "Oxidative stress in athletes: From the scientific basis to practical aspects",
volume = "8",
number = "1",
pages = "11-22",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2123"
}

Martinović, J.,& Dopsaj, V.. (2014). Oxidative stress in athletes: From the scientific basis to practical aspects. in Serbian Journal of Sports sciences
Sportska akademija, Beograd., 8(1), 11-22.
https://hdl.handle.net/21.15107/rcub_farfar_2123

Martinović J, Dopsaj V. Oxidative stress in athletes: From the scientific basis to practical aspects. in Serbian Journal of Sports sciences. 2014;8(1):11-22.
https://hdl.handle.net/21.15107/rcub_farfar_2123 .

Martinović, Jelena, Dopsaj, Violeta, "Oxidative stress in athletes: From the scientific basis to practical aspects" in Serbian Journal of Sports sciences, 8, no. 1 (2014):11-22,
https://hdl.handle.net/21.15107/rcub_farfar_2123 .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
AU  - Dopsaj, Milivoj
AU  - Kasum, Goran
AU  - Kotur-Stevuljević, Jelena
AU  - Koropanovski, Nenad
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1900
AB  - The aim of this study was to profile hematological, oxidative stress, and immunological parameters in male athletes who practiced combat sports and to determine whether the type of combat sport influenced the measured parameters. Eighteen karate professionals, 15 wrestlers, and 14 kickboxers participated in the study. Hematological, iron-related, oxidative stress, and immunological parameters were measured at the beginning of a precompetitive period. The general linear model showed significant differences between the karate professionals, wrestlers, and kickboxers with respect to their hematological and iron status parameters (Wilks' Lambda = 0.270, F = 2.186, p  lt  0.05) and oxidative stress status (Wilks' Lambda = 0.529, F = 1.940, p  lt  0.05). The immature reticulocyte fraction was significantly higher in wrestlers (0.30 +/- 0.03) compared with kickboxers (0.24 +/- 0.04; p  lt  0.05) and karate professionals (0.26 +/- 0.04; p  lt  0.05). Low hemoglobin density was significantly lower in wrestlers and kickboxers (p  lt  0.05) compared with karate professionals (karate: 3.51 +/- 1.19, wrestlers: 1.95 +/- 1.10, and kickboxers: 1.77 +/- 0.76). Significant differences were observed between the karate professionals and wrestlers with respect to their pro-oxidant-antioxidant balance (437 +/- 103 vs. 323 +/- 148, p  lt  0.05) and superoxide-dismutase activity (SOD) (73 +/- 37 vs. 103 +/- 30, p  lt  0.05). All the measured parameters (with the exception of SOD activity) fell within their physiological ranges, indicating that the study participants represented a young and healthy male population. Hematological parameters differed between kickboxers and karate professionals. The low pro-oxidant-antioxidant balance and high SOD activity in wrestlers could be associated with the long-term impact of wrestling as a type of strenuous exercise.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Strength and Conditioning Research
T1  - Hematological, oxidative stress, and immune status profiling in elite combat sport athletes
VL  - 27
IS  - 12
SP  - 3506
EP  - 3514
DO  - 10.1519/JSC.0b013e31828ddeea
ER  - 

@article{
author = "Dopsaj, Violeta and Martinović, Jelena and Dopsaj, Milivoj and Kasum, Goran and Kotur-Stevuljević, Jelena and Koropanovski, Nenad",
year = "2013",
abstract = "The aim of this study was to profile hematological, oxidative stress, and immunological parameters in male athletes who practiced combat sports and to determine whether the type of combat sport influenced the measured parameters. Eighteen karate professionals, 15 wrestlers, and 14 kickboxers participated in the study. Hematological, iron-related, oxidative stress, and immunological parameters were measured at the beginning of a precompetitive period. The general linear model showed significant differences between the karate professionals, wrestlers, and kickboxers with respect to their hematological and iron status parameters (Wilks' Lambda = 0.270, F = 2.186, p  lt  0.05) and oxidative stress status (Wilks' Lambda = 0.529, F = 1.940, p  lt  0.05). The immature reticulocyte fraction was significantly higher in wrestlers (0.30 +/- 0.03) compared with kickboxers (0.24 +/- 0.04; p  lt  0.05) and karate professionals (0.26 +/- 0.04; p  lt  0.05). Low hemoglobin density was significantly lower in wrestlers and kickboxers (p  lt  0.05) compared with karate professionals (karate: 3.51 +/- 1.19, wrestlers: 1.95 +/- 1.10, and kickboxers: 1.77 +/- 0.76). Significant differences were observed between the karate professionals and wrestlers with respect to their pro-oxidant-antioxidant balance (437 +/- 103 vs. 323 +/- 148, p  lt  0.05) and superoxide-dismutase activity (SOD) (73 +/- 37 vs. 103 +/- 30, p  lt  0.05). All the measured parameters (with the exception of SOD activity) fell within their physiological ranges, indicating that the study participants represented a young and healthy male population. Hematological parameters differed between kickboxers and karate professionals. The low pro-oxidant-antioxidant balance and high SOD activity in wrestlers could be associated with the long-term impact of wrestling as a type of strenuous exercise.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Strength and Conditioning Research",
title = "Hematological, oxidative stress, and immune status profiling in elite combat sport athletes",
volume = "27",
number = "12",
pages = "3506-3514",
doi = "10.1519/JSC.0b013e31828ddeea"
}

Dopsaj, V., Martinović, J., Dopsaj, M., Kasum, G., Kotur-Stevuljević, J.,& Koropanovski, N.. (2013). Hematological, oxidative stress, and immune status profiling in elite combat sport athletes. in Journal of Strength and Conditioning Research
Lippincott Williams & Wilkins, Philadelphia., 27(12), 3506-3514.
https://doi.org/10.1519/JSC.0b013e31828ddeea

Dopsaj V, Martinović J, Dopsaj M, Kasum G, Kotur-Stevuljević J, Koropanovski N. Hematological, oxidative stress, and immune status profiling in elite combat sport athletes. in Journal of Strength and Conditioning Research. 2013;27(12):3506-3514.
doi:10.1519/JSC.0b013e31828ddeea .

