TY  - JOUR
AU  - Antić-Stanković, Jelena
AU  - Stanković, Sanja
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2855
AB  - The complement system plays an important role in host defense. It is composed of series of plasma proteins which, when activated in a sequential reaction, unleashes a powerful destructive activity towards invading pathogens. Three major pathways exist in the activation of complement: the classical pathway, which is initiated by antibody-antigen binding, the alternative pathway, which is activated by a susceptible foreign surface, and the lectin pathways, which can be triggered by manann-binding lectins. The complement system consists of serum and cell surface proteins that interact with one another and with other molecules of the immune system in a highly regulated manner. Complement proteins are plasma proteins that are normally inactive and they are activated only under particular conditions to generate products that mediate various effector functions of the complement.
AB  - Sistem komplementa ima značajnu ulogu u odbrani domaćina od patogena. Sastoji se od niza proteina plazme koji se aktiviraju u kaskadnom procesu, dovodeći do oštećenja patogena. Opisana su tri puta aktivacije sistema komplementa: klasičan (aktivira se vezivanjem C1q komponente komplementa za kompleks antigen-antitelo), alternativni (aktivira se direktnim vezivanjem C3b komponente komplementa za površinske molekule mikroorganizama) i lektinski (indukovan je vezivanjem manoza vezućeg proteina za manozne rezidue na površini mikroorganizama). Najvažnija uloga sistema komplementa u urođenom i specifičnom imunitetu je stimulisanje fagocitoze, liza mikroorganizama i pospešivanje inflamacije. Komplement ima ključnu ulogu i u uklanjanju imunskih kompleksa.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš
T2  - Acta medica Medianae
T1  - The complement system: Pathways of activations and functions
T1  - Sistem komplementa - putevi aktivacije i funkcija
VL  - 56
IS  - 1
SP  - 50
EP  - 55
DO  - 10.5633/amm.2017.0108
ER  - 

@article{
author = "Antić-Stanković, Jelena and Stanković, Sanja",
year = "2017",
abstract = "The complement system plays an important role in host defense. It is composed of series of plasma proteins which, when activated in a sequential reaction, unleashes a powerful destructive activity towards invading pathogens. Three major pathways exist in the activation of complement: the classical pathway, which is initiated by antibody-antigen binding, the alternative pathway, which is activated by a susceptible foreign surface, and the lectin pathways, which can be triggered by manann-binding lectins. The complement system consists of serum and cell surface proteins that interact with one another and with other molecules of the immune system in a highly regulated manner. Complement proteins are plasma proteins that are normally inactive and they are activated only under particular conditions to generate products that mediate various effector functions of the complement., Sistem komplementa ima značajnu ulogu u odbrani domaćina od patogena. Sastoji se od niza proteina plazme koji se aktiviraju u kaskadnom procesu, dovodeći do oštećenja patogena. Opisana su tri puta aktivacije sistema komplementa: klasičan (aktivira se vezivanjem C1q komponente komplementa za kompleks antigen-antitelo), alternativni (aktivira se direktnim vezivanjem C3b komponente komplementa za površinske molekule mikroorganizama) i lektinski (indukovan je vezivanjem manoza vezućeg proteina za manozne rezidue na površini mikroorganizama). Najvažnija uloga sistema komplementa u urođenom i specifičnom imunitetu je stimulisanje fagocitoze, liza mikroorganizama i pospešivanje inflamacije. Komplement ima ključnu ulogu i u uklanjanju imunskih kompleksa.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš",
journal = "Acta medica Medianae",
title = "The complement system: Pathways of activations and functions, Sistem komplementa - putevi aktivacije i funkcija",
volume = "56",
number = "1",
pages = "50-55",
doi = "10.5633/amm.2017.0108"
}

Antić-Stanković, J.,& Stanković, S.. (2017). The complement system: Pathways of activations and functions. in Acta medica Medianae
Univerzitet u Nišu - Medicinski fakultet, Niš., 56(1), 50-55.
https://doi.org/10.5633/amm.2017.0108

Antić-Stanković J, Stanković S. The complement system: Pathways of activations and functions. in Acta medica Medianae. 2017;56(1):50-55.
doi:10.5633/amm.2017.0108 .

Antić-Stanković, Jelena, Stanković, Sanja, "The complement system: Pathways of activations and functions" in Acta medica Medianae, 56, no. 1 (2017):50-55,
https://doi.org/10.5633/amm.2017.0108 . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Buha, Aleksandra
AU  - Stanković, Sanja
AU  - Milovanović, Vesna
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Vucnić, Slavica
AU  - Matović, Vesna
AU  - Antonijević, Biljana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2948
AB  - The objective of this study was to assess toxicity of Cd and BDE-209 mixture on haematological parameters in subacutely exposed rats and to determine the presence and type of interactions between these two chemicals using multiple factorial regression analysis. Furthermore, for the assessment of interaction type, an isobologram based methodology was applied and compared with multiple factorial regression analysis. Chemicals were given by oral gavage to the male Wistar rats weighing 200-240g for 28 days. Animals were divided in 16 groups (8/group): control vehiculum group, three groups of rats were treated with 2.5, 7.5 or 15 mg Cd/kg/day. These doses were chosen on the bases of literature data and reflect relatively high Cd environmental exposure, three groups of rats were treated with 1000, 2000 or 4000 mg BDE-209/kg/bw/day, doses proved to induce toxic effects in rats. Furthermore, nine groups of animals were treated with different mixtures of Cd and BDE-209 containing doses of Cd and BDE-209 stated above. Blood samples were taken at the end of experiment and red blood cells, white blood cells and platelets counts were determined. For interaction assessment multiple factorial regression analysis and fitted isobologram approach were used. In this study, we focused on multiple factorial regression analysis as a method for interaction assessment. We also investigated the interactions between Cd and BDE-209 by the derived model for the description of the obtained fitted isobologram curves. Current study indicated that co-exposure to Cd and BDE-209 can result in significant decrease in RBC count, increase in WBC count and decrease in PLT count, when compared with controls. Multiple factorial regression analysis used for the assessment of interactions type between Cd and BDE-209 indicated synergism for the effect on RBC count and no interactions i.e. additivity for the effects on WBC and PLT counts. On the other hand, isobologram based approach showed slight antagonism for the effects on RBC and WBC while no interactions were proved for the joint effect on PLT count. These results confirm that the assessment of interactions between chemicals in the mixture greatly depends on the concept or method used for this evaluation.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology and Industrial Health
T1  - Interactions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysis
VL  - 376
SP  - 120
EP  - 125
DO  - 10.1016/j.tox.2016.05.011
ER  - 

