TY  - JOUR
AU  - Puvača, Nikola
AU  - Milenković, Jovana
AU  - Galonja Coghill, Tamara
AU  - Bursić, Vojislava
AU  - Petrović, Aleksandra
AU  - Tanasković, Snežana
AU  - Pelić, Miloš
AU  - Ljubojević Pelić, Dragana
AU  - Miljković, Tatjana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3907
AB  - The worldwide problem of infectious diseases has appeared in recent years, and antimicrobial agents are crucial in reducing disease emergence. Nevertheless, the development and distribution of multidrug-resistant (MDR) strains in pathogenic bacteria, such as Escherichia coli, Staphylococcus aureus, Salmonella Typhi and Citrobacter koseri, has become a major society health hazard. Essential oils could serve as a promising tool as a natural drug in fighting the problem with these bacteria. The current study aimed to investigate the antimicrobial effectiveness of tea tree (Melaleuca alternifolia (Maiden and Betche) Cheel), rosemary (Rosmarinus officinalis L.), eucalyptus (Eucalyptus obliqua L’Hér.), and lavender (Lavandula angustifolia Mill) essential oils. The antimicrobial properties of essential oils were screened against four pathogenic bacteria, E. coli, S. aureus, S. Tyhpi, and C. koseri, and two reference bacterial strains, while for the testing, the agar well diffusion method was used. Gas chromatography (GC) and gas chromatography–mass spectrometric (GC–MSD) analyses were performed on essential oils. The obtained results showed that M. alternifolia essential oil is the richest in terpinen-4-ol, R. officinalis and E. oblique essential oils in 1,8-cineole, and L. angustifolia essential oil in α-terpinyl acetate. In addition, the main bioactive compounds present in the essential oil of tea tree are rich in α-pinene (18.38%), limonene (7.55%) and γ-terpinene (14.01%). The essential oil of rosemary is rich in α-pinene (8.38%) and limonene (11.86%); eucalyptus essential oil has significant concentrations of α-pinene (12.60%), p-cymene (3.24%), limonene (3.87%), and γ-terpinene (7.37%), while the essential oil of lavender is rich in linalool (10.71%), linalool acetate (9.60%), α-terpinyl acetate (10.93%), and carbitol (13.05%) bioactive compounds, respectively. The obtained results from the in vitro study revealed that most of the essential oils exhibited antimicrobial properties. Among the tested essential oils, tea tree was discovered to demonstrate the strongest antimicrobial activity. The recorded MIC of S. Typhi was 6.2 mg/mL, 3.4 mg/mL of C. koseri, 3.1 mg/mL of E. coli, and 2.7 mg/mL of E. coli ATCC 25922, compared to M. alternifolia. Similarly, only S. aureus ATCC 25923 showed antimicrobial activity towards R. officinalis (1.4 mg/mL), E. oblique (2.9 mg/mL), and L. angustifolia (2.1 mg/mL). Based on the obtained results, it is possible to conclude that tea tree essential oil might be used as an ecological antimicrobial in treating infectious diseases caused by the tested pathogens.
PB  - MDPI AG
T2  - Antibiotics
T1  - Antimicrobial activity of selected essential oils against selected pathogenic bacteria: In vitro study
VL  - 10
IS  - 5
DO  - 10.3390/antibiotics10050546
ER  - 