Dopsaj, Violeta, Martinović, Jelena, Dopsaj, Milivoj, Kasum, Goran, Kotur-Stevuljević, Jelena, Koropanovski, Nenad, "Hematological, oxidative stress, and immune status profiling in elite combat sport athletes" in Journal of Strength and Conditioning Research, 27, no. 12 (2013):3506-3514,
https://doi.org/10.1519/JSC.0b013e31828ddeea . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Vujović, Ana
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Martinović, Jelena
AU  - Ardalić, Daniela
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1635
AB  - Background: Pregnancy is a stressful condition linked with altered lipid profile, increased oxidative stress and increased inflammation processes. The purpose of the present study was to determine the associations between those alterations with increased weight gain during pregnancy. Methods: The atherogenic index of plasma (AIP) and oxidative stress status parameters were determinated in 50 healthy and 172 pregnant women with non-complicated pregnancy. Pregnant women were divided in four groups according to body mass index (BMI) values (BMI quartiles). Results: Oxidative stress parameters were significantly lower in the control group compared with all the pregnant women quartiles. Unexpectedly, differences in oxidative stress parameters between BMI quartiles groups were not significant. The antioxidant defence parameters remained quite similar in the different BMI quartiles. Weight gain and paraoxonase-1 (PON1) activities were independently associated with increased AIP while weight gain and triglyceride concentration were found to be significant predictors of PON1 activities. Conclusions: The results of our current study indicate the association of maternal weight gain during pregnancy and altered lipid profile, elevated oxidative stress and changed antioxidative capacity of PON1. Taken together all these facts indicate possible increased risk of cardiovascular disease (CVD) development in later life if the weight gain during pregnancy is excessive.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy
VL  - 50
IS  - 11
SP  - 2019
EP  - 2025
DO  - 10.1515/cclm-2012-0117
ER  - 

@article{
author = "Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Martinović, Jelena and Ardalić, Daniela and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2012",
abstract = "Background: Pregnancy is a stressful condition linked with altered lipid profile, increased oxidative stress and increased inflammation processes. The purpose of the present study was to determine the associations between those alterations with increased weight gain during pregnancy. Methods: The atherogenic index of plasma (AIP) and oxidative stress status parameters were determinated in 50 healthy and 172 pregnant women with non-complicated pregnancy. Pregnant women were divided in four groups according to body mass index (BMI) values (BMI quartiles). Results: Oxidative stress parameters were significantly lower in the control group compared with all the pregnant women quartiles. Unexpectedly, differences in oxidative stress parameters between BMI quartiles groups were not significant. The antioxidant defence parameters remained quite similar in the different BMI quartiles. Weight gain and paraoxonase-1 (PON1) activities were independently associated with increased AIP while weight gain and triglyceride concentration were found to be significant predictors of PON1 activities. Conclusions: The results of our current study indicate the association of maternal weight gain during pregnancy and altered lipid profile, elevated oxidative stress and changed antioxidative capacity of PON1. Taken together all these facts indicate possible increased risk of cardiovascular disease (CVD) development in later life if the weight gain during pregnancy is excessive.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy",
volume = "50",
number = "11",
pages = "2019-2025",
doi = "10.1515/cclm-2012-0117"
}

Stefanović, A., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Martinović, J., Ardalić, D., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2012). Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 50(11), 2019-2025.
https://doi.org/10.1515/cclm-2012-0117

Stefanović A, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Martinović J, Ardalić D, Mandić-Marković V, Miković Ž, Cerović N. Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy. in Clinical Chemistry and Laboratory Medicine. 2012;50(11):2019-2025.
doi:10.1515/cclm-2012-0117 .

Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Martinović, Jelena, Ardalić, Daniela, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Association of the atherogenic index of plasma and oxidative stress status with weight gain during non-complicated pregnancy" in Clinical Chemistry and Laboratory Medicine, 50, no. 11 (2012):2019-2025,
https://doi.org/10.1515/cclm-2012-0117 . .

TY  - CONF
AU  - Dopsaj, Violeta
AU  - Miković-Golubović, Gordana
AU  - Martinović, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1751
PB  - Wiley-Blackwell, Malden
C3  - International Journal of Laboratory Hematology
T1  - Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease
VL  - 34
SP  - 112
EP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1751
ER  - 

@conference{
author = "Dopsaj, Violeta and Miković-Golubović, Gordana and Martinović, Jelena and Kalimanovska-Oštrić, Dimitra",
year = "2012",
publisher = "Wiley-Blackwell, Malden",
journal = "International Journal of Laboratory Hematology",
title = "Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease",
volume = "34",
pages = "112-112",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1751"
}

Dopsaj, V., Miković-Golubović, G., Martinović, J.,& Kalimanovska-Oštrić, D.. (2012). Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology
Wiley-Blackwell, Malden., 34, 112-112.
https://hdl.handle.net/21.15107/rcub_farfar_1751

Dopsaj V, Miković-Golubović G, Martinović J, Kalimanovska-Oštrić D. Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology. 2012;34:112-112.
https://hdl.handle.net/21.15107/rcub_farfar_1751 .

