TY  - CONF
AU  - Petrović, Jelena
AU  - Stojanović, Natalija
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4130
AB  - Увод: Самомедикација (СМ) подразумева употребу лекова за лечење једноставних стања, без претходне консултације са лекаром. Од великог значаја је да се студенти биомедицинских наука, будући здравствени радници, понашају одговорно у погледу самомедикације дајући тако пример општој популацији. Циљ рада: Испитати ставове и искуства студената биомедицинских наука у погледу самомедикације и употребе дијететских суплемената (ДС) током пандемије COVID-19. Материјал и методе: Студија пресека је спроведена током периода 15. фебруар - 04. март 2022. године, помоћу упитника у online формату. У истраживању je учествовало 510 студената. Подаци су обрађени методом дескриптивне статистике. Резултати: Као разлог самомедикације 83,33% студената је навело једноставнија стања/болести. Њих 91,96% прибегавало је самомедикацији главобоље. Најфреквентније коришћени лекови (99,02%) били су аналгетици/антипиретици. Поредећи период пре и током пандемије, 63,1% студената је навело да нису чешће прибегавали самомедикацији током пандемије, док је 55,1% студената повећало употребу ДС. Најкоришћенији ДС био је витамин Ц (пре пандемије 69,4%, током пандемије 55,9% студената). Највећи број студената чита упутства за лек који користе у СМ (73,1%), као и са ДС (82,4%). Закључак: Иако је уочена висока преваленца самомедикације, истраживање показује доста елемената одговорне СМ међу студентима биомедицинских наука. Резултати указују да нема промена у обиму СМ пре и током пандемије, али и на чешћу примену ДС током пандемије, углавном у циљу јачања имуног система.
AB  - Introduction: Self-medication (SM) is defined as using medication for treating minor conditions/diseases, without prior consultation with the doctor. It is crucial that biomedical students, as future healthcare professionals, act responsibly regarding self-medication and lead by an example for the general population.
The Aim: Assaying opinions, knowledge, and behaviors of biomedical students regarding self-medication and the use of dietary supplements (DS) during the pandemic of COVID-19.
Material and Methods: Cross-sectional study was conducted from the 15th of February to the 4th of March 2022. Data was gathered by an online survey and refind using descriptive statistics. The sample was 510 biomedical students.
Results: 83.33% of students expressed that falling sick was the main reason for SM. 91.96% used analgetics/antipyretics (99.02%) for treating headaches. 63.1% didn’t practice SM more frequently due to COVID-19, but they did use DS more (55.1%). The most used DS was vitamin C with 69.4% before and 55.9% during the pandemic. Most of the students read the manual for the medication (73.1%) like with the DS as well (82.4%).
Conclusion: Even though the prevalence of self-medication is high, the majority use medication and DS rationally. Research shows there is no difference in the extent of SM before and after the pandemic however the usage of DS has increased due to COVID-19 predominantly for boosting the immune system.
T1  - Самомедикација у популацији студената биомедицинских наука током пандемије COVID-19
T1  - Practice of self-medication among students of biomedical sciences during the pandemic of COVID-19
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4130
ER  - 

@conference{
author = "Petrović, Jelena and Stojanović, Natalija",
year = "2022",
abstract = "Увод: Самомедикација (СМ) подразумева употребу лекова за лечење једноставних стања, без претходне консултације са лекаром. Од великог значаја је да се студенти биомедицинских наука, будући здравствени радници, понашају одговорно у погледу самомедикације дајући тако пример општој популацији. Циљ рада: Испитати ставове и искуства студената биомедицинских наука у погледу самомедикације и употребе дијететских суплемената (ДС) током пандемије COVID-19. Материјал и методе: Студија пресека је спроведена током периода 15. фебруар - 04. март 2022. године, помоћу упитника у online формату. У истраживању je учествовало 510 студената. Подаци су обрађени методом дескриптивне статистике. Резултати: Као разлог самомедикације 83,33% студената је навело једноставнија стања/болести. Њих 91,96% прибегавало је самомедикацији главобоље. Најфреквентније коришћени лекови (99,02%) били су аналгетици/антипиретици. Поредећи период пре и током пандемије, 63,1% студената је навело да нису чешће прибегавали самомедикацији током пандемије, док је 55,1% студената повећало употребу ДС. Најкоришћенији ДС био је витамин Ц (пре пандемије 69,4%, током пандемије 55,9% студената). Највећи број студената чита упутства за лек који користе у СМ (73,1%), као и са ДС (82,4%). Закључак: Иако је уочена висока преваленца самомедикације, истраживање показује доста елемената одговорне СМ међу студентима биомедицинских наука. Резултати указују да нема промена у обиму СМ пре и током пандемије, али и на чешћу примену ДС током пандемије, углавном у циљу јачања имуног система., Introduction: Self-medication (SM) is defined as using medication for treating minor conditions/diseases, without prior consultation with the doctor. It is crucial that biomedical students, as future healthcare professionals, act responsibly regarding self-medication and lead by an example for the general population.
The Aim: Assaying opinions, knowledge, and behaviors of biomedical students regarding self-medication and the use of dietary supplements (DS) during the pandemic of COVID-19.
Material and Methods: Cross-sectional study was conducted from the 15th of February to the 4th of March 2022. Data was gathered by an online survey and refind using descriptive statistics. The sample was 510 biomedical students.
Results: 83.33% of students expressed that falling sick was the main reason for SM. 91.96% used analgetics/antipyretics (99.02%) for treating headaches. 63.1% didn’t practice SM more frequently due to COVID-19, but they did use DS more (55.1%). The most used DS was vitamin C with 69.4% before and 55.9% during the pandemic. Most of the students read the manual for the medication (73.1%) like with the DS as well (82.4%).
Conclusion: Even though the prevalence of self-medication is high, the majority use medication and DS rationally. Research shows there is no difference in the extent of SM before and after the pandemic however the usage of DS has increased due to COVID-19 predominantly for boosting the immune system.",
title = "Самомедикација у популацији студената биомедицинских наука током пандемије COVID-19, Practice of self-medication among students of biomedical sciences during the pandemic of COVID-19",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4130"
}

Petrović, J.,& Stojanović, N.. (2022). Самомедикација у популацији студената биомедицинских наука током пандемије COVID-19. .
https://hdl.handle.net/21.15107/rcub_farfar_4130

Petrović J, Stojanović N. Самомедикација у популацији студената биомедицинских наука током пандемије COVID-19. 2022;.
https://hdl.handle.net/21.15107/rcub_farfar_4130 .

Petrović, Jelena, Stojanović, Natalija, "Самомедикација у популацији студената биомедицинских наука током пандемије COVID-19" (2022),
https://hdl.handle.net/21.15107/rcub_farfar_4130 .

TY  - CONF
AU  - Pejušković, Bojana
AU  - Lero, M.
AU  - Đekić, J.
AU  - Nikolašević, Gorana
AU  - Dobrosavljević, Ana
AU  - Petrović, Jelena
AU  - Pešić, Vesna
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4364
AB  - Depression causes immense burden on health care systems worldwide with two time s higher prevalence in women. However, both male and female patients are treated with antidepressants under same protocols. As it was demonstrated that estrogen has a prodepressant and testosterone an antidepressant affect, it is reasonable to assume that pharmacotherapeutic effect might depend also on sex hormones status. The aim of this pilot study was to explore hormonal status of female and male patients upon hospitalization on occurrence of depressive episode and to correlate it with pharmacotherapy effect after four weeks of therapy. Subjects were 42 patients, 14 males, 14 females in the first (follicular) phase of menstrual cycle and 14 females in the second (luteal) phase of menstrual cycle upon hospitalization. The Hamilton scale was used to determine degree of depressive state upon hospitalization an after 28 days. At both time points, blood was sampled and level of testosterone and estrogen for male and estrogen, progesterone and testosterone for female patients was analysed. Results of the study showed that antidepressant effect calculated as a difference in Hamilton scale was highest in male group of patients and significantly higher than in women in the second phase of the cycle (10.4 vs 8.1). This correlated with increase of testosterone in male patients during four weeks treatment (12.08 vs. 9.46), while there was no significant change in the level of testosterone in both female groups of patients. Furthermore, in female patients in the luteal phase of the cycle, with lowest response to antidepressants, both estrogen and progesterone were significantly reduced during four weeks of treatment. In conclusion, results of our pilot study suggest sex differences in response to antidepressant therapy and level of hormonal status should be evaluated for better personalized pharmacotherapy.
PB  - John Wiley & Sons, Inc
C3  - FEBS Open Bio
T1  - Sex steroid hormones status influence on
antidepressant pharmacotherapy effect in
male and female patients
VL  - 12
IS  - S1
SP  - 325
EP  - 325
DO  - 10.1002/2211-5463.13440
ER  - 

@conference{
author = "Pejušković, Bojana and Lero, M. and Đekić, J. and Nikolašević, Gorana and Dobrosavljević, Ana and Petrović, Jelena and Pešić, Vesna",
year = "2022",
abstract = "Depression causes immense burden on health care systems worldwide with two time s higher prevalence in women. However, both male and female patients are treated with antidepressants under same protocols. As it was demonstrated that estrogen has a prodepressant and testosterone an antidepressant affect, it is reasonable to assume that pharmacotherapeutic effect might depend also on sex hormones status. The aim of this pilot study was to explore hormonal status of female and male patients upon hospitalization on occurrence of depressive episode and to correlate it with pharmacotherapy effect after four weeks of therapy. Subjects were 42 patients, 14 males, 14 females in the first (follicular) phase of menstrual cycle and 14 females in the second (luteal) phase of menstrual cycle upon hospitalization. The Hamilton scale was used to determine degree of depressive state upon hospitalization an after 28 days. At both time points, blood was sampled and level of testosterone and estrogen for male and estrogen, progesterone and testosterone for female patients was analysed. Results of the study showed that antidepressant effect calculated as a difference in Hamilton scale was highest in male group of patients and significantly higher than in women in the second phase of the cycle (10.4 vs 8.1). This correlated with increase of testosterone in male patients during four weeks treatment (12.08 vs. 9.46), while there was no significant change in the level of testosterone in both female groups of patients. Furthermore, in female patients in the luteal phase of the cycle, with lowest response to antidepressants, both estrogen and progesterone were significantly reduced during four weeks of treatment. In conclusion, results of our pilot study suggest sex differences in response to antidepressant therapy and level of hormonal status should be evaluated for better personalized pharmacotherapy.",
publisher = "John Wiley & Sons, Inc",
journal = "FEBS Open Bio",
title = "Sex steroid hormones status influence on
antidepressant pharmacotherapy effect in
male and female patients",
volume = "12",
number = "S1",
pages = "325-325",
doi = "10.1002/2211-5463.13440"
}

Pejušković, B., Lero, M., Đekić, J., Nikolašević, G., Dobrosavljević, A., Petrović, J.,& Pešić, V.. (2022). Sex steroid hormones status influence on
antidepressant pharmacotherapy effect in
male and female patients. in FEBS Open Bio
John Wiley & Sons, Inc., 12(S1), 325-325.
https://doi.org/10.1002/2211-5463.13440

Pejušković B, Lero M, Đekić J, Nikolašević G, Dobrosavljević A, Petrović J, Pešić V. Sex steroid hormones status influence on
antidepressant pharmacotherapy effect in
male and female patients. in FEBS Open Bio. 2022;12(S1):325-325.
doi:10.1002/2211-5463.13440 .