@article{
author = "Puvača, Nikola and Milenković, Jovana and Galonja Coghill, Tamara and Bursić, Vojislava and Petrović, Aleksandra and Tanasković, Snežana and Pelić, Miloš and Ljubojević Pelić, Dragana and Miljković, Tatjana",
year = "2021",
abstract = "The worldwide problem of infectious diseases has appeared in recent years, and antimicrobial agents are crucial in reducing disease emergence. Nevertheless, the development and distribution of multidrug-resistant (MDR) strains in pathogenic bacteria, such as Escherichia coli, Staphylococcus aureus, Salmonella Typhi and Citrobacter koseri, has become a major society health hazard. Essential oils could serve as a promising tool as a natural drug in fighting the problem with these bacteria. The current study aimed to investigate the antimicrobial effectiveness of tea tree (Melaleuca alternifolia (Maiden and Betche) Cheel), rosemary (Rosmarinus officinalis L.), eucalyptus (Eucalyptus obliqua L’Hér.), and lavender (Lavandula angustifolia Mill) essential oils. The antimicrobial properties of essential oils were screened against four pathogenic bacteria, E. coli, S. aureus, S. Tyhpi, and C. koseri, and two reference bacterial strains, while for the testing, the agar well diffusion method was used. Gas chromatography (GC) and gas chromatography–mass spectrometric (GC–MSD) analyses were performed on essential oils. The obtained results showed that M. alternifolia essential oil is the richest in terpinen-4-ol, R. officinalis and E. oblique essential oils in 1,8-cineole, and L. angustifolia essential oil in α-terpinyl acetate. In addition, the main bioactive compounds present in the essential oil of tea tree are rich in α-pinene (18.38%), limonene (7.55%) and γ-terpinene (14.01%). The essential oil of rosemary is rich in α-pinene (8.38%) and limonene (11.86%); eucalyptus essential oil has significant concentrations of α-pinene (12.60%), p-cymene (3.24%), limonene (3.87%), and γ-terpinene (7.37%), while the essential oil of lavender is rich in linalool (10.71%), linalool acetate (9.60%), α-terpinyl acetate (10.93%), and carbitol (13.05%) bioactive compounds, respectively. The obtained results from the in vitro study revealed that most of the essential oils exhibited antimicrobial properties. Among the tested essential oils, tea tree was discovered to demonstrate the strongest antimicrobial activity. The recorded MIC of S. Typhi was 6.2 mg/mL, 3.4 mg/mL of C. koseri, 3.1 mg/mL of E. coli, and 2.7 mg/mL of E. coli ATCC 25922, compared to M. alternifolia. Similarly, only S. aureus ATCC 25923 showed antimicrobial activity towards R. officinalis (1.4 mg/mL), E. oblique (2.9 mg/mL), and L. angustifolia (2.1 mg/mL). Based on the obtained results, it is possible to conclude that tea tree essential oil might be used as an ecological antimicrobial in treating infectious diseases caused by the tested pathogens.",
publisher = "MDPI AG",
journal = "Antibiotics",
title = "Antimicrobial activity of selected essential oils against selected pathogenic bacteria: In vitro study",
volume = "10",
number = "5",
doi = "10.3390/antibiotics10050546"
}

Puvača, N., Milenković, J., Galonja Coghill, T., Bursić, V., Petrović, A., Tanasković, S., Pelić, M., Ljubojević Pelić, D.,& Miljković, T.. (2021). Antimicrobial activity of selected essential oils against selected pathogenic bacteria: In vitro study. in Antibiotics
MDPI AG., 10(5).
https://doi.org/10.3390/antibiotics10050546

Puvača N, Milenković J, Galonja Coghill T, Bursić V, Petrović A, Tanasković S, Pelić M, Ljubojević Pelić D, Miljković T. Antimicrobial activity of selected essential oils against selected pathogenic bacteria: In vitro study. in Antibiotics. 2021;10(5).
doi:10.3390/antibiotics10050546 .

Puvača, Nikola, Milenković, Jovana, Galonja Coghill, Tamara, Bursić, Vojislava, Petrović, Aleksandra, Tanasković, Snežana, Pelić, Miloš, Ljubojević Pelić, Dragana, Miljković, Tatjana, "Antimicrobial activity of selected essential oils against selected pathogenic bacteria: In vitro study" in Antibiotics, 10, no. 5 (2021),
https://doi.org/10.3390/antibiotics10050546 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Petrović, Aleksandra
AU  - Janković, M.
AU  - Pejin, Boris
AU  - Vajs, Vlatka
AU  - Čakar, Mira
AU  - Đorđević, Brižita
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3173
AB  - Introduction - Fruit and their products, including fruit wines, represent a rich source of natural bioactive compounds. This study focusing on fruit wines (prepared from commercially grown fruits by Serbian producers) has included the investigation of their chemical composition and biological activity. Materials and methods - Black chokeberry, blueberry, raspberry, blackberry and cherry were used for wine production by innovative vinification procedure, with or without using sugar and enzymatic preparation glycosidase, respectively. Selected phenolics were identified and quantified by UPLC/MS-MS analysis, while Total Phenolic Content (TPC) was determined by the Folin-Ciocalteu method. In addition to this, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and FRAP (Ferric Reducing Ability of Plasma) methods were applied for the preliminary evaluation of anti-DPPH radical activity and redox potential respectively at in vitro conditions. Results and discussion - Among the fruit wines examined within this study, the blackberry one stood out for profound FRAP (115.23 mmol L-1 Fe2+), DPPH (1.11%) and TPC values (2,395 mg GAE L-1). On the other hand, the raspberry wine showed the lowest potential towards the aforementioned parameters. Using principal component analysis, these fruit wines were chemically differentiated, according to the predominant phenolic compounds. Conclusions - All fruit wine samples displayed a good antioxidant potential with the blackberry one being most potent. Such a finding is of particular importance for Serbia as one of the leading producers of this edible fruit both in Europe and rest of the world.
PB  - Int Soc Horticultural Science-Ishs, Leuven
T2  - European Journal of Horticultural Science
T1  - Differentiation of wines made from berry and drupe fruits according to their phenolic profiles
VL  - 83
IS  - 1
SP  - 49
EP  - 61
DO  - 10.17660/eJHS.2018/83.1.7
ER  - 