Dopsaj, Violeta, Miković-Golubović, Gordana, Martinović, Jelena, Kalimanovska-Oštrić, Dimitra, "Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease" in International Journal of Laboratory Hematology, 34 (2012):112-112,
https://hdl.handle.net/21.15107/rcub_farfar_1751 .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Miković-Golubović, Gordana
AU  - Martinović, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1672
AB  - Introduction: The aim of our study was to evaluate derived red blood cell parameters in determining the presence of iron depletion and iron-deficient erythropoiesis, as states that precede iron deficiency anemia, in adults with congenital heart disease. Methods: Eighty-eight adults who were diagnosed with congenital heart disease were divided into two groups (cyanotic and acyanotic). In both groups, congenital heart disease patients were then divided into three subgroups: with iron depletion, with iron-deficient erythropoiesis, and a control group. The following parameters were measured: complete blood count, reticulocytes, ferritin, soluble transferrin receptor, haptoglobin, lactate dehydrogenase, and calculated parameters: low hemoglobin density (LHD), red cell size factor (RSF), and microcytic anemia factor (MAF). Results: Discriminant analysis indicated statistically significant differences in the first discriminant function: Function 1 body iron, LHD, MAF, sTfR, and RSF (P  lt  0.001) in patients with acyanotic congenital heart disease and significant differences in both discriminant functions in patients with cyanotic congenital heart disease: Function 1 body iron, soluble transferrin receptor, LHD, RSF, MAF, lactate dehydrogenase, and haptoglobin (P = 0.008) and Function 2 reticulocytes (#), immature reticulocyte fraction and reticulocytes (%) (P = 0.049). Conclusions: Beside parameters that describe iron metabolism dynamics (body iron and soluble transferrin receptor), LHD, indicator of hypochromia, have the highest potential to differentiate and classify iron deficiency in patients with congenital heart disease.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Laboratory Hematology
T1  - Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease
VL  - 34
IS  - 5
SP  - 461
EP  - 472
DO  - 10.1111/j.1751-553X.2012.01417.x
ER  - 

@article{
author = "Dopsaj, Violeta and Miković-Golubović, Gordana and Martinović, Jelena and Kalimanovska-Oštrić, Dimitra",
year = "2012",
abstract = "Introduction: The aim of our study was to evaluate derived red blood cell parameters in determining the presence of iron depletion and iron-deficient erythropoiesis, as states that precede iron deficiency anemia, in adults with congenital heart disease. Methods: Eighty-eight adults who were diagnosed with congenital heart disease were divided into two groups (cyanotic and acyanotic). In both groups, congenital heart disease patients were then divided into three subgroups: with iron depletion, with iron-deficient erythropoiesis, and a control group. The following parameters were measured: complete blood count, reticulocytes, ferritin, soluble transferrin receptor, haptoglobin, lactate dehydrogenase, and calculated parameters: low hemoglobin density (LHD), red cell size factor (RSF), and microcytic anemia factor (MAF). Results: Discriminant analysis indicated statistically significant differences in the first discriminant function: Function 1 body iron, LHD, MAF, sTfR, and RSF (P  lt  0.001) in patients with acyanotic congenital heart disease and significant differences in both discriminant functions in patients with cyanotic congenital heart disease: Function 1 body iron, soluble transferrin receptor, LHD, RSF, MAF, lactate dehydrogenase, and haptoglobin (P = 0.008) and Function 2 reticulocytes (#), immature reticulocyte fraction and reticulocytes (%) (P = 0.049). Conclusions: Beside parameters that describe iron metabolism dynamics (body iron and soluble transferrin receptor), LHD, indicator of hypochromia, have the highest potential to differentiate and classify iron deficiency in patients with congenital heart disease.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Laboratory Hematology",
title = "Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease",
volume = "34",
number = "5",
pages = "461-472",
doi = "10.1111/j.1751-553X.2012.01417.x"
}

Dopsaj, V., Miković-Golubović, G., Martinović, J.,& Kalimanovska-Oštrić, D.. (2012). Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology
Wiley-Blackwell, Hoboken., 34(5), 461-472.
https://doi.org/10.1111/j.1751-553X.2012.01417.x

Dopsaj V, Miković-Golubović G, Martinović J, Kalimanovska-Oštrić D. Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology. 2012;34(5):461-472.
doi:10.1111/j.1751-553X.2012.01417.x .

Dopsaj, Violeta, Miković-Golubović, Gordana, Martinović, Jelena, Kalimanovska-Oštrić, Dimitra, "Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease" in International Journal of Laboratory Hematology, 34, no. 5 (2012):461-472,
https://doi.org/10.1111/j.1751-553X.2012.01417.x . .