Pejušković, Bojana, Lero, M., Đekić, J., Nikolašević, Gorana, Dobrosavljević, Ana, Petrović, Jelena, Pešić, Vesna, "Sex steroid hormones status influence on
antidepressant pharmacotherapy effect in
male and female patients" in FEBS Open Bio, 12, no. S1 (2022):325-325,
https://doi.org/10.1002/2211-5463.13440 . .

TY  - THES
AU  - Petrović, Jelena
PY  - 2021
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=8481
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:24882/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49345033
UR  - https://nardus.mpn.gov.rs/handle/123456789/18911
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4042
AB  - Depresija pogađa 322 miliona ljudi u svetu i jedan od neurobioloških mehanizama koji doprinosi manifestaciji je hiperaktivnost ose hipotalamus-hipofiza-nadbubreg (HPA). Rizik za nastanak kardiovaskularnih oboljenja je dvostruko povišen kod depresivnih osoba. Poznato je da deficit magnezijuma (Mg) može indukovati hiperaktivnost HPA ose. Cilj istraživanja bio je da se u modelu depresije rezistentne na triciklične antidepresive, indukovane ACTH tretmanom (10 μg/dan, 21 dan) ispitaju bihejvioralni efekti primene Mg (300 mg magnezijuma/L vode za piće, 28 dana) i uticaj na parametre HPA osovine i neurogeneze kod pacova. Drugi cilj bio je da se ispitaju kardioprotektivni efekti Mg i uticaj na proliferaciju kardiomiocita. Treći cilj bio je da se odrede in vitro efekti ACTH u trodimenzionalnom modelu sferoida humanih kardiomiocita. Rezultati istraživanja su pokazali da je u modelu depresije rezistentne na triciklične antidepresive Mg ostvario anksiolitički i antidepresivni efekat kod mužjaka Wistar pacova. Mg je suprimirao hiperaktivnost HPA ose, što se manifestovalo smanjenjem nivoa kortikosterona i IL- 6 u plazmi. Pored toga, Mg je delovao inhibitorno na proliferaciju fibroblasta i endotelnih ćelija, ali i deponovanje endomizijalnog kolagena u srcu, indukovanih ACTH tretmanom. Takođe, ACTH i Mg su delovali stimulatorno na proliferaciju kardiomiocita. U in vitro modelu, visoka koncentracija ACTH nije uticala na apoptozu, ali je indukovala porast ATP u kardiomiocitima. Rezultati ukazuju da antidepresivni efekat Mg nastupa zahvaljujući supresiji hiperaktivnosti HPA ose i stimulaciji neurogeneze. Magnezijum deluje i kardioprotektivno i inhibira razvoj fibroze miokarda, indukovane primenom ACTH. U modelu sferoida, visoka koncentracija ACTH izaziva hipertrofiju kardiomiocita.
AB  - Depression affects 322 million people worldwide and one of the underlying neurobiological mechanisms involves hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. People who suffer from depression show a two-fold increased risk of cardiovascular disease. Studies have shown that magnesium deficiency can provoke HPA axis hyperactivity. The aim of our research was to examine the effects of Mg treatment (300 mg/L, 28 days) on behavioral changes and parameters of HPA axis and neurogenesis in rats, in a model of depressive-like behavior induced by chronic administration of adrenocorticotropic hormone (10 μg/day, 21 days) and resistant to tricyclic antidepressants. Our second aim was to explore cardioprotective effects of Mg, as well as changes in cardiomyocyte proliferation. The third aim was to investigate in vitro effects of ACTH exposure on human cardiomyocytes in a 3D model of spheroids. Results have shown that Mg exerts anxiolytic and antidepressant effects in male Wistar rats, in a model of depressive-like behavior resistant to tricyclic antidepressants. Furthermore, Mg supressed proliferation of fibroblasts and endothelial cells and endomysial collagen deposition evoked by ACTH treatment. ACTH and Mg treatment promoted cardiomyocyte proliferation. In our in vitro model, exposure to high ACTH concentration did not alter level of cardiomyocyte apoptosis, however, an increase in ATP was observed. Mg exerts anxiolytic- and antidepressant-like effects and possible underpinning mechanisms involve attenuated HPA axis hyperactivity and increase in neurogenesis. Moreover, Mg attenuates ACTH-evoked cardiac fibrosis in rats, whereas in vitro exposure to high concentrations of ACTH induces changes that potentially reflect cardiomyocyte hypertrophy.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Uticaj magnezijuma na ponašanje, neuroendokrine i poromene na miokardu uzrokovane hiperaktivnošću osovine hipotalamus-hipofiza-nadbubreg kod pacova
UR  - https://hdl.handle.net/21.15107/rcub_nardus_18911
ER  - 

@phdthesis{
author = "Petrović, Jelena",
year = "2021",
abstract = "Depresija pogađa 322 miliona ljudi u svetu i jedan od neurobioloških mehanizama koji doprinosi manifestaciji je hiperaktivnost ose hipotalamus-hipofiza-nadbubreg (HPA). Rizik za nastanak kardiovaskularnih oboljenja je dvostruko povišen kod depresivnih osoba. Poznato je da deficit magnezijuma (Mg) može indukovati hiperaktivnost HPA ose. Cilj istraživanja bio je da se u modelu depresije rezistentne na triciklične antidepresive, indukovane ACTH tretmanom (10 μg/dan, 21 dan) ispitaju bihejvioralni efekti primene Mg (300 mg magnezijuma/L vode za piće, 28 dana) i uticaj na parametre HPA osovine i neurogeneze kod pacova. Drugi cilj bio je da se ispitaju kardioprotektivni efekti Mg i uticaj na proliferaciju kardiomiocita. Treći cilj bio je da se odrede in vitro efekti ACTH u trodimenzionalnom modelu sferoida humanih kardiomiocita. Rezultati istraživanja su pokazali da je u modelu depresije rezistentne na triciklične antidepresive Mg ostvario anksiolitički i antidepresivni efekat kod mužjaka Wistar pacova. Mg je suprimirao hiperaktivnost HPA ose, što se manifestovalo smanjenjem nivoa kortikosterona i IL- 6 u plazmi. Pored toga, Mg je delovao inhibitorno na proliferaciju fibroblasta i endotelnih ćelija, ali i deponovanje endomizijalnog kolagena u srcu, indukovanih ACTH tretmanom. Takođe, ACTH i Mg su delovali stimulatorno na proliferaciju kardiomiocita. U in vitro modelu, visoka koncentracija ACTH nije uticala na apoptozu, ali je indukovala porast ATP u kardiomiocitima. Rezultati ukazuju da antidepresivni efekat Mg nastupa zahvaljujući supresiji hiperaktivnosti HPA ose i stimulaciji neurogeneze. Magnezijum deluje i kardioprotektivno i inhibira razvoj fibroze miokarda, indukovane primenom ACTH. U modelu sferoida, visoka koncentracija ACTH izaziva hipertrofiju kardiomiocita., Depression affects 322 million people worldwide and one of the underlying neurobiological mechanisms involves hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. People who suffer from depression show a two-fold increased risk of cardiovascular disease. Studies have shown that magnesium deficiency can provoke HPA axis hyperactivity. The aim of our research was to examine the effects of Mg treatment (300 mg/L, 28 days) on behavioral changes and parameters of HPA axis and neurogenesis in rats, in a model of depressive-like behavior induced by chronic administration of adrenocorticotropic hormone (10 μg/day, 21 days) and resistant to tricyclic antidepressants. Our second aim was to explore cardioprotective effects of Mg, as well as changes in cardiomyocyte proliferation. The third aim was to investigate in vitro effects of ACTH exposure on human cardiomyocytes in a 3D model of spheroids. Results have shown that Mg exerts anxiolytic and antidepressant effects in male Wistar rats, in a model of depressive-like behavior resistant to tricyclic antidepressants. Furthermore, Mg supressed proliferation of fibroblasts and endothelial cells and endomysial collagen deposition evoked by ACTH treatment. ACTH and Mg treatment promoted cardiomyocyte proliferation. In our in vitro model, exposure to high ACTH concentration did not alter level of cardiomyocyte apoptosis, however, an increase in ATP was observed. Mg exerts anxiolytic- and antidepressant-like effects and possible underpinning mechanisms involve attenuated HPA axis hyperactivity and increase in neurogenesis. Moreover, Mg attenuates ACTH-evoked cardiac fibrosis in rats, whereas in vitro exposure to high concentrations of ACTH induces changes that potentially reflect cardiomyocyte hypertrophy.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Uticaj magnezijuma na ponašanje, neuroendokrine i poromene na miokardu uzrokovane hiperaktivnošću osovine hipotalamus-hipofiza-nadbubreg kod pacova",
url = "https://hdl.handle.net/21.15107/rcub_nardus_18911"
}

Petrović, J.. (2021). Uticaj magnezijuma na ponašanje, neuroendokrine i poromene na miokardu uzrokovane hiperaktivnošću osovine hipotalamus-hipofiza-nadbubreg kod pacova. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_18911

Petrović J. Uticaj magnezijuma na ponašanje, neuroendokrine i poromene na miokardu uzrokovane hiperaktivnošću osovine hipotalamus-hipofiza-nadbubreg kod pacova. in Универзитет у Београду. 2021;.
https://hdl.handle.net/21.15107/rcub_nardus_18911 .

Petrović, Jelena, "Uticaj magnezijuma na ponašanje, neuroendokrine i poromene na miokardu uzrokovane hiperaktivnošću osovine hipotalamus-hipofiza-nadbubreg kod pacova" in Универзитет у Београду (2021),
https://hdl.handle.net/21.15107/rcub_nardus_18911 .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Pešić, Vesna
AU  - Lauschke, Volker M.
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3501
AB  - CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved in the metabolism of around 30% of allmedications. Importantly, the corresponding genes are highly polymorphic and these genetic differences contribute tointerindividual and interethnic differences in drug pharmacokinetics, response, and toxicity. In this study we systematicallyanalyzed the frequency distribution of clinically relevantCYP2C19andCYP2D6alleles across Europe based on data from82,791 healthy individuals extracted from 79 original publications and, for thefirst time, provide allele confidence intervalsfor the general population. We found that frequencies ofCYP2D6gene duplications showed a clear South-East to North-West gradient ranging from <1% in Sweden and Denmark to 6% in Greece and Turkey. In contrast, an inverse distributionwas observed for the loss-of-function allelesCYP2D6*4andCYP2D6*5. Similarly, frequencies of the inactiveCYP2C19*2allele were graded from North-West to South-East Europe. In important contrast to previous work we found that theincreased activity alleleCYP2C19*17was most prevalent in Central Europe (25–33%) with lower prevalence inMediterranean-South Europeans (11–24%). In summary, we provide a detailed European map of commonCYP2C19andCYP2D6variants andfind that frequencies of the most clinically relevant alleles are geographically graded reflective ofEurope’s migratory history. Thesefindings emphasize the importance of generating pharmacogenomic data sets with highspatial resolution to improve precision public health across Europe.
PB  - Springer Nature
T2  - European Journal of Human Genetics
T1  - Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe
VL  - 28
IS  - 1
SP  - 88
EP  - 94
DO  - 10.1038/s41431-019-0480-8
ER  - 

