@article{
author = "Miljković, Milica and Stefanović, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Dumić, Jerka and Cerne, Darko and Jelić-Ivanović, Zorana and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients",
volume = "56",
number = "4",
pages = "673-680",
doi = "10.20471/acc.2017.56.04.14"
}