TY  - JOUR
AU  - Đokić, Marija
AU  - Kachrimanis, Kyriakos
AU  - Solomun, Ljiljana
AU  - Đuriš, Jelena
AU  - Vasiljević, Dragana
AU  - Ibrić, Svetlana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2215
AB  - The aim of this investigation was to examine the effect of a jet-mill and spray-drying process on the physicochemical and aerodynamic dispersion properties of amiloride HCl particles. Micro-fine particles were prepared by a spiral air jet-mill Hosokawa 50 AS and Mini Spray-Dryer B-191. A 2(3-1) fractional factorial experimental design was implemented to screen three jet-mill process parameters. Possible changes in the physicochemical properties of the material due to spiral jet-milling were examined by the determination of the particle size distribution (PSI)), powder true density, powder flowability, diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) and scanning electron microscopy (SEM). The effect of different jet-milling parameters and the spray-drying process on the aerosol dispersion characteristics was examined with a cascade impactor with a preseparator using the Aerolizer (R) dry powder inhaler device (Novartis, Switzerland). The results show that small changes in the particle size within the 1 to 5 mu m range had an impact on the physicochemical and aerosol dispersion properties of jet-milled and spray-dried particles.
PB  - Elsevier Science BV, Amsterdam
T2  - Powder Technology
T1  - A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl
VL  - 262
SP  - 170
EP  - 176
DO  - 10.1016/j.powtec.2014.04.066
ER  - 

@article{
author = "Đokić, Marija and Kachrimanis, Kyriakos and Solomun, Ljiljana and Đuriš, Jelena and Vasiljević, Dragana and Ibrić, Svetlana",
year = "2014",
abstract = "The aim of this investigation was to examine the effect of a jet-mill and spray-drying process on the physicochemical and aerodynamic dispersion properties of amiloride HCl particles. Micro-fine particles were prepared by a spiral air jet-mill Hosokawa 50 AS and Mini Spray-Dryer B-191. A 2(3-1) fractional factorial experimental design was implemented to screen three jet-mill process parameters. Possible changes in the physicochemical properties of the material due to spiral jet-milling were examined by the determination of the particle size distribution (PSI)), powder true density, powder flowability, diffuse reflectance Fourier transform infrared spectroscopy (DRIFTS) and scanning electron microscopy (SEM). The effect of different jet-milling parameters and the spray-drying process on the aerosol dispersion characteristics was examined with a cascade impactor with a preseparator using the Aerolizer (R) dry powder inhaler device (Novartis, Switzerland). The results show that small changes in the particle size within the 1 to 5 mu m range had an impact on the physicochemical and aerosol dispersion properties of jet-milled and spray-dried particles.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Powder Technology",
title = "A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl",
volume = "262",
pages = "170-176",
doi = "10.1016/j.powtec.2014.04.066"
}

Đokić, M., Kachrimanis, K., Solomun, L., Đuriš, J., Vasiljević, D.,& Ibrić, S.. (2014). A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl. in Powder Technology
Elsevier Science BV, Amsterdam., 262, 170-176.
https://doi.org/10.1016/j.powtec.2014.04.066

Đokić M, Kachrimanis K, Solomun L, Đuriš J, Vasiljević D, Ibrić S. A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl. in Powder Technology. 2014;262:170-176.
doi:10.1016/j.powtec.2014.04.066 .

Đokić, Marija, Kachrimanis, Kyriakos, Solomun, Ljiljana, Đuriš, Jelena, Vasiljević, Dragana, Ibrić, Svetlana, "A study of jet-milling and spray-drying process for the physicochemical and aerodynamic dispersion properties of amiloride HCl" in Powder Technology, 262 (2014):170-176,
https://doi.org/10.1016/j.powtec.2014.04.066 . .

TY  - JOUR
AU  - Đokić, Marija
AU  - Đuriš, Jelena
AU  - Solomun, Ljiljana
AU  - Kachrimanis, Kyriakos
AU  - Đurić, Zorica
AU  - Ibrić, Svetlana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2159
AB  - The purpose of this study was to investigate the influence of spiral jet-milling process on the physicochemical characteristics of alpha polymorphic active pharmaceutical ingredient, using Carbamazepine form III as a model drug, and taking into consideration Quality by Design (QbD) approach to pharmaceutical development. A 2((4-1)) factorial screening design was implemented to identify the spiral jet-milling process variables that significantly affect the particle size distribution of milled samples. Diameter of injector nozzles, diameter of ring nozzles and air pressure were selected for further analysis using a 2((3-1)) factorial experimental design. Particle size distribution of additional samples was determined, while physicochemical properties were examined by differential scanning calorimetry (DSC), hot-stage polarized microscopy (HSPM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and compared to those of un-milled drug. The gathered results shown that applied experimental design approach is capable to predict material behavior and could help in better understanding of material behavior during jet-milling process. Created design space (DS) provides assurance of product quality, expressed as the powder particle sizes lower than 5 mu m, as well as, in initial polymorph form existence after jet-milling through combination and interaction of input variables.
PB  - Inst Chemical Engineers, Rugby
T2  - Chemical Engineering Research & Design
T1  - The influence of spiral jet-milling on the physicochemical properties of carbamazepine form III crystals: Quality by design approach
VL  - 92
IS  - 3
SP  - 500
EP  - 508
DO  - 10.1016/j.cherd.2013.09.011
ER  - 