@article{
author = "Petrović, Jelena and Pešić, Vesna and Lauschke, Volker M.",
year = "2020",
abstract = "CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved in the metabolism of around 30% of allmedications. Importantly, the corresponding genes are highly polymorphic and these genetic differences contribute tointerindividual and interethnic differences in drug pharmacokinetics, response, and toxicity. In this study we systematicallyanalyzed the frequency distribution of clinically relevantCYP2C19andCYP2D6alleles across Europe based on data from82,791 healthy individuals extracted from 79 original publications and, for thefirst time, provide allele confidence intervalsfor the general population. We found that frequencies ofCYP2D6gene duplications showed a clear South-East to North-West gradient ranging from <1% in Sweden and Denmark to 6% in Greece and Turkey. In contrast, an inverse distributionwas observed for the loss-of-function allelesCYP2D6*4andCYP2D6*5. Similarly, frequencies of the inactiveCYP2C19*2allele were graded from North-West to South-East Europe. In important contrast to previous work we found that theincreased activity alleleCYP2C19*17was most prevalent in Central Europe (25–33%) with lower prevalence inMediterranean-South Europeans (11–24%). In summary, we provide a detailed European map of commonCYP2C19andCYP2D6variants andfind that frequencies of the most clinically relevant alleles are geographically graded reflective ofEurope’s migratory history. Thesefindings emphasize the importance of generating pharmacogenomic data sets with highspatial resolution to improve precision public health across Europe.",
publisher = "Springer Nature",
journal = "European Journal of Human Genetics",
title = "Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe",
volume = "28",
number = "1",
pages = "88-94",
doi = "10.1038/s41431-019-0480-8"
}

Petrović, J., Pešić, V.,& Lauschke, V. M.. (2020). Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe. in European Journal of Human Genetics
Springer Nature., 28(1), 88-94.
https://doi.org/10.1038/s41431-019-0480-8

Petrović J, Pešić V, Lauschke VM. Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe. in European Journal of Human Genetics. 2020;28(1):88-94.
doi:10.1038/s41431-019-0480-8 .

Petrović, Jelena, Pešić, Vesna, Lauschke, Volker M., "Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe" in European Journal of Human Genetics, 28, no. 1 (2020):88-94,
https://doi.org/10.1038/s41431-019-0480-8 . .

TY  - JOUR
AU  - Durić, Vedrana
AU  - Batinić, Bojan
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Bulat, Zorica
AU  - Pešić, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3172
AB  - Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.
PB  - John Libbey Eurotext Ltd, Montrouge
T2  - Magnesium Research
T1  - A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats
VL  - 31
IS  - 1
SP  - 24
EP  - 32
DO  - 10.1684/mrh.2018.0435
ER  - 

@article{
author = "Durić, Vedrana and Batinić, Bojan and Petrović, Jelena and Stanić, Dušanka and Bulat, Zorica and Pešić, Vesna",
year = "2018",
abstract = "Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.",
publisher = "John Libbey Eurotext Ltd, Montrouge",
journal = "Magnesium Research",
title = "A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats",
volume = "31",
number = "1",
pages = "24-32",
doi = "10.1684/mrh.2018.0435"
}

Durić, V., Batinić, B., Petrović, J., Stanić, D., Bulat, Z.,& Pešić, V.. (2018). A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. in Magnesium Research
John Libbey Eurotext Ltd, Montrouge., 31(1), 24-32.
https://doi.org/10.1684/mrh.2018.0435

Durić V, Batinić B, Petrović J, Stanić D, Bulat Z, Pešić V. A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. in Magnesium Research. 2018;31(1):24-32.
doi:10.1684/mrh.2018.0435 .

Durić, Vedrana, Batinić, Bojan, Petrović, Jelena, Stanić, Dušanka, Bulat, Zorica, Pešić, Vesna, "A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats" in Magnesium Research, 31, no. 1 (2018):24-32,
https://doi.org/10.1684/mrh.2018.0435 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Bulat, Zorica
AU  - Puskas, Nela
AU  - Labudović-Borović, Milica
AU  - Batinić, Bojan
AU  - Mirković, Duško
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3042
AB  - Magnesium (Mg), is not only a modulator of the glutamatergic NMDA receptors' affinity, it also prevents HPA axis hyperactivity, thus possibly being implicated in neurobiological features of mood disorders. Further uncovering of molecular mechanisms underlying magnesium's proposed effects is needed due to the recent shift in research of treatment resistant depression (TRD) towards glutamatergic pathways. Here, we applied Mg via drinking water for 28 days (50 mg/kg/day), in ACTH-treated rats, an established animal model of depression resistant to tricyclic antidepressants. Using this model in male rats we measured (1) changes in hippocampal neurogenesis and behavioral alterations, (2) adrenal hormones response to acute stress challenge and (3) levels of biometals involved in regulation of monoamines turnover in rat prefrontal cortex. Our results support beneficial behavioral impact of Mg in TRD model together with increased hippocampal neurogenesis and BDNF expression. Furthermore, Mg prevented ACTH-induced disruption in HPA axis function, by normalizing the levels of plasma ACTH, corticosterone and interleukin-6, and by increasing the peripheral release of adrenaline, noradrenaline and serotonin after the acute stress challenge. Finally, the influence on copper/zinc ratio suggested probable magnesium's involvement in monoamine turnover in PFC. Our findings provide further insights into the possible pathways implicated in the behavioral modulation effects of Mg, as well as its central and peripheral effects in ACTH-induced TRD model. Thus, further investigation of molecular signaling related to the glutamatergic transmission and role of Mg, could reveal prospects to novel treatment strategies that could be of particular importance for patients suffering from TRD.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Hormones and Behavior
T1  - Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration
VL  - 105
SP  - 1
EP  - 10
DO  - 10.1016/j.yhbeh.2018.07.003
ER  - 

@article{
author = "Petrović, Jelena and Stanić, Dušanka and Bulat, Zorica and Puskas, Nela and Labudović-Borović, Milica and Batinić, Bojan and Mirković, Duško and Ignjatović, Svetlana and Pešić, Vesna",
year = "2018",
abstract = "Magnesium (Mg), is not only a modulator of the glutamatergic NMDA receptors' affinity, it also prevents HPA axis hyperactivity, thus possibly being implicated in neurobiological features of mood disorders. Further uncovering of molecular mechanisms underlying magnesium's proposed effects is needed due to the recent shift in research of treatment resistant depression (TRD) towards glutamatergic pathways. Here, we applied Mg via drinking water for 28 days (50 mg/kg/day), in ACTH-treated rats, an established animal model of depression resistant to tricyclic antidepressants. Using this model in male rats we measured (1) changes in hippocampal neurogenesis and behavioral alterations, (2) adrenal hormones response to acute stress challenge and (3) levels of biometals involved in regulation of monoamines turnover in rat prefrontal cortex. Our results support beneficial behavioral impact of Mg in TRD model together with increased hippocampal neurogenesis and BDNF expression. Furthermore, Mg prevented ACTH-induced disruption in HPA axis function, by normalizing the levels of plasma ACTH, corticosterone and interleukin-6, and by increasing the peripheral release of adrenaline, noradrenaline and serotonin after the acute stress challenge. Finally, the influence on copper/zinc ratio suggested probable magnesium's involvement in monoamine turnover in PFC. Our findings provide further insights into the possible pathways implicated in the behavioral modulation effects of Mg, as well as its central and peripheral effects in ACTH-induced TRD model. Thus, further investigation of molecular signaling related to the glutamatergic transmission and role of Mg, could reveal prospects to novel treatment strategies that could be of particular importance for patients suffering from TRD.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Hormones and Behavior",
title = "Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration",
volume = "105",
pages = "1-10",
doi = "10.1016/j.yhbeh.2018.07.003"
}

Petrović, J., Stanić, D., Bulat, Z., Puskas, N., Labudović-Borović, M., Batinić, B., Mirković, D., Ignjatović, S.,& Pešić, V.. (2018). Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration. in Hormones and Behavior
Academic Press Inc Elsevier Science, San Diego., 105, 1-10.
https://doi.org/10.1016/j.yhbeh.2018.07.003

Petrović J, Stanić D, Bulat Z, Puskas N, Labudović-Borović M, Batinić B, Mirković D, Ignjatović S, Pešić V. Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration. in Hormones and Behavior. 2018;105:1-10.
doi:10.1016/j.yhbeh.2018.07.003 .

Petrović, Jelena, Stanić, Dušanka, Bulat, Zorica, Puskas, Nela, Labudović-Borović, Milica, Batinić, Bojan, Mirković, Duško, Ignjatović, Svetlana, Pešić, Vesna, "Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration" in Hormones and Behavior, 105 (2018):1-10,
https://doi.org/10.1016/j.yhbeh.2018.07.003 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Labudović-Borović, Milica
AU  - Puškaš, Nela
AU  - Stanić, Dušanka
AU  - Batinić, Bojan
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2894
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats
VL  - 27
IS  - Supplement 4
SP  - S765
EP  - S766
DO  - 10.1016/S0924-977X(17)31398-6
ER  - 

@conference{
author = "Petrović, Jelena and Labudović-Borović, Milica and Puškaš, Nela and Stanić, Dušanka and Batinić, Bojan and Plećaš-Solarović, Bosiljka and Pešić, Vesna",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats",
volume = "27",
number = "Supplement 4",
pages = "S765-S766",
doi = "10.1016/S0924-977X(17)31398-6"
}

Petrović, J., Labudović-Borović, M., Puškaš, N., Stanić, D., Batinić, B., Plećaš-Solarović, B.,& Pešić, V.. (2017). Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 27(Supplement 4), S765-S766.
https://doi.org/10.1016/S0924-977X(17)31398-6

Petrović J, Labudović-Borović M, Puškaš N, Stanić D, Batinić B, Plećaš-Solarović B, Pešić V. Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats. in European Neuropsychopharmacology. 2017;27(Supplement 4):S765-S766.
doi:10.1016/S0924-977X(17)31398-6 .

Petrović, Jelena, Labudović-Borović, Milica, Puškaš, Nela, Stanić, Dušanka, Batinić, Bojan, Plećaš-Solarović, Bosiljka, Pešić, Vesna, "Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats" in European Neuropsychopharmacology, 27, no. Supplement 4 (2017):S765-S766,
https://doi.org/10.1016/S0924-977X(17)31398-6 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Puškaš, Nela
AU  - Oved, K.
AU  - Gurwitz, D.
AU  - Mirković, Duško
AU  - Plećaš, Bosiljka
AU  - Pešić, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2870
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats
VL  - 27
IS  - Supplement 1
SP  - S34
EP  - S35
DO  - 10.1016/S0924-977X(17)30104-9
ER  - 

@conference{
author = "Petrović, Jelena and Stanić, Dušanka and Puškaš, Nela and Oved, K. and Gurwitz, D. and Mirković, Duško and Plećaš, Bosiljka and Pešić, Vesna",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats",
volume = "27",
number = "Supplement 1",
pages = "S34-S35",
doi = "10.1016/S0924-977X(17)30104-9"
}

Petrović, J., Stanić, D., Puškaš, N., Oved, K., Gurwitz, D., Mirković, D., Plećaš, B.,& Pešić, V.. (2017). Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 27(Supplement 1), S34-S35.
https://doi.org/10.1016/S0924-977X(17)30104-9

Petrović J, Stanić D, Puškaš N, Oved K, Gurwitz D, Mirković D, Plećaš B, Pešić V. Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats. in European Neuropsychopharmacology. 2017;27(Supplement 1):S34-S35.
doi:10.1016/S0924-977X(17)30104-9 .

