TY  - CONF
AU  - Elezović, Amar
AU  - Cvijić, Sandra
AU  - Elezović, Alisa
AU  - Pilipović, Saša
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3933
AB  - In last two decades in silico biopharmaceutics modelling has become increasingly important in all stages of drug development. One of the widely used pharmacokinetic modelling software is Gastro Plus that, with its additional dosage routes modules, enables creation of pharmacokinetic models, amongst others, for pulmonary dosage route. Medicines that are applied via that route have specific methods for characterization and analysis. However, drug that is target of in silico method in Gastro Plus is not characterized in full extent with such parameters. In this work we created various models of size distributions and depositions of two pMDI preparations containing beclomethasone dipropionate in 4 respiratory compartments of Gastro Plus Pulmonary model. Those data were compared with results of in vivo studies and model with best correlation was obtained. Such model with defined cut-off limits between each compartment enables better prediction of pharmacokinetic properties in generated Gastro Plus in silico model.
PB  - Springer, Cham
C3  - Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021
T1  - Particle Deposition in Respiratory Tract: Where are the Limits?
VL  - 84
SP  - 638
EP  - 644
DO  - 10.1007/978-3-030-73909-6_74
ER  - 

@conference{
author = "Elezović, Amar and Cvijić, Sandra and Elezović, Alisa and Pilipović, Saša and Parojčić, Jelena",
year = "2021",
abstract = "In last two decades in silico biopharmaceutics modelling has become increasingly important in all stages of drug development. One of the widely used pharmacokinetic modelling software is Gastro Plus that, with its additional dosage routes modules, enables creation of pharmacokinetic models, amongst others, for pulmonary dosage route. Medicines that are applied via that route have specific methods for characterization and analysis. However, drug that is target of in silico method in Gastro Plus is not characterized in full extent with such parameters. In this work we created various models of size distributions and depositions of two pMDI preparations containing beclomethasone dipropionate in 4 respiratory compartments of Gastro Plus Pulmonary model. Those data were compared with results of in vivo studies and model with best correlation was obtained. Such model with defined cut-off limits between each compartment enables better prediction of pharmacokinetic properties in generated Gastro Plus in silico model.",
publisher = "Springer, Cham",
journal = "Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021",
title = "Particle Deposition in Respiratory Tract: Where are the Limits?",
volume = "84",
pages = "638-644",
doi = "10.1007/978-3-030-73909-6_74"
}

Elezović, A., Cvijić, S., Elezović, A., Pilipović, S.,& Parojčić, J.. (2021). Particle Deposition in Respiratory Tract: Where are the Limits?. in Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021
Springer, Cham., 84, 638-644.
https://doi.org/10.1007/978-3-030-73909-6_74

Elezović A, Cvijić S, Elezović A, Pilipović S, Parojčić J. Particle Deposition in Respiratory Tract: Where are the Limits?. in Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021. 2021;84:638-644.
doi:10.1007/978-3-030-73909-6_74 .

Elezović, Amar, Cvijić, Sandra, Elezović, Alisa, Pilipović, Saša, Parojčić, Jelena, "Particle Deposition in Respiratory Tract: Where are the Limits?" in Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021, 84 (2021):638-644,
https://doi.org/10.1007/978-3-030-73909-6_74 . .