@article{
author = "Đokić, Marija and Đuriš, Jelena and Solomun, Ljiljana and Kachrimanis, Kyriakos and Đurić, Zorica and Ibrić, Svetlana",
year = "2014",
abstract = "The purpose of this study was to investigate the influence of spiral jet-milling process on the physicochemical characteristics of alpha polymorphic active pharmaceutical ingredient, using Carbamazepine form III as a model drug, and taking into consideration Quality by Design (QbD) approach to pharmaceutical development. A 2((4-1)) factorial screening design was implemented to identify the spiral jet-milling process variables that significantly affect the particle size distribution of milled samples. Diameter of injector nozzles, diameter of ring nozzles and air pressure were selected for further analysis using a 2((3-1)) factorial experimental design. Particle size distribution of additional samples was determined, while physicochemical properties were examined by differential scanning calorimetry (DSC), hot-stage polarized microscopy (HSPM), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and compared to those of un-milled drug. The gathered results shown that applied experimental design approach is capable to predict material behavior and could help in better understanding of material behavior during jet-milling process. Created design space (DS) provides assurance of product quality, expressed as the powder particle sizes lower than 5 mu m, as well as, in initial polymorph form existence after jet-milling through combination and interaction of input variables.",
publisher = "Inst Chemical Engineers, Rugby",
journal = "Chemical Engineering Research & Design",
title = "The influence of spiral jet-milling on the physicochemical properties of carbamazepine form III crystals: Quality by design approach",
volume = "92",
number = "3",
pages = "500-508",
doi = "10.1016/j.cherd.2013.09.011"
}

Đokić, M., Đuriš, J., Solomun, L., Kachrimanis, K., Đurić, Z.,& Ibrić, S.. (2014). The influence of spiral jet-milling on the physicochemical properties of carbamazepine form III crystals: Quality by design approach. in Chemical Engineering Research & Design
Inst Chemical Engineers, Rugby., 92(3), 500-508.
https://doi.org/10.1016/j.cherd.2013.09.011

Đokić M, Đuriš J, Solomun L, Kachrimanis K, Đurić Z, Ibrić S. The influence of spiral jet-milling on the physicochemical properties of carbamazepine form III crystals: Quality by design approach. in Chemical Engineering Research & Design. 2014;92(3):500-508.
doi:10.1016/j.cherd.2013.09.011 .

Đokić, Marija, Đuriš, Jelena, Solomun, Ljiljana, Kachrimanis, Kyriakos, Đurić, Zorica, Ibrić, Svetlana, "The influence of spiral jet-milling on the physicochemical properties of carbamazepine form III crystals: Quality by design approach" in Chemical Engineering Research & Design, 92, no. 3 (2014):500-508,
https://doi.org/10.1016/j.cherd.2013.09.011 . .

TY  - CONF
AU  - Plamenac-Bulat, Zorica
AU  - Đokić, Marija
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1111
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium
VL  - 180
IS  - Supplement
SP  - S144
EP  - S144
DO  - 10.1016/j.toxlet.2008.06.353
ER  - 

@conference{
author = "Plamenac-Bulat, Zorica and Đokić, Marija and Đukić-Ćosić, Danijela and Bulat, Petar and Matović, Vesna",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium",
volume = "180",
number = "Supplement",
pages = "S144-S144",
doi = "10.1016/j.toxlet.2008.06.353"
}

Plamenac-Bulat, Z., Đokić, M., Đukić-Ćosić, D., Bulat, P.,& Matović, V.. (2008). Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 180(Supplement), S144-S144.
https://doi.org/10.1016/j.toxlet.2008.06.353

Plamenac-Bulat Z, Đokić M, Đukić-Ćosić D, Bulat P, Matović V. Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium. in Toxicology Letters. 2008;180(Supplement):S144-S144.
doi:10.1016/j.toxlet.2008.06.353 .

Plamenac-Bulat, Zorica, Đokić, Marija, Đukić-Ćosić, Danijela, Bulat, Petar, Matović, Vesna, "Correlation between cadmium and bioelements (magnesium, zinc and cooper) contents in urine of workers occupationally exposed to cadmium" in Toxicology Letters, 180, no. Supplement (2008):S144-S144,
https://doi.org/10.1016/j.toxlet.2008.06.353 . .