@article{
author = "Čakar, Uroš and Petrović, Aleksandra and Janković, M. and Pejin, Boris and Vajs, Vlatka and Čakar, Mira and Đorđević, Brižita",
year = "2018",
abstract = "Introduction - Fruit and their products, including fruit wines, represent a rich source of natural bioactive compounds. This study focusing on fruit wines (prepared from commercially grown fruits by Serbian producers) has included the investigation of their chemical composition and biological activity. Materials and methods - Black chokeberry, blueberry, raspberry, blackberry and cherry were used for wine production by innovative vinification procedure, with or without using sugar and enzymatic preparation glycosidase, respectively. Selected phenolics were identified and quantified by UPLC/MS-MS analysis, while Total Phenolic Content (TPC) was determined by the Folin-Ciocalteu method. In addition to this, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and FRAP (Ferric Reducing Ability of Plasma) methods were applied for the preliminary evaluation of anti-DPPH radical activity and redox potential respectively at in vitro conditions. Results and discussion - Among the fruit wines examined within this study, the blackberry one stood out for profound FRAP (115.23 mmol L-1 Fe2+), DPPH (1.11%) and TPC values (2,395 mg GAE L-1). On the other hand, the raspberry wine showed the lowest potential towards the aforementioned parameters. Using principal component analysis, these fruit wines were chemically differentiated, according to the predominant phenolic compounds. Conclusions - All fruit wine samples displayed a good antioxidant potential with the blackberry one being most potent. Such a finding is of particular importance for Serbia as one of the leading producers of this edible fruit both in Europe and rest of the world.",
publisher = "Int Soc Horticultural Science-Ishs, Leuven",
journal = "European Journal of Horticultural Science",
title = "Differentiation of wines made from berry and drupe fruits according to their phenolic profiles",
volume = "83",
number = "1",
pages = "49-61",
doi = "10.17660/eJHS.2018/83.1.7"
}

Čakar, U., Petrović, A., Janković, M., Pejin, B., Vajs, V., Čakar, M.,& Đorđević, B.. (2018). Differentiation of wines made from berry and drupe fruits according to their phenolic profiles. in European Journal of Horticultural Science
Int Soc Horticultural Science-Ishs, Leuven., 83(1), 49-61.
https://doi.org/10.17660/eJHS.2018/83.1.7

Čakar U, Petrović A, Janković M, Pejin B, Vajs V, Čakar M, Đorđević B. Differentiation of wines made from berry and drupe fruits according to their phenolic profiles. in European Journal of Horticultural Science. 2018;83(1):49-61.
doi:10.17660/eJHS.2018/83.1.7 .