@article{
author = "Ćurčić, Marijana and Buha, Aleksandra and Stanković, Sanja and Milovanović, Vesna and Bulat, Zorica and Đukić-Ćosić, Danijela and Antonijević, Evica and Vucnić, Slavica and Matović, Vesna and Antonijević, Biljana",
year = "2017",
abstract = "The objective of this study was to assess toxicity of Cd and BDE-209 mixture on haematological parameters in subacutely exposed rats and to determine the presence and type of interactions between these two chemicals using multiple factorial regression analysis. Furthermore, for the assessment of interaction type, an isobologram based methodology was applied and compared with multiple factorial regression analysis. Chemicals were given by oral gavage to the male Wistar rats weighing 200-240g for 28 days. Animals were divided in 16 groups (8/group): control vehiculum group, three groups of rats were treated with 2.5, 7.5 or 15 mg Cd/kg/day. These doses were chosen on the bases of literature data and reflect relatively high Cd environmental exposure, three groups of rats were treated with 1000, 2000 or 4000 mg BDE-209/kg/bw/day, doses proved to induce toxic effects in rats. Furthermore, nine groups of animals were treated with different mixtures of Cd and BDE-209 containing doses of Cd and BDE-209 stated above. Blood samples were taken at the end of experiment and red blood cells, white blood cells and platelets counts were determined. For interaction assessment multiple factorial regression analysis and fitted isobologram approach were used. In this study, we focused on multiple factorial regression analysis as a method for interaction assessment. We also investigated the interactions between Cd and BDE-209 by the derived model for the description of the obtained fitted isobologram curves. Current study indicated that co-exposure to Cd and BDE-209 can result in significant decrease in RBC count, increase in WBC count and decrease in PLT count, when compared with controls. Multiple factorial regression analysis used for the assessment of interactions type between Cd and BDE-209 indicated synergism for the effect on RBC count and no interactions i.e. additivity for the effects on WBC and PLT counts. On the other hand, isobologram based approach showed slight antagonism for the effects on RBC and WBC while no interactions were proved for the joint effect on PLT count. These results confirm that the assessment of interactions between chemicals in the mixture greatly depends on the concept or method used for this evaluation.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology and Industrial Health",
title = "Interactions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysis",
volume = "376",
pages = "120-125",
doi = "10.1016/j.tox.2016.05.011"
}

Ćurčić, M., Buha, A., Stanković, S., Milovanović, V., Bulat, Z., Đukić-Ćosić, D., Antonijević, E., Vucnić, S., Matović, V.,& Antonijević, B.. (2017). Interactions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysis. in Toxicology and Industrial Health
Elsevier Ireland Ltd, Clare., 376, 120-125.
https://doi.org/10.1016/j.tox.2016.05.011

Ćurčić M, Buha A, Stanković S, Milovanović V, Bulat Z, Đukić-Ćosić D, Antonijević E, Vucnić S, Matović V, Antonijević B. Interactions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysis. in Toxicology and Industrial Health. 2017;376:120-125.
doi:10.1016/j.tox.2016.05.011 .

Ćurčić, Marijana, Buha, Aleksandra, Stanković, Sanja, Milovanović, Vesna, Bulat, Zorica, Đukić-Ćosić, Danijela, Antonijević, Evica, Vucnić, Slavica, Matović, Vesna, Antonijević, Biljana, "Interactions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysis" in Toxicology and Industrial Health, 376 (2017):120-125,
https://doi.org/10.1016/j.tox.2016.05.011 . .

TY  - JOUR
AU  - Alempijević, Tamara
AU  - Zec, Simon
AU  - Nikolić, Vladimir
AU  - Veljković, Aleksandar
AU  - Milivojević, Vladimir
AU  - Dopsaj, Violeta
AU  - Stanković, Sanja
AU  - Milosavljević, Tomica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2670
AB  - Background & Aims: Acute-on-chronic liver failure (ACLF) is characterized by a rapid progression to multiple organ failure and is associated with a very high mortality rate of 50-90%. Novel therapies are being investigated such as Erythropoietin (EPO). The aim of this prospective cohort study was to analyse the value of EPO in predicting prognosis and determine which patients may benefit most from EPO therapy. Methods: According to the EASL-CLIF criteria, 104 consecutive patients were diagnosed with ACLF, and separated into two groups based on the type of insult: bleeding (Group A=31) or non-bleeding (Group B=73). In addition to a complete biochemical work-up and calculation of relevant prognostic scores, levels of EPO were measured on admission and correlated to the type of insult and final outcome. Results: Fifteen patients from Group A (mean age 60.32 +/- 9.29 years) had a lethal outcome and higher values of EPO on admission (319.26 +/- 326.58 mIU/ml) (p lt 0.005), compared to the 37 patients from Group B (mean age 59.9 +/- 10.19 years) with EPO levels at admission of 29.88 +/- 34.6 mIU/mL. In Group B, a cut-off EPO value of 30.65 mIU/mL had a sensitivity of 87.5% and a specificity 57.4% in predicting lethal outcome with an AUROC of 0.823. In Group A, a cut-off value of 229.95 mlU/mL had a sensitivity and specificity of 53.3% and 92.7%, respectively. The AUROC for this cut-off was 0.847. Conclusions: Erythropoietin is superior to the standard prognostic scores in predicting 28-day mortality. Lower levels of EPO were detected in patients without bleeding as an insult indicating a possible therapeutic benefit in these patients.
PB  - Medical Univ Press, Cluj-Napoca
T2  - Journal of Gastrointestinal and Liver Diseases
T1  - Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure
VL  - 25
IS  - 4
SP  - 473
EP  - 479
DO  - 10.15403/jgld.2014.1121.254.jev
ER  - 

@article{
author = "Alempijević, Tamara and Zec, Simon and Nikolić, Vladimir and Veljković, Aleksandar and Milivojević, Vladimir and Dopsaj, Violeta and Stanković, Sanja and Milosavljević, Tomica",
year = "2016",
abstract = "Background & Aims: Acute-on-chronic liver failure (ACLF) is characterized by a rapid progression to multiple organ failure and is associated with a very high mortality rate of 50-90%. Novel therapies are being investigated such as Erythropoietin (EPO). The aim of this prospective cohort study was to analyse the value of EPO in predicting prognosis and determine which patients may benefit most from EPO therapy. Methods: According to the EASL-CLIF criteria, 104 consecutive patients were diagnosed with ACLF, and separated into two groups based on the type of insult: bleeding (Group A=31) or non-bleeding (Group B=73). In addition to a complete biochemical work-up and calculation of relevant prognostic scores, levels of EPO were measured on admission and correlated to the type of insult and final outcome. Results: Fifteen patients from Group A (mean age 60.32 +/- 9.29 years) had a lethal outcome and higher values of EPO on admission (319.26 +/- 326.58 mIU/ml) (p lt 0.005), compared to the 37 patients from Group B (mean age 59.9 +/- 10.19 years) with EPO levels at admission of 29.88 +/- 34.6 mIU/mL. In Group B, a cut-off EPO value of 30.65 mIU/mL had a sensitivity of 87.5% and a specificity 57.4% in predicting lethal outcome with an AUROC of 0.823. In Group A, a cut-off value of 229.95 mlU/mL had a sensitivity and specificity of 53.3% and 92.7%, respectively. The AUROC for this cut-off was 0.847. Conclusions: Erythropoietin is superior to the standard prognostic scores in predicting 28-day mortality. Lower levels of EPO were detected in patients without bleeding as an insult indicating a possible therapeutic benefit in these patients.",
publisher = "Medical Univ Press, Cluj-Napoca",
journal = "Journal of Gastrointestinal and Liver Diseases",
title = "Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure",
volume = "25",
number = "4",
pages = "473-479",
doi = "10.15403/jgld.2014.1121.254.jev"
}

Alempijević, T., Zec, S., Nikolić, V., Veljković, A., Milivojević, V., Dopsaj, V., Stanković, S.,& Milosavljević, T.. (2016). Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure. in Journal of Gastrointestinal and Liver Diseases
Medical Univ Press, Cluj-Napoca., 25(4), 473-479.
https://doi.org/10.15403/jgld.2014.1121.254.jev

Alempijević T, Zec S, Nikolić V, Veljković A, Milivojević V, Dopsaj V, Stanković S, Milosavljević T. Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure. in Journal of Gastrointestinal and Liver Diseases. 2016;25(4):473-479.
doi:10.15403/jgld.2014.1121.254.jev .

