TY  - JOUR
AU  - Cebović, Tatjana
AU  - Arsenijević, Jelena
AU  - Drobac, Milica
AU  - Živković, Jelena
AU  - Šoštarić, Ivan
AU  - Maksimović, Zoran
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3158
AB  - Deodorised water extracts of aromatic plants are obtained as by-products of essential oil isolation and usually discarded as waste. However, phytochemical composition of these extracts encourages their further utilization as food additives or functional food ingredients. In this study we investigated phytochemical composition, antioxidant and in vivo antiproliferative activity of deodorised water extract of Thymus pannonicus All. (DWE). HPLC analysis revealed rosmarinic acid (RA) (71.11 +/- 1.54 mg/g) as the most abundant constituent of the extract, followed by salvianolic acid H (14.83 +/- 0.79 mg/g, calculated as RA). DWE exhibited pronounced antioxidant activity in vitro, in FRAP and DPPH tests (FRAP value: 7.41 mmol Fe/g and SC50: 3.80 mu g/g, respectively). Using the model of Ehrlich carcinoma cells in mice that were treated with DWE prior, at the time, and after tumour cells implantation, the tumour growth suppression and redox status of malignant cells (i.e., activities of antioxidant enzymes, level of glutathione and intensity of lipid peroxidation) were followed. DWE applied as pretreatment caused disturbance of antioxidant equilibrium as well as apoptosis/necrosis of up to 90% EAC cells. Results obtained in the present study revealed chemopreventive potential and possibility of T. pannonicus DWE usage. High content of RA and other phenolic compounds explains, at least in part, the observed effects.
PB  - Springer India, New Delhi
T2  - Journal of Food Science and Technology-Mysore
T1  - Potential use of deodorised water extracts: polyphenol-rich extract of Thymus pannonicus All. as a chemopreventive agent
VL  - 55
IS  - 2
SP  - 560
EP  - 567
DO  - 10.1007/s13197-017-2965-1
ER  - 

@article{
author = "Cebović, Tatjana and Arsenijević, Jelena and Drobac, Milica and Živković, Jelena and Šoštarić, Ivan and Maksimović, Zoran",
year = "2018",
abstract = "Deodorised water extracts of aromatic plants are obtained as by-products of essential oil isolation and usually discarded as waste. However, phytochemical composition of these extracts encourages their further utilization as food additives or functional food ingredients. In this study we investigated phytochemical composition, antioxidant and in vivo antiproliferative activity of deodorised water extract of Thymus pannonicus All. (DWE). HPLC analysis revealed rosmarinic acid (RA) (71.11 +/- 1.54 mg/g) as the most abundant constituent of the extract, followed by salvianolic acid H (14.83 +/- 0.79 mg/g, calculated as RA). DWE exhibited pronounced antioxidant activity in vitro, in FRAP and DPPH tests (FRAP value: 7.41 mmol Fe/g and SC50: 3.80 mu g/g, respectively). Using the model of Ehrlich carcinoma cells in mice that were treated with DWE prior, at the time, and after tumour cells implantation, the tumour growth suppression and redox status of malignant cells (i.e., activities of antioxidant enzymes, level of glutathione and intensity of lipid peroxidation) were followed. DWE applied as pretreatment caused disturbance of antioxidant equilibrium as well as apoptosis/necrosis of up to 90% EAC cells. Results obtained in the present study revealed chemopreventive potential and possibility of T. pannonicus DWE usage. High content of RA and other phenolic compounds explains, at least in part, the observed effects.",
publisher = "Springer India, New Delhi",
journal = "Journal of Food Science and Technology-Mysore",
title = "Potential use of deodorised water extracts: polyphenol-rich extract of Thymus pannonicus All. as a chemopreventive agent",
volume = "55",
number = "2",
pages = "560-567",
doi = "10.1007/s13197-017-2965-1"
}

Cebović, T., Arsenijević, J., Drobac, M., Živković, J., Šoštarić, I.,& Maksimović, Z.. (2018). Potential use of deodorised water extracts: polyphenol-rich extract of Thymus pannonicus All. as a chemopreventive agent. in Journal of Food Science and Technology-Mysore
Springer India, New Delhi., 55(2), 560-567.
https://doi.org/10.1007/s13197-017-2965-1

Cebović T, Arsenijević J, Drobac M, Živković J, Šoštarić I, Maksimović Z. Potential use of deodorised water extracts: polyphenol-rich extract of Thymus pannonicus All. as a chemopreventive agent. in Journal of Food Science and Technology-Mysore. 2018;55(2):560-567.
doi:10.1007/s13197-017-2965-1 .