Čakar, Uroš, Petrović, Aleksandra, Janković, M., Pejin, Boris, Vajs, Vlatka, Čakar, Mira, Đorđević, Brižita, "Differentiation of wines made from berry and drupe fruits according to their phenolic profiles" in European Journal of Horticultural Science, 83, no. 1 (2018):49-61,
https://doi.org/10.17660/eJHS.2018/83.1.7 . .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Petricević, Sasa M.
AU  - Ristić, Slavica M.
AU  - Ibrić, Svetlana
AU  - Simić, Slobodanka
AU  - Đurić, Zorica
AU  - Popović, Radmila
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2002
AB  - Objective: The suitability of the rabbit as an animal model for the primary screening and selection of the pilot scale batches during the early stages of the formulation development was studied. Materials and methods: Three modified-release formulations of aminophylline consisted of Carbopol (R) 971P/HPMC K4M (F-I), and HPMC K100M (F-II) or HPMC K4M (F-III) were used. Commercial products were Aminofilin retard 350 mg tablets, Srbolek, Serbia (R-I) and Phyllocontin (R) 350, tablets Purdue Frederic, Canada (R-II). Results: Calculated release rate constants and the f2 values between R-I/F-I (84.1) and R-II/F-III (83.4) indicated similar in vitro release while the coefficient n showed presence of different mechanisms of release from Anomalous transport, Fickian diffusion to Case-II transport. Higher T-max, was found in the rabbits, dosed with F-II (12.00 h), F-III (10.50 h), and R-II (15.00 h) formulation. The highest C-max (9.22 mg/L) was obtained with F-II, similar lower values was seen for F-I and F-III, while commercial products showed the lowest values R-I (5.58 mg/L) and R-II (4.18 mg/L). Higher AUC values were detected for all three formulations (from 115.90 to 204.06 mgh/L) in relation to commercial products (105.33 and 113.25 mgh/L). Discussion and conclusion: The results demonstrated a good correlation of Level A (r(2) = 0.97) for the two formulations (F-I, F-III) and commercial product (R-I) indicates that there is a reasonable assumption that the rabbit might be use as a model for the preliminary comparison of scale up formulations in the early stages of the product development.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms
VL  - 39
IS  - 6
SP  - 889
EP  - 900
DO  - 10.3109/03639045.2012.713364
ER  - 

@article{
author = "Petrović, Aleksandra and Petricević, Sasa M. and Ristić, Slavica M. and Ibrić, Svetlana and Simić, Slobodanka and Đurić, Zorica and Popović, Radmila",
year = "2013",
abstract = "Objective: The suitability of the rabbit as an animal model for the primary screening and selection of the pilot scale batches during the early stages of the formulation development was studied. Materials and methods: Three modified-release formulations of aminophylline consisted of Carbopol (R) 971P/HPMC K4M (F-I), and HPMC K100M (F-II) or HPMC K4M (F-III) were used. Commercial products were Aminofilin retard 350 mg tablets, Srbolek, Serbia (R-I) and Phyllocontin (R) 350, tablets Purdue Frederic, Canada (R-II). Results: Calculated release rate constants and the f2 values between R-I/F-I (84.1) and R-II/F-III (83.4) indicated similar in vitro release while the coefficient n showed presence of different mechanisms of release from Anomalous transport, Fickian diffusion to Case-II transport. Higher T-max, was found in the rabbits, dosed with F-II (12.00 h), F-III (10.50 h), and R-II (15.00 h) formulation. The highest C-max (9.22 mg/L) was obtained with F-II, similar lower values was seen for F-I and F-III, while commercial products showed the lowest values R-I (5.58 mg/L) and R-II (4.18 mg/L). Higher AUC values were detected for all three formulations (from 115.90 to 204.06 mgh/L) in relation to commercial products (105.33 and 113.25 mgh/L). Discussion and conclusion: The results demonstrated a good correlation of Level A (r(2) = 0.97) for the two formulations (F-I, F-III) and commercial product (R-I) indicates that there is a reasonable assumption that the rabbit might be use as a model for the preliminary comparison of scale up formulations in the early stages of the product development.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms",
volume = "39",
number = "6",
pages = "889-900",
doi = "10.3109/03639045.2012.713364"
}

Petrović, A., Petricević, S. M., Ristić, S. M., Ibrić, S., Simić, S., Đurić, Z.,& Popović, R.. (2013). Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 39(6), 889-900.
https://doi.org/10.3109/03639045.2012.713364

Petrović A, Petricević SM, Ristić SM, Ibrić S, Simić S, Đurić Z, Popović R. Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms. in Drug Development and Industrial Pharmacy. 2013;39(6):889-900.
doi:10.3109/03639045.2012.713364 .