Alempijević, Tamara, Zec, Simon, Nikolić, Vladimir, Veljković, Aleksandar, Milivojević, Vladimir, Dopsaj, Violeta, Stanković, Sanja, Milosavljević, Tomica, "Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure" in Journal of Gastrointestinal and Liver Diseases, 25, no. 4 (2016):473-479,
https://doi.org/10.15403/jgld.2014.1121.254.jev . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Tanasković, Slađana
AU  - Stanković, Sanja
AU  - Janković, Saša
AU  - Antunović, Marko
AU  - Đorđević, Snežana
AU  - Kilibarda, Vesna
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2474
AB  - Background/Aim. Based on numerous studies in animals, the most prominent toxic effects of decabrominated di-phenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats. Methods. Effects were examined on male Wistar rats, weighing 200-240 g, exposed to doses of 1,000, 2,000 or 4,000 mg BDE-209/kg body weight (bw)/day by gavage during 28 days. Animals were treated according to the decision of the Ethics Committee of the Military Medical Academy, No 9667-1/2011. Evaluation of the hepatotoxic effect was based on: relative liver weight water and food intake, biochemical parameters of liver function [aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama glutamyl transferase (γ-GT)], and oxidative stress parameters in liver homogenates [malondialdehiyde (MDA), superoxide dismutase (SOD), -SH] and morphological and pathohistological changes in the liver. For the assessment of internal dose - response relationship, lower confidence limit of Benchmark dose (BMDL) of 5% or 10% i.e. BMDL5 or BMDL10, were calculated using PROAST software. Results. After the application of 1,000, 2,000 or 4,000 mg BDE-209/kg bw/day, the concentrations of BDE-209 measured in liver were 0.269, 0.569 and 0.859 mg/kg of liver wet weight, (ww) respectively. Internal doses correlated with external (r = 0.972; p  lt  0.05) according to equation: internal dose (mg BDE-209/kg of liver ww) = 0.0002 ' external dose (mg/kg bw/day) + 0.0622. Hepato-toxicity was demonstrated based on significant increase in AST and γ-GT activities and the degree of histopathological changes. The lowest BMDL5 of 0.07228 mg BDE-209/kg of liver ww, correlating to external dose of 39 mg/kg/day, indicated the increase of AST activity as the most sensitive biomarker of BDE-209 hepatotoxicity in subacutely ex-posed rats. Conclusion. The results of the present work add up to the issue of BDE-209 toxicity profile with a focus on relationship between internal dose and hepatotoxicity. Critical internal dose for the effect on AST of 0.07 mg/kg of liver ww, corresponding to external dose of 39 mg/kg/day, is the lowest dose ever observed among the studies on BDE-209 hepatotoxicity. For the persistent sub-stances with low absorption rate such as BDE-209, critical effect based on internal dose in majority of cases is considered as more precisely defined than the effect established based on external dose, particularly.
AB  - Uvod/Cilj. Prema podacima iz brojnih studija na životinjama, dekabromovani difeniletar (BDE-209) najznačajnije toksične efekte ispoljava na jetri, homeostazi hormona štitaste žlezde, reproduktivnom i nervnom sistemu. BDE-209 ispoljava toksične efekte delom preko receptora za aromatične ugljovodonike (Ah) i posledične indukcije mikrozomalnih enzima jetre. Cilj rada bio je procena hepatotoksičnog efekta u odnosu na dozu BDE-209 u ciljnom tkivu kod subakutno oralno eksponovanih Wistar pacova. Metode. Efekti su ispitivani na mužjacima Wistar pacova, mase 200-240 g, koji su putem oralne sonde primali doze od 1 000, 2 000 ili 4 000 mg BDE-209/kg telesne mase (tm) dan, tokom 28 dana. Životinje su tretirane u skladu sa odlukom Etičkog komiteta Vojnomedicinske akademije u Beogradu br. 9667-1/2011. Procena hepatotoksičnih efekata bazirana je na merenju relativne mase jetre, unosa vode i hrane, biohemijskih parametara funkcije jetre [aspartat aminotransferaza (AST), alanin amino-transferaza (ALT), alkalna fosfataza (ALP), gama glutamil transferaza (γ-GT)], parametara oksidativnog stresa u homogenatima jetre [malondialdehid (MDA), superoksid dizmutaza (SOD), -SH)] i morfoloških i histoloških promena na jetri. Za procenu odnosa interna doza - odgovor izračunavana je donja granica pouzdanosti granične Benchmark doze (BMDL) od 5% (BMDL5) ili 10% (BMDL10) primenom PROAST softvera. Rezultati. Koncentracije BDE-209 iznosile su 0,269, 0,569 i 0,859 mg/kg jetre nakon aplikacije 1 000, 2 000, odnosno 4 000 mg BDE-209/kg tm/dan. Interna doza u našoj studiji korelisala je sa eksternom dozom prema jednačini: interna doza (mg BDE-209/kg jetre) = 0,0002 ' eksterna doza (mg/kg tm/dan) + 0,0622 (r = 0,972; p  lt  0,05). Hepatotoksičnost je potvrđena na osnovu nalaza o povećanju aktivnosti enzima AST i γ-GT, kao i stepena patohistološkog oštećenja jetre. Najniža BMDL5 u eksperimentu od 0,07228 mg BDE-209/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan izračunata je za aktivnost AST i ukazuje na to da je aktivnost AST ujedno i najosetljiviji biomarker hepatotoksičnosti BDE-209 kod subakutno eksponovanih pacova. Zaključak. Rezultati prezentovane studije daju doprinos pitanju toksikološkog profila BDE-209 sa fokusom na odnos između interne doze i hepatotoksičnih efekata. Kritična interna doza za efekat na AST od 0,07 mg/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan, jeste ujedno i najniža kritična doza do sada definisana za hepatotoksične efekte BDE-209. Kritičan efekat koji se bazira na dozi u ciljnom tkivu u većini slučajeva može se smatrati preciznije definisanim od kritičnog efekta definisanog na bazi oralno primenjene doze, naročito za nedegradabilne supstance sa niskim stepenom apsorpcije, kao što je BDE-209.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats
T1  - Odnos hepatotoksičnosti i doze dekabromovanog difeniletra u ciljnom tkivu kod subakutno izloženih Wistar pacova
VL  - 72
IS  - 5
SP  - 405
EP  - 413
DO  - 10.2298/VSP1505405C
ER  - 