Cebović, Tatjana, Arsenijević, Jelena, Drobac, Milica, Živković, Jelena, Šoštarić, Ivan, Maksimović, Zoran, "Potential use of deodorised water extracts: polyphenol-rich extract of Thymus pannonicus All. as a chemopreventive agent" in Journal of Food Science and Technology-Mysore, 55, no. 2 (2018):560-567,
https://doi.org/10.1007/s13197-017-2965-1 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Barreira, Joao C. M.
AU  - Stojković, Dejan
AU  - Cebović, Tatjana
AU  - Santos-Buelga, Celestino
AU  - Maksimović, Zoran
AU  - Ferreira, Isabel C. F. R.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2211
AB  - The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Functional Foods
T1  - Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.
VL  - 9
SP  - 192
EP  - 201
DO  - 10.1016/j.jff.2014.04.024
ER  - 

@article{
author = "Živković, Jelena and Barreira, Joao C. M. and Stojković, Dejan and Cebović, Tatjana and Santos-Buelga, Celestino and Maksimović, Zoran and Ferreira, Isabel C. F. R.",
year = "2014",
abstract = "The phenolic profile and antibacterial, antimutagenic and antitumour activities of the methanolic extracts of Veronica urticifolia Jacq. were evaluated. HPLC-DAD/ESI-MS analysis revealed the presence of phenolic acids, flavonoids and phenylethanoids, with acteoside as the main component (14.9 mg/g of extract). Antibacterial effect was determined using the microbroth dilution assay and Staphylococcus aureus was the most sensitive strain (MIC and MBC = 7.5 mg/mL). Antimutagenic activity was evaluated by Ames mutagenicity assay. At 1 mg/plate, the tested extract afforded high protection against the mutagenicity of nitroquinoline-N-oxide (4NQO) to Salmonella typhimurium strain TA100 (inhibition rate 48.3%). Antitumour activity was screened in Ehrlich ascites carcinoma (EAC) model. Pretreatment with 2 mg/kg body weight showed statistically significant decrease in tumour cell viability, while ascites volume and tumour cell count became slightly decreased, but not to a statistically significant extent. The results indicate that V. urticifolia deserves further research into its potential chemoprevention effects.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Functional Foods",
title = "Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.",
volume = "9",
pages = "192-201",
doi = "10.1016/j.jff.2014.04.024"
}

Živković, J., Barreira, J. C. M., Stojković, D., Cebović, T., Santos-Buelga, C., Maksimović, Z.,& Ferreira, I. C. F. R.. (2014). Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.. in Journal of Functional Foods
Elsevier Science BV, Amsterdam., 9, 192-201.
https://doi.org/10.1016/j.jff.2014.04.024

Živković J, Barreira JCM, Stojković D, Cebović T, Santos-Buelga C, Maksimović Z, Ferreira ICFR. Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq.. in Journal of Functional Foods. 2014;9:192-201.
doi:10.1016/j.jff.2014.04.024 .

Živković, Jelena, Barreira, Joao C. M., Stojković, Dejan, Cebović, Tatjana, Santos-Buelga, Celestino, Maksimović, Zoran, Ferreira, Isabel C. F. R., "Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq." in Journal of Functional Foods, 9 (2014):192-201,
https://doi.org/10.1016/j.jff.2014.04.024 . .