Petrović, Aleksandra, Petricević, Sasa M., Ristić, Slavica M., Ibrić, Svetlana, Simić, Slobodanka, Đurić, Zorica, Popović, Radmila, "Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms" in Drug Development and Industrial Pharmacy, 39, no. 6 (2013):889-900,
https://doi.org/10.3109/03639045.2012.713364 . .

TY  - JOUR
AU  - Ivić, Branka
AU  - Ibrić, Svetlana
AU  - Cvetković, Nebojša
AU  - Petrović, Aleksandra
AU  - Trajković, Svetlana
AU  - Đurić, Zorica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1401
AB  - The purpose of the study was to screen the effects of formulation factors on the in vitro release profile of diclofenac sodium from matrix tablets using design of experiment (DOE). Formulations of diclofenac sodium tablets, with Carbopol (R) 71G as matrix substance, were optimized by artificial neural network. According to Central Composite Design, 10 formulations of diclofenac sodium matrix tablets were prepared. As network inputs, concentration of Carbopol (R) 71G and the Kollidon (R) K-25 were selected. In vitro dissolution time profiles at 5 different sampling times were chosen as responses. The independent variables and the release parameters were processed by multilayer perceptrons neural network (MLP). Results of drug release studies indicate that drug release rates vary between different formulations, with a range of 1 h to more than 8 h to complete dissolution. For two tested formulations there was no difference between experimental and MLP predicted in vitro profiles. The M LP model was optimized. The root mean square value for the trained network was 0.07%, which indicated that the optimal MLP model was reached. The optimal tablet formulation predicted by MLP was with 23% of Carbopol (R) 710 and 0.8% of Kollidon (R) K-25. Calculated difference factor (f(1) 7.37) and similarity factor (f(2) 70.79) indicate that there is no difference between predicted and experimentally observed drug release profiles for the optimal formulation. The satisfactory prediction of drug release for optimal formulation by the MLP in this study has shown the applicability of this optimization method in modeling extended release tablet formulation.
PB  - Pharmaceutical Soc Japan, Tokyo
T2  - Chemical & Pharmaceutical Bulletin
T1  - Application of Design of Experiments and Multilayer Perceptrons Neural Network in the Optimization of Diclofenac Sodium Extended Release Tablets with Carbopol (R) 71G
VL  - 58
IS  - 7
SP  - 947
EP  - 949
DO  - 10.1248/cpb.58.947
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1401
ER  - 

@article{
author = "Ivić, Branka and Ibrić, Svetlana and Cvetković, Nebojša and Petrović, Aleksandra and Trajković, Svetlana and Đurić, Zorica",
year = "2010",
abstract = "The purpose of the study was to screen the effects of formulation factors on the in vitro release profile of diclofenac sodium from matrix tablets using design of experiment (DOE). Formulations of diclofenac sodium tablets, with Carbopol (R) 71G as matrix substance, were optimized by artificial neural network. According to Central Composite Design, 10 formulations of diclofenac sodium matrix tablets were prepared. As network inputs, concentration of Carbopol (R) 71G and the Kollidon (R) K-25 were selected. In vitro dissolution time profiles at 5 different sampling times were chosen as responses. The independent variables and the release parameters were processed by multilayer perceptrons neural network (MLP). Results of drug release studies indicate that drug release rates vary between different formulations, with a range of 1 h to more than 8 h to complete dissolution. For two tested formulations there was no difference between experimental and MLP predicted in vitro profiles. The M LP model was optimized. The root mean square value for the trained network was 0.07%, which indicated that the optimal MLP model was reached. The optimal tablet formulation predicted by MLP was with 23% of Carbopol (R) 710 and 0.8% of Kollidon (R) K-25. Calculated difference factor (f(1) 7.37) and similarity factor (f(2) 70.79) indicate that there is no difference between predicted and experimentally observed drug release profiles for the optimal formulation. The satisfactory prediction of drug release for optimal formulation by the MLP in this study has shown the applicability of this optimization method in modeling extended release tablet formulation.",
publisher = "Pharmaceutical Soc Japan, Tokyo",
journal = "Chemical & Pharmaceutical Bulletin",
title = "Application of Design of Experiments and Multilayer Perceptrons Neural Network in the Optimization of Diclofenac Sodium Extended Release Tablets with Carbopol (R) 71G",
volume = "58",
number = "7",
pages = "947-949",
doi = "10.1248/cpb.58.947",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1401"
}