@article{
author = "Ćurčić, Marijana and Tanasković, Slađana and Stanković, Sanja and Janković, Saša and Antunović, Marko and Đorđević, Snežana and Kilibarda, Vesna and Vučinić, Slavica and Antonijević, Biljana",
year = "2015",
abstract = "Background/Aim. Based on numerous studies in animals, the most prominent toxic effects of decabrominated di-phenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats. Methods. Effects were examined on male Wistar rats, weighing 200-240 g, exposed to doses of 1,000, 2,000 or 4,000 mg BDE-209/kg body weight (bw)/day by gavage during 28 days. Animals were treated according to the decision of the Ethics Committee of the Military Medical Academy, No 9667-1/2011. Evaluation of the hepatotoxic effect was based on: relative liver weight water and food intake, biochemical parameters of liver function [aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gama glutamyl transferase (γ-GT)], and oxidative stress parameters in liver homogenates [malondialdehiyde (MDA), superoxide dismutase (SOD), -SH] and morphological and pathohistological changes in the liver. For the assessment of internal dose - response relationship, lower confidence limit of Benchmark dose (BMDL) of 5% or 10% i.e. BMDL5 or BMDL10, were calculated using PROAST software. Results. After the application of 1,000, 2,000 or 4,000 mg BDE-209/kg bw/day, the concentrations of BDE-209 measured in liver were 0.269, 0.569 and 0.859 mg/kg of liver wet weight, (ww) respectively. Internal doses correlated with external (r = 0.972; p  lt  0.05) according to equation: internal dose (mg BDE-209/kg of liver ww) = 0.0002 ' external dose (mg/kg bw/day) + 0.0622. Hepato-toxicity was demonstrated based on significant increase in AST and γ-GT activities and the degree of histopathological changes. The lowest BMDL5 of 0.07228 mg BDE-209/kg of liver ww, correlating to external dose of 39 mg/kg/day, indicated the increase of AST activity as the most sensitive biomarker of BDE-209 hepatotoxicity in subacutely ex-posed rats. Conclusion. The results of the present work add up to the issue of BDE-209 toxicity profile with a focus on relationship between internal dose and hepatotoxicity. Critical internal dose for the effect on AST of 0.07 mg/kg of liver ww, corresponding to external dose of 39 mg/kg/day, is the lowest dose ever observed among the studies on BDE-209 hepatotoxicity. For the persistent sub-stances with low absorption rate such as BDE-209, critical effect based on internal dose in majority of cases is considered as more precisely defined than the effect established based on external dose, particularly., Uvod/Cilj. Prema podacima iz brojnih studija na životinjama, dekabromovani difeniletar (BDE-209) najznačajnije toksične efekte ispoljava na jetri, homeostazi hormona štitaste žlezde, reproduktivnom i nervnom sistemu. BDE-209 ispoljava toksične efekte delom preko receptora za aromatične ugljovodonike (Ah) i posledične indukcije mikrozomalnih enzima jetre. Cilj rada bio je procena hepatotoksičnog efekta u odnosu na dozu BDE-209 u ciljnom tkivu kod subakutno oralno eksponovanih Wistar pacova. Metode. Efekti su ispitivani na mužjacima Wistar pacova, mase 200-240 g, koji su putem oralne sonde primali doze od 1 000, 2 000 ili 4 000 mg BDE-209/kg telesne mase (tm) dan, tokom 28 dana. Životinje su tretirane u skladu sa odlukom Etičkog komiteta Vojnomedicinske akademije u Beogradu br. 9667-1/2011. Procena hepatotoksičnih efekata bazirana je na merenju relativne mase jetre, unosa vode i hrane, biohemijskih parametara funkcije jetre [aspartat aminotransferaza (AST), alanin amino-transferaza (ALT), alkalna fosfataza (ALP), gama glutamil transferaza (γ-GT)], parametara oksidativnog stresa u homogenatima jetre [malondialdehid (MDA), superoksid dizmutaza (SOD), -SH)] i morfoloških i histoloških promena na jetri. Za procenu odnosa interna doza - odgovor izračunavana je donja granica pouzdanosti granične Benchmark doze (BMDL) od 5% (BMDL5) ili 10% (BMDL10) primenom PROAST softvera. Rezultati. Koncentracije BDE-209 iznosile su 0,269, 0,569 i 0,859 mg/kg jetre nakon aplikacije 1 000, 2 000, odnosno 4 000 mg BDE-209/kg tm/dan. Interna doza u našoj studiji korelisala je sa eksternom dozom prema jednačini: interna doza (mg BDE-209/kg jetre) = 0,0002 ' eksterna doza (mg/kg tm/dan) + 0,0622 (r = 0,972; p  lt  0,05). Hepatotoksičnost je potvrđena na osnovu nalaza o povećanju aktivnosti enzima AST i γ-GT, kao i stepena patohistološkog oštećenja jetre. Najniža BMDL5 u eksperimentu od 0,07228 mg BDE-209/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan izračunata je za aktivnost AST i ukazuje na to da je aktivnost AST ujedno i najosetljiviji biomarker hepatotoksičnosti BDE-209 kod subakutno eksponovanih pacova. Zaključak. Rezultati prezentovane studije daju doprinos pitanju toksikološkog profila BDE-209 sa fokusom na odnos između interne doze i hepatotoksičnih efekata. Kritična interna doza za efekat na AST od 0,07 mg/kg jetre, koja koreliše sa eksternom dozom od 39 mg/kg tm/dan, jeste ujedno i najniža kritična doza do sada definisana za hepatotoksične efekte BDE-209. Kritičan efekat koji se bazira na dozi u ciljnom tkivu u većini slučajeva može se smatrati preciznije definisanim od kritičnog efekta definisanog na bazi oralno primenjene doze, naročito za nedegradabilne supstance sa niskim stepenom apsorpcije, kao što je BDE-209.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats, Odnos hepatotoksičnosti i doze dekabromovanog difeniletra u ciljnom tkivu kod subakutno izloženih Wistar pacova",
volume = "72",
number = "5",
pages = "405-413",
doi = "10.2298/VSP1505405C"
}

Ćurčić, M., Tanasković, S., Stanković, S., Janković, S., Antunović, M., Đorđević, S., Kilibarda, V., Vučinić, S.,& Antonijević, B.. (2015). Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(5), 405-413.
https://doi.org/10.2298/VSP1505405C

Ćurčić M, Tanasković S, Stanković S, Janković S, Antunović M, Đorđević S, Kilibarda V, Vučinić S, Antonijević B. Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats. in Vojnosanitetski pregled. 2015;72(5):405-413.
doi:10.2298/VSP1505405C .

Ćurčić, Marijana, Tanasković, Slađana, Stanković, Sanja, Janković, Saša, Antunović, Marko, Đorđević, Snežana, Kilibarda, Vesna, Vučinić, Slavica, Antonijević, Biljana, "Relationship of hepatotoxicity and the target tissue dose of decabrominated diphenyl ether in subacutely exposed Wistar rats" in Vojnosanitetski pregled, 72, no. 5 (2015):405-413,
https://doi.org/10.2298/VSP1505405C . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Stanković, Sanja
AU  - Vučinić, Slavica
AU  - Jaćević, Vesna
AU  - Brkić, Dragica
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Evica
AU  - Antonijević, Biljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2219
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - The effects of Cd and BDE-209 co-exposure on hematological parameters in rats
VL  - 229
IS  - Supplement
SP  - S209
EP  - S209
DO  - 10.1016/j.toxlet.2014.06.704
ER  - 

@conference{
author = "Ćurčić, Marijana and Stanković, Sanja and Vučinić, Slavica and Jaćević, Vesna and Brkić, Dragica and Đukić-Ćosić, Danijela and Antonijević, Evica and Antonijević, Biljana",
year = "2014",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "The effects of Cd and BDE-209 co-exposure on hematological parameters in rats",
volume = "229",
number = "Supplement",
pages = "S209-S209",
doi = "10.1016/j.toxlet.2014.06.704"
}

Ćurčić, M., Stanković, S., Vučinić, S., Jaćević, V., Brkić, D., Đukić-Ćosić, D., Antonijević, E.,& Antonijević, B.. (2014). The effects of Cd and BDE-209 co-exposure on hematological parameters in rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 229(Supplement), S209-S209.
https://doi.org/10.1016/j.toxlet.2014.06.704

Ćurčić M, Stanković S, Vučinić S, Jaćević V, Brkić D, Đukić-Ćosić D, Antonijević E, Antonijević B. The effects of Cd and BDE-209 co-exposure on hematological parameters in rats. in Toxicology Letters. 2014;229(Supplement):S209-S209.
doi:10.1016/j.toxlet.2014.06.704 .

