TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Petricević, Sasa M.
AU  - Ristić, Slavica M.
AU  - Ibrić, Svetlana
AU  - Simić, Slobodanka
AU  - Đurić, Zorica
AU  - Popović, Radmila
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2002
AB  - Objective: The suitability of the rabbit as an animal model for the primary screening and selection of the pilot scale batches during the early stages of the formulation development was studied. Materials and methods: Three modified-release formulations of aminophylline consisted of Carbopol (R) 971P/HPMC K4M (F-I), and HPMC K100M (F-II) or HPMC K4M (F-III) were used. Commercial products were Aminofilin retard 350 mg tablets, Srbolek, Serbia (R-I) and Phyllocontin (R) 350, tablets Purdue Frederic, Canada (R-II). Results: Calculated release rate constants and the f2 values between R-I/F-I (84.1) and R-II/F-III (83.4) indicated similar in vitro release while the coefficient n showed presence of different mechanisms of release from Anomalous transport, Fickian diffusion to Case-II transport. Higher T-max, was found in the rabbits, dosed with F-II (12.00 h), F-III (10.50 h), and R-II (15.00 h) formulation. The highest C-max (9.22 mg/L) was obtained with F-II, similar lower values was seen for F-I and F-III, while commercial products showed the lowest values R-I (5.58 mg/L) and R-II (4.18 mg/L). Higher AUC values were detected for all three formulations (from 115.90 to 204.06 mgh/L) in relation to commercial products (105.33 and 113.25 mgh/L). Discussion and conclusion: The results demonstrated a good correlation of Level A (r(2) = 0.97) for the two formulations (F-I, F-III) and commercial product (R-I) indicates that there is a reasonable assumption that the rabbit might be use as a model for the preliminary comparison of scale up formulations in the early stages of the product development.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms
VL  - 39
IS  - 6
SP  - 889
EP  - 900
DO  - 10.3109/03639045.2012.713364
ER  - 

@article{
author = "Petrović, Aleksandra and Petricević, Sasa M. and Ristić, Slavica M. and Ibrić, Svetlana and Simić, Slobodanka and Đurić, Zorica and Popović, Radmila",
year = "2013",
abstract = "Objective: The suitability of the rabbit as an animal model for the primary screening and selection of the pilot scale batches during the early stages of the formulation development was studied. Materials and methods: Three modified-release formulations of aminophylline consisted of Carbopol (R) 971P/HPMC K4M (F-I), and HPMC K100M (F-II) or HPMC K4M (F-III) were used. Commercial products were Aminofilin retard 350 mg tablets, Srbolek, Serbia (R-I) and Phyllocontin (R) 350, tablets Purdue Frederic, Canada (R-II). Results: Calculated release rate constants and the f2 values between R-I/F-I (84.1) and R-II/F-III (83.4) indicated similar in vitro release while the coefficient n showed presence of different mechanisms of release from Anomalous transport, Fickian diffusion to Case-II transport. Higher T-max, was found in the rabbits, dosed with F-II (12.00 h), F-III (10.50 h), and R-II (15.00 h) formulation. The highest C-max (9.22 mg/L) was obtained with F-II, similar lower values was seen for F-I and F-III, while commercial products showed the lowest values R-I (5.58 mg/L) and R-II (4.18 mg/L). Higher AUC values were detected for all three formulations (from 115.90 to 204.06 mgh/L) in relation to commercial products (105.33 and 113.25 mgh/L). Discussion and conclusion: The results demonstrated a good correlation of Level A (r(2) = 0.97) for the two formulations (F-I, F-III) and commercial product (R-I) indicates that there is a reasonable assumption that the rabbit might be use as a model for the preliminary comparison of scale up formulations in the early stages of the product development.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms",
volume = "39",
number = "6",
pages = "889-900",
doi = "10.3109/03639045.2012.713364"
}

Petrović, A., Petricević, S. M., Ristić, S. M., Ibrić, S., Simić, S., Đurić, Z.,& Popović, R.. (2013). Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 39(6), 889-900.
https://doi.org/10.3109/03639045.2012.713364

Petrović A, Petricević SM, Ristić SM, Ibrić S, Simić S, Đurić Z, Popović R. Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms. in Drug Development and Industrial Pharmacy. 2013;39(6):889-900.
doi:10.3109/03639045.2012.713364 .

Petrović, Aleksandra, Petricević, Sasa M., Ristić, Slavica M., Ibrić, Svetlana, Simić, Slobodanka, Đurić, Zorica, Popović, Radmila, "Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms" in Drug Development and Industrial Pharmacy, 39, no. 6 (2013):889-900,
https://doi.org/10.3109/03639045.2012.713364 . .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Popović, Radmila
AU  - Đurić, Zorica
AU  - Popadić, Dragica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1284
AB  - The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design
VL  - 32
IS  - 7
SP  - 1087
EP  - 1096
DO  - 10.1007/s12272-009-1715-y
ER  - 

@article{
author = "Petrović, Aleksandra and Ibrić, Svetlana and Trajković, Svetlana and Popović, Radmila and Đurić, Zorica and Popadić, Dragica",
year = "2009",
abstract = "The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design",
volume = "32",
number = "7",
pages = "1087-1096",
doi = "10.1007/s12272-009-1715-y"
}

Petrović, A., Ibrić, S., Trajković, S., Popović, R., Đurić, Z.,& Popadić, D.. (2009). An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(7), 1087-1096.
https://doi.org/10.1007/s12272-009-1715-y

Petrović A, Ibrić S, Trajković S, Popović R, Đurić Z, Popadić D. An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research. 2009;32(7):1087-1096.
doi:10.1007/s12272-009-1715-y .

Petrović, Aleksandra, Ibrić, Svetlana, Trajković, Svetlana, Popović, Radmila, Đurić, Zorica, Popadić, Dragica, "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design" in Archives of Pharmacal Research, 32, no. 7 (2009):1087-1096,
https://doi.org/10.1007/s12272-009-1715-y . .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Đurić, Zorica
AU  - Popadić, Dragica
AU  - Popović, Radmila
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1191
AB  - Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose
VL  - 32
IS  - 12
SP  - 1767
EP  - 1774
DO  - 10.1007/s12272-009-2215-9
ER  - 

@article{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Ibrić, Svetlana and Trajković, Svetlana and Đurić, Zorica and Popadić, Dragica and Popović, Radmila",
year = "2009",
abstract = "Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose",
volume = "32",
number = "12",
pages = "1767-1774",
doi = "10.1007/s12272-009-2215-9"
}

Petrović, A., Cvetković, N., Ibrić, S., Trajković, S., Đurić, Z., Popadić, D.,& Popović, R.. (2009). Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(12), 1767-1774.
https://doi.org/10.1007/s12272-009-2215-9

Petrović A, Cvetković N, Ibrić S, Trajković S, Đurić Z, Popadić D, Popović R. Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. in Archives of Pharmacal Research. 2009;32(12):1767-1774.
doi:10.1007/s12272-009-2215-9 .

Petrović, Aleksandra, Cvetković, Nebojša, Ibrić, Svetlana, Trajković, Svetlana, Đurić, Zorica, Popadić, Dragica, Popović, Radmila, "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose" in Archives of Pharmacal Research, 32, no. 12 (2009):1767-1774,
https://doi.org/10.1007/s12272-009-2215-9 . .