Ivić, B., Ibrić, S., Cvetković, N., Petrović, A., Trajković, S.,& Đurić, Z.. (2010). Application of Design of Experiments and Multilayer Perceptrons Neural Network in the Optimization of Diclofenac Sodium Extended Release Tablets with Carbopol (R) 71G. in Chemical & Pharmaceutical Bulletin
Pharmaceutical Soc Japan, Tokyo., 58(7), 947-949.
https://doi.org/10.1248/cpb.58.947
https://hdl.handle.net/21.15107/rcub_farfar_1401

Ivić B, Ibrić S, Cvetković N, Petrović A, Trajković S, Đurić Z. Application of Design of Experiments and Multilayer Perceptrons Neural Network in the Optimization of Diclofenac Sodium Extended Release Tablets with Carbopol (R) 71G. in Chemical & Pharmaceutical Bulletin. 2010;58(7):947-949.
doi:10.1248/cpb.58.947
https://hdl.handle.net/21.15107/rcub_farfar_1401 .

Ivić, Branka, Ibrić, Svetlana, Cvetković, Nebojša, Petrović, Aleksandra, Trajković, Svetlana, Đurić, Zorica, "Application of Design of Experiments and Multilayer Perceptrons Neural Network in the Optimization of Diclofenac Sodium Extended Release Tablets with Carbopol (R) 71G" in Chemical & Pharmaceutical Bulletin, 58, no. 7 (2010):947-949,
https://doi.org/10.1248/cpb.58.947 .,
https://hdl.handle.net/21.15107/rcub_farfar_1401 .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Popović, Radmila
AU  - Đurić, Zorica
AU  - Popadić, Dragica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1284
AB  - The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design
VL  - 32
IS  - 7
SP  - 1087
EP  - 1096
DO  - 10.1007/s12272-009-1715-y
ER  - 

@article{
author = "Petrović, Aleksandra and Ibrić, Svetlana and Trajković, Svetlana and Popović, Radmila and Đurić, Zorica and Popadić, Dragica",
year = "2009",
abstract = "The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design",
volume = "32",
number = "7",
pages = "1087-1096",
doi = "10.1007/s12272-009-1715-y"
}

Petrović, A., Ibrić, S., Trajković, S., Popović, R., Đurić, Z.,& Popadić, D.. (2009). An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(7), 1087-1096.
https://doi.org/10.1007/s12272-009-1715-y

Petrović A, Ibrić S, Trajković S, Popović R, Đurić Z, Popadić D. An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research. 2009;32(7):1087-1096.
doi:10.1007/s12272-009-1715-y .

Petrović, Aleksandra, Ibrić, Svetlana, Trajković, Svetlana, Popović, Radmila, Đurić, Zorica, Popadić, Dragica, "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design" in Archives of Pharmacal Research, 32, no. 7 (2009):1087-1096,
https://doi.org/10.1007/s12272-009-1715-y . .

TY  - JOUR
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Đurić, Zorica
AU  - Popadić, Dragica
AU  - Popović, Radmila
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1191
AB  - Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
PB  - Pharmaceutical Soc Korea, Seoul
T2  - Archives of Pharmacal Research
T1  - Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose
VL  - 32
IS  - 12
SP  - 1767
EP  - 1774
DO  - 10.1007/s12272-009-2215-9
ER  - 

@article{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Ibrić, Svetlana and Trajković, Svetlana and Đurić, Zorica and Popadić, Dragica and Popović, Radmila",
year = "2009",
abstract = "Using mixture experimental design, the effect of carbomer (Carbopole (R) 971P NF) and hydroxypropylmethylcellulose (Methocel (R) K100M or Methocel (R) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.",
publisher = "Pharmaceutical Soc Korea, Seoul",
journal = "Archives of Pharmacal Research",
title = "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose",
volume = "32",
number = "12",
pages = "1767-1774",
doi = "10.1007/s12272-009-2215-9"
}

Petrović, A., Cvetković, N., Ibrić, S., Trajković, S., Đurić, Z., Popadić, D.,& Popović, R.. (2009). Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. in Archives of Pharmacal Research
Pharmaceutical Soc Korea, Seoul., 32(12), 1767-1774.
https://doi.org/10.1007/s12272-009-2215-9

Petrović A, Cvetković N, Ibrić S, Trajković S, Đurić Z, Popadić D, Popović R. Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose. in Archives of Pharmacal Research. 2009;32(12):1767-1774.
doi:10.1007/s12272-009-2215-9 .