Ćurčić, Marijana, Stanković, Sanja, Vučinić, Slavica, Jaćević, Vesna, Brkić, Dragica, Đukić-Ćosić, Danijela, Antonijević, Evica, Antonijević, Biljana, "The effects of Cd and BDE-209 co-exposure on hematological parameters in rats" in Toxicology Letters, 229, no. Supplement (2014):S209-S209,
https://doi.org/10.1016/j.toxlet.2014.06.704 . .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Ašanin, Milika
AU  - Trifunović, Danijela
AU  - Majkić-Singh, Nada
AU  - Ignjatović, Svetlana
AU  - Mrdović, Igor
AU  - Matić, Dragan
AU  - Savić, Lidija
AU  - Marinković, Jelena
AU  - Ostojić, Miodrag
AU  - Vasiljević, Zorana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1752
AB  - Objectives: To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI). Design and methods: A total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24,48 and 168 hours (h) after pPCI. Results: MPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at 4 h and 2411 after pPCI. In-hospital mortality was 6%. MPO at 24 h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24 h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13-9.86, P = 0.029). Conclusions: In patients with the first anterior STEMI treated by pPCI. MPO at 24 h after procedure was an independent predictor of the in-hospital mortality.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention
VL  - 45
IS  - 7-8
SP  - 547
EP  - 551
DO  - 10.1016/j.clinbiochem.2012.02.015
ER  - 

@article{
author = "Stanković, Sanja and Ašanin, Milika and Trifunović, Danijela and Majkić-Singh, Nada and Ignjatović, Svetlana and Mrdović, Igor and Matić, Dragan and Savić, Lidija and Marinković, Jelena and Ostojić, Miodrag and Vasiljević, Zorana",
year = "2012",
abstract = "Objectives: To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI). Design and methods: A total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24,48 and 168 hours (h) after pPCI. Results: MPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at 4 h and 2411 after pPCI. In-hospital mortality was 6%. MPO at 24 h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24 h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13-9.86, P = 0.029). Conclusions: In patients with the first anterior STEMI treated by pPCI. MPO at 24 h after procedure was an independent predictor of the in-hospital mortality.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention",
volume = "45",
number = "7-8",
pages = "547-551",
doi = "10.1016/j.clinbiochem.2012.02.015"
}

Stanković, S., Ašanin, M., Trifunović, D., Majkić-Singh, N., Ignjatović, S., Mrdović, I., Matić, D., Savić, L., Marinković, J., Ostojić, M.,& Vasiljević, Z.. (2012). Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 45(7-8), 547-551.
https://doi.org/10.1016/j.clinbiochem.2012.02.015

Stanković S, Ašanin M, Trifunović D, Majkić-Singh N, Ignjatović S, Mrdović I, Matić D, Savić L, Marinković J, Ostojić M, Vasiljević Z. Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. in Clinical Biochemistry. 2012;45(7-8):547-551.
doi:10.1016/j.clinbiochem.2012.02.015 .

Stanković, Sanja, Ašanin, Milika, Trifunović, Danijela, Majkić-Singh, Nada, Ignjatović, Svetlana, Mrdović, Igor, Matić, Dragan, Savić, Lidija, Marinković, Jelena, Ostojić, Miodrag, Vasiljević, Zorana, "Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention" in Clinical Biochemistry, 45, no. 7-8 (2012):547-551,
https://doi.org/10.1016/j.clinbiochem.2012.02.015 . .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Ašanin, Milika
AU  - Majkić-Singh, Nada
AU  - Ignjatović, Svetlana
AU  - Mihailović, Mirjana
AU  - Nikolajević, Ivica
AU  - Mrdović, Igor
AU  - Matić, Dragan
AU  - Savić, Lidija
AU  - Marinković, Jelena
AU  - Ostojić, Miodrag
AU  - Vasiljević, Zorana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1701
AB  - Background: The predictive value of myeloperoxidase (MPO) in ST-segment elevation myocardial infarction (STEM I) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of the present study was to investigate MPO as a predictor of in-hospital mortality in STEMI patients treated by primary PCI. Methods: Study population consisted of 189 STEMI patients having undergone primary PCI. Plasma MPO level was measured 24 hours after symptom onset using chemiluminescent microparticle immunoassay (Abbott Diagnostics, Germany). The Receiver Operating Characteristic analysis was performed to identify the most useful MPO cut-off level for the prediction of in-hospital mortality. The patients were divided into two groups according to the cut-off MPO level: high MPO group (>= 840 pmol/L, n = 65) and low M PO group ( lt 840 pmol/L, n = 124). Results: The high M PO group had significantly more frequent anterior wall infarctions (p lt 0.001) and Killip class >1 on admission (p=0.013) as well as lower left ventricular ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP) (p=0.029) than the low MPO group. The incidence of in-hospital mortality was 5.8% and was significantly higher in the high M PO group (13.8%) than in the low MPO group (1.6%) (p=0.001). Multiple logistic regression analysis identified the plasma MPO level as an independent predictor of in-hospital mortality (OR 3.88, 95%CI 1.13 - 13.34, p=0.031). Conclusions: Plasma M PO level independently predicts in-hospital mortality in STEMI patients treated by primary PCI. (Clin. Lab. 2012;58:125-131)
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention
VL  - 58
IS  - 1-2
SP  - 125
EP  - 131
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1701
ER  - 

@article{
author = "Stanković, Sanja and Ašanin, Milika and Majkić-Singh, Nada and Ignjatović, Svetlana and Mihailović, Mirjana and Nikolajević, Ivica and Mrdović, Igor and Matić, Dragan and Savić, Lidija and Marinković, Jelena and Ostojić, Miodrag and Vasiljević, Zorana",
year = "2012",
abstract = "Background: The predictive value of myeloperoxidase (MPO) in ST-segment elevation myocardial infarction (STEM I) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of the present study was to investigate MPO as a predictor of in-hospital mortality in STEMI patients treated by primary PCI. Methods: Study population consisted of 189 STEMI patients having undergone primary PCI. Plasma MPO level was measured 24 hours after symptom onset using chemiluminescent microparticle immunoassay (Abbott Diagnostics, Germany). The Receiver Operating Characteristic analysis was performed to identify the most useful MPO cut-off level for the prediction of in-hospital mortality. The patients were divided into two groups according to the cut-off MPO level: high MPO group (>= 840 pmol/L, n = 65) and low M PO group ( lt 840 pmol/L, n = 124). Results: The high M PO group had significantly more frequent anterior wall infarctions (p lt 0.001) and Killip class >1 on admission (p=0.013) as well as lower left ventricular ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP) (p=0.029) than the low MPO group. The incidence of in-hospital mortality was 5.8% and was significantly higher in the high M PO group (13.8%) than in the low MPO group (1.6%) (p=0.001). Multiple logistic regression analysis identified the plasma MPO level as an independent predictor of in-hospital mortality (OR 3.88, 95%CI 1.13 - 13.34, p=0.031). Conclusions: Plasma M PO level independently predicts in-hospital mortality in STEMI patients treated by primary PCI. (Clin. Lab. 2012;58:125-131)",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention",
volume = "58",
number = "1-2",
pages = "125-131",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1701"
}

Stanković, S., Ašanin, M., Majkić-Singh, N., Ignjatović, S., Mihailović, M., Nikolajević, I., Mrdović, I., Matić, D., Savić, L., Marinković, J., Ostojić, M.,& Vasiljević, Z.. (2012). The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 58(1-2), 125-131.
https://hdl.handle.net/21.15107/rcub_farfar_1701

Stanković S, Ašanin M, Majkić-Singh N, Ignjatović S, Mihailović M, Nikolajević I, Mrdović I, Matić D, Savić L, Marinković J, Ostojić M, Vasiljević Z. The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention. in Clinical Laboratory. 2012;58(1-2):125-131.
https://hdl.handle.net/21.15107/rcub_farfar_1701 .