TY  - JOUR
AU  - Cebović, Tatjana
AU  - Maksimović, Zoran
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1746
AB  - The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Phytotherapy Research
T1  - Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats
VL  - 26
IS  - 7
SP  - 1088
EP  - 1091
DO  - 10.1002/ptr.3703
ER  - 

@article{
author = "Cebović, Tatjana and Maksimović, Zoran",
year = "2012",
abstract = "The influence of methanol extract produced from the flowers of Filipendula hexapetala Gilib. (Rosaceae) on some liver biochemical parameters in rats intoxicated with carbon tetrachloride (CTC) was evaluated in this study. The results Obtained revealed that pretreatment with the extract investigated inhibited CTC-induced liver injury by decreasing lipid peroxidation and increasing the content of reduced glutathione in a dosage dependent manner, bringing the levels of all antioxidant enzymes close to control values. The administration of CTC diminished hepatic antioxidant defense mechanisms by significant reduction of peroxidase and catalase activities. The catalase activity was significantly recovered in groups treated with the extract investigated and intoxicated with a single CTC dose. A similar impact on hepatic peroxidase activity has also been observed, indicating a partial detoxication of hydrogen peroxide by both catalase and peroxidase. Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytotherapy Research",
title = "Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats",
volume = "26",
number = "7",
pages = "1088-1091",
doi = "10.1002/ptr.3703"
}

Cebović, T.,& Maksimović, Z.. (2012). Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. in Phytotherapy Research
Wiley-Blackwell, Hoboken., 26(7), 1088-1091.
https://doi.org/10.1002/ptr.3703

Cebović T, Maksimović Z. Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats. in Phytotherapy Research. 2012;26(7):1088-1091.
doi:10.1002/ptr.3703 .

Cebović, Tatjana, Maksimović, Zoran, "Hepatoprotective Effect of Filipendula hexapetala Gilib. (Rosaceae) in Carbon Tetrachloride-induced Hepatotoxicity in Rats" in Phytotherapy Research, 26, no. 7 (2012):1088-1091,
https://doi.org/10.1002/ptr.3703 . .

TY  - JOUR
AU  - Živković, Jelena
AU  - Cebović, Tatjana
AU  - Maksimović, Zoran
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1707
AB  - The aim of the present study was to examine the antioxidant activity of three Veronica species (Plantaginaceae). The antioxidant potential of various extracts obtained from aerial flowering parts was evaluated by DPPH-free (1,1-diphenyl-2-picrylhydrazyl-free) radical scavenging activity and ferric-reducing antioxidant power assays. Considerable antioxidant activity was observed in the plant samples (FRAP values ranged from 0.97 to 4.85 mmol Fe2+/g, and DPPH IC50 values from 12.58 to 66.34 A mu g/ml); however, these levels were lower than the activity of the control compound butylated hydroxytoluene (BHT) (FRAP: 10.58 mmol Fe2+/g; DPPH IC50: 9.57 A mu g/ml). Also, the in vivo antioxidant effects were evaluated in several hepatic antioxidant systems in rats (activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase, glutathione content and level of thiobarbituric acid reactive substances) after treatment with different Veronica extracts, or in combination with carbon tetrachloride (CCl4). Pretreatment with 100 mg/kg b.w. of Veronica extracts inhibited CCl4-induced liver injury by decreasing TBA-RS level, increasing GSH content, and bringing the activities of CAT and Px to control levels. The present study suggests that the extracts analyzed could protect the liver cells from CCl4-induced liver damage by their antioxidative effect on hepatocytes.
PB  - Versita, Warsaw
T2  - Central European Journal of Biology
T1  - In vivo and in vitro antioxidant effects of three Veronica species
VL  - 7
IS  - 3
SP  - 559
EP  - 568
DO  - 10.2478/s11535-012-0041-4
ER  - 