Petrović, Aleksandra, Cvetković, Nebojša, Ibrić, Svetlana, Trajković, Svetlana, Đurić, Zorica, Popadić, Dragica, Popović, Radmila, "Application of Mixture Experimental Design in the Formulation and Optimization of Matrix Tablets Containing Carbomer and Hydroxypropylmethylcellulose" in Archives of Pharmacal Research, 32, no. 12 (2009):1767-1774,
https://doi.org/10.1007/s12272-009-2215-9 . .

TY  - CONF
AU  - Ivić, Branka
AU  - Cvetković, Nebojša
AU  - Ibrić, Svetlana
AU  - Petrović, Aleksandra
AU  - Trajković, Svetlana
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/796
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The influence of different factors on diclofenac sodium release from extended release matrices
T1  - Uticaj različitih faktora na oslobađanje diklofenak natrijuma iz matriks tableta sa produženim oslobađanjem
VL  - 56
IS  - 4
SP  - 474
EP  - 475
UR  - https://hdl.handle.net/21.15107/rcub_farfar_796
ER  - 

@conference{
author = "Ivić, Branka and Cvetković, Nebojša and Ibrić, Svetlana and Petrović, Aleksandra and Trajković, Svetlana and Đurić, Zorica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The influence of different factors on diclofenac sodium release from extended release matrices, Uticaj različitih faktora na oslobađanje diklofenak natrijuma iz matriks tableta sa produženim oslobađanjem",
volume = "56",
number = "4",
pages = "474-475",
url = "https://hdl.handle.net/21.15107/rcub_farfar_796"
}

Ivić, B., Cvetković, N., Ibrić, S., Petrović, A., Trajković, S.,& Đurić, Z.. (2006). The influence of different factors on diclofenac sodium release from extended release matrices. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 474-475.
https://hdl.handle.net/21.15107/rcub_farfar_796

Ivić B, Cvetković N, Ibrić S, Petrović A, Trajković S, Đurić Z. The influence of different factors on diclofenac sodium release from extended release matrices. in Arhiv za farmaciju. 2006;56(4):474-475.
https://hdl.handle.net/21.15107/rcub_farfar_796 .

Ivić, Branka, Cvetković, Nebojša, Ibrić, Svetlana, Petrović, Aleksandra, Trajković, Svetlana, Đurić, Zorica, "The influence of different factors on diclofenac sodium release from extended release matrices" in Arhiv za farmaciju, 56, no. 4 (2006):474-475,
https://hdl.handle.net/21.15107/rcub_farfar_796 .

TY  - CONF
AU  - Petrović, Aleksandra
AU  - Raić, M.
AU  - Trajković, Svetlana
AU  - Ibrić, Svetlana
AU  - Popović, R.
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/787
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Effect of film coating and storage conditions on tablets quality with moisture sensitive drug
T1  - Uticaj film obloge i uslova čuvanja na kvalitet tableta sa aktivnom supstancom osetljivom na vlagu
VL  - 56
IS  - 4
SP  - 458
EP  - 459
UR  - https://hdl.handle.net/21.15107/rcub_farfar_787
ER  - 

@conference{
author = "Petrović, Aleksandra and Raić, M. and Trajković, Svetlana and Ibrić, Svetlana and Popović, R. and Popadić, Dragica and Đurić, Zorica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Effect of film coating and storage conditions on tablets quality with moisture sensitive drug, Uticaj film obloge i uslova čuvanja na kvalitet tableta sa aktivnom supstancom osetljivom na vlagu",
volume = "56",
number = "4",
pages = "458-459",
url = "https://hdl.handle.net/21.15107/rcub_farfar_787"
}

Petrović, A., Raić, M., Trajković, S., Ibrić, S., Popović, R., Popadić, D.,& Đurić, Z.. (2006). Effect of film coating and storage conditions on tablets quality with moisture sensitive drug. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 458-459.
https://hdl.handle.net/21.15107/rcub_farfar_787

Petrović A, Raić M, Trajković S, Ibrić S, Popović R, Popadić D, Đurić Z. Effect of film coating and storage conditions on tablets quality with moisture sensitive drug. in Arhiv za farmaciju. 2006;56(4):458-459.
https://hdl.handle.net/21.15107/rcub_farfar_787 .