Stanković, Sanja, Ašanin, Milika, Majkić-Singh, Nada, Ignjatović, Svetlana, Mihailović, Mirjana, Nikolajević, Ivica, Mrdović, Igor, Matić, Dragan, Savić, Lidija, Marinković, Jelena, Ostojić, Miodrag, Vasiljević, Zorana, "The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention" in Clinical Laboratory, 58, no. 1-2 (2012):125-131,
https://hdl.handle.net/21.15107/rcub_farfar_1701 .

TY  - JOUR
AU  - Stanković, Sanja
AU  - Ašanin, Milika
AU  - Trifunović, Danijela
AU  - Majkić-Singh, Nada
AU  - Miljković, Aleksandar
AU  - Ignjatović, Svetlana
AU  - Mrdović, Igor
AU  - Matić, Dragan
AU  - Savić, Lidija
AU  - Ostojić, Miodrag
AU  - Vasiljević, Zorana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1687
AB  - Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been suggested as an inflammatory marker of cardiovascular risk. The predictive value of Lp-PLA(2) in ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of this study was to determine whether plasma Lp-PLA(2) is a predictor of a major adverse cardiac event (MACE) in patients with the first anterior STEMI treated by primary PCI. Methods: This study consisted of 100 consecutive patients with first anterior STEMI who underwent primary PCI within 6 hours of the symptom onset. Plasma Lp-PLA(2) level was measured on admission using a turbidimetric immunoassay (diaDexus, Inc., USA). The Receiver Operating Characteristic analysis was performed to identify the most useful Lp-PLA(2) cut-off level for the prediction of MACE. The patients were divided into two groups according to the cut-off Lp-PLA(2) level: high Lp-PLA(2) group (>= 463 ng/mL, n = 33) and low Lp-PLA(2) group ( lt  463 ng/mL, n = 67). MACE was defined as cardiac death, non-fatal reinfarction, and target vessel revascularization. Results: Patients in the high Lp-PLA(2) group had significantly higher total-, LDL-cholesterol, apolipoprotein B levels, and significantly lower estimated glomerular filtration rates compared with the low Lp-PLA(2) group. The incidence of 30-day mortality was 18.2% (6/33) in high Lp-PLA(2) group, while in the low Lp-PLA(2) group no patient died (p  lt  0.001). The 30-day MACE occurred in 24.2% of the high Lp-PLA(2) group and 3% of the low Lp-PLA(2) group (p = 0.001). Multiple logistic regression analysis identified the plasma Lp-PLA(2) level as an independent predictor of MACE (OR 1.011, 95%CI 1.001 - 1.013, p = 0.037). Conclusions: In patients with first anterior STEMI treated by primary PCI, the plasma Lp-PLA(2) level is an independent predictor of 30-day MACE. (Clin. Lab. 2012;58:1135-1144. DOI: 10.7754/Clin.Lab.2012.111102)
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Utility of Lipoprotein-Associated Phospholipase A(2) for Prediction of 30-day Major Adverse Coronary Event in Patients with the First Anterior ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention
VL  - 58
IS  - 11-12
SP  - 1135
EP  - 1144
DO  - 10.7754/Clin.Lab.2012.111102
ER  - 

@article{
author = "Stanković, Sanja and Ašanin, Milika and Trifunović, Danijela and Majkić-Singh, Nada and Miljković, Aleksandar and Ignjatović, Svetlana and Mrdović, Igor and Matić, Dragan and Savić, Lidija and Ostojić, Miodrag and Vasiljević, Zorana",
year = "2012",
abstract = "Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been suggested as an inflammatory marker of cardiovascular risk. The predictive value of Lp-PLA(2) in ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of this study was to determine whether plasma Lp-PLA(2) is a predictor of a major adverse cardiac event (MACE) in patients with the first anterior STEMI treated by primary PCI. Methods: This study consisted of 100 consecutive patients with first anterior STEMI who underwent primary PCI within 6 hours of the symptom onset. Plasma Lp-PLA(2) level was measured on admission using a turbidimetric immunoassay (diaDexus, Inc., USA). The Receiver Operating Characteristic analysis was performed to identify the most useful Lp-PLA(2) cut-off level for the prediction of MACE. The patients were divided into two groups according to the cut-off Lp-PLA(2) level: high Lp-PLA(2) group (>= 463 ng/mL, n = 33) and low Lp-PLA(2) group ( lt  463 ng/mL, n = 67). MACE was defined as cardiac death, non-fatal reinfarction, and target vessel revascularization. Results: Patients in the high Lp-PLA(2) group had significantly higher total-, LDL-cholesterol, apolipoprotein B levels, and significantly lower estimated glomerular filtration rates compared with the low Lp-PLA(2) group. The incidence of 30-day mortality was 18.2% (6/33) in high Lp-PLA(2) group, while in the low Lp-PLA(2) group no patient died (p  lt  0.001). The 30-day MACE occurred in 24.2% of the high Lp-PLA(2) group and 3% of the low Lp-PLA(2) group (p = 0.001). Multiple logistic regression analysis identified the plasma Lp-PLA(2) level as an independent predictor of MACE (OR 1.011, 95%CI 1.001 - 1.013, p = 0.037). Conclusions: In patients with first anterior STEMI treated by primary PCI, the plasma Lp-PLA(2) level is an independent predictor of 30-day MACE. (Clin. Lab. 2012;58:1135-1144. DOI: 10.7754/Clin.Lab.2012.111102)",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Utility of Lipoprotein-Associated Phospholipase A(2) for Prediction of 30-day Major Adverse Coronary Event in Patients with the First Anterior ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention",
volume = "58",
number = "11-12",
pages = "1135-1144",
doi = "10.7754/Clin.Lab.2012.111102"
}

Stanković, S., Ašanin, M., Trifunović, D., Majkić-Singh, N., Miljković, A., Ignjatović, S., Mrdović, I., Matić, D., Savić, L., Ostojić, M.,& Vasiljević, Z.. (2012). Utility of Lipoprotein-Associated Phospholipase A(2) for Prediction of 30-day Major Adverse Coronary Event in Patients with the First Anterior ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 58(11-12), 1135-1144.
https://doi.org/10.7754/Clin.Lab.2012.111102

Stanković S, Ašanin M, Trifunović D, Majkić-Singh N, Miljković A, Ignjatović S, Mrdović I, Matić D, Savić L, Ostojić M, Vasiljević Z. Utility of Lipoprotein-Associated Phospholipase A(2) for Prediction of 30-day Major Adverse Coronary Event in Patients with the First Anterior ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention. in Clinical Laboratory. 2012;58(11-12):1135-1144.
doi:10.7754/Clin.Lab.2012.111102 .