@article{
author = "Živković, Jelena and Cebović, Tatjana and Maksimović, Zoran",
year = "2012",
abstract = "The aim of the present study was to examine the antioxidant activity of three Veronica species (Plantaginaceae). The antioxidant potential of various extracts obtained from aerial flowering parts was evaluated by DPPH-free (1,1-diphenyl-2-picrylhydrazyl-free) radical scavenging activity and ferric-reducing antioxidant power assays. Considerable antioxidant activity was observed in the plant samples (FRAP values ranged from 0.97 to 4.85 mmol Fe2+/g, and DPPH IC50 values from 12.58 to 66.34 A mu g/ml); however, these levels were lower than the activity of the control compound butylated hydroxytoluene (BHT) (FRAP: 10.58 mmol Fe2+/g; DPPH IC50: 9.57 A mu g/ml). Also, the in vivo antioxidant effects were evaluated in several hepatic antioxidant systems in rats (activities of glutathione peroxidase, glutathione reductase, peroxidase, catalase, xanthine oxidase, glutathione content and level of thiobarbituric acid reactive substances) after treatment with different Veronica extracts, or in combination with carbon tetrachloride (CCl4). Pretreatment with 100 mg/kg b.w. of Veronica extracts inhibited CCl4-induced liver injury by decreasing TBA-RS level, increasing GSH content, and bringing the activities of CAT and Px to control levels. The present study suggests that the extracts analyzed could protect the liver cells from CCl4-induced liver damage by their antioxidative effect on hepatocytes.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Biology",
title = "In vivo and in vitro antioxidant effects of three Veronica species",
volume = "7",
number = "3",
pages = "559-568",
doi = "10.2478/s11535-012-0041-4"
}

Živković, J., Cebović, T.,& Maksimović, Z.. (2012). In vivo and in vitro antioxidant effects of three Veronica species. in Central European Journal of Biology
Versita, Warsaw., 7(3), 559-568.
https://doi.org/10.2478/s11535-012-0041-4

Živković J, Cebović T, Maksimović Z. In vivo and in vitro antioxidant effects of three Veronica species. in Central European Journal of Biology. 2012;7(3):559-568.
doi:10.2478/s11535-012-0041-4 .

Živković, Jelena, Cebović, Tatjana, Maksimović, Zoran, "In vivo and in vitro antioxidant effects of three Veronica species" in Central European Journal of Biology, 7, no. 3 (2012):559-568,
https://doi.org/10.2478/s11535-012-0041-4 . .

TY  - JOUR
AU  - Maksimović, Zoran
AU  - Kovačević, Nada
AU  - Lakušić, Branislava
AU  - Cebović, Tatjana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1535
AB  - The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright
PB  - Wiley, Hoboken
T2  - Phytotherapy Research
T1  - Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract
VL  - 25
IS  - 1
SP  - 101
EP  - 105
DO  - 10.1002/ptr.3234
ER  - 

@article{
author = "Maksimović, Zoran and Kovačević, Nada and Lakušić, Branislava and Cebović, Tatjana",
year = "2011",
abstract = "The methanol extract of ripe Rumex crispus L. fruits was evaluated for its antioxidant potential by assays for ferric-reducing antioxidant power (FRAP), DPPH-free radical scavenging activity (DPPH) and the influence on lipid peroxidation in liposomes (LP). Considerable activity was observed in all test systems (FRAP: 9.9 mmol Fe2+/g; DPPH IC50: 3.7 mu g/mL; LP IC50: 4.9 mu g/mL), comparable to that of BHT (FRAP: 8.0 mu g/mL; DPPH IC50: 19.4 mu g/mL; LP IC50: 3.5 mu g/mL), but lower than the activity of ascorbic acid, rutin and quercetin, used as positive control substances. The in vivo effects were evaluated in several hepatic antioxidant systems (activities of LPx, GSH-Px, Px, CAT and XOD, as well as GSH content), after treatment with the studied yellow dock extract in different doses, or in combination with carbon tetrachloride (CCl4). Pretreatment with the R. crispus extract inhibited CCl4-induced oxidative stress by decreasing LPx and increasing GSH content in a dose dependent manner, bringing the levels of antioxidant enzymes to near control values. Copyright",
publisher = "Wiley, Hoboken",
journal = "Phytotherapy Research",
title = "Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract",
volume = "25",
number = "1",
pages = "101-105",
doi = "10.1002/ptr.3234"
}

Maksimović, Z., Kovačević, N., Lakušić, B.,& Cebović, T.. (2011). Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract. in Phytotherapy Research
Wiley, Hoboken., 25(1), 101-105.
https://doi.org/10.1002/ptr.3234

Maksimović Z, Kovačević N, Lakušić B, Cebović T. Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract. in Phytotherapy Research. 2011;25(1):101-105.
doi:10.1002/ptr.3234 .