TY  - JOUR
AU  - Milić, Radoje
AU  - Martinović, Jelena
AU  - Dopsaj, Milivoj
AU  - Dopsaj, Violeta
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1543
AB  - We investigated the iron-related haematological parameters in both male and female athletes participating in different sporting disciplines necessitating different metabolic energy demands. A total of 873 athletes (514 males, mean age: 22.08 +/- A 4.95 years and 359 females, mean age: 21.38 +/- A 3.88 years) were divided according to gender and to the predominant energy system required for participation in sport (aerobic, anaerobic or mixed) and haematological and iron-related parameters were measured. For both male and female athletes, significant differences related to the predominant energy system were found at a general level: male (Wilks' lambda = 0.798, F = 3.047, p  lt  0.001) and female (Wilks' lambda = 0.762, F = 2.591, p  lt  0.001). According to the ferritin cutoff value of 35 mu g/L, whole body iron and sTfR significantly differed in all three groups of male and female athletes (p  lt  0.001). The percentage of hypochromic erythrocytes in male athletes was significantly higher only in those who required an anaerobic energy source (p  lt  0.001), whilst in the females hypochromic erythrocytes (p  lt  0.001) and haemoglobin (anaerobic, p = 0.042; mixed, p = 0.006) were significantly different only in anaerobic and mixed energy source athletes. According to the ferritin cutoff value of 22 mu g/L, in females, whole body iron, sTfR and hypochromic erythrocytes were significantly higher in all three groups of athletes than those below the aforementioned cutoff value (p  lt  0.001). We conclude that the predominant energy system required for participation in sport affects haematological parameters. sTfR and body iron proved to be reliable parameters for monitoring the dynamics of iron metabolism and could contribute to successful iron-deficiency prevention.
PB  - Springer, New York
T2  - European Journal of Applied Physiology
T1  - Haematological and iron-related parameters in male and female athletes according to different metabolic energy demands
VL  - 111
IS  - 3
SP  - 449
EP  - 458
DO  - 10.1007/s00421-010-1656-7
ER  - 

@article{
author = "Milić, Radoje and Martinović, Jelena and Dopsaj, Milivoj and Dopsaj, Violeta",
year = "2011",
abstract = "We investigated the iron-related haematological parameters in both male and female athletes participating in different sporting disciplines necessitating different metabolic energy demands. A total of 873 athletes (514 males, mean age: 22.08 +/- A 4.95 years and 359 females, mean age: 21.38 +/- A 3.88 years) were divided according to gender and to the predominant energy system required for participation in sport (aerobic, anaerobic or mixed) and haematological and iron-related parameters were measured. For both male and female athletes, significant differences related to the predominant energy system were found at a general level: male (Wilks' lambda = 0.798, F = 3.047, p  lt  0.001) and female (Wilks' lambda = 0.762, F = 2.591, p  lt  0.001). According to the ferritin cutoff value of 35 mu g/L, whole body iron and sTfR significantly differed in all three groups of male and female athletes (p  lt  0.001). The percentage of hypochromic erythrocytes in male athletes was significantly higher only in those who required an anaerobic energy source (p  lt  0.001), whilst in the females hypochromic erythrocytes (p  lt  0.001) and haemoglobin (anaerobic, p = 0.042; mixed, p = 0.006) were significantly different only in anaerobic and mixed energy source athletes. According to the ferritin cutoff value of 22 mu g/L, in females, whole body iron, sTfR and hypochromic erythrocytes were significantly higher in all three groups of athletes than those below the aforementioned cutoff value (p  lt  0.001). We conclude that the predominant energy system required for participation in sport affects haematological parameters. sTfR and body iron proved to be reliable parameters for monitoring the dynamics of iron metabolism and could contribute to successful iron-deficiency prevention.",
publisher = "Springer, New York",
journal = "European Journal of Applied Physiology",
title = "Haematological and iron-related parameters in male and female athletes according to different metabolic energy demands",
volume = "111",
number = "3",
pages = "449-458",
doi = "10.1007/s00421-010-1656-7"
}

Milić, R., Martinović, J., Dopsaj, M.,& Dopsaj, V.. (2011). Haematological and iron-related parameters in male and female athletes according to different metabolic energy demands. in European Journal of Applied Physiology
Springer, New York., 111(3), 449-458.
https://doi.org/10.1007/s00421-010-1656-7

Milić R, Martinović J, Dopsaj M, Dopsaj V. Haematological and iron-related parameters in male and female athletes according to different metabolic energy demands. in European Journal of Applied Physiology. 2011;111(3):449-458.
doi:10.1007/s00421-010-1656-7 .

Milić, Radoje, Martinović, Jelena, Dopsaj, Milivoj, Dopsaj, Violeta, "Haematological and iron-related parameters in male and female athletes according to different metabolic energy demands" in European Journal of Applied Physiology, 111, no. 3 (2011):449-458,
https://doi.org/10.1007/s00421-010-1656-7 . .