Stanković, Sanja, Ašanin, Milika, Trifunović, Danijela, Majkić-Singh, Nada, Miljković, Aleksandar, Ignjatović, Svetlana, Mrdović, Igor, Matić, Dragan, Savić, Lidija, Ostojić, Miodrag, Vasiljević, Zorana, "Utility of Lipoprotein-Associated Phospholipase A(2) for Prediction of 30-day Major Adverse Coronary Event in Patients with the First Anterior ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention" in Clinical Laboratory, 58, no. 11-12 (2012):1135-1144,
https://doi.org/10.7754/Clin.Lab.2012.111102 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Stanković, Sanja
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Jaćević, Vesna
AU  - Durgo, Ksenija
AU  - Antonijević, Biljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1712
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effects of BDE209 and Cd mixture on liver in sub-acutely exposed rats
VL  - 211
IS  - Supplement
SP  - S158
EP  - S158
DO  - 10.1016/j.toxlet.2012.03.574
ER  - 

@conference{
author = "Ćurčić, Marijana and Stanković, Sanja and Janković, Saša and Vučinić, Slavica and Jaćević, Vesna and Durgo, Ksenija and Antonijević, Biljana",
year = "2012",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effects of BDE209 and Cd mixture on liver in sub-acutely exposed rats",
volume = "211",
number = "Supplement",
pages = "S158-S158",
doi = "10.1016/j.toxlet.2012.03.574"
}

Ćurčić, M., Stanković, S., Janković, S., Vučinić, S., Jaćević, V., Durgo, K.,& Antonijević, B.. (2012). Effects of BDE209 and Cd mixture on liver in sub-acutely exposed rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 211(Supplement), S158-S158.
https://doi.org/10.1016/j.toxlet.2012.03.574

Ćurčić M, Stanković S, Janković S, Vučinić S, Jaćević V, Durgo K, Antonijević B. Effects of BDE209 and Cd mixture on liver in sub-acutely exposed rats. in Toxicology Letters. 2012;211(Supplement):S158-S158.
doi:10.1016/j.toxlet.2012.03.574 .

Ćurčić, Marijana, Stanković, Sanja, Janković, Saša, Vučinić, Slavica, Jaćević, Vesna, Durgo, Ksenija, Antonijević, Biljana, "Effects of BDE209 and Cd mixture on liver in sub-acutely exposed rats" in Toxicology Letters, 211, no. Supplement (2012):S158-S158,
https://doi.org/10.1016/j.toxlet.2012.03.574 . .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Jaćević, Vesna
AU  - Stanković, Sanja
AU  - Vučinić, Slavica
AU  - Durgo, Ksenija
AU  - Antonijević, Biljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1786
AB  - In relation to commonly used no-observed-adverse-effect-level (NOAEL) point of departure, because of its statistical power and reliability, Benchmark dose (BMD) approach has been proposed as an alternative in dose-response assessment. The aim of this study was to derive BMD (10%) by means of PROAST software to quantify influence of cadmium (Cd) and/or decabrominated diphenyl ether (BDE209) on thyroid hormones homestasis. Study was conducted on male Wistar rats treated orally by gavage for 28 days by either single substances or their combination. Three groups of animals were dosed with Cd at levels of 2.5, 7.5 and 15 mg/kg b.w./day, three groups of animals were dosed with BDE209 at levels of 1000, 2000 or 4000 mg/kg b.w./day, while 9 groups received different dose mixtures of previously given dose levels of Cd and BDE209 (design 3 x 3). Results of the study have indicated that Cd+BDE209 mixtures are likely more potent to disrupt thyroid function than would be expected from the chemicals individually. Derived BMD - lower confidence limits (BMDL), if ratio BMD/BMDL is  lt  10, were 9.4 mg Cd/kg b.w./day and 2155 mg BDE209/kg b.w./day for the effect on T3; and 6.22 mg Cd/kg b.w./day in the mixture with BDE209 2000 mg/kg b.w./day for the effect on FT3.
AB  - Primena statistički dobijene Benchmark doze (BMD) u proceni rizika predstavlja alternativu najčešće korišćenoj 'dozi bez štetnog efekta' (NOAEL) zbog veće pouzdanosti u analizi odnosa doze i toksičnog efekta. Cilj ovog rada bio je izračunavanje BMD (10%) primenom PROAST softvera radi kvantitativne procene uticaja Cd i/ili BDE209 na homeostazu hormona štitaste žlezde. Ispitivanje je sprovedeno na mužjacima Wistar pacova koji su putem oralne sonde, tokom 28 dana, primali pojedinačne supstance ili njihove kombinacije. Kadmijum je primenjivan u dozama od 2,5, 7,5 i 15 mg Cd/kg t.m./dan, a BDE209 u dozama od 1000, 2000 i 4000 mg BDE209/kg t.m./dan, dok je ostalih devet grupa životinja primalo kombinacije hemikalija (dizajn 3 x 3). Rezultati studije ukazuju da smeša Cd i BDE209 verovatno izaziva intenzivniji poremećaj funkcije štitaste žlezde nego svaka od supstanci pojedinačno. Izračunate Benchmark doze (10%), odnosno odgovarajuće donje granice pouzdanosti (BMDL), uz uslov da je BMD/BMDL  lt  10, iznose 9,4 mg Cd/kg t.m./dan i 2155 mg BDE209/kg t.m./dan za efekte na T3 hormon, a za efekat na FT3 hormon 6,22 mg Cd/kg t.m/dan u smeši sa BDE209 od 2000 mg/kg.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Use of PROAST software to assess the influence of decabrominated diphenyl ether and/or cadmium on thyroid hormones homeostasis in rats
T1  - Primena PROAST softvera za ispitivanje uticaja dekabromovanog difeniletra i/ili kadmijuma na homeostazu hormona štitaste žlezde kod pacova
VL  - 62
IS  - 1
SP  - 1
EP  - 13
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1786
ER  - 

@article{
author = "Ćurčić, Marijana and Janković, Saša and Jaćević, Vesna and Stanković, Sanja and Vučinić, Slavica and Durgo, Ksenija and Antonijević, Biljana",
year = "2012",
abstract = "In relation to commonly used no-observed-adverse-effect-level (NOAEL) point of departure, because of its statistical power and reliability, Benchmark dose (BMD) approach has been proposed as an alternative in dose-response assessment. The aim of this study was to derive BMD (10%) by means of PROAST software to quantify influence of cadmium (Cd) and/or decabrominated diphenyl ether (BDE209) on thyroid hormones homestasis. Study was conducted on male Wistar rats treated orally by gavage for 28 days by either single substances or their combination. Three groups of animals were dosed with Cd at levels of 2.5, 7.5 and 15 mg/kg b.w./day, three groups of animals were dosed with BDE209 at levels of 1000, 2000 or 4000 mg/kg b.w./day, while 9 groups received different dose mixtures of previously given dose levels of Cd and BDE209 (design 3 x 3). Results of the study have indicated that Cd+BDE209 mixtures are likely more potent to disrupt thyroid function than would be expected from the chemicals individually. Derived BMD - lower confidence limits (BMDL), if ratio BMD/BMDL is  lt  10, were 9.4 mg Cd/kg b.w./day and 2155 mg BDE209/kg b.w./day for the effect on T3; and 6.22 mg Cd/kg b.w./day in the mixture with BDE209 2000 mg/kg b.w./day for the effect on FT3., Primena statistički dobijene Benchmark doze (BMD) u proceni rizika predstavlja alternativu najčešće korišćenoj 'dozi bez štetnog efekta' (NOAEL) zbog veće pouzdanosti u analizi odnosa doze i toksičnog efekta. Cilj ovog rada bio je izračunavanje BMD (10%) primenom PROAST softvera radi kvantitativne procene uticaja Cd i/ili BDE209 na homeostazu hormona štitaste žlezde. Ispitivanje je sprovedeno na mužjacima Wistar pacova koji su putem oralne sonde, tokom 28 dana, primali pojedinačne supstance ili njihove kombinacije. Kadmijum je primenjivan u dozama od 2,5, 7,5 i 15 mg Cd/kg t.m./dan, a BDE209 u dozama od 1000, 2000 i 4000 mg BDE209/kg t.m./dan, dok je ostalih devet grupa životinja primalo kombinacije hemikalija (dizajn 3 x 3). Rezultati studije ukazuju da smeša Cd i BDE209 verovatno izaziva intenzivniji poremećaj funkcije štitaste žlezde nego svaka od supstanci pojedinačno. Izračunate Benchmark doze (10%), odnosno odgovarajuće donje granice pouzdanosti (BMDL), uz uslov da je BMD/BMDL  lt  10, iznose 9,4 mg Cd/kg t.m./dan i 2155 mg BDE209/kg t.m./dan za efekte na T3 hormon, a za efekat na FT3 hormon 6,22 mg Cd/kg t.m/dan u smeši sa BDE209 od 2000 mg/kg.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Use of PROAST software to assess the influence of decabrominated diphenyl ether and/or cadmium on thyroid hormones homeostasis in rats, Primena PROAST softvera za ispitivanje uticaja dekabromovanog difeniletra i/ili kadmijuma na homeostazu hormona štitaste žlezde kod pacova",
volume = "62",
number = "1",
pages = "1-13",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1786"
}