Petrović, Jelena, Stanić, Dušanka, Puškaš, Nela, Oved, K., Gurwitz, D., Mirković, Duško, Plećaš, Bosiljka, Pešić, Vesna, "Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats" in European Neuropsychopharmacology, 27, no. Supplement 1 (2017):S34-S35,
https://doi.org/10.1016/S0924-977X(17)30104-9 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Dmitrašinović, Gordana
AU  - Plećaš-Solarović, Bosiljka
AU  - Ignjatović, Svetlana
AU  - Batinić, Bojan
AU  - Popović, Dejana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2557
AB  - Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man
DO  - 10.1155/2016/2019643
ER  - 

@article{
author = "Petrović, Jelena and Stanić, Dušanka and Dmitrašinović, Gordana and Plećaš-Solarović, Bosiljka and Ignjatović, Svetlana and Batinić, Bojan and Popović, Dejana and Pešić, Vesna",
year = "2016",
abstract = "Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man",
doi = "10.1155/2016/2019643"
}

Petrović, J., Stanić, D., Dmitrašinović, G., Plećaš-Solarović, B., Ignjatović, S., Batinić, B., Popović, D.,& Pešić, V.. (2016). Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London..
https://doi.org/10.1155/2016/2019643

Petrović J, Stanić D, Dmitrašinović G, Plećaš-Solarović B, Ignjatović S, Batinić B, Popović D, Pešić V. Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. in Oxidative Medicine and Cellular Longevity. 2016;.
doi:10.1155/2016/2019643 .

Petrović, Jelena, Stanić, Dušanka, Dmitrašinović, Gordana, Plećaš-Solarović, Bosiljka, Ignjatović, Svetlana, Batinić, Bojan, Popović, Dejana, Pešić, Vesna, "Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man" in Oxidative Medicine and Cellular Longevity (2016),
https://doi.org/10.1155/2016/2019643 . .

TY  - JOUR
AU  - Stanić, Dušanka
AU  - Plećaš-Solarović, Bosiljka
AU  - Petrović, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Sopić, Miron
AU  - Kotur-Stevuljević, Jelena
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2704
AB  - Contemporary lifestyle is commonly associated with chronic stress, an environmental factor contributing to development of various psychological and somatic disorders. Increased levels of glucocorticoids, observed in the chronic stress, induce the production of reactive oxygen species leading to genotoxicity. The aim of this study was to investigate whether chronic administration of oxytocin (OXY) 10 IU/400 mu L/day, s.c., for 14 days, a hormone presumed to exert antioxidant effect, may prevent DNA damage in the comet assay of peripheral blood lymphocytes of Wistar rats treated chronically with corticosterone (CORT) 100 mg/L ad libitum, per os, for 21 days, as well as, to influence some plasma oxidative stress parameters, i.e. levels of total lipid hydroperoxide (LOOH), and malondialdehyde (MDA), and the activity of antioxidative enzyme superoxide dismutase (SOD). Even though there was no reduction in overall number of damaged cells after oxytocin treatment only, the marked increase in total comet score (TCS) after incubation with H2O2 in CORT group compared to controls, was absent in the CORT + OXY experimental group. Furthermore, significant decrease of highly damaged cells compared to corticosterone group was noted. Chronic oxytocin administration thus protected lymphocytes from high intensity damage that leads to cellular death. In addition, treatment with OXY along with CORT, significantly decreased concentration of LOOH in plasma, and increased SOD compared to CORT treatment only. This finding corresponds well with current reports on beneficial effects of OXY in conditions of HPA axis hyperactivity, and supports the hypothesis of OXY-mediated antioxidant action.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment
VL  - 256
SP  - 134
EP  - 141
DO  - 10.1016/j.cbi.2016.07.006
ER  - 

@article{
author = "Stanić, Dušanka and Plećaš-Solarović, Bosiljka and Petrović, Jelena and Bogavac-Stanojević, Nataša and Sopić, Miron and Kotur-Stevuljević, Jelena and Ignjatović, Svetlana and Pešić, Vesna",
year = "2016",
abstract = "Contemporary lifestyle is commonly associated with chronic stress, an environmental factor contributing to development of various psychological and somatic disorders. Increased levels of glucocorticoids, observed in the chronic stress, induce the production of reactive oxygen species leading to genotoxicity. The aim of this study was to investigate whether chronic administration of oxytocin (OXY) 10 IU/400 mu L/day, s.c., for 14 days, a hormone presumed to exert antioxidant effect, may prevent DNA damage in the comet assay of peripheral blood lymphocytes of Wistar rats treated chronically with corticosterone (CORT) 100 mg/L ad libitum, per os, for 21 days, as well as, to influence some plasma oxidative stress parameters, i.e. levels of total lipid hydroperoxide (LOOH), and malondialdehyde (MDA), and the activity of antioxidative enzyme superoxide dismutase (SOD). Even though there was no reduction in overall number of damaged cells after oxytocin treatment only, the marked increase in total comet score (TCS) after incubation with H2O2 in CORT group compared to controls, was absent in the CORT + OXY experimental group. Furthermore, significant decrease of highly damaged cells compared to corticosterone group was noted. Chronic oxytocin administration thus protected lymphocytes from high intensity damage that leads to cellular death. In addition, treatment with OXY along with CORT, significantly decreased concentration of LOOH in plasma, and increased SOD compared to CORT treatment only. This finding corresponds well with current reports on beneficial effects of OXY in conditions of HPA axis hyperactivity, and supports the hypothesis of OXY-mediated antioxidant action.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment",
volume = "256",
pages = "134-141",
doi = "10.1016/j.cbi.2016.07.006"
}

Stanić, D., Plećaš-Solarović, B., Petrović, J., Bogavac-Stanojević, N., Sopić, M., Kotur-Stevuljević, J., Ignjatović, S.,& Pešić, V.. (2016). Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 256, 134-141.
https://doi.org/10.1016/j.cbi.2016.07.006

Stanić D, Plećaš-Solarović B, Petrović J, Bogavac-Stanojević N, Sopić M, Kotur-Stevuljević J, Ignjatović S, Pešić V. Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment. in Chemico-Biological Interactions. 2016;256:134-141.
doi:10.1016/j.cbi.2016.07.006 .

Stanić, Dušanka, Plećaš-Solarović, Bosiljka, Petrović, Jelena, Bogavac-Stanojević, Nataša, Sopić, Miron, Kotur-Stevuljević, Jelena, Ignjatović, Svetlana, Pešić, Vesna, "Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment" in Chemico-Biological Interactions, 256 (2016):134-141,
https://doi.org/10.1016/j.cbi.2016.07.006 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Mirković, Duško
AU  - Batinić, Bojan
AU  - Plećaš, Bosiljka
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2687
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone
VL  - 26
IS  - Supplement 2
SP  - S207
EP  - S207
DO  - 10.1016/S0924-977X(16)31053-7
ER  - 

@conference{
author = "Petrović, Jelena and Stanić, Dušanka and Mirković, Duško and Batinić, Bojan and Plećaš, Bosiljka and Ignjatović, Svetlana and Pešić, Vesna",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone",
volume = "26",
number = "Supplement 2",
pages = "S207-S207",
doi = "10.1016/S0924-977X(16)31053-7"
}

Petrović, J., Stanić, D., Mirković, D., Batinić, B., Plećaš, B., Ignjatović, S.,& Pešić, V.. (2016). Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S207-S207.
https://doi.org/10.1016/S0924-977X(16)31053-7

Petrović J, Stanić D, Mirković D, Batinić B, Plećaš B, Ignjatović S, Pešić V. Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone. in European Neuropsychopharmacology. 2016;26(Supplement 2):S207-S207.
doi:10.1016/S0924-977X(16)31053-7 .

Petrović, Jelena, Stanić, Dušanka, Mirković, Duško, Batinić, Bojan, Plećaš, Bosiljka, Ignjatović, Svetlana, Pešić, Vesna, "Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S207-S207,
https://doi.org/10.1016/S0924-977X(16)31053-7 . .

TY  - CONF
AU  - Stanić, Dušanka
AU  - Petrović, Jelena
AU  - Mirković, Duško
AU  - Đorđević, Tea
AU  - Durić, V.
AU  - Jovanović, P.
AU  - Dronjak, Slađana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2686
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone
VL  - 26
IS  - Supplement 2
SP  - S204
EP  - S204
DO  - 10.1016/S0924-977X(16)31048-3
ER  - 

@conference{
author = "Stanić, Dušanka and Petrović, Jelena and Mirković, Duško and Đorđević, Tea and Durić, V. and Jovanović, P. and Dronjak, Slađana and Pešić, Vesna",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone",
volume = "26",
number = "Supplement 2",
pages = "S204-S204",
doi = "10.1016/S0924-977X(16)31048-3"
}

Stanić, D., Petrović, J., Mirković, D., Đorđević, T., Durić, V., Jovanović, P., Dronjak, S.,& Pešić, V.. (2016). Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S204-S204.
https://doi.org/10.1016/S0924-977X(16)31048-3

Stanić D, Petrović J, Mirković D, Đorđević T, Durić V, Jovanović P, Dronjak S, Pešić V. Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone. in European Neuropsychopharmacology. 2016;26(Supplement 2):S204-S204.
doi:10.1016/S0924-977X(16)31048-3 .

Stanić, Dušanka, Petrović, Jelena, Mirković, Duško, Đorđević, Tea, Durić, V., Jovanović, P., Dronjak, Slađana, Pešić, Vesna, "Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S204-S204,
https://doi.org/10.1016/S0924-977X(16)31048-3 . .

TY  - CONF
AU  - Pešić, Vesna
AU  - Stanić, Dušanka
AU  - Petrović, Jelena
AU  - Puskas, Nela
AU  - Plećaš, Bosiljka
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2656
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment
VL  - 26
IS  - Supplement 2
SP  - S289
EP  - S289
DO  - 10.1016/S0924-977X(16)31184-1
ER  - 

@conference{
author = "Pešić, Vesna and Stanić, Dušanka and Petrović, Jelena and Puskas, Nela and Plećaš, Bosiljka and Ignjatović, Svetlana",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment",
volume = "26",
number = "Supplement 2",
pages = "S289-S289",
doi = "10.1016/S0924-977X(16)31184-1"
}

Pešić, V., Stanić, D., Petrović, J., Puskas, N., Plećaš, B.,& Ignjatović, S.. (2016). Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S289-S289.
https://doi.org/10.1016/S0924-977X(16)31184-1

Pešić V, Stanić D, Petrović J, Puskas N, Plećaš B, Ignjatović S. Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment. in European Neuropsychopharmacology. 2016;26(Supplement 2):S289-S289.
doi:10.1016/S0924-977X(16)31184-1 .

Pešić, Vesna, Stanić, Dušanka, Petrović, Jelena, Puskas, Nela, Plećaš, Bosiljka, Ignjatović, Svetlana, "Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S289-S289,
https://doi.org/10.1016/S0924-977X(16)31184-1 . .