TY  - JOUR
AU  - Martinović, Jelena
AU  - Dopsaj, Violeta
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Milivoj
AU  - Vujović, Ana
AU  - Stefanović, Aleksandra
AU  - Nesić, Goran
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1525
AB  - Martinovic, J, Dopsaj, V, Kotur-Stevuljevic, J, Dopsaj, M, Vujovic, A, Stefanovic, A, and Nesic, G. Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period. J Strength Cond Res 25(5): 1360-1367, 2011-The objectives of this study were to determine (a) if reactive oxygen metabolites (ROMs) are a reliable parameter for monitoring oxidative stress in athletes alone or in association with other parameters of oxidative stress and depending on whether antioxidant supplements are taken or not; (b) the level of oxidative stress in athletes before the competition season; and
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Strength and Conditioning Research
T1  - Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period
VL  - 25
IS  - 5
SP  - 1360
EP  - 1367
DO  - 10.1519/JSC.0b013e3181d85a7f
ER  - 

@article{
author = "Martinović, Jelena and Dopsaj, Violeta and Kotur-Stevuljević, Jelena and Dopsaj, Milivoj and Vujović, Ana and Stefanović, Aleksandra and Nesić, Goran",
year = "2011",
abstract = "Martinovic, J, Dopsaj, V, Kotur-Stevuljevic, J, Dopsaj, M, Vujovic, A, Stefanovic, A, and Nesic, G. Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period. J Strength Cond Res 25(5): 1360-1367, 2011-The objectives of this study were to determine (a) if reactive oxygen metabolites (ROMs) are a reliable parameter for monitoring oxidative stress in athletes alone or in association with other parameters of oxidative stress and depending on whether antioxidant supplements are taken or not; (b) the level of oxidative stress in athletes before the competition season; and",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Strength and Conditioning Research",
title = "Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period",
volume = "25",
number = "5",
pages = "1360-1367",
doi = "10.1519/JSC.0b013e3181d85a7f"
}

Martinović, J., Dopsaj, V., Kotur-Stevuljević, J., Dopsaj, M., Vujović, A., Stefanović, A.,& Nesić, G.. (2011). Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period. in Journal of Strength and Conditioning Research
Lippincott Williams & Wilkins, Philadelphia., 25(5), 1360-1367.
https://doi.org/10.1519/JSC.0b013e3181d85a7f

Martinović J, Dopsaj V, Kotur-Stevuljević J, Dopsaj M, Vujović A, Stefanović A, Nesić G. Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period. in Journal of Strength and Conditioning Research. 2011;25(5):1360-1367.
doi:10.1519/JSC.0b013e3181d85a7f .

Martinović, Jelena, Dopsaj, Violeta, Kotur-Stevuljević, Jelena, Dopsaj, Milivoj, Vujović, Ana, Stefanović, Aleksandra, Nesić, Goran, "Oxidative stress biomarker monitoring in elite women volleyball athletes during a 6-week training period" in Journal of Strength and Conditioning Research, 25, no. 5 (2011):1360-1367,
https://doi.org/10.1519/JSC.0b013e3181d85a7f . .

TY  - JOUR
AU  - Martinović, Jelena
AU  - Dopsaj, Violeta
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Milivoj
AU  - Stefanović, Aleksandra
AU  - Kasum, Goran
AU  - Vujović, Ana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1409
AB  - The main purpose of this study was to demonstrate the impact of different training regimes and the type of metabolism that predominates as the source of energy on the oxidative stress / anti-oxidative defense status in elite-level trained athletes. One hundred twenty-four athletes were divided into three groups: 'aerobic' (karate, rowing, triathlon), 'anaerobic' (wrestling and swimming) and 'mixed' (volleyball, water polo, kick boxing). The following parameters were measured: oxidative stress status parameters: [(reactive oxygen metabolites (ROMs), superoxide anion (O2 -), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and lipid hydroperoxides (LOOH)] and anti-oxidative defense parameters [biological anti-oxidative potential (BAP), superoxide-dismutase (SOD), sulphydryl groups (-SH) and pro-oxidant-antioxidant balance (PAB)]. In general, significant differences were found in oxidative stress parameters between three experimental groups (Wilks' Lambda = 0.366, F value = 8.185, p  lt  0.001). Comparing the athletes from the anaerobic and mixed groups, we found that the anaerobic group had significantly lower ROMs (p = 0.019), AOPP (p  lt  0.001), O2 - (p = 0.003) and LOOH (p  lt  0.001). The aerobic group of athletes differed from the group with mixed training regime by lower AOPP, MDA, O2 - and LOOH values (p  lt  0.001). Discriminant analysis of the three experimental groups indicated protein oxidation marker (AOPP) and pro-oxidant-antioxidant balance as the most important discriminant variables. Oxidative stress status parameters adequately discriminated 74.2 % of the athletes with different energy expenditure during their training programs. The results obtained provide evidence that there are differences in the oxidative stress / anti-oxidant defense status between athletes that have different energy expenditure during exercise and identify athletes who participate in team sports as most susceptible to oxidative stress. .
PB  - Sportska akademija, Beograd
T2  - Serbian Journal of Sports sciences
T1  - Are oxidative stress and antioxidant defense status associated with energy expenditure in athletes of various sports?
VL  - 4
IS  - 1-4
SP  - 75
EP  - 81
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1409
ER  - 