Petrović, Aleksandra, Raić, M., Trajković, Svetlana, Ibrić, Svetlana, Popović, R., Popadić, Dragica, Đurić, Zorica, "Effect of film coating and storage conditions on tablets quality with moisture sensitive drug" in Arhiv za farmaciju, 56, no. 4 (2006):458-459,
https://hdl.handle.net/21.15107/rcub_farfar_787 .

TY  - CONF
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Ibrić, Svetlana
AU  - Trajković, Svetlana
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/788
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design
T1  - Ispitivanje oslobađanja leka iz matriks tableta na bazi karbomer-a i HPMC-a primenom eksperimentalnog dizajna
VL  - 56
IS  - 4
SP  - 460
EP  - 461
UR  - https://hdl.handle.net/21.15107/rcub_farfar_788
ER  - 

@conference{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Ibrić, Svetlana and Trajković, Svetlana and Popadić, Dragica and Đurić, Zorica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design, Ispitivanje oslobađanja leka iz matriks tableta na bazi karbomer-a i HPMC-a primenom eksperimentalnog dizajna",
volume = "56",
number = "4",
pages = "460-461",
url = "https://hdl.handle.net/21.15107/rcub_farfar_788"
}

Petrović, A., Cvetković, N., Ibrić, S., Trajković, S., Popadić, D.,& Đurić, Z.. (2006). Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 460-461.
https://hdl.handle.net/21.15107/rcub_farfar_788

Petrović A, Cvetković N, Ibrić S, Trajković S, Popadić D, Đurić Z. Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design. in Arhiv za farmaciju. 2006;56(4):460-461.
https://hdl.handle.net/21.15107/rcub_farfar_788 .

Petrović, Aleksandra, Cvetković, Nebojša, Ibrić, Svetlana, Trajković, Svetlana, Popadić, Dragica, Đurić, Zorica, "Evaluation of drug release from matrix tablets containing carbomer and HPMC using experimental design" in Arhiv za farmaciju, 56, no. 4 (2006):460-461,
https://hdl.handle.net/21.15107/rcub_farfar_788 .

TY  - CONF
AU  - Petrović, Aleksandra
AU  - Cvetković, Nebojša
AU  - Trajković, Svetlana
AU  - Ibrić, Svetlana
AU  - Popadić, Dragica
AU  - Đurić, Zorica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/792
PB  - Elsevier Science BV, Amsterdam
C3  - Journal of Controlled Release
T1  - Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC
VL  - 116
IS  - 2
DO  - 10.1016/j.jconrel.2006.09.073
ER  - 

@conference{
author = "Petrović, Aleksandra and Cvetković, Nebojša and Trajković, Svetlana and Ibrić, Svetlana and Popadić, Dragica and Đurić, Zorica",
year = "2006",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Controlled Release",
title = "Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC",
volume = "116",
number = "2",
doi = "10.1016/j.jconrel.2006.09.073"
}

Petrović, A., Cvetković, N., Trajković, S., Ibrić, S., Popadić, D.,& Đurić, Z.. (2006). Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC. in Journal of Controlled Release
Elsevier Science BV, Amsterdam., 116(2).
https://doi.org/10.1016/j.jconrel.2006.09.073

Petrović A, Cvetković N, Trajković S, Ibrić S, Popadić D, Đurić Z. Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC. in Journal of Controlled Release. 2006;116(2).
doi:10.1016/j.jconrel.2006.09.073 .

Petrović, Aleksandra, Cvetković, Nebojša, Trajković, Svetlana, Ibrić, Svetlana, Popadić, Dragica, Đurić, Zorica, "Mixture design evaluation of drug release from matrix tablets containing carbomer and HPMC" in Journal of Controlled Release, 116, no. 2 (2006),
https://doi.org/10.1016/j.jconrel.2006.09.073 . .