Maksimović, Zoran, Kovačević, Nada, Lakušić, Branislava, Cebović, Tatjana, "Antioxidant Activity of Yellow Dock (Rumex crispus L., Polygonaceae) Fruit Extract" in Phytotherapy Research, 25, no. 1 (2011):101-105,
https://doi.org/10.1002/ptr.3234 . .

TY  - CONF
AU  - Cebović, Tatjana
AU  - Popović, M.
AU  - Spasić, S.
AU  - Leposavić, Gordana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/692
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effects of CO2 Viscum album L. leaves extract on in vivo oxidative stress of Ehrlich tumour cells
VL  - 164
IS  - Supplement
SP  - S111
EP  - S111
DO  - 10.1016/j.toxlet.2006.06.234
ER  - 

@conference{
author = "Cebović, Tatjana and Popović, M. and Spasić, S. and Leposavić, Gordana",
year = "2006",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effects of CO2 Viscum album L. leaves extract on in vivo oxidative stress of Ehrlich tumour cells",
volume = "164",
number = "Supplement",
pages = "S111-S111",
doi = "10.1016/j.toxlet.2006.06.234"
}

Cebović, T., Popović, M., Spasić, S.,& Leposavić, G.. (2006). Effects of CO2 Viscum album L. leaves extract on in vivo oxidative stress of Ehrlich tumour cells. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 164(Supplement), S111-S111.
https://doi.org/10.1016/j.toxlet.2006.06.234

Cebović T, Popović M, Spasić S, Leposavić G. Effects of CO2 Viscum album L. leaves extract on in vivo oxidative stress of Ehrlich tumour cells. in Toxicology Letters. 2006;164(Supplement):S111-S111.
doi:10.1016/j.toxlet.2006.06.234 .

Cebović, Tatjana, Popović, M., Spasić, S., Leposavić, Gordana, "Effects of CO2 Viscum album L. leaves extract on in vivo oxidative stress of Ehrlich tumour cells" in Toxicology Letters, 164, no. Supplement (2006):S111-S111,
https://doi.org/10.1016/j.toxlet.2006.06.234 . .

TY  - JOUR
AU  - Cebović, Tatjana
AU  - Spasić, Slavica
AU  - Popović, Mira
AU  - Borota, Jela
AU  - Leposavić, Gordana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/860
AB  - Extracts from the European mistletoe or Viscum album L. have been known as secondary medicaments, widely used in treatment of a number of disorders. Also, they have been reported to exert certain pharmacological (e.g. cytotoxic and immunomodulatory) effects in vitro and in vivo. The in vivo effect of aqueous extracts of European mistletoe (Viscum album L.) grown on plums on biochemical parameters in rats, prior and after carbon-tetrachloride-induced hepatotoxicity was examined in this study. Three sets of experiments were conducted, applying three different concentrations of aqueous Viscum album, from plum extract. Administration of CCl4 impaired defence antioxidant mechanism, particularly by depletion of liver glutathione (GSH) content and reduction of activities of catalase (CAT) and peroxidase (Px). Induction of CCl4 also caused high increase of lipid peroxidation (LP) and decrease of glutathione reductase (GR) levels. Pretreatment with examined Viscum album extract inhibited CCl4-induced liver injury by decreasing LP and increasing GSH content. bringing the levels of antioxidant enzymes to control values. CCl4-induced increases in serum alanine transaminase (ALT), aspartate transaminase (AST) and bilirubin were dramatically supressed by the aqeous mistletoe grown on plums extract treatment. Hepatic DNA content haven't been changed much upon treatment with Viscum extract, but certain decrease in DNA content was observed in CCl4 treated group. What is also important, CCl4 caused a significant increase in hepatic hydroxyproline content, compared to the control group. However, the mistletoe extract treatment attenuated this increase, indicating that examined mistletoe extracts could exhibit certain hepato-protective effect. Values of investigated parameters showed significant dosage dependence, although positive results were obtained for all examined concentrations of Viscum album L. from plum extract.
PB  - Parlar Scientific Publications (P S P), Freising
T2  - Fresenius Environmental Bulletin
T1  - The European mistletoe (Viscum album L.) grown on plums extract inhibits CCL4-induced liver damage in rats
VL  - 15
IS  - 5
SP  - 393
EP  - 400
UR  - https://hdl.handle.net/21.15107/rcub_farfar_860
ER  - 