@article{
author = "Martinović, Jelena and Dopsaj, Violeta and Kotur-Stevuljević, Jelena and Dopsaj, Milivoj and Stefanović, Aleksandra and Kasum, Goran and Vujović, Ana",
year = "2010",
abstract = "The main purpose of this study was to demonstrate the impact of different training regimes and the type of metabolism that predominates as the source of energy on the oxidative stress / anti-oxidative defense status in elite-level trained athletes. One hundred twenty-four athletes were divided into three groups: 'aerobic' (karate, rowing, triathlon), 'anaerobic' (wrestling and swimming) and 'mixed' (volleyball, water polo, kick boxing). The following parameters were measured: oxidative stress status parameters: [(reactive oxygen metabolites (ROMs), superoxide anion (O2 -), malondialdehyde (MDA), advanced oxidation protein products (AOPP) and lipid hydroperoxides (LOOH)] and anti-oxidative defense parameters [biological anti-oxidative potential (BAP), superoxide-dismutase (SOD), sulphydryl groups (-SH) and pro-oxidant-antioxidant balance (PAB)]. In general, significant differences were found in oxidative stress parameters between three experimental groups (Wilks' Lambda = 0.366, F value = 8.185, p  lt  0.001). Comparing the athletes from the anaerobic and mixed groups, we found that the anaerobic group had significantly lower ROMs (p = 0.019), AOPP (p  lt  0.001), O2 - (p = 0.003) and LOOH (p  lt  0.001). The aerobic group of athletes differed from the group with mixed training regime by lower AOPP, MDA, O2 - and LOOH values (p  lt  0.001). Discriminant analysis of the three experimental groups indicated protein oxidation marker (AOPP) and pro-oxidant-antioxidant balance as the most important discriminant variables. Oxidative stress status parameters adequately discriminated 74.2 % of the athletes with different energy expenditure during their training programs. The results obtained provide evidence that there are differences in the oxidative stress / anti-oxidant defense status between athletes that have different energy expenditure during exercise and identify athletes who participate in team sports as most susceptible to oxidative stress. .",
publisher = "Sportska akademija, Beograd",
journal = "Serbian Journal of Sports sciences",
title = "Are oxidative stress and antioxidant defense status associated with energy expenditure in athletes of various sports?",
volume = "4",
number = "1-4",
pages = "75-81",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1409"
}

Martinović, J., Dopsaj, V., Kotur-Stevuljević, J., Dopsaj, M., Stefanović, A., Kasum, G.,& Vujović, A.. (2010). Are oxidative stress and antioxidant defense status associated with energy expenditure in athletes of various sports?. in Serbian Journal of Sports sciences
Sportska akademija, Beograd., 4(1-4), 75-81.
https://hdl.handle.net/21.15107/rcub_farfar_1409

Martinović J, Dopsaj V, Kotur-Stevuljević J, Dopsaj M, Stefanović A, Kasum G, Vujović A. Are oxidative stress and antioxidant defense status associated with energy expenditure in athletes of various sports?. in Serbian Journal of Sports sciences. 2010;4(1-4):75-81.
https://hdl.handle.net/21.15107/rcub_farfar_1409 .

Martinović, Jelena, Dopsaj, Violeta, Kotur-Stevuljević, Jelena, Dopsaj, Milivoj, Stefanović, Aleksandra, Kasum, Goran, Vujović, Ana, "Are oxidative stress and antioxidant defense status associated with energy expenditure in athletes of various sports?" in Serbian Journal of Sports sciences, 4, no. 1-4 (2010):75-81,
https://hdl.handle.net/21.15107/rcub_farfar_1409 .

TY  - JOUR
AU  - Martinović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Dopsaj, Violeta
AU  - Dopsaj, Milivoj
AU  - Stefanović, Aleksandra
AU  - Kasum, Goran
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1368
AB  - Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis
VL  - 43
IS  - 15
SP  - 1225
EP  - 1229
DO  - 10.1016/j.clinbiochem.2010.07.024
ER  - 

@article{
author = "Martinović, Jelena and Kotur-Stevuljević, Jelena and Dopsaj, Violeta and Dopsaj, Milivoj and Stefanović, Aleksandra and Kasum, Goran",
year = "2010",
abstract = "Objective: The aim of this study was to evaluate how conditions that precede anaemia (iron store depletion and iron-deficient erythropoiesis) affect human serum paraoxonase PON1 activity. Design and methods: Based on haemoglobin, transferrin saturation and serum ferritin values 119 athletes were divided into three groups: with iron depletion, with deficient erythropoiesis and controls. The following parameters were measured: paraoxonase activity towards paraoxon (POase) and diazoxon (DZOase), lipid hydroperoxides (LOOH), the pro-oxidant-antioxidant balance (PAB), red blood cells (RBC) and lipid status. Results: Significant differences were found between athletes with different stages of iron deficiency and controls with respect to PON 1 activity and oxidative stress status parameters (Wilks' Lambda = 0.712, F = 5.241, p lt 0.001, eta(2) = 0.156). There was no significant difference between the PON1 192 Q and R polymorphism distribution in the two groups of athletes with different stages of iron deficiency and controls (chi(2) = 1.086; p = 0.896). PON1 activity was positively correlated with RBCs, haemoglobin, transferrin saturation (p lt 0.001) and ferritin (p = 0.037) and negatively correlated with LOOH (p = 0.044) in all three study groups. Conclusions: Deficient erythropoiesis in athletes contributes to impaired PON1 activity. In contrast, iron depletion, regardless of increased oxidative stress, does not affect PON1 activity.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis",
volume = "43",
number = "15",
pages = "1225-1229",
doi = "10.1016/j.clinbiochem.2010.07.024"
}

Martinović, J., Kotur-Stevuljević, J., Dopsaj, V., Dopsaj, M., Stefanović, A.,& Kasum, G.. (2010). Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 43(15), 1225-1229.
https://doi.org/10.1016/j.clinbiochem.2010.07.024

Martinović J, Kotur-Stevuljević J, Dopsaj V, Dopsaj M, Stefanović A, Kasum G. Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis. in Clinical Biochemistry. 2010;43(15):1225-1229.
doi:10.1016/j.clinbiochem.2010.07.024 .