TY  - JOUR
AU  - Pešić, Vesna
AU  - Petrović, Jelena
AU  - Jukić, Marin
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2625
AB  - The emergence of rapid-acting antidepressants such as ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine antidepressant effect and to enable the clinical application of rapid-acting antidepressants. Here, we provide an overview of studies addressing the antidepressant effects of ketamine in depressed patients and animal models of depression and we compare the reduction of depressive symptoms in humans with the reduction in immobility time in the forced swim test in rodents after acute ketamine treatment. We also discuss different theories and potential biochemical pathways involved in the rapid antidepressant response to ketamine including the modulation of glutamatergic neurotransmission and intracellular hub-kinase activation. Finally, we summarize recent brain-region specific studies and we suggest that the activation of the ventral hippocampusmedial prefrontal cortexdorsal raphae nuclei (vHC-mPFC-DRN) neuronal pathway may mediate the antidepressant effect of ketamine. Although substantial progress has been made, further brain-region specific animal studies and longitudinal clinical trials are necessary for the understanding and successful application of novel rapid-acting antidepressants. Drug Dev Res 77 : 414-422, 2016.
PB  - Wiley, Hoboken
T2  - Drug Development Research
T1  - Molecular Mechanism and Clinical Relevance of Ketamine as Rapid-Acting Antidepressant
VL  - 77
IS  - 7
SP  - 414
EP  - 422
DO  - 10.1002/ddr.21335
ER  - 

@article{
author = "Pešić, Vesna and Petrović, Jelena and Jukić, Marin",
year = "2016",
abstract = "The emergence of rapid-acting antidepressants such as ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine antidepressant effect and to enable the clinical application of rapid-acting antidepressants. Here, we provide an overview of studies addressing the antidepressant effects of ketamine in depressed patients and animal models of depression and we compare the reduction of depressive symptoms in humans with the reduction in immobility time in the forced swim test in rodents after acute ketamine treatment. We also discuss different theories and potential biochemical pathways involved in the rapid antidepressant response to ketamine including the modulation of glutamatergic neurotransmission and intracellular hub-kinase activation. Finally, we summarize recent brain-region specific studies and we suggest that the activation of the ventral hippocampusmedial prefrontal cortexdorsal raphae nuclei (vHC-mPFC-DRN) neuronal pathway may mediate the antidepressant effect of ketamine. Although substantial progress has been made, further brain-region specific animal studies and longitudinal clinical trials are necessary for the understanding and successful application of novel rapid-acting antidepressants. Drug Dev Res 77 : 414-422, 2016.",
publisher = "Wiley, Hoboken",
journal = "Drug Development Research",
title = "Molecular Mechanism and Clinical Relevance of Ketamine as Rapid-Acting Antidepressant",
volume = "77",
number = "7",
pages = "414-422",
doi = "10.1002/ddr.21335"
}

Pešić, V., Petrović, J.,& Jukić, M.. (2016). Molecular Mechanism and Clinical Relevance of Ketamine as Rapid-Acting Antidepressant. in Drug Development Research
Wiley, Hoboken., 77(7), 414-422.
https://doi.org/10.1002/ddr.21335

Pešić V, Petrović J, Jukić M. Molecular Mechanism and Clinical Relevance of Ketamine as Rapid-Acting Antidepressant. in Drug Development Research. 2016;77(7):414-422.
doi:10.1002/ddr.21335 .

Pešić, Vesna, Petrović, Jelena, Jukić, Marin, "Molecular Mechanism and Clinical Relevance of Ketamine as Rapid-Acting Antidepressant" in Drug Development Research, 77, no. 7 (2016):414-422,
https://doi.org/10.1002/ddr.21335 . .

TY  - CONF
AU  - Petrović, Jelena
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2306
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Chronic magnesium administration ameliorates depressive- and anxiety-like behaviour in ACTH-treated rats
VL  - 25
IS  - Supplement 2
SP  - S294
EP  - S295
DO  - 10.1016/S0924-977X(15)30353-9
ER  - 

@conference{
author = "Petrović, Jelena",
year = "2015",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Chronic magnesium administration ameliorates depressive- and anxiety-like behaviour in ACTH-treated rats",
volume = "25",
number = "Supplement 2",
pages = "S294-S295",
doi = "10.1016/S0924-977X(15)30353-9"
}

Petrović, J.. (2015). Chronic magnesium administration ameliorates depressive- and anxiety-like behaviour in ACTH-treated rats. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 25(Supplement 2), S294-S295.
https://doi.org/10.1016/S0924-977X(15)30353-9

Petrović J. Chronic magnesium administration ameliorates depressive- and anxiety-like behaviour in ACTH-treated rats. in European Neuropsychopharmacology. 2015;25(Supplement 2):S294-S295.
doi:10.1016/S0924-977X(15)30353-9 .

Petrović, Jelena, "Chronic magnesium administration ameliorates depressive- and anxiety-like behaviour in ACTH-treated rats" in European Neuropsychopharmacology, 25, no. Supplement 2 (2015):S294-S295,
https://doi.org/10.1016/S0924-977X(15)30353-9 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Pešić, Vesna
AU  - Popović, Dejana
AU  - Plećaš, Bosiljka
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2271
AB  - Magnesium has a fundamental role in human body and it is necessary for many processes such as: transmembrane ion flux, neuronal activity, neurotransmitter release, regulation of adenylate cyclase and hormone receptor binding. In the central nervous system magnesium blocks the activity of NMDA receptors and magnesium-deficiency leads to NMDA receptors overactivity, possibly causing neuronal injury and neurological dysfunction, which consequently may manifest as major depression. Numerous pre-clinical and clinical studies confirmed that magnesium influences several systems associated with development of depression. On the other hand, standard antidepressants are ineffective in 40% of cases, and have some unpleasant side-effects. Even though the first positive effect of magnesium in patients with agitated depression was reported in 1921, unfortunately, only small number of studies that favor magnesium's effectiveness in treating depression was published in past decades, including one randomized clinical trial in which magnesium was as effective as imipramine in depressed elderly patients that suffered from diabetes. Even though much more clinical research is needed to extend this important line of research and to confirm its efficacy, due to its safety magnesium preparations could be considered as a potential addition for treatment resistant depression cases.
AB  - Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Role of magnesium in depression?
T1  - Uloga magnezijuma u depresiji?
VL  - 64
IS  - 4
SP  - 322
EP  - 334
DO  - 10.5937/arhfarm1404322P
ER  - 

@article{
author = "Petrović, Jelena and Pešić, Vesna and Popović, Dejana and Plećaš, Bosiljka",
year = "2014",
abstract = "Magnesium has a fundamental role in human body and it is necessary for many processes such as: transmembrane ion flux, neuronal activity, neurotransmitter release, regulation of adenylate cyclase and hormone receptor binding. In the central nervous system magnesium blocks the activity of NMDA receptors and magnesium-deficiency leads to NMDA receptors overactivity, possibly causing neuronal injury and neurological dysfunction, which consequently may manifest as major depression. Numerous pre-clinical and clinical studies confirmed that magnesium influences several systems associated with development of depression. On the other hand, standard antidepressants are ineffective in 40% of cases, and have some unpleasant side-effects. Even though the first positive effect of magnesium in patients with agitated depression was reported in 1921, unfortunately, only small number of studies that favor magnesium's effectiveness in treating depression was published in past decades, including one randomized clinical trial in which magnesium was as effective as imipramine in depressed elderly patients that suffered from diabetes. Even though much more clinical research is needed to extend this important line of research and to confirm its efficacy, due to its safety magnesium preparations could be considered as a potential addition for treatment resistant depression cases., Magnezijum ima značajnu fiziološku ulogu u humanom organizmu i neophodan je za mnoge procese, uključujući: transmembransko kretanje jona, aktivnost neurona, oslobađanje neurotransmitera, regulaciju adenilat ciklaze i vezivanje pojedinih hormona za receptore. U centralnom nervnom sistemu magnezijum blokira aktivnost NMDA receptora, a deficit magnezijuma dovodi do prekomerne aktivacije NMDA receptora, što za posledicu može imati oštećenja neurona i neurološke disfunkcije i u krajnjoj liniji, može se manifestovati razvojem velike depresije. Brojna pretklinička i klinička ispitivanja potvrđuju da magnezijum utiče na nekoliko sistema uključenih u razvoj depresije. Sa druge strane, oko 40% pacijenata pokazuje rezistenciju na tretman standardnim antidepresivima, kojima se pripisuju i brojni neprijatni neželjeni efekti. Iako je prvi pozitivan učinak magnezijuma kod pacijenata koji pate od agitirane depresije prikazan još 1921, nažalost, samo mali broj studija koje govore u prilog efikasnosti magnezijuma u tretmanu depresije je publikovan tokom proteklih decenija, uključujući jedno randomizovano kliničko ispitivanje koje je pokazalo podjednaku efikasnost magnezijuma i imipramina kod starijih depresivnih pacijenata koji boluju od dijabetesa. Iako je neophodno sprovesti veći broj kliničkih ispitivanja i proširiti ovo polje istraživanja u cilju potvrđivanja njegove efikasnosti, usled svoje bezbednosti, magnezijum bi se potencijalno mogao uvesti kao dodatni tretman u lečenju depresije rezistentne na terapiju.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Role of magnesium in depression?, Uloga magnezijuma u depresiji?",
volume = "64",
number = "4",
pages = "322-334",
doi = "10.5937/arhfarm1404322P"
}

Petrović, J., Pešić, V., Popović, D.,& Plećaš, B.. (2014). Role of magnesium in depression?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 64(4), 322-334.
https://doi.org/10.5937/arhfarm1404322P

Petrović J, Pešić V, Popović D, Plećaš B. Role of magnesium in depression?. in Arhiv za farmaciju. 2014;64(4):322-334.
doi:10.5937/arhfarm1404322P .