Ćurčić, M., Janković, S., Jaćević, V., Stanković, S., Vučinić, S., Durgo, K.,& Antonijević, B.. (2012). Use of PROAST software to assess the influence of decabrominated diphenyl ether and/or cadmium on thyroid hormones homeostasis in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 62(1), 1-13.
https://hdl.handle.net/21.15107/rcub_farfar_1786

Ćurčić M, Janković S, Jaćević V, Stanković S, Vučinić S, Durgo K, Antonijević B. Use of PROAST software to assess the influence of decabrominated diphenyl ether and/or cadmium on thyroid hormones homeostasis in rats. in Arhiv za farmaciju. 2012;62(1):1-13.
https://hdl.handle.net/21.15107/rcub_farfar_1786 .

Ćurčić, Marijana, Janković, Saša, Jaćević, Vesna, Stanković, Sanja, Vučinić, Slavica, Durgo, Ksenija, Antonijević, Biljana, "Use of PROAST software to assess the influence of decabrominated diphenyl ether and/or cadmium on thyroid hormones homeostasis in rats" in Arhiv za farmaciju, 62, no. 1 (2012):1-13,
https://hdl.handle.net/21.15107/rcub_farfar_1786 .

TY  - JOUR
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Jaćević, Vesna
AU  - Stanković, Sanja
AU  - Vučinić, Slavica
AU  - Durgo, Ksenija
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1627
AB  - The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats
VL  - 63
IS  - 3
SP  - 255
EP  - 262
DO  - 10.2478/10004-1254-63-2012-2179
ER  - 

@article{
author = "Ćurčić, Marijana and Janković, Saša and Jaćević, Vesna and Stanković, Sanja and Vučinić, Slavica and Durgo, Ksenija and Bulat, Zorica and Antonijević, Biljana",
year = "2012",
abstract = "The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg(-1), 7.5 mg kg(-1), or 15 mg kg(-1) b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg(-1), 2000 mg kg(-1), or 4000 mg kg(-1) b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats",
volume = "63",
number = "3",
pages = "255-262",
doi = "10.2478/10004-1254-63-2012-2179"
}

Ćurčić, M., Janković, S., Jaćević, V., Stanković, S., Vučinić, S., Durgo, K., Bulat, Z.,& Antonijević, B.. (2012). Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 63(3), 255-262.
https://doi.org/10.2478/10004-1254-63-2012-2179

Ćurčić M, Janković S, Jaćević V, Stanković S, Vučinić S, Durgo K, Bulat Z, Antonijević B. Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2012;63(3):255-262.
doi:10.2478/10004-1254-63-2012-2179 .

Ćurčić, Marijana, Janković, Saša, Jaćević, Vesna, Stanković, Sanja, Vučinić, Slavica, Durgo, Ksenija, Bulat, Zorica, Antonijević, Biljana, "Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 63, no. 3 (2012):255-262,
https://doi.org/10.2478/10004-1254-63-2012-2179 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Stanković, Sanja
AU  - Jaćević, Vesna
AU  - Janković, Saša
AU  - Durgo, Ksenija
AU  - Milovanović, Vesna
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1473
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium
VL  - 205
IS  - Supplement
SP  - S210
EP  - S211
DO  - 10.1016/j.toxlet.2011.05.724
ER  - 

@conference{
author = "Ćurčić, Marijana and Stanković, Sanja and Jaćević, Vesna and Janković, Saša and Durgo, Ksenija and Milovanović, Vesna and Vučinić, Slavica and Antonijević, Biljana",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium",
volume = "205",
number = "Supplement",
pages = "S210-S211",
doi = "10.1016/j.toxlet.2011.05.724"
}

Ćurčić, M., Stanković, S., Jaćević, V., Janković, S., Durgo, K., Milovanović, V., Vučinić, S.,& Antonijević, B.. (2011). Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S210-S211.
https://doi.org/10.1016/j.toxlet.2011.05.724

Ćurčić M, Stanković S, Jaćević V, Janković S, Durgo K, Milovanović V, Vučinić S, Antonijević B. Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium. in Toxicology Letters. 2011;205(Supplement):S210-S211.
doi:10.1016/j.toxlet.2011.05.724 .

Ćurčić, Marijana, Stanković, Sanja, Jaćević, Vesna, Janković, Saša, Durgo, Ksenija, Milovanović, Vesna, Vučinić, Slavica, Antonijević, Biljana, "Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium" in Toxicology Letters, 205, no. Supplement (2011):S210-S211,
https://doi.org/10.1016/j.toxlet.2011.05.724 . .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Jaćević, Vesna
AU  - Stanković, Sanja
AU  - Janković, Saša
AU  - Durgo, Ksenija
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1474
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effects of BDE 209 and cadmium mixture on thyroid hormone levels in rats
VL  - 205
IS  - Supplement
SP  - S211
EP  - S211
DO  - 10.1016/j.toxlet.2011.05.725
ER  - 

@conference{
author = "Ćurčić, Marijana and Jaćević, Vesna and Stanković, Sanja and Janković, Saša and Durgo, Ksenija and Vučinić, Slavica and Antonijević, Biljana",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effects of BDE 209 and cadmium mixture on thyroid hormone levels in rats",
volume = "205",
number = "Supplement",
pages = "S211-S211",
doi = "10.1016/j.toxlet.2011.05.725"
}

Ćurčić, M., Jaćević, V., Stanković, S., Janković, S., Durgo, K., Vučinić, S.,& Antonijević, B.. (2011). Effects of BDE 209 and cadmium mixture on thyroid hormone levels in rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S211-S211.
https://doi.org/10.1016/j.toxlet.2011.05.725

Ćurčić M, Jaćević V, Stanković S, Janković S, Durgo K, Vučinić S, Antonijević B. Effects of BDE 209 and cadmium mixture on thyroid hormone levels in rats. in Toxicology Letters. 2011;205(Supplement):S211-S211.
doi:10.1016/j.toxlet.2011.05.725 .

Ćurčić, Marijana, Jaćević, Vesna, Stanković, Sanja, Janković, Saša, Durgo, Ksenija, Vučinić, Slavica, Antonijević, Biljana, "Effects of BDE 209 and cadmium mixture on thyroid hormone levels in rats" in Toxicology Letters, 205, no. Supplement (2011):S211-S211,
https://doi.org/10.1016/j.toxlet.2011.05.725 . .