Martinović, Jelena, Kotur-Stevuljević, Jelena, Dopsaj, Violeta, Dopsaj, Milivoj, Stefanović, Aleksandra, Kasum, Goran, "Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis" in Clinical Biochemistry, 43, no. 15 (2010):1225-1229,
https://doi.org/10.1016/j.clinbiochem.2010.07.024 . .

TY  - JOUR
AU  - Vujović, Ana
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Bujisić, Nada
AU  - Martinović, Jelena
AU  - Vujović, Milica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Pajić, Dragoljub
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1374
AB  - Background: Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis. In the present study we validated existing formulas and derived a more accurate formula to determine LDL-C in a Serbian population. Methods: Our study included 2053 patients with TG  lt = 4.52 mmol/L. In an initial group of 1010 patients, Friedewald's and Anandaraja's formulas were compared to a direct homogenous method for LDL-C determination. The obtained results allowed us to modify Friedewald's formula and apply it in a second group of patients. Results: The mean LDL-C concentrations were 3.9 +/- 1.09 mmol/L, 3.63 +/- 1.06 mmol/L and 3.72 +/- 1.04 mmol/L measured by a direct homogenous assay (D-LDL-C), calculated by Friedewald's formula (F-LDL-C) and calculated by Anandaraja's formula (A-LDL-C), respectively in the 1010 patients. The Student's paired t-test showed that D-LDL-C values were significantly higher than F-LDL-C and A-LDL-C values (p  lt  0.001). The Passing-Bablok regression analysis indicated good correlation between calculated and measured LDL-Cs (r > 0.89). Using lipoprotein values from the initial group we modified Friedewald's formula by replacing the term 2.2 with 3. The new modified formula for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to D-LDL-C. The absolute bias between these two methods was -0.06 +/- 0.37 mmol/L with a high correlation coefficient (r = 0.96). Conclusions: Our modified formula for LDL-C estimation appears to be more accurate than both Friedewald's and Anandaraja's formulas when applied to a Serbian population.
PB  - BMC, LONDON
T2  - Lipids in Health and Disease
T1  - Evaluation of different formulas for LDL-C calculation
VL  - 9
DO  - 10.1186/1476-511X-9-27
ER  - 

@article{
author = "Vujović, Ana and Kotur-Stevuljević, Jelena and Spasić, Slavica and Bujisić, Nada and Martinović, Jelena and Vujović, Milica and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Pajić, Dragoljub",
year = "2010",
abstract = "Background: Friedewald's formula for the estimation of LDL-C concentration is the most often used formula in clinical practice. A recent formula by Anandaraja and colleagues for LDL-C estimation still needs to be evaluated before it is extensively applied in diagnosis. In the present study we validated existing formulas and derived a more accurate formula to determine LDL-C in a Serbian population. Methods: Our study included 2053 patients with TG  lt = 4.52 mmol/L. In an initial group of 1010 patients, Friedewald's and Anandaraja's formulas were compared to a direct homogenous method for LDL-C determination. The obtained results allowed us to modify Friedewald's formula and apply it in a second group of patients. Results: The mean LDL-C concentrations were 3.9 +/- 1.09 mmol/L, 3.63 +/- 1.06 mmol/L and 3.72 +/- 1.04 mmol/L measured by a direct homogenous assay (D-LDL-C), calculated by Friedewald's formula (F-LDL-C) and calculated by Anandaraja's formula (A-LDL-C), respectively in the 1010 patients. The Student's paired t-test showed that D-LDL-C values were significantly higher than F-LDL-C and A-LDL-C values (p  lt  0.001). The Passing-Bablok regression analysis indicated good correlation between calculated and measured LDL-Cs (r > 0.89). Using lipoprotein values from the initial group we modified Friedewald's formula by replacing the term 2.2 with 3. The new modified formula for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to D-LDL-C. The absolute bias between these two methods was -0.06 +/- 0.37 mmol/L with a high correlation coefficient (r = 0.96). Conclusions: Our modified formula for LDL-C estimation appears to be more accurate than both Friedewald's and Anandaraja's formulas when applied to a Serbian population.",
publisher = "BMC, LONDON",
journal = "Lipids in Health and Disease",
title = "Evaluation of different formulas for LDL-C calculation",
volume = "9",
doi = "10.1186/1476-511X-9-27"
}

Vujović, A., Kotur-Stevuljević, J., Spasić, S., Bujisić, N., Martinović, J., Vujović, M., Spasojević-Kalimanovska, V., Zeljković, A.,& Pajić, D.. (2010). Evaluation of different formulas for LDL-C calculation. in Lipids in Health and Disease
BMC, LONDON., 9.
https://doi.org/10.1186/1476-511X-9-27

Vujović A, Kotur-Stevuljević J, Spasić S, Bujisić N, Martinović J, Vujović M, Spasojević-Kalimanovska V, Zeljković A, Pajić D. Evaluation of different formulas for LDL-C calculation. in Lipids in Health and Disease. 2010;9.
doi:10.1186/1476-511X-9-27 .