Petrović, Jelena, Pešić, Vesna, Popović, Dejana, Plećaš, Bosiljka, "Role of magnesium in depression?" in Arhiv za farmaciju, 64, no. 4 (2014):322-334,
https://doi.org/10.5937/arhfarm1404322P . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Ibrić, Svetlana
AU  - Betz, Gabriele
AU  - Đurić, Zorica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1705
AB  - The main objective of the study was to develop artificial intelligence methods for optimization of drug release from matrix tablets regardless of the matrix type. Static and dynamic artificial neural networks of the same topology were developed to model dissolution profiles of different matrix tablets types (hydrophilic/lipid) using formulation composition, compression force used for tableting and tablets porosity and tensile strength as input data. Potential application of decision trees in discovering knowledge from experimental data was also investigated. Polyethylene oxide polymer and glyceryl palmitostearate were used as matrix forming materials for hydrophilic and lipid matrix tablets, respectively whereas selected model drugs were diclofenac sodium and caffeine. Matrix tablets were prepared by direct compression method and tested for in vitro dissolution profiles. Optimization of static and dynamic neural networks used for modeling of drug release was performed using Monte Carlo simulations or genetic algorithms optimizer. Decision trees were constructed following discretization of data. Calculated difference (f(1)) and similarity (f(2)) factors for predicted and experimentally obtained dissolution profiles of test matrix tablets formulations indicate that Elman dynamic neural networks as well as decision trees are capable of accurate predictions of both hydrophilic and lipid matrix tablets dissolution profiles. Elman neural networks were compared to most frequently used static network, Multi-layered perceptron, and superiority of Elman networks have been demonstrated. Developed methods allow simple, yet very precise way of drug release predictions for both hydrophilic and lipid matrix tablets having controlled drug release.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees
VL  - 428
IS  - 1-2
SP  - 57
EP  - 67
DO  - 10.1016/j.ijpharm.2012.02.031
ER  - 

@article{
author = "Petrović, Jelena and Ibrić, Svetlana and Betz, Gabriele and Đurić, Zorica",
year = "2012",
abstract = "The main objective of the study was to develop artificial intelligence methods for optimization of drug release from matrix tablets regardless of the matrix type. Static and dynamic artificial neural networks of the same topology were developed to model dissolution profiles of different matrix tablets types (hydrophilic/lipid) using formulation composition, compression force used for tableting and tablets porosity and tensile strength as input data. Potential application of decision trees in discovering knowledge from experimental data was also investigated. Polyethylene oxide polymer and glyceryl palmitostearate were used as matrix forming materials for hydrophilic and lipid matrix tablets, respectively whereas selected model drugs were diclofenac sodium and caffeine. Matrix tablets were prepared by direct compression method and tested for in vitro dissolution profiles. Optimization of static and dynamic neural networks used for modeling of drug release was performed using Monte Carlo simulations or genetic algorithms optimizer. Decision trees were constructed following discretization of data. Calculated difference (f(1)) and similarity (f(2)) factors for predicted and experimentally obtained dissolution profiles of test matrix tablets formulations indicate that Elman dynamic neural networks as well as decision trees are capable of accurate predictions of both hydrophilic and lipid matrix tablets dissolution profiles. Elman neural networks were compared to most frequently used static network, Multi-layered perceptron, and superiority of Elman networks have been demonstrated. Developed methods allow simple, yet very precise way of drug release predictions for both hydrophilic and lipid matrix tablets having controlled drug release.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees",
volume = "428",
number = "1-2",
pages = "57-67",
doi = "10.1016/j.ijpharm.2012.02.031"
}

Petrović, J., Ibrić, S., Betz, G.,& Đurić, Z.. (2012). Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 428(1-2), 57-67.
https://doi.org/10.1016/j.ijpharm.2012.02.031

Petrović J, Ibrić S, Betz G, Đurić Z. Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees. in International Journal of Pharmaceutics. 2012;428(1-2):57-67.
doi:10.1016/j.ijpharm.2012.02.031 .

Petrović, Jelena, Ibrić, Svetlana, Betz, Gabriele, Đurić, Zorica, "Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees" in International Journal of Pharmaceutics, 428, no. 1-2 (2012):57-67,
https://doi.org/10.1016/j.ijpharm.2012.02.031 . .

TY  - JOUR
AU  - Chansanroj, Krisanin
AU  - Petrović, Jelena
AU  - Ibrić, Svetlana
AU  - Betz, Gabriele
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1504
AB  - Artificial neural networks (ANNs) were applied for system understanding and prediction of drug release properties from direct compacted matrix tablets using sucrose esters (SEs) as matrix-forming agents for controlled release of a highly water soluble drug, metoprolol tartrate. Complexity of the system was presented through the effects of SE concentration and tablet porosity at various hydrophilic-lipophilic balance (HLB) values of SEs ranging from 0 to 16. Both effects contributed to release behaviors especially in the system containing hydrophilic SEs where swelling phenomena occurred. A self-organizing map neural network (SOM) was applied for visualizing interrelation among the variables and multilayer perceptron neural networks (MLPs) were employed to generalize the system and predict the drug release properties based on HLB value and concentration of SEs and tablet properties, i.e., tablet porosity, volume and tensile strength. Accurate prediction was obtained after systematically optimizing network performance based on learning algorithm of MLP. Drug release was mainly attributed to the effects of SEs, tablet volume and tensile strength in multi-dimensional interrelation whereas tablet porosity gave a small impact. Ability of system generalization and accurate prediction of the drug release properties proves the validity of SOM and MLPs for the formulation modeling of direct compacted matrix tablets containing controlled release agents of different material properties.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks
VL  - 44
IS  - 3
SP  - 321
EP  - 331
DO  - 10.1016/j.ejps.2011.08.012
ER  - 

@article{
author = "Chansanroj, Krisanin and Petrović, Jelena and Ibrić, Svetlana and Betz, Gabriele",
year = "2011",
abstract = "Artificial neural networks (ANNs) were applied for system understanding and prediction of drug release properties from direct compacted matrix tablets using sucrose esters (SEs) as matrix-forming agents for controlled release of a highly water soluble drug, metoprolol tartrate. Complexity of the system was presented through the effects of SE concentration and tablet porosity at various hydrophilic-lipophilic balance (HLB) values of SEs ranging from 0 to 16. Both effects contributed to release behaviors especially in the system containing hydrophilic SEs where swelling phenomena occurred. A self-organizing map neural network (SOM) was applied for visualizing interrelation among the variables and multilayer perceptron neural networks (MLPs) were employed to generalize the system and predict the drug release properties based on HLB value and concentration of SEs and tablet properties, i.e., tablet porosity, volume and tensile strength. Accurate prediction was obtained after systematically optimizing network performance based on learning algorithm of MLP. Drug release was mainly attributed to the effects of SEs, tablet volume and tensile strength in multi-dimensional interrelation whereas tablet porosity gave a small impact. Ability of system generalization and accurate prediction of the drug release properties proves the validity of SOM and MLPs for the formulation modeling of direct compacted matrix tablets containing controlled release agents of different material properties.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks",
volume = "44",
number = "3",
pages = "321-331",
doi = "10.1016/j.ejps.2011.08.012"
}

Chansanroj, K., Petrović, J., Ibrić, S.,& Betz, G.. (2011). Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 44(3), 321-331.
https://doi.org/10.1016/j.ejps.2011.08.012

Chansanroj K, Petrović J, Ibrić S, Betz G. Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks. in European Journal of Pharmaceutical Sciences. 2011;44(3):321-331.
doi:10.1016/j.ejps.2011.08.012 .

Chansanroj, Krisanin, Petrović, Jelena, Ibrić, Svetlana, Betz, Gabriele, "Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks" in European Journal of Pharmaceutical Sciences, 44, no. 3 (2011):321-331,
https://doi.org/10.1016/j.ejps.2011.08.012 . .

TY  - JOUR
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Petrović, Jelena
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1496
PB  - Savez hemijskih inženjera, Beograd
T2  - CICEQ - Chemical Industry and Chemical Engineering Quarterly
T1  - Artificial intelligence in pharmaceutical product formulation: neural computing (Retraction of vol 15, pg 227, 2009)
VL  - 17
IS  - 4
SP  - 543
EP  - 543
DO  - 10.2298/CICEQ1104000E
ER  - 

@article{
author = "Ibrić, Svetlana and Đurić, Zorica and Parojčić, Jelena and Petrović, Jelena",
year = "2011",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "CICEQ - Chemical Industry and Chemical Engineering Quarterly",
title = "Artificial intelligence in pharmaceutical product formulation: neural computing (Retraction of vol 15, pg 227, 2009)",
volume = "17",
number = "4",
pages = "543-543",
doi = "10.2298/CICEQ1104000E"
}

Ibrić, S., Đurić, Z., Parojčić, J.,& Petrović, J.. (2011). Artificial intelligence in pharmaceutical product formulation: neural computing (Retraction of vol 15, pg 227, 2009). in CICEQ - Chemical Industry and Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 17(4), 543-543.
https://doi.org/10.2298/CICEQ1104000E

Ibrić S, Đurić Z, Parojčić J, Petrović J. Artificial intelligence in pharmaceutical product formulation: neural computing (Retraction of vol 15, pg 227, 2009). in CICEQ - Chemical Industry and Chemical Engineering Quarterly. 2011;17(4):543-543.
doi:10.2298/CICEQ1104000E .

Ibrić, Svetlana, Đurić, Zorica, Parojčić, Jelena, Petrović, Jelena, "Artificial intelligence in pharmaceutical product formulation: neural computing (Retraction of vol 15, pg 227, 2009)" in CICEQ - Chemical Industry and Chemical Engineering Quarterly, 17, no. 4 (2011):543-543,
https://doi.org/10.2298/CICEQ1104000E . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Chansanroj, Krisanin
AU  - Meier, Brigitte
AU  - Ibrić, Svetlana
AU  - Betz, Gabriele
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1484
AB  - Various modeling techniques have been applied to analyze fluidized-bed granulation process. Influence of various input parameters (product, inlet and outlet air temperature, consumption of liquid-binder, granulation liquid-binder spray rate, spray pressure, drying time) on granulation output properties (granule flow rate, granule size determined using light scattering method and sieve analysis, granules Hausner ratio, porosity and residual moisture) has been assessed. Both conventional and novel modeling techniques were used, such as screening test, multiple regression analysis, self-organizing maps, artificial neural networks, decision trees and rule induction. Diverse testing of developed models (internal and external validation) has been discussed. Good correlation has been obtained between the predicted and the experimental data. It has been shown that nonlinear methods based on artificial intelligence, such as neural networks, are far better in generalization and prediction in comparison to conventional methods. Possibility of usage of SOMs, decision trees and rule induction technique to monitor and optimize fluidized-bed granulation process has also been demonstrated. Obtained findings can serve as guidance to implementation of modeling techniques in fluidized-bed granulation process understanding and control.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Analysis of fluidized bed granulation process using conventional and novel modeling techniques
VL  - 44
IS  - 3
SP  - 227
EP  - 234
DO  - 10.1016/j.ejps.2011.07.013
ER  - 

@article{
author = "Petrović, Jelena and Chansanroj, Krisanin and Meier, Brigitte and Ibrić, Svetlana and Betz, Gabriele",
year = "2011",
abstract = "Various modeling techniques have been applied to analyze fluidized-bed granulation process. Influence of various input parameters (product, inlet and outlet air temperature, consumption of liquid-binder, granulation liquid-binder spray rate, spray pressure, drying time) on granulation output properties (granule flow rate, granule size determined using light scattering method and sieve analysis, granules Hausner ratio, porosity and residual moisture) has been assessed. Both conventional and novel modeling techniques were used, such as screening test, multiple regression analysis, self-organizing maps, artificial neural networks, decision trees and rule induction. Diverse testing of developed models (internal and external validation) has been discussed. Good correlation has been obtained between the predicted and the experimental data. It has been shown that nonlinear methods based on artificial intelligence, such as neural networks, are far better in generalization and prediction in comparison to conventional methods. Possibility of usage of SOMs, decision trees and rule induction technique to monitor and optimize fluidized-bed granulation process has also been demonstrated. Obtained findings can serve as guidance to implementation of modeling techniques in fluidized-bed granulation process understanding and control.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Analysis of fluidized bed granulation process using conventional and novel modeling techniques",
volume = "44",
number = "3",
pages = "227-234",
doi = "10.1016/j.ejps.2011.07.013"
}

Petrović, J., Chansanroj, K., Meier, B., Ibrić, S.,& Betz, G.. (2011). Analysis of fluidized bed granulation process using conventional and novel modeling techniques. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 44(3), 227-234.
https://doi.org/10.1016/j.ejps.2011.07.013

Petrović J, Chansanroj K, Meier B, Ibrić S, Betz G. Analysis of fluidized bed granulation process using conventional and novel modeling techniques. in European Journal of Pharmaceutical Sciences. 2011;44(3):227-234.
doi:10.1016/j.ejps.2011.07.013 .