@article{
author = "Cebović, Tatjana and Spasić, Slavica and Popović, Mira and Borota, Jela and Leposavić, Gordana",
year = "2006",
abstract = "Extracts from the European mistletoe or Viscum album L. have been known as secondary medicaments, widely used in treatment of a number of disorders. Also, they have been reported to exert certain pharmacological (e.g. cytotoxic and immunomodulatory) effects in vitro and in vivo. The in vivo effect of aqueous extracts of European mistletoe (Viscum album L.) grown on plums on biochemical parameters in rats, prior and after carbon-tetrachloride-induced hepatotoxicity was examined in this study. Three sets of experiments were conducted, applying three different concentrations of aqueous Viscum album, from plum extract. Administration of CCl4 impaired defence antioxidant mechanism, particularly by depletion of liver glutathione (GSH) content and reduction of activities of catalase (CAT) and peroxidase (Px). Induction of CCl4 also caused high increase of lipid peroxidation (LP) and decrease of glutathione reductase (GR) levels. Pretreatment with examined Viscum album extract inhibited CCl4-induced liver injury by decreasing LP and increasing GSH content. bringing the levels of antioxidant enzymes to control values. CCl4-induced increases in serum alanine transaminase (ALT), aspartate transaminase (AST) and bilirubin were dramatically supressed by the aqeous mistletoe grown on plums extract treatment. Hepatic DNA content haven't been changed much upon treatment with Viscum extract, but certain decrease in DNA content was observed in CCl4 treated group. What is also important, CCl4 caused a significant increase in hepatic hydroxyproline content, compared to the control group. However, the mistletoe extract treatment attenuated this increase, indicating that examined mistletoe extracts could exhibit certain hepato-protective effect. Values of investigated parameters showed significant dosage dependence, although positive results were obtained for all examined concentrations of Viscum album L. from plum extract.",
publisher = "Parlar Scientific Publications (P S P), Freising",
journal = "Fresenius Environmental Bulletin",
title = "The European mistletoe (Viscum album L.) grown on plums extract inhibits CCL4-induced liver damage in rats",
volume = "15",
number = "5",
pages = "393-400",
url = "https://hdl.handle.net/21.15107/rcub_farfar_860"
}

Cebović, T., Spasić, S., Popović, M., Borota, J.,& Leposavić, G.. (2006). The European mistletoe (Viscum album L.) grown on plums extract inhibits CCL4-induced liver damage in rats. in Fresenius Environmental Bulletin
Parlar Scientific Publications (P S P), Freising., 15(5), 393-400.
https://hdl.handle.net/21.15107/rcub_farfar_860

Cebović T, Spasić S, Popović M, Borota J, Leposavić G. The European mistletoe (Viscum album L.) grown on plums extract inhibits CCL4-induced liver damage in rats. in Fresenius Environmental Bulletin. 2006;15(5):393-400.
https://hdl.handle.net/21.15107/rcub_farfar_860 .

Cebović, Tatjana, Spasić, Slavica, Popović, Mira, Borota, Jela, Leposavić, Gordana, "The European mistletoe (Viscum album L.) grown on plums extract inhibits CCL4-induced liver damage in rats" in Fresenius Environmental Bulletin, 15, no. 5 (2006):393-400,
https://hdl.handle.net/21.15107/rcub_farfar_860 .