Vujović, Ana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Bujisić, Nada, Martinović, Jelena, Vujović, Milica, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Pajić, Dragoljub, "Evaluation of different formulas for LDL-C calculation" in Lipids in Health and Disease, 9 (2010),
https://doi.org/10.1186/1476-511X-9-27 . .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Bogavac-Stanojević, Nataša
AU  - Vasić, Dragan
AU  - Vukosavljević, Dragana
AU  - Martinović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1180
AB  - Many studies have investigated the clinical accuracy of the D-dimer test in combination with pretest probability score for deep venous thrombosis (DVT) exclusion. However, few have evaluated its potential when combined with additional markers such as fibrin monomer. The aim of this study was to test the incremental usefulness of fibrin monomer for DVT screening in a bi-marker approach. This was achieved by adding the fibrin monomer to logistic models that included different D-dimer tests. Plasma concentrations of D-dimer and fibrin monomer were measured in 96 outpatients suspected of having DVT and in 76 patients selected from the total patient group according to pretest probability score (termed the DVT-unlikely group). We constructed receiver operating characteristic curves for three different D-dimer assays. Predictive probabilities from different logistic regression models and pair-wise comparisons of the areas under the receiver operating characteristic curve (AUCs) were calculated without and with fibrin monomer included in the models. For all three D-dimer assays, the AUCs were higher in the DVT-unlikely group compared with AUCs in the total patient group [but the differences were without statistical significance (P>0.05)]. The calculated fibrin monomer AUCs (0.724 in the total patient group and 0.683 in the DVT-unlikely group) were lower than the D-dimer tests' AUCs. The AUCs obtained from logistic regression models that included the three D-dimer tests in the total patient group and the DVT-unlikely group were significantly increased when fibrin monomer was included in the model to such an extent that the AUCs for one of them indicated outstanding discriminative abilities. Simultaneous D-dimer and fibrin monomer determination provides a more valuable approximation for DVT exclusion compared with just D-dimer analysis. Bearing in mind that the fibrin monomer assay is now both more practical and more suited for routine clinical use, fibrin monomer determination could be a more commonly used parameter together with D-dimer and pretest probability score for DVT diagnosis in the future. Blood Coagul Fibrinolysis 20:546-551
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Blood Coagulation & Fibrinolysis
T1  - Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?
VL  - 20
IS  - 7
SP  - 546
EP  - 551
DO  - 10.1097/MBC.0b013e32832e0605
ER  - 

@article{
author = "Dopsaj, Violeta and Bogavac-Stanojević, Nataša and Vasić, Dragan and Vukosavljević, Dragana and Martinović, Jelena and Kotur-Stevuljević, Jelena and Spasić, Slavica",
year = "2009",
abstract = "Many studies have investigated the clinical accuracy of the D-dimer test in combination with pretest probability score for deep venous thrombosis (DVT) exclusion. However, few have evaluated its potential when combined with additional markers such as fibrin monomer. The aim of this study was to test the incremental usefulness of fibrin monomer for DVT screening in a bi-marker approach. This was achieved by adding the fibrin monomer to logistic models that included different D-dimer tests. Plasma concentrations of D-dimer and fibrin monomer were measured in 96 outpatients suspected of having DVT and in 76 patients selected from the total patient group according to pretest probability score (termed the DVT-unlikely group). We constructed receiver operating characteristic curves for three different D-dimer assays. Predictive probabilities from different logistic regression models and pair-wise comparisons of the areas under the receiver operating characteristic curve (AUCs) were calculated without and with fibrin monomer included in the models. For all three D-dimer assays, the AUCs were higher in the DVT-unlikely group compared with AUCs in the total patient group [but the differences were without statistical significance (P>0.05)]. The calculated fibrin monomer AUCs (0.724 in the total patient group and 0.683 in the DVT-unlikely group) were lower than the D-dimer tests' AUCs. The AUCs obtained from logistic regression models that included the three D-dimer tests in the total patient group and the DVT-unlikely group were significantly increased when fibrin monomer was included in the model to such an extent that the AUCs for one of them indicated outstanding discriminative abilities. Simultaneous D-dimer and fibrin monomer determination provides a more valuable approximation for DVT exclusion compared with just D-dimer analysis. Bearing in mind that the fibrin monomer assay is now both more practical and more suited for routine clinical use, fibrin monomer determination could be a more commonly used parameter together with D-dimer and pretest probability score for DVT diagnosis in the future. Blood Coagul Fibrinolysis 20:546-551",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Blood Coagulation & Fibrinolysis",
title = "Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?",
volume = "20",
number = "7",
pages = "546-551",
doi = "10.1097/MBC.0b013e32832e0605"
}

Dopsaj, V., Bogavac-Stanojević, N., Vasić, D., Vukosavljević, D., Martinović, J., Kotur-Stevuljević, J.,& Spasić, S.. (2009). Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?. in Blood Coagulation & Fibrinolysis
Lippincott Williams & Wilkins, Philadelphia., 20(7), 546-551.
https://doi.org/10.1097/MBC.0b013e32832e0605

Dopsaj V, Bogavac-Stanojević N, Vasić D, Vukosavljević D, Martinović J, Kotur-Stevuljević J, Spasić S. Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?. in Blood Coagulation & Fibrinolysis. 2009;20(7):546-551.
doi:10.1097/MBC.0b013e32832e0605 .

Dopsaj, Violeta, Bogavac-Stanojević, Nataša, Vasić, Dragan, Vukosavljević, Dragana, Martinović, Jelena, Kotur-Stevuljević, Jelena, Spasić, Slavica, "Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?" in Blood Coagulation & Fibrinolysis, 20, no. 7 (2009):546-551,
https://doi.org/10.1097/MBC.0b013e32832e0605 . .