Petrović, Jelena, Chansanroj, Krisanin, Meier, Brigitte, Ibrić, Svetlana, Betz, Gabriele, "Analysis of fluidized bed granulation process using conventional and novel modeling techniques" in European Journal of Pharmaceutical Sciences, 44, no. 3 (2011):227-234,
https://doi.org/10.1016/j.ejps.2011.07.013 . .

TY  - CONF
AU  - Kostovski, D.
AU  - Petrović, Jelena
AU  - Jordanoska, S.
AU  - Arsova, M.
AU  - Ugarković, S.
AU  - Ibrić, Svetlana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1462
PB  - Elsevier Science BV, Amsterdam
C3  - European Journal of Pharmaceutical Sciences
T1  - Optimization of dissolution method for nimesuluide tablets using response surface methodology
VL  - 44
IS  - Supplement 1
SP  - 100
EP  - 101
DO  - 10.1016/j.ejps.2011.08.002
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1462
ER  - 

@conference{
author = "Kostovski, D. and Petrović, Jelena and Jordanoska, S. and Arsova, M. and Ugarković, S. and Ibrić, Svetlana",
year = "2011",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Optimization of dissolution method for nimesuluide tablets using response surface methodology",
volume = "44",
number = "Supplement 1",
pages = "100-101",
doi = "10.1016/j.ejps.2011.08.002",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1462"
}

Kostovski, D., Petrović, J., Jordanoska, S., Arsova, M., Ugarković, S.,& Ibrić, S.. (2011). Optimization of dissolution method for nimesuluide tablets using response surface methodology. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 44(Supplement 1), 100-101.
https://doi.org/10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1462

Kostovski D, Petrović J, Jordanoska S, Arsova M, Ugarković S, Ibrić S. Optimization of dissolution method for nimesuluide tablets using response surface methodology. in European Journal of Pharmaceutical Sciences. 2011;44(Supplement 1):100-101.
doi:10.1016/j.ejps.2011.08.002
https://hdl.handle.net/21.15107/rcub_farfar_1462 .

Kostovski, D., Petrović, Jelena, Jordanoska, S., Arsova, M., Ugarković, S., Ibrić, Svetlana, "Optimization of dissolution method for nimesuluide tablets using response surface methodology" in European Journal of Pharmaceutical Sciences, 44, no. Supplement 1 (2011):100-101,
https://doi.org/10.1016/j.ejps.2011.08.002 .,
https://hdl.handle.net/21.15107/rcub_farfar_1462 .

TY  - JOUR
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Petrović, Jelena
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1452
AB  - This article has been retracted at the request of the authors. The retraction has been made because the authors admitted that they took the text and drawings from the review article written by R. Rowe and E. Colbourn, Future Medicinal Chemistry 1(4) (2009) 713-726, without their permission and even did not include this article in the list of references. One of the conditions of submission of a paper for publication are that authors confirm that their work is entirely originally written, someone else’s data and/or text are appropriately cited or quoted and permission has been obtained for use of copyrighted material from other sources. Therefore, the retracted article represents a severe improperly usage of the scientific publishing system. Apologies are offered to readers of the Chem. Ind. Chem. Eng. Q. that this abuse was not detected during the submission process.
PB  - Savez hemijskih inženjera, Beograd
T2  - CICEQ - Chemical Industry and Chemical Engineering Quarterly
T1  - Retraction: Ibrić, S., Đurić, Z., Parojčić, J., & Petrović, J. (2009). Artificial intelligence in pharmaceutical product formulation: Neural computing. Chemical Industry and Chemical Engineering Quarterly / CICEQ, 15(4), 227-236.
VL  - 17
IS  - 4
SP  - 543
EP  - 543
DO  - 10.2298/CICEQ1104000E
ER  - 

@article{
author = "Ibrić, Svetlana and Đurić, Zorica and Parojčić, Jelena and Petrović, Jelena",
year = "2011",
abstract = "This article has been retracted at the request of the authors. The retraction has been made because the authors admitted that they took the text and drawings from the review article written by R. Rowe and E. Colbourn, Future Medicinal Chemistry 1(4) (2009) 713-726, without their permission and even did not include this article in the list of references. One of the conditions of submission of a paper for publication are that authors confirm that their work is entirely originally written, someone else’s data and/or text are appropriately cited or quoted and permission has been obtained for use of copyrighted material from other sources. Therefore, the retracted article represents a severe improperly usage of the scientific publishing system. Apologies are offered to readers of the Chem. Ind. Chem. Eng. Q. that this abuse was not detected during the submission process.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "CICEQ - Chemical Industry and Chemical Engineering Quarterly",
title = "Retraction: Ibrić, S., Đurić, Z., Parojčić, J., & Petrović, J. (2009). Artificial intelligence in pharmaceutical product formulation: Neural computing. Chemical Industry and Chemical Engineering Quarterly / CICEQ, 15(4), 227-236.",
volume = "17",
number = "4",
pages = "543-543",
doi = "10.2298/CICEQ1104000E"
}

Ibrić, S., Đurić, Z., Parojčić, J.,& Petrović, J.. (2011). Retraction: Ibrić, S., Đurić, Z., Parojčić, J., & Petrović, J. (2009). Artificial intelligence in pharmaceutical product formulation: Neural computing. Chemical Industry and Chemical Engineering Quarterly / CICEQ, 15(4), 227-236.. in CICEQ - Chemical Industry and Chemical Engineering Quarterly
Savez hemijskih inženjera, Beograd., 17(4), 543-543.
https://doi.org/10.2298/CICEQ1104000E

Ibrić S, Đurić Z, Parojčić J, Petrović J. Retraction: Ibrić, S., Đurić, Z., Parojčić, J., & Petrović, J. (2009). Artificial intelligence in pharmaceutical product formulation: Neural computing. Chemical Industry and Chemical Engineering Quarterly / CICEQ, 15(4), 227-236.. in CICEQ - Chemical Industry and Chemical Engineering Quarterly. 2011;17(4):543-543.
doi:10.2298/CICEQ1104000E .

Ibrić, Svetlana, Đurić, Zorica, Parojčić, Jelena, Petrović, Jelena, "Retraction: Ibrić, S., Đurić, Z., Parojčić, J., & Petrović, J. (2009). Artificial intelligence in pharmaceutical product formulation: Neural computing. Chemical Industry and Chemical Engineering Quarterly / CICEQ, 15(4), 227-236." in CICEQ - Chemical Industry and Chemical Engineering Quarterly, 17, no. 4 (2011):543-543,
https://doi.org/10.2298/CICEQ1104000E . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Ibrić, Svetlana
AU  - Jocković, Jelena
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1444
AB  - Percolation theory is a mathematical tool that enables insight into characteristics of geometrically complex systems. Geometrical transition of solid dosage forms is followed by sudden changes in certain tablet characteristics (mechanical properties, drug release rate). The aim of the presented study is implementation of percolation theory concepts in hydrophilic matrix tablets characterization, by determination of the percolaction thresholds for key mechanical properties of matrix tablets as well as for drug release profiles. Hydrophilic matrix tablets have been formulated using polyethylene oxide polymers as matrix forming substances, diclofenac sodium as the model drug substance, as well as mycrocristaline cellulose as a tablet filler. Varying the excipient weight ratio and applied compression force, 18 formulations have been prepared using direct compression method. Compressibility and compactibility of the excipients hava been investigated, followed by characterization of matrix tablets tensile strenght. Dissolution test for diclofenac sodium matrix tablets has been conducted using rotating paddles method, and obtained drug release profiles have been analyzed using mathematical model. In order to estimate percolation thresholds changes in matrix tablets tensile strength and kinetic parameters of dissolution profiles were studied in aspect to changes in matrix tablets relative density i.e. volumetric ratio of matrix forming substance and initial porosity of matrix tablets. Obtained values for percolation thresholds, i.e. critical porosities for tensile strenghts are 22,57 % and 50,63 % for PEO WSR 1105 and PEO WSR Coagulant hydrophilic matrix tablets respectively. Percolation threshold for kinetic parameters of diclofenac sodium release profiles for PEO WSR 1105 matrix tablets is 20,86%. Obtained results indicate that percolation thresholds can be identified as critical formulations that are susceptible to sudden changes in mechanical properties and/or characteristics in drug release profiles following minor changes in formulation composition or process parameters.
AB  - Perkolaciona teorija je matematička alatka koja omogućava uvid u karakteristike geometrijski složenih sistema. Geometrijska tranzicija u čvrstim farmaceutskim oblicima je povezana sa naglim promenama određenih karakteristika tableta (mehaničke karakteristike, brzina rastvaranja lekovite supstance). Cilj rada je implementacija koncepata perkolacione teorije u karakterizaciji hidrofilnih matriks tableta, određivanjem perkolacionih pragova za ključne mehaničke karakteristike matriks tableta kao i za profile brzine rastvaranja lekovite supstance. Hidrofilne matriks tablete su izrađene sa polietilen oksidnim polimerima kao matriks-formirajućim materijalima, diklofenak-natrijumom kao lekovitom supstancom i mikrokristalnom celulozom kao sredstvom za dopunjavanje. Izrađeno je 18 formulacija variranjem masenog udela ekscipijenasa i primenjene sile kompresije, pri čemu su matriks tablete izrađene metodom direktne kompresije. Ispitana je kompresibilnost i kompaktibilnost ekscipijenasa, kao i zatezna čvrstoća izrađenih matriks tableta. Brzina rastvaranja diklofenak-natrijuma iz matriks tableta je ispitana u aparaturi sa rotirajućom lopaticom, a dobijeni profili su analizirani primenom matematičkog modela. Perkolacioni pragovi su određeni praćenjem promena u zateznoj čvrstoći matriks tableta i kinetičkim parametrima profila brzine rastvaranja lekovite supstance, u funkciji relativne gustine matriks tableta odnosno zapreminskog udela matriks-formirajuće supstance i poroziteta matriks tableta. Dobijene vrednosti perkolacionih pragova, tj. kritičnih poroziteta za zateznu čvrstoću iznose 22,57% odnosno 50,63% za PEO WSR 1105 i PEO WSR Coagulant hidrofilne matriks tablete. Perkolacioni prag za kinetičke parametre profila brzine rastvaranja diklofenak-natrijuma za PEO WSR 1105 hidrofilne matriks tablete iznosi 20,86 %. Dobijeni rezultati ukazuju na mogućnost identifikacije perkolacionih pragova kao kritičnih formulacija koje podležu naglim promenama karakteristika matriks tableta sa manjim promenama u sastavu formulacija ili parametara procesa izrade.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Application of the percolation theory in the formulation of pharmaceutical dosage forms: Hydrophilic matrix tablets
T1  - Primena perkolacione teorije u formulaciji farmaceutskih oblika - hidrofilne matriks tablete
VL  - 60
IS  - 6
SP  - 1219
EP  - 1236
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1444
ER  - 

@article{
author = "Petrović, Jelena and Ibrić, Svetlana and Jocković, Jelena and Parojčić, Jelena and Đurić, Zorica",
year = "2010",
abstract = "Percolation theory is a mathematical tool that enables insight into characteristics of geometrically complex systems. Geometrical transition of solid dosage forms is followed by sudden changes in certain tablet characteristics (mechanical properties, drug release rate). The aim of the presented study is implementation of percolation theory concepts in hydrophilic matrix tablets characterization, by determination of the percolaction thresholds for key mechanical properties of matrix tablets as well as for drug release profiles. Hydrophilic matrix tablets have been formulated using polyethylene oxide polymers as matrix forming substances, diclofenac sodium as the model drug substance, as well as mycrocristaline cellulose as a tablet filler. Varying the excipient weight ratio and applied compression force, 18 formulations have been prepared using direct compression method. Compressibility and compactibility of the excipients hava been investigated, followed by characterization of matrix tablets tensile strenght. Dissolution test for diclofenac sodium matrix tablets has been conducted using rotating paddles method, and obtained drug release profiles have been analyzed using mathematical model. In order to estimate percolation thresholds changes in matrix tablets tensile strength and kinetic parameters of dissolution profiles were studied in aspect to changes in matrix tablets relative density i.e. volumetric ratio of matrix forming substance and initial porosity of matrix tablets. Obtained values for percolation thresholds, i.e. critical porosities for tensile strenghts are 22,57 % and 50,63 % for PEO WSR 1105 and PEO WSR Coagulant hydrophilic matrix tablets respectively. Percolation threshold for kinetic parameters of diclofenac sodium release profiles for PEO WSR 1105 matrix tablets is 20,86%. Obtained results indicate that percolation thresholds can be identified as critical formulations that are susceptible to sudden changes in mechanical properties and/or characteristics in drug release profiles following minor changes in formulation composition or process parameters., Perkolaciona teorija je matematička alatka koja omogućava uvid u karakteristike geometrijski složenih sistema. Geometrijska tranzicija u čvrstim farmaceutskim oblicima je povezana sa naglim promenama određenih karakteristika tableta (mehaničke karakteristike, brzina rastvaranja lekovite supstance). Cilj rada je implementacija koncepata perkolacione teorije u karakterizaciji hidrofilnih matriks tableta, određivanjem perkolacionih pragova za ključne mehaničke karakteristike matriks tableta kao i za profile brzine rastvaranja lekovite supstance. Hidrofilne matriks tablete su izrađene sa polietilen oksidnim polimerima kao matriks-formirajućim materijalima, diklofenak-natrijumom kao lekovitom supstancom i mikrokristalnom celulozom kao sredstvom za dopunjavanje. Izrađeno je 18 formulacija variranjem masenog udela ekscipijenasa i primenjene sile kompresije, pri čemu su matriks tablete izrađene metodom direktne kompresije. Ispitana je kompresibilnost i kompaktibilnost ekscipijenasa, kao i zatezna čvrstoća izrađenih matriks tableta. Brzina rastvaranja diklofenak-natrijuma iz matriks tableta je ispitana u aparaturi sa rotirajućom lopaticom, a dobijeni profili su analizirani primenom matematičkog modela. Perkolacioni pragovi su određeni praćenjem promena u zateznoj čvrstoći matriks tableta i kinetičkim parametrima profila brzine rastvaranja lekovite supstance, u funkciji relativne gustine matriks tableta odnosno zapreminskog udela matriks-formirajuće supstance i poroziteta matriks tableta. Dobijene vrednosti perkolacionih pragova, tj. kritičnih poroziteta za zateznu čvrstoću iznose 22,57% odnosno 50,63% za PEO WSR 1105 i PEO WSR Coagulant hidrofilne matriks tablete. Perkolacioni prag za kinetičke parametre profila brzine rastvaranja diklofenak-natrijuma za PEO WSR 1105 hidrofilne matriks tablete iznosi 20,86 %. Dobijeni rezultati ukazuju na mogućnost identifikacije perkolacionih pragova kao kritičnih formulacija koje podležu naglim promenama karakteristika matriks tableta sa manjim promenama u sastavu formulacija ili parametara procesa izrade.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of the percolation theory in the formulation of pharmaceutical dosage forms: Hydrophilic matrix tablets, Primena perkolacione teorije u formulaciji farmaceutskih oblika - hidrofilne matriks tablete",
volume = "60",
number = "6",
pages = "1219-1236",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1444"
}

Petrović, J., Ibrić, S., Jocković, J., Parojčić, J.,& Đurić, Z.. (2010). Application of the percolation theory in the formulation of pharmaceutical dosage forms: Hydrophilic matrix tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 60(6), 1219-1236.
https://hdl.handle.net/21.15107/rcub_farfar_1444

Petrović J, Ibrić S, Jocković J, Parojčić J, Đurić Z. Application of the percolation theory in the formulation of pharmaceutical dosage forms: Hydrophilic matrix tablets. in Arhiv za farmaciju. 2010;60(6):1219-1236.
https://hdl.handle.net/21.15107/rcub_farfar_1444 .

Petrović, Jelena, Ibrić, Svetlana, Jocković, Jelena, Parojčić, Jelena, Đurić, Zorica, "Application of the percolation theory in the formulation of pharmaceutical dosage forms: Hydrophilic matrix tablets" in Arhiv za farmaciju, 60, no. 6 (2010):1219-1236,
https://hdl.handle.net/21.15107/rcub_farfar_1444 .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Ibrić, Svetlana
AU  - Betz, Gabriele
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1263
AB  - The main objective of this study was to demonstrate the possible use of dynamic neural networks to model diclofenac sodium release from polyethylene oxide hydrophilic matrix tablets. High and low molecular weight polymers in the range of 0.9-5 x 10(6) have been used as matrix forming materials and 12 different formulations were prepared for each polymer. Matrix tablets were made by direct compression method. Fractions of polymer and compression force have been selected as most influential factors on diclofenac sodium release profile. In vitro dissolution profile has been treated as time series using dynamic neural networks. Dynamic networks are expected to be advantageous in the modeling of drug release. Networks of different topologies have been constructed in order to obtain precise prediction of release profiles for test formulations. Short-term and long-term memory structures have been included in the design of network making it possible to treat dissolution profiles as time series. The ability of network to model drug release has been assessed by the determination of correlation between predicted and experimentally obtained data. Calculated difference (f(1)) and similarity (f(2)) factors indicate that dynamic networks are capable of accurate predictions. Dynamic neural networks were compared to most frequently used static network, multi-layered perceptron, and superiority of dynamic networks has been demonstrated. The study also demonstrated differences between the used polyethylene oxide polymers in respect to drug release and suggests explanations for the obtained results.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets
VL  - 38
IS  - 2
SP  - 172
EP  - 180
DO  - 10.1016/j.ejps.2009.07.007
ER  - 

@article{
author = "Petrović, Jelena and Ibrić, Svetlana and Betz, Gabriele and Parojčić, Jelena and Đurić, Zorica",
year = "2009",
abstract = "The main objective of this study was to demonstrate the possible use of dynamic neural networks to model diclofenac sodium release from polyethylene oxide hydrophilic matrix tablets. High and low molecular weight polymers in the range of 0.9-5 x 10(6) have been used as matrix forming materials and 12 different formulations were prepared for each polymer. Matrix tablets were made by direct compression method. Fractions of polymer and compression force have been selected as most influential factors on diclofenac sodium release profile. In vitro dissolution profile has been treated as time series using dynamic neural networks. Dynamic networks are expected to be advantageous in the modeling of drug release. Networks of different topologies have been constructed in order to obtain precise prediction of release profiles for test formulations. Short-term and long-term memory structures have been included in the design of network making it possible to treat dissolution profiles as time series. The ability of network to model drug release has been assessed by the determination of correlation between predicted and experimentally obtained data. Calculated difference (f(1)) and similarity (f(2)) factors indicate that dynamic networks are capable of accurate predictions. Dynamic neural networks were compared to most frequently used static network, multi-layered perceptron, and superiority of dynamic networks has been demonstrated. The study also demonstrated differences between the used polyethylene oxide polymers in respect to drug release and suggests explanations for the obtained results.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets",
volume = "38",
number = "2",
pages = "172-180",
doi = "10.1016/j.ejps.2009.07.007"
}

Petrović, J., Ibrić, S., Betz, G., Parojčić, J.,& Đurić, Z.. (2009). Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 38(2), 172-180.
https://doi.org/10.1016/j.ejps.2009.07.007

Petrović J, Ibrić S, Betz G, Parojčić J, Đurić Z. Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets. in European Journal of Pharmaceutical Sciences. 2009;38(2):172-180.
doi:10.1016/j.ejps.2009.07.007 .

Petrović, Jelena, Ibrić, Svetlana, Betz, Gabriele, Parojčić, Jelena, Đurić, Zorica, "Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets" in European Journal of Pharmaceutical Sciences, 38, no. 2 (2009):172-180,
https://doi.org/10.1016/j.ejps.2009.07.007 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Jocković, Jelena
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1193
AB  - Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.
PB  - Wiley-Blackwell Publishing, Inc, Malden
T2  - Journal of Pharmacy and Pharmacology
T1  - Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices
VL  - 61
IS  - 11
SP  - 1449
EP  - 1456
DO  - 10.1211/jpp/61.11.0003
ER  - 

@article{
author = "Petrović, Jelena and Jocković, Jelena and Ibrić, Svetlana and Đurić, Zorica",
year = "2009",
abstract = "Objectives The main objective of this study was to develop a mathematical model for the characterization of diclofenac sodium diffusion from polyethylene oxide (PEO) matrices. A model was developed on the basis of the diffusion theory accounting for the characteristics of the polymer: swelling with subsequent dissolution in water. The concentration-dependent diffusion of drug and water was taken into account. Experimental data were analysed using a computer software program as an aid for solving partial differential equations. Methods Six formulations of matrix tablets with different drug-excipient ratios were prepared using low-molecular-weight PEO as a matrix-forming material. For obtaining drug release data, dissolution studies were performed and water uptake by pure PEO matrices was studied as well. Key findings A good agreement of the developed model with experimental results was demonstrated. Some anomalies in drug diffusion were observed and their origin was questioned. Changes in the parameters characterizing the process of diffusion are attributed to glassy-rubbery polymer transitions. Additional interpretation of this phenomenon on the basis of percolation theory is also provided. Conclusions The obtained model has the ability to predict the required characteristics of matrices for desired drug release. The composition of batches with undesirable release properties can be predetermined and avoided in manufacturing.",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "Journal of Pharmacy and Pharmacology",
title = "Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices",
volume = "61",
number = "11",
pages = "1449-1456",
doi = "10.1211/jpp/61.11.0003"
}

Petrović, J., Jocković, J., Ibrić, S.,& Đurić, Z.. (2009). Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. in Journal of Pharmacy and Pharmacology
Wiley-Blackwell Publishing, Inc, Malden., 61(11), 1449-1456.
https://doi.org/10.1211/jpp/61.11.0003

Petrović J, Jocković J, Ibrić S, Đurić Z. Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices. in Journal of Pharmacy and Pharmacology. 2009;61(11):1449-1456.
doi:10.1211/jpp/61.11.0003 .

Petrović, Jelena, Jocković, Jelena, Ibrić, Svetlana, Đurić, Zorica, "Modelling of diclofenac sodium diffusion from swellable and water-soluble polyethylene oxide matrices" in Journal of Pharmacy and Pharmacology, 61, no. 11 (2009):1449-1456,
https://doi.org/10.1211/jpp/61.